Podcasts about serious problem

Guest: Robert Christian   Guys, if this message is meaningful to you and you'd like to email Robert Christian directly, you can reach him at robjonchris@gmail.com Words of wisdom and encouragement from Robert: You are qualified God is a good father God wants the best for you God will discipline you You are created to glorify Him You do that through obedience   Resources for more encouragement: Man Alive by Patrick Morely Kingdom Man by Tony Evans The Resolution for Men by The Kendrick Brothers Abba's Child by Brennan Manning Happiness is a Serious Problem by Dennis Prager Knowing God by J.I. Packer Disciplines of a Godly Man by R. Kent Hughes   T4M guys - just a reminder that Training4Manhood is a non-profit, 501(c)(3) ministry and you can make donations either via Zelle (info@training4manhood.com) or by visiting the Training4Manhood website. Huge thank you to Jared Wood for allowing T4M to use his music in our intro and outro selections.

In today's episode of the Packernet Podcast, Ryan dives deep into the Packers' frustrating loss to the Chicago Bears, breaking down the team's persistent struggles with their passing game. From fluky turnovers and questionable play-calling to Jordan Love's back-to-back rough performances, Ryan dissects what went wrong and why the Packers need to fix their aerial attack before facing the Eagles in the playoffs. Can the Packers find a solution to reignite their passing game, or are they doomed for an early playoff exit? Tune in for a brutally honest analysis and more!  

In today's episode of the Packernet Podcast, Ryan dives deep into the Packers' frustrating loss to the Chicago Bears, breaking down the team's persistent struggles with their passing game. From fluky turnovers and questionable play-calling to Jordan Love's back-to-back rough performances, Ryan dissects what went wrong and why the Packers need to fix their aerial attack before facing the Eagles in the playoffs. Can the Packers find a solution to reignite their passing game, or are they doomed for an early playoff exit? Tune in for a brutally honest analysis and more!  

Nick and Jonathan discuss the issues with the NBA regular season and how bad their ratings are.

Nick and Jonathan talk about Caris LeVert's role in the Cavs 23-4 start to the season, and they discuss the issues with the NBA regular season. Also, Jonathan tells the story of walking back to his car after a show last week.

Dec. 12, 2024 - Hunger persists as a major problem in New York, so a coalition has come together to push for a package of measures to address food insecurity in the budget. We discuss these solutions with state Sen. Rachel May, a Syracuse-area Democrat, and Ryan Healy, advocacy manager for Feeding New York State.

This week on My Mate Bought a Toaster (the show that goes through people's Amazon accounts for lols) we discover a guest who doesn't really use Amazon.And YET what fun we still have.Honestly, just SUCH a versatile format.We discuss Paris, hair colour, phone breakages, phoning a pizza place AND MORE SO MUCH MORE.Next week - Sara Barron!Until then don't forget to like and subscribeToast xTikTok Instagram YouTube New Episodes every Thursday Hosted on Acast. See acast.com/privacy for more information.

There's a serious issue with the PS5 Pro, which could be the deciding factor, for many, not to upgrade. Should Sony have delayed the console? Or are the game developers at fault here? Will it get better over time? Let's discuss it here!

NBA ratings continued their steep decline during the second week of the season. While Steph Curry and the Golden State Warriors continue to draw good ratings...the rest of the NBA is struggling. We reveal and react to declining NBA ratings. We discuss the variety of issues that are negatively impacting NBA ratings. We also explain why injuries are the biggest problem right now in the NBA...and provide a possible reason as to why the NBA is dealing with so many injuries. USE PROMO CODE BTL10 TO SAVE 10% WITH SOUL DOG USA: https://souldogusa.com

Buffalo Bills security BANS man from wearing MAGA shirt! NFL has a SERIOUS PROBLEM!

Essential Question:How might we empower young entrepreneurs to design solutions for authentic real-world problems?Key Takeaways:Thinking about project based learning or service learning - Does the product or action address an authentic need? Do people want it?Turning ideas into actionCollaboration: Building your teamIf you have enjoyed the podcast please take a moment to subscribe, and also please leave a review on your favorite podcast platform. The way the algorithm works, this helps our podcast reach more listeners. Thanks from IC for your support. Learn more about how Inspire Citizens co-designs customized student leadership and changemakers programsConnect with more stories from the Inspire Citizens network in our vignettesAccess free resources for global citizenship educationYou can book a discovery call with Inspire Citizens at this linkShare on social media using #EmpathytoImpactEpisode Summary On this episode, I connect with Shirah, a young entrepreneur and CEO of NightCap. NightCap, as Shirah describes it, is a fun solution to a serious problem. She shares how having something slipped into your drink is a much more serious problem than many are aware of. This is often due to the fact that most incidents do not get reported. This happened to one of her friends when she was a teenager, and she was inspired to design a product that deters bad actors and also serves as a method of prevention for having your drink tampered with when you are out having fun. With the help of her family, she was able to turn this idea into a successful business. Listen to learn more about her work to design the prototype, her experience on Dragons Den and her aspirations for the future of her business.A big shout out to Magic Mind for sponsoring this episode. Use promo code IMPACTLT20 to get 48% off your first subscription or 20% off a one time purchase.https://magicmind.com/impactltDiscover a transformative podcast on education and learning from a student perspective and student voice, exploring media, media literacy, and media production to inspire citizens in schools through a media lab focused on 21st-century learning, empathy to impact, Global citizenship, collaboration, systems thinking, service learning, PBL, CAS, MYP, PYP, DP, Service as Action, futures thinking, project-based learning, sustainability, well-being, harmony with nature, community engagement, experiential learning, and the role of teachers and teaching in fostering well-being and a better future.

The Knicks entered this season as a championship contender. But after last night's blowout loss to the Celtics, it's clear NY is still far away from being a championship level team. It's only 1 game out of 82, so NY still has plenty of time to correct the issues but the defensive futility we saw from this team, especially from 3 is alarming. The same defensive issues present in preseason have now followed NY into this extremely important season. The issues look extremely similar to what we've seen in the past with Tom Thibodeau coached teams, heavy defense inside with poor defense outside. If NY doesn't correct this situation fast, they could be looking at more than just a slow start... Troy Mahabir breaks all of this down! SHOW CHAPTERS: 00:00 - Intro 00:59 - Knicks Have A Serious Problem 01:52 - NY Perimeter Defense Was Horrible Against Boston 03:31 - Knicks Did Good On Offense Despite The Lackluster Defense 05:03 - NY Needed To Push Into Defense More 06:06 - Knicks Destroyed From The 3 point Line 09:03 - Knicks Chemistry Will Take Time To Come Together 11:13 - Mikal Bridges Defense Is Concerning... 13:57 - Knicks Defensive Schemes Are The Same As Last Year 16:00 - Deuce McBride SHOCKED Everyone With ELITE Shooting 17:37 - KAT Must Be More Aggressive On The Offensive Side 18:51 - OG Anunoby Needed To Provided More On Both Ends 20:28 - Attack The Basket & Good Things Will Happen LISTEN NOW TO GET YOUR KNICKS FIX! Catch the latest special interviews, shorts, fan interactions, and more by following the show! Don't forget to turn on notifications so you don't miss another episode! Rather Watch the latest Knicks Recap episode? Catch us on YouTube here: https://www.youtube.com/@TheKnicksRecap Follow The Knicks Recap on all social media platforms! Twitter: https://twitter.com/TheKnicksRecap Instagram: https://www.instagram.com/TheKnicksRecap/ Reddit: https://www.reddit.com/u/TheKnicksRecap?utm_source=share&utm_medium=android_app&utm_name=androidcss&utm_term=1&utm_content=share_button Facebook: https://www.facebook.com/TheKnicksRecap/ Rather Listen to The Knicks Recap on a different platform? Catch us on ALL of your favorite streaming platforms: Apple Podcast: https://apple.co/3SKSl8o Spotify: https://spoti.fi/3QrEfr6 iHeart Radio: https://www.iheart.com/podcast/269-the-knicks-recap-a-new-yor-100895112/ Amazon Music: https://amzn.to/3QoZrOd Other Pod Channels: https://anchor.fm/the-knicks-recap Grab our MERCH featuring some of the graphics you've seen us create to take your Knicks fandom to the NEXT LEVEL: MAIN STORE: https://theknicksrecap.myspreadshop.com/ CashApp: $TheKnicksRecap Have a comment about the show, an interview, or a graphic idea? Reach out to The Knicks Recap on ALL SOCIAL MEDIA PLATFORMS!

Dennis Prager is a New York Times bestselling author and a nationally syndicated radio talk show host. He writes a weekly column—more than one thousand of which are available on the internet. Equally at home in the secular and religious worlds, he taught religion and history at Brooklyn College and taught the Torah verse-by-verse from the Hebrew for more than twenty-five years. In addition to The Rational Bible, he is the author of, among other books, Happiness Is a Serious Problem; Still the Best Hope: Why the World Needs American Values to Triumph; and Why the Jews?: The Reason for Antisemitism, the Greatest Predictor of Human Evil. He is the co-founder of Prager University (PragerU), an internet site with over a billion views a year. For more about Dennis Prager and for all the resources, visit the PragerU website: PragerU ================================================================ For more about Legacy Dads, click here: Legacy Dads Website Legacy Dads Facebook Group: Legacy Dads Facebook Legacy Dads Instagram: Legacy Dads IG Legacy Dads on X: Legacy Dads X

Larisa Harrington is a mental health expert talking to Lisa Dent about the stresses that often arise around election season. With a whopping 61% who say the presidential election has a hefty negative impact on their mental health, is it any wonder that tensions are high before November 5th?

Digging pits at the beach might seem like fun, but it can turn dangerous fast—those holes can collapse and trap you in seconds if the sand shifts!

Week 4, DONE, and oh man, Nick is PISSED. The boys break down the Jets poor performance vs Denver. Also they break down the Ravens beatdown of the Bills, the Vikings being the hottest team in the NFL, Cowboys squeak by Giants and potential problems brewing in Philly and so much more! Hope you guys enjoy! Follow us on: iTunes, Soundcloud, Spotify, Google Podcasts, IHeartRadio, Instagram @BrotherhoodofPodcasting, on Facebook @ facebook.com/brotherhoodofpodcasting Twitter: @BHPodcasting on Twitch: twitch/tv/flip_nation and TikTok www.tiktok.com/@brotherhoodofpodcasting + FLIP_Nation_Twitch

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Everything seems to be at critical mass and if we stand to allow the current trajectory of it all to take course, we're going to have a problem. Yes, a really big problem. It's time to change course.

Our party plays a nice game of chutes, and ladders this week. Things go poorly for the party. We release new episodes every Wednesday morning! If you want more content from us consider supporting us on Patreon! Please provide any feedback to warplordspod@gmail.com, or Reach out to us on Twitter! We want to hear from you! Warp Lords is a product of Bandit Gang Entertainment, and the game is used with their permission. Buy the game, take the ride! Buy/Download Warp Lords Here Follow our Sosh-Meds! Warp Lords Podcast Tweeter: @WarpLordsPod Warp Lords Tweeter: @Warplords Warp Lords Facebook: Warp Lords Warp Lords Podcast Patreon: Demand an apology Warp Lords Podcast Tik Tok: @warplordspodcast Credits: GM (Alien TTRPG: Heart of Darkness): Graham Banas Birger Hedenstrom: Mike Danger Vautour Tetsu Ejiri: Jared Cryan Noor "Nooj Salad" Sajad: Dillon Morin Music: Jared Cryan Editing: Graham Banas Art: Mike "Danger" Vautour If you like what you heard, then please spread the word. Any characters, items, animals, blob monsters, trees, instruments, bad voices, manic lawyers, power tools, pocket pickles or shitty jokes that bear resemblance to another intellectual property or otherwise non-original content are used in parody or satire or other harmless ways and are in no way related to or a depiction of another subject in or around reality. This is a silly podcast with silly people, and is not intended to be taken seriously by anyone in any way.

A woman was shot by her own twin brother, gun violence in America is a serious problem.. plus more news

Saints hit day number 3 of padded practice out in Irvine and Mike and Bobby dive into the issues we are already seeing on the O-line and again what might the best lineup look like before switching up to the issue causer... Chase Young who is absolutely on fire and looking to parlay his one-year deal into big money down the line.

Today James Kaddis and Tom Hughes will discuss a recent threat made by Saudi Arabia that may set the world in a freefall, and if it happens, we will witness the beginning of what will be the end of America and quite possibly the end of all cash currencies. Every fear related to the takeover of social credit systems and the use of CBDC's may quickly be realized, but there is hope. To support this ministry financially, visit: https://www.oneplace.com/donate/1479/29

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Katharina von Schurbein, the European Commission's Coordinator on Combating Antisemitism and Fostering Jewish Life, talks about the EU's response to anti-Jewish hate crimes and speech. Despite the alarming increase in cases, she says that the Union has taken many measures (some of them long before October 2023) that have begun to bear fruit. This episode is made possible by the Israel office of Konrad-Adenauer-Stiftung, which promotes peace, freedom, and justice through political education.

This week on Knock Knock Eye, I talk about blood in the eye—how it happens and why it matters. Join me, Dr. Glaucomflecken, as I delve into hyphema and vitreous hemorrhage, sharing insights and personal experiences from the medical field. Discover the causes, treatments, and broader implications for healthcare in this engaging episode. — To Get Tickets to Wife & Death: You can visit Glaucomflecken.com/live  We want to hear YOUR stories (and medical puns)! Shoot us an email and say hi! knockknockhi@human-content.com Can't get enough of us? Shucks. You can support the show on Patreon for early episode access, exclusive bonus shows, livestream hangouts, and much more! – http://www.patreon.com/glaucomflecken Today's episode is brought to you by the Nuance Dragon Ambient Experience (DAX). It's like having a virtual Jonathan in your pocket. If you would like to learn more about DAX Copilot check out http://nuance.com/discoverDAX and ask your provider for the DAX Copilot experience. Produced by Human Content Learn more about your ad choices. Visit megaphone.fm/adchoices

In hour four, we discuss the fallout of the Stefon Diggs trade to Houston. Sure, the Bills got worse today but the Texans got significantly better. The Marlins STINK! Plus, the Powerball is at 1 Billion dollars and google has been tracking our incognito searches. 

Builders Collective of Australia President, Phil Dwyer, told Mark Allen and Jimmy Bartel "we've got a very serious problem".See omnystudio.com/listener for privacy information.

Liz O'Donnell, Chair, Road Safety Authority

On today's episode, Javier takes some time to discuss the Padres lack of spending this offseason! After quickly discussing Yu Darvish getting the start for the season-opener in Seoul, he breaks down the team's perceived cheapness with upgrading the edges of the roster, the team's interest in some remaining free agents (Tommy Pham, Adam Duvall, Michael A. Taylor), why the panic over the spending should be tabled for now, next year's free agent class, and more! Go Padres.Follow on Twitter: https://mobile.twitter.com/JaviipenoFollow the show on Twitter: https://mobile.twitter.com/lo_padresFollow the Youtube: https://www.youtube.com/channel/UCGJEwqFeBz_6v5zVWMEUgswSupport Us By Supporting Our Sponsors!eBay MotorsWith all the parts you need at the prices you want, it's easy to turn your car into the MVP and bring home that win. Keep your ride-or-die alive at EbayMotors.com. Eligible items only. Exclusions apply. eBay Guaranteed Fit only available to US customers.GametimeDownload the Gametime app, create an account, and use code LOCKEDON for $20 off your first purchase.FanDuelRight now, NEW customers get ONE HUNDRED AND FIFTY in BONUS BETS – GUARANTEED when you place a FIVE DOLLAR BET. Visit FanDuel.com/LOCKEDON to get started.FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN)

PFAS are known as forever chemicals, and they're really bad for the environment - they never break down, and can spread into waterways, land, animals...and us. Research has also shown that they can be really bad for us, with high exposure also been linked to a various range of health conditions, and a higher risk of some cancers. Larry Acton has been farming cattle for over 50 years, but when he bought his property in 2021, he had no idea it was contaminated with PFAS. He's now seriously worried about his cattle drinking the groundwater, and whether that could make it into the meat, and eventually into consumers. Speaking to The Briefing, the long time cattle farmer shares his concerns, and what he thinks needs to be done about it. Headlines: Nikki Haley drops out of run for Republican presidential nomination ASEAN ends with watered down warning to China  Sam Kerr's alleged slur revealed    Follow The Briefing:Instagram: @thebriefingpodcast Facebook: TheBriefingNewsAUTwitter: @TheBriefingAUSee omnystudio.com/listener for privacy information.

The drop in drink driving has been replaced by drivers on drugs, Garda Commissioner Drew Harris has said.We wanted to find out how commonplace it is, and how the Garda are dealing with the increase in Drug Driving.Henry McKean met motorists and spent time with the Gardai Road Policing Unit.

Going out eating with your toddler son should be fun and enjoyable, but not when you have to deal with people who simply cannot handle a child being a child. Remy gets excited and that ruins your day?!

Detroit Pistons head coach Monty Williams became the latest NBA head coach...to question the officiating in the NBA. Monty Williams unleashed a tirade on NBA officials...after officials cost the Detroit Pistons a win against the New York Knicks. We reveal and react to Monty Williams postgame press conference. We discuss the ongoing problem with the officiating in the NBA. We question if this problem is caused by incompetence...and provide our theory as to why NBA officials have become a serious problem in the league.

As the big phone companies plan big price increases, smaller competitors are taking a bigger share of the marketplace. Clark shares easy ways to keep costs down.  Also, you've heard of getting a second opinion when it comes to medical procedures, but did you know that getting a second opinion in all sorts of consumer areas can save you big bucks? SAVE on Cell Phone Service: Segment 1 Ask Clark: Segment 2 Get A Second Opinion: Segment 3 Ask Clark: Segment 4 Mentioned on the show: Comcast, Charter add subs; survey finds consumers very open to MVNOs T-Mobile Eyes Price Hikes As AT&T, Verizon Set to Raise Rates in March Best Cell Phone Plans in 2024: The Cheapest Plan for Every Need What Is Owner's Title Insurance and Do You Need It? Home Title Lock: Is It the Same As Home Title Insurance? Counterfeit Stamps How getting a second opinion can stop you being ripped off — The Conversation Brushing Scam – United States Postal Inspection Service “Brushing” Scam Indicates a Serious Problem for Victims How Can I Make Freezing a Young Person's Credit Less Risky? Should You Make Your Child an Authorized User on Your Credit Card? Credit Karma Review: Free Credit Score and More at Your Fingertips Clark.com resources Episode transcripts Community.Clark.com Clark.com daily money newsletter Consumer Action Center Free Helpline: 636-492-5275 Learn more about your ad choices: megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices

The Extradition of Julian Assange Threatens Press Freedoms https://www.nytimes.com/2024/02/19/opinion/julian-assange-extradition-espionage.html Links: https://bit.ly/gmllinks WATCH on Youtube: https://bit.ly/3UwsRiv Join the private discord & chat during the show! joingml.com Like our intro song? https://www.3pillmorning.com This episode is sponsored by BetterHelp.  Give online therapy a try at Betterhelp.com/gml and get on your way to being your best self.  Secure your assets and protect your loved ones with Trust and Will. Get 10% off plus free shipping  of your estate plan documents by visiting trustandwill.com/GML Learn more about your ad choices. Visit podcastchoices.com/adchoices

This is serious business we're talking here. If you're not happy, there's a problem. Unfortunately, I want be happy until you share this episode, so please do that. --- Support this podcast: https://podcasters.spotify.com/pod/show/nathandickeson/support

GUEST: Anna from Ukraine - Anna Danylchuk ---------- Anna Danylchuk has been creating a war diary since the early days of the full-scale invasion of Ukraine by Russia in 2022. Anna Danylchuk aims to tell the truth about Ukraine and Russia's war and cut through the noise and propaganda. Anna is passionate about the beauty and independence of her country, and communicates this powerfully in her videos, in a clear and honest way. ---------- LINKS: https://www.youtube.com/@UCiVefOT4TGW3pOqW6AxmlBQ https://www.buymeacoffee.com/annafromukraine My interview with Anna in Lviv - hosted on her excellent channel- https://youtu.be/daHcnsNQ1S0?si=yHbZ2kJZ3CTVRd8Z ---------- OTHER VIDEOS WITH ANNA ON SILICON CURTAIN: https://youtu.be/x0o1bn-1Yyc https://youtu.be/Hm5_Yb3geQ4 https://youtu.be/x-gUSUG7N6E https://youtu.be/r0PNxM7Xyow https://youtu.be/5AenntkSxIs https://youtu.be/vPT6oZ1FOAw https://youtu.be/0gaK_5TEXXw https://youtu.be/XQJoTAAfxt4 ---------- SUPPORT THE CHANNEL: https://www.buymeacoffee.com/siliconcurtain https://www.patreon.com/siliconcurtain ---------- TRUSTED CHARITIES ON THE GROUND: Save Ukraine https://www.saveukraineua.org/ Superhumans - Hospital for war traumas https://superhumans.com/en/ UNBROKEN - Treatment. Prosthesis. Rehabilitation for Ukrainians in Ukraine https://unbroken.org.ua/ Come Back Alive https://savelife.in.ua/en/ Chefs For Ukraine - World Central Kitchen https://wck.org/relief/activation-chefs-for-ukraine UNITED24 - An initiative of President Zelenskyy https://u24.gov.ua/ Serhiy Prytula Charity Foundation https://prytulafoundation.org NGO “Herojam Slava” https://heroiamslava.org/ kharpp - Reconstruction project supporting communities in Kharkiv and Przemyśl https://kharpp.com/ NOR DOG Animal Rescue https://www.nor-dog.org/home/ ---------- PLATFORMS: Twitter: https://twitter.com/CurtainSilicon Instagram: https://www.instagram.com/siliconcurtain/ Podcast: https://open.spotify.com/show/4thRZj6NO7y93zG11JMtqm Linkedin: https://www.linkedin.com/in/finkjonathan/ Patreon: https://www.patreon.com/siliconcurtain ---------- Welcome to the Silicon Curtain podcast. Please like and subscribe if you like the content we produce. It will really help to increase the popularity of our content in YouTube's algorithm. Our material is now being made available on popular podcasting platforms as well, such as Spotify and Apple Podcasts.

We Have A Serious Problem, The Growing Rise Of Psychopathic Behavior In The US | CJS Highlights https://www.audacy.com/989word The Charlie James Show   Listen on Spotify : https://spoti.fi/3MXOvGP Apple Podcasts: https://podcasts.apple.com/us/podcast/the-charlie-james-show-podcast/id1547262821   Follow us on Social Media Join our Live Stream Weekdays - 3pm to 7pm   Facebook: https://www.facebook.com/989word Rumble: https://rumble.com/c/c-2031096 X: https://twitter.com/989word Instagram: https://www.instagram.com/989word/   "Red Meat, Greenville." 01/24/24

Emma told 3AW's Jacqui Felgate she applied for a two-bedroom property in Hawthorn which was advertised for $675 a week. She was shocked by what she was told when she called the agent to follow up on her application.See omnystudio.com/listener for privacy information.

The end of the year typically brings a number of FDA approvals, and 2023 is no different. Last week, the Food and Drug Administration approved a new drug, Augyro (repotrectinib) for the treatment of patients with ROS1-positive non-small cell lung cancer.  Also making oncology headlines this week, is an expert update on the cancer drug shortage, research about how the severity of diabetes can impact colorectal cancer outcomes and how vitamin D may be able to mitigate the severity of chemotherapy-induced peripheral neuropathy.   FDA Approves Augtyro for Patients With NSCLC Subset Another week, another FDA approval. This time, the agency approved Augtyro for the treatment of patients with locally advanced or metastatic ROS1-positive non-small cell lung cancer.  The drug works by targeting ROS1 oncogene fusions, which can be responsible for the growth of cancer. The approval was based off findings from the phase 1/2 TRIDENT-1 clinical trial, which showed that 79% of patients responded to therapy with the drug, including 6% who experienced a complete response, which is when all signs of cancer disappear.  Bristol Myers Squibb, the pharmaceutical company that manufacturers Augtyro, expects the drug to be available to patients in mid-December.  FDA Approves Keytruda plus Chemo for Advanced HER2-Negative Gastric, GEJ Cancers Also in FDA news last week, the agency approved the immunotherapy drug, Keytruda, in combination with chemotherapy for the treatment of patients with advanced unresectable or metastatic HER2-negative gastric or gastroesophageal junction adenocarcinoma.  The approval came after findings from the KEYNOTE-859 trial showed that the immunotherapy-chemo combination improved overall survival) that's time from treatment until death of any cause); progression-free survival (time from treatment until death or disease worsening) and response rate compared to a group that received placebo plus chemotherapy.  FDA Approves Truqap Plus Chemo for Some With HR-Positive, HER-Negative Breast Cancer Additionally, the FDA has approved Truqap with chemotherapy fulvestrant for the treatment of adults with HR-positive or HER2-negative locally advanced or metastatic breast cancer with one or more PIK3CA/AKT1/PTEN-alterations and who have progressed on at least one endocrine-based regimen in the metastatic setting or recurred at or within one year of completing adjuvant therapy. And now this approval was based on the results of the CAPItello-291 trial where among patients with these altered tumors, the median progression free survival was 7.3 months in the Truqap and chemotherapy cohort and 3.1 months in the placebo and chemotherapy cohort. FDA Approves Xtandi for High-Risk Prostate Cancer And the FDA approved Xtandi for the treatment of patients with non-metastatic castration-sensitive prostate cancer, with a high risk of biochemical recurrence, meaning a recurrence that is determined by rising prostate specific antigen levels. According to Pfizer, the manufacturer of the drug, and notably, this marks the first approval of an androgen receptor signaling inhibitor that is FDA approved for this patient population.  The approval is based on findings from the randomized phase 3 EMBARK clinical trial were five-year metastasis free survival, which is the time from treatment until metastatic disease was 87.3% in the Xtandi arm, compared with 71.4% and the leuprolide-only group and 80% in the monotherapy group, according to findings that were published in the New England Journal of Medicine.  Drug Shortages Continue to Be a ‘Serious Problem' in Oncology While the shortage of the chemotherapy drugs, cisplatin and carboplatin, seems to be improving, drug shortages, in general, are not a new problem and likely are not going anywhere soon, according to Corey McEwen, the director of oncology pharmacy services at Massachusetts General Hospital in Bostin.   McEwen explained that most of these drugs are manufactured outside of the United States. The FDA will approve certain locations to make the drugs, which then are shipped to the wholesaler, then the cancer treatment center or clinic and finally, to the patients. However, at no point during that process is there an obligation to be transparent about drugs that are in shortage or at risk to be in shortage.  Additionally, with increased demand and decreased supply, the price of these therapies can go up. At Mass. General, McEwen said that the institution will oftentimes take on the financial burden of the increased cost, because they are mainly focused on getting the drugs in the first place. However, that may not be the case in all cancer treatment centers, leading to more disparities and financial burdens from cancer care.  Diabetes Severity Associated With Poor Colorectal Cancer Survival Research published in the journal, Cancer, analyzed outcomes for patients with diabetes and colorectal cancer who underwent surgery for their cancer. Findings showed that patients with more severe diabetes tended to have poorer survival outcomes. This was particularly the case for patients who were female or in their earlier stages of cancer.  The researchers theorized that the relationship between diabetic severity and cancer prognosis may be explained by three mechanisms:  ·      Diabetes can lead to increased levels of insulin-like growth, which can accelerate tumor growth  ·      High blood sugar levels may result in poor response to chemotherapy  ·      The potential increased accumulation of genetic mutations that result from the high inflammatory burden caused by diabetes  Vitamin D May Help Prevent Chemo-Induced Neuropathy Once again, vitamin D made oncology headlines last week. This time, findings published in the Journal of the National Comprehensive Cancer Network found that patients who were deficient in vitamin D before starting treatment with paclitaxel had higher rates of chemotherapy-induced peripheral neuropathy than patients with sufficient vitamin D levels.  Peripheral neuropathy is a common side effect from certain types of chemotherapy drugs that presents as numbness, tingling or a stabbing feeling in the hands and/or feet. Eventually if the neuropathy gets so bad, patients can have a higher risk of falls or become unable to perform some essential everyday tasks, such as preparing food or getting dressed. There is currently no cure for the condition, so potential prevention or mitigation strategies — like getting enough vitamin D — are particularly important.  I spoke with study author Dr. Dan Hertz who said that while more research is needed in this space, it is worth it for patients to check their vitamin D levels and take a supplement, if needed. 

In this episode, hosts Amanda and Trina, along with guest Manuwella Allen (Mani), discuss gender equity in education, with a focus on the intersection of race and gender. They address issues of sexual harassment and abuse in schools, highlighting several disturbing cases. The conversation covers the lack of attention given to gender equity in education, the need for a more intersectional approach, and the importance of implementing Title IX. They also discuss the adultification of black girls' bodies, the problematic nature of dress codes, and the structural sexism in the teaching profession. The episode emphasizes the urgent need for change in the American public education system. Check out the show notes here: https://amandawritenow.com/courageous-teachers-speak-out-against-a-serious-problem-being-overlooked-in-k-12-schools/ Check out our affinity space and join here: https://www.ssasv.org/ Nonsexist Dress Code :https://noworegon.org/issues/model-student-dress-code/ Girl Up Student Club/Union:https://girlup.org/

Chess tournaments have always had draws, but sometimes these draws seem too convenient and prearranged. Is making a draw quickly in chess ever OK? What role do draws play in chess culture? GM Jesse Kraai, IM David Pruess, and IM Kostya Kavutskiy get to the bottom of this in today's episode of the Dojo Talks podcast! Interested in improving? Check out the Dojo Training Program: https://chessdojo.club  Chess is more than a game, it's a lifestyle. Live it with ChessDojo merch: https://www.chessdojo.club/shop Want to support the channel? Donate here - https://streamelements.com/chessdojol... Find all of our chess book recommendations (& more!) on our Amazon storefront: https://www.amazon.com/shop/chessdojo Follow ChessDojo here: Website: https://chessdojo.club Twitch: https://twitch.tv/chessdojolive Discord: https://discord.gg/sUUh8HD Twitter: https://twitter.com/chess_dojo Patreon: https://patreon.com/chessdojo Instagram: https://www.instagram.com/chess_dojo/ Podcast: https://chessdojotalks.podbean.com/ 0:00 Intro 2:51 Jesse's  Confession 7:25 David's Take on Jesse's Draw 12:10 Chess Draw Culture 14:38 Match Fixing in Chess 24:26 The Art of Draws 30:48 Draws in Norm Events 42:16 The Fight Against Quick Draws 51:14 Quick Draw for a Norm 56:07 Post-podcast chat

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The combination of warmth and humidity in Missouri make it a fantastic place … for ticks. We learn what makes the state even more hospitable to these bloodsucking insects and how we can protect ourselves from tick-borne maladies like alpha-gal syndrome, which makes people allergic to red meat. We also get an update on the nearly 100 illegally transported Antilles pinktoe tarantulas that've been living at the Missouri Botanical Gardens Butterfly House since they were seized by federal agents in February.

Kevin Durant and Devin Booker have been amazing in the NBA playoffs but it's becoming clear they have a big problem. The Suns will not win a championship until they address the issue and this is a look at what the franchise must do this offseason.

Zion Williamson will not play for at least the Pelican's Play-In game because he doesn't “feel like Zion.” This caused a lot of fans to get angry at the young star but he's got an even bigger problem than that now.