Podcasts about inflammatory response

In this episode of the Tick Boot Camp podcast, we have the privilege of hearing from Dr. James Neuenschwander, an integrative medicine and emergency medicine physician. Dr. Neuenschwander discusses his extensive experience in treating chronic illnesses in children, with a special focus on those on the autism spectrum. With over 35 years of experience, Dr. Neuenschwander is also the president of the Medical Academy of Pediatric Special Needs (MAPS). Key Takeaways: Defining Chronic Illness in Children: Chronic conditions in children, such as asthma, autism, and PANS/PANDAS, often persist for more than a month or two and can significantly affect their quality of life. Immune System Differences: While children generally have a more robust innate immune system, they are more vulnerable to Lyme infections and neurological complications due to their porous blood-brain barrier. Inflammatory Response and Brain Inflammation: Although children may not show severe inflammatory responses to tick bites, brain inflammation can lead to developmental regression and psychiatric symptoms, further complicating diagnosis and treatment. Co-Infections and Diagnostic Challenges: Co-infections such as Borrelia, Babesia, and Bartonella are common in pediatric chronic illnesses, making diagnosis more complex and requiring an integrated approach to treatment. Environmental Factors and Autism: Infections, toxins, and immune system activation are factors that can induce brain inflammation and increase the risk of autism, contributing to the rising prevalence of autism spectrum disorders. Importance of Integrative and Holistic Approaches: Dr. Neuenschwander emphasizes the need to address the whole ecosystem in treating children with chronic illnesses, focusing on gut health, nutrition, environmental factors, and immune system balance, rather than just targeting specific infections. Role of MAPS in Training Practitioners: The Medical Academy of Pediatric Special Needs (MAPS) plays a vital role in educating healthcare providers on integrative techniques for managing complex chronic conditions in children. Resources & Links: Follow the latest ILADS updates at ILADS.org Learn more about Dr. James Neuenschwander here Stay connected with Tick Boot Camp: Website | Instagram | Facebook | YouTube | TikTok | Twitter (X)

Dr. Darin Ingels presents a comprehensive 5-part plan to combat Lyme disease. Learn how to address the inflammatory autoimmune response and achieve better health through naturopathic solutions. #LymeDisease #AutoimmuneHealth #NaturopathicCare

Dr. Darin Ingels presents a comprehensive 5-part plan to combat Lyme disease. Learn how to address the inflammatory autoimmune response and achieve better health through naturopathic solutions. #LymeDisease #AutoimmuneHealth #NaturopathicCare

Dr. Darin Ingels presents a comprehensive 5-part plan to combat Lyme disease. Learn how to address the inflammatory autoimmune response and achieve better health through naturopathic solutions. #LymeDisease #AutoimmuneHealth #NaturopathicCare

Commemorating 38th year of Intelligent Medicine; A pricey prostate drug advertised on football games may extend life for mere months without promise of cure; You dutifully threw out your “toxic” black plastic spatulas—was it faulty math? Air pollution robs marathoners of record times—and may be responsible for deaths of millions; Indian man, declared dead, taken to hospital after awakening on funeral pyre. 

John Dick, Ph.D., F.R.S., explores the role of CD83, a molecule found in blood stem cells, in how these cells respond to inflammation. His team demonstrates that CD83 becomes highly active during inflammation and contributes to the loss of healthy stem cells. Using advanced gene-editing tools, they show that removing CD83 protects stem cells from inflammation-related damage. This discovery highlights CD83 as a potential marker for identifying inflamed stem cells and as a possible target for treatments to improve recovery after stem cell transplants. He also discusses early findings on potential differences in blood stem cell behavior between men and women and raises questions about how inflammation from severe illnesses, like COVID-19, could impact the blood system as we age. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39949]

John Dick, Ph.D., F.R.S., explores the role of CD83, a molecule found in blood stem cells, in how these cells respond to inflammation. His team demonstrates that CD83 becomes highly active during inflammation and contributes to the loss of healthy stem cells. Using advanced gene-editing tools, they show that removing CD83 protects stem cells from inflammation-related damage. This discovery highlights CD83 as a potential marker for identifying inflamed stem cells and as a possible target for treatments to improve recovery after stem cell transplants. He also discusses early findings on potential differences in blood stem cell behavior between men and women and raises questions about how inflammation from severe illnesses, like COVID-19, could impact the blood system as we age. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39949]

John Dick, Ph.D., F.R.S., explores the role of CD83, a molecule found in blood stem cells, in how these cells respond to inflammation. His team demonstrates that CD83 becomes highly active during inflammation and contributes to the loss of healthy stem cells. Using advanced gene-editing tools, they show that removing CD83 protects stem cells from inflammation-related damage. This discovery highlights CD83 as a potential marker for identifying inflamed stem cells and as a possible target for treatments to improve recovery after stem cell transplants. He also discusses early findings on potential differences in blood stem cell behavior between men and women and raises questions about how inflammation from severe illnesses, like COVID-19, could impact the blood system as we age. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39949]

John Dick, Ph.D., F.R.S., explores the role of CD83, a molecule found in blood stem cells, in how these cells respond to inflammation. His team demonstrates that CD83 becomes highly active during inflammation and contributes to the loss of healthy stem cells. Using advanced gene-editing tools, they show that removing CD83 protects stem cells from inflammation-related damage. This discovery highlights CD83 as a potential marker for identifying inflamed stem cells and as a possible target for treatments to improve recovery after stem cell transplants. He also discusses early findings on potential differences in blood stem cell behavior between men and women and raises questions about how inflammation from severe illnesses, like COVID-19, could impact the blood system as we age. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39949]

John Dick, Ph.D., F.R.S., explores the role of CD83, a molecule found in blood stem cells, in how these cells respond to inflammation. His team demonstrates that CD83 becomes highly active during inflammation and contributes to the loss of healthy stem cells. Using advanced gene-editing tools, they show that removing CD83 protects stem cells from inflammation-related damage. This discovery highlights CD83 as a potential marker for identifying inflamed stem cells and as a possible target for treatments to improve recovery after stem cell transplants. He also discusses early findings on potential differences in blood stem cell behavior between men and women and raises questions about how inflammation from severe illnesses, like COVID-19, could impact the blood system as we age. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39949]

John Dick, Ph.D., F.R.S., explores the role of CD83, a molecule found in blood stem cells, in how these cells respond to inflammation. His team demonstrates that CD83 becomes highly active during inflammation and contributes to the loss of healthy stem cells. Using advanced gene-editing tools, they show that removing CD83 protects stem cells from inflammation-related damage. This discovery highlights CD83 as a potential marker for identifying inflamed stem cells and as a possible target for treatments to improve recovery after stem cell transplants. He also discusses early findings on potential differences in blood stem cell behavior between men and women and raises questions about how inflammation from severe illnesses, like COVID-19, could impact the blood system as we age. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39949]

Emily Watkins - Researcher & Technical Instructor at the University of Brighton The conversation explores the value of academia in the first responder community and the consequences of chronic high exposure firefighting. The discussion focuses on the research conducted by Emily Watkins, a senior lecturer at the University of Roehampton, on the health and wellbeing of firefighters. The conversation delves into the challenges of funding research in this field and the reluctance to address the long-term implications of occupational exposure. The World Health Organization's declaration on firefighting as a carcinogenic occupation is also discussed, along with the need for evidence-backed preventative measures. The study conducted by Watkins examines the inflammatory and immune responses of breathing and operating instructors (BAIs) in the firefighting profession. The findings suggest that BAIs may experience chronic inflammation due to their high frequency of exposures. The study also explores the physiological and psychological effects of firefighting workloads on BAIs and firefighters. The conversation covered various topics related to the health and well-being of firefighters, including mood states, fatigue, biomarkers, cardiovascular disease, and the World Health Organization's research on firefighter health. The discussion highlighted the need for comprehensive testing and screening for firefighters, as well as the importance of self-care and early support. The conversation also touched on the challenges faced by female firefighters and the need for research and support specific to their unique physiological differences.You can connect with Emily at - Emily.Watkins@roehampton.ac.ukWe only feature the latest 200 episodes of the podcast on public platforms so to access our podcast LIBRARY, every Debrief & document CLICK HEREPODCAST GIFT - Get your FREE subscription to essential Firefighting publications HERE A big thanks to our partners for supporting this episode.GORE-TEX Professional ClothingMSA The Safety CompanyPATROL STORE UKIDEXHAIX FootwearGRENADERIP INTO Podcast ApparelLyfe Linez -  Get Functional Hydration FUEL for FIREFIGHTERS, Clean no sugar  for daily hydration. 80% of people live dehydrated and  for firefighters this costHibern8 - a plant based sleep aid specially designed to promote a restful night's sleep and awaken you feeling refreshed and energisedPlease support the podcast and its future by clicking HERE and joining our Patreon Crew

References Cells 2020, 9(1), 228 Front. Immunol. 2020. vol 11. 29 November. FEBS 2013. Volume280, Issue15 August:3530-3541 Cell Metabolism 2016. 23, 1127–1139 Beethoven. LV . 1800. Septett Es-Dur op. 20 https://youtu.be/pXsj43qCcUA?si=r5vW4PpfzvywF9b3  Jacques Revaux  Gilles Thibaut and Claude François 1967. "My Way". Sinatra https://youtu.be/qQzdAsjWGPg?si=YWKurvGp9Xt0TYK1 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

It's hard for many to believe a tick bite or case of COVID can lead to severe mental illness, but we'll be hearing from someone on this episode of Raise the Line who lived through just that experience. Dr. Raven Baxter also happens to be the host of this special series on post-acute infection syndromes produced in collaboration with the Cohen Center for Recovery from Complex Chronic Illnesses at Mt. Sinai. While struggling with long COVID, Raven developed panic attacks and other mental health problems, and even though she explained to providers that she previously had no history of mental illness, there was reluctance to attribute the symptoms to her body's reaction to SARS‑CoV‑2. Unfortunately, this is not surprising to Dr. Shannon Delaney, a psychiatrist whose patients share similar stories. “People who are going through this can be suffering a lot, not only because of their symptoms, but because of invalidation from the medical community,” says Delaney, who believes brain inflammation caused by immune system dysregulation can explain why mental health issues emerge in this context. While Raven's other guest, Dr. Mike VanElzakker, concurs, his research at Massachusetts General Hospital and the PolyBio Research Foundation focuses on the vagus nerve as a contributing factor to symptoms of various types. “I would argue at least part of what people with these complex chronic illnesses are experiencing is an ongoing sickness response and that may be because there is a signal that's constantly bombarding the vagus nerve, which may be sensitized by inflammation.” This is an eye-opening look at mind-body connections that are challenging conventional wisdom.  Mentioned in this episode:Mount Sinai Health System Steven & Alexandra Cohen Foundation 

In this episode we discuss how certain foods can trigger and inflammation response in the body.  As it is best to avoid these foods as much as possible.Our website: https://acupunctureismylife.com/Follow our social media for more information on acupuncture:Instagram: https://www.instagram.com/acupunctureismylife/Facebook: https://www.facebook.com/acupunctureismylifeTikTok: https://www.tiktok.com/@acupunctureismylife?lang=e

Dr. Joel Fuhrman emphasizes the importance of a diet rich in green vegetables for maintaining the integrity of the digestive lining, supporting a healthy immune system, and reducing the risk of diseases, including cancer. According to him, our body's health, especially the gut's health, is significantly influenced by our eating habits. Consuming a high amount of salt, oil, and sugar disrupts the digestive tract and increases the risk of autoimmune diseases. In contrast, green vegetables foster the growth of a healthy gut and are vital for a robust immune system. This, in turn, plays a role in our response to infections and our overall health outcomes. #GutHealth #GreenVeggies #ImmuneBoost

Dr. Penner describes two primary factors of gut health to be absorption and barrier function or permeability. His lab's work on permeability is suggesting that intestinal regions really drive total gut permeability to a much greater extent than ruminal permeability in dairy cows. (7:06)Ms. Bertens is Dr. Penner's Ph.D. student and explains some new methodologies she developed for measuring gut permeability using chromium EDTA and cobalt EDTA. It's common to use an oral dose of chromium EDTA as a marker to measure total tract permeability. Claire's work, using cannulated cows, used a ruminal dose of chromium EDTA for total tract permeability and an abomasal dose of cobalt EDTA for post-ruminal permeability. Both of these markers are indigestible, non-metabolizable and have no transcellular transport mechanisms. Claire is working to publish the new method as a complete validation study has been completed. (9:15)While this method is currently limited to using cannulated animals, Greg and Claire could envision a less sophisticated and more applied on-farm technique to assess permeability. Until then, there are still a lot of management observations that can identify potential issues with gut permeability. The appearance of feces and the presence of mucin casts can both be indicative of gut issues. Certainly dry matter intake is a major influencer on gut health, and Claire also sees potential in new technologies like rumination collars or rumination ear tags. (13:47)Are there certain time points in a dairy cow's life when she is at risk for increased gut permeability? Dr. Penner describes research suggesting if weaning is implemented too abruptly, that really increases the risk for decreased barrier function of the gut. Erratic feed intake patterns resulting from withholding feed for any reason at any age can also increase the risk of leaky gut. For example, depressed intake during the transition phase, along with anything that drives a response through an underlying systemic inflammatory response, probably creates risky situations for leaky gut. Claire is currently running a study looking at the impacts of intramammary LPS infusion on gut function. Greg envisions that learning more about gut function could create a new philosophy for treating sick animals. In the past, only antimicrobials were used to treat mastitis, but now it's common to also treat with a NSAID for pain. Perhaps in the future, we will also provide treatment to accelerate the recovery of the gut to prevent secondary disorders. (16:15)How long does an off-feed event have to last to cause an issue in the gut? It seems a fairly acute time period is all that is needed. Most studies are trying to replicate what happens on-farm, for example during mastitis, heat stress or the transition period. Greg indicates that not only will permeability be impacted, but ruminal absorptive capacity can also decline rapidly in these conditions. In Claire's LPS challenge study, cows' rectal temperatures peak around six hours after the LPS infusion and usually resolve within 12 hours. But most cows do not eat for a solid 12 hours during the challenge, and they are slow to recover feed intake over the next few days. In cows that aren't sick but experience feed restriction in experimental protocols, they tend to overeat when they are allotted the full ration and this can lead to ruminal acidosis. (21:57)Increased incidences of liver abscesses in beef-on-dairy calves are being reported in the industry. Dr. Penner speculates that perhaps these calves are not always achieving adequate passive transfer, and may not be receiving high enough levels of milk replacer to support a more robust immune system. It may be the increased beef cattle genetics in the calves are putting an added requirement on growth or muscle development that may not be met by lower levels of milk replacer or even lower colostrum feeding levels. (34:40)In closing, providing cows with a consistent environment where they can meet their needs by their own behavior such as free access to feed when hungry and to a comfortable stall when it's time to rest. Cows reward consistency with health and production. Gut health in a commercial setting is a relevant issue and it might go undiagnosed or undetected. Research into where in the gut permeability is occurring will help define strategies to modulate response. While off-feed events for individual animals might be harder to recognize in a large dairy environment, new technology may allow for earlier diagnosis. (40:43)Please subscribe and share with your industry friends to bring more people to join us around the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll get a shirt in the mail to you.

Her film My Octopus Teacher won an academy award -- and her insights on nature, and her love for it, go far beyond the film. Pippa Ehrlich joins Vasant Dhar in episode 77 of Brave New World to talk about her work and what she has learnt from it. Useful resources: 1. Pippa Ehrich on Instagram, X, LinkedIn and IMDb.. 2. My Octopus Teacher -- Pippa Ehrlich and James Reed. 3. Peter Singer on Animal Liberation -- Episode 74 of Brave New World. 4. Save Our Seas Foundation. 5. 20,000 Leagues Under the Sea -- Jules Verne. 6. Using Deliberate Cold Exposure for Health and Performance -- The Huberman Lab Podcast. 7. Wim Hof Method. 8. The Effects of Cold Exposure Training and a Breathing Exercise on the Inflammatory Response in Humans: A Pilot Study -- Jelie Zwaag et al. 9. Dmitry Rinberg on the Mysteries of Smell -- Episode 62 of Brave New World. 10. Anthony Zador on How our Brains Work -- Episode 35 of Brave New World. 11. Deep Rising --  Matthieu Rytz. 12. David Chalmers on the Nature of Reality -- Episode 41 of Brave New World. 13. Sea Change Project. Check out Vasant Dhar's newsletter on Substack. Subscription is free!

References Luigi Boccherini: Symphony Op. 12 No. 4 in D Minor JCI Insight. 2016 Nov 17; 1(19): e87748 Front Immunol. 2023; 14: 1149366 Adv Biol Regul.2019 Jan;71:41-54. Int. J. Mol. Sci. 2019, 20(6), 1505 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

Pour accéder à l'intégralité de ce podcast et écouter chaque semaine un nouvel épisode du Quart d'Heure Véto, c'est très simple, il vous suffit de vous abonner en cliquant sur ce lien : https://m.audiomeans.fr/s/S-yUNSBZSR L'équipe de Claudia Giannetto s'est intéressée à la réponse immunitaire et inflammatoire qui découle d'une vaccination contre la rhinopneumonie, une affection virale pouvant entrainer des épidémies souvent catastrophiques dans la population équine. Notes et références Article C. Giannetto and all; Immune and Inflammatory Response in Horse Vaccinated Against Equine Herpesviruses 1 (EHV-1) and 4 (EHV-4) Assessed by Serum Protein Electrophoretic Pattern and Leukocyte Population - Journal of Equine Veterinary Science. 2022 Sept:Vol. 116. Pour acheter et télécharger l'article : https://doi.org/10.1016/j.jevs.2022.104051 Retrouvez toute la synthèse sur la fiche podcast : https://audmns.com/AbhZlkj Pour nous suivre : 1. Abonnez-vous à notre chaine pour profiter de l'intégralité des épisodes : Le Quart d'Heure Véto : décrypte et résume en moins de 15 min un article de biblio véto - Sur abonnement uniquement Le Véto du Mois : Partagez le temps d'une interview l'expérience de vétérinaires emblématiques de notre milieu, des rencontres conviviales, comme si nous étions dans votre salon au coin du feu. Podcasts bonus au fil des inspirations... 2. Le Scope Nous partageons avec vous nos dernières découvertes, inspirations, pistes de réflexion, nouveautés… À découvrir et utiliser dès maintenant, TOUT DE SUITE, dans votre quotidien de vétérinaire, de manager, de vie personnelle, de chef d'entreprise… Et tout cela en moins de 5 minutes top chrono un à 2 mardis par mois ! Je souhaite recevoir mon Scope : https://vetmasterclass.com/lescope/ 3. Contactez-nous, suivez-nous et donnez nous votre avis ! Des sujets que vous souhaiteriez approfondir, des références à partager, ou nous faire part de vos feed-backs : Abonnez-vous à notre chaine, donnez nous des étoiles, un commentaire et partagez autour de vous ! Sur notre site : https://vetmasterclass.com/ Sur Facebook : https://www.facebook.com/VmHorse Sur Instagram : https://www.instagram.com/vetmasterclass/ Sur YouTube : https://www.youtube.com/channel/UC18ovcWk9e-mFiTL34OQ03g Sur Linkedin : https://www.linkedin.com/company/vetmasterclass-horse/about/ Belle journée à tous, Et continuez à vivre votre métier avec Passion !

References Guerra general graduate biochemistry lectureImmunol Res. 2020 Feb;68(1):28-38. doi: 10.1007/s12026-020-09125-9. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message

References Guerra's notes --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.06.527402v1?rss=1 Authors: Yu, B. Abstract: Objective: To facilitate in vitro mechanistic studies in pelvic inflammatory disease (PID) and subsequent tubal factor infertility, as well as ovarian carcinogenesis, we sought to establish patient tissue derived fallopian tube (FT) organoids and to study their inflammatory response to acute vaginal bacterial infection. Design: Experimental study. Setting: Academic medical and research center. Patients: FT tissues were obtained from four patients after salpingectomy for benign gynecological diseases. Interventions: We introduced acute infection in the FT organoid culture system by inoculating the organoid culture media with two common vaginal bacterial species, Lactobacillus crispatus and Fannyhessea vaginae. Main Outcome Measures: The inflammatory response elicited in the organoids after acute bacterial infection was analyzed by the expression profile of 249 inflammatory genes. Results: Compared to the negative controls that were not cultured with any bacteria, the organoids cultured with either bacterial species showed multiple differentially expressed inflammatory genes. Marked differences were noted between the Lactobacillus crispatus infected organoids and those infected by Fannyhessea vaginae. Genes from the C-X-C motif chemokine ligand (CXCL) family were highly upregulated in F. vaginae infected organoids. Flow cytometry showed that immune cells quickly disappeared during the organoid culture, indicating the inflammatory response observed with bacterial culture was generated by the epithelial cells in the organoids. Conclusion: Patient tissue derived FT organoids respond to acute bacterial infection with upregulation of inflammatory genes specific to different vaginal bacterial species. FT organoids is a useful model system to study the host-pathogen interaction during bacterial infection which may facilitate mechanistic investigations in PID and its contribution to tubal factor infertility and ovarian carcinogensis. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.17.512513v1?rss=1 Authors: Jiang, Y., He, Y., Liu, S., Li, G., Chen, D., Deng, W., Li, P., Zhang, Y., Wu, J., Li, J., Wang, L., Lin, J., Wang, H., Kong, S., Shi, G. Abstract: Decidualization, denoting the transformation of endometrial stromal cells into specialized decidual cells, is a prerequisite for normal embryo implantation and a successful pregnancy in human. Here we demonstrated that knockout of Gaq lead to an aberrantly enhanced inflammatory state during decidualization. Furthermore, we showed that deficiency of Gaq resulted in over-activation of nuclear factor (NF)-{kappa}B signaling, due to the decreased expression of NF{kappa}BIA, which encode the I{kappa}B protein and is the negative regulator for NF{kappa}B. Mechanistically, Gaq deficiency decreased the PKD/PKC phosphorylation levels, so leading to attenuated HDAC5 phosphorylation and thus its nuclear export. Aberrantly high level of nuclear HADC5 retarded histone acetylation to inhibit NF{kappa}BIA transcription during decidualization. Consistently, pharmacological activation of the PKD/PKC or inhibition of the HDAC5 signaling restored the inflammatory state and proper decidual response. Finally, we disclosed that over-active inflammatory state in Gaq deficient decidua deferred the blastocyst hatching and adhesion in vitro, and the decidual expression of Gq was significantly lower in women with recurrent pregnancy loss compared with normal pregnancy. In brief, we showed here that Gq as a key regulator of the inflammatory cytokine's expression and decidual homeostasis in response to differentiation cues, which is required for successful implantation and early pregnancy. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

CF 235: The Inflammatory Response's Effect On Chronic Pain & The Entry Point For Low Back Pain Today we're going to talk about the inflammatory response's protection from chronic pain, which is fascinating.. and we'll talk about where patients should be starting their journey for low back pain.  But first, here's that sweet sweet bumper... The post The Inflammatory Response's Effect On Chronic Pain & The Entry Point For Low Back Pain appeared first on Chiropractic Forward.

Show Summary: "Healing is a marathon, not a sprint."Do you know someone who has autoimmune diseases? There are about 110 types of autoimmune diseases, and most people who have them are not aware that they have them. Checking your food intake and what foods you should avoid eating can help you heal these diseases.We have Dr. Donna Mazolla, a.k.a Dr. Autoimmune Girl, to discuss elimination diets and autoimmune diseases with us for this episode. For someone who has had Hashimotos for several years, Donna is the perfect person who can tell us what works and what does not work with the food we eat. Plus, she is a doctor of pharmacology! She shares all she knows through her book "Immunity Food Fix." Donna teaches people what she has been practicing. Like us, she realized that there is a gap in health care that other medical professionals do not address that much - nutrition and lifestyle. Instead, they prescribe medication and let their patients go about their way without being adequately advised or educated about what they should eat or avoid. So please tune in to this episode and share it with as many people as possible to be your healing champion by simply addressing your nutrition and making the necessary lifestyle changes. If we could do it, you can do it, too! We are here for you. Exceptional Highlights: No wonder people are so traumatized by food because all these quote-unquote experts are all yelling at each other, saying each other is wrong.There is a science to back up that food will make or break you.We need to figure out which buttons to push and which foods to eat to help our bodies heal themselves.Show Highlights: Can you add something about the effects of antibiotics on our microbiome?Donna 13:33It's impacted our immune system; it's decreased our oral tolerance. We see a rise in allergies as a result.Suppose people are starting to incorporate food after an elimination diet. What are the effects that they should look out for?Donna 18:38It could be fatigue, something you're not even thinking about. But like your typical bloating, diarrhea, or gas, these let you know something is going on with the gut. What about these people that can't even handle vegetables?Donna 21:10For those people, the question is, have you removed all inflammatory foods first? And now you're eating vegetables and can't tolerate it. We have to give it time. Can we get your opinions on the different types of elimination diets?Donna 32:50I am a pro vegetable and not vegan or vegetarian. I'm not anti-animal protein. But I recognize the need, like the phytochemicals present in plants. Looking at Keto and being a carnivore, I'm against these diets because of the disruption and the gut microbiome. Important Links:The Gutsy Health Podcast IGDr. Donna Mazzola's IGSpore-based Probiotics Episode with Dr. Kiran KrishnanHeadaches and Migraines Episode with Dr. Meg MillDr. Donna Mazzola's WebsiteImmunity Food Fix Book

What is the best way to explain immune disease, trauma, free energy, mindfulness and meditation, as well as why it is so common yet so poorly understood... Right under our noses if you will...

References Dr. Guerra lecture notes Prog Neurobiol. 2018 Apr-May; 163-164: 27–58. Arteriosclerosis, Thrombosis, and Vascular Biology. 2006;26:28–40 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

Why are T cells so vital to our immune response? As one of the primary markers of a potential issue, a problem with your T cells could spell disaster. Listen up to learn: The function of a T cell What T cells recognize How T cell exhaustion can be reversed Offer:Want a safe energy-boosting alternative to caffeine? Want to lower free radical damage so you can enjoy optimal cognition, faster muscle recovery, and exceptional wellness? Take the 30-day hydrogen challenge. Drink 2 glasses of hydrogen water daily for 30 days to zap the most damaging free radicals and unleash your inner energy.To get started, use code genius to save 20% on your first order from TryVitalReaction.com John Wherry, the Chair of the Department of Systems Pharmacology at the University of Pennsylvania, shares his research in epigenetics and the vital role of T cells in our immune system. T cell differentiation is an essential process in our body, initially being able to control infection and limit tumor growth. However, if the process reaches T cell exhaustion, it can cause a variety of problems in our immune response. While T cell exhaustion is similar to viruses and tumors, the response can be varied, even if slightly. Still, the reversal of T cell exhaustion has been shown to be effective and will only become more comprehensive as research progresses. Visit https://www.med.upenn.edu/wherrylab/ for more information. Episode also available on Apple Podcasts: http://apple.co/30PvU9C

Chapter 6:Systemic Inflammatory Response Syndrome to Small Animal Critical Care Medicine, 2e 2nd Edition by Deborah Silverstein DVM DACVECC, Kate Hopper BVSc MVSc DACVECC Host: Dr. Bobbi Conner Producer: Topher Conlan

It was surprising to me that the amount of inflammation in our bodies (that we may not even be aware of) can keep us from well-being and using our voice.You'r listening to YOUR Mental Wellness podcast for YOUR voice and sanity. Thank you for joining us this week on your mental wellness podcast for your voice and sanity. Make sure to check out our show notes, visit our website, www dot tools for vitality.com where you can subscribe to the show. We would appreciate it if you would tell a friend about the podcast

HOUR 2 Top 6 Anti-Inflammatory Nutrients – Carolyn Dean MD ND  In medical school we learned about inflammation but not that it is a major cause of chronic disease. I've been saying this for years and now allopathic medicine is agreeing. An April, 2020 Medical News Today article says that inflammation contributes to the following chronic illnesses: metabolic syndrome, which includes type 2 diabetes, heart disease, and obesity.   If you Google my name and inflammation you'll access a whole screen-full of blogs like “Excess Calcium Fuels Neuro-Inflammation.” “Magnesium The Safe and Natural Anti-inflammatory” In my book, The Magnesium Miracle, I mention inflammation 93 times. I've also warned that drug companies are constantly looking for “safe” anti-inflammatory drugs. They struck out with the NSAIDs (nonsteroidal anti-inflammatory drugs) because they cause so many side effects – the worst of which is heart disease. But the deeper reason that many drugs have serious side effects is that they can cause magnesium deficiency – and therefore inflammation!  In addition to the essential role of magnesium, consider the role of the omega's, vitamin A and E as well as zinc and vitamin D. And then consider, again, my recommendations for achieving the RDI's [Recommended Daily Intake] for each of these anti-inflammatory co-factors through diet and supplementation with my Completement Formulas:  Magnesium  A breakthrough study from 2006 entitled Magnesium and the Inflammatory Response shows that at the cellular level, magnesium reduces inflammation. In the animal model used, magnesium deficiency is created when an inflammatory condition is produced. Increasing magnesium intake decreases inflammation.  In a more recent study [June 2017], therapeutic levels of magnesium supplementation are shown to have a positive anti-inflammatory effect in the body.  With magnesium being actively required by 1,000 enzyme systems in the human body, internal functions that reduce inflammation with the help of magnesium are being newly discovered every year. For example, magnesium has been found to be a natural calcium channel blocker, which is crucial because calcium in excess is one of the most pro-inflammatory substances in the body.  This is why I  recommend a 1:1 balance of calcium with magnesium, while also taking into account the amount of calcium people get in their daily diets.  Zinc  In addition to magnesium, zinc plays a critical role in controlling the inflammatory response. A study from researchers at Oregon State University has found that improving zinc status through diet and supplementation may reduce the risk of inflammatory diseases. It has been known for decades that zinc has a significant role in immune function and zinc deficiency has been linked to increased inflammation in chronic disease and triggering new inflammatory processes.  Omega Algae A+E  One of the tremendous benefits of saturation with essential fatty acids is lowering inflammation. They are both important fatty acid components of cell membranes that contribute to the structure, fluidity, flexibility, enzymatic activity, and signaling between cells. Vitamin A is one of the most common vitamin deficiencies in the world and also has a role as an anti-inflammatory agent. and vitamin E is a potent antioxidant with anti-inflammatory properties.  When used properly, the omega's along with vitamin A and E help reduce inflammation and improved the immune response. They increase the activation of macrophages, neutrophils, and dendritic cells (the first-responders that help identify pathogen or virus in the case of an infection), T-cells (that destroy the pathogen or virus), and B-cells (to remember the pathogen or virus and act immediately to destroy it in the case of a future infection), among others.  Vitamin D3  Beyond its critical function in calcium homeostasis, vitamin D has recently been found to play an important role in the modulation of the immune/inflammation system via regulating the production of inflammatory cytokines and inhibiting the proliferation of pro-inflammatory cells.  Lifestyle Choices  Lifestyle choices play a significant role in an individual's susceptibility toward chronic inflammation as well. Dr. Dean points out, “Chronic, low-grade inflammation—sustained by excessive belly fat, a poor diet including processed foods and sugars, lack of exercise, smoking, and gum disease—may explain why lifestyle-related diseases have reached epidemic proportions in Western countries while remaining relatively scarce in the developing world.”  Incorporating nutrients is a choice one can make to prevent heart disease, diabetes, and metabolic syndrome which makes knowing about these nutrients vitally important.  Tonight on our LIVE podcast on YouTube, we'll be talking with Dr. Carolyn Dean about her recommendations for controlling inflammation along with a wide range of health topics and safe solutions. You will love hearing the beneficial interactions with our callers and hosts alike including the body/mind connection, identifying the ‘conflict' in the ‘conflict basis' of disease, and much more!!  About Dr. Carolyn Dean    Dr. Carolyn Dean MD ND has been featured on national media for over 30 years offering practical strategies to improve health, vitality, and well-being the natural way. As a medical doctor, naturopath, certified clinical nutritionist and master of many modalities including acupuncture and homeopathy, Dr. Carolyn Dean MD ND has authored over 33 books and 100 publications including The Magnesium Miracle, 3rd Edition, Hormone Balance, Future Health Now Encyclopedia and Heart Health. Please note that the information and opinions expressed on these broadcasts are not designed to constitute advice or recommendations as to any disease, ailment, or physical condition. You should not act or rely upon any information contained in these broadcasts without seeking the advice of your personal physician. If you have any questions about the information or opinions expressed during these broadcasts, please contact your doctor.  Video Version:  https://youtu.be/gFDgbRB1BbA Disclosure: Dr. Dean does have a financial interest in the sale of all the Completement Formulas.  Call in and Chat with Dr. Dean during Live Show with Video Stream: Call 646-558-8656   ID: 8836953587 press #.  To Ask a Question press *9 to raise your hand  Dr. Dean takes questions via email. Please write questions@drcarolyndeanlive.com We will be glad to respond to your email  Learn more about Dr. Carolyn here: https://drcarolyndeanlive.com   Chatline on Station: http://bit.ly/Dreamvisions7Radio_Network

HOUR 1 Top 6 Anti-Inflammatory Nutrients – Carolyn Dean MD ND  In medical school we learned about inflammation but not that it is a major cause of chronic disease. I've been saying this for years and now allopathic medicine is agreeing. An April, 2020 Medical News Today article says that inflammation contributes to the following chronic illnesses: metabolic syndrome, which includes type 2 diabetes, heart disease, and obesity.   If you Google my name and inflammation you'll access a whole screen-full of blogs like “Excess Calcium Fuels Neuro-Inflammation.” “Magnesium The Safe and Natural Anti-inflammatory” In my book, The Magnesium Miracle, I mention inflammation 93 times. I've also warned that drug companies are constantly looking for “safe” anti-inflammatory drugs. They struck out with the NSAIDs (nonsteroidal anti-inflammatory drugs) because they cause so many side effects – the worst of which is heart disease. But the deeper reason that many drugs have serious side effects is that they can cause magnesium deficiency – and therefore inflammation!  In addition to the essential role of magnesium, consider the role of the omega's, vitamin A and E as well as zinc and vitamin D. And then consider, again, my recommendations for achieving the RDI's [Recommended Daily Intake] for each of these anti-inflammatory co-factors through diet and supplementation with my Completement Formulas:  Magnesium  A breakthrough study from 2006 entitled Magnesium and the Inflammatory Response shows that at the cellular level, magnesium reduces inflammation. In the animal model used, magnesium deficiency is created when an inflammatory condition is produced. Increasing magnesium intake decreases inflammation.  In a more recent study [June 2017], therapeutic levels of magnesium supplementation are shown to have a positive anti-inflammatory effect in the body.  With magnesium being actively required by 1,000 enzyme systems in the human body, internal functions that reduce inflammation with the help of magnesium are being newly discovered every year. For example, magnesium has been found to be a natural calcium channel blocker, which is crucial because calcium in excess is one of the most pro-inflammatory substances in the body.  This is why I  recommend a 1:1 balance of calcium with magnesium, while also taking into account the amount of calcium people get in their daily diets.  Zinc  In addition to magnesium, zinc plays a critical role in controlling the inflammatory response. A study from researchers at Oregon State University has found that improving zinc status through diet and supplementation may reduce the risk of inflammatory diseases. It has been known for decades that zinc has a significant role in immune function and zinc deficiency has been linked to increased inflammation in chronic disease and triggering new inflammatory processes.  Omega Algae A+E  One of the tremendous benefits of saturation with essential fatty acids is lowering inflammation. They are both important fatty acid components of cell membranes that contribute to the structure, fluidity, flexibility, enzymatic activity, and signaling between cells. Vitamin A is one of the most common vitamin deficiencies in the world and also has a role as an anti-inflammatory agent. and vitamin E is a potent antioxidant with anti-inflammatory properties.  When used properly, the omega's along with vitamin A and E help reduce inflammation and improved the immune response. They increase the activation of macrophages, neutrophils, and dendritic cells (the first-responders that help identify pathogen or virus in the case of an infection), T-cells (that destroy the pathogen or virus), and B-cells (to remember the pathogen or virus and act immediately to destroy it in the case of a future infection), among others.  Vitamin D3  Beyond its critical function in calcium homeostasis, vitamin D has recently been found to play an important role in the modulation of the immune/inflammation system via regulating the production of inflammatory cytokines and inhibiting the proliferation of pro-inflammatory cells.  Lifestyle Choices  Lifestyle choices play a significant role in an individual's susceptibility toward chronic inflammation as well. Dr. Dean points out, “Chronic, low-grade inflammation—sustained by excessive belly fat, a poor diet including processed foods and sugars, lack of exercise, smoking, and gum disease—may explain why lifestyle-related diseases have reached epidemic proportions in Western countries while remaining relatively scarce in the developing world.”  Incorporating nutrients is a choice one can make to prevent heart disease, diabetes, and metabolic syndrome which makes knowing about these nutrients vitally important.  Tonight on our LIVE podcast on YouTube, we'll be talking with Dr. Carolyn Dean about her recommendations for controlling inflammation along with a wide range of health topics and safe solutions. You will love hearing the beneficial interactions with our callers and hosts alike including the body/mind connection, identifying the ‘conflict' in the ‘conflict basis' of disease, and much more!!  About Dr. Carolyn Dean    Dr. Carolyn Dean MD ND has been featured on national media for over 30 years offering practical strategies to improve health, vitality, and well-being the natural way. As a medical doctor, naturopath, certified clinical nutritionist and master of many modalities including acupuncture and homeopathy, Dr. Carolyn Dean MD ND has authored over 33 books and 100 publications including The Magnesium Miracle, 3rd Edition, Hormone Balance, Future Health Now Encyclopedia and Heart Health. Please note that the information and opinions expressed on these broadcasts are not designed to constitute advice or recommendations as to any disease, ailment, or physical condition. You should not act or rely upon any information contained in these broadcasts without seeking the advice of your personal physician. If you have any questions about the information or opinions expressed during these broadcasts, please contact your doctor.  Video Version:  https://youtu.be/gFDgbRB1BbA Disclosure: Dr. Dean does have a financial interest in the sale of all the Completement Formulas.  Call in and Chat with Dr. Dean during Live Show with Video Stream: Call 646-558-8656   ID: 8836953587 press #.  To Ask a Question press *9 to raise your hand  Dr. Dean takes questions via email. Please write questions@drcarolyndeanlive.com We will be glad to respond to your email  Learn more about Dr. Carolyn here: https://drcarolyndeanlive.com   Chatline on Station: http://bit.ly/Dreamvisions7Radio_Network

Your body’s inflammatory response is a healthy and necessary way for the body to protect itself. However, when that response stays on and inflammation persists, problems arise. Learn all about chronic vs. acute inflammatory responses in this episode of the Thorne Podcast. During this episode you’ll learn about: Younger generations and wellness [2:00] Fine-tuning wellness [2:48] Mainstream wellness [3:00] Inflammation [5:50] Leaky gut [6:36] Chronic inflammation vs acute inflammation [7:00] History of our understanding of inflammation [7:15] Acute inflammation [7:52] Chronic inflammation [8:50] Leaky gut and inflammation [10:20] Microbiome [10:45] NSAID [11:30] Gut health and the body’s inflammatory response [14:00] Antibiotics [16:13] Stopping symptoms but not understanding why [17:20] Inflammation is the body trying to tell you something [17:50] Questions from the community [20:50] Is inflammation ever a good thing [21:12] Defending your body [21:36] Problems [21:36] How is someone that’s young have arthritis [23:21] Microbiome [24:24] Why are some foods inflammatory [27:15] Are there places in the body that have no inflammatory response? [29:35] Supporting a healthy inflammatory response [30:37] Diet [31:07] Food Inflammatory Test [31:56] Supplements [32:30]               Resources to topics mentioned in this episode: CRP and Inflammation – This Blog Post Could Save Your Life Are You An Athlete Who Suffers From Leaky Gut? Body Basics: Understanding How the Gut Acts as a Protective Barrier Self-Care Approaches To Treating Pain From Mayo Clinic Why We Should Rethink The Western Diet Subscribe To More Content Make sure to never miss an episode by subscribing to the show on your podcast app. You can also learn more about what we talked about by visiting Thorne.com and checking out the latest news, videos, and stories on Thorne’s Take 5 Daily blog. * These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

The inflammatory and immune response are complex systems that help protect and heal our body and prevent disease. But then why do we take anti-inflammatories? Should I not be icing my twisted ankle? Can't inflammation be bad? Let's discuss all of this in Episode 10 of the Back to Basics podcast! --- Support this podcast: https://anchor.fm/guardianpodcast/support

It’s been a year, but people with arthritis still have many questions about how COVID-19 will affect them. In this episode, Dr. Ted Mikuls, a rheumatologist and researcher at the University of Nebraska Medical Center, helps answer questions about the new COVID-19 vaccines, emerging variants of the virus, and all that we have learned in the year since the pandemic began. Visit the Live Yes! With Arthritis Podcast site to read the blog and get show notes and a full transcript: https://arthritis.org/liveyes/podcast We want to hear from you. Tell us what you think about the Live Yes! With Arthritis Podcast. Get started here: https://arthritisfoundation.az1.qualtrics.com/jfe/form/SV_ebqublsylCl7BIh Special Guest: Ted R Mikuls, MD.

Commentary by Dr. Douglas Mann

Today's topic is the last episode in the four part mini-series on energy. Today we will learn how to build resilience to increase and maintain your energy. Topics covered include: Gentle Loving Kindness, The Domino Effect, Nature, and the Inflammatory Response.

http://myvitalc.com/minddog Use promo code minddogtvSponsors: https://apply.fundwise.com/minddog

Celiac disease is a well-documented autoimmune disease triggered by exposure to the dietary proteins found in wheat, rye, and barley.  Celiac disease affects less than 1% of Americans yet many more people claim to be sensitive to gluten. When people with celiac disease eat gluten, their body mounts an immune response that attacks the small […]

HOUR 2Zinc-an Anti-inflammatory Mineral--Carolyn Dean MD ND Many doctors and research scientists now believe that most chronic diseases may have the same root cause: Inflammation. Chronic low-grade inflammation has been linked to heart attacks, strokes, type 2 diabetes, Alzheimer’s disease, compromised immune and respiratory function and even cancer. There are a variety of drugs, medications and treatments available to address inflammation, ranging from over-the-counter medicines such as ibuprofen to more serious, prescription-only drugs. Drug companies are constantly searching for new anti-inflammatory drugs that are ‘safe’ to use. Dr. Carolyn Dean, a qualified medical doctor and experienced naturopath, argues that new drugs are not the way forward when treating many cases of inflammation. In her book, The Magnesium Miracle – Dr. Carolyn Dean talks effusively about how allopathic doctors and pharmaceutical companies are ignoring evidence that shows how many of these treatments, along with the accompanying side effects, would be rendered unnecessary were they to focus more on magnesium and mineral deficiencies. For example, our listeners who have followed Dr. Dean over the years know magnesium is an anti-inflammatory mineral. A breakthrough study from 2006 entitled Magnesium and the Inflammatory Response shows that at the cellular level, magnesium reduces inflammation. In the animal model used, magnesium deficiency is created when an inflammatory condition is produced. Increasing magnesium intake decreases the inflammation. In a more recent study [June 2017], therapeutic levels of magnesium supplementation are shown to have a positive anti-inflammatory effect in the body. Dr. Dean adds, “With magnesium being actively required by 1,000 enzyme systems in the human body, internal functions that reduce inflammation with the help of magnesium are being newly discovered every year. For example, magnesium has been found to be a natural calcium channel blocker, which is crucial because calcium in excess is one of the most pro-inflammatory substances in the body. This is why she recommends a 1:1 balance of calcium with magnesium, while also taking into account the amount of calcium people get in their daily diets.” In addition to magnesium, zinc plays a critical role in controlling the inflammatory response. A study from researchers at Oregon State University have found that improving zinc status through diet and supplementation may reduce the risk of inflammatory diseases. It has been known for decades that zinc has a significant role in immune function. Deficiency has been linked to increased inflammation in chronic disease and triggering new inflammatory processes. Zinc has become a nutrient of interest in 2020, with many virologists and hematologists reviewing its benefits for the mitigation of infection. In this study, researchers point out: As zinc is essential to preserve natural tissue barriers such as the respiratory epithelium, preventing pathogen entry, for a balanced function of the immune system and the redox system, zinc deficiency can probably be added to the factors predisposing individuals to infection and detrimental progression of COVID-19. Additionally, due to its direct antiviral properties, it can be assumed that zinc administration is beneficial for most of the population, especially those with suboptimal zinc status. Lifestyle choices play a significant role in an individual’s susceptibility toward chronic inflammation as well. Dr. Dean points out, “Chronic, low-grade inflammation—sustained by excessive belly fat, a poor diet including processed foods and sugars, lack of exercise, smoking, and gum disease—may explain why lifestyle-related diseases have reached epidemic proportions in Western countries, while remaining relatively scarce in the developing world. The many studies acknowledging the value of magnesium, zinc, and the other minerals found in our products as key to the prevention of heart disease, diabetes, and metabolic syndrome make knowing about this mineral vitally important.” Tonight on our internet based radio show, we’ll be talking with Dr. Carolyn Dean about Zinc An Anti-Inflammatory Mineral and a wide range of health topics and safe solutions. You will love hearing the beneficial interactions with our callers and hosts alike including the body/mind connection, identifying the ‘conflict’ in the ‘conflict basis’ of disease and much more!! Call in and Chat with Dr. Dean during Live Show with Video Stream: Call 646-558-8656   ID: 8836953587 press #.  To Ask a Question press *9 to raise your hand Dr. Dean takes questions via email. Please write questions@drcarolyndeanlive.comWe will be glad to respond to your email Learn more about Dr. Carolyn here: https://drcarolyndeanlive.com  

HOUR 1Zinc-an Anti-inflammatory Mineral--Carolyn Dean MD ND Many doctors and research scientists now believe that most chronic diseases may have the same root cause: Inflammation. Chronic low-grade inflammation has been linked to heart attacks, strokes, type 2 diabetes, Alzheimer’s disease, compromised immune and respiratory function and even cancer. There are a variety of drugs, medications and treatments available to address inflammation, ranging from over-the-counter medicines such as ibuprofen to more serious, prescription-only drugs. Drug companies are constantly searching for new anti-inflammatory drugs that are ‘safe’ to use. Dr. Carolyn Dean, a qualified medical doctor and experienced naturopath, argues that new drugs are not the way forward when treating many cases of inflammation. In her book, The Magnesium Miracle – Dr. Carolyn Dean talks effusively about how allopathic doctors and pharmaceutical companies are ignoring evidence that shows how many of these treatments, along with the accompanying side effects, would be rendered unnecessary were they to focus more on magnesium and mineral deficiencies. For example, our listeners who have followed Dr. Dean over the years know magnesium is an anti-inflammatory mineral. A breakthrough study from 2006 entitled Magnesium and the Inflammatory Response shows that at the cellular level, magnesium reduces inflammation. In the animal model used, magnesium deficiency is created when an inflammatory condition is produced. Increasing magnesium intake decreases the inflammation. In a more recent study [June 2017], therapeutic levels of magnesium supplementation are shown to have a positive anti-inflammatory effect in the body. Dr. Dean adds, “With magnesium being actively required by 1,000 enzyme systems in the human body, internal functions that reduce inflammation with the help of magnesium are being newly discovered every year. For example, magnesium has been found to be a natural calcium channel blocker, which is crucial because calcium in excess is one of the most pro-inflammatory substances in the body. This is why she recommends a 1:1 balance of calcium with magnesium, while also taking into account the amount of calcium people get in their daily diets.” In addition to magnesium, zinc plays a critical role in controlling the inflammatory response. A study from researchers at Oregon State University have found that improving zinc status through diet and supplementation may reduce the risk of inflammatory diseases. It has been known for decades that zinc has a significant role in immune function. Deficiency has been linked to increased inflammation in chronic disease and triggering new inflammatory processes. Zinc has become a nutrient of interest in 2020, with many virologists and hematologists reviewing its benefits for the mitigation of infection. In this study, researchers point out: As zinc is essential to preserve natural tissue barriers such as the respiratory epithelium, preventing pathogen entry, for a balanced function of the immune system and the redox system, zinc deficiency can probably be added to the factors predisposing individuals to infection and detrimental progression of COVID-19. Additionally, due to its direct antiviral properties, it can be assumed that zinc administration is beneficial for most of the population, especially those with suboptimal zinc status. Lifestyle choices play a significant role in an individual’s susceptibility toward chronic inflammation as well. Dr. Dean points out, “Chronic, low-grade inflammation—sustained by excessive belly fat, a poor diet including processed foods and sugars, lack of exercise, smoking, and gum disease—may explain why lifestyle-related diseases have reached epidemic proportions in Western countries, while remaining relatively scarce in the developing world. The many studies acknowledging the value of magnesium, zinc, and the other minerals found in our products as key to the prevention of heart disease, diabetes, and metabolic syndrome make knowing about this mineral vitally important.” Tonight on our internet based radio show, we’ll be talking with Dr. Carolyn Dean about Zinc An Anti-Inflammatory Mineral and a wide range of health topics and safe solutions. You will love hearing the beneficial interactions with our callers and hosts alike including the body/mind connection, identifying the ‘conflict’ in the ‘conflict basis’ of disease and much more!! Call in and Chat with Dr. Dean during Live Show with Video Stream: Call 646-558-8656   ID: 8836953587 press #.  To Ask a Question press *9 to raise your hand Dr. Dean takes questions via email. Please write questions@drcarolyndeanlive.comWe will be glad to respond to your email Learn more about Dr. Carolyn here: https://drcarolyndeanlive.com  

Anytime people talk about "workout recovery", there are a few recommendations that seem to be very common. If you browse the internet for "workout recovery methods", a few strategies that you are bound to come across are:Epsom salt bathsIcing Post-workout protein intakeThese methods have been popular for years and continue to be implemented by anybody looking to heal after a workout. But how did these recovery tactics originate? Are they based in evidence or essentially myth? This week, Andy and Aaron look at the evidence behind the 3 common workout recovery tactics to see just how beneficial they actually are. Learn more on InstagramWatch us on YouTubeVisit our WebsiteResources:Magnesium in Man: Implications for Health and Disease Magnesium in Prevention and TherapySuboptimal Magnesium Status in the United States: Are the Health Consequences Underestimated?Magnesium Enhances Exercise Performance via Increasing Glucose Availability in the Blood, Muscle, and Brain During ExerciseMyth or Reality—Transdermal Magnesium?University of Birmingham Epsom Salt Bath ExperimentDoes Epsom Salt Work?Why Ice Delays RecoveryWhat Is the Evidence for Rest, Ice, Compression, and Elevation Therapy in the Treatment of Ankle Sprains in Adults?Effect of Local Cold-Pack Application on Systemic Anabolic and Inflammatory Response to Sprint-Interval Training: A Prospective Comparative TrialNutrient Timing: The Future of Sports NutritionInternational Society of Sports Nutrition position stand: Nutrient timingNutrient timing revisited: is there a post-exercise anabolic window?The effect of protein timing on muscle strength and hypertrophy: a meta-analysisDisclaimer: This podcast is not intended to provide medical advice, diagnosis or treatment. The products, information, services and other content provided on and through this podcast, including information that may be provided in the show notes (directly or via linking to third-party sites), are provided for informational purposes only. Please consult with your physician or other healthcare professional regarding any medical or health-related diagnosis or treatment options.

recorded lecture for NURS 2003 --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

Inflammatory Response --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.12.090688v1?rss=1 Authors: Morshed, N., Ralvenius, W. T., Nott, A., Watson, L. A., Rodriguez, F. H., Akay, L. A., Joughin, B. A., Pao, P.-C., Penney, J., LaRocque, L., Mastroeni, D., Tsai, L.-H., White, F. M. Abstract: Alzheimer's disease (AD) is characterized by the appearance of amyloid-beta plaques, neurofibrillary tangles, and inflammation in brain regions involved in memory. Using mass spectrometry, we have quantified the phosphoproteome of the CK-p25, 5XFAD, and Tau P301S mouse models of neurodegeneration. We identified a shared response involving Siglec-F which was upregulated on a subset of reactive microglia. The human paralog Siglec-8 was also upregulated on microglia in AD. Siglec-F and Siglec-8 were upregulated following microglial activation with interferon gamma (IFNg) in BV-2 cell line and human stem-cell derived microglia models. Siglec-F overexpression activates an endocytic and pyroptotic inflammatory response in BV-2 cells, dependent on its sialic acid substrates and immunoreceptor tyrosine-based inhibition motif (ITIM) phosphorylation sites. Related human Siglecs induced a similar response in BV-2 cells. Collectively, our results point to an important role for mouse Siglec-F and human Siglec-8 in regulating microglial activation during neurodegeneration. Copy rights belong to original authors. Visit the link for more info

Inflammatory Response and Infections For access to blog, video, article, shareable quotes: advancednaturopathic.com/Inflammatory-Response-and-Infections/ Get Dr. Roberts’ new book: http://advancednaturopathic.com/building-a-healthy-child/ Join Us on Facebook: https://www.facebook.com/AdvancedNaturopathic/ Follow Us on Twitter: https://twitter.com/drmelinaroberts -------------------- ABOUT DR. MELINA ROBERTS ------------------- Dr. Melina Roberts is a Naturopathic Doctor, Author of Building a Healthy Child, Founder and Clinic Director of Advanced Naturopathic Medical Centre in Calgary. She is a leading authority in the field of naturopathic medicine specializing in European Biological Medicine effectively treating digestive issues, chronic disease and cancer. ------------------- ABOUT ADVANCED NATUROPATHIC MEDICAL CENTRE ------------------- Advanced Naturopathic Medical Centre is Canada’s Comprehensive Centre for Biological Medicine. We are a patient-focused, professional medical practice that utilizes advanced, comprehensive testing and therapies to help people of all ages and all levels of health to be able to reach their optimal health. Visit our website: advancednaturopathic.com ------------------ SUBSCRIBE ------------------ Never miss a video and join our YouTube community: https://www.youtube.com/user/drmelinaroberts

Today we’re talking about the innate immune system, the inflammatory response, and the cytokine storm, particularly in the context of pathogenic infections and the role of herbs like echinacea, astragalus, and Andrographis. Featuring special guest Kerry Bone.

In this episode of Bulletproof Radio, I get into inflammatory responses and the lessons pain teaches us with my guest, Dr. David Liepert. “COVID is doing damage by overwhelming us and causing uncontrolled inflammation,” he says. “The inflammatory response to COVID is actually somewhat protective. The question is, at what point does it become counter-protective, or even counterproductive, or even producing injury? The same thing is true systemically, that, for instance, social distancing and quarantine are kind of a social form of inflammation.”“Basically, uncontrolled inflammation is another way to think of a cytokine storm,” he says. “Cytokines are meant to be the solution, but uncontrolled, they literally become the thing that's killing us, rather than helping us get better.”Dr. Liepert a physician with a broad range of expertise in critical care, specialty anesthesiology, and quality improvement and assessment programs within Canada’s healthcare system. He’s dedicated much of his professional work to helping patients find solutions to chronic pain. He also serves as chief medical officer and advisor to several companies leading development and discoveries for mobile health and wellness monitoring, and AI solutions.I asked him to talk more about how this type of virus (Covid-19) is bringing our health systems down, not just us individually.“My one big struggle with academic medicine and the way it responds to situations like this is, academic medicine assumes we know what questions to ask,” Dr. Liepert says. “And if we don't even know what question to ask, we're never going to find the right answer.”Enjoy the show! And get more resources at https://blog.daveasprey.com/category/podcasts/.

In this episode of Bulletproof Radio, I get into inflammatory responses and the lessons pain teaches us with my guest, Dr. David Liepert. “COVID is doing damage by overwhelming us and causing uncontrolled inflammation,” he says. “The inflammatory response to COVID is actually somewhat protective. The question is, at what point does it become counter-protective, or even counterproductive, or even producing injury? The same thing is true systemically, that, for instance, social distancing and quarantine are kind of a social form of inflammation.”“Basically, uncontrolled inflammation is another way to think of a cytokine storm,” he says. “Cytokines are meant to be the solution, but uncontrolled, they literally become the thing that's killing us, rather than helping us get better.”Dr. Liepert a physician with a broad range of expertise in critical care, specialty anesthesiology, and quality improvement and assessment programs within Canada’s healthcare system. He’s dedicated much of his professional work to helping patients find solutions to chronic pain. He also serves as chief medical officer and advisor to several companies leading development and discoveries for mobile health and wellness monitoring, and AI solutions.I asked him to talk more about how this type of virus (Covid-19) is bringing our health systems down, not just us individually.“My one big struggle with academic medicine and the way it responds to situations like this is, academic medicine assumes we know what questions to ask,” Dr. Liepert says. “And if we don't even know what question to ask, we're never going to find the right answer.”Enjoy the show! And get more resources at https://blog.daveasprey.com/category/podcasts/.

Dr. McKenna has successfully treated an incredible array of diseases, inside and outside of orthopedics with stem cells. McKenna has been on the front line of stem cells and their clinical application for decades. If you have ever wanted to know the vast array of proven applications for stem cells, do not miss this episode. What stem cells are, how they work, where they are and are not taken from, why cord blood and PRP are NOT the same as stem cells technology used today, the issues of the FDA, his association with RMI (Riordan, McKenna Institute for stem cells with Neil Riordan), treating Mel Gibson and other celebs & lawmakers, the future of research in stem cells, why all SC healthcare providers are not practicing equally (or ethically), why Panama & the Bahamas are used for advanced stem cell therapy and more.https://TheCellSpa.comhttps://drwademckenna.comAtrantilhttps://lovemytummy.com/spoonyProlon Fastinghttps://prolonfmd.com/isreferral.html?p=KBMD&w=FMDhttps://kbmdhealthhttps://gutcheckproject.comHey hi Mandy if you don't know me it's probably because I'm not famous but I did start a men's grooming company called Harry's the idea for Harry's came out of a frustrating experience I had buying razor blades most brands were overpriced overdesigned and out of touch and here is our approach is simple here's our secret we make sharp durable blades and sell them at honest prices for as low as two dollars each we care about quality so much that we do some crazy things by world-class German blade factory obsessing over every detail means were confident in offering 100% quality guarantee millions of guys have already made the switch to Harry's so thank you if you're one of them and if you're not we hope you give us a try with the special offer get a Harry starter set with a five blade razor weighted handle shave gel and a travel cover all for just three bucks plus free shipping just go to Harry's.com and enter 5000 at checkout that's Harry's.com code 5000 enjoy all life we are here with a gadget project this is episode number seven on marriage for you here with your host Dr. Kendra I was going on today good morning good morning how you doing I am doing well how are you doing this more well than what I am on the day number four of the fasting mimicking diet how about you I am also on day four the fasting mimicking diet made by prolonged made by prolonged so I want do a shout out to Dr. Joseph onto the CEO prolonged and Dr. Walter Longo who wrote the longevity diet they sent us some prolonged kits and were given a shot the fasting mimicking diet they are it is the fasting mimicking diet so I am comparing it to a previous experience of doing a water fast it's very interesting and this is far more tolerable quite honestly and just this morning I did check key tone levels I was it 2.2.1 date date three you're supposed to start doing it so by as this day goes on you probably start kicking up a whole lot more yeah so I found that to be beneficial it's only falling in line with what you want I did comparing this to a water fast at this point I was big meal for being in three nap days I feel like I was really ready to start eating the by day four that was enough for me I did dad it four full days of the water fast but with Pro line I feel actually feel really really good it's not too bad it is nice the way they can portion out every days meals what were going to be eating so my wife's doing with this also the only hard part was it earlier this early this week I had to cook dinner for the boys because they still gotta eat and family had some nice juicy steaks to sit there and you can have any of it I couldn't do anything with it was not the box about yourself how was yours will I'm you I'm doing well this is my fourth five day fast I guess is a little over year trying to do them every few months I first want to prolong which is not a big deal all second one I did kind of my own little fasting and keep mimicking style I didn't have that what I'm in a call that burst of energy right or possibly it was stimulation of stem cells listed in that in a few minutes here and then I did a water fast only my ketones went through the roof but I was quite miserable sore back to the prolonged given this a shot and we'll talk about that in the second but I mention the stem cells today's guest while this is going to be if you know anybody to have autoimmune disease if you know anybody that has back pain anybody has joint pain to an end because we have a stem cell expert Dr. Wade McKenna orthopedic surgeon skies a bad ass in this field and we were sitting there talking just outside I'm like holy cow I'm just considering take notes like we brought in a professor of stem cells may ease size pretty amazing how he actually played football at Oklahoma State went to med school I perform indices with him several years ago whenever he was still heavily just as he is today doing orthopedics he's a fantastic surgeon all of this is led to somebody's actually can remind me you he never wants to stop learning and so it's it's led to areas where he is today and he is I would say quite the expert with stem cells and where the future is going with them so this is so exciting that we have to time to fast for this episode because you know people throw around the word stem cell a whole lot and much like the CBD industry people throw around there's lots of misinformation there's lots of quality differences the people that are actually giving stem cells there's lots of differences with that so we could clarify all of it I really feel like there's some parallels you and I have brought in several CBD experts right and there's some parallels here and so you know this is a super exciting for that anything going on with the family anything going on socially well this last week whenever Morreale moved into preparing to do this fast I would say that the boys have the have enjoyed teasing us and other than that they've they thought back into all season basketball quite busy and is kind of the every day as usual at the round Renner household self typical tennis weekend both the Lucas and Karla were playing tennis and they both did really well it was kind of a little curb although I'm really proud of my team because as working to be launching the D hat health box Dr. Lisa Alvarez actually did a little commercial for she did so yeah and so do I get a chance to pop into the set see it the move honestly try to see what that happens I appreciate her taking her time to do that so another chemical thing I just go phone with Dr. Chang Ron Houston yeah great guy fantastic functional medicine doctor he actually has ties with prolonged him and him and Joseph were friends okay to be having a huge conference coming up on April 27 were he to talk about brain got issues where you have them on the show because he's got some incredible stuff on brain waves and its affect pre-and post trauma and its effect pre-and post-diet change and using hemp dry products so super cool I just have a phone with him so to get a chance go to his Facebook page a lot of really cool information so awesome I think the work on the move and all these unique directions right but what's the big deal stenciled what we want to talk about I think that it's it's the newest new frontier it's no different than the way we've been spending time talking about CBD why why just a few years ago the revelation that you had into polyphenols and how I could do these are it's a lot of what nature is giving us to work with and it's kind of amazing that it's it's all coming to fruition nowadays and you hit on it a little bit earlier I know that the Dr. McCann is going to address it as well the FDA it many times when we want this government entity to be on our side in helping us out can really be stymieing a lot of the progress that many of the citizens could be enjoying that they could be taken party to have a better quality of life and in a really odd yet when you get down to money reason you find out that the FDA is is hard to budge out of the way in in terms of progress so interesting because what he was talking about is exactly what I've been doing so in in all fields of medicine it's very hard to change the direction of this large Titanic like shipper people doing things and we have either many ways as he said as he described it to skin a cat or really none of them really working very well sure and then when you find something it's hard to get people to pay attention to much like trying to write I mean when we sit there when we came in without her until we know that mojo and 5.0 guys are talking there really trying to tell everybody about the bloating effects with it but we know that our trenches made up of polyphenols and we know those polyphenols are really good for you they actually are the antiaging and anti-inflammatory molecules in the Mediterranean diet so we need to expand that message a little bit more rhino people hey you can take these polyphenols which are in trying to and they can actually do some of the things Duncan that stem cells do and we can talk about this in some science but if you're curious about that if you looking at upfront Hills or any place that you go where they should go to love my tummy.com Ford/spoony that's love my tummy.com/spoony and then use the code spinning Sabal cash while you pick up your own polyphenols to be delivered right to your home and then keep listen to this because you do realize that these there's lots of overlap chain runs you to be doing a brain gut thing where he shows that you need to protect your gut I'll try to help with that we got Wade McKenna here talked about stem cells the body wants to rejuvenate itself you need to give it the things that can this is going to be so excited working a really geek out today I am the earliest I want to definitely I want to hang in there because what you learn is literally some of those cutting edge stuff you meant Dearborn stem cells person to make a circuit in the news and it's really odd the way the people began to report new science and health sometimes it can be this is the greatest thing ever or it can be a lot of scare tactics in our member the first time I heard about stem cells it was the unfortunate been taken from unborn babies etc. but that's not what's happening in all when you begin to get past that layer will guess what it's just like anything else you get past the first layer and then you find that there's a whole new world to discover and in terms of what Dr. McCann is going to talk about we have lawmakers here in the US to prohibit certain strip certain lines of stem cells being used but they are still incredibly beneficial and some of the culturing over the growth of those stem cells and do what the US would state would determine to be tissues they couldn't do it here they could do in Panama and oddly enough who found his work in Panama always couple lawmakers really kind of the good kind of weird and ironic that the same people there are part of that institution it doesn't allow us to do certain things will go out of the country to get that kind help is such a small world and its fate in whatever it is I think a lot of things that have happened in both our lives have been opportunities that we take advantage of and I love you and I were working one day and I was like dude did you see that Joe Rogan we had Mel Gibson on and some other guys some PhD knew it yeah I know those guys and I was like laughing because no Gibson said the same thing a lot of people think is like you think about stem cells you have a mouth going up the side of your face and now not at all as it turns out he took his dad down to Panama and his nonmaterial dad and he got better and that's what I was like whoa and you started saying to me this is a long time you're over your half your menu go to meet my buddy Wade because he's doing a lot of the same thing same parallel paths and since it is really scientific and is just trying to get people better that's it a year of your right on and just think about that so that being at least 18 months ago I believe that Mel's dad was started going down there maybe five years ago think of the advances in the tank and the technologies that have come along with stem cell research and send that's exactly why Wade Dr. Wei McCann is here to tell us a little bit more about where it's going how you going to measure what is authentic stem cell injection what is there the right protocol what you be looking for who are the imposters there's a there's a lot of information out there it's no different than learning about CBD and where to go get the right kind of CBD of its harvest of the Rahway producer away I just think it's it stinks I went to a doctor friend of mine Dr. Marlon Padilla and we are in his office and he just are talking about I'll check this out I'm now doing stem cell know the quote you have stencil expert on this week you go take a listen easier is it Hillcrest medical and University Park area… Having super great guy very innovative himself trying new things yeah and you he started do that like that small world some sort to pay attention to all these things so one of these lectures get caught up on everything that sewer pursuer at night to geek out a little bit so how I Titus altogether how to retire fasting together how to get stem cells and how we come full circle to discuss what's out there in the literature about what were passionate about also write well it's kind interesting because what were doing with that with that diet selection are trying to heal CBD fasting and learning that stem cells you find I think for all of our listeners as well as us this is all synergistic there's a reason why we're Gerber took the mail here with this kind of message so using our graduate student that always helps us out we've got some really cool articles kinds altogether, and with what I consider really geeky stuff I want you to hang in there for me okay so the first question is your on day four of the prolonged fast why the world even doing that well it has been shown that in cellular metabolism in July 2015 summarize whatever you and will fast it promotes stress resistance so basically when you're put on a fasting mimicking diet or I should back up we've always known that the caloric restriction diet has been shown in yeast and other animals to prolong life Walter Longo in his book figure out a way that you can eat a little bit and trick your body to believe that it is completely fast that's the fasting mimicking diet is so this study in 2015 looked at putting mice on the fasting limiting diet and they demonstrated that these mice decrease the size of multiple organs improved glucose control decreased visceral fat lower blood pressure improved bone mineral density rejuvenated the immune system and reduce cancer risk always too good to be true and Academy just five days three times a year and can accomplish this but wait there's more we got more here they also showed after they re-fed the mice solicit what this is the coolest thing about this when you listen to vaulter give lectures he said it's not so much the fast it's the recovery from the fast because when they re-fed him they showed that in older mice areas of the brain like the hippocampus showed neurogenesis and improved cognitive performance while yeah so it's pretty wild with the re-feeding that super important which makes it fun because on Monday for I'm really looking to some refuted yeah can't wait for some re-creating but any that's all part of the process I will say going through at my second fast that this is becomes easier it's it's not as hard as the first run of some that's with prolonged but it is the expectation is they are know what to expect I know struggle for so what would be contributing to better neural thinking that is you a question so the question is what's going on there so then we dug up an article in the Journal of stem cell research in 2016 what they showed is that fasting protects against immune system damage and induces regeneration by waking up stem cells or by catalyzing dormant stencils so all those what they realize is what this article describing is what vulture was figuring out right there what he had figured out that all comes down to stem cells at the refuting stage basically not with her not stenciled several times which is to find what is real quick stem cells are the body's raw material their pre-sells for all other cells stem cells are the only cells that can generate new cell types and they can divide into form what are called daughter cells which become specialized cells that eventually come specific organs that's all me to say about it because wage may come in here and blow our minds until us a whole lot more with what stem cells are so for my all intensive purposes on coming here knowing stem cells can become other cells – easier to tell us way more with that so basically after you fast and then you re-feed you flip a regenerative switch which promotes stem cell regeneration in the blood making organs so that the important thing so when you go into starvation mode the body will save energy and one ways to recycle immune cells and that causes autophagy so old and sick and dying cells are programmed to hate go away right and then the autophagy gets rid of the old site sells them when you re-feed the stem cells wake up and they go around there's a bunch of fallen soldiers they don't bother them but they go around and say we need new people to replace this over simplistic way to lead into a much cooler explanation of that and then with each cycle you re-feed you get rid of sick and dying cells and replace them is like a janitor it's exactly like a janitor so five day fast three times a year you just cannot quit you just doing some serious housecleaning I member Saturn panda when he talks about that that's the godfather of circadian rhythm fasting or intermittent fasting right he's got mouse models he still does a prolonged fast because he describes it as you brush your teeth every day and then you a couple times a year you going to get the deep cleaning from the dentist I like that analogy you're always doing maintenance which is you keep in the nine date of of what you're eating but every once while you get to do that deeply definitely and then trying to fast for the first time you you can look at you like why would I not want to eat but if you look at the history of time where people were in the movement nowadays to return to health where people are trying to get healthier and you look at things like Paleolithic's for instance they talk about new diets and ways to eat in a pale lifestyle some of that also includes fasting and the reason is the primal man also went a long time without having food and for a few days at a time they would have intermittent fasting org or a few days fasting themselves yeah and so basically you're just returning to what it is that we've all been programmed to do for a long time that it just so happens the last several generations we've had ubiquitous amount of food here in the US and so now we it'll thicker bigger let's okay so this is no doubt about it feet eating is awesome right but eating is an inflammatory process so when you eat your you to become inflamed a little bit and then you incorporate the nutrients and so will the way that were doing and how will we eat so much it's probably not the healthiest way so right now where the fast let's talk about was actually a lot going on with our bodies before talk about Howard to tie all this together two stencils. So day one this is basically the five defenses what's happened to you and I so day one just upon your body day to start doing some fat burning day three start doing some cellular recycling basically you're going to clean up start realizing were on day three now for backing cavemen times they one day to that's normal day three your body starts going up oh we better get ready for something because were you have to go out and get some food soon and that's when you start doing the cleanup and this is when a lot of people will reach ketosis day for you and I right now are in this this is the cell regeneration this is where autophagy started yesterday in autophagy is when those old sick and dying cells are programmed to go away much like we talked about with the polyphenols when they get in there in your list and causes my top a G5 in the foods we eat will do that then this starts artists are stem cell-based regeneration is starting to ramp up so when people talk about how I fascinated 24 hours 09 and identity a fast we've come this far when were this far into it tomorrow's what all the real magic happens all the magic day five regeneration continues now we've turned on our stem cells and the body is being rejuvenated from with it now the first time you and I did this did this are fast I think it was tonight will this happen to both of us we both slept what two hours yeah I even so every time that a fast so far I feel great whenever I go to bed and feel really rested but don't last night that of the of my fast I basically went to bed and then I thought I woke up again as a man what a great night sleep again and I looked over the clock I been asleep for two hours and 15 minutes and then I sat around the house like what am I going to do for the rest this morning about tired right now and then later I learned that was over Rex and it was being released telling me I always forget that all Rex and O Rex and so is released from hormone release my brain saying it's time for you to go and eat and I had in them and an abundant oriented interview time for you to get up have the energy to go kill the woolly mammoth so that you can eat and you can feel it a mere year manic and it was time and you saw me run when I quit the fast I mean I think of the time I my blood sugar was 54 and and and I felt fine with that and at key tones I think for 4.8 and the moment that we drew ride today the labs and that in the blood that one time it was it's time to eat yeah so both of us have ever similar expenses this is the third day that we done this so now let a geek out here for the last four minutes because this is where I think it comes in really cool and so we found an article that has a really long title and I just like I like saying it just because I realize that this is the kind of stuff I'm reading ditto for the show treatment of periodontal ligament stem cells with Emil Warren CBD promote cell survival and Ronald differentiation via the P 13 K a K TM tour pathway that would scare most people scared me off at first but our graduate student said this is a fantastic article hundred 11 so basically what this whole article shows is you can get stem cells from a few places Dr. McKenna will explain where bone marrow fat but one of the places periodontal ligament so these are known as mesenchymal stem cells meaning that they are the least differentiated cells and they can trying to become anything so one of the important things is quality of stem cells keep that in mind because we'll talk about that coming up quality stencils so one of the things about stem cells is that there are a lot of different qualities but once you get the stem sellout you have to keep the stencil healthy so you have to keep it alive and you have to keep it in the best environment possible so there's different mediums to do this this study looked at taking stem cells out in vitro meeting in a dish and they bathed them in CBD and more range in MO R which is a program to sign a day in which is a polyphenol which is the same stuff that upfront deals made of so they they bathed them in CBD and in a polyphenol blend amazing supercool they did it for $40 and what they showed is that they demonstrated longer survival less a pop ptosis or programmed cell death decrease the M tour pathway the M tour pathways the pathway that makes cells grow right so bodybuilders lots and tour pathway but guess what cancer enter pathway also so to growth pathway increased differentiation capacity meaning they can become more of something quicker they increase nesting and DDN after which neurogenesis or new nerves new brain tissue right and then it did a deep dive into the genes that these stem cells turned on that gets into the cool epigenetic stuff that we talked about before base will have these genes so they concluded that in the field of stem cell research it may be improved by bathing them in CBD and a polyphenol mix so if you not get injected anytime soon might not be a bad idea to start from the inside using some CBD and possibly some upfront it sounds to me like the research is probably on the on the cusp ears are going into that that's why they're bathing them in the point assignment in the CBD but it's weird that just three weeks ago when we had Mark on he was talking about his D differentiated contra sarcoma test stem cells that basically were released and they didn't know exactly where to go they begin to proliferate and he even said it could be found in an organ anywhere in your body even when you feel like you taken so it's critically important that your stem cells are differentiated they get to the place they're going to be and do what you need them to do you don't want them growing out of control so maybe possibly will find on the future that combining a polyphenol set with a plant a point of sanity and CBD along with stem cell therapy would be a protocol I be awesome to get people started here or should they go to get I would eagerly for you go to K BMT health.com and go to the store you can find both are trying to heal and the new KB MD CVD or you can always go to love my tummy.com/spooning and hearing about four minutes really joined by the Dr. Wayne McKenna so if you know anybody that has joint issues back issues knee issues and take it one step further autoimmune disease there's so many things that now look into the science of stem cells that is going to be supercool to geek out and this guy knows his stuff I am excited to have youth if you had any questions about stem cells is the witness of the main unit turn to Dr. Wade McCain is going to join us here we can take a break in about 10 seconds thing wrap up now just thank you guys for the prolonged high talk Elson if you are trying to quit drinking or doing too many drugs listen to me you don't know me and will never meet I had a problem like you want I drank and used a party a little too much till he got out of control and almost ruined my life I realize I needed help to fix my problem before it totally destroyed me if you tried to fix your drinking and drug problem and you know you can't do it alone you need to call the national treatment advisors they'll immerse you into a 30 day program to replace your old habits with new habits and totally change your life and if you have PPL private health insurance the entire program may be covered fix your problem right now before it gets any worse get clean call now and learn more 800-296-1252 800-296-1252 800-296-1252 800-296-1252 it looks like you're losing I am I losing weight I am losing my lost about 10 pounds how are you doing it funny name but I done it with review zone RAD use zone.com and the stuff works it's you you get it all that the molecule this that found in that all I can tell you is it it's a it makes you feel full and he keeps your mind off of wanting to overeat and also boost your metabolism yes you're done and more guys try it today it's gonna work for you like his work for Brad and countless other people read you zone.com are IDUs owners.com fast track student loans can get your student loans out of the vault stop any wage garnishments stop collection calls and stop seizure of your tax refund give yourself a break to stop the stress and get your student loan payments down to as little as $25 a month based on what you can afford to pay 800-709-4395 800-709-4395 800-709-4395 800-709-4395 okay were back it's now the second half hour episode number seven of the gut check project we are now joined with Dr. Wade McKenna but McKenna thanks so much for coming in today really appreciate absolutely so see what I do know him yeah you know whatever no word of her Rhonda Patrick goes on Joe Rogan's economy gets better paper out you'll be taking some notes I favor Gerardi, Patrick never feels more like absolutely just a caveman. Dr. she's a lot of knowledge of sausage yellow management so you since you do already went through a couple of small things in the last half-hour you played football look on the state you been orthopedic surgeon for several years but that's not really what you here to talk about today the cool part is I actually can you hear we good we are little my problem were going to get something fixed here real quick right area is going the cool part for me they spent is kind of been allowed to reinvent myself as a traditional surgeon when the science, caught up to what we do and figure out that a lot of what we would think of as traditional medical approaches were less than optimal from patients and point so exited a fellowship in trauma and post dramatic reconstruction after an orthopedic surgery residency and after a general surgery internship so in during a general surgery internship when I thought I was going to do transplant surgery because that was the coolest guys at the hospitalists on which Trina here in Dallas Fort Worth multiple hospitals with DFW medical service rendered him orthopedic residency I did my fellowship and trauma to the general I was Roy Sanders 2000 but hospital where as to trauma fellows panorama the program we had 10 residents in for helicopters and no sleep with a whole new episode on what lack of sleep will do to your stem cells well it lack of sleep and not healthiest UW not like lack of sleep induced by fasting where you feel like Superman lack of sleep induced of note falling asleep in the boat in the lounge chair waiting for the nurse to tapping the short essays time to go from zero to hero so but during the trauma fellowship we became very adept because we got stuck with a lot of the fractures that other people treated heel so the posttraumatic part of that is acutely we were stabilizing multiple extremity injuries but we also do those people over multiple extremity injuries and we would get referred a lot of the trauma patients the gentleman traumas what we called it which comes to visit you in clinic does it come to you in the middle night by helicopter gentlemen trauma that watching your clinic is like I get this knife stuck out as well hey I've had five surgeries on my femur fracture I still can't walk and still no bonus I have is soon healed and we had to find a way to not only promote tried to trick the body and the human something that already showed didn't want to heal but in the least invasive way possible to turn the table can help the patient generate new bone best way to do that early on was Boomer us were concentrate the very Baston first uses of bone roster concentrated in traditional surgery was in the treatment of nonunion when someone has a fracture that doesn't heal there is delayed union which is means takes forever that but there's nonunion wishes means it doesn't heal there's no bone if you have a leg doesn't have a hip fracture can't walk can't but wait on it given upper extremity with an unhealed fracture pretty much flail you can you have a non-nonfunctional extremity bone rest will concentrate in the treatment protocol this allowed us to be much less invasive instead of just it doesn't make a lot of sense to just take out all the other plates and stripped the blood supply room muscle replay fracture further destroying the blood supply to the fracture that already the numbness blood supply to heal so let's go ahead and revisit that really quick because as a surgeon it's interesting to dear somebody because that's typically that's a knee-jerk reaction all that last surged and worked when he operated as exactly so say one more time with re-operating guys will here's the problem with re-operating if you didn't heal the first time it's because of the formation of scar tissue not healed tissue so the healing gets stopped the fibrotic tissue begins scar tissue hurts scar tissue does not much blood supply and scar tissue is very functional it's fibrotic it it can take up some space for the most part the difference between the interface between healthy tissue and scar tissue continues to be painful forever every time you move something severe big fibrotic knot of scar with an attendant and you have some healthy tissue that generate the connects to it the mismatch in pliability that mismatch of you would never use metals that have different hardness when you put together an engine it is the soft metal in the hard metal caused threading and corrosion in significant problems and and metal mismatch soft tissue mismatches just as big a problem we create scar tissue and people hurts generates pain generates an inflammatory response or chronic inflammatory response from cytokines that without decent blood supply to scar tissue you want to get rid of so you end up with long-term and continued muscle that and a lot of our surgery approaches and a lot of surgery where you just strip off the blood supply to the bone that it needs to help heal don't work very well because were not focused on how the body needs to really heal this fracture were focused on making x-ray and I did just make you look nice so your I think it's fascinating because essentially I've done the same I've done the same thing in my practice rub to move from traditional gastroenterology become almost a functional orthopedist yeah I would like to think that that I I just come to the table with some of the extra tools that I need to kinda set the table for the patient to help them heal I the body has unique ability to overcome a lot of things and in our body actually wants to heal a lot of times I'm just try to help people get our own way the same way the gastro neurology diet you're trying to help people get their own way from being about health right with with orthopedics I have to help the body the body knows the triggers and mechanisms and has the entire growth factors to help your body heal as we get a little older as we have chronic injury you rely radiation cigarettes coffee alcohol late nights cortisol stress we impair our body's ability to respond appropriately to injuries what the stem cell does for you is that the cell that helps you respond injury the problem is is you get a little older you have less of them and they don't do as much as a used I would guess that a second I'm still I want to hear the history only here got half because you ended with during residency restarted down do bone marrow concentrate bone marrow aspirate concentrate for nonunion fracture not only fractions your worst people so you guys were willing to try some things other people work well we had the opportunity because these people had no other options so the best part about doing a trauma fellowship is we were there last Hope we were the the Island of misfit toys so to speak Ryland Mr. Toyo we will use the we stood especially around Christmas time when that movie comes out with Chris Pringle we we would literally collect the injured patients from all over South Florida South North Florida Alabama Georgia we were the only level I trauma center on the West Coast of Florida and so when people would fail multiple surgeries we they walk into the resident clinic and you had to come up with a way to solve the problem and a lot of times it was as easy as finding a way to put more stress on the fracture you did have some plate that was plated and distraction so last times was just taken some screws out sometimes it was loosening up a frame that was holding the fracture apart and then let the fracture heal we would compress the frame so that the P0 electric effect fractures need stress to generate bone so stress across bone generates electronegative charge calcium and phosphorus are positively charged the biomechanics of basic physiology which unfortunately is certain's only when were supposed to forget that but apparently we do is trained out of us is what I was told the residence when the witnesses don't let don't let basic science and in physiology be trained out of you it into a surgical approach but when you create electronegative chars from a compression fracture calcium goes in and she get some healing without blood supply there is the rule in an osteopathic physician so it's a deal medical school because our team Dr. local state was the and and did manipulated felt good and I want to know how to do that I didn't even notice a difference on your will to be an orthopedic surgeon I said can I be an orthopedic surgeon because the he said absolutely yes that's about how I made that decision Okemos they had a deal medical school oh use was MD the last thing the world I wanted was a red diploma so state fans of loyalty I got a mistake know you was an easy decision I do know what the deal was but one of the owners of the time give me a book called the difference of genomics and you trying to teach me about the school just decided to go to and they said that when it comes to healing that the rule of the artery is supreme rule of the rings have the right to rule the artery is supreme but lymphatics have veto power I never heard this so that was the it's it's the foundation of a T still creation illustrate your stupid mess was created by the write a few stills and indeed he started the first year medical school in Kansas but he did it because he was unhappy with traditional medical approaches mobilization the joint instead of letting it get all swollen up seem to make the patient's function will be better and execute the plan by creating with: Patty pump people would read out all the way to push down her chest and he let it would create open up the alveoli to get people over dramatic pulmonary effusions by crating the sink on the lymphatic pump widget side of my chylomicrons on the lung tissue will with what we are doing it literally goes back to the foundations of what created a lot of modern medical sciences that without blood spiders and healing and that's true for orthopedic fractures is true for muscles tendon injuries we first started doing Bomer go back to that point on the trauma surgeon we were real sure that if we put bone marrow into a tendon that would make that was her fear with that we thought when we took Bomer Asper concentrate were real careful to make sure we we kept it in the in the osseous chart of the animals yet or you got it in the mentor factor was that there some really good studies published a bummer go back to the mid-90s there is a there was there was actually a really great study but here's a little they knew about what we're doing in Israel 1520 years ago there was a study on product complex possible tibial fractures which is a disaster if you have a tibial plateau the base you need if it's a complex fracture more than one particle shot six rights of Shatzer's fracture if you have a Shatzer six we used to call foobar that was our classification so we we with the Shatzer six what they did in Israel is they treated half of them with bone browser concentrate and half of them which is plating without moments were concentrated but interestingly because it was so early they added PRP to the bone restaurant concentrate thinking that it made work better and really all it does is dilute down so PRP the machine I have developed our tears I called them on sale define what you okay so the machine that we work with the machine I've been working with for for quite a while and have actually helped hopefully without taking real credit for anything but but knowing that that a been a significant part of innovation the development of their kit I'm actually patented the bone Ross Britt Catherine Catherine comes like it is my my design PRP is when you take whole blood and spin it down the machine to concentrate the growth factors get rid of some of the white cells and so you create was called platelet rich plasma write an platelet rich plasma is generated from the centrifugation of whole blood into the growth factors and platelets there needed to help get rid of inflammatory change a lot of times getting rid of the inflammatory change is the way to start the healing cycle inflammation gets in the way you put out the fire before you can grow new graphs right and so with inflammatory change if you turn the inflammation off ligaments tissue tendons heal faster with Bomer Esper concentrate what was it really understood as well in the 90s early 2000 and it is now hopefully is that bone marrow is still 97% whole blood so when we spend down bone marrow you're getting platelet rich plasma so your you are actually doing PRP yeah but you're doing PRP with stem cells yet so bone respite concentrate has the stem cells needed to help you heal and we know that those stem cells is when went on to hold your but while I was in school there wasn't such a thing as a musical social musical stem cell was named the music will stem cell 1995 by Dr. Arnie Case Western and Arnie Kaplan named a cell that previously in medicine what we do is we name cells based on the characteristics right so before it was musical stem cell was in a plastic undifferentiated employee potential adherent so that I liked it way better back in that day. I call it Mrs. a couple of them so well and and I doubt that there's terms equals some so most commonly know what they're talking about right so there's a CD marker a surface cell marker verse 600 different types of the cells based on their surface marker so we talked about was equal stem cells people think there's like one time no there someone that we don't really need help you heal the sum of the week need crucially to help you heal and we know the difference between these based on their CD markers we've actually quantitated what cells we want was told we don't want found a way to concentrate the cells want we do the spends so with bone marrow you're getting platelet rich plasma but you're getting the best platelet rich plasma because you're spending it from the most immature blood when you spend on whole blood you're getting PRP we are getting them no stem cells alright so let's clarify because it's a definition is really that what you're saying is that saying just stem cells doesn't mean just themselves how stem cells we have these mesenchymal stem cells which is the earliest of the stencil correct you guys have markers where you can determine the type of one that you know which ones do you need what was preferentially help you grow Cartledge what was professorship tendon what was preferentially grow fat right so fat stem cells that if you make if you make fat graph or stem so graph from fat those cells grow fat really well yeah we know what they don't grow really well's cartilage because there's a peptide called Sox nine this are secreted by the frustum so so when we quantitate stem cells I'm not interested in what those cells could become a me to say right now is this my pet. If you get a stem cell lecture in the first slide they show is this one so become these five types of cells in the differentiation and the building of the cells become these five is what makes somatic that's completely wrong that's true in the lab that's not how it works in the body what happens in the body is your set your body season injury it secretes cells starting with the humor putting stem cell which is the CD34 right so thrive for all the one second I got a good message where it says I can get a little stressed out I feel like I'm producing the wrong stem cells because I putting on weight change my stem cells to get rid of the adipose tissue and so sent there just go I got lost that CD something or other yeah you are way more so than I thought I would be as a orthopedist at the document bone bent may make straight actually know the medical school the running joke at time UNIX was the hardest residency to get into W had to become stupid right away take the smartest guys we need only to talk about when I mean I mean it when I say don't unlearn medicine right you the orthopedic resident was the hardest residency get to but you are expected to never even look at an EKG again if you walked into the surgery patient and you're like looking at their head or their EKG the attendings walking to go one the how you do know that you talk about this is Eric little people to sleep we have a certain dog like no dying right thing will similarly used to put my patients asleep so you feel like Dr. McKenna the CD six and 07 mesenchymal cells ready there's a joke that was that he found an orthopedist and the radiologist near going opposite direction of the code blue running away from the seed that what we used to say you know if you want if you have a dollar and you want to hide from a surgeon or from any kind of position there different places you put it right 100 from radiologist to tape to patient if you want to hide it if you want to hide it from orthopedic surgeon you put it in a book if you want to hide up a plastic surgeon we can hundred dollars from plastics are you going at a rabbit hole there went out on CD34 what were your talk was initiation healing right so with the CD34 it secretes a peptide for PG to PGE2 is is one of those keys and starting new vessel growth will the way to grow hair the way to have ED go away way to have stress urinary incontinence go away the way to have your wrinkles go away the way to have your fracture healed way to have your tendon remote you had me at wrinkles ED hair okay so so now we start out treating nonunion fractures right what we figure out pretty quick that if you put Bomer Asper concentrate it was it wasn't and is a great study published it was a limb salvage patient in Japan where 15 surgeries big proximal defect it's possible to be a and the the general surgeon was was livid at the orthopedic surgeons want to to put bone restaurant concentrate a fracture because he was proving that there was no vascularity to the way so to back door the orthopedic surgeon the supposed case report that a vascular surgeon does this arteriogram a lower extremity and it shows that there's literally no collateral flow around the fracture site is kid basically has a limb salvage frame on his leg this big proximal defect two years out multiple fascia economies nonmusical leg mask were really high needs needs annotation orthopedic surgeon is busy all the stuff about Mercer concentrate wants to inject bone marrow before he takes frame off eventually as a surgeon you become kind of emotionally connected to to your work right the guy does not want to cut the slide off the vascular surgeon try to prove needs come off he does arteriogram family Stone will it cut off so they have bone marrow injected in the fracture site at eight weeks they redo the arteriogram because the orthopedic surgeon the arterial was ordered by him but you start to see new bone kids have less pain from weight on lag you get new bone formation but they have this arteriogram set out to the shows no blood flow so they redo the arteriogram and there's all this collateral circulation on the fracture site so basically forever listening arteriogram is a study were it actually shows the arteries they put Diana vessel and shows up on x-ray and there is no blood flow going below over the fracture risers no.the die stops and there's a little bitty pattern this will trickle that I injected something into the bone not into the are not in the artery into the Perry steel sleeve the covering of the bone with the with the board there was no bone produces big bony defect there but Bomer us for concentrating their the way the bone roster concentrate work it didn't become bone which is what we thought what it does is it secretes the peptides and proteins necessary to bring new blood flow which allowed the bone to heal now there's a certain paragraphs that out there shows no collateral flow say that saying again that blood flow the rule of the artery is supreme the arteries and she still give him credit for that from the 1800s rule the arteries supreme lymphatics have veto power and that's a Dr. Graham from local states manipulation class, add on that if everything so swollen of blood flow can't get to it okay yeah so you guys injected this is the first time you saw that Ballmer answer because this can be a great segue will be go to the next half hour more we really do jump into the stem cell we got a little will try and keep it as it at a level that we can help people because I get a lot of back to let me make sure I'm being asked questions like it doesn't help with back yes to the health of the components were next on but on the great papers published read everyone says oh there's no literature published there's been 3500 papers published with my little Catherine the kit was designed for bummer aspirate 3500 papers published there's never been in toward report there's never been a tumor there's never been you can't reject your own bone marrow so this is the bone marrow aspirate injections you guys are doing this is the very beginning of Stansberry Reese is the only sell the US are allowed to cost himself you cannot you guys really literally were the first people playing around stems the trauma surgeon department: bone marrow yet not not knowing what we were doing we are using Bomer Asper concentrate for the fatty component of marrow that seem to help fracture so faster which is where microfracture surgery the knee all this comes in my mind from we would we do niece go there's an uncovered Carla Jerry would put a couple holes in the bone where in the bone the lesson bone marrow leak into the knee thinking that I hope the cards losing hills, microfracture doesn't work very well it creates a cartilaginous Good Cartilage but It Does Heal Something But My Thought Was When I Credit This Catheter If a Couple Drops of Bone Marrow Makes a Difference What Would What Would 60 ML Concentrated on the 45 That Was Where We Started with This During Joliet Harlan's Injuries at Work That's Where That Slow Beginning That's That's Only for Mia Do You Think I Do Think That Today's Bone Marrow in the Stem Cells Come from Bone Marrow Are Really Adapt to This Type of Healing to the Because That's Where We Release Our Red Blood Cells for Your Body Does Yeah Okay so This Is How Your Body Is Ready Right Right That You Were Not Were Inventing a New Way to Make Something He'll This Is How the Body Heals This Is Where Those You Know It This How God Does It Right He Sends the Cell There Is Secretes As Protein Vessel Grows You Get Your Butts by Tenant's Right This Is How It Works Already Is Just As We Get Older Or If You Get Your Lymphedema Swelling Only for the Lymphatic Flow Attacker Has Veto Power Is a Big Swollen Leg Give a Big Swollen Foot Good Books I Can't Get to It Right so It's All about Mobilizing Ankle Fracture and Also so That Blood Flow Can Get to It Because Official Swollen You Can't Put Any Extra Water in a Full Glass So New Water Can't Get to It That All Contaminated Dead Water Sits There yet to Pour the Glass out a Little Bit to Put Some New Healthy Water Back in That's How Bloodflow Work Which Is Why the Lymphedema and Lymphedema Is so Dangerous and Has It Has Absolute Control over Blood Flow to the to the Injured Tissue before We Dive Deep into Stem Cells Does PRP Work I Love You so Here's the Deal so Peer Peas like Boomer Light Okay so PRP Is Bone Marrow Announced Himself It's It's a Good Growth Component It's Great at It's a One-Time Shot Right so You When You Pop European Something You Get a One-Time Shot Growth Factors That Limits and Stops the Inflammatory Response from Cytokines You Undergo Tissue There's No Stem Cells You're Not Getting a Stem Cell Injection Which Is One of the Things He Pushes Me over the Edges Somewhere with I Went Got Stem Cells from My Blood Union You Got an Injection Visitor Was a Stem so That PRP Player Was Positive Now PRP Is Also a Bummer With Our Stem Cells in Bone Marrow so When You Say PRP Splenda If You Got It from Your Whole Blood It's Just Pure. If You Got Boom Roster Concentrate It's All the Best Components of European Stencils about That That Study Is Telling about So Here's How the Little so Even Though the They Publish Is Great Study Showing the Bonus Request Rate Help the Complex Factors Heal 50% Faster and All of Them Healed The Ones That Didn't Have Bone Marrow Not All of Them Healed and They Took Twice As Long Hill That Was Published 20 Years Ago Right with Bomer Asper Concentrate but Would They Knew so Little about Bomer Also Concentrate That They Spun down Whole Blood to In the Same Machine to Try to Give It More Volume Because We Thought the PRP Might Help the Bummer Work Better When in Actuality You're Already Getting PRP When You Spend Them Boomers of All We Were Doing Were Literally in a Study in Israel What They Were Just Alluding It's Just Laughing This Is Similar When You Say No You Think It's Them so You Got Blood You Are Talking about Fasting And I Had Some Friends and Maybe Overdone It on Adderall Little Bit like Three Days without Eating and Not Basing Radiology Headsets of Money I Was in Jail All Weekend and You Know There's a Great View We Talked about Intermittent Fasting There's a Great Study Published in Cell Metabolism Last Year That Showed That the That Are Correlated to Longevity in Mice And the the Mice Had the Longest Food Free Intervals Actually Increase Life Plaintiff Please Got a Hold of Our Dr. Wayne McKenna I Will Lose Track down the Same 10,000 This Is the Only 24 Hour Take Anywhere Platforms Dedicated to Food and Fun Clear Spoony Our Townhall.com, Where the Mother Report about to Be Released Atty. Gen. Bars As a Special Counsel's Russia Probe Leaves No Doubt That Moscow Did Try to Interfere in the 2016 US Electric Thanks to the Special Counsel's Thorough Investigation We Now Know That the Russian Operatives Who Perpetrated These Schemes Did Not Have the Cooperation of Pres. Trump or the Trunk Campaign or the Knowing Assistance of Any Other American for That Matter Bars As White House Cooperated Fully with the Special Counsel's Investigators And He Says the Evidence Gathered by Those Investigators Not Sufficient to Establish Obstruction of Justice White House Officials Had to Go over Each and Every Page of the 400 Page Molar Report the Trump White House Is Already Pronounced Total Exoneration for the President in the Russia Collusion Case but Attorneys and White House Staff Members Will Be Pouring over the Molar Documents Findings so They Can Craft an Official White House Response the President's Legal Team Also Is Planning to Release a Rebuttal of the Molar Report That's White House Correspondent Greg Clarkson Boeing Says It's Making Good Progress in a Software Fix for a Troubled Mac Series of 737s Following Highlights Engineers Technical Experts and Our Partners Were Comprehensively Testing the Software Make Sure That It Does the Job And They're Taking the Time To Get It Right Boeing CEO Dennis Wallenberg Max Gets Taken Out Of Service Just about Everywhere Pending the Software Update A Booming Job Market Means a Number of Americans Filing for Unemployment Now Dropped to the Lowest Level since November 1969 Retail Sales Surge Last Month up 1.6% On Wall Street Dow 53 Points Higher the S&P Is Two Points Lower the NASDAQ down 25 More of These Stories Said Townhall.com Now You Can Fly Anywhere in the World and Paid Discount Prices on Your Airline Tickets Flight to Date Alignment Harassment to Read or Anywhere Else You Want to Go and Pay A Lot Less Guarantee Quality International Travel Department Right Now Low-Cost Airlines 800 452 1075 800-452-1075 That's 800-452-1075 Got an Old Car You Can Donate It Whether It's Running or Not to the United Breast Cancer Foundation and Save the Life They'll Even Come and Pick It up for Free The United Breast Cancer Foundation Has Saved Hundreds of Women's Lives through Their Free or Low-Cost Breast Screening Exams but Now They Need Your Help The United Breast Cancer Foundation Wants to Save More Lives through Early Detection by Offering Women Free or Low-Cost Breast Screening Exams In Donating Your Old Car SUV or Truck Whether It's Running or Not Helps Pay for Them Plus You Get a Charitable Tax Deduction Help the United Breast Cancer Foundation Save Lives by Donating Your Old Car SUV or Truck Call Now for Free Pickup 800-245-0823 800-245-0823 800-245-0823 All Right Now That Number Again Is 800-245-0823 Never Forgotten Apparel Is More Than Just a Premium Women's and Men's Clothing Line It's a Movement to Remind Us to Wear American-Made and Serve Those Who Serve Us Our Heroes Never Forgotten Apparel Gives 20% of Their Total Sales to Nonprofits That Support Homeless Veterans and Off-Duty Firefighters and 50% to Individual Veterans and Firefighters in Need Nationwide Checkout Never Forgotten Apparel.com Use Promo Code Matt and ATT And Get 15% off Your Purchase Welcome Back It Is Now the Second Hour at Episode Number Seven I Got Kicked Back to Chimeric Rigor Jointly with Your Host Brown and We Also Have a Studio Today Dr. Wade McKenna Stem Cell Expert and Longtime Orthopedic Surgeon Well Everything We Start Firing up A Lot Of Brain Energy Going on on That Last Time I Started Hot and I'm Wearing My Tequila 512 Shirts Nicely Believe the Two People Sit in Front of Me Happened to Be Some Ownership in It and Big Fans of the Product and Enjoy Some Tequila Moms Will Have Some Tequila If I Want to Yes All Modifier Question but I Will Still Signal CBD Here to Regenerate My Ananda Mind into E.G. Nice Because I Think I Spent Some There with the Trying to Keep up with Dr. McKenna I Went through to Believe That I Write the Name That It It It but It Was Some System Select for I Was Looking See Who's behind Me but It But Literally We Been over 10,000 Cases in US Now so so Let Me Let Me Throw One out for You We Got a Message from Victoria That Says Can You Fix Bone on Bone Degenerative Discs so Here's the Short Answer in the You Know Me Enough Already by Now You Notice the In a Good Prospective Randomized Study of This Started with Just Pure P Because Again Bo Mastro Concentrate the Only Reason PRP Exists Is a Product Is Because We Couldn't Get Approval for Bone Marrow so We Were Spinning down Horseplay on the Equine Market You Could Sell PRP into People Pay More to Have Their Horse Injected My World Are Kid and That Horse Has Four Extremities and so Were Spinning on Whole Blood Created PRP While We're Waiting on the FDA to Approve Bone Marrow Whole Blood Is Exempt In Bone Marrow Was an and so Did Get the Validations on Bone Marrow and A Lot Of Pure P Was Created so There You Go so the Short Answer Is Enter Disco Injections Hemorrhoids Are Several Great Papers Are Republished and the Most Recent One at Two Years 92% of the Patients Had Inner Disco Injections on Degenerative Disc Disease And and I Would I Would Take It Even Step Farther and That in Our in Our Clinical Practice with over 300 Discs Now In That If You Have an Annular Tear Bring a Tear in the Covering of the Desk That Is a Primary Pain Generator It's a Bright Spot on the MRI Called Heisey Lesion Are High in Tinsel Science Is a Signal A Lot Of Radiologist Don't Now Failed to Mention That I Guess but If There's an Annular Tear High Intensity Signal within That within the Disc That Alone Is a Dramatic Pain Generator It Can Even Cause This Exact Same Symptoms As a Herniated Disc Would As Far As Lower Extremity Pain and Weakness Because the Nerve Crosses the Annular Tear in Your Tear Generate Substance P Generates the Cytokines Generates Exact Same Pain Response so Those Two Times of Radicular Pain Coming from the Back Leg and Hip Pain Radicular so That's the Old Folks Called Sciatica If It Can Be Pressure Because My Big Herniated Disc Neural Foraminal Stenosis Meeting the Canal Gets to Tie the Facets Your Baguette Hypertrophic Get Extra-Large They Were out so There's There's You Can Have Pressure Stenotic Pressure on Her Nerve Were Still Think It's Just Been Crushed That Causes Leg and Hip Pain and Back Pain Or You Can Have a Chemical Radiculopathy Created by a Tear in the Desk and It Feels the Same Patient until Difference One of Almost Everybody Else Is My Bulging Disc yet I Could Be There but but but Bulging to Start the Problem Because Here's What We Know Here's What's Already Published If Either MRIs and A Lot Of People Have No Back and Leg Pain A Lot Of Them Have Bulging This So How's It Happen How How Can Some People Smoking Just Hurts a Bit Was Bulging the Stone Right Now Is That If You Experience If You Have a Bulging Disc the Nonoperative Follow-Up At Two Years Is the Same As Opera Follow If You Don't Have Weakness If You Have Pain That You Can Tolerate and You Have Weakness in the Lower Extremity at Two Years Your Doom the Same As a People How Discectomy If You Don't Have Surgery What That's Published For Long Time so Were Not so If You Intrude a Free Fragment That Free Fragment Will Absorb Your Body Is Really Adept at Getting Rid of Items Extruded into the Canal and It Will Actually Absorb and and Get Rid of a Free Fragment As Long As Every Fragment Is Important so Much Pressure on the Nerve That It Decreases the Blood Supply from the Pressure Causes Weakness in the Lower Extremity from the Pressure the Nurse Stops Working You Have Leg Pain Your Little Foot Drop below Witnessing That Surgery You Have Weakness and You Start Paying What's Publish Now Is If We Inject That Disk the Annular Tear That Doesn't Go Away on Its Own Will Heal And Most of the Time 92% in a Study If the Annular Tear Heals The Back and Leg Pain Go Away 92 Persons 92% of the Playhouse That Had an Injection Didn't Go on to a Primary Fusion While Now Now Here's the Other Side of The Patients Had a Fusion at Five Years 30% of Them Had Two Surgeries So If You Have Fusion at One Level 30% Time of the Next Five Years Your Risk of Having a Second Surgery Either Refused at the Level above or below or Hardware Removal or Revision or You Get Extra Bone from the Fusion at the Re-Open up the Nerve Roots Have To Do in Reframing Autonomy Every Time You Do Surgery The Muscles of the Back Diablo So the Paravertebral Muscles the Muscle Mass so It Would When You Look at Some of Been for You It Will Look like Dinosaur Right That Little Thing the Bridge the Sticks up Familiar Back Check Is Called the Spinous Process The Muscles That Lay on Each Side of the Spinous Process Have To Be Moved Out Of the Way For You to Do a Back Surgery Weeks Make Fun of Spine Surgeons When I Was a Fellow in Trauma Because They Don't Have One Incision Is Midline Low Back Tonight We Had Learn All These Other Incisions and Sponsors in Certain Were More Online But What They Don't Learn That Trauma Surgeons Learn As We Make an Incision The Is Designed to Not Limit the Structure Function Blood Spire Nerve to the Muscle Were Moving In the Spine The Multiply the Small Muscle Each Side of That Bridge The Nerve and Vessel Come from Midland in the Back but Were Moving Away Is It When You Do an MRI of Someone's Back Is Set Back Surgery Initially The Muscles on Each Side of That Look like Filet Mignon That's Tenderloin Right That's the Backstrap Vassar Hunters Were Not Talking Tenderly Farewell Real Hungry so When You Move That Muscle out a Way And You Go Back and You Do an MRI That Back That Had Surgery and Other Fibers out And Having Pain Again And the Neurosurgeon Looks at the Films Goes While the Disc Looks Great the Nerve Roots Wide Open Usual Payments and That There Is No Reason for Your Backs on Well If You Look at the MRI Used To Look like Tenderloin Now Looks like Prime Bootleg like Strip Steak or or or Worse Just We Call White Muscle Syndrome Is Just Whole Thing Just Looks like Fatting a Filtration like Arby's Like Times like More like Crime-Ridden Right Is a Little Bit of Muscle Aches and Their Diagnosis Are You You Are Fasting for What You Are Armies Roy Rogers for My Generation Has To Follow-Up Question That She Was Asking How Many Injections Did That Take to Achieve the Most of Time Is One One Engine One Treatment One Injection We Do What We What We Do Is We Will You Be More Specific Rest of My My Problems Stem Cell Science As a Whole Is A Lot Of Times Patients Get in the Mix Were There Never Really Diagnosed and I Am a Firm Believer That You Can't Treat Something If You Didn't Diagnose It If I Don't Know What I'm Treating My Chances of Making It Go Away Are Pretty Slim and Entered and Unfortunately A Lot Of Stem Cell Injectors out There Don't Make the Effort to Actually Diagnose a Problem but to Get There Won't Inject Anything Well That's That That's Very Nonspecific Treatment in It, It Kinda Puts Your Your Results Risk If You Don't Know What You're Treating Because You Know What You Can Heal What You Can't Heal When You Do What We so What We Do We Were Doing Disc Injections I Want to Know That Was the Painter So There's an Old Test That Used To Be the Standard of Care before You Had a Fusion Now Because Fusions Are so Rampant in Our Country We've Gotten Away from More Specific Diagnosis on Making Sure T

Dr Daniel Guerra or VerEvMed and AB podcast provides the second part of his discussion concerning excitotoxic glutamate inducing aSMASE mediated neurodegeneration involving iron and the depletion of the glutathione-ROS- scavenging system in damaged and diseased oligodendrocytes. 25March2019B --- Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

In this podcast, Dr. Amit Garg discusses curcumin, its anti-inflammatory properties, and its usage as a natural health product. He describes a randomized-controlled trial he co-authored. In the study, oral curcumin was found to have no effect on biomarkers of organ injury and inflammatory response after abdominal aortic aneurysm repair. Dr. Amit Garg is a nephrologist and professor of medicine, epidemiology and biostatistics at Western University. The research article he co-authored is published in the Canadian Medical Association Journal. Full research article (open access): www.cmaj.ca/lookup/doi/10.1503/cmaj.180510 ----------------------------------- Subscribe to CMAJ Podcasts on Apple Podcasts, iTunes, Google Play, Stitcher, Overcast, Instacast, or your favourite aggregator. You can also follow us directly on our SoundCloud page or you can visit www.cmaj.ca/page/multimedia/podcasts.

Inflammation is the body's first self defence mechanism when fighting against infection and dying cells. Naturopath David Marston discusses the pros and cons of the inflammatory response within the body.

Ruslan Medzhitov (Yale School of Medicine) explains in this talk that the intricate connection between homeostasis and inflammation is rooted in underlying principles of control circuits.  He then describes these principles and their implications for human diseases. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 31606]

Ruslan Medzhitov (Yale School of Medicine) explains in this talk that the intricate connection between homeostasis and inflammation is rooted in underlying principles of control circuits.  He then describes these principles and their implications for human diseases. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 31606]

Nutritionist Alessandro Ferretti discusses data he has collected that may inform us as to the inflammatory response to diet and lifestyle, using markers such as blood glucose, heart rate variability and Alessandro's metric of "HRV/BG Index".

There is so much stirred up right now. People are searching for ways to be a part of the solution without being overwhelmed with stress, anxiety, anger and feelings of helplessness. There are inflammatory energies everywhere—news media, social media, and in private conversations. It is important to understand—both personally and globally—how these energies are affecting us and what we can do about them. Listen in as Sherryl Lin, a medical intuitive, shares an enlightening perspective.

Simon J. Finney, PhD, MBChB, editiorialist Arthur P. Wheeler, MD, FCCP, and CHEST Podcast Editor, D. Kyle Hogarth, MD, FCCP, discuss an article by Dr. Finney and others that reviews their research into modifying the traditional definition of the systemic inflammatory response syndrome (SIRS) following cardiac surgery. They found that they could improve the predictive value of SIRS criteria when the definition was adjusted to meeting three or more criteria or, most especially, fulfilling two or more of the criteria for at least six consecutive hours.

A deubiquitinase helps control the inflammatory response.

Gerd Burmester and Richard Lane discuss a potential new treatment for refractory rheumatoid arthritis.

Das biologische Geschlecht wird als ein Risikofaktor für die Entstehung und den Verlauf von septischen Zustandsbildern kontrovers diskutiert. In der hier vorgelegten Arbeit werden die Einflüsse genetischer Faktoren unter Berücksichtigung des biologischen Geschlechts und der Wirkung von Sexualsteroiden auf die entzündliche Antwort in einem Tiermodel untersucht. Hierzu wurde genotypisch verschieden Mausstämmen (A/J, C57BL6/J, DBA/2J, BALB/cJ und AKR/J) bakterielles Endotoxin (Lipopolysaccharid, LPS) intraperitoneal injiziert. Als Ausdruck der entzündlichen Antwort wurden Plasmaspiegel der Zytokine Tumor Nekrose Faktor alpha (TNF-a) und Interleukin 10 (IL-10) mittels ELSIA gemessen. Es zeigten sich deutliche geschlechtsspezifische Unterschiede in der LPS-induzierten entzündlichen Antwort von C57BL6/J-Mäusen (=B6), die hormonell bedingt zu sein scheinen. Der Vergleich mit A/J-Mäusen weist hier jedoch eine unterschiedliche Ausprägung und somit eine Abhängigkeit von genetischen Faktoren auf. Außerdem lässt sich die entzündliche Antwort durch Gabe von Sexual-Steroiden modulieren. Hierzu wurden Mäuse kastriert bzw. ovariektomiert und vor der Injektion von LPS mit 17-ß-Estrogen oder 5-a-Dihydrotestosteron behandelt. Männliche Tiere reagierten dabei allerdings deutlich besser auf diese Beeinflussung von außen. Darüber hinaus sind diese Effekte abhängig von genetischen Faktoren. Nach Änderung der hormonellen Bedingungen fanden sich bei den Männchen der einzelnen Stämme deutliche Unterschiede: Während sich einige Stämme z.T. unbeeinflusst, wie z.B. die IL-10 Plasmaspiegel von DBA/2J und BALB/c Mäusen nach Östrogen-Behandlung zeigten, fanden sich bei andere Stämme gar gegensätzliche Antworten, so z.B: die TNF-a Plasmaspiegel von A/J und B6 Mäusen nach Östrogen-Behandlung. Untersuchungen an der F1-Generation von A/J und B6 Mäusen zeigten, dass die beobachteten Effekte unabhängig von den Geschlechtschromosomen oder genetischem Imprinting zu sein scheinen. Die beobachteten Veränderungen durch hormonelle Manipulation wurden auch in ihrer Auswirkung auf den Verlauf nach einer letalen LPS-Injektion untersucht. Da Androgene allgemein als hauptsächlich verantwortlich für geschlechtsspezifische Unterschiede der entzündlichen Antwort eingeschätzt werden, wurde von der Verringerung der systemischen Androgenspiegel ein Überlebensvorteil erwartet. Um so interessanter war die Beobachtung, dass diesbezüglich lediglich A/J Mäuse nach chirurgischer Kastration vor den Auswirkungen von LPS geschützt waren. Dieser protektive Effekt könnte die Folge von sexual-steroid-abhängigen Änderungen in der Relation von pro- zu anti-inflammatorischer Komponente der entzündlichen Antwort sein. Es ist anzunehmen, dass dieser Schutz nur bei entsprechender genetischer Konstellation und wahrscheinlich in Abhängigkeit vom Verletzungsmechanismus zustande kommt. Östrogen-Behandlung von männlichen A/J and B6 Mäusen brachte kein verbessertes Überleben nach Endotoxinschock. Die vorgelegten Daten erlauben die Schlussfolgerung, dass biologisches Geschlecht und individuelle genetische Ausstattung gemeinsam einen messbaren Einfluss auf die LPS-induzierte entzündliche Antwort haben. Könnte man diese Ergebnisse auf Menschen übertragen, so ließe sich hieraus eine Erklärung für gegensätzliche Beobachtungen bei geschlechtsspezifischen Unterschieden in klinischen Studien ableiten. Genetische Marker könnten helfen, die Einflüsse des biologischen Geschlechts auf die entzündliche Antwort klinisch besser untersuchen zu können. Die Suche nach solchen Markern sollte in Zukunft intensiviert werden, da ihnen auch eine große Bedeutung für das Design von Laborexperimenten und klinischen Studien zukommt, aus denen sich dann eventuell sogar therapeutische Ansätzen zur Milderung der sekundären Effekte von Verletzungen ableiten lassen.