Podcasts about Substance P

Back pain is a common health condition affecting millions of people worldwide, decreasing their quality of life and productivity. Traditional treatments often provide temporary relief, prompting the search for innovative therapies. Peptide therapies have shown promising results in addressing back pain.  In this podcast, we'll talk about the common causes of back pain, traditional treatments used to treat back pain, and peptide therapies used for back pain management. What causes back pain? If you've had lower back pain, you know how debilitating it can be (e.g., affecting your quality of life and making it hard to work, exercise, or partake in extracurricular activities). Often, the exact cause of pain isn't understood, but most cases of low back pain come on suddenly and go away within one month. Typically, the pain comes from the spine or the ligaments and muscles around the spine. This is common in those with muscle strains or sprains of the muscles or ligaments around the spine from mild trauma or repetitive physical activity.  People who have serious medical conditions can also experience back pain. A few common causes could be arthritis of the spine (spondylosis), herniated disc (bulging disc), spinal stenosis (when the space around the spinal cord narrows, causing pain, numbness, or tingling in the legs. How can I make my back pain stop? If your back is bothering you, there are some treatments that you can try at home to help lessen the pain. Non-strenuous activity:  Although you're in pain and you may want to stay in bed when you have back pain, it's important to know that this can make the pain worse. It helps to try activities like walking and gentle stretching. Over-the-counter (OTC) medications: You might be able to help relieve acute back pain with OTC anti-inflammatory medications like naproxen or ibuprofen. These medications block the body's production of prostaglandins (natural chemicals) that trigger pain, swelling, and inflammation. Heat or ice: It's hard to know when to use heat vs. ice for back pain. The rule of thumb is to start with ice when your back hurts after a minor injury. You can use ice packs, cold towels, and ice baths. You can try this for 2 days and then move to heat. Heat helps with pain by increasing blood flow to help relax your muscles and help the body to repair injured tissue. Heat will not only help with pain but can also help with stiffness to loosen up your back muscles. This, in turn, helps with your mobility to get you back to living a normal life. For heat, you can apply hot water bottles to the area of pain. You can also use hot towels, heating pads, and saunas.  If you have back pain that lasts more than one month or occurs with symptoms like severe numbness or weakness in the legs, inability to urinate, or numbness in the groin, talk to a healthcare provider. Never try to treat back pain at home if your pain is caused by a major trauma or injury (e.g., car accident or fall) or a previous spinal procedure (e.g., surgery or injections). Peptides for back pain BPC-157- BPC 157, or Body Protection Compound 157, is a peptide derived from stomach acid. It works by decreasing inflammation and increasing blood flow to damaged tissues. It speeds up the healing of wounds, tendons, ligaments, bone injuries, your nervous system, and even the digestive tract.  LL-37- LL-37, a naturally occurring antimicrobial peptide, exhibits potent anti-inflammatory properties. Chronic back pain often results from inflammation of spinal nerves and surrounding tissues. LL-37 mitigates inflammation, providing relief to patients suffering from conditions like sciatica and herniated discs. By modulating the immune response, LL-37 promotes healing and reduces pain. Thymosin Beta-4 (TB4)-  Thymosin Beta-4 is a peptide used for cellular regeneration. It plays a pivotal role in tissue repair and wound healing. In the context of back pain, TB4 aids in regenerating damaged spinal discs and muscles, offering long-term relief.  It works by binding actin (proteins that make up 10% of the total proteins in cells). Actin helps with cell division, signaling, and shape. It also speeds up the rate of new tissue growth and new blood vessel formation. TB4 also helps wounds heal. Melanocortin Peptides- Melanocortin peptides, including Melanotan II, have shown promise in managing chronic pain conditions. These peptides work by modulating the body's pain perception pathways, providing relief to individuals suffering from persistent back pain. By interacting with melanocortin receptors, these peptides alter neurotransmitter levels, effectively reducing pain signals transmitted to the brain. Substance P Inhibitors- Substance P is a neurotransmitter associated with pain perception. Peptide therapies targeting Substance P receptors can effectively alleviate back pain by inhibiting nerve sensitivity. By blocking these receptors, these peptides reduce the transmission of pain signals, offering relief to patients with conditions like neuropathic back pain. Peptide therapies represent a groundbreaking approach to back pain management, offering hope to individuals whose lives are hindered by chronic discomfort. As research in this field continues to advance, peptide therapies are set to revolutionize the way we treat back pain, providing a brighter future for millions who suffer from back pain.  Note: Always consult with a healthcare professional before undergoing any peptide therapy to ensure safe and effective treatment. Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week! Pro Tips We're huge advocates of using daily greens in your routine to help with gut, skin, nail, bone, and joint health. We take AG1 (athletic greens) every day. Not only does it have vitamins, minerals, and a diverse range of whole-food sourced ingredients, but it also has probiotics to promote a healthy gut microbiome and adaptogens to help with focus and mood balance. It's vegan, paleo, and keto-friendly.  

Fibromyalgia is a condition which presents with symptoms of chronic widespread pain, fatigue, depression, lower abdominal pain, and other cognitive symptoms. Dr Irene explains the possible causes of this condition including the latest research, and details some of the available treatments. KEY TAKEAWAYS Sensitivity to pain is a variable factor influenced by the genetics, environment, stress hormones, sleep disturbance and previous life experiences such as accidents or injury. Fibromyalgia is described as a disorder of painprocessing due to how pain signals are processed in the central nervous system differently in each patient. In patients with fibromyalgia their spinal fluid has more Substance P, a neurotransmitter and a modulator of pain perception which alters cellular signalling pathways. Psychological treatments including Cognitive Behavioural Therapy help as well as lifestyle treatments such as increased exercise, relaxation and treatments for anxiety and depression. Vitamin treatments of benefit include Magnesium Glycinate, Coenzyme Q10, Boswellia, and Melatonin. Medications such as Amitriptyline, SNRI's and Tramadol can also be effective. BEST MOMENTS ‘We know in fibromyalgia there are familial predispositions.' ‘Our brain also has another pain switching off system as well. So when it's too heightened we've got a system that slowly inhibits by bringing it down.' ‘One of the major things about fibromyalgia is that it is really related to sleep dysfunction.' ‘When people do not go into stage 3 and stage 4 they do not get the restorative sleep where you get a lot of healing process going on.' VALUABLE RESOURCES Join Patreon : http://www.patreon.com/drireneching Instagram: irene.ching.777 Tiktok: @ireneching777 Youtube channel: Dr Irene Ching Twitter: @ireneching7777 Clubhouse: @ireneching1 https://www.facebook.com/irene.ching.735 LinkedIn : https://www.linkedin.com/in/irene-ching-742623219 ABOUT THE HOST Dr Irene Ching is a medical practitioner who specialises in Family Medicine, Wealth and Life Coach, Property/ Business Investor, Speaker, and Podcaster : Be Happy, Healthy and Wealthy. Dr Ching speaks on health, wellness and wealth in talks, workshops and events. She has her own coaching programme on money mindset - Quantum Wealth Creation Accelerator (online course with weekly coaching). She approaches health and well-being in a holistic way and encourages people to look at all the areas of their lives. In her coaching sessions, she works with emotional freedom techniques, energy works, NLP, Intuition/ Superconscious mind, Inner child healing, Timeline therapy, Self love works, behavioural change, goal settings and money attraction healing. Her motto: Reset Your Mind, Reset Your life. The podcast Be Happy Healthy and Wealthy is aimed at people who wants to be high achievers who perform at their peak performance in all aspects of life. It is about how we could be happy regardless of our circumstances, and to understand the secrets to real health and wealth; especially how to live a prosperous long life. She has been interviewing successful entrepreneurs, keynote speakers, influencers and millionaires on this important subject. So stay tuned to get the deep dive on how to be happy, healthy and wealthy- the million dollar questions!          

44 years experience in jaw orthopedics, dental medicine, and functional jaw orthodontics....let's welcome Dr. Dwight Jennings DDS to the podcast.  In this episode we are talking all about jaw alignment, the trigeminal nerve, substance P and what that means for our overall health. Can jaw alignment be the potential answer for non dental related issues? Find out in this episode.Timestamps to help you navigate this episode:(0:00) Intro(3:32) Who is Dr. Dwight Jennings, DDS?(7:44) Autoimmune, asthma & jaw alignment(11:08) Trigeminal nerve(13:36) Substance P(16:56) Children and modern orthodontics vs. Dr. Jennings' approach(25:25) Sponsor: Snap Supplements 25% OFF using code LUNDEN25(28:01) Wisdom teeth removal and jaw alignment(37:04) The connection between bite and conditionFREE Self Love & Sweat Monthly Life Coaching Calendar: http://lifelikelunden.com/calendar FREE ACCESS 15-day #BreatheBeforeYouScroll Breathwork & Mindfulness Challenge: https://lifelikelunden.com/breatheOne-On-One Life Coaching & NLP with Lunden:http://lifelikelunden.com/vipConnect with Lunden:IG: @lifelikelundenYouTube: https://youtube.com/lundensouzaLinkedIN: https://www.linkedin.com/in/lundensouza/Twitter: @lifelikelundenUse code LUNDEN25 for 25% off Snap Supplements: https://bit.ly/snapsweat

Dr Dwight Jennings is not your typical orthodontist. Most dentist and orthodontist treat your jaw and mouth from a very superficial lens, meaning they want your teeth to look straight cosmetically, using things like Invisalign or sleep guards that only help you sleep. However, Dr Jennings looks at the mouth in a very holistic manner. Not only does he fix your mouth so that it cosmetically looks nice, but he uses special retainers to help move your lower jaw forward. This helps move the jaw forward so that you're biting tip to tip. Most dentists leave you with a bit of an overbite or don't even correct the overbite. Dr Jennings has also been studying Substance P for years and is probably the world's leading expert, which he goes into great detail in our full length podcast interview. Substance P can be the cause of overall inflammation in your body, i.e. leaky gut, allergies, learning issues, aggression/anger, autoimmune conditions, firbromylgia, seizures, vitiligo, autism, and much more. I discovered Dr Jennings, because I was a healthy individual, but at age 30 I started snoring. After three appts with him, my snoring stopped. I asked him, "Dr J, why don't I just buy a mouthpiece to sleep with that moves my jaw forward to stop snoring, instead of always wearing a mouthpiece 24/7?" Dr Jennings told me that you can buy a mouthpiece to help your sleep, but it'll never fix your Substance P issues, long term health issues, jaw pain and TMJ. Dr Jennings is a master when it comes to solving jaw pain and TMJ. I've been seeing Dr Jennings for almost three years to help reorganize my mouth as not only did I have an overbite, but I also had an upper jaw that was not landing correctly on my lower jaw. My experience so far has been amazing and I can't recommend him enough. Recently, my six year old boy was having “aggression” issues and I was noticing he was mouth breathing a lot and had lots of sinus issues. I recently brought him to see Dr Jennings and after only three-four treatments I've already seen a decrease in his aggression. Now, my wife and I have also done a lot of other things to help change the way we parent, just check out my interview with Toscha Shore to learn more, but I truly believe Dr Jennings' work has helped out immensely. I notice my son snorts his nose a lot less than he used to. Timeline:2:45 - Why Dr Jenning's type of orthodontistry is different4:10 - What is Substance P and why it really matters for your health7:30 - How can you quantify Substance P9:00 - Why your bite and jaw alignment correlate so closely with Substance P16:45 - Why have our jaws de-evolved and degenerated in the last 200 years21:30 - Substance P and how it relates to COVID-1922:50 - How diet relates to our poor jaw health25:30 - How your teeth can still grow even as adults28:45 - My experience with my six year old boy34:04 - How Substance P can effect skin melanocytes and reverse vitiligo36:10 - Could lowering Substance P reverse cancer?37:50 - The jaw and athletic performance41:00 - The jaw and posture47:12 - Why the sensory system is so crucial to health

Dr Dwight Jennings is not your typical orthodontist. Most dentist and orthodontist treat your jaw and mouth from a very superficial lens, meaning they want your teeth to look straight cosmetically, using things like Invisalign or sleep guards that only help you sleep. However, Dr Jennings looks at the mouth in a very holistic manner. Not only does he fix your mouth so that it cosmetically looks nice, but he uses special retainers to help move your lower jaw forward. This helps move the jaw forward so that you're biting tip to tip. Most dentists leave you with a bit of an overbite or don't even correct the overbite. Dr Jennings has also been studying Substance P for years and is probably the world's leading expert, which he goes into great detail in our full length podcast interview. Substance P can be the cause of overall inflammation in your body, i.e. leaky gut, allergies, learning issues, aggression/anger, autoimmune conditions, firbromylgia, seizures, vitiligo, autism, and much more. I discovered Dr Jennings, because I was a healthy individual, but at age 30 I started snoring. After three appts with him, my snoring stopped. I asked him, "Dr J, why don't I just buy a mouthpiece to sleep with that moves my jaw forward to stop snoring, instead of always wearing a mouthpiece 24/7?" Dr Jennings told me that you can buy a mouthpiece to help your sleep, but it'll never fix your Substance P issues, long term health issues, jaw pain and TMJ. Dr Jennings is a master when it comes to solving jaw pain and TMJ. I've been seeing Dr Jennings for almost three years to help reorganize my mouth as not only did I have an overbite, but I also had an upper jaw that was not landing correctly on my lower jaw. My experience so far has been amazing and I can't recommend him enough. Recently, my six year old boy was having “aggression” issues and I was noticing he was mouth breathing a lot and had lots of sinus issues. I recently brought him to see Dr Jennings and after only three-four treatments I've already seen a decrease in his aggression. Now, my wife and I have also done a lot of other things to help change the way we parent, just check out my interview with Toscha Shore to learn more, but I truly believe Dr Jennings' work has helped out immensely. I notice my son snorts his nose a lot less than he used to. Timeline:2:45 - Why Dr Jenning's type of orthodontistry is different4:10 - What is Substance P and why it really matters for your health7:30 - How can you quantify Substance P9:00 - Why your bite and jaw alignment correlate so closely with Substance P16:45 - Why have our jaws de-evolved and degenerated in the last 200 years21:30 - Substance P and how it relates to COVID-1922:50 - How diet relates to our poor jaw health25:30 - How your teeth can still grow even as adults28:45 - My experience with my six year old boy34:04 - How Substance P can effect skin melanocytes and reverse vitiligo36:10 - Could lowering Substance P reverse cancer?37:50 - The jaw and athletic performance41:00 - The jaw and posture47:12 - Why the sensory system is so crucial to health

In this Episode of The Human Upgrade™… Dave talks with Rachelle Copeland about putting her energy into healing facial injuries and building new tissues—starting with the central nervous system. Rachelle experienced an accident that injured her face, teeth, nerves and jaw. She wants to heal quickly and avoid scarring and long-term damage while also managing the accompanying emotional trauma.This intervention looks at ways to heal and recover both internally and externally, covering suggestions such as: EMDR, Tapping, EFT for physical and emotional trauma (What Is EMDR and How Does It Work?, Nick Ortner: The Tapping Solution for Pain Relief – #219, Tap into Tapping: The EFT Episode – Dawson Church # 474)Jaw misalignment (Dr. Dwight Jennings: TMJ, Jaw Pain, & Substance P – #179)Vagal nerve (Stephen Porges: The Polyvagal Theory & The Vagal Nerve – #264, The Nervous System Circuitry of Safety, Sound & Gratitude – Stephen Porges #573)Hyperbaric therapyCraniosacral workInflammationOral and topical cayenneRed and infrared, LED or laser light therapy Ozone therapySupplements to support healingEnzymesIf you're recovering from injury, take a listen to this episode for tips and resources on how to heal.Note: The "Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT! Vascular System Protection https://calroy.com/dave, save up to 45% on a 3-pack to protect your blood vessels from vulnerable plaqueGet Fit in Five Minutes: https://www.carolbike.com, use code HumanUpgrade to get 2 years of free membership (a total savings of $360) on the CAROL Bike 2.0 and a 100-day home trial. Learn more: How to Hack Your Cardio Workout – Ulrich Dempfle– #9789th Annual Biohacking Conference: Come join like-minded people June 22-24 in Orlando, Florida, for three days of awesome! You'll learn from dozens of experts at an amazing event that's designed to upgrade every area of your life.https://biohackingconference.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.14.516867v1?rss=1 Authors: Barde, S., Aguila, J., Zhong, W., Solarz, A., Mei, I., Prud'homme, J., Palkovits, M., Turecki, G., Mulder, J., Uhlen, M., Nagy, C., Mechawar, N., Hedlund, E., Hokfelt, T. Abstract: BACKGROUND: Major depressive disorder (MDD) is a serious disease and a burden to patients, families and society. Rodent experiments and human studies suggest that several neuropeptide systems, including substance P(SP)/tachykinin, neuropeptide Y(NPY) and their G protein-coupled receptors are involved in mood regulation.METHODS: We assessed the transcript levels (qPCR) of SP/tachykinin and NPY systems in five regions from postmortem brains of male and female depressed subjects who committed suicide (DSS) and controls: dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC), the dorsal raphe nucleus (DRN), locus coeruleus (LC) and medullary raphe nuclei (MRN). We also analysed human LC neurons isolated using LCM with Smart-seq2 RNA sequencing. RESULTS: Transcripts for all nine members were detected in male and female controls with marked regional variations of the raw CT values and with the highest levels for several tachykinin and tachykinin receptor transcripts in the DRN and for NPY and NPYR transcripts in the PFC regions. Significant sex differences for controls were recorded only in the DRN (NPYR2 greater than in females) and LC (TAC3 and NPY greater than in females). Elevated expression in DSS was recorded in (i) DLPFC for SP, TAC and TAC3 in females, SP in males, and NPYR1 in both sexes; and (ii) LC for all tachykinin family transcripts in females, SP, TACR1 and TACR3 in males, NPY in both sexes, and NPYR1 in males. CONCLUSIONS: The selective perturbation of neuropeptide systems in MDD patients may assist in the search for novel treatment strategies for subjects afflicted by this grave disorder. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Part 2 of how NUTRITION has a HUGE impact on your BRAIN! Everything in your brain is something you ate, something you made from something you ate, or, in a few cases, something your mother ate. Nutrition impacts your mental and emotional health, the function of your five senses, and your conscious and unconscious control over your body movements. Join me as I lead you in a safari through the textbook, “Neuroscience,” pointing out along the way all the interesting connections to nutrition. Listen in for part 2 on the NEUROTRANSMITTERS! 0:00:37     Cliff Notes 0:04:15     Overview of neurotransmitters 0:06:55     Glutamate is the primary excitatory neurotransmitter. 0:14:08      De novo glutamate in the central nervous system is overwhelmingly made from glucose. 0:16:55     Ketogenic diet for epilepsy 0:20:12    Glutamate metabolism 0:23:42    There are two classes of glutamate receptors: ionotropic and metabotropic. 0:24:45     There are three classes of metabotropic glutamate receptors, their actions are complex and variable, and they can be excitatory or inhibitory. 0:25:05     The ionotropic glutamate receptors include AMPA receptors, NMDA receptors, and kainite receptors, all of which have a depolarizing effect by allowing sodium and potassium to flow freely through them. 0:27:47     Four unique things about the NMDA receptor: magnesium is required to block its ion channel, it's important for coincidence detection, it allows calcium to come into the cell, and it has a glycine-binding site. 0:33:16     Long-term potentiation (LTP) and long-term depression (LTD) are important for forming memories, and glutamate receptors play an important role. 0:40:48     GABA and glycine are the two primary inhibitory neurotransmitters of the central nervous system. 0:44:04     GABA and presumably glycine can be stimulatory if there is more chloride on the inside of the neuron than the outside. 0:48:53     Evidence that GABA might cross the blood-brain barrier 0:51:44     GABA in foods 0:54:14     GABA metabolism in the nervous system 0:56:08     Glycine 1:02:02     Acetylcholine 1:07:50     The biogenic amines include histamine, serotonin, and the catecholamines (dopamine, norepinephrine, and epinephrine). 1:08:30     Synthesis of the catecholamines 1:10:46     Dopamine 1:14:08     Norepinephrine 1:16:32     Histamine 1:20:15     Serotonin 1:23:10     ATP and adenosine 1:26:38     Peptide neurotransmitters 1:27:00     Hypothalamic releasing hormones include thyrotropin-releasing hormone (TRH), corticotropin-releasing hormone (CRH), and gonadotropin-releasing hormone (GnRH). 1:29:15     Melanocyte-stimulating hormone (MSH) 1:29:32     Oxytocin 1:30:18     Vasopressin 1:30:57     Synthesis of the neuropeptides Substance P, MSH, oxytocin, and vasopressin requires glycine, zinc, copper, and vitamin C. 1:34:24     Endocannabinoids and the importance of arachidonic acid, EPA, and DHA Nutrition in Neuroscience Related Content Chris Masterjohn Lite: Could Oxaloacetate Supplements Help With Glutamate Sensitivity? Chris Masterjohn Lite: 5 Ways to Help With Glutamate Sensitivity and Glutamate Dominance Chris Masterjohn Lite: Does Glycine or GABA Wake You Up? Chris Masterjohn Lite: Carbs or Keto for Sleep? Chris Masterjohn Lite: How to Manage Your Magnesium Status Mastering Nutrition: Why You Need Glycine -- A Panel Discussion Balancing Methionine and Glycine in Foods: The Database  Chris Masterjohn Lite: Get Better Sleep With Glycine Start Here for Methylation has glycine and choline resources, and covers the methylation process used in the synthesis and degradation of biogenic amines. Mastering Nutrition: Methylate Your Way to Mental Health With Dopamine The Pursuit of Happiness: How Nutrient-Dense Animal Fats Promote Mental and Emotional Health, covers the endocannibinoids. Testing Nutritional Status: The Ultimate Cheat Sheet is a comprehensive guide for testing nutritional status for all the nutrients discussed in this episode, and more. Use the code MASTERINGNUTRITION for $5 OFF. Nutrition in Neuroscience Research The textbook, Neuroscience. Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. on the use of GABA for fear of heights and to alter anxiety- and focus-related brain waves. γ-Aminobutyric acid (GABA) administration improves action selection processes: a randomised controlled trial on use of GABA to improve decision-making under pressure. Desarrollo de un pan de masa madre rico en GABA y péptidos IECA contains a table on the GABA content of foods on page 84 of the PDF. Acetylcholinesterase inhibitor from plants on the different plants containing natural acetylcholinesterase inhibitors. A Mass Spectrometry-Based Method to Screen for α-Amidated Peptides on the neuropeptides that require glycine, vitamin C, copper, and zinc for their biological activity. Effects of copper occupancy on the conformational landscape of peptidylglycine α-hydroxylating monooxygenase also on the neuropeptides that require glycine, vitamin C, copper, and zinc for their biological activity.

Dr Dwight Jennings is not your typical orthodontist. Most dentist and orthodontist treat your jaw and mouth from a very superficial lens, meaning they want your teeth to look straight cosmetically, using things like Invisalign or sleep guards that only help you sleep. However, Dr Jennings looks at the mouth in a very holistic manner. Not only does he fix your mouth so that it cosmetically looks nice, but he uses special retainers to help move your lower jaw forward. This helps move the jaw forward so that you're biting tip to tip. Most dentists leave you with a bit of an overbite or don't even correct the overbite. Dr Jennings has also been studying Substance P for years and is probably the world's leading expert, which he goes into great detail in our full length podcast interview. Substance P can be the cause of overall inflammation in your body, i.e. leaky gut, allergies, learning issues, aggression/anger, autoimmune conditions, firbromylgia, seizures, vitiligo, autism, and much more. I discovered Dr Jennings, because I was a healthy individual, but at age 30 I started snoring. After three appts with him, my snoring stopped. I asked him, "Dr J, why don't I just buy a mouthpiece to sleep with that moves my jaw forward to stop snoring, instead of always wearing a mouthpiece 24/7?" Dr Jennings told me that you can buy a mouthpiece to help your sleep, but it'll never fix your Substance P issues, long term health issues, jaw pain and TMJ. Dr Jennings is a master when it comes to solving jaw pain and TMJ. I've been seeing Dr Jennings for almost three years to help reorganize my mouth as not only did I have an overbite, but I also had an upper jaw that was not landing correctly on my lower jaw. My experience so far has been amazing and I can't recommend him enough. Recently, my six year old boy was having “aggression” issues and I was noticing he was mouth breathing a lot and had lots of sinus issues. I recently brought him to see Dr Jennings and after only three-four treatments I've already seen a decrease in his aggression. Now, my wife and I have also done a lot of other things to help change the way we parent, just check out my interview with Toscha Shore to learn more, but I truly believe Dr Jennings' work has helped out immensely. I notice my son snorts his nose a lot less than he used to. Timeline:2:45 - Why Dr Jenning's type of orthodontistry is different4:10 - What is Substance P and why it really matters for your health7:30 - How can you quantify Substance P9:00 - Why your bite and jaw alignment correlate so closely with Substance P16:45 - Why have our jaws de-evolved and degenerated in the last 200 years21:30 - Substance P and how it relates to COVID-1922:50 - How diet relates to our poor jaw health25:30 - How your teeth can still grow even as adults28:45 - My experience with my six year old boy34:04 - How Substance P can effect skin melanocytes and reverse vitiligo36:10 - Could lowering Substance P reverse cancer?37:50 - The jaw and athletic performance41:00 - The jaw and posture47:12 - Why the sensory system is so crucial to health

Are you ready to come to the jaw-dropping realization that your bite is the culprit of practically all your body ailments?  I’m joined by rebel dentist Dr. Dwight Jennings, who brings over 25 years of vigorous independent research and countless case studies addressing TMJ and a flurry of other health issues that are consistently misdiagnosed by modern doctors and dentists. We’re talking everything from headaches, scoliosis, and cancer to mental dis-eases and fertility issues — all caused by jacked-up Substance P levels in your system.  I was left open-mouthed in awe at the mind-blowing connections that Dr. Dwight Jennings has made between jaw alignment and our physical and mental wellbeing. As you’ll discover, this goes way beyond orthodontics and is deeply rooted in lifestyle, diet, and our exposure to EMF.  If you can’t book a session with Dr. Dwight anytime soon, you can catch him in action in the bonus episode of my live dental exam.   09.14 — Unpacking Dr. Dwight Jennings’s Approach to Dentistry  His rebel approach to jaw orthopedics What TMJ stands for and how symptoms can manifest    11:04 – Decoding Substance P and its effects on our body What it is and how it’s linked to fibromyalgia, migraines, and localized pain The flaws in lab test standards  The issue with nightguards Why jaw alignment is crucial for optimum brain function   09.14 — How a Modern Diet Messed Up Our Mouths  How an industrialized diet has wreaked havoc with our head-jaw relationship  Why cosmetic correction doesn’t cure the root cause How future generations are affected by this trend Examining the relationship between the Trigeminal nerve, jaw placement, and brain fog   28:22— The Medicine & Dentistry Dilemma  The lack of communication between doctors and dentists  Big pharma’s influence on Substance P research  Why Invisalign and braces won’t cure cranium mandibular disorders (even after they ‘fix’ your teeth)   34:59 - The Correlation Between Jaw Health and Illness The connection between bite issues and scoliosis, osteopenia, and osteoporosis How high levels of Substance P increases calcium influx in your body, causing fatigue, recurrent illness, and cancer Why your bite issues make you hypersensitive to the environment Jaw dysfunction–the root cause of headaches and migraines   Decreasing Substance P levels with spices, alternative medicine, and exercise  Curing Tinnitus, loss of hearing and ear infections through jaw alignment therapy   53:45 — The Relationship Between Substance P and Stem Cell Differentiation Why researchers believe Substance P is the sole cause of Leukemia Dr. Jenning’s case studies of using bite therapy to treat dental lymphoma, leukemias, and myeloma Behavior issues, addiction, and Substance P   01:02:48 — The Treatment Process How Dr. Dwight Jennings approaches treatment with his patients A closer look at the appliance used to aid jaw correction The cost and timeframe of treatment More about this episode.   JOIN MY NEW ONLINE EMF HOME SAFETY MASTERCLASS! Visit www.lukestorey.com/emfmasterclass to join. Only $149! Are you aware of the dangers of EMF exposure in your home, but have no idea where to start when it comes to finding, and fixing them?  Are you concerned about your exposure to the current 3G, 4G, and 5G wireless networks now activated in most major cities? Have you attempted to test the levels yourself using EMF meters you found online and ended up confused and frustrated? EMFs (electromagnetic frequencies) are one of the most toxic elements in our living and work environments. Due to the technical nature of accurately testing for them—and the training required to do so properly—many of us resign ourselves to the fact that we just have to accept them and the consequences they bring in order to use the modern technology we depend on. But you don’t have to. In this seven-part video documentary series, you will follow world-renowned building biologist Brian Hoyer as he tests an entire home, room by room, to determine the source and level of every known type of EMF. By the end of this series, you will not only be thoroughly educated on the various types and sources of EMF commonly found in homes but also of the many mitigation tools and techniques available thanks to the cutting-edge technologies. Visit www.lukestorey.com/emfmasterclass to join. Only $149!   Connect with Luke on social media to learn how to take your lifestyle to the next level, plus catch exclusive live interviews & events: INSTAGRAM - @lukestorey // https://www.instagram.com/lukestorey/ FACEBOOK - https://www.facebook.com/MrLukeStorey/ TWITTER - @MrLukeStorey // https://twitter.com/MRLUKESTOREY YOUTUBE - https://www.youtube.com/c/LukeStorey   THIS SHOW IS BROUGHT TO YOU BY: JUST THRIVE. Imagine this: a probiotic that actually does what it is supposed to do! I’ve tried so many different supplements, and when you find the right one — the one that really works — it’s like winning the lottery. So I was psyched when I tried Just Thrive Probiotic, the first and only spore-based probiotics and antioxidants. Their products have been the subject of groundbreaking clinical studies and demonstrated incomparable effects on the gut, even healing leaky gut. It’s super simple and it just works. You can use code ‘luke15’ for 15% off at thriveprobiotic.com/luke.   AND...   BEEKEEPER'S NATURALS. Superfoods from the hive - amazing! Beekeeper’s Naturals brings you the highest quality products from the hive and nurture a greater awareness for saving our bees! That is why their all-natural health-boosting products are made with the purest ingredients from sustainable apiaries full of healthy bees. Each of their products has been rigorously tested to meet the highest potency standards. Use code “LIFESTYLIST” for 15% off at beekeepersnaturals.com/lukestorey.   AND…   SOVEREIGNTY. Just when I think I’ve discovered every herb and supplement in the known universe, another two come along and get my attention: Purpose and Dream from sovereignty.co. I’ve been taking them daily for a while now and they’re making a huge difference. Purpose is great for daytime alertness and focus, while Dream is meant for nighttime relaxation and restful sleep. And these guys stand behind their herbal products so much that they offer a Your Favorite Money Back Guarantee. So, if you don’t like their products, they will give you your money back and buy you your favorite supplement. You can find Purpose and Dream at sovereignty.co/luke. HELP SUPPORT THIS SHOW! Love the Show? You’ll really love Luke’s Master Market Online Store!  It’s a win/win! Get direct links to all of Luke’s hand-picked biohacking and health products all in one place, get exclusive discounts, and support the show by making purchases through the web store >> SHOP NOW.   Other ways to support:  SUBSCRIBE >> Apple Podcasts + Stitcher + Google Podcasts + Spotify LEAVE APPLE PODCASTS REVIEW >> Simple step-by-step instructions SHARE >> Spread the word! Tell your family, friends, neighbors, and all your social pals   Resources tmjoakland.com parkinsonstmj.com dwightjennings.com   Related Shows Episode 321: Dr. Dwight Jennings Bonus Show: Luke’s Shocking Dental Exam

This audio feed of my dental exam with Dr. Dwight Jennings gives you a glimpse into the niche category of dentistry no one else is talking about. But if you can watch it on YouTube or Instagram, I recommend checking out the video because this is a very visual episode. This stuff will shock you to your core! With so much information, I decided to dedicate two entire episodes to his ground-breaking work on jaw alignment and body ailments. Spoiler alert: pretty much everything wrong with your body is linked to your jaw, and no brace or a night guard can fix it (you’ll see how I learned the hard way with that one). Be sure to listen to the previous episode for an in-depth breakdown of Dr. Dwight Jennings’s professional background and work around Substance P levels and our physical and mental health. Trust me, your mouth’s going to hit the floor with this one.   02:31 — Dr. Dwight Jennings Diagnostic Process The unique mechanics Dr. Dwight Jennings night guard  Why it makes sense for our jaw to be ‘tip to tip’ Biomechanical analysis of jaw muscles  My individual diagnosis    07:08 —The Consequences of Molar Removal How lack of molar support depletes body functionality levels Jaw alignment and wisdom teeth removal The drawbacks to mainstream TMJ therapy  PGOcclusion.com   10:19 - The Process to The Perfect Bite What an ideal bite looks like  The Pivoting Mechanics approach How an overactive temporalis muscle leads to gallbladder dysfunction  The benefits of using polyvinyl siloxane instead of carbon paper to check teeth alignment The real reason your teeth are eroding   18:13 - Why Your Night Guard is Your Enemy Current controversies surrounding the cause of TMJ The best way to measure bite registration   23:21 — The Ailment and Alignment Connection Examining body pain and digestion with jaw alignment How high Substance P levels are the root cause of your suffering The link between Substance P and Autism   More about this episode. Watch it on YouTube.   JOIN MY NEW ONLINE EMF HOME SAFETY MASTERCLASS! Visit www.lukestorey.com/emfmasterclass to join. Only $149! Are you aware of the dangers of EMF exposure in your home, but have no idea where to start when it comes to finding, and fixing them?  Are you concerned about your exposure to the current 3G, 4G, and 5G wireless networks now activated in most major cities? Have you attempted to test the levels yourself using EMF meters you found online and ended up confused and frustrated? EMFs (electromagnetic frequencies) are one of the most toxic elements in our living and work environments. Due to the technical nature of accurately testing for them—and the training required to do so properly—many of us resign ourselves to the fact that we just have to accept them and the consequences they bring in order to use the modern technology we depend on. But you don’t have to. In this seven-part video documentary series, you will follow world-renowned building biologist Brian Hoyer as he tests an entire home, room by room, to determine the source and level of every known type of EMF. By the end of this series, you will not only be thoroughly educated on the various types and sources of EMF commonly found in homes but also of the many mitigation tools and techniques available thanks to the cutting-edge technologies. Visit www.lukestorey.com/emfmasterclass to join. Only $149!   Connect with Luke on social media to learn how to take your lifestyle to the next level, plus catch exclusive live interviews & events: INSTAGRAM - @lukestorey // https://www.instagram.com/lukestorey/ FACEBOOK - https://www.facebook.com/MrLukeStorey/ TWITTER - @MrLukeStorey // https://twitter.com/MRLUKESTOREY YOUTUBE - https://www.youtube.com/c/LukeStorey   HELP SUPPORT THIS SHOW! Love the Show? You’ll really love Luke’s Master Market Online Store!  It’s a win/win! Get direct links to all of Luke’s hand-picked biohacking and health products all in one place, get exclusive discounts, and support the show by making purchases through the web store >> SHOP NOW.   Other ways to support:  SUBSCRIBE >> Apple Podcasts + Stitcher + Google Podcasts + Spotify LEAVE APPLE PODCASTS REVIEW >> Simple step-by-step instructions SHARE >> Spread the word! Tell your family, friends, neighbors, and all your social pals   Resources tmjoakland.com parkinsonstmj.com dwightjennings.com   Related Shows Episode 320: TMJ, Jaw Pain, Substance P: The Missing Link in Dentistry w/ Dr. Dwight Jennings

In this episode of Bulletproof Radio, I get into inflammatory responses and the lessons pain teaches us with my guest, Dr. David Liepert. “COVID is doing damage by overwhelming us and causing uncontrolled inflammation,” he says. “The inflammatory response to COVID is actually somewhat protective. The question is, at what point does it become counter-protective, or even counterproductive, or even producing injury? The same thing is true systemically, that, for instance, social distancing and quarantine are kind of a social form of inflammation.”“Basically, uncontrolled inflammation is another way to think of a cytokine storm,” he says. “Cytokines are meant to be the solution, but uncontrolled, they literally become the thing that's killing us, rather than helping us get better.”Dr. Liepert a physician with a broad range of expertise in critical care, specialty anesthesiology, and quality improvement and assessment programs within Canada’s healthcare system. He’s dedicated much of his professional work to helping patients find solutions to chronic pain. He also serves as chief medical officer and advisor to several companies leading development and discoveries for mobile health and wellness monitoring, and AI solutions.I asked him to talk more about how this type of virus (Covid-19) is bringing our health systems down, not just us individually.“My one big struggle with academic medicine and the way it responds to situations like this is, academic medicine assumes we know what questions to ask,” Dr. Liepert says. “And if we don't even know what question to ask, we're never going to find the right answer.”Enjoy the show! And get more resources at https://blog.daveasprey.com/category/podcasts/.

In this episode of Bulletproof Radio, I get into inflammatory responses and the lessons pain teaches us with my guest, Dr. David Liepert. “COVID is doing damage by overwhelming us and causing uncontrolled inflammation,” he says. “The inflammatory response to COVID is actually somewhat protective. The question is, at what point does it become counter-protective, or even counterproductive, or even producing injury? The same thing is true systemically, that, for instance, social distancing and quarantine are kind of a social form of inflammation.”“Basically, uncontrolled inflammation is another way to think of a cytokine storm,” he says. “Cytokines are meant to be the solution, but uncontrolled, they literally become the thing that's killing us, rather than helping us get better.”Dr. Liepert a physician with a broad range of expertise in critical care, specialty anesthesiology, and quality improvement and assessment programs within Canada’s healthcare system. He’s dedicated much of his professional work to helping patients find solutions to chronic pain. He also serves as chief medical officer and advisor to several companies leading development and discoveries for mobile health and wellness monitoring, and AI solutions.I asked him to talk more about how this type of virus (Covid-19) is bringing our health systems down, not just us individually.“My one big struggle with academic medicine and the way it responds to situations like this is, academic medicine assumes we know what questions to ask,” Dr. Liepert says. “And if we don't even know what question to ask, we're never going to find the right answer.”Enjoy the show! And get more resources at https://blog.daveasprey.com/category/podcasts/.

Massage  What are the benefits and risks and more importantly, how can it help normal people like us LAUNCH into our lives positively, personally & professionally? In this episode we will be digging into why it is important and maybe even crucial to start implementing a regular massage protocol into our weekly practices, the numerous benefits it has not only on your mind but also chemically as well as the benefits it has for our Super Powers cognitively and socially.    Certain cultures are considered “High Contact” cultures such as France and it is also possible for humans to become “Touch Hungry” where lack of human touch and interaction could lead to depression and also impair communication skills as your voice could potentially fall flat. Americans are the least likely to “touch” one another when socially interacting Humans also suffer from “Skin Hunger” or “Touch Hunger” Researchers have shown that touch can communicate a range of emotions, serving as an important social tool, and even the act of hugging can reduce your levels of the stress hormone cortisol Among the many benefits of simple human touch and more importantly massage therapy are those related to the body's production and regulation of neurohormones.  These are the hormones produced by the nervous system that affect an individual's behavior and general overall wellbeing.  Several studies have demonstrated the benefits of massage in boosting serotonin. It's not clear to me whether it is massage in particular, or simply physical human touch The Vagus Nerve  Can you explain to me how touch—specifically massage—affects the nervous system? What happens is you're stimulating pressure receptors and vagal activity increases. Vagus is one of the 12 cranial nerves, and it has a lot of branches all over the body from the gastrointestinal system and the heart to our vocal chords and so forth. We have measured vagal activity and that increases, and with that, you get a decrease in cortisol, the stress hormone. There's an increase in serotonin, which is the body's natural antidepressant and anti-pain chemical. You get a decrease in Substance P, that senses pain. We consider yoga a form of self-touch, self-massage, rubbing your limbs against the floor or the ground, and we get very similar effects. I would guess that if you looked at fast walking, a lot of different exercises, you'll see very similar effects. When you're walking, you're stimulating the pressure sensors in your feet. The rubz ball or golf ball

Lo studio del fenomeno biologico del movimento ortodontico ha assunto un ruolo da protagonista nella ricerca scientifica legata all'ortodonzia.Ne sono di esempio i due articoli che presentiamo nella puntata di oggi, che parlano di modulazione del movimento ortodontico mediante modulazione della risposta infiammatoria e di fenomeno di riassorbimento radicolare (apice o superficie radicolare? Ascolta la puntata!)Il cambio di paradigma è indispensabile se vogliamo aprire la strada a nuove idee nel campo della ricerca e guardare al nostro lavoro di tutti i giorni con occhi nuovi.PRIMO ARTICOLO:An, Shu et al.Effect of systemic delivery of Substance P on experimental tooth movement in ratsAmerican Journal of Orthodontics and Dentofacial Orthopedics , Volume 155 , Issue 5 , 642 - 649LINK:https://doi.org/10.1016/j.ajodo.2018.05.026SECONDO ARTICOLO (GUEST EDITORIAL):Naphtali Brezniak, Atalia WassersteinRoot resorption revisited: The paradigm of force effect on root resorption: Is a ‘paradigm shift' needed in order to learn more about the phenomenon?.The Angle Orthodontist: May 2019, Vol. 89, No. 3, pp. 518-520.LINK:https://doi.org/10.2319/0003-3219-89.3.518 *******Autori del podcast:Dr. Tito Mattia BordinoDr.ssa Thea Tromby

Lo studio del fenomeno biologico del movimento ortodontico ha assunto un ruolo da protagonista nella ricerca scientifica legata all'ortodonzia.Ne sono di esempio i due articoli che presentiamo nella puntata di oggi, che parlano di modulazione del movimento ortodontico mediante modulazione della risposta infiammatoria e di fenomeno di riassorbimento radicolare (apice o superficie radicolare? Ascolta la puntata!)Il cambio di paradigma è indispensabile se vogliamo aprire la strada a nuove idee nel campo della ricerca e guardare al nostro lavoro di tutti i giorni con occhi nuovi.PRIMO ARTICOLO:An, Shu et al.Effect of systemic delivery of Substance P on experimental tooth movement in ratsAmerican Journal of Orthodontics and Dentofacial Orthopedics , Volume 155 , Issue 5 , 642 - 649LINK:https://doi.org/10.1016/j.ajodo.2018.05.026SECONDO ARTICOLO (GUEST EDITORIAL):Naphtali Brezniak, Atalia WassersteinRoot resorption revisited: The paradigm of force effect on root resorption: Is a ‘paradigm shift' needed in order to learn more about the phenomenon?.The Angle Orthodontist: May 2019, Vol. 89, No. 3, pp. 518-520.LINK:https://doi.org/10.2319/0003-3219-89.3.518 *******Autori del podcast:Dr. Tito Mattia BordinoDr.ssa Thea Tromby

Feeling Melancholy? General malaise is an aftermath of the lunar eclipse. How to quickly disrupt your brain from sadness. Brief mention of Ralph Smart and his Infinite Waters channel on YouTube. I cover many ways to gain natural pain relief using various methods to help alleviate pain of migraines, headache, muscle aches or pains and spasms, and arthritis. How to activate Substance P in the brain and disrupt the pain receptors using jalapenos. Spicy foods vs. Pain. Diet and health suggestions. Forward Head Posture: how to stop hunching over like Mr. Burns! Essential oils, nut oils to reduce inflammation, heat and ice, magnesium and potassium, and the DIY Chiropractic tricks and Osteopath tips using paper cups, tennis balls and duct tape! :)

Part 2 of how NUTRITION has a HUGE impact on your BRAIN! Everything in your brain is something you ate, something you made from something you ate, or, in a few cases, something your mother ate. Nutrition impacts your mental and emotional health, the function of your five senses, and your conscious and unconscious control over your body movements. Join me as I lead you in a safari through the textbook, “Neuroscience,” pointing out along the way all the interesting connections to nutrition. Listen in for part 2 on the NEUROTRANSMITTERS! Get all four episodes right now, ad-free, and with transcripts. Sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code “CHRIS15” at checkout for a 15% discount off your first order.” In this episode, you will find all of the following and more: Nutrition in Neuroscience Show Notes 00:36 Cliff Notes 10:15 Overview of neurotransmitters 12:55 Glutamate is the primary excitatory neurotransmitter. 20:08 De novo glutamate in the central nervous system is overwhelmingly made from glucose. 22:55 Ketogenic diet for epilepsy 26:12 Glutamate metabolism 29:42 There are two classes of glutamate receptors: ionotropic and metabotropic. 30:45 There are three classes of metabotropic glutamate receptors, their actions are complex and variable, and they can be excitatory or inhibitory. 31:04 The ionotropic glutamate receptors include AMPA receptors, NMDA receptors, and kainite receptors, all of which have a depolarizing effect by allowing sodium and potassium to flow freely through them. 33:47 Four unique things about the NMDA receptor: magnesium is required to block its ion channel, it’s important for coincidence detection, it allows calcium to come into the cell, and it has a glycine-binding site. 39:16 Long-term potentiation (LTP) and long-term depression (LTD) are important for forming memories, and glutamate receptors play an important role. 46:48 GABA and glycine are the two primary inhibitory neurotransmitters of the central nervous system. 50:04 GABA and presumably glycine can be stimulatory if there is more chloride on the inside of the neuron than the outside. 54:52 Evidence that GABA might cross the blood-brain barrier 57:43 GABA in foods 01:00:14 GABA metabolism in the nervous system 01:02:07 Glycine 01:08:01 Acetylcholine 01:13:49 The biogenic amines include histamine, serotonin, and the catecholamines (dopamine, norepinephrine, and epinephrine). 01:14:30 Synthesis of the catecholamines 01:16:45 Dopamine 01:20:07 Norepinephrine 01:22:31 Histamine 01:26:14 Serotonin 01:29:10 ATP and adenosine 01:32:37 Peptide neurotransmitters 01:32:59 Hypothalamic releasing hormones include thyrotropin-releasing hormone (TRH), corticotropin-releasing hormone (CRH), and gonadotropin-releasing hormone (GnRH). 01:35:14 Melanocyte-stimulating hormone (MSH) 01:35:31 Oxytocin 01:36:18 Vasopressin 01:36:56 Synthesis of the neuropeptides Substance P, MSH, oxytocin, and vasopressin requires glycine, zinc, copper, and    vitamin C. 01:40:23 Endocannabinoids and the importance of arachidonic acid, EPA, and DHA

When it comes to testing, you can always count on a lively debate about how to best identify food sensitivity and intolerance. In this interview we review recent clinical and mechanistic research on the ALCAT test, including studies conducted by Yale School of Medicine and other institutions. In addition, general advice will be given about how food testing can help integrative practitioners create personalized diets for health and performance for their patients. About the Expert Roger Deutsch is the CEO of Cell Science Systems, where he oversees research and general management. He has been involved with all aspects of the development of ALCAT technology for 34 years. He previously studied psychology at the State University of New York, Purchase and Chinese medicine at the International College of Oriental Medicine in the United Kingdom. He is coauthor of the book, Your Hidden Food Allergies Are Making You Fat, and has lectured in more than 25 countries on the topics of food, inflammation, and the aging process. He is deeply involved in supporting free education for impoverished girls and free healthcare in rural India. About the Sponsor Cell Science Systems, Corp (CSS) is a CLIA licensed lab and an FDA registered medical device establishment that has developed the ALCAT test for food and chemical sensitivities, as well as GI function assays, telomere length assessments, molecular diagnostics, and this month will also be launching cellular tests for the assessment of functional micronutrient deficiencies and antioxidant status. CSS received the company of the year award in 2016 for Food Intolerance Testing, North America, by Frost & Sullivan. The ALCAT test has been clinically validated in research at the Yale School of Medicine, where mechanistic studies were also conducted. Those studies have led to new discoveries regarding the pathogenic mechanisms underlying food sensitivities. CSS will continue to participate in industry grant–funded, cross-border, translational research that focuses on the role of food-induced release of DNA and its role in pathology. CSS is located in Deerfield Beach, FL, and also operates a wholly owned subsidiary lab in Potsdam, Germany. Transcript Karolyn Gazella: Hello. I'm Karolyn Gazella, the publisher of the Natural Medicine Journal. Today, our topic is Identifying Food Sensitivity and Intolerance. I'd like to thank Cell Science Systems, who is the sponsor of this topic. My guest is Roger Deutsch, who is one of the pioneers in the field of food and chemical sensitivity testing. Roger, thank you so much for joining me. Roger Deutsch: Thank you, Karolyn. Pleasure to be here. Gazella: Well, historically, it's been kind of challenging to identify food sensitivities and intolerances in patients. Generally speaking, I'm just wondering, why is that? Does the research you've participated in offer any new understandings? Deutsch: Yeah, the research that I've been involved in certainly does offer a lot of new understandings. Just to put this in context, and just to repeat, I'm sure most people are very clear on this distinction between allergy and intolerance. Just for sake of brief review, the term allergy was coined by a physician named von Pirquet in 1906 to denote an altered reaction. Then there was quite a bit of debate amongst allergists in Europe during the '20s and '30s as to what should be included in that definition of an altered reaction. At the end of the day, they settled on including only those types of reactions that induced an immediate symptom onset, because those are more definable. Just through some research in the '30s where they transferred serum from an allergic patient to a non-allergic patient and then scratch test the area where the serum transfer took place, and they would induce the wheal-and-flare. They knew that there was some factor in the serum that caused allergy. They didn't know what it was. They called it reagent. Then, years later, in 1969, they found out reagent was IgE. Then they found out all the events that were preceding the IgE molecule and then how the IgE molecule bound to mast cells and then cross linked, which caused degranulation and release of histamine and medium symptoms and so forth. Later, interestingly, they found out that's the same pathway the body uses to protect against infections with worms. So they called that allergen. Of course, worms are large compared to a cell, so when the immune system has to combat such a big pathogen, it's a very dramatic reaction, so there's a very dramatic release of histamine. The symptom onset, then, is very dramatic and very rapid. Then that being as clear as it was, by contrast, intolerances or sensitivities due to an enzyme deficiency or some other part of the immune system, the innate immune system underlining a sensitivity was more difficult because the symptom onset wasn't immediate. The linkage between cause and effect was ambiguous, obscure, and the pathway was unknown, so what do you look for? A lot of different things were proposed. Before too long, people proposed looking at the white blood cell. In the 1950s, an allergist in El Paso named Black reported his usage of looking at white blood cells through a microscope, being challenged with an allergen and seeing morphological changes that then were correlated with clinical symptoms. Then that work got picked by some researchers from Washington University named, gosh. I forgot what their name is. I don't know. It will come to me later, but anyway, they gave it the name cytotoxic test. They published about three or four papers, and it became very popular and broadly used. There was a lot of political upheaval because it's something that came on that proposed a solution to a lot of problems. People don't like huge paradigm shifts, so it fell a little bit by the wayside. We knew that there was a white blood cell component to the thing, which is logical. The immune system would underline an immune reaction. It's no mystery. When we came along, we thought, "Look. The allergists don't like the cytotoxic test." Bryan was the name, William and Marian Bryan brought out the cytotoxic testing. Allergists get upset about it, because it maybe changes the paradigm in ways they were afraid of. It was subjective, because it required a technician to look at cells under a microscope and make a judgment call as to whether or not there was a reaction. We came along in that period of time, in the mid-'80s and applied electronic instrumentation to the measurement of the cells and introduced some other standards, better controls over the allergen presentation and used the computer to interpret the degree of change in the white blood cells. We went along quite a long time observing and making the clear association that when the white blood cells would expand or degranulate or didn't become [inaudible 00:05:48], now we know undergo apoptosis or necrosis or pyroptosis, there was good clinical correlation. We did studies in the late '80s with people who were pioneers, and had backgrounds in research and drug companies even that were interested in this field. We found that when you had an ALCAT, the name of our technology was ALCAT. When you had an ALCAT positive and if you challenged the person with the food that was positive under double blind conditions, you would get correlation about 80% of the time. When there was an ALCAT negative, you would get correlation, in other words, no clinical response from a double blind challenge, about 85% of the time. That was good clinical validation. It was building the mechanism. If you fast forward to earlier this year and last year, there had been a number of clinical studies in between, of course, but we gave the technology to be investigated to some very smart people at Yale School of Medicine. They did a clinical study that they know how to do, a randomized, controlled, double blind, placebo-controlled trial, feeding patients either a diet that was based on the ALCAT test, eliminating positive foods or placebo group, and nobody knew who was in what group except the one coordinator who didn't tell until the end, a placebo diet based on an ALCAT test where they kept the positive foods in. They just looked at change in symptom scores over time. They saw a huge difference between the people following the true experimental diet versus the ones following the placebo. Then they looked at some chemistries. They actually banked serum at the beginning of the study, knowing that retrospectively, they'd see who had done well. Then they could go and evaluate what might have happened amongst that population that had a strong response. They did find that, out of about 1,200 or so peptides and proteins that they assayed, that neutrophil elastase would drip precipitously in those people. Clearly, the neutrophil seemed to have some effect. They went on and did some look into what's happening inside the cell, and which subtypes of leukocytes were most involved. They did immunological studies using flow psychometry and they found that eosinophils were activated most of the time. Neutrophil elastase was being released, so obviously, there was some orchestration between these two classes of granulocytes, but the other thing they found, which is very interesting, is that there was greater release of DNA from the cells that had reacted in a positive way than there were, excuse me, reacted to a food that was tested as positive versus when there was no food in that sample or an ALCAT-negative food. Somehow, the positive reaction would induce the peripheral leukocytes to undergo some sort of process that would result in the release of toxic mediums like neutrophil elastase and others, but would also cause a release of cellular DNA. That's an interesting finding, because over the last few years, most people are not familiar with this yet, but common sense tells you DNA doesn't belong outside the cells. It belongs either nicely tucked away in a eukaryotic cell in the nuclei or in the mitochondria. When it gets out, it can cause problems. We could talk all day about how it gets out, but there's some very smart research from Max Planck Institute, which shows that these neutrophils and macrophages and other granulocytes use, as a strategy to kill pathogens, something called ETosis. When it applied to neutrophils, it's called NETosis. Even after this cell has released free radicals, then it's to try and defend against invaders. Even though the cell is dead, a lot of the nuclear material, the histones, the DNA, merge with granules and the toxic mediators inside and the plasma membranes and the internal membranes and strip out, form these nets. That can trap pathogens, and the DNA is toxic, and kills them. That's occurring, but if too much of this goes on and the body's mechanism for cleaning up the mess, which is mostly DNA's want, and you have the persistence of this toxic DNA in the circulation, excuse me. It causes all sorts of problems, like metabolic problems, like lupus, like arthritis, and even cancer. It's a new area of medicine, so it's interesting. We've found that the ALCAT predicts the foods that trigger the release of DNA. Now we have the next step ahead of us, using a grant that we received from one of the larger industry players, we're going to characterize the nature of the DNA that's released, because the nuance here is that if the DNA is methylated, it's not toxic. If the DNA is unmethylated, it is very toxic. We want to look at that. The expectation is that we'll find that it is mostly unmethylated, because the release of DNA is kind of chaotic and not controlled. Gazella: That is fascinating. I have you tell you, you're talking about the 2018 study that was published in Alternative and Complementary Therapies? Deutsch: No, this study was, it came out Yale. Gazella: It was earlier this year? Deutsch: Yeah, I can't remember the actual name of the journal right off the top of my head. Gazella: Okay. Deutsch: If people go on to CellScienceSystems.com, there are a couple of papers from Yale. The first one I spoke of was a clinical paper. That was published in EMJ Gastroenterology. The other one was another nice, international journal. Gazella: Great. I do want to talk about the study that was published in Alternative and Complementary Therapies, but I want to stay on this topic that you just introduced, because honestly, it's fascinating to me. I think our readers will find it fascinating as well. Right now, can we draw clinical conclusions that ALCAT can be used to predict which foods might increase the release of potential unmethylated DNA, or is that down the road? Is that a clinical application right now, or is that something that is down the road? Deutsch: I think the clinical utility has been established a long time ago from the studies from back in the late '80s where they did these double blind and placebo-controlled oral challenges very carefully and found overall efficacy of the test at 84-plus percent. There's been other studies, one that you just mentioned that also came out in last month's Complementary and Alternative Medicine with some work done at University of Northern Illinois. There, of course, they found some other pathways and some other mechanisms. They found that Serum Amyloid A, which is reflective of overall body inflammation, also drops precipitously in people who have clinical improvement when they alter diet based on ALCAT, much more so than control groups, where you have blinded sham diets being implemented. Another validation just came out last week. This was on European Society of Clinical Nutrition and Metabolism. There was a group from the University of Pavia, which is northern Italy. The University itself was established in the 900s or the 800s. It's a very old institution, very well-respected in Europe. They found that with respect to gluten, isolated gluten, the 33-mer peptide that you can buy from chemical companies that are used in a lot of tests, some tests, and gluten-containing grains, wheat, oats, barley and rye, that the ALCAT test and double blinded placebo-controlled oral challenges with gluten and grains was also very highly correlated. They proposed, at the University, that ALCAT actually be used as a new diagnostic criterion for non-celiac gluten sensitivity. Gazella: Yeah. There's a lot of solid research showing the clinical efficacy of using the ALCAT test. That's what I'm hearing from you regarding the research that's been done up to this point. Deutsch: Yep. It's pretty clear. Gazella: Great. Good. I want to step back a little bit. How common are sensitivities and intolerances to specific foods? Deutsch: That's always a challenging question, because we don't have a clear-cut definition. Intolerances are generally induced by a lack of an enzyme to break down some component of a food, and we have an adverse reaction that may not be that severe, so lactase deficiency can induce lactose intolerance. If you bring those in, but then you get into the more nuanced types of intolerances where there's a chemical that is naturally occurring in a food or could be added in processing where the person lacks the enzyme to break down that toxin. Again, keeping in mind that all plants produce natural toxins in order to defend against pests. Nowadays, I think we see the inability of individuals to break down some of those toxins and the innate immune system comes into play, because we're increasingly depleting and compromising our ability to detoxify. Again, because of some overall changes in diet and how food is produced, the industrialization of farming and so forth. You might find that because the body is not as efficient as it should be, breaking down a toxin the food with which the person has not had, through his ancestry, the development of those detoxification pathways, that if they have a little bit, it's okay. If they have too much, it becomes a problem or if it's the wrong time of year and there's too many other co-factors or they visited Mexico and have a disruption in their diet, then they have more of an issue with it. It's not as clear-cut as, say, an allergy where just a few molecules of the offending substance can trigger a very dramatic response. It actually gets amplified by things like Substance P in the body and spreads out, because it's a whole different pathway and a whole different animal entirely. It depends how you want to try and define these intolerances and sensitivities. People fluctuate, depending on season, detoxification pathways, intestinal permeability, overall level of health, cofactors and so forth. If you are comfortable with a generalization, I'd say that it's very rare. We have found some, but we've had to look hard. It's very rare to find a person who doesn't have any sensitivities or intolerances. In how many? Again, it depends how you operationally define them, but it's highly relevant. It underlies a lot of inflammatory problems, metabolic syndrome and all the health issues that can come from that. It's extremely common, but I don't want to put a number on it, because we're all guessing. Gazella: Yeah. That's interesting. It's rare to find someone who doesn't have a sensitivity or an intolerances. That's a pretty big statement. I'd like to talk specifically about celiac disease and non-celiac gluten sensitivity. Tell us about testing regarding those issues. Deutsch: Celiac disease is an autoimmune disorder where cytotoxic T lymphocytes attack the enterocytes in the small intestine. In order for that to happen, the T lymphocytes have to recognize the allergen or trigger. The trigger, it's not really an allergen. The trigger is gluten. It's presented to the T lymphocyte by an antigen-presenting cell, mostly dendritic cells, which absorb the trigger, break down the peptides internally and lysosomes, transport it by an MHCT molecule to the surface where if there are T cells that recognize that complex, will become activated and may lead to celiac. Celiac depends upon the ability of the T lymphocytes to recognize the combination of that MHCT molecule with the gluten and gliadin peptides. If you're not genetically, if you don't have the genes to produce that specific variation of an MHCT molecule, you can not get celiac disease, so the tests for those genes, which are human leukocyte antigen GA DQ2.5 and H. They're very easy to test through PCR. We also do that testing. That test has phenomenal negative predictability. If you don't have those genes, you cannot get celiac. However, you could still have an adverse reaction to gluten, which is not mediated by the T lymphocytes and that pathway, but it is a function of the innate immune system, which means neutrophils, eosinophils, mostly neutrophils. That's what we call non-celiac gluten sensitivity. That's what they studied in Pavia and found that the ALCAT test is measuring the activation of the granulocytes, which are mostly peripheral granulocytes, mostly neutrophils. The same thing was seen years ago with Fezzano and Stroup, working with the people at NIH in leukocyte biology labs where they challenged with gluten in experimental animals in transgenic mice whose neutrophils would glow when they became activated. They saw all this activation. It's the same pathway, but it goes further in those people who are genetically predisposed. If you go past the first lines of defense of the innate immune system and reach into the specific immune systems, T lymphocyte population becoming active, that causes the real problem. Gazella: I see. ALCAT is actually effective for both food sensitivity and food allergy. Deutsch: I wouldn't say it's effective for food allergy, because I wouldn't call celiac disease really a food allergy, because there's no IBE molecule. Again, the allergists only like to use the word allergy when there's IgE involved or there's an immediate symptom onset. Here, you do have other immunological reactions, more like a Type 4 reaction, whereas an allergy, in the Gell and Coombs system, is a Type 1 reaction. ALCAT will let you know whether you're going to have a problem with gluten. Exactly how that problem will manifest will depend upon many factors, your genetics and also your microenvironment, your ecology in your gut. The ALCAT will tell you both those issues, but not what we call a true food allergy with a Type 1 type of reaction. Gazella: Right, okay. Good point. Good clarification. Let's dig into that 2018 study that was published in the Journal of Alternative and Complementary Therapies. Can you describe the objective, the method, and the outcomes of that study? Deutsch: Going from memory, I don't have that in front of me. It was basically, again, a double-blinded, randomized trial looking for improvement in symptoms that are typically related to sensitivities, food sensitivities. We were looking at various inflammatory conditions where the control diet was, again, a sham diet where foods were taken out, but they were not ALCAT test positive foods. The test subject didn't know that their new diet instructions were excluding ALCAT test positive foods or ALCAT negative things. Then just looking at the outcomes and some biomarkers, and specifically Serum Amyloid A and body composition. There were differences seen that were pretty distinct between the two groups. There was a much greater improvement in the symptoms in the report, which is also on our website. It was, again, the University of Northern Illinois. Dr Lukaszuk led the research project, showed that there was much greater reduction in symptoms amongst the people who were following the ALCAT test and the significance was significantly high. It wasn't something that could have happened as a function of [inaudible 00:26:01]. There was a very sharp drop in Serum Amyloid A, which a lot of people are beginning to look at more than high-sensitivity C-reactive proteins as an indicator of total body inflammation. It puts together a nice picture of that. Biochemistry is changing. The new system is less reactive and people are improving body composition and reducing their symptoms. Gazella: Yeah. It sounds like you've got some great research going on, but I'd like to talk a little bit about the future. Can you tell us about cellular technology for identification of functional nutritional deficiencies? Deutsch: One of my favorite topics. I used to live in Austin for 14 years. During that time, there was a lab. There was a charitable organization named the Clayton Foundation that backed a researcher of Experimental Biology Department, University of Texas in Austin named William Shive. William Shive was a protégé of a gentleman who wrote the book in the 1950s called Biochemical Individuality. That book basically explained that we're all quite different, and his experience was that he went in. Prior to the 1950s, he went in for a surgery the night before. They gave him morphine to help him sleep, and it kept him awake all night. That kind of reaction caused him to think over about how we're all a little bit different. A paradoxical reaction like that was quite pronounced. He did a lot of research just in animals and humans, looking at how we're different, and extended that concept to the idea that nutritional needs are also unique. In the 1970s, a group basically challenged, recognized that we needed, as a profession, to have a test for nutritional deficiencies that took into account individuality. William Shive was proposed as the person to help develop it because of his knowledge in the field. He got backing from the Clayton Foundation. The Clayton Foundation, by the way, was a gentleman named Clayton who was in partnership with MD Anderson there in New Orleans. They would support research in nutrition and cancer. One of the things they did was to try and recycle the funding. As soon as something was developed, they would try and commercialize and monetize it, license it out, and recycle those funds for new things, because philanthropists want to see more and more benefit happen. I got to know Dr Shive, and he was doing his evaluations in using the classical way of looking at lymphocyte proliferation, using incorporation of radioactive [inaudible 00:29:27] into the DNA and then extracting that after five days and measuring radioactivity and therefore inferring how much new DNA there was, what DNA synthesis levels occurred and being able to infer growth of lymphocytes, which we spoke about before. When they were stimulated by a mitogen, where a mitogen could be a plant lectin like phytohemagglutinin, which would universally induced EMD cells to multiply. Remembering here what I was speaking to you about the difference between gluten sensitivity and celiac disease. Celiac disease is, again, involving T lymphocytes, meaning it's a function of the specific immune system, so only certain T lymphocytes will recognize a pathogen's peptides being presented to it, and others won't, which is why it's not really a great test for looking at particular allergies because there's too much background noise. 99% of lymphocytes don't react to a pathogen, but 1% of them do. After an infection or during an infection, a small number of lymphocytes that recognize the pathogen will divide in the circulation and in the lymphatics and multiply themselves, which is obviously not something that granulocytes to. He's stimulating lymphocytes with a mitogen. You want them to divide, because the ability of these cells to divide and clone rapidly enables you to produce the antibodies and the lymphocytes that will kill the pathogens. What they need to divide are nutrients. If you stimulate them, and they divide very slowly, you might look at adding nutrients into the culture. There was research done on that in the 1930s where people would take mold spores and radiate them and see that they no longer would divide. Then they one by one added back specific nutrients to see what would restore metabolic machinery. In fact, a group from the University of Chicago got a Nobel prize for that in 1958, so the idea was out there that lymphocyte proliferation could be a good marker for measuring a functional response to changing nutrients in a culture. My early discussions with Dr Shive were, "Dr Shive, the concept is great, but why are you using this old-fashioned method that involves radioactivity if you want to count cells?" Use a cell counter. He agreed. We started to do some work together. Unfortunately, Dr. Shive passed away, but I always was fascinated by that area, and continued to work on it for maybe 15 or 20 years, looking at using cell counters to measure lymphocyte response when stimulated with a mitogen when you alter the culture medium to add another nutrient, one by one. If you found that the adding of the nutrient induced a more robust lymphocyte proliferative response, you can infer that for whatever reason functionally, that nutrient was not at optimal levels, and there should be repletion of that nutrient through foods that contain it or even supplementation. After many years, we kind of looked at that, but we thought that even a cell counter, we're in the cell counter manufacturing business. Some people don't know it, but we're a CLIA lab, and we do these tests, but we also build cell counters and sizers that are used in our tests, because we want them to do very specific things. We found that there were other methods that we looked at that could be done more rapidly and more simply, and correlated with the cell counts. We've been validating that over the last couple of years, and we're actually going to release that testing this month, in January, to look at the levels of improvement of specific immune function when you add specific micronutrients to cell cultures. We're also looking at doing the same kind of testing under conditions of oxidative stress to see which antioxidants improve the survival of the cells when there is an oxidative stress situation going on. Gazella: That's awesome. There's a lot of integrative practitioners who are interested in that type of personalized medicine. When you say it's available in January, is it clinically available to practitioners in January? Deutsch: Yes. Gazella: Awesome. That's great. Deutsch: Yeah, we're making it available. Gazella: I have one final question. I've been researching Cell Science Systems, and it seems like it's not just about delivering a test for your company. It's about helping clinicians personalize the diet for their patients, but then providing support regarding compliance and sustainability. Why is that so important to your company? Deutsch: Our company is here to help. I've done this for coming on 34 years now, and I had health problems in my earlier years. I worked through it. I was an athlete as a kid and all that, played on teams and all that, but I had bad allergies. Finally, when I was in my 20s, with the help of some naturopaths in Australia, figured out that my issues were basically diet-driven. I got interested in this field. I know how, from firsthand experience, what a problem it can be if you don't know that you're eating something which causes your eczema, your respiratory problems, your fatigue, your arthritis, your migraines, so on and so forth. I want to do everything possible to have an impact. I know that's the way most people in the naturopathic community are as well. We've created some tools to help educate patients, to help them comply, to help them understand how to substitute certain things, to be able to take an ALCAT test result and have it reflect into a several-hundred-page personalized book of recipes, and then just make this all available. We created an educational course, which actually, we'll have to go to the Naturopathic Societies and see if they'll accredit it, but we have accreditation for this from the dietitians and nurse practitioners, so it's a course that we offer. Again, we're going to present this to the naturopaths. It costs $199. Then when people go through that, then they can purchase from us these meal planning tools and other things for their patients. We're going to put a lot of this online, so it'll be very convenient, at our website for this purpose, called GutHealthPartners.org, and just make compliance a lot easier so people stick with it and get the benefits. That's what we're doing. Gazella: That's great. We also have a lot of dietitian and nurse practitioners who are readers of the Natural Medicine Journal, so I'm sure that they'll appreciate that. That sounds like a wonderful mission for your company. This has been very interesting. Thank you again, Roger, for joining me today. Once again, I'd also like to thank our sponsor, of course, Cell Science Systems. Have a great day, Roger. Deutsch: Thanks. Thanks for having me, Karolyn.

We all get an itchy scalp from time to time, but imagine a burning, painful sensation (similar to a sunburn on your scalp) that never goes away.We all get an itchy scalp from time to time, but imagine a burning, painful sensation (similar to a sunburn on your scalp) that never goes away.It's a condition referred to as burning scalp syndrome.Unfortunately, many doctors have a hard time diagnosing (and thus treating) the condition, leaving sufferers frustrated and at their wits' end. Symptoms include burning, itching, scalp sensitivity, pain when combing/brushing/styling, and may even result in hair loss.Causes of Burning Scalp SyndromeThe number-one cause of burning scalp syndrome is chronic stress, whether from daily stressors or anxiety, depression, and even recovering from an injury. A neuropeptide called Substance P is the culprit. Substance P is the key "first responder" to stresses in your life. When stress becomes chronic, Substance P builds up and becomes too excessive for your body to handle. Aside from burning scalp syndrome, other issues such as restless leg syndrome, digestive woes, vaginal discomfort, hives for no reason, and even conditions such as fibromyalgia can all be caused by excessive amounts of Substance P.Treatment OptionsAfter studying the syndrome, Dr. Ward Bond has come up with certain protocols to address it.Your diet is extremely important. Eat as naturally as possible and stay away from artificial ingredients and bad fats. Good fats have been found to bring relief to some patients, particularly flax oil and borage oil.Magnesium is crucial as well. Low magnesium levels enable excess Substance P to respond. Dr. Bond prefers the Natural Vitality brand Natural Calm and advises to take it in morning and again in the evening.You can also ingest cayenne internally. This tricks the nervous system into thinking an injury has occurred, but triggers the release of excess substance P. Quercetin removes Substance P from the nervous system as well, and is also a natural antihistamine. Acetyl L-Carnitine gets the left and right sides of the brain to communicate more efficiently and also reduces Substance P levels. This improves focus and optimizes release of serotonin and dopamine.Regular exercise and stretching can also be beneficial, as well as focusing on the good in your life.Listen in as Dr. Bond joins hosts Andrea and Lisa to share information on burning scalp syndrome, the other health concerns associated with excess Substance P, and how you can use nutrition to address your symptoms.

This week on the On Your Mind Neuroscience Podcast:   Kat's away, and Liam is reunited with Adel Farah. Long time listeners will remember that a year ago Adel left academia for medschool, and Liam has recently decided that he will be leaving academia for.... something. We have a long chat about our motivations for leaving and what we have found, or hope to find, in the next phases of our careers.    This week Liam is bummed that he doesn't live in the States, because it means he can't sign up for Genes for Good, an academic project that periodically collects health data from you, then sends you a DNA kit and correlates genetic findings with health outcomes. If you ask them they'll also send you the results of your gene profiling, but you'll have to go elsewhere for interpretation.    Adel has been thinking about something similar, but for tumors. A recent commentary in Nature proposed a banking of genetic samples from all tumors, alongside long term patient outcome information. This could help up get a lot more insight into the genetics or cancers that go into remission, or have a high chance of resurfacing.    Finally, our paper this week (OA) deals with the interaction of pain signaling and pain relief signaling by showing that activation of a "pain receptor" (NK1R) can increase the signaling of a pain relief signaling through the mu opioid receptor (MOR) by increasing its recycling to the cell membrane.    NKR signals through Protein Kinase C, and a PKC inhibitor removed the ability of NK1R to incrase MOR recycling while activating PKC independant of NK1R increased recycling. PKC seems to act by phosphorylating sites directly on MOR.    Finally they showed that giving mice Substance P, a terrifyingly named activator of NK1R, helped the opioid Fentanyl maintain it's effectiveness over two doses.    For links to everything we talked about today, full shownotes, and past episodes head to www.onyourmind.ca

Dr. Dwight Jennings is a dentist and TMJ Specialist with expertise in treating orofacial pain, non-surgical orthodontics, and dental orthopedics. Dwight has been practicing neuromuscular dentistry for over 25 years, and has been involved in clinical research and creating new therapies for a large number of medical and developmental disorders that are associated with TMJ, jaw/bite misalignment, and high levels of systemic inflammation caused by the pain neurotransmitter, substance P.   Why you should listen –     Dr. Dwight comes on Bulletproof Radio to discuss how bite alignment impacts the rest of the body, why jaw pain is a systemic functional health disorder, the difference between orthodontics and dental orthopedics and how to find a specialist that can properly help you with TMJ, and how you can upgrade overall physical performance by adjusting your bite and jaw alignment. Enjoy the show!

Dr. Dwight Jennings is a dentist and TMJ Specialist with expertise in treating orofacial pain, non-surgical orthodontics, and dental orthopedics. Dwight has been practicing neuromuscular dentistry for over 25 years, and has been involved in clinical research and creating new therapies for a large number of medical and developmental disorders that are associated with TMJ, jaw/bite misalignment, and high levels of systemic inflammation caused by the pain neurotransmitter, substance P.   Why you should listen –     Dr. Dwight comes on Bulletproof Radio to discuss how bite alignment impacts the rest of the body, why jaw pain is a systemic functional health disorder, the difference between orthodontics and dental orthopedics and how to find a specialist that can properly help you with TMJ, and how you can upgrade overall physical performance by adjusting your bite and jaw alignment. Enjoy the show!

Commentary by Dr. Valentin Fuster

ELECTRICAL stimulation of presynaptic fibres to the so-called AH1 or type II2 myenteric neurones in guinea pig small intestine evokes a slow excitatory postsynaptic potential (e.p.s.p.) characterised by long-lasting depolarisation associated with increased membrane resistance and augmented excitability3. Two substances have been implicated as possible neurotrans-mitters for the slow e.p.s.p. Katayama and North reported that application of substance P to myenteric neurones mimicked the slow e.p.s.p.4, and J.D.W. and C.J.M. presented several lines of evidence for serotonin as the transmitter substance5,6. We now report that methysergide, a drug which abolishes both the slow e.p.s.p. and the action of exogenous serotonin5,6, does not affect the action of substance P on guinea pig myenteric neurones. The results suggest that substance P is unlikely to be the neuro-transmitter which mediates the slow e.p.s.p.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.22.056119v1?rss=1 Authors: Moya-Diaz, J., James, B., Lagnado, L. Abstract: Multivesicular release (MVR) allows retinal bipolar cells to transmit visual signals as changes in both the rate and amplitude of synaptic events. How do neuromodulators reguate this vesicle code? By imaging larval zebrafish, we find that the variability of calcium influx is a major source of synaptic noise. Dopamine increases synaptic gain up to 15-fold while Substance P reduces it 7-fold, both by acting on the presynaptic calcium transient to alter the distribution of amplitudes of multivesicular events. An increase in gain is accompanied by a decrease in the temporal precision of transmission and a reduction in the efficiency with which vesicles transfer visual information. The decrease in gain caused by Substance P was also associated with a shift in temporal filtering from band-pass to low-pass. This study demonstrates how neuromodulators act on the synaptic transformation of the visual signal to alter the way information is coded with vesicles. Copy rights belong to original authors. Visit the link for more info