Podcasts about gentech

The reception to our recent post on Code Reviews has been strong. Catch up!Amid a maelstrom of discussion on whether or not AI is killing SaaS, one of the top publicly listed SaaS companies in the world has just reported record revenues, clearing well over $1.1B in ARR for the first time with a 28% margin. As we comment on the pod, Aaron Levie is the rare public company CEO equally at home in both worlds of Silicon Valley and Wall Street/Main Street, by day helping 70% of the Fortune 500 with their Enterprise Advanced Suite, and yet by night is often found in the basements of early startups and tweeting viral insights about the future of agents.Now that both Cursor, Cloudflare, Perplexity, Anthropic and more have made Filesystems and Sandboxes and various forms of “Just Give the Agent a Box” cool (not just cool; it is now one of the single hottest areas in AI infrastructure growing 100% MoM), we find it a delightfully appropriate time to do the episode with the OG CEO who has been giving humans and computers Boxes since he was a college dropout pitching VCs at a Michael Arrington house party.Enjoy our special pod, with fan favorite returning guest/guest cohost Jeff Huber!Note: We didn't directly discuss the AI vs SaaS debate - Aaron has done many, many, many other podcasts on that, and you should read his definitive essay on it. Most commentators do not understand SaaS businesses because they have never scaled one themselves, and deeply reflected on what the true value proposition of SaaS is.We also discuss Your Company is a Filesystem:We also shoutout CTO Ben Kus' and the AI team, who talked about the technical architecture and will return for AIE WF 2026.Full Video EpisodeTimestamps* 00:00 Adapting Work for Agents* 01:29 Why Every Agent Needs a Box* 04:38 Agent Governance and Identity* 11:28 Why Coding Agents Took Off First* 21:42 Context Engineering and Search Limits* 31:29 Inside Agent Evals* 33:23 Industries and Datasets* 35:22 Building the Agent Team* 38:50 Read Write Agent Workflows* 41:54 Docs Graphs and Founder Mode* 55:38 Token FOMO Culture* 56:31 Production Function Secrets* 01:01:08 Film Roots to Box* 01:03:38 AI Future of Movies* 01:06:47 Media DevRel and EngineeringTranscriptAdapting Work for AgentsAaron Levie: Like you don't write code, you talk to an agent and it goes and does it for you, and you may be at best review it. That's even probably like, like largely not even what you're doing. What's happening is we are changing our work to make the agents effective. In that model, the agent didn't really adapt to how we work.We basically adapted to how the agent works. All of the economy has to go through that exact same evolution. Right now, it's a huge asset and an advantage for the teams that do it early and that are kinda wired into doing this ‘cause you'll see compounding returns. But that's just gonna take a while for most companies to actually go and get this deployed.swyx: Welcome to the Lane Space Pod. We're back in the chroma studio with uh, chroma, CEO, Jeff Hoover. Welcome returning guest now guest host.Aaron Levie: It's a pleasure. Wow. How'd you get upgraded to, uh, to that?swyx: Because he's like the perfect guy to be guest those for you.Aaron Levie: That makes sense actually, for We love context. We, we both really love context le we really do.We really do.swyx: Uh, and we're here with, uh, Aaron Levy. Welcome.Aaron Levie: Thank you. Good to, uh, good to be [00:01:00] here.swyx: Uh, yeah. So we've all met offline and like chatted a little bit, but like, it's always nice to get these things in person and conversation. Yeah. You just started off with so much energy. You're, you're super excited about agents.I loveAaron Levie: agents.swyx: Yeah. Open claw. Just got by, got bought by OpenAI. No, not bought, but you know, you know what I mean?Aaron Levie: Some, some, you know, acquihire. Executiveswyx: hire.Aaron Levie: Executive hire. Okay. Executive hire. Say,swyx: hey, that's my term. Okay. Um, what are you pounding the table on on agents? You have so many insightful tweets.Why Every Agent Needs a BoxAaron Levie: Well, the thing that, that we get super excited by that I think is probably, you know, should be relatively obvious is we've, we've built a platform to help enterprises manage their files and their, their corporate files and the permissions of who has access to those files and the sharing collaboration of those files.All of those files contain really, really important information for the enterprise. It might have your contracts, it might have your research materials, it might have marketing information, it might have your memos. All that data obviously has, you know, predominantly been used by humans. [00:02:00] But there's been one really interesting problem, which is that, you know, humans only really work with their files during an active engagement with them, and they kind of go away and you don't really see them for a long time.And all of a sudden, uh, with the power of AI and AI agents, all of that data becomes extremely relevant as this ongoing source of, of answers to new questions of data that will transform into, into something else that, that produces value in your organization. It, it contains the answer to the new employee that's onboarding, that needs to ramp up on a project.Um, it contains the answer to the right thing to sell a customer when you're having a conversation to them, with them contains the roadmap information that's gonna produce the next feature. So all that data. That previously we've been just sort of storing and, and you know, occasionally forgetting about, ‘cause we're only working on the new active stuff.All of that information becomes valuable to the enterprise and it's gonna become extremely valuable to end users because now they can have agents go find what they're looking for and produce new, new [00:03:00] value and new data on that information. And it's gonna become incredibly valuable to agents because agents can roam around and do a bunch of work and they're gonna need access to that data as well.And um, and you know, sometimes that will be an agent that is sort of working on behalf of, of, of you and, and effectively as you as and, and they are kind of accessing all of the same information that you have access to and, and operating as you in the system. And then sometimes there's gonna be agents that are just.Effectively autonomous and kind of run on their own and, and you're gonna collaborate and work with them kind of like you did another person. Open Claw being the most recent and maybe first real sort of, you know, kind of, you know, up updating everybody's, you know, views of this landscape version of, of what that could look like, which is, okay, I have an agent.It's on its own system, it's on its own computer, it has access to its own tools. I probably don't give it access to my entire life. I probably communicate with it like I would an assistant or a colleague and then it, it sort of has this sandbox environment. So all of that has massive implications for a platform that manage that [00:04:00] enterprise data.We think it's gonna just transform how we work with all of the enterprise content that we work with, and we just have to make sure we're building the right platform to support that.swyx: The sort of shorthand I put it is as people build agents, everybody's just realizing that every agent needs a box. Yes.And it's nice to be called box and just give everyone a box.Aaron Levie: Hey, I if I, you know, if we can make that go viral, uh, like I, I think that that terminology, I, that's theswyx: tagline. Every agentAaron Levie: needs a box. Every agent needs a box. If we can make that the headline of this, I'm fine with this. And that's the billboard I wanna like Yeah, exactly.Every agent needs a box. Um, I like it. Can we ship this? Like,swyx: okay, let's do it. Yeah.Aaron Levie: Uh, my work here is done and I got the value I needed outta this podcast Drinks.swyx: Yeah.Agent Governance and IdentityAaron Levie: But, but, um, but, but, you know, so the thing that we, we kind of think about is, um, is, you know, whether you think the number 10 x or a hundred x or whatever the number is, we're gonna have some order of magnitude more agents than people.That's inevitable. It has to happen. So then the question is, what is the infrastructure that's needed to make all those agents effective in the enterprise? Make sure that they are well governed. Make sure they're only doing [00:05:00] safe things on your information. Make sure that they're not getting exposed. The data that they shouldn't have access to.There's gonna be just incredibly spectacularly crazy security incidents that will happen with agents because you'll prompt, inject an agent and sort of find your way through the CRM system and pull out data that you shouldn't have access to. Oh, weJeff Huber: have God,Aaron Levie: right? I mean, that's just gonna happen all over the place, right?So, so then the thing is, is how do you make sure you have the right security, the permissions, the access controls, the data governance. Um, we actually don't yet exactly know in many cases how we're gonna regulate some of these agents, right? If you think about an agent in financial services, does it have the exact same financial sort of, uh, requirements that a human did?Or is it, is the risk fully on the human that was interacting or created the agent? All open questions, but no matter what, there's gonna need to be a layer that manages the, the data they have access to, the workflows that they're involved in, pulling up data from multiple systems. This is the new infrastructure opportunity in the era of agents.swyx: You have a piece on agent identities, [00:06:00] which I think was today, um, which I think a lot of breaking news, the security, security people are talking about, right? Like you basically, I, I always think of this as like, well you need the human you and then there you need the agent. YouAaron Levie: Yes.swyx: And uh, well, I don't know if it's that simple, but is box going to have an opinion on that or you're just gonna be like, well we're just the sort of the, the source layer.Yeah. Let's Okta of zero handle that.Aaron Levie: I think we're gonna have an opinion and we will work with generally wherever the contours of the market end up. Um, and the reason that we're gonna have an opinion more than other topics probably is because one of the biggest use cases for why your agent might need it, an identity is for file system access.So thus we have to kind of think about this pretty deeply. And I think, uh, unless you're like in our world thinking about this particular problem all day long, it might be, you know, like, why is this such a big deal? And the reason why it's a really big deal is because sometimes sort of say, well just give the agent an, an account on the system and it just treats, treat it like every other type of user on the system.The [00:07:00] problem is, is that I as Aaron don't really have any responsibility over anybody else's box account in our organization. I can't see the box account of any other employee that I work with. I am not liable for anything that they do. And they have, I have, I have, you know, strict privacy requirements on everything that they're able to, you know, that, that, that they work on.Agents don't have that, you know, don't have those properties. The person who creates the agent probably is gonna, for the foreseeable future, take on a lot of the liability of what that agent does. That agent doesn't deserve any privacy because, because it's, you know, it can't fully be autonomously operated and it doesn't have any legal, you know, kind of, you know, responsibility.So thus you can't just be like, oh, well I'll just create a bunch of accounts and then I'll, I'll kind of work with that agent and I'll talk to it occasionally. Like you need oversight of that. And so then the question is, how do you have a world where the agent, sometimes you have oversight of, but what if that agent goes and works with other people?That person over there is collaborating with the agent on something you shouldn't have [00:08:00] access to what they're doing. So we have all of these new boundaries that we're gonna have to figure out of, of, you know, it's really, really easy. So far we've been in, in easy mode. We've hit the easy button with ai, which is the agent just is you.And when you're in quad code and you're in cursor, and you're in Codex, you're just, the agent is you. You're offing into your services. It can do everything you can do. That's the easy mode. The hard mode is agents are kind of running on their own. People check in with them occasionally, they're doing things autonomously.How do you give them access to resources in the enterprise and not dramatically increased the security risk and the risk that you might expose the wrong thing to somebody. These are all the new problems that we have to get solved. I like the identity layer and, and identity vendors as being a solution to that, but we'll, we'll need some opinions as well because so many of the use cases are these collaborative file system use cases, which is how do I give it an agent, a subset of my data?Give it its own workspace as well. ‘cause it's gonna need to store off its own information that would be relevant for it. And how do I have the right oversight into that? [00:09:00]Jeff Huber: One thing, which, um, I think is kind interesting, think about is that you know, how humans work, right? Like I may not also just like give you access to the whole file.I might like sit next to you and like scroll to this like one part of the file and just show you that like one part and like, you know,swyx: partial file access.Jeff Huber: I'm just saying I think like our, like RA does seem to be dead, right? Like you wanna say something is dead uhhuh probably RA is dead. And uh, like the auth story to me seems like incredibly unsolved and unaddressed by like the existing state of like AI vendors.ButAaron Levie: yeah, I think, um, we're, I mean you're taking obviously really to level limit that we probably need to solve for. Yeah. And we built an access control system that was, was kind of like, you know, its own little world for, for a long time. And um, and the idea was this, it's a many to many collaboration system where I can give you any part of the file system.And it's a waterfall model. So if I give you higher up in the, in the, in the system, you get everything below. And that, that kind of created immense flexibility because I can kind of point you to any layer in the, in the tree, but then you're gonna get access to everything kind of below it. And that [00:10:00] mostly is, is working in this, in this world.But you do have to manage this issue, which is how do I create an agent that has access to some of my stuff and somebody else's stuff as well. Mm-hmm. And which parts do I get to look at as the creator of the agent? And, and these are just brand new problems? Yeah. Crazy. And humans, when there was a human there that was really easy to do.Like, like if the three of us were all sharing, there'd be a Venn diagram where we'd have an overlapping set of things we've shared, but then we'd have our own ways that we shared with each other. In an agent world, somebody needs to take responsibility for what that agent has access to and what they're working on.These are like the, some of the most probably, you know, boring problems for 98% of people on, on the internet, but they will be the problems that are the difference between can you actually have autonomous agents in an enterprise contextswyx: Yeah.Aaron Levie: That are not leaking your data constantly.swyx: No. Like, I mean, you know, I run a very, very small company for my conference and like we already have data sensitivity issues.Yes. And some of my team members cannot see Yes. Uh, the others and like, I can't imagine what it's like to run a Fortune 500 and like, you have to [00:11:00] worry about this. I'm just kinda curious, like you, you talked to a lot like, like 70, 80% of your cus uh, of the Fortune 500, your customers.Aaron Levie: Yep. 67%. Just so we're being verySEswyx: precise.So Yeah. I'm notAaron Levie: Okay. Okay.swyx: Something I'm rounding up. Yes. Round up. I'm projecting to, forAaron Levie: the government.swyx: I'm projecting to the end of the year.Aaron Levie: Okay.swyx: There you go.Aaron Levie: You do make it sound like, like we, we, well we've gotta be on this. Like we're, we're taking way too long to get to 80%. Well,swyx: no, I mean, so like. How are they approaching it?Right? Because you're, you don't have a, you don't have a final answer yet.Why Coding Agents Took Off FirstAaron Levie: Well, okay, so, so this is actually, this is the stark reality that like, unfortunately is the kinda like pouring the water on the party a little bit.swyx: Yes.Aaron Levie: We all in Silicon Valley are like, have the absolute best conditions possible for AI ever.And I think we all saw the dke, you know, kind of Dario podcast and this idea of AI coding. Why is that taken off? And, and we're not yet fully seeing it everywhere else. Well, look, if you just like enumerated the list of properties that AI coding has and then compared it to other [00:12:00] knowledge work, let's just, let's just go through a few of them.Generally speaking, you bring on a new engineer, they have access to a large swath of the code base. Like, there's like very, like you, just, like new engineer comes on, they can just go and find the, the, the stuff that they, they need to work with. It's a fully text in text out. Medium. It's only, it's just gonna be text at the end of the day.So it's like really great from a, from just a, uh, you know, kinda what the agent can work with. Obviously the models are super trained on that dataset. The labs themselves have a really strong, kind of self-reinforcing positive flywheel of why they need to do, you know, agent coding deeply. So then you get just better tooling, better services.The actual developers of the AI are daily users of the, of the thing that they're we're working on versus like the, you know, probably there's only like seven Claude Cowork legal plugin users at Anthropic any given day, but there's like a couple thousand Claude code and you know, users every single day.So just like, think about which one are they getting more feedback on. All day long. So you just go through this list. You have a, you know, everybody who's a [00:13:00] developer by definition is technical so they can go install the latest thing. We're all generally online, or at least, you know, kinda the weird ones are, and we're all talking to each other, sharing best practices, like that's like already eight differences.Versus the rest of the economy. Every other part of the economy has like, like six to seven headwinds relative to that list. You go into a company, you're a banker in financial services, you have access to like a, a tiny little subset of the total data that's gonna be relevant to do your job. And you're have to start to go and talk to a bunch of people to get the right data to do your job because Sally didn't add you to that deal room, you know, folder.And that that, you know, the information is actually in a completely different organization that you now have to go in and, and sort of run into. And it's like you have this endless list of access controls and security. As, as you talked about, you have a medium, which is not, it's not just text, right? You have, you have a zoom call that, that you're getting all of the requirements from the customer.You have a lot of in-person conversations and you're doing in-person sales and like how do you ever [00:14:00] digitize all of that information? Um, you know, I think a lot of people got upset with this idea that the code base has all the context, um, that I don't know if you follow, you know, did you follow some of that conversation that that went viral?Is like, you know, it's not that simple that, that the code base doesn't have all the knowledge, but like it's a lot, you're a lot better off than you are with other areas of knowledge work. Like you, we like, we like have documentation practices, you write specifications. Those things don't exist for like 80% of work that happens in the enterprise.That's the divide that we have, which is, which is AI coding has, has just fully, you know, where we've reached escape velocity of how powerful this stuff is, and then we're gonna have to find a way to bring that same energy and momentum, but to all these other areas of knowledge work. Where the tools aren't there, the data's not set up to be there.The access controls don't make it that easy. The context engineering is an incredibly hard problem because again, you have access control challenges, you have different data formats. You have end users that are gonna need to kind of be kind of trained through this as opposed to their adopting [00:15:00] these tools in their free time.That's where the Fortune 500 is. And so we, I think, you know, have to be prepared as an industry where we are gonna be on a multi-year march to, to be able to bring agents to the enterprise for these workflows. And I think probably the, the thing that we've learned most in coding that, that the rest of the world is not yet, I think ready for, I mean, we're, they'll, they'll have to be ready for it because it's just gonna inevitably happen is I think in coding.What, what's interesting is if you think about the practice of coding today versus two years ago. It's probably the most changed workflow in maybe the history of time from the amount of time it's changed, right? Yeah. Like, like has any, has any workflow in the entire economy changed that quickly in terms of the amount of change?I just, you know, at least in any knowledge worker workflow, there's like very rarely been an event where one piece of technology and work practice has so fundamentally, you know, changed, changed what you do. Like you don't write code, you talk to an agent and it goes and [00:16:00] does it for you, and you may be at best review it.And even that's even probably like, like largely not even what you're doing. What's happening is we are changing our work to make the agents effective. In that model, the agent didn't really adapt to how we work. We basically adapted to how the agent works. Mm-hmm. All of the economy has to go through that exact same evolution.The rest of the economy is gonna have to update its workflows to make agents effective. And to give agents the context that they need and to actually figure out what kind of prompting works and to figure out how do you ensure that the agent has the right access to information to be able to execute on its work.I, you know, this is not the panacea that people were hoping for, of the agent drops in, just automates your life. Like you have to basically re-engineer your workflow to get the most out of agents and, uh, and that, that's just gonna take, you know, multiple years across the economy. Right now it's a huge asset and an advantage for the teams that do it early and that are kinda wired into doing this.‘cause [00:17:00] you'll see compounding returns, but that's just gonna take a while for most companies to actually go and get this deployed.swyx: I love, I love pushing back. I think that. That is what a lot of technology consultants love to hear this sort of thing, right? Yeah, yeah, yeah. First to, to embrace the ai. Yes. To get to the promised land, you must pay me so much money to a hundred percent to adopt the prescribed way of, uh, conforming to the agents.Yes. And I worry that you will be eclipsed by someone else who says, no, come as you are.Aaron Levie: Yeah.swyx: And we'll meet you where you are.Aaron Levie: And, and, and and what was the thing that went viral a week ago? OpenAI probably, uh, is hiring F Dees. Yeah. Uh, to go into the enterprise. Yeah. Yeah. And then philanthropic is embedded at Goldman Sachs.Yeah. So if the labs are having to do this, if, if the labs have decided that they need to hire FDE and professional services, then I think that's a pretty clear indication that this, there's no easy mode of workflow transformation. Yeah. Yeah. So, so to your point, I think actually this is a market opportunity for, you know, new professional services and consulting [00:18:00] firms that are like Agent Build and they, and they kind of, you know, go into organizations and they figure out how to re-engineer your workflows to make them more agent ready and get your data into the right format and, you know, reconstruct your business process.So you're, you're not doing most of the work. You're telling agents how to do the work and then you're reviewing it. But I haven't seen the thing that can just drop in and, and kinda let you not go through those changes.swyx: I don't know how that kind of sales pitch goes over. Yeah. You know, you're, you're saying things like, well, in my sort of nice beautiful walled garden, here's, there's, uh, because here's this, here's this beautiful box account that has everything.Yes. And I'm like, well, most, most real life is extremely messy. Sure. And like, poorly named and there duplicate this outdated s**tAaron Levie: a hundred percent. And so No, no, a hundred percent. And so this is actually No. So, so this is, I mean, we agree that, that getting to the beautiful garden is gonna be tough.swyx: Yeah.Aaron Levie: There's also the other end of the spectrum where I, I just like, it's a technical impossibility to solve. The agent is, is truly cannot get enough context to make the right decision in, in the, in the incredibly messy land. Like there's [00:19:00] no a GI that will solve that. So, so we're gonna have to kind of land in somewhere in between, which is like we all collectively get better at.Documentation practices and, and having authoritative relatively up-to-date information and putting it in the right place like agents will, will certainly cause us to be much better organized around how we work with our information, simply because the severity of the agent pulling the wrong data will be too high and the productivity gain of that you'll miss out on by not doing this will be too high as well, that you, that your competition will just do it and they'll just have higher velocity.So, uh, and, and we, we see this a lot firsthand. So we, we build a series of agents internally that they can kind of have access to your full box account and go off and you give it a task and it can go find whatever information you're looking for and work with. And, you know, thank God for the model progress, but like, if, if you gave that task to an agent.Nine months ago, you're just gonna get lots of bogus answers because it's gonna, it's gonna say, Hey, here's, here are fi [00:20:00] five, you know, documents that all kind of smell like the right thing. And I'm gonna, but I, but you're, you're putting me on the clock. ‘cause my assistant prompt says like, you know, be pretty smart, but also try and respond to the user and it's gonna respond.And it's like, ah, it got the wrong document. And then you do that once or twice as a knowledge worker and you're just neverswyx: again,Aaron Levie: never again. You're just like done with the system.swyx: Yeah. It doesn't work.Aaron Levie: It doesn't work. And so, you know, Opus four six and Gemini three one Pro and you know, whatever the latest five 3G BT will be, like, those things are getting better and better and it's using better judgment.And this sort of like the, all of these updates to the agentic tool and search systems are, are, we're seeing, we're seeing very real progress where the agent. Kind of can, can almost smell some things a little bit fishy when it's getting, you know, we, we have this process where we, we have it go fan out, do a bunch of searches, pull up a bunch of data, and then it has to sort of do its own ranking of, you know, what are the right documents that, that it should be working with.And again, like, you know, the intelligence level of a model six months ago, [00:21:00] it'd be just throwing a dart at like, I'm just, I'm gonna grab these seven files and I, I pray, I hope that that's the right answer. And something like an opus first four five, and now four six is like, oh, it's like, no, that one doesn't seem right relative to this question because I'm seeing some signal that is making that, you know, that's contradicting the document where it would normally be in the tree and who should have access.Like it's doing all of that kind of work for you. But like, it still doesn't work if you just have a total wasteland of data. Like, it's just not, it's just not possible. Partly ‘cause a human wouldn't even be able to do it. So basically if a, if a really, really smart human. Could not do that task in five or 10 minutes for a search retrieval type task.Look, you know, your agent's not gonna be able to do it any better. You see this all day long. SoContext Engineering and Search Limitsswyx: this touches on a thing that just passionate about it was just context engineering. I, I'm just gonna let you ramble or riff on, on context engineering. If, if, if there's anything like he, he did really good work on context fraud, which has really taken over as like the term that people use and the referenceAaron Levie: a hundred percent.We, we all we think about is, is the context rob problem. [00:22:00]Jeff Huber: Yeah, there's certainly a lot of like ranking considerations. Gentech surgery think is incredibly promising. Um, yeah, I was trying to generate a question though. I think I have a question right now. Swyx.Aaron Levie: Yeah, no, but like, like I think there was this moment, um, you know, like, I don't know, two years ago before, before we knew like where the, the gotchas were gonna be in ai and I think someone was like, was like, well, infinite context windows will just solve all of these problems and ‘cause you'll just, you'll just give the context window like all the data and.It's just like, okay, I mean, maybe in 2035, like this is a viable solution. First of all, it, it would just, it would just simply cost too much. Like we just can't give the model like the 5,000 documents that might be relevant and it's gonna read them all. And I've seen enough to, to start believing in crazy stuff.So like, I'm willing to just say, sure. Like in, in 10 years from now,swyx: never say, never, never.Aaron Levie: In, in 10 years from now, we'll have infinite context windows at, at a thousandth of the price of today. Like, let's just like believe that that's possible, but Right. We're in reality today. So today we have a context engineering [00:23:00] problem, which is, I got, I got, you know, 200,000 tokens that I can work with, or prob, I don't even know what the latest graph is before, like massive degradation.16. Okay. I have 60,000 tokens that I get to work with where I'm gonna get accurate information. That's not a lot of tokens for a corpus of 10 million documents that a knowledge worker might have across all of the teams and all the projects and all the people they work with. I have, I have 10 million documents.Which, you know, maybe is times five pages per document or something like that. I'm at 50 million pages of information and I have 60,000 tokens. Like, holy s**t. Yeah. This is like, how do I bridge the 50 million pages of information with, you know, the couple hundred that I get to work with in that, in that token window.Yeah. This is like, this is like such an interesting problem and that's why actually so much work is actually like, just like search systems and the databases and that layer has to just get so locked in, but models getting better and importantly [00:24:00] knowing when they've done a search, they found the wrong thing, they go back, they check their work, they, they find a way to balance sort of appeasing the user versus double checking.We have this one, we have this one test case where we ask the agent to go find. 10 pieces of information.swyx: Is this the complex work eval?Aaron Levie: Uh, this is actually not in the eval. This is, this is sort of just like we have a bunch of different, we have a bunch of internal benchmark kind of scenarios. Every time we, we update our agent, we have one, which is, I ask it to find all of our office addresses, and I give it the list of 10 offices that we have.And there's not one document that has this, maybe there should be, that would be a great example of the kind of thing that like maybe over time companies start to, you know, have these sort of like, what are the canonical, you know, kind of key areas of knowledge that we need to have. We don't seem to have this one document that says, here are all of our offices.We have a bunch of documents that have like, here's the New York office and whatever. So you task this agent and you, you get, you say, I need the addresses for these 10 offices. Okay. And by the way, if you do this on any, you know, [00:25:00] public chat model, the same outcome is gonna happen. But for a different kind of query, you give it, you say, I need these 10 addresses.How many times should the agent go and do its search before it decides whether or not, there's just no answer to this question. Often, and especially the, the, let's say lower tier models, it'll come back and it'll give you six of the 10 addresses. And it'll, and I'll just say I couldn't find the otherswyx: four.It, it doesn't know what It doesn't know. ItAaron Levie: doesn't know what It doesn't know. Yeah. So the model is just like, like when should it stop? When should it stop doing? Like should it, should it do that task for literally an hour and just keep cranking through? Maybe I actually made up an office location and it doesn't know that I made it up and I didn't even know that I made it up.Like, should it just keep, re should it read every single file in your entire box account until it, until it should exhaust every single piece of information.swyx: Expensive.Aaron Levie: These are the new problems that we have. So, you know, something like, let's say a new opus model is sort of like, okay, I'm gonna try these types of queries.I didn't get exactly what I wanted. I'm gonna try again. I'm gonna, at [00:26:00] some point I'm gonna stop searching. ‘cause I've determined that that no amount of searching is gonna solve this problem. I'm just not able to do it. And that judgment is like a really new thing that the model needs to be able to have.It's like, when should it give up on a task? ‘cause, ‘cause you just don't, it's a can't find the thing. That's the real world of knowledge, work problems. And this is the stuff that the coding agents don't have to deal with. Because they, it just doesn't like, like you're not usually asking it about, you're, you're always creating net new information coming right outta the model for the most part.Obviously it has to know about your code base and your specs and your documentation, but, but when you deploy an agent on all of your data that now you have all of these new problems that you're dealing withJeff Huber: our, uh, follow follow-up research to context ride is actually on a genetic search. Ah. Um, and we've like right, sort of stress tested like frontier models and their ability to search.Um, and they're not actually that good at searching. Right. Uh, so you're sort of highlighting this like explore, exploit.swyx: You're just say, Debbie, Donna say everything doesn't work. Like,Aaron Levie: well,Jeff Huber: somebody has to be,Aaron Levie: um, can I just throw out one more thing? Yeah. That is different from coding and, and the rest [00:27:00] of the knowledge work that I, I failed to mention.So one other kind of key point is, is that, you know, at the end of the day. Whether you believe we're in a slop apocalypse or, or whatever. At the end of the day, if you, if you build a working product at the end of, if you, if you've built a working solution that is ultimately what the customer is paying for, like whether I have a lot of slop, a little slop or whatever, I'm sure there's lots of code bases we could go into in enterprise software companies where it's like just crazy slop that humans did over a 20 year period, but the end customer just gets this little interface.They can, they can type into it, it does its thing. Knowledge work, uh, doesn't have that property. If I have an AI model, go generate a contract and I generate a contract 20 times and, you know, all 20 times it's just 3% different and like that I, that, that kind of lop introduces all new kinds of risk for my organization that the code version of that LOP didn't, didn't introduce.These are, and so like, so how do you constrain these models to just the part that you want [00:28:00] them to work on and just do the thing that you want them to do? And, and, you know, in engineering, we don't, you can't be disbarred as an engineer, but you could be disbarred as a lawyer. Like you can do the wrong medical thing In healthcare, you, there's no, there's no equivalent to that of engineering.Like, doswyx: you want there to be, because I've considered softwareJeff Huber: engineer. What's that? Civil engineering there is, right? NotAaron Levie: software civil engineer. Sure. Oh yeah, for sure. But like in any of our companies, you like, you know, you'll be forgiven if you took down the site and, and we, we will do a rollback and you'll, you'll be in a meeting, but you have not been disbarred as an engineer.We don't, we don't change your, you know, your computer science, uh, blameJeff Huber: degree, this postmortem.Aaron Levie: Yeah, exactly. Exactly. So, so, uh, now maybe we collectively as an industry need to figure out like, what are you liable for? Not legally, but like in a, in a management sense, uh, of these agents. All sorts of interesting problems that, that, that, uh, that have to come out.But in knowledge work, that's the real hostile environments that we're operating in. Hmm.swyx: I do think like, uh, a lot of the last year's, 2025 story was the rise of coding agents and I think [00:29:00] 2026 story is definitely knowledge work agents. Yes. A hundredAaron Levie: percent.swyx: Right. Like that would, and I think open claw core work are just the beginning.Yes. Like it's, the next one's gonna just gonna be absolute craziness.Aaron Levie: It it is. And, and, uh, and it's gonna be, I mean, again, like this is gonna be this, this wave where we, we are gonna try and bring as many of the practices from coding because that, that will clearly be the forefront, which is tell an agent to go do something and has an access to a set of resources.You need to be responsible for reviewing it at the end of the process. That to me is the, is the kind of template that I just think goes across knowledge, work and odd. Cowork is a great example. Open Closet's a great example. You can kind of, sort of see what Codex could become over time. These are some, some really interesting kind of platforms that are emerging.swyx: Okay. Um, I wanted to, we touched on evals a little bit. You had, you had the report that you're gonna go bring up and then I was gonna go into like, uh, boxes, evals, but uh, go ahead. Talk about your genetic search thing.Jeff Huber: Yeah. Mostly I think kinda a few of the insights. It's like number one frontier model is not good at search.Humans have this [00:30:00] natural explore, exploit trade off where we kinda understand like when to stop doing something. Also, humans are pretty good at like forgetting actually, and like pruning their own context, whereas agents are not, and actually an agent in their kind of context history, if they knew something was bad and they even, you could see in the trace the reason you trace, Hey, that probably wasn't a good idea.If it's still in the trace, still in the context, they'll still do it again. Uhhuh. Uh, and so like, I think pruning is also gonna be like, really, it's already becoming a thing, right? But like, letting self prune the con windowsswyx: be a big deal. Yeah. So, so don't leave the mistake. Don't leave the mistake in there.Cut out the mistake but tell it that you made a mistake in the past and so it doesn't repeat it.Jeff Huber: Yeah. But like cut it out so it doesn't get like distracted by it again. ‘cause really, you know, what is so, so it will repeat its mistake just because it's been, it's inswyx: theJeff Huber: context. It'sAaron Levie: in the context so much.That's a few shot example. Even if it, yeah.Jeff Huber: It's like oh thisAaron Levie: is a great thing to go try even ifJeff Huber: it didn't work.Aaron Levie: Yeah,Jeff Huber: exactly.Aaron Levie: SoJeff Huber: there's like a bunch of stuff there. JustAaron Levie: Groundhogs Day inside these models. Yeah. I'm gonna go keep doing the same wrongJeff Huber: thing. Covering sense. I feel like, you know, some creator analogy you're trying like fit a manifold in latent space, which kind is doing break program synthesis, which is kinda one we think about we're doing right.Like, you know, certain [00:31:00] facts might be like sort of overly pitting it. There are certain, you know, sec sectors of latent space and so like plug clean space. Yeah. And, uh, andswyx: so we have a bell, our editor as a bell every time you say that. SoJeff Huber: you have, you have to like remove those, likeswyx: you shoulda a gong like TPN or something.IfJeff Huber: we gong, you either remove those links to like kinda give it the freedom, kind of do what you need to do. So, but yeah. We'll, we'll release more soon. That'sAaron Levie: awesome.Jeff Huber: That'll, that'll be cool.swyx: We're a cerebral podcast that people listen to us and, and sort of think really deep. So yeah, we try to keep it subtle.Okay. We try to keep it.Aaron Levie: Okay, fine.Inside Agent Evalsswyx: Um, you, you guys do, you guys do have EVs, you talked about your, your office thing, but, uh, you've been also promoting APEX agents and complex work. Uh, yeah, whatever you, wherever you wanna take this just Yeah. How youAaron Levie: Apex is, is obviously me, core's, uh, uh, kind of, um, agent eval.We, we supported that by sort of. Opening up some data for them around how we kind of see these, um, data workspaces in, in the, you know, kind of regular economy. So how do lawyers have a workspace? How do investment bankers have a workspace? What kind of data goes into those? And so we, [00:32:00] we partner with them on their, their apex eval.Our own, um, eval is, it's actually relatively straightforward. We have a, a set of, of documents in a, in a range of industries. We give the agent previously did this as a one shot test of just purely the model. And then we just realized we, we need to, based on where everything's going, it's just gotta be more agentic.So now it's a bit more of a test of both our harness and the model. And we have a rubric of a set of things that has to get right and we score it. Um, and you're just seeing, you know, these incredible jumps in almost every single model in its own family of, you know, opus four, um, you know, sonnet four six versus sonnet four five.swyx: Yeah. We have this up on screen.Aaron Levie: Okay, cool. So some, you're seeing it somewhere like. I, I forget the to, it was like 15 point jump, I think on the main, on the overall,swyx: yes.Aaron Levie: And it's just like, you know, these incredible leaps that, that are starting to happen. Um,swyx: and OP doesn't know any, like any, it's completely held out from op.Aaron Levie: This is not in any, there's no public data which has, you know, Ben benefits and this is just a private eval that we [00:33:00] do, and then we just happen to show it to, to the world. Hmm. So you can't, you can't train against it. And I think it's just as representative of. It's obviously reasoning capabilities, what it's doing at, at, you know, kind of test time, compute capabilities, thinking levels, all like the context rot issues.So many interesting, you know, kind of, uh, uh, capabilities that are, that are now improvingswyx: one sector that you have. That's interesting.Industries and Datasetsswyx: Uh, people are roughly familiar with healthcare and legal, but you have public sector in there.Aaron Levie: Yeah.swyx: Uh, what's that? Like, what, what, what is that?Aaron Levie: Yeah, and, and we actually test against, I dunno, maybe 10 industries.We, we end up usually just cutting a few that we think have interesting gains. All extras, won a lot of like government type documents. Um,swyx: what is that? What is it? Government type documents?Aaron Levie: Government filings. Like a taxswyx: return, likeAaron Levie: a probably not tax returns. It would be more of what would go the government be using, uh, as data.So, okay. Um, so think about research that, that type of, of, of data sets. And then we have financial services for things like data rooms and what would be in an investment prospectus. Uhhuh,swyx: that one you can dog food.Aaron Levie: Yeah, exactly. Exactly. Yes. Yes. [00:34:00] So, uh, so we, we run the models, um, in now, you know, more of an agent mode, but, but still with, with kinda limited capacity and just try and see like on a, like, for like basis, what are the improvements?And, and again, we just continue to be blown away by. How, how good these models are getting.swyx: Yeah, I mean, I think every serious AI company needs something like that where like, well, this is the work we do. Here's our company eval. Yeah. And if you don't have it, well, you're not a serious AI company.Aaron Levie: There's two dimensions, right?So there's, there's like, how are the models improving? And so which models should you either recommend a customer use, which one should you adopt? But then every single day, we're making changes to our agents. And you need to knowswyx: if you regressed,Aaron Levie: if you know. Yeah. You know, I've been fully convinced that the whole agent observability and eval space is gonna be a massive space.Um, super excited for what Braintrust is doing, excited for, you know, Lang Smith, all the things. And I think what you're going to, I mean, this is like every enter like literally every enterprise right now. It's like the AI companies are the customers of these tools. Every enterprise will have this. Yeah, you'll just [00:35:00] have to have an eval.Of all of your work and like, we'll, you'll have an eval of your RFP generation, you'll have an eval of your sales material creation. You'll have an eval of your, uh, invoice processing. And, and as you, you know, buy or use new agentic systems, you are gonna need to know like, what's the quality of your, of your pipeline.swyx: Yeah.Aaron Levie: Um, so huge, huge market with agent evals.swyx: Yeah.Building the Agent Teamswyx: And, and you know, I'm gonna shout out your, your team a bit, uh, your CTO, Ben, uh, did a great talk with us last year. Awesome. And he's gonna come back again. Oh, cool. For World's Fair.Aaron Levie: Yep.swyx: Just talk about your team, like brag a little bit. I think I, I think people take these eval numbers in pretty charts for granted, but No, there, I mean, there's, there's lots of really smart people at work during all this.Aaron Levie: Biggest shout out, uh, is we have a, we have a couple folks at Dya, uh, Sidarth, uh, that, that kind of run this. They're like a, you know, kind of tag tag team duo on our evals, Ben, our CTO, heavily involved Yasha, head of ai, uh, you know, a bunch of folks. And, um, evals is one part of the story. And then just like the full, you know, kind of AI.An agent team [00:36:00] is, uh, is a, is a pretty, you know, is core to this whole effort. So there's probably, I don't know, like maybe a few dozen people that are like the epicenter. And then you just have like layers and layers of, of kind of concentric circles of okay, then there's a search team that supports them and an infrastructure team that supports them.And it's starting to ripple through the entire company. But there's that kind of core agent team, um, that's a pretty, pretty close, uh, close knit group.swyx: The search team is separate from the infra team.Aaron Levie: I mean, we have like every, every layer of the stack we have to kind of do, except for just pure public cloud.Um, but um, you know, we, we store, I don't even know what our public numbers are in, you know, but like, you can just think about it as like a lot of data is, is stored in box. And so we have, and you have every layer of the, of the stack of, you know, how do you manage the data, the file system, the metadata system, the search system, just all of those components.And then they all are having to understand that now you've got this new customer. Which is the agent, and they've been building for two types of customers in the past. They've been building for users and they've been building for like applications. [00:37:00] And now you've got this new agent user, and it comes in with a difference of it, of property sometimes, like, hey, maybe sometimes we should do embeddings, an embedding based, you know, kind of search versus, you know, your, your typical semantic search.Like, it's just like you have to build the, the capabilities to support all of this. And we're testing stuff, throwing things away, something doesn't work and, and not relevant. It's like just, you know, total chaos. But all of those teams are supporting the agent team that is kind of coming up with its requirements of what, what do we need?swyx: Yeah. No, uh, we just came from, uh, fireside chat where you did, and you, you talked about how you're doing this. It's, it's kind of like an internal startup. Yeah. Within the broader company. The broader company's like 3000 people. Yeah. But you know, there's, there's a, this is a core team of like, well, here's the innovation center.Aaron Levie: Yeah.swyx: And like that every company kind of is run this way.Aaron Levie: Yeah. I wanna be sensitive. I don't call it the innovation center. Yeah. Only because I think everybody has to do innovation. Um, there, there's a part of the, the, the company that is, is sort of do or die for the agent wave.swyx: Yeah.Aaron Levie: And it only happens to be more of my focus simply because it's existential that [00:38:00] we get it right.swyx: Yeah.Aaron Levie: All of the supporting systems are necessary. All of the surrounding adjacent capabilities are necessary. Like the only reason we get to be a platform where you'd run an agent is because we have a security feature or a compliance feature, or a governance feature that, that some team is working on.But that's not gonna be the make or break of, of whether we get agents right. Like that already exists and we need to keep innovating there. I don't know what the right, exact precise number is, but it's not a thousand people and it's not 10 people. There's a number of people that are like the, the kind of like, you know, startup within the company that are the make or break on everything related to AI agents, you know, leveraging our platform and letting you work with your data.And that's where I spend a lot of my time, and Ben and Yosh and Diego and Teri, you know, these are just, you know, people that, that, you know, kind of across the team. Are working.swyx: Yeah. Amazing.Read Write Agent WorkflowsJeff Huber: How do you, how do you think about, I mean, you talked a lot about like kinda read workflows over your box data. Yep.Right. You know, gen search questions, queries, et cetera. But like, what about like, write or like authoring workflows?Aaron Levie: Yes. I've [00:39:00] already probably revealed too much actually now that I think about it. So, um, I've talked about whatever,Jeff Huber: whatever you can.Aaron Levie: Okay. It's just us. It's just us. Yeah. Okay. Of course, of course.So I, I guess I would just, uh, I'll make it a little bit conceptual, uh, because again, I've already, I've already said things that are not even ga but, but we've, we've kinda like danced around it publicly, so I, yeah, yeah. Okay. Just like, hopefully nobody watches this, um, episode. No.swyx: It's tidbits for the Heidi engaged to go figure out like what exactly, um, you know, is, is your sort of line of thinking.Sure. They can connect the dots.Aaron Levie: Yeah. So, so I would say that, that, uh, we, you know, as a, as a place where you have your enterprise content, there's a use case where I want to, you know, have an agent read that data and answer questions for me. And then there's a use case where I want the agent to create something.And use the file system to create something or store off data that it's working on, or be able to have, you know, various files that it's writing to about the work it's doing. So we do see it as a total read write. The harder problem has so far been the read only because, because again, you have that kind of like 10 [00:40:00] million to one ratio problem, whereas rights are a lot of, that's just gonna come from the model and, and we just like, we'll just put it in the file system and kinda use it.So it's a little bit of a technically easier problem, but the only part that's like, not necessarily technically hard, it is just like it's not yet perfected in the state of the ecosystem is, you know, building a beautiful PowerPoint presentation. It's still a hard problem for these models. Like, like we still, you know, like, like these formats are just, we're not built for.They'reswyx: working on it.Aaron Levie: They're, they're working on it. Everybody's working on it.swyx: Every launch is like, well, we do PowerPoint now.Aaron Levie: We're getting, yeah, getting a lot, getting a lot of better each time. But then you'll do this thing where you'll ask the update one slide and all of a sudden, like the fonts will be just like a little bit different, you know, on two of the slides, or it moved, you know, some shape over to the left a little bit.And again, these are the kind of things that, like in code, obviously you could really care about if you really care about, you know, how beautiful is the code, but at the end, user doesn't notice all those problems and file creation, the end user instantly sees it. You're [00:41:00] like, ah, like paragraph three, like, you literally just changed the font on me.Like it's a totally different font and like midway through the document. Mm-hmm. Those are the kind of things that you run into a lot of in the, in the content creation side. So, mm-hmm. We are gonna have native agents. That do all of those things, they'll be powered by the leading kind of models and labs.But the thing that I think is, is probably gonna be a much bigger idea over time is any agent on any system, again, using Box as a file system for its work, and in that kind of scenario, we don't necessarily care what it's putting in the file system. It could put its memory files, it could put its, you know, specification, you know, documents.It could put, you know, whatever its markdown files are, or it could, you know, generate PDFs. It's just like, it's a workspace that is, is sort of sandboxed off for its work. People can collaborate into it, it can share with other people. And, and so we, we were thinking a lot about what's the right, you know, kind of way to, to deliver that at scale.Docs Graphs and Founder Modeswyx: I wanted to come into sort of the sort of AI transformation or AI sort of, uh, operations things. [00:42:00] Um, one of the tweets that you, that you wanted to talk about, this is just me going through your tweets, by the way. Oh, okay. I mean, like, this is, you readAaron Levie: one by one,swyx: you're the, you're the easiest guest to prep for because you, you already have like, this is the, this is what I'm interested in.I'm like, okay, well, areAaron Levie: we gonna get to like, like February, January or something? Where are we in the, in the timelines? How far back are we going?swyx: Can you, can you describe boxes? A set of skills? Right? Like that, that's like, that's like one of the extremes of like, well if you, you just turn everything into a markdown file.Yeah. Then your agent can run your company. Uh, like you just have to write, find the right sequence of words toAaron Levie: Yes.swyx: To do it.Aaron Levie: Sorry, isthatswyx: the question? So I think the question is like, what if we documented everything? Yes. The way that you exactly said like,Aaron Levie: yes.swyx: Um, let's get all the Fortune five hundreds, uh, prepared for agents.Yes. And like, you know, everything's in golden and, and nicely filed away and everything. Yes. What's missing? Like, what's left, right? LikeAaron Levie: Yeah.swyx: You've, you've run your company for a decade. LikeAaron Levie: Yeah. I think the challenge is that, that that information changes a week later. And because something happened in the market for that [00:43:00] customer, or us as a company that now has to go get updated, and so these systems are living and breathing and they have to experience reality and updates to reality, which right now is probably gonna be humans, you know, kinda giving those, giving them the updates.And, you know, there is this piece about context graphs as as, uh, that kinda went very viral. Yeah. And I, I, I was like a, i, I, I thought it was super provocative. I agreed with many parts of it. I disagree with a few parts around. You know, it's not gonna be as easy as as just if we just had the agent traces, then we can finally do that work because there's just like, there's so much more other stuff that that's happening that, that we haven't been able to capture and digitize.And I think they actually represented that in the piece to be clear. But like there's just a lot of work, you know, that that has to, you just can't have only skills files, you know, for your company because it's just gonna be like, there's gonna be a lot of other stuff that happens. Yeah. Change over time.Yeah. Most companies are practically apprenticeships.swyx: Most companies are practically apprenticeships. LikeJeff Huber: every new employee who joins the team, [00:44:00] like you span one to three months. Like ramping them up.Aaron Levie: Yes. AllJeff Huber: that tat knowledgeAaron Levie: isJeff Huber: not written down.Aaron Levie: Yes.Jeff Huber: But like, it would have to be if you wanted to like give it to an Asian.Right. And so like that seems to me like to beAaron Levie: one is I think you're gonna see again a premium on companies that can document this. Mm-hmm. Much. There'll be a huge premium on that because, because you know, can you shorten that three month ramp cycle to a two week ramp cycle? That's an instant productivity gain.Can you re dramatically reduce rework in the organization because you've documented where all the stuff is and where the answers are. Can you make your average employee as good as your 90th percentile employee because you've captured the knowledge that's sort of in the heads of, of those top employees and make that available.So like you can see some very clear productivity benefits. Mm-hmm. If you had a company culture of making sure you know your information was captured, digitized, put in a format that was agent ready and then made available to agents to work with, and then you just, again, have this reality of like add a 10,000 person [00:45:00] company.Mapping that to the, you know, access structure of the company is just a hard problem. Is like, is like, yeah, well, you just, not every piece of information that's digitized can be shared to everybody. And so now you have to organize that in a way that actually works. There was a pretty good piece, um, this, this, uh, this piece called your company as a file is a file system.I, did you see that one?swyx: Nope.Aaron Levie: Uh, yes. You saw it. Yeah. And, and, uh, I actually be curious your thoughts on it. Um, like, like an interesting kind of like, we, we agree with it because, because that's how we see the world and, uh,swyx: okay. We, we have it up on screen. Oh,Aaron Levie: okay. Yeah. But, but it's all about basically like, you know, we've already, we, we, we already organized in this kind of like, you know, permission structure way.Uh, and, and these are the kind of, you know, natural ways that, that agents can now work with data. So it's kind of like this, this, you know, kind of interesting metaphor, but I do think companies will have to start to think about how they start to digitize more, more of that data. What was your take?Jeff Huber: Yeah, I mean, like the company's probably like an acid compliant file system.Aaron Levie: Uh,Jeff Huber: yeah. Which I'm guessing boxes, right? So, yeah. Yes.swyx: Yeah. [00:46:00]Jeff Huber: Which you have a great piece on, but,swyx: uh, yeah. Well, uh, I, I, my, my, my direction is a little bit like, I wanna rewind a little bit to the graph word you said that there, that's a magic trigger word for us. I always ask what's your take on knowledge graphs?Yeah. Uh, ‘cause every, especially at every data database person, I just wanna see what they think. There's been knowledge graphs, hype cycles, and you've seen it all. So.Aaron Levie: Hmm. I actually am not the expert in knowledge graphs, so, so that you might need toswyx: research, you don't need to be an expert. Yeah. I think it's just like, well, how, how seriously do people take it?Yeah. Like, is is, is there a lot of potential in the, in the HOVI?Aaron Levie: Uh, well, can I, can I, uh, understand first if it's, um, is this a loaded question in the sense of are you super pro, super con, super anti medium? Iswyx: see pro, I see pros and cons. Okay. Uh, but I, I think your opinion should be independent of mine.Aaron Levie: Yeah. No, no, totally. Yeah. I just want to see what I'm stepping into.swyx: No, I know. It's a, and it's a huge trigger word for a lot of people out Yeah. In our audience. And they're, they're trying to figure out why is that? Because whyAaron Levie: is this such aswyx: hot item for them? Because a lot of people get graph religion.And they're like, everything's a graph. Of course you have to represent it as a graph. Well, [00:47:00] how do you solve your knowledge? Um, changing over time? Well, it's a graph.Aaron Levie: Yeah.swyx: And, and I think there, there's that line of work and then there's, there's a lot of people who are like, well, you don't need it. And both are right.Aaron Levie: Yeah. And what do the people who say you don't need it, what are theyswyx: arguing for Mark down files. Oh, sure, sure. Simplicity.Aaron Levie: Yeah.swyx: Versus it's, it's structure versus less structure. Right. That's, that's all what it is. I do.Aaron Levie: I think the tricky thing is, um, is, is again, when this gets met with real humans, they're just going to their computer.They're just working with some people on Slack or teams. They're just sharing some data through a collaborative file system and Google Docs or Box or whatever. I certainly like the vision of most, most knowledge graph, you know, kind of futuristic kind of ways of thinking about it. Uh, it's just like, you know, it's 2026.We haven't seen it yet. Kind of play out as as, I mean, I remember. Do you remember the, um, in like, actually I don't, I don't even know how old you guys are, but I'll for, for to show my age. I remember 17 years ago, everybody thought enterprises would just run on [00:48:00] Wikis. Yeah. And, uh, confluence and, and not even, I mean, confluence actually took off for engineering for sure.Like unquestionably. But like, this was like everything would be in the w. And I think based on our, uh, our, uh, general style of, of, of what we were building, like we were just like, I don't know, people just like wanna workspace. They're gonna collaborate with other people.swyx: Exactly. Yeah. So you were, you were anti-knowledge graph.Aaron Levie: Not anti, not anti. Soswyx: not nonAaron Levie: I'm not, I'm not anti. ‘cause I think, I think your search system, I just think these are two systems that probably, but like, I'm, I'm not in any religious war. I don't want to be in anybody's YouTube comments on this. There's not a fight for me.swyx: We, we love YouTube comments. We're, we're, we're get into comments.Aaron Levie: Okay. Uh, but like, but I, I, it's mostly just a virtue of what we built. Yeah. And we just continued down that path. Yeah.swyx: Yeah.Aaron Levie: And, um, and that, that was what we pursued. But I'm not, this is not a, you know, kind of, this is not a, uh, it'sswyx: not existential for you. Great.Aaron Levie: We're happy to plug into somebody else's graph.We're happy to feed data into it. We're happy for [00:49:00] agents to, to talk to multiple systems. Not, not our fight.swyx: Yeah.Aaron Levie: But I need your answer. Yeah. Graphs or nerd Snipes is very effective nerd.swyx: See this is, this is one, one opinion and then I've,Jeff Huber: and I think that the actual graph structure is emergent in the mind of the agent.Ah, in the same way it is in the mind of the human. And that's a more powerful graph ‘cause it actually involved over time.swyx: So don't tell me how to graph. I'll, I'll figure it out myself. Exactly. Okay. All right. AndJeff Huber: what's yours?swyx: I like the, the Wiki approach. Uh, my, I'm actually

Sollen neue Gentech-Verfahren an Tieren erlaubt werden, wenn sie dem Tierwohl dienen? Dann: US-Präsident Donald Trump lässt alle Hemmungen fallen. Mit welchen Konsequenzen? Und: Warum Singles wieder auf analogem Weg nach der grossen Liebe suchen. Revolverheld – Donald Trumps neue Weltordnung Nach dem Angriff auf Venezuela legt Donald Trump nach – und droht anderen Ländern wie Grönland und Iran mit Waffengewalt. Der US-Präsident bricht laufend Tabus und ignoriert damit ein Wahlversprechen an seine Basis. Das «Rundschau»-Porträt. Gentech-Ferkel – der Streit um hodenlose Schweine Um den Ebergeruch beim Kochen des Fleischs zu verhindern, werden jedes Jahr über eine Million Ferkel kastriert. Mit Gentechnik-Ferkel ohne Hoden wäre das zu vermeiden. Doch das führt unter Bauern zu heftigen Diskussionen. Moderator Gion-Duri Vincenz spricht zudem mit der Forscherin Christine Tait-Burkard, Tochter eines Schweizer Schweinehalters. Offline-Dating – Liebe auf den echten Blick Bei Dating-Apps wie Tinder herrscht Mitgliederschwund. Dafür boomen im Kampf gegen die Einsamkeit Offline-Veranstaltungen: Speed-Dating, Gipfelwandern und Fondue-Plausch. Die «Rundschau» hat einen 34-Jährigen und eine 66-Jährige auf der Offline-Suche begleitet.

Das Gentech-Moratorium in der Schweiz ist vom Parlament im Juni verlängert worden bis 2030. Das Parlament hat es vorher jedoch aufgeweicht. Für bestimmte Gen-Technologien, die neue Züchtungen ermöglichen, soll das Verbot nicht gelten. Im Bio-Sektor gehen die Meinungen darüber auseinander. Weitere Themen: Sie bezahlen keine Steuern, ignorieren staatliche Vorschriften oder bedrohen gar Behördenmitglieder: sogenannte Staatsverweigerer. Neu wird die Szene, in Zusammenarbeit mit der Zürcher Kantonspolizei, vom Nachrichtendienst des Bundes überwacht. Was war ausschlaggebend dafür? Vor 65 Tagen wurde Friedrich Merz als deutscher Bundeskanzler vereidigt. In der so genannten Generaldebatte im Bundestag musste er nun erstmals vor der Opposition seine Arbeit verteidigen. Der verbale Schlagabtausch zeigte gut, wo die Regierung aus CDU, CSU und SPD derzeit steht.

Gentechnisch veränderte Pflanzen dürfen in der Schweiz aktuell nicht angebaut werden. Die einzige Ausnahme bilden Forschungsprojekte im Bereich Gentechnik. Dieses Gentech-Moratorium hat das Stimmvolk heute vor 19 Jahren an der Urne angenommen - und es gilt noch bis Ende des nächsten Jahres.

Gentechnisch veränderte Pflanzen dürfen in der Schweiz aktuell nicht angebaut werden. Die einzige Ausnahme bilden Forschungsprojekte im Bereich Gentechnik. Dieses Gentech-Moratorium hat das Stimmvolk heute vor 19 Jahren an der Urne angenommen - und es gilt noch bis Ende des nächsten Jahres.

To raise awareness about genetic makeup and the critical importance of blood donations, the Blood Bank Department of the Ezra Long Laboratory has partnered with GenTech Analytica's Summer Genetics Program for students. This collaboration is a major step in the Blood Bank Department's mission to educate and encourage citizens about the value of blood donations, providing students with a thorough understanding of their genetic profiles and blood group significance.

Beer, Blues & BS: Flooded Basements, Storm Chasing Games & a Patriotic Disaster! Crack open a cold one and join Mark Kidder, Howard Blues, and LCL Geek for another round of laughs, brews, and BS! This week's episode is packed with hilarious stories, including Howard's basement flooding woes (turns out LCL Geek might know someone with even worse luck!), and the origin of Howard's legendary nickname "Living Embodiment of Charlie Brown." In this episode: What's on Tap? Howard dives into saisons from Boulevard Brewing, while LCL brings the hops with brews from Phat Fish Brewery. Don't Do That: Mark commits a series of epic fails you won't want to miss. Bad Luck Blues: LCL Geek and Howard drown their sorrows (in beer, of course) with some epic flood stories, and a hilarious look at Howard's "Charlie Brown" moment. Digital Brews: Mark gives his first impressions of the brand-new storm-chasing video game OUTBRK. Check out some gameplay footage and hear his first impressions! Tavern Talk: The guys chat about tornadoes, the Stanley Cup Finals, and the NHL Draft, and Howard throws down a fiery Hot Take about self-checkouts. Plus: Jury Duty stories, Howard's zombie film, 4th of July shenanigans, and a show-stopping patriotic disaster you won't believe! Don't miss this episode for a belly full of laughs and a glass full of cheer! Subscribe for more Beer, Blues & BS! GenTech - https://www.youtube.com/watch?v=5TKaUkyVZ3I Recorded 6.28.24 0:00 – Intro  3:47 – Kidder Streaming 5:01 – What's on Tap? 14:05 – Checking In With LCL Geek 18:23 – Jury Duty 21:08 – Don't Do That – Everything Kidder 22:16 –  Howard's Zombie Movie & Indie Film 29:15 – Bad Luck Blues – Flooding, Origin of Howard's Title 35:59 – The Tavern Door Gets Kicked Down 38:00 – Digital Brews: OUTBRK 42:11 – What's on Tap? Round 2 47:56 – Tavern Talk: Tornados in Iowa, Stanley Cup Finals 55:51 – Howard's Hot Takes: Self-Checkout 1:04:14 – Leave and Glue 1:06:57 – 4th of July 1:19:54 – Fireworks Simulator 1:27:32 – Cheap Plugs 1:31:29 – Final Thoughts 1:38:30 – Outro https://streamlabs.com/beerbluesbs https://beerbluesbs.podbean.com/ https://www.youtube.com/channel/UCHZIodCkbtyGAnkz_ICiMwQ https://open.spotify.com/show/1pnho1ZzuGgThbLpXbAs3t https://open.spotify.com/playlist/2Unmhz98iRYU97l18uJp99 https://www.twitch.tv/tuez13 2.50 #BeerBluesandBS #TripleBBSPodcast #Podcast #ComedyPodcast #BeerPodcast #HomeownerStruggles #BeerBluesBS #Podcast #Brews #Laughs #StormChasing #BadLuckBlues #4thOfJuly #BeerBluesBS #BrewsAndLaughs #WhatsOnTap #BadLuckBlues #DigitalBrews #OUTBRK #TavernTalk #HotTakeHoward #SelfCheckoutFail #DontDoThat #JuryDutyFails #ZombieFilmmaker #FourthOfJuly #PatrioticDisaster

In this engaging discussion, Dr. Rick Chromey, internationalspeaker, author, and cultural historian, shares fascinating insights on thetransformational role of technology in shaping generations. Dr. Chromeypresents his perspective on how the shifts brought on by developments such asholographic technology, AI, and robotics are reshaping our society. As heexplores future generations, he emphatically presents the 'iTech' and 'Robo' generations,asserting how today's children are navigating a fast-paced cyberculture. Thisconversation takes a deep dive not only into how our interactions withtechnology have changed, but also how it impacts the way we communicate, work,and perceive our surroundings. Join us as we unpack the past, observe thepresent, and anticipate the future of technology change in America.     00:00 Introduction and Naming the Current Generation  01:27 The Importance of Education and Self-Reflection  02:21 Guest Introduction: Dr. Rick Chromey  02:46 Rick Chromey's Background and Personal Life  03:39 Understanding Generational Naming and Shifts  04:29 The Inspiration Behind Rick's Book  06:12 The Impact of Technological Shifts on Generations  09:05 The Influence of Technology on Communication andLearning  09:49 The Future of Technology and Its Impact on Generations  09:53 The Role of Technology in Shaping Generational Psyche  10:14 The Impact of Technological Shifts on Society  11:10 Understanding the Past to Navigate the Future  18:38 The Evolution of Social Media Platforms  22:00 The Future of Technology: Holographic, AI, andRobotics  29:14 The Creepiness of New Technologies  30:09 The Normalization of Technology in Our Lives  30:25 The Future of Robots and AI in Our Society  30:53 The Impact of Technology on Jobs and the Economy  31:55 The Amish and Technology: A Case Study  32:22 Living Off the Grid: An Alternative Lifestyle  32:44 The Ethical Implications of Advanced Technologies  33:55 The Future of Warfare: Robots and AI  34:26 The Role of Robots in the Workplace  35:13 The Impact of COVID-19 on Our Relationship withTechnology  36:24 The Shift to Remote Work and Online Business  40:21 The Changing Landscape of Transportation  43:31 The Future of Autonomous Vehicles  45:12 The Industrial Revolution and Its Impact on Society  46:10 Final Thoughts and Call to Action     http://www.rickchromey.com/  https://www.facebook.com/rickchromeyspeaker  https://www.twitter.com/Dr_Rick_Chromey  https://www.youtube.com/channel/UCoXjDFeB-2ZcQmsOeISJq-A     Get your free copy of GenTech!  at https://dl.bookfunnel.com/37oz433xx9  

AstroFegs Tracklist: 1. Steve Meyer - Far Away 2. Marc Ward - Dayton 3. Impulse Wave & Ren Faye - Only Have A Minute 4. D-Myo & Dj-Elven - The Last Starfield 5. Will Atkinson - Cosmic Heartbreak 6. 0Gravity - Behind The Lights 7. Emma Hewitt x Xijaro & Pitch - Everlasting 8. Angelus With Liam Melly & JSKA - Unbroken 9. M83 Feat. Susanne Sundfør - Oblivion(AstroFegs Bootleg - Bizarre Hazar Vocal Edit) 10. Nu Spirit - Eagles Call 11. DJ T.H. & Rebecca Louise Burch & Fawzy - Forever(Christopher Corrigan Rmx) 12. Gary McPhail - What Happened 13. Dennis Chenson - Angel of Light Bizarre Hazar Tracklist: 01. Sean Tyas pres. AbSTrakt - In The Dark 02. Sean Tyas & Darren Porter vs. Evanescence & Haliene - The Potion Brings Me To Life (Bizarre Hazar Immortal Reincarnation) 03. Simon Patterson & WAIO vs. Richard Durand vs. Lostly ft. Nadia Ali - Raptured Coffin Smackdown (Bizarre Hazar Mach Mayhem) 04. AstroFegs vs. Rank 1 vs. Bryan Kearney & Bo Bruce - Shine A 1337 Breathing Light (Bizarre Hazar Melded Montage) 05. Kaimo K vs. Elara vs. Motorcycle - As The Rush Starts Again (Kaimo K Mashup) 06. Tiesto vs. Eddie Bitar - Lethal Rollercoaster (Ben Nicky Headfuck) 07. Kaimo K vs. Jo Cartwright vs. Andain - Love Beyond Beautiful Things (Kaimo K Mashup) 08. Sean Tyas vs. Metta & Glyde vs. Ronski Speed ft. Christina Novelli - It'll End In Twin Chrome Turbos (Bizarre Hazar 'To The Wheels' Crash-up) 09. Simon Patterson vs. Stoneface & Terminal vs. Yves De Reuter vs. John O'Callaghan - Taxi Blueprint Out of Nowhere (JOC Noodle) 10. Simon Patterson vs. Three Days Grace - Never Too Late To Miss You (Nostalgic Dreamers Mashup) 11. Metta & Glyde ft. Saorise Ronan - The Lovely Cynosure (Bizarre Hazar Guiding Glow) 12. Armin van Buuren vs. Arctic Moon vs. OneRepublic - If I Lose Myself Coming Home (Shura Vlasov Mashup) 13. Marlo vs. Avao vs. Andy Moor, Ashley Wallbridge & Indecent Noise - We Are Faces Activate Future (Eamyzuhaimi Mashup) 14. Above & Beyond ft. Richard Bedford vs. OverDrive vs. Exis & Dimatik - Orchestral Sun & Moon (Faiez Barker Mashup) 15. Sam Laxton vs. Alexander Popov vs. Robert Miles, Zac Waters & Amir vs. Zedd ft. Foxes - Meaning of Multiverse Children Clarity (Eamyzuhaimi Mashup) 16. Impulse Wave vs. Techy vs. TJR & Vinai vs. David Rust vs. Sebastian Ingrosso & Tommy Trash ft. John Martin - Bounce Gods Reload Endgame (FIR Mashup) 17. Urban Astronauts vs. Jorn van Deynhoven & Temple One - See The Halo (Aurosonic & Quino Mashup) 18. Sean Tyas vs. Simon Patterson - Mood Banshee (Nessai Mashup) 19. RAM & Jorn Van Deynhoven vs. Dash Berlin with Cerf, Mitiska & Jaren - Man on the RAMsterdam (Dash Berlin Mashup) 20. International Chaos vs. Warp Brothers & Adrenaline Dept. vs. Gentech vs. Scooter vs. G-Spott & Lucas Deyong vs. Marcel Woods & Renegade System vs. Human Resource vs. Ferry Corsten - Diss! No Advanced Bass Citizen Dominator (Mr. Trancetive Mashup) 21. Simon Patterson vs. Greg Downey vs. Kevin Rudolf - Let It Grudge Thump (Unknown Mashup) 22. Above & Beyond vs. John O'Callaghan - Big Sky Home (Daniel Kandi Reproducted Bootleg) 23. Simon Patterson vs. Ben Nicky ft. Cassandra Fox - One Latika (Ben Nicky Vocal Mashup) 24. The Killers vs. Exis - Brightside Survival (STANDERWICK Mashup) 25. Metta & Glyde ft. Robin Williams - 11:11 Make A Wish (Bizarre Hazar Gentle Jack-up)

In this episode, we have not one, but two special guests - Christian Jamal and Amel Kilic, co-founders and CEO's of GenTech Marketing. Listen as they join us to discuss the importance of lead generation and paid ads for your business. Tune in to hear their valuable insights and expertise on digital marketing strategies that can help take your business to the next level. Don't miss out on this informative conversation! If you are looking for a publicist, Otter PR can help you. Visit our website https://otterpr.com/ 

Australian DJ & producer Rick Guyez provides the guest mix for Episode 196! | The Hyper Reality Radio show airs on the 1st and 3rd Thursday of each month on DI.FM/harddance | Hour 1 - XLS 01. Dominik Schwarz - Silent (Original Mix) 02. Jody 6 & Marie Vaunt - Acid in Your Mind (Original Mix) 03. A*S*Y*S - Faceplant feat. Jowan (A*S*Y*S Rework) 04. Sonic Wave - Bipolar Mental (Extended Mix) 05. Ryan K - Caesium (Extended Mix) 06. Jackob Rocksonn - The Presence (Original Mix) 07. Marco V - GODD (Mark Sherry EXT Remix) 08. Alex Di Stefano - Injection (Extended Mix) 09. Last Soldier - Alliance (Extended Mix) 10. Code 2 - Ur Gonna Want Me (Extended Mix) [Track of the Week] 11. DJ Darroo - Another Dimension (XLS Remix) 12. Renegade System - Feelin' In Demand (Extended Mix) 13. Amazingblaze - On The Grind (Original Mix) 14. Dr Willis - Shark Infested Waters (Kamui Remix) Hour 2 - Rick Guyez 01. Tempo Giusto - Social Animal [Intro Edit] 02. Olive - You're not alone (Argy UK Rework) 03. Scot Project - G2 (Good Times) 04. Creeds - Push Up 05. DERB - The Revolution 2022 (DJ Thera Mix) 06. Creeds - Work That 07. Storm - Time to burn (Jam El Mar Remix) 08. Ian M - Defiance 09. Rick Guyez - More and More 10. Armin Van Buuren - Control Freak (Rick Guyez Rework) 11. Gentech meets DJ Sequenza - Tricky Tricky 12. REM-X - Wondering Mind 13. DJ Pawel C - Canadian Beef 14. Pete Kingwell vs Loki - Ripped Tooth (Tricky DJ remix) 15. Mindflux - Intimate People 16. J Rogers - Genocide (Rick Guyez Remix) 17. TNT x Rudeejay - The Music is moving 18. Madora - The moment

Hello Everyone, Welcome to The Vanishing Point, Recorded live in Boston at Big Night Live. - Full Tracklist Here: 1. Faithless, Maceo Plex - Insomnia 2021 (Epic Mix) 2. Sollos - Introspection (Extended Mix) 3. Sven Väth, Bart Skils, Weska - Metal Master – Spectrum (Bart Skils & Weska Reinterpretation) 4. Danny Fontana - Multiverse 5. Frank Spector - OMEN (Extended Mix) 6. Julian Jeweil - Boreal (Original Mix) 7. Dangelo (Arg) - NGTS-1B (Original Mix) 8. Kamil Van Derson - We Are Nobody (Original Mix) 9. Joyhauser - Vesperi (Original Mix) 10. John P - Diode (Original Mix) 11. The Future Sound Of London - Papua New Guinea (Bart Skils Remix) 12. M.I.K.E. Push - Urban Shakedown (Bryan Kearney Remix) 13. David Forbes - Fragments of Time 14. Ramon Tapia - Song of Sirens (Original Mix) 15. NyTiGen - Dream (Extended Mix) 16. Cold Blue Audrey Gallagher - Broken Things (Extended Mix) 17. Impulse Wave - Shine Off Colors (Extended Mix) 18. Ed Sanchez - Missing You (Original Mix) 19. Planet Perfecto - Bullet In The Gun (Impulse Wave Rework) 20. Gentech & DJ Sequenza - Tricky Tricky (Extended Mix) 21. Paul Denton - Mr Toad (Original Mix) 22. Indecent Noise - The House of Fun (Original Mix) 23. Aly & Fila Charlie Walker Scott Bond - Shadow (Paul Denton Extended Remix) 24. Daniel Skyver - We Go Again (Extended Mix) 25. Amos & Riot Night - You'll Never Find Me 26. Inoblivion - The Ancient Curse (Extended Mix) 27. Danny Eaton - Away From You (Extended Mix) 28. NyTiGen & Trance Reserve - Driving (Extended Mix) 29. Craig Connelly Paul Denton - Quantum Eraser (Extended Mix) 30. Maria Healy & Deirdre McLaughlin - Believe In You (Extended Mix) 31. Niko Zografos - Time Passes By (Extended Mix) ––––– Cheers, Kaeno facebook.com/kaeno.music instagram.com/kaeno itunes.com/kaeno twitter.com/kaeno

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners of Tampa Bay! If you are someone looking to start your own business, you won't want to miss this podcast! AVAILABLE ON ALL PLATFORMS

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners of Tampa Bay! If you are someone looking to start your own business, you won't want to miss this podcast! AVAILABLE ON ALL PLATFORMS

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners of Tampa Bay! If you are someone looking to start your own business, you won't want to miss this podcast! AVAILABLE ON ALL PLATFORMS

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners of Tampa Bay! How do you translate vision into reality? Regina Rached, photographer and founder of Offbeat Boudoir, discusses taking appropriate action with the right mindset and moving in the right direction from where you are to where you want to be to achieve your goals. The key to success is to stay focused on your vision and also to be realistic about your current situation. If you are someone looking to start your own business, you won't want to miss this podcast! AVAILABLE ON ALL PLATFORMS

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners of Tampa Bay! Do you want to unlock your greatest potential? When you hit rock bottom, it can feel impossible to get out. Our guest today, Cesar Hernandez, shares invaluable lessons on how to get yourself out of those hard places and how rock bottom can actually unlock your best self and your greatest potential! When it comes to unlocking your fullest potential, you need to step back and examine who you are now and who you want to be in the future. If you are someone looking to start your own business, you won't want to miss this podcast! AVAILABLE ON ALL PLATFORMS

Themen dieser Sendung: (05:46) Darf Deutschland Schweizer Munition an die Ukraine liefern? (10:52) Lula gewinnt Brasilien-Wahl denkbar knapp (15:40) Regenwald-Abholzung: Lula soll's richten (19:38) Neues Kräfteverhältnis im Südkaukasus (24:52) Gentech gegen die Auswirkungen des Klimawandels? (29:56) Die neue höchste Richterin Europas (35:08) Frankreichs Südwesten nach den Bränden

Welcome to my new episode 'Dynamic Trance Universe' podcast. Доброго времени суток, дорогие друзья! В эфире 354-й эпизод подкаста-путеводителя в замечательный мир trance музыки. #HappyHalloween #TrickorTreat? #DTUPodcast354 #Trance #TechTrance #PsyTrance #Trancefamily TRACKLIST: 01. Azathoth & Charliecharlie - Halloween [STARLIGHT PRODUCTIONS] 02. Frank Spector - Omen [ARMIND] 03. Corti Organ & Heatbeat - Dr. Chaos [FIND YOUR HARMONY] 04. Kate Bush - Running Up That Hill (Press Play Remix) [FREE/EMI] 05. Corti Organ - The Joker (Maarten de Jong Remix) [INHARMONY] 06. Will Atkinson - Beans [VICTIMS HELPLINE] 07. Infected Mushroom & Bliss - Ani Mevushal [MONSTERCAT] 08. Freedom Fighters - Clockwork [VII] 09. Astrix & Freedom Fighters - Burning Stones (Simon Patterson Remix) [VII] 10. Heatbeat - Magical Princess Owl (Jordan Suckley Remix) [WHO'S AFRAID OF 138?!] 11. Braincell - Sound Frequencies (Alienatic Remix) [NANO RECORDS] 12. Hypnocoustics & Mandala (UK) - Howling Totem [NANO RECORDS] 13. Earthspace x Ital - Afterlife [NANO RECORDS] 14. Sneijder - Polarize (Second Sine Remix) [AFTERDARK] 15. Sam Jones - Incoming [OUTBURST] 16. John Askew - Bat Shit Crazy [FSOE] 17. Sentinel 7 - Overlord [PSYTRIBE] 18. Frenètic - Mystic Owl [MOSAICO] 19. Gentech meets DJ Sequenza - Tricky Tricky [OUTBURST] 20. Audorn - Pump This Party [OUTBURST TWILIGHT] 21. Icarus - Digital Pill [SPEEDSOUND] 22. Lil' Yim Yim - This Is Halloween (Techno Remix) [CD-R] Слушайте, скачивайте и пишите комментарии, буду рад их почитать. И помните, что музыка должна находиться вне политики. Мирного неба вам над головой. До скорой встречи. ▶ PromoDJ: promodj.com/aeroritmix ▶ Mixcloud: www.mixcloud.com/aeroritmix-dj ▶ Souncloud: soundcloud.com/aeroritmix-dj ▶ VK: vk.com/public204888851 Подписывайтесь на мой подкаст (Subscribe to My Podcast): ● Apple Podcasts - podcasts.apple.com/ru/podcast/… ● Google Podcasts - podcasts.google.com/feed/aHR0c… ● Pocket Casts - pca.st/drpc1gfj Слушайте и наслаждайтесь! Listen & Enjoy! From Russia with Love!

Hello everyone, and welcome to a new edition of TVP Reloaded, featuring my top-selected tunes for October 2022 (Halloween Edition). ––––– 1. Luminn - Imagination (Extended Mix) 2. Impulse Wave - Shine Off Colors (Extended Mix) 3. Kita-Kei - Corundum (Henry Moe & N-sKing Extended Remix) 4. Peetu S - Halloween (Extended Mix) 5. Nico Cranxx - Mesin (Extended Mix) 6. Corona vs. DJ Isaac - The Rhythm of the Party (Black XS Mashup) 7. Adam Reece - A Shade Darker (Extended Mix) 8. Gentech & DJ Sequenza - Tricky Tricky (Extended Mix) 9. Paul Denton - Mr Toad (Original Mix) 10. Mark Sherry & Dr Willis - Here Come the Drums (Peter Fern Extended Remix) 11. Indecent Noise - The House of Fun (Original Mix) 12. The WLT - Outlander (Extended Mix) 13. Paradise - See The Light (David Nimmo Extended Remix) 14. Niko Zografos - Time Passes By (Extended Mix) 15. RAM - Buenos Aires Angels (Extended Mix) 16. Yakooza - Cocaine (Kinetica Extended Remix) 17. Paul Denton - Recoil (Extended Mix) 18. Rene Ablaze & Claas Inc. - Corpus Callosum (Extended Mix) 19. Plastic Boy - Twixt (Yahel vs Eran Buhbut Meets MIKE Push Rework) 20. Key4050 - Rebel 21. Kai Tracid, Tom Wax, A*S*Y*S - Freedom of Expression (Dark Acid Mix) 22. Casey Rasch feat. Taranhawk - Lords of War (Paul Webster Remix) 23. Wippenberg - UR (John O'Callaghan Urrr Rework) 24. John O'Callaghan - Oh Yes 25. Dogzilla - Without You (Will Atkinson Extended Remix) 26. David Forbes - Lap Of The Gods (Original Mix) 27. David Forbes - 12K.MCG 28. Kaeno - Samuari (Renegade System Remix) 29. Indecent Noise - Glitches (Unreleased Personal Hard Mix) 30. Marco V - Echoes (Indecent Noise Bootleg Mix) 31. Argy - Bearpit (Scot Project Remix) 32. Marco V vs. Simon Patterson - Godd Smack (David Forbes Mashup) ––––– Cheers, Kaeno facebook.com/kaeno.music instagram.com/kaeno itunes.com/kaeno twitter.com/kaeno

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners of Tampa Bay!

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners of Tampa Bay!

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners of Tampa Bay!

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners!

The Outburst Radioshow is a weekly radio show hosted by electronic music producer and DJ, Mark Sherry. He brings you the very best upfront trance, tech-trance & techno releases from the scene's leaders, including exclusive plays from his own record labels, Outburst, Techburst & Outburst Twilight For more information on Ouburst Radio, please go to podlink.to/outburstradio or follow us on Twitter for live tracklisting The Outburst Radioshow - Episode #621 (23.09.22) *The Techburst Selection** 01. Jam & Spoon - Odyssey To Anyoona (Wehbba Remix) [Black Hole] 02. Dok Martin - Want Your Love (Original Mix) [1605] 03. Sander van Doorn - Bells Keep Ringin [Doorn] 04. Yves Deruyter - Ravers United [YDR] 05. The YellowHeads - Acid Rain [Reload Black] 06. UMEK - Persona [1605] 07. Mike EFEX - Monsters [Coldharbour Black] 08. KJAER - Acid Over Berlin [Fine Artistry] 09. Heerhorst - Deliver [1605] ................................................... 10. Audorn - Pump This Party [Outburst Twilight] 11. Simon Patterson - Voodoo [VII] 12. Agnelli & Nelson - Holding On To Nothing (Tasso Bootleg) 13. Peetu S - Reach For the Lasers [Outburst] 14. **Outburst Cut** Kate Bush - Running Up That Hill (Mark Sherry's 'Stranger Things' Remix) 15. Sharpside - Space Cruising (Wehbba Remake) [Rotation] 16. Will Atkinson - Freak Of The Week [Armind] 17. Gentech meets DJ Sequenza - Tricky Tricky [Outburst] 18. Gary Burrows - This Trip [Off] 19. Sebrof - Supershokk [Midimal] 20. I-K-O - F.K.K. [Sonaxx] 21. Luigi Madonna - CNTMP 3.01 [Contempo]

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners!

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners!

We all know that our gut health is important for our overall health, but did you know that our oral microbiome is just as important? In fact, research has shown that there is a strong link between our oral health and our overall health.   For example, studies have shown that people with gum disease are more likely to develop heart disease, stroke, and other chronic illnesses. Therefore, it's important to take care of your oral health in order to maintain your overall health.   David Lin is a leading expert on the oral microbiome and he's going to be joining us on the show today to talk about how we can maintain our oral health and why it's so important for our overall health.   About David Lin: David Lin PhD is Co-founder and Chief Scientific Officer at Bristle. David received his PhD in Microbiology and Immunology from the University of Michigan, Ann Arbor, his MS in Biology from California State University, Fullerton, and his BS in Biotechnology from University of California, Davis. He was a postdoctoral researcher at Genentech before becoming a Scientist at Twist Bioscience. He has over 10 years of molecular biology, microbiology, genomics, and synthetic biology, and infectious disease experience across academia, public health, and industry.   In this episode, you'll learn:   What the oral microbiome is and why it's so important for our health How to maintain a healthy oral microbiome The link between our oral health and overall health How poor oral health can lead to chronic illnesses And much more!   So tune in now to learn how you can maintain a healthy oral microbiome and improve your overall health!   (00:00): "Worrying is like a rocking chair. It gives you something to do, but it gets you nowhere." - David Lin.   (00:08): So the big question is how do women over 40, like us keep weight off, have great energy balance. Our hormones in our moods feel sexy and confident and master midlife. If you're like most of us, you are not getting the answers you need and remain confused and pretty hopeless to ever feel like yourself. Again. As an OB GYN, I had to discover for myself the truth about what creates a rock, solid metabolism, lasting weight loss, and supercharged energy. After 40 in order to lose a hundred pounds and fix my fatigue. Now I'm on a mission. This podcast is designed to share the natural tools you need for impactful results. And to give you clarity on the answers to your midlife metabolism challenges, join me for tangible natural strategies to crush the hormone imbalances you are facing and help you get unstuck from the sidelines of life. My name is Dr. Kyrin Dunston welcome to The Hormone Prescription Podcast.   (01:04): Hi, everybody. Welcome back to another episode of The Hormone Prescription with Dr. Kyrin. Thank you so much for joining me today. My guest today, David Lin PhD is a co-founder and chief scientific officer at Bristol. You might think of Bristol as bristles on your toothbrush. This is a different kind of bristle. Maybe you've heard about the connection between your oral microbiome and your overall systemic health like heart and brain and more. Maybe you haven't, but whether you have, or haven't, you need to know about this. And if you know a little bit about it, you need to know more. So David is gonna share that with you today so that you don't just sit there worrying like a rocking chair about your health and what can you do, but you really get some actionable information, some steps that you can take to improve your health and taking care of your oral microbiome is one of those things that you're not gonna hear about at your dentist that you could be doing to move your health to the next level.   (02:09): So I'll tell you a little bit about David and then we'll get started. David received his PhD in microbiology and immunology from the university of Michigan and armor and his MS in biology from California state university Fullerton, and his bachelor's in biotechnology from university of California Davis. That's a lot of science. He is a science nerd. Let's just say . And he loves talking about the oral microbiome. He was a post-doctoral researcher at Gentech before becoming a scientist at twist bioscience and has over 10 years of molecular biology, microbiology, genomics, and synthetic biology and infectious disease experience across academia, public health and industry. This is just the guy you want informing you about how to understand the key of your oral microbiome for better, better health. Welcome David.   (03:08): Thank you. I'm very excited to be here.   (03:10): Yes. I think that most people are not aware of how this small little real estate on their face, their mouth affects the entire rest of their body to such a high degree. So I really wanted to have you on to highlight that for them and they can get some tools and start taking action to improve their oral health so they can improve their overall health. What introduced you to the big impact that oral health has on systemic health?   (03:44): That's a good question. Well, I'm a scientist by training and through many years of school, I've learned to a lot about microbiology, a lot about bacteria and basically the way that they do things and how they interact with your body. And recently, at least in the past decade or two, there's been a lot of research that has shown that the gut microbiome is really important for your overall health. It helps with digestion. It controls a lot of your mood and it does a lot of things, but what's been largely ignored is that there's actually another microbiome. That's the second largest and most diverse microbiome in your body. And it's your mouth. You swallow a hundred billion bacteria every day. You are what you eat and those bacteria are in your mouth. And they do so much for us that we really don't. We don't acknowledge. Did you know that oral bacteria, they actually control some of your blood pressure the way they do this is by reducing nitrate. So there's this circular connection in your mouth where they can reduce nitrate. And that increases the nitrate level, nitric oxide levels in your blood. That's just one of many ways that they help you do things.    (04:49): You know, that's interesting. I know some people, women are listening and saying, oh, maybe when I go for my blood pressure check at my doctor's office, I should ask them to check my oral microbiome. I think the average doctor would just look at you, like, what are you talking about? It would . They probably wouldn't know what you're talking about in terms of clinical utility. I know you're affiliated with a company that does testing of the oral microbiome. What percentage of doctors would you say are savvy about this interaction and actually know to order tests like this recommend tests like this work with tests like this?   (05:25): Very, very few. So I think one of the things about medicine is that it's relatively slow moving. There's a lot of tradition that's been built into not only systemic medicine, so, you know, your physician, but also dentistry. Dentistry is a really old practice and they haven't introduced almost any new technologies for like a hundred years. We still operate in the same way we've been doing for a long time. And that is we treat the symptoms as we see them, which is really unfortunate. There's very little preventive measures that we use to really tackle some of the biggest problems we have. I mean, cavities and gum disease, everybody still gets them. It's like, I think 70% of individual over 65 will have periodontal disease and it's entirely preventable. It's just a bacterial infection. That's a very long term bacterial infection. And if you catch it early enough, you don't have to get it.   (06:13): Same with cavities. Cavities are very specific bacteria. They colonize your teeth, they create acid. And unfortunately practitioners nowadays, they, most of them really don't use any of these kinds of tools to screen their patients. I think some of that may have to do with medicine itself, just the way that that we practice. And the other part of it is really that research moves very slowly. So academia to translate a research, finding into something that's really useful for people takes a very long time of development. And hopefully, you know, my company bristle, we're trying to address that at least for oral health.   (06:47): Yes, it's so true. It can take decades. I think that the average is something like three decades and sometimes it's way longer than that, for instance the use of fluoride and toothpaste and water, how does that affect the oral biome?   (07:05): Yeah. So there haven't actually been any very compelling trials regarding the use of at least every day fluoride, which is a very low concentration in your toothpaste, but generally it's not a very powerful antimicrobial. It really doesn't do that much in killing bacteria. But what it really does is to help you remineralize your teeth because fluoride actually helps to reserve calcium onto your tooth surface. So it helps protect your teeth that way. But I think what's more exciting is not just things like fluoride, but there have been newer compounds that have been out where people have shown kind of that they don't have systemic effects like fluoride does, but they can still help re minimalize teeth. So something like nano hydroxy, appetite, even things like arginine. So arginine is, is just an amino acid, but it helps prevent cavities. And, and the way it does it is by actually modulating the oral microbiome. It's a very interesting connection.   (08:05): And is that when swallowed orally Swed orally and how is it administered that it's shown to decrease cavities by altering the microbiome? Yeah,   (08:16): So arginine it just, if you chew it and if it sticks around on your teeth, I'm not actually sure if there have been any tests for ingestion, but if you chew it or if you apply it as a toothpaste, it acts as a prebiotic and it activates this pathway called the arginine D M a pathway, which increases the pH of the mouth and the, the way it modulates the oral microbiome is that there's some bacteria that can metabolize the Aine very well and turn it into ammonia, which increases the pH. And that actually prevents the acid generating bacteria from colonizing the tooth because acid generating bacteria actually really like acidic environments and ammonia is the opposite. So it, it prevents them from growing.   (08:56): Okay. And so what are some everyday habits that people might have that might hurt their oral microbiome and what are some habits they might have that might improve?   (09:07): The first one is using alcohol based mouthwash. That's really bad for you actually. So alcohol is an antiseptic that we use, you know, on our hands. We use it to disinfect things, but it turns out that the microbiome of the mouth, there are very important, good bacteria in there that are important for preventing the bad ones from growing and those good ones. We can kill them by using alcohol based mouthwash. So there was a study recently that had shown that routine use of over the counter mouthwash was actually associated with hypertension. And the reason for that was because these nitrate, reducing bacteria were actually completely going away and they didn't come back because these people were using mouthwash twice a day. And so you never give a chance for good bacteria to populate. And you ended up with dysbiosis of the mouth. That's   (09:54): Fascinating that the regular use of the alcohol containing mouthwash increased hypertension, fascinating. What are some other habits that we have that hurt our oral microbiome?   (10:05): Definitely our diet. This probably isn't unique to just the oral microbiome, but the amount of sugar and processed food that we eat is just off the charts now, compared to where we were even just 20 years ago, even 30 years ago. And so the rates of cavities have gone sky high. And so that's like the main thing that I tell most people it's well, can I fix right now without having to buy anything or actually like change my habits besides diets gotta be diets. Like the diet is the only thing that is entirely controllable and will fix of most of the problem. Stop eating sugar. just the simple sugars are a huge problem.   (10:44): just stop. Just say no,   (10:46): Just   (10:47): Say no. Okay. And how about flossing and brushing? Just gotta say it cuz some people still didn't get the memo.   (10:54): Oh my gosh. It's really surprising. Right. And I think we always recommend people brush twice a day floss once a day, we actually published a little bit of research of our own, of what flossing does to the microbiome. We actually saw that flossing frequency correlates with improvements in oral health and the oral microbiome. So when we measure the microbiome, what we're talking about is there's very specific bacteria in your mouth that we call them periodontal pathogens. And they're the ones that cause gum disease. And we measure these in your saliva at Bristol. And we measure them against the bacteria that prevent them from growing. And we found that people who floss once a day had very low levels of these bacteria, of the bad bacteria in their mouth compared to the good ones, but the people who didn't floss at all, it was an inverse correlation.   (11:40): They had very low levels of the good ones and a lot of the bad ones, why this happens. We think it's because most of these pathogens they're called a robes, which means that they can't grow in the presence of oxygen. They really like your gum line. And they like growing into the pockets of your teeth because there's no oxygen there. And so by flossing you can introduce oxygen. You can also mechanically remove some of the dental plaque that's down there that protects from the environment. And really you want those pockets to be exposed to saliva. You want them to be exposed to anything you don't want them to just be rooted in bacteria in pathogenic bacteria.   (12:15): Can we give some of them names? Cause I know it would be easier they could hear. So what are some of the good bacteria that we want to foster that we wanna make friends with?   (12:25): Yeah. So there's a few bacteria such as amorous pair of influenza. Your, the names are not that important, but most of them are aerobic. So they're strep. ATOC minus. I think if you go to a website, you'll, you'll find a list with a way to spell them out. But generally these are they're in your mouth. And the way that they protect you is actually really interesting. They make a set of compounds called bacteriocins well, not all of them, but some of them do. And this, these bacteria sins are really good at killing other bacteria, specifically killing anaerobic bacteria. It's really interesting. They cause oxidative stress in those bacteria. And that's a, a mechanism where oxygen can kind of is extremely detrimental to their growth. And some of these bacteria sins act as stress inducers.   (13:15): So the AOBs wanna hide little cavities and cause problems. Mm-Hmm as acidosis, which is then gonna start eroding teeth. What about mouth breathing and the health of your microbiome, right? There's been recent data about the number of people that are mouth breathers and how it can adversely affect your microbiome and mouth taping has become a thing. Can you talk a little bit about that?   (13:42): Absolutely. So mouth breathing is a really interesting phenomenon and it doesn't really directly affect the oral microbiome in that it's the mouth breathing itself, but the active mouth breathing actually reduces the amount of saliva in your mouth. And saliva's really important because it has antimicrobial peptides. It has antibodies in it, it has minerals and most importantly, it just helps to keep your mouth clean. So you're constantly shedding saliva from, I think it's like hundreds of salivary glands in your mouth and they really helped to just shed things. It helps to coat your teeth, coat your gums and make it so that the bacteria in your mouth are kept at low levels. Because once you get outgrowth, that's when problems really happen. And by mouth breathing, you're drying up the salivary glands. You're reducing the amount of saliva on your teeth and your gums and dry mouth is the main cause of oral microbiome dysbiosis, which   (14:38): Is cause is that for most people?   (14:39): Yeah. A lot of people have dry mouth and they're not actually aware dry mouth causes, gum disease, cavities, bad breath, extremely common, but people think they wake up in the middle of the night. They've been mouth breathing that it's totally normal. And they're like, eh, I'll just drink a glass of water. But you know, this constant act of mouth breathing and having a dry mouth every day leads to dysbiosis.   (15:00): And for everybody listening, before you go seal your mouth up with a piece of tape, read about how to do mouth taping please. Cuz I know, I remember when I first heard about it and I thought mouth taping, I thought it meant a piece of tape, a crushable mouth. So don't do it until you read about it and learn about it. So my people are mostly women 40 to 60 and over and they're wanting to know what they can do to improve their health. And how does they've learned about the microbiome and the gut? And now they're wondering, how is this David? How is this oral microbiome affecting the rest of my health? Yeah, what's it doing?   (15:40): Oh my goodness. Where to start? So we briefly discussed how the oral microbiome helps control blood pressure. Right? We talked about nitrate, but there's so many other ways. So one really big study that came out a few years ago showed that there's certain bacteria in your mouth that have actually been implicated in the progression of Alzheimer's disease. So this bacteria is called Pomona gingivalis. And since then there's been a lot of studies and looking at whether or not they can actually prevent Alzheimer's disease just by either killing these bacteria, removing them or blocking their activity. And companies have come up from this, just looking at Talis. So that's one way these bacteria, they end up in your brain somehow and then   (16:24): Any early data from any of those studies you can share or nothing yet.    (16:29): I think it's a little early, there was one clinical trial that had very early data that looked promising where they had. So Ponas, gingivalis creates this protein that cuts other proteins and this drug targets that protein, that cuts stuff. And they saw that. I think there was a mild decrease or a mild improvement in cognitive decline in patients with Alzheimer's disease by using a drug like this. But it was probably a very small study. And I think they're expanding that now.   (16:56): Okay, great. And then I cut you off cuz you were getting ready to talk about something else systemically.   (17:00): Yeah. The oral microbiome's been implicated in so many different things. So another big one is cancer, both in oral cancer and surprisingly colorectal cancer, which I guess is surprising to most people. But when you think about, you know, a hundred billion bacteria being swallowed every day, it becomes pretty obvious that there's this one bacteria called fuser bacterium nucle. And for some reason, this little bug is really, really good at causing inflammation. And what it does is it happens to be in very high abundance in people with tumors. It really likes the tumor environment. Why we don't really know why, but people have shown that people who have fus nucle in their tumors, those tumors grow a lot more aggressively. And the prognosis for those people is much worse than the people who don't have, have SLE.   (17:51): Okay. What about heart disease? You know, that's the number one killer of women over 50. Most women don't worry about it. Believe it or not. They're more worried about breast cancer, but they should be concerned about their hearts. How does the oral microbiome interact with the heart?   (18:07): Yeah. Park sees the number one killer in the United States. And there's actually a lot of interactions between the oral microbiome and the heart. Somehow bacteria in the mouth actually end up in the bloodstream. We don't really know how this happens, like a lot of things, but for instance, atherosclerotic plaque, the plaque that's high cholesterol and it builds up inside your arteries and, and can cause a blockage. People have found oral bacteria in there. They found Fusor bacteria, NLE, Pomona tr Tova a lot of these gum disease pathogens just happen to make it into the bloodstream. We think that the people who have gum disease, they're more susceptible to this happening because the gum disease actually causes damage to the gum tissue and allows them to invade and, and get into your bloodstream. But the mechanism for how this happens is still very unclear. There's also other bacteria in the mouth that can cause infecti endocarditis. It's a pretty rare condition, but somehow again, the bacteria in the mouth, they end up in the heart and they cause an infection.   (19:05): Interesting. So I'm curious, has anybody done any studies on longevity as it relates to the makeup of the oral microbiome?   (19:14): Nope. Not yet. Not   (19:16): Yet.   (19:17): Very good question. I wish we did. so I will say that people have looked at oral health in longevity, but not really the oral microbiome longevity, right? Like there's a very strong correlation between good oral health and longevity. Mm-Hmm because the people who can eat longer, eat solid foods or good foods for longer and to do better. And so it wouldn't be surprising if you found that the people that live longer have very healthy oral microbiomes because in order to have healthy teeth who need a healthy oral microbiome, but so far no study definitively.   (19:52): Okay. Interesting. I was just curious, and I know that at Bristol, you guys offer tests for the oral microbiome. Can you talk a little bit about what people could do to be proactive about assessing their oral biome and promoting a healthy oral biome?   (20:13): Yeah. First thing I always say is take a test because that's really the only way you can get data around it. So it's kind of like for instance, for diabetes, a lot of people don't know their status for diabetes. And the only way they know is by going get a blood test, and it's the same for oral health. You really don't know there's no lab tests or have there hadn't been any lab tests for oral health until bristle came along. And so you really need to get the data around it, to know what your starting point is to know what you need to improve because there's very specific recommendations we can make based on the makeup of your oral microbiome. So, I mean the first thing about being proactive is fix your diet brush twice a day, floss once a day, reduce your mouth breathing, try and eat more nitrate foods with nitrate in them. So there's leafy greens and let's see eat more arginine. If you can. Other than that, the recommendations we make could be for specific probiotics to help you improve your oral health. But we don't know which ones, unless you take a test.   (21:12): Okay. So on the test, what kind of information do you get?   (21:15): So we give a variety of scores that are based on your oral microbiome. Really. We look at all the bacteria in your mouth. Eventually we'll also report on the different viruses and fungi because we know that they're also really important for oral disease. But right now, if we're talking about just bacteria, you get scores for your cavities. So we tell you what kind of bacteria in your mouth can contribute to cavities. What kind of bacteria in your mouth can contribute to gum disease, which ones in the mouth that are also implicated in gut inflammation and bad breath. And we're adding, we're adding new features all the time. So,   (21:50): Okay. So it's not one where you're gonna get specific bacterial names. You're basically going to get some type of score. I'm looking at the sample report where you'll get a beneficial bacteria score. And then it will say how you stack up next to healthy people. You get a tooth case score and you'll be told how you stack up compared to people who are healthy people with tooth decay and you'll get a gum inflammation score. And you'll be told compared to people with inflammation, healthy people and you, and then also halitosis bad breath, you'll get a score. And then based on the results you'll get, excuse me, diet and hygiene tips. Is that right?   (22:31): More than that too. Okay. You'll get specific recommendations for probiotics, if possible, and different kinds of supplements that could help you and included in each of the scores. We also do give the bacteria names. We give your abundance of each of the bacteria and how you relate to other people for those different bacteria. And a lot of times it's really hard to interpret that kind of information. Like I can tell you that you have, you know, Pomona gingivalis, but what does that really mean for you? So we try to contextualize it into these scores.   (23:01): I see that I just have a basic, and then there is a breakout where it does show you your bacteria related to these different items and you get custom recommendations based on this. So I didn't see that before.   (23:14): Okay. And each test with the recommendations, we also provide a coach. So we have a dental hygienist on staff who is educated in the oral microbiome and what you can do to improve it. And we provide one coaching call to everyone who, who takes the test so that you can better understand how you can improve oral health, because we know that everybody is different. And so the recommendations we make may not entirely be applicable to you because you have a very specific need. And so we try to build around personalized medicine because we don't think there's a one size fits all approach for anybody really.   (23:46): Right. That's so true. And I love that you give a coaching appointment, they can go through that. I really think that in this day and age, where if you're trying to be proactive about your health and be as healthy as you can now and going forward in the future, this needs to be a part of your plan, right? Not just visiting the dentist twice a year and getting your teeth clean, not just brushing and flossing, but really assessing your oral microbiome as well as your colorectal microbiome and doing all the tests that I talk about. I say all the things, I really think this needs to be a part of it. How did you become interested in this topic? I always wanna know why people do what they've been.   (24:28): So I was trained as a scientist. I did my master's studying antibiotic resistance, so I studied bacteria. And then afterwards I wanted to do something different. I went to study a virus dengue virus during my PhD. And I decided, well, at the time I went to university of Michigan where there's a very big consortia of people studying the gut microbiome. And so the neighboring lab actually studies the interaction between the mouth and the gut. They use a lot of tools to look at how bacteria get from the mouth to the gut and whether or not they can cause disease. And so they published a few studies and that was kind of the start of my foray into it because I used to, we do a thing called journal club. It's basically research sharing between the different labs and, and that's where I first got interested. And so when I came back to California, where I grew up, I decided I wanted to study something with the microbiome. And what I decided to, to embark on was this very complicated interaction between the microbiome, the immune system and neurons. So neurons can interact with the immune system in the gut. And it's really important for actually maintaining homeostasis and keeping a healthy gut. But the way it happens is extremely complicated.    (25:45): Podcast level, like very,   (25:47): I'm not even sure I could explain it very well. Basically the summary at the time of me studying this was that neurons actually create proteins that help recruit immune cells. So there's different types of cells and the immune system that live within your tissue. So normally we refer to immune cells as in your blood and they help to monitor the, the health of your body. But some of them actually live inside of tissues and there's very specific. They're called macrophages. They can sample the environment, they eat stuff, and then they tell your body what's there. And it turns out that neurons, if you get rid of the neurons, then these macrophages also go away. And so these macrophages are in the gut and they're held there by neurons and they help to sample the environment of the gut to tell you, do you need to have diarrhea because there's something bad in here or are you okay because neurons also happen to control the motor function of the gut. So it's a very interesting interaction.   (26:45): Yes. So much science behind all of this. I think it's fascinating. I think what's important for everybody today to get the message. Is that the, or the bacteria in your mouth matter for your, the rest of your system matter for your brain health and do you get dementia or not matter for your heart and do you get heart disease or not matter for many aspects of your health and that to be proactive, you need to test not guess that's something I always say. And treat, I'm just wondering, it sounds like they've found association for instance, with certain of these pathogenic bacteria and hypertension, but have they proved causation and done any interventional studies to say that if you change these bacteria, then your blood pressure will improve. Yeah. Yes.   (27:33): , that's a really good question. That's so what people have done is they've introduced nitrate as a supplement in the mouth. And what they look at is two measurements. The first is salivary nitric oxide. So how much nitrate is being reduced in your saliva and how much nitrate is being reduced into your blood? And so a few studies have very small studies have gone into adding these supplements and it modulates the microbiome in a way that shifts towards more nitrate, reducing bacteria. And that in turn increases your nitric oxide in the blood. So not only have they done a depletion study, where they looked at the people who took mouthwash and it killed all the bacteria, mm-hmm, , they've also boosted them and saw a boost in the blood. Very   (28:15): Interesting. I love that. That is and Pally. We're just, this field is in its Macy and we're gonna have all kinds of designer, probiotics and treatments, hopefully for the mouth in the near future. I will look forward to that and we'll have in the show notes, a link to your blog, and then you do have a discount code for anybody who wants to order a test. So we'll have a code Kyrin, one 50, we'll have the link you can use in the show notes. If you're driving, please don't try to do it. Look it up now , we'll have the link in the show notes. We'll have the code Kyrin one 50 for 15% discount. And you can also look at a sample oral health test report. Like the one I was looking at we'll have the link for that. And I asked David before we started to share a couple quotes on life that he liked to with me. And, you know, I love a good quote. So they're all great, but I'm gonna share this one. Worrying is like a rocking chair. It gives you something to do, but it gets you nowhere.   (29:23): So are you not a worrier? you not worry at all? I   (29:27): Try not to be. I really try not to be. I really like this quote, cuz worrying is the same as doing nothing. Right? It's kind of like your test don't guess by worrying, you're really just sitting there and guessing you don't really know what's gonna happen. Why don't you go do something about it? Just go test, go find out.   (29:43): I love that. It is yeah. Test don't guess do something. It's just, it's rehearsing possibilities. And, but we can do it. I wonder if abnormal microbiome in your mouth is associated with increase in worrying. That would be an interesting study. David, you might wanna do that one. (29:58): There were a few that had suggested some mental health issues were associated with oral microbiome changes. So there was depression, schizophrenia. Alzheimer's like we just talked about a number of things. Yeah.   (30:10): That is fascinating. I think there's gonna be way more data coming out on this association. I mean, we've got the vagi biome. We have our ocular biome. We've got them all over.   (30:22): We didn't even talk about the vaginal microbiome, the oral microbiome, the same bacteria that cause bacterial VA happen to be the ones that are in the mouth that cause gum disease.   (30:31): How fascinating, who knew? Do you guys offer any testing for that?   (30:37): So the, we do have a report on the bacteria. We don't call them out explicitly, but I think one of the, one of the scores we'll probably add in the future will be something like that will be a vaginal dysbiosis score because there's been a few studies that have shown the same strains of bacteria in the mouth. They actually end up colonizing the gut and then in turn, they end up in the vagina. Right. And so if you have dysbiosis either in your gut or in your mouth, that could definitely translate down to the vagina too.   (31:07): Fascinating. So fascinating. David Lin, thank you so much for coming on the hormone prescription podcast and sharing this information with us. I very much appreciate it.   (31:19): Absolutely likewise, me too.   (31:22): And thank you all for listening to another episode of the hormone prescription with Dr. Kyrin. Hopefully you've heard something today that you'll take and put into action to improve your health. It's great to have education atta, but ultimately what's gonna make an impact on your health and your life are the actions that you take. So go check out David's blog, maybe order a test kit, do the test, get the information, take action. And remember if you wanna mouth tape, read about how to do it properly first and I will see you next week. Thanks so much for joining me until then peace, love and hormones.   (32:02): Y'all thank you so much for listening. I know that incredible vitality occurs for women over 40. When we learn to speak hormone and balance these vital regulators to create the health and the life that we deserve. If you're enjoying this podcast, I'd love it. If you give me a review and subscribe, it really does help this podcast out so much. You can visit the hormone prescription.com, where we have some free gifts for you and you can sign up to have a hormone evaluation with me on the podcast to gain clarity into your personal situation until next time, remember, take small steps each day to balance your hormones and watch the wonderful changes in your health that begin to unfold for you. Talk to you soon.   ► The Oral Health Test Kit Measure the 100+ bacteria in your saliva that contribute to tooth decay, gum inflammation, and halitosis (bad breath). https://www.bristlehealth.com/product-oral-health-test - Use the code (KYRIN150 at checkout to get 15% discount)   ► Understand, measure, and improve your oral health. Get your Sample Oral Health Test Report: CLICK HERE   ► Feeling tired? Can't seem to lose weight, no matter how hard you try? It might be time to check your hormones.   Most people don't even know that their hormones could be the culprit behind their problems. But at Her Hormone Club, we specialize in hormone testing and treatment. We can help you figure out what's going on with your hormones and get you back on track.   We offer advanced hormone testing and treatment from Board Certified Practitioners, so you can feel confident that you're getting the best possible care. Plus, our convenient online consultation process makes it easy to get started.   Try Her Hormone Club for 30 days and see how it can help you feel better than before.   CLICK HERE to sign up.  

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners!

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners!

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners!

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners!

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners!

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners!

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners!

Season 2 Episode #33 with Dr. Rick Chromey coming from Star, IdahoYou can find our guest via his website rickchromey.comDr. Rick Chromey is a cultural explorer, social historian, generational futurist and international keynote speaker. A best-selling author, he has penned over a dozen books on leadership, natural motivation, creative communication, and classroom management. His most recent work, GenTech: An American Story of Technology, Change, and Who We REALLY Are is now available online and in bookstores everywhere. His book is an engaging romp that explores why labeling people with terms like “Baby Boomer” or "Gen X" or “Millennial” or "Gen Z" just doesn't work!Rather, Dr. Chromey explores the technology we encounter between the ages of 10 and 25 (our "coming of age" years). This technological frame better helps leaders, teachers and parents to understand where we all fit and the assets we bring into the boardroom, classroom or home.Rick has served as a pastor, professor, speaker/trainer, and consultant, working in the nonprofit and corporate sectors. In 2017, he founded MANNA! Educational Services International to inspire and equip leaders, teachers, pastors, and parents. Rick holds a doctorate in leadership and emerging culture; and travels the U.S. and world to speak on culture, faith, history, education, and leadership topics.Rick, thanks for dedicating your life's work to helping people grow into their best selves.  Rick, Welcome to the show!TOTD – “Without the recognition of the soul's journey within us, we are lost and only part of what we were intended to be.”  Shirley MaclaineIn this episode:What was life like growing up?What is the best thing you do for yourself?Have to talk about your alternate career of being a PICKER.  I love the show American Pickers and find myself fascinated with history and appreciation of the story of something old…Tell us some stories of your collection…Importance of ministry and developing our youth - How technology is changing humanity?Classroom management – specifically engaging the learner…Leadership and motivationFaithLet's talk about your book – GenTech.  How did you come up with the idea and the message?Legacy - What is it you want people to feel when you are no longer in their presence?Thanks for listening and enjoy the show.Please click on the link below to download GenTech for free.   Thanks Rick! Get your free DIGITAL copy of Rick's book (GenTech: An American Story of Technology, Change and Who We Really Are):  https://dl.bookfunnel.com/37oz433xx9 

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners!

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners! ⭐ Introducing Shannon Murphy, Founder of The Tampa Guide ⭐ In this episode, we discuss the importance of having a pure passion for your business or startup, consistency being key, and the importance of personal branding. Also the power of starting NOW! Learn how to become a successful business owner and more on our podcast! Youtube Link: https://youtu.be/68us-Lr0GII @TheTampaGuide @heygirlitzshanman ▬ Social Media ▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬ ► Facebook: https://www.facebook.com/gentechmarke​... ► Instagram: https://www.instagram.com/gentechmark​... ► Website: https://www.gentechmarketing.com

Dr. Rick Chromey a cultural explorer, social historian and generational futurist, uses historical insight and cultural inspiration to empower audiences to rethink and reimagine how they lead, teach, pastor and parent. Rick believes "one thing all generations experience together is technological change."Rick has a doctorate in leadership and the emerging culture; and travels the U.S. and world to speak on culture, faith, history, education, and leadership topics.He has served as a pastor, professor, speaker/trainer, and consultant. In 2017, he founded MANNA! Educational Services International to inspire and equip leaders, teachers, pastors, and parents. He shares over 30 years of training experience.Get your free DIGITAL copy of Rick's book (GenTech: An American Story of Technology, Change and Who We Really Are :  https://dl.bookfunnel.com/37oz433xx9 We are a product of certain technologies that shape us between our tenth and twenty-fifth birthdays. It's a blending of “generation” and “technology.” This topic makes you think. https://www.facebook.com/rickchromeyspeaker/videos/220309979318082Website, https://rickchromey.com/Instagram, https://www.instagram.com/rickchromey/LinkedIn, https://www.linkedin.com/in/rickchromey/Facebook, https://www.facebook.com/rickchromeyspeakerTwitter, https://twitter.com/Dr_Rick_ChromeyTwitter, https://twitter.com/MyGenTech2020YouTube, https://www.youtube.com/channel/UCoXjDFeB-2ZcQmsOeISJq-AFounder and President MANNA! Educational Services Int'l - faith-based nonprofit http://www.mannasolutions.org#GenTech #MANNA #DrRickChromey #OnlineForAuthors #VisibilityPod #JenniferPalmer#HAIRTechnology #Generations #StraussHowe #Millennials #iTech*************************************************************************************100 Podcasts in 100 Days – Take the Podcast Mastery Challenge https://podcasting.endlessstages.com/?fpr=jennifer70 #SpeakingChallengePodMatch – PodMatch Automatically Matches Ideal Podcast Hosts And Guests For Interviews https://podmatch.com/signup/onlineforauthors #podmatchRepurpose.io – Reach more people with your content using this easy-to-use automation platform to grow your online presence VisibilityPod Hosted event July 21, 2002*Copyright owned by OnlineForAuUnder Management with VisibilityPod End MatterSupport the show

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners! ⭐ Introducing CJ Rothwell Thompson, Founder and CEO of Booze and Bubbles in Tampa, FL ⭐ In this episode, we discuss the importance of being able to adapt to your environment, collaborating with local businesses to expand their markets, and giving a little to get a lot when it comes to starting a business. Learn how to become a successful business owner and more on our podcast! Youtube Link: https://youtu.be/5nsG4l5ZPwg Booze And Bubbles Instagram - www.instagram.com/boozeandbubbless/ ▬ Social Media ▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬ ► Facebook: https://www.facebook.com/gentechmarke​... ► Instagram: https://www.instagram.com/gentechmark​... ► Website: https://www.gentechmarketing.com

1.Blashear - Rooting 2.System F - Cry (Lucas Deyong remix) 3.Bryan Kearney - Something out of nothing 4.Giuseppe Ottaviani - Spellbound 5.Sean Tyas - Mantra 6.Plastic Boy - Live another life (Astreriod 2020 remix) 7.Veracocha - Carte Blanche (Jay Flynn remix) 8.Craig Connelly - Amnesia 9.UCast - It's a trap 10.Bedrock - Heavenscent (Greg Downey remix) 11.DK8 Vs RVD Vs Prodigy - Murder was the no good renagade 12.BK - Revolution (Ryan K rework) 13.The Prodigy - We live forever (Gentech's dreamstate remix) 14.Sneijder - #Acid 15.Mike Oldfield - Tubular bells (Paul Denton rework) 16.David Forbes & David Nimmo - That's the way i like it 17.Iain M - Synthetic Life 18.David Nimmo - What goes up must come down

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners! Introducing Jake Kurtz, Founder and CEO of Brick Media in Tampa, FL. We discuss Jake's 2 step process to stay top of mind, how social media platforms are aging and adjusting, and the importance of keeping up with social media trends and updates! Learn how to become a successful business owner and more on our podcast! ------------ ► Youtube Link: https://youtu.be/fOCczIh-RJc ► Jake Kurtz Instagram - https://www.instagram.com/iamjakekurtz/ ► Brick Media Instagram - https://www.instagram.com/brick_media/ ▬ Social Media ▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬ ► Facebook: https://www.facebook.com/gentechmarke​... ► Instagram: https://www.instagram.com/gentechmark​... ► Website: https://www.gentechmarketing.com

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners! In this episode, we speak with Madison Masterson, Founder and CEO of Mad Marketing in Tampa, FL. We discuss the importance of outsourcing, how to put a value to your time, the toxicity of social media and more! Madison also gives us the guide to being a successful social media influencer in this saturated industry! Learn how to become a successful business owner and more on our podcast! Youtube Link: https://youtu.be/0ZGHdgLi7XY Madison Masterson Instagram - www.instagram.com/madisonmmusic/ ▬ Social Media ▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬ ► Facebook: https://www.facebook.com/gentechmarke​... ► Instagram: https://www.instagram.com/gentechmark​... ► Website: https://www.gentechmarketing.com

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners! In this episode, we speak with Dr. Connor Oliveri, Founder and CEO of Elevate Health. We discuss the importance of taking risks at the beginning of your career, investing in yourself and your dream, and the impact of health and wellness. Along with how Dr. Oliveri uses social media, ambassadors, and giveaways to grow his business. Learn how to become a successful business owner and more on our podcast! Youtube Link: https://youtu.be/McmuXgqMDO0 Dr. Connor Oliveri IG - https://www.instagram.com/dr.oliveri/ Elevated Health IG - https://www.instagram.com/elevateheal... ▬ Social Media ▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬ ► Facebook: https://www.facebook.com/gentechmarke​... ► Instagram: https://www.instagram.com/gentechmark​... ► Website: https://www.gentechmarketing.com

Welcome back to the GenTech Podcast, bringing you valuable and inspirational discussions with the top business owners! In this episode, we speak with Sam Coscia, Founder and CEO of Sammy Swim. We discuss the importance of influencer marketing, being true to your brand, and her company going viral on TikTok! As a young female business owner, we also speak with Sam about how she balances school and work and her advice to other aspiring entrepreneurs. Learn about the importance of influencer marketing, how to become a successful business owner and more in this podcast! Youtube Link to Podcast: https://youtu.be/I_-vcMvJNnk Samantha Coscia IG - https://www.instagram.com/samcoscia/ Sammy Swim Co IG - https://www.instagram.com/sammyswimco/ ▬ Social Media ▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬ ► Facebook: https://www.facebook.com/gentechmarke​... ► Instagram: https://www.instagram.com/gentechmark​... ► Website: https://www.gentechmarketing.com

Die EU-Kommission will Eier einer gentechnisch veränderten Legehennenlinie ohne Risikoprüfung zulassen. Israelische Forschung macht's möglich: Es schlüpfen nur noch die für die Eierproduktion nötigen Weibchen. Dafür ist bei den Eltern der Tiere das Genom verändert worden. Die Herstellerfirma NRS Poultry wirbt damit, „Humanität und Nachhaltigkeit in die Produktion der wichtigsten Protein-Ressource der Welt“ zu bringen,Weiterlesen

Dr. Chromey is a best-selling author, international speaker, cultural historian, professor, and pastor. His mission is to help people interpret history, navigate culture and explore faith to create trusted and transformative change. He's authored over a dozen books, including his most recent work titled “GenTech: An American Story of Technology, Change and Who We Really Are” (2020). http://www.rickchromey.com/ http://www.mannasolutions.org

In this episode, Robert Fojo welcomes Dr. Rick Chromey, a cultural historian, leadership professor, and inspirational speaker.  Dr. Chromey is also the author of GenTech: An American Story of Technology, Change and Who We Really Are, a book in which he offers a fresh perspective for understanding what makes a generation tick and differ from others.  Their discussion covers a variety of topics, including GenTech, modern-day politics, conservatism, Donald Trump, Ron DeSantis, Hunter Biden's laptop, American history, the influence of technology on recent generations, and how social media platforms are impacting modern-day opinions and social discourse.  For a limited time, listeners can grab a free copy of Dr. Chromey's book at this link: https://dl.bookfunnel.com/37oz433xx9 

Als die Dinosaurier ausstarben, machten sie den Säugetieren Platz. Diese legten zuerst an Grösse und Masse zu. Erst später investierten sie in grössere Gehirne. Und: Konsequente Kreislaufwirtschaft ist nicht immer das Beste für die Umwelt. Ausserdem: Gentech 2.0 für den Acker. (0:50) Evolution Säugetiere sind die Intelligenzbestien der Tierwelt. Das Gehirn eines Pottwals, das grösste auf der Erde, wiegt zwischen acht und neun Kilo. Doch wie sind Säugetiere zu so viel Hirnschmalz gekommen? Eine «Science»-Studie hat dies anhand neu entdeckter Fossilien untersucht. (6:50) Meldungen - Zähe Verhandlungen für ein Biodiversitäts-Abkommen - Eisvulkane auf Zwergplanet Pluto - Humor in der Wissenschaft (14:50) Gentech für den Acker Weltweit arbeiten Forscherinnen und Firmen daran, Ackerpflanzen mit der exakten Genschere Crispr zu verbessern und sie auf die Felder zu bringen. Wir erklären, warum, wie, wo, was und ordnen ein: Was kann man davon erwarten und wo steht man in der Schweiz, wo nach wie vor ein Gentech-Moratorium gilt? (22:35) Nachhaltige Wirtschaft Die Wirtschaft muss umweltfreundlicher werden, um die Natur und unsere Lebensgrundlagen vor weiterer Zerstörung zu bewahren. Erreicht werden soll dies durch die so genannte Kreislaufwirtschaft. Doch es lauern Tücken.

This week we have a special episode for you!