Podcasts about cerebrospinal

Self Created Valuation Boosts Apple Announces new Podcast push AI – A breakdown Playing them like a fiddle – Warner Brothers PLUS we are now on Spotify and Amazon Music/Podcasts! Click HERE for Show Notes and Links DHUnplugged is now streaming live - with listener chat. Click on link on the right sidebar. Love the Show? Then how about a Donation? Follow John C. Dvorak on Twitter Follow Andrew Horowitz on Twitter Warm-Up - A NEW CTP just announced - China releasing new AI models - AI - A breakdown - we are on overload - Big Employment news.... Markets - Self Created Valuation Boosts - Apple Announces new Podcast push - Playing them like a fiddle - Warner Brothers Quick Note - Going to rip up the playbook on something this week on TDI Podcast. Anyone who owns an annuity should listen to what is about to come on next Sundays show.....  No Agenda... Olympics - Anything to discuss? MONEY FOR ALL - The average tax refund is 10.9% higher so far this season, compared to about the same point in 2025, according to early filing data from the IRS. - The 2026 tax season opened Jan. 26, and the average refund amount was $2,290 as of Feb. 6, up from $2,065 about one year prior, the IRS reported Friday night. - As of Feb. 6, the total amount refunded was more than $16.9 billion, up 1.9% compared to last year, according to the IRS release. That figure reflects current-year returns only. - This is partly because there were excess-witholdings from last year on the rules changed and paycheck withholdings were not adjusted. This is a one time situation.. Emplyment - 4.3% - "Better" than expected payrolls number - A major revision was released last Wednesday. Overall 2025 job growth was much weaker than initially reported. The total net change for the full year 2025 was revised down from +584,000 jobs to just +181,000 jobs (seasonally adjusted) — an average of only about 15,000 jobs added per month instead of ~49,000. This made 2025 one of the weakest years for job creation in recent non-recession periods. - Employment levels were consistently overstated throughout 2025 by roughly 800,000 to over 1 million jobs, peaking around mid-year. For example: By March 2025, the level was revised down by 898,000. By December 2025 (preliminary), down by 1,029,000. - Monthly changes were also adjusted downward in most cases (e.g., August's originally reported -26,000 became a larger loss of -70,000; September's +108,000 became +76,000). - The revisions reflect normal annual benchmarking, but this one was unusually large (larger than the typical 0.2% average over the prior decade), likely due to factors like overestimation of business births or other data mismatches. - In short, the data reveals that the U.S. labor market in 2025 was significantly softer than the monthly headlines suggested at the time — job growth was overstated by a substantial margin, painting a picture of a much weaker employment picture for the year. AI Updates - While U.S. markets have been focused on the impact of Anthropic and Altruist's tools on software and financial services, China's tech giants have released AI models this week that have shown advancements in robotics and video generation. - Google is reporting that China's AI models are just MONTHS behind western models - However - is this progress? In a video demo, Alibaba showed a robot with pincers for hands that appeared to be able to count oranges, pick them up and place them in a basket. It was also shown taking milk out of a fridge. - Alibaba on Monday unveiled a new artificial intelligence model Qwen 3.5 designed to execute complex tasks independently, with big improvements in performance and cost that the Chinese tech giant claims beat major U.S. rival models on several benchmarks. - Zhipu AI — which trades as Knowledge Atlas Technology in Hong Kong said the model approaches Anthropic's Claude Opus 4.5 in coding benchmarks while surpassing Google's Gemini 3 Pro on some tests. - Shares of MiniMax also jumped Thursday after it launched its updated M2.5 open-source model with enhanced AI agent tools. Grok Update - Grok, Elon Musk's AI chatbot, has been gaining ground in the U.S. over the past months, data showed, even as it draws global censure and regulatory scrutiny after being used to generate a wave of non-consensual sexualized images of women and minors. - U.S. market share of the tool rose to 17.8% last month from 14% in December, and 1.9% in January 2025, according to data from research firm Apptopia. - Men are still the largest % users of Grok ~ 78% (down from 89% in April 2025) AI Market Share - ChatGPT's share slumped to 52.9% last month from 80.9% in January last year, while Gemini's grew to 29.4% from 17.3% over the same period. AI Market Share InfoGrapic and AI Understanding - Have we gone through this? - At its core, AI is technology that lets machines perform tasks that normally require human intelligence — things like understanding language, recognizing images, making decisions, or solving problems. - Modern AI (especially since ~2022) is dominated by machine learning — systems that learn patterns from huge amounts of data instead of being explicitly programmed rule-by-rule. - Inference is the "using" or "applying" phase of AI — when a trained model takes new input and produces an output / prediction / answer. Contrast with training (the "learning" phase): ------ Training ? Like a student studying for years: very compute-heavy, expensive, done once (or rarely) on massive servers/GPUs, adjusts billions of parameters based on examples. ------ Inference ? Like the student taking a test or doing their job: much faster, cheaper, runs on your phone/laptop/cloud, uses the fixed knowledge from training to respond instantly. - gentic AI takes regular AI (like chat models) to the next level: instead of just answering questions or generating text, these systems act autonomously to achieve goals with minimal human help. "Agentic" comes from "agency" — the ability to make decisions, plan, use tools, take actions, adapt, and even learn from results — like a smart digital employee rather than just a smart answer machine. AI Infographic Last AI Item - A shortage of memory chips is hammering profits, derailing corporate plans, and inflating price tags on various products, with the crunch expected to get worse. - The fundamental reason for the squeeze is the buildout of AI data centers, with companies like Alphabet and OpenAI buying up large shares of memory chip production, leaving consumer electronics producers fighting over a dwindling supply. - The resulting price spikes are causing concern, with some warning of "RAMmageddon" and others predicting that memory chip prices will go "parabolic", bringing lavish profits to some companies but painful prices to the rest of the electronics sector. Here is something: - Gallup will no longer track presidential approval ratings after nearly 90 years - Founded by George Gallup in 1935, the Washington, DC-based management company began tracking the president's job performance 88 years ago. - Gallup told USA TODAY it will no longer publish "favorability ratings of political figures," a decision it said "reflects an evolution in how Gallup focuses its public research and thought leadership." - Gallup said the ratings are now "widely produced, aggregated and interpreted, and no longer represent an area where Gallup can make its most distinctive contribution." - "Our commitment is to long-term, methodologically sound research on issues and conditions that shape people's lives," the company wrote, adding that its work will continue through the Gallup Poll Social Series, the Gallup Quarterly Business Review, the World Poll and more. - Seems like they are unable to SHAPE opinion due to social media etc.....? Apple Podcast Update - Big news! - Apple on Monday announced that it will bring a new integrated video podcast experience to Apple Podcasts this spring. - The move comes as video viewership continues to reshape podcasting. About 37% of people over age 12 watch video podcasts monthly, according to Edison Research. - The update brings Apple Podcasts more in-line with its competitors Spotify, YouTube and now Netflix, which have increasingly leaned into video podcasting. -“Twenty years ago, Apple helped take podcasting mainstream by adding podcasts to iTunes, and more than a decade ago, we introduced the dedicated Apple Podcasts app,” said Eddy Cue, Apple's senior vice president of Services, in a statement. “ - By bringing a category-leading video experience to Apple Podcasts, we're putting creators in full control of their content and how they build their businesses, while making it easier than ever for audiences to listen to or watch podcasts.” M&A - Texas Instruments Inc. has reached an agreement to buy Silicon Laboratories Inc. for about $7.5 billion, deepening its exposure to several markets for chips. - Silicon Labs investors will receive $231 in cash for each share of the company's common stock and the transaction is expected to close in the first half of 2027. - The transaction still needs to win approval by investors in Silicon Labs and shares of Silicon Labs surged by 51% to $206.48 after the announcement. Inflation - This helps - PepsiCo, will cut prices on core brands such as Lay's and Doritos by up to 15% following a consumer backlash against several previous price hikes, the snacks and beverage maker said on Tuesday after it topped fourth-quarter results. Miran - Moving - Federal Reserve Governor Stephen Miran is leaving his post as chair of the Council of Economic Advisers, CNBC has confirmed. - He joined the CEA in January 2025, but had been on leave from that post since last September when he filled the unexpired term of former Fed Governor Adriana Kugler.- He reamins on Fed board No Biggie???? - There are some astonishing cased being reported of Bad AI in the operating room - JNJ's TruDi Navigation System - Since AI was added to the device, the FDA has received unconfirmed reports of at least 100 malfunctions and adverse events. - At least 10 people were injured between late 2021 and November 2025, according to the reports. Most allegedly involved errors in which the TruDi Navigation System misinformed surgeons about the location of their instruments while they were using them inside patients' heads during operations. - Cerebrospinal fluid reportedly leaked from one patient's nose. In another reported case, a surgeon mistakenly punctured the base of a patient's skull. In two other cases, patients each allegedly suffered strokes after a major artery was accidentally injured. Cuba - The main airport has putt out a bulletin that they are out of Jet Fuel - Blackouts and lack of other fuels are creating big problems - No airlines have stopped running at this point, but many will as they cannot refuel - This is a bigger problem for cargo planes (supplies) that may not be able to risk flying to Cuba as they will not be able to get out. Dalio Warning -  Legendary investor Ray Dalio said on Tuesday the world was “on the brink” of a capital war. - He said central banks and sovereign wealth funds were already preparing for measures like foreign exchange and capital controls. - "When money is weaponized using measures like trade embargoes, blocking access to capital markets, or using ownership of debt as leverage." - “Capital, money, matters,” Dalio said Tuesday. “We're seeing capital controls … taking place all over the world today, and who will experience that is questionable. So, we are on the brink — that doesn't mean we are in [a capital war now], but it means that it's a logical concern.” - Could this be why gold and siver are being hoarded (physical assets over digital currency? - Is China's edict to banks to diversify away from US Treasuries a sign? Self Boosted Valuation - Waymo is aiming to raise about $16 billion in a financing-round that would value it at nearly $110 billion, Bloomberg News reported, citing people familiar with the matter. - Alphabet would provide about $13 billion to the autonomous driving firm while the rest would come from investors including Sequoia Capital, DST Global and Dragoneer Investment Group, the report added. - Soooooo - Waymo is a unit of Alphabet.... Alphabet providing 80% of the funding that boosts valuations..... Hmmmmmmmm Warner Brothers -  Warner Bros Discovery Inc is considering reopening sale talks with Paramount Skydance Corp after receiving its amended offer. - The Warner Bros board is discussing whether Paramount could offer a path to a superior deal, which may ignite a second bidding war with Netflix Inc. - Paramount submitted amended terms that addressed several concerns, including covering a fee owed to Netflix and offering to backstop a Warner Bros debt refinancing. Economics Coming Up - Short Week - plenty of Reports - Wednesday - Durable Goods, Housing Starts, Industrial Production, FOMC Minutes - Thursday - Philly Fed, Initial Claims - Friday: PCE, Personal Income and Spending, GDP for Q4 (3.6%) ----- New Home Sales, UMich Feb Final   Love the Show? Then how about a Donation? ANNOUNCING THE THE CLOSEST TO THE PIN for CATERPILLAR Winners will be getting great stuff like the new "OFFICIAL" DHUnplugged Shirt!     FED AND CRYPTO LIMERICKS   See this week's stock picks HERE Follow John C. Dvorak on Twitter Follow Andrew Horowitz on Twitter

Silver, Gold and Crypto (oh my) Hang on – Wild ride here Superbowl, Olympics- Wait until you hear about the CAPex spending! Shakeup in Dietville PLUS we are now on Spotify and Amazon Music/Podcasts! Click HERE for Show Notes and Links DHUnplugged is now streaming live - with listener chat. Click on link on the right sidebar. Love the Show? Then how about a Donation? Follow John C. Dvorak on Twitter Follow Andrew Horowitz on Twitter Interactive Brokers  Warm-Up - Silver, Gold and Crypto (oh my) - Need a stock for CTP - Hang on - Wild ride here - Superbowl, Olympics- Wait until you hear about the CAPex spending! - Shakeup in Dietville Markets - Massive moved during the week - - Bitcoin clipped $60k before rebounding - DJIA tops 50,000 for the first time - Wait until you hear about the CAPex spending! - CAT == 1,100 points on the DJIA in 2026 Superbowl and Superbowl ads - Game review - Any ad stick out? - $10M per ad this year - Half Time with Bad Bunny? - Anthropic busting on OpenAi Last Week! - Massive moved - quick calc showed that about $1T was wiped from market caps in the sell-off, particularly in tech names. - HOWEVER - Friday alone is estimated to have added $1.5T to market cap AI Ripping Through - Plenty of names getting cooked over AI announcements - First it was the software companies - Now there are names in legal and finance that got clocked - Today - Altruist.ai can do tax planning and that hurt companies in financial space Earnings Season Update - Reporting so far: 59% of S&P 500 companies have reported Q4 2025 results. - Beat rate: 76% have topped EPS estimates (vs. 5-yr average: 78% (slightly lower) vs. 10-yr average: 76% (in line) - Magnitude of beats (aggregate): earnings are 7.6% above estimates vs. 5-yr average: 7.7% (about the same) vs. 10-yr average: 7.0% (a bit better) - Nothing great,  like Goldilocks Earnings Highlights - Palantir (PLTR): Reported strong Q4 results early in the week , beating estimates with revenue ~$1.41B (vs. ~$1.33B expected) and EPS $0.25 (vs. $0.23). Guidance for 2026 was upbeat (~61% revenue growth). Shares rallied sharply initially (~7–11% post-earnings), but gave back some gains amid broader tech volatility (e.g., down ~11–22% in parts of the week from peaks). - AMD: Reported mid-week, beating EPS (~$1.53 vs. lower expectations) with solid data center growth (~39%). However, Q1 guidance disappointed relative to high expectations in the AI chip space. Shares sank dramatically — down ~15–17% the next day, with some reports noting up to 20%+ drops at points, contributing to broader chip sector pressure. - Alphabet (GOOGL/GOOG): Reported beating on revenue (~$113.8B) and EPS (~$2.82), with strong core performance. But capex guidance for 2026 ($175–$185B, roughly double prior levels) sparked AI spending worries. Shares dipped post-earnings (down ~0.5–5% initially, flat to lower the next day, with some volatility pulling it below key moving averages). - Amazon (AMZN): Reported after hours on February 5, with mixed results — EPS ~$1.95 (narrow miss vs. ~$1.97 expected), but solid overall. The big negative was a surprise $200B capex forecast for 2026 (well above expectations), tied to AI/cloud buildout. Shares plunged sharply — down ~7–10% in after-hours/extended trading, with Friday moves around -5–8% in some sessions. Recent Tech CAPEX announcements - Amazon (AMZN) — Guided to approximately $200 billion in capex for 2026 (a massive jump from ~$125–131 billion in 2025, with ~80% likely AI-related per analyst commentary). This was the largest single-company figure and a major surprise, contributing heavily to the week's "wild" reactions. - Alphabet (GOOGL/GOOG) — Guided to $175–185 billion in capex for 2026 (roughly double the $91 billion spent in 2025, far above analyst expectations of ~$115–119 billion). Emphasis was on AI compute capacity, servers, data centers, and networking to meet demand for Gemini and cloud services. - Meta Platforms (META) — Guidance from late January (but heavily discussed last week): $115–135 billion for 2026 (up significantly from ~$70–72 billion in 2025, potentially an ~87% increase). - Microsoft (MSFT) — No new full explicit 2026 guidance in early February (fiscal year runs July–June), but recent quarterly run-rate and analyst projections put it around $97–145 billion (with some sources citing ~$105 billion or higher based on Q2 spending trends and signals of continued growth from prior levels of ~$88 billion in FY2025). ------!!!!Combined 2026 capex projected at $635–665 billion (low/high ends) or up to $650–700 billion in some reports — a ~60–74% increase from their collective ~$381 billion in 2025. Market Reaction from all of this.... - Markets were a bit spooked on the Anthropic announcement earlier in the week - software sold off and set a sour mood - Microsoft dumped pretty hard as the amount of spend was higher than anticipated, especially with some slower growth in Azure. - Amazon took a beating on the increased spend they anticipate *(extra by $50B) - BUT: Friday markets rallied as there was realization that the $200B spend by Amazon would seep into the economy and fuel infrastructure spending along with chips, tech etc. Other Earnings of Interest -  Reddit reported fourth-quarter earnings on Thursday in which the social media company beat on the top and bottom lines. - The company said it expects first-quarter sales to come in the range of $595 million to $605 million, which is higher than Wall Street expectations of $577 million. - Reddit also announced a $1 billion share repurchase program. - Reddit gets about $250 million a year from OpenAi and Google to have your data for training their LLMs While we are on the subject - Friday, DJIA hit 50,000 - first time ever! - Up 1,200 point of which approx 350 was from caterpillar and 280 was from Goldman Sachs Hats off to WalMart - Walmart Inc. shares pushed its market capitalization past $1 trillion on Tuesday for the first time ever| - Big transformation over the pst year - Walmart has maintained its appeal to households looking for value, its online offerings are drawing new, wealthier shoppers seeking convenience. Google Bond Offering - Issuing several tranches of bonds, denominated in Stirling - one as long as 100 years - Would you buy that? - The Google parent is set to raise $20 billion from a US dollar bond offering on Monday — more than the $15 billion initially expected — and is also pitching investors on what would be its first ever offerings in Switzerland and the UK. - The latter would include a rare sale of 100-year bonds, the first time a tech company has tried such an offering since the dotcom frenzy of the late 1990s Fat Profits in Dietville - Really interesting sequence of events happening... - Hims launches compounded pill at prices as low as $49 per month - Analysts cite questions on efficacy, legality of pill - Hims' move shifts focus from Novo's strong Wegovy pill launch - Broader obesity market whipsawed as pricing pressure rises THEN.. - Hims and Hers Health shares dive 14% after hours on Friday (Down 25% on Monday) - FDA cites concerns over quality, safety, federal law - The U.S. Food and Drug Administration said on Friday it would take action against telehealth provider Hims & Hers, for its $49 weight-loss pill, including restricting access to the drug's ingredients and referring the company to the Department of Justice for potential violations of federal law. AND.... - Eli Lilly last Wednesday posted fourth-quarter earnings and revenue and 2026 guidance that blew past estimates, as demand for its blockbuster weight loss drug Zepbound and diabetes treatment Mounjaro soars. - The pharmaceutical giant anticipates its 2026 revenue will come in between $80 billion and $83 billion. Analysts expected revenue of $77.62 billion, according to LSEG. - Meanwhile, NOVO had a really bad outlook that took the shares down 13% after the report. Japan Markets Soar - Japanese stocks jumped to a record high Monday, leading gains in the region after Prime Minister Sanae Takaichi won a landmark election victory. - The ruling Liberal Democratic Party captured a two-thirds supermajority in the 465-seat lower house, public broadcaster NHK reported. - Japan's Nikkei 225 jumped past 57,000 for the first time before paring gains to close 3.9% higher at 56,363.94, while the Topix also notched a record high, closing at 3,783.94, up 2.3%. Employment Report? - Government shutdown is forcing them to postpone again (Which is dumb) - Number due this Wednesday - Maybe because of this:U.S. employers announced 108,435 layoffs for the month, up 118% from the same period a year ago and 205% from December 2025. The total marked the highest for any January since 2009. - At the same time, companies announced just 5,306 new hires, also the lowest January since 2009, which is when Challenger, Gray & Christmas began tracking such data. - Also, job openings fell sharply in December to 6.54 million, to their lowest since September 2020. - Available jobs are down by more than 900,000 just since October. - NO! Ai and advancements in tech have noting to do with this! NO NO NO M&A - Texas Instruments Inc. has reached an agreement to buy Silicon Laboratories Inc. for about $7.5 billion, deepening its exposure to several markets for chips. - Silicon Labs investors will receive $231 in cash for each share of the company's common stock and the transaction is expected to close in the first half of 2027. - The transaction still needs to win approval by investors in Silicon Labs and shares of Silicon Labs surged by 51% to $206.48 after the announcement. Inflation - This helps - PepsiCo (PEP.O), opens new tab will cut prices on core brands such as Lay's and Doritos by up to 15% following a consumer backlash against several previous price hikes, the snacks and beverage maker said on Tuesday after it topped fourth-quarter results. Miran - Moving - Federal Reserve Governor Stephen Miran is leaving his post as chair of the Council of Economic Advisers, CNBC has confirmed. - He joined the CEA in January 2025, but had been on leave from that post since last September when he filled the unexpired term of former Fed Governor Adriana Kugler.- He reamins on Fed board No Biggie???? - There are some astonishing cased being reported of Bad AI in the operating room - JNJ's TruDi Navigation System - Since AI was added to the device, the FDA has received unconfirmed reports of at least 100 malfunctions and adverse events. - At least 10 people were injured between late 2021 and November 2025, according to the reports. Most allegedly involved errors in which the TruDi Navigation System misinformed surgeons about the location of their instruments while they were using them inside patients' heads during operations. - Cerebrospinal fluid reportedly leaked from one patient's nose. In another reported case, a surgeon mistakenly punctured the base of a patient's skull. In two other cases, patients each allegedly suffered strokes after a major artery was accidentally injured. Cuba - The main airport has putt out a bulletin that they are out of Jet Fuel - Blackouts and lack of other fuels are creating big problems - No airlines have stopped running at this point, but many will as they cannot refuel - This is a bigger problem for cargo planes (supplies) that may not be able to risk flying to Cuba as they will not be able to get out. Love the Show? Then how about a Donation? ANNOUNCING THE WINNER OF THE THE CLOSEST TO THE PIN CUP 2025 Winners will be getting great stuff like the new "OFFICIAL" DHUnplugged Shirt!     FED AND CRYPTO LIMERICKS   See this week's stock picks HERE Follow John C. Dvorak on Twitter Follow Andrew Horowitz on Twitter

Cerebrospinal fluid (CSF) is a clear liquid that acts like a cushion for your brain and spinal cord. It also helps wash away waste and brings nutrients to your brain. Normally, this fluid flows through tunnels in your brain and down your back.Think of it like a plumbing system in a house. If a pipe gets clogged or squeezed, the water has nowhere to go and starts to build up. When the flow of CSF is blocked, the fluid builds up inside your head. This creates extra pressure against your brain and the inside of your skull, which causes a painful headache.Common reasons for this "clog" include:The shape of the skull: Sometimes the back of the skull is too small, pushing part of the brain downward and blocking the fluid's path.A "kink" in the pipe: If the neck or spine is out of alignment, it can squeeze the space where the fluid flows.Injury: A bad bump or fall can sometimes cause swelling that slows down the flow.When the pressure is relieved and the fluid can flow freely again, the headaches usually go away. That is why chiropractic care should be an obvious choice for resolving headaches.Core Health Darienlink to schedulehttps://calendly.com/corehealth/headacheThis podcast welcomes your feedback here are several ways to reach out to me. If you have a topic you would like to hear about send me a message. I appreciate your listening. Dr. Brian Mc Kayhttps://twitter.com/DarienChiro/https://www.facebook.com/ChiropractorBrianMckayhttps://chiropractor-darien-dr-brian-mckay.business.sitehttps://podcasts.apple.com/us/podcast/not-just-chiropractor-for-stamford-darien-norwalk-new/id1503674397?uo=4Core Health Darien-Dr.Brian Mc Kay 551 Post RoadDarien CT 06820203-656-363641.0833695 -73.46652073GMP+87 Darien, Connecticuthttps://youtu.be/WpA__dDF0O041.0834196 -73.46423349999999https://darienchiropractor.comhttps://darienchiropractor.com/darien/darien-ct-understanding-pain/Find us on Social Mediahttps://chiropractor-darien-dr-brian-mckay.business.site https://www.youtube.com/channel/UCNHc0Hn85Iiet56oGUpX8rwhttps://docs.google.com/spreadsheets/d/1nJ9wlvg2Tne8257paDkkIBEyIz-oZZYy/edit#gid=517721981https://goo.gl/maps/js6hGWvcwHKBGCZ88https://www.youtube.com/my_videos?o=Uhttps://www.linkedin.com/in/darienchiropractorhttps://www.facebook.com/ChiropractorBrianMckayhttps://sites.google.com/view/corehealthdarien/https://sites.google.com/view/corehealthdarien/home

Cerebrospinal fluid surrounds the brain, brainstem and spinal cord, it fills spaces within them, is continually produced and drained away, but why? 

Cerebrospinal fluid shows brain-region-specific dynamics, a new high-resolution MRI approach reveals.

Your brain and spinal cord are floating in something called cerebrospinal fluid, or CSF, and when brain tumors develop they shed cells and cellular components into this fluid. A new test developed by director of neurosurgery Chetan Bettegowda at Johns … Cerebrospinal fluid can tell lots about brain tumors, Elizabeth Tracey reports Read More »

Tumor components and immune response indicators can be found in cerebrospinal fluid, or CSF, when someone has a brain tumor, in a new test developed by Chetan Bettagowda, director of neurosurgery at Johns Hopkins and one of the test's developers.  … Cerebrospinal fluid may hold the keys to brain cancer identification and treatment, Elizabeth Tracey reports Read More »

Fluid systems always connect to each other. Change the name and change sizes it doesn't matter. They all connect. See why this matters in healing  Blood. Lymph. Cerebrospinal fluid. Interstitial fluid. 

Discussing a question I received asking where the blood brain barrier is located. In addition, we go over information about the blood csf barrier. This is strictly for educational purposes. The information in this video is not meant as a substitute for professional medical advice.Here's a link to the previous video on the blood brain barrier.https://spotifycreators-web.app.link/e/BQceRCwlKRbPlease like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible.Resources:https://www.sciencedirect.com/topics/neuroscience/area-postrema#:~:text=The%20area%20postrema%20refers%20to,actions%20that%20lead%20to%20illness.https://qbi.uq.edu.au/brain/brain-anatomy/what-blood-brain-barrier#:~:text=The%20brain%20is%20precious%2C%20and,of%20the%20blood%E2%80%93brain%20barrier.https://www.cancer.gov/publications/dictionaries/cancer-terms/def/choroid-plexushttps://journals.lww.com/glaucomajournal/fulltext/2013/06001/production_and_circulation_of_cerebrospinal_fluid.5.aspxhttps://fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-020-00230-3https://my.clevelandclinic.org/health/articles/22266-meningeshttps://pmc.ncbi.nlm.nih.gov/articles/PMC2821375/https://www.frontiersin.org/journals/neuroanatomy/articles/10.3389/fnana.2021.665803/full#F1https://pmc.ncbi.nlm.nih.gov/articles/PMC1871727/https://pmc.ncbi.nlm.nih.gov/articles/PMC7768803/https://pmc.ncbi.nlm.nih.gov/articles/PMC4120694/Image resources:https://www.cancer.gov/publications/dictionaries/cancer-terms/def/choroid-plexushttps://med.libretexts.org/Bookshelves/Anatomy_and_Physiology/Anatomy_and_Physiology_%28Boundless%29/11%3A_Central_Nervous_System/11.3%3A_Protection_of_the_Brain/11.3C%3A_Ventricleshttps://www.hydroassoc.org/understanding-the-choroid-plexus-function-location-and-its-role-in-hydrocephalus/https://www.researchgate.net/figure/blood-cerebrospinal-fluid-CSF-barrier-The-choroid-plexus-has-fenestrated-capillaries_fig1_325373010https://neuroscientificallychallenged.com/glossary/fourth-ventriclehttps://www.researchgate.net/figure/Area-Postrema-is-Anatomical-Marker-for-the-Subregion-of-NTS-of-Primary-Hypothetical_fig1_259320952https://www.rit.edu/spotlights/blood-brain-barrierhttps://www.cell.com/heliyon/fulltext/S2405-8440%2824%2911593-9https://www.aginganddisease.org/EN/10.14336/AD.2022.0130-1http://epilepsygenetics.net/the-epilepsiome/slc2a1-this-is-what-you-need-to-know/https://www.mdpi.com/2072-6643/16/14/2363https://www.mdpi.com/2072-6643/11/11/2636https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2019.00282/fullhttps://teachmephysiology.com/immune-system/innate-immune-system/phagocytosis/https://oehha.ca.gov/chemicals/methylmercury-and-methylmercury-compoundshttps://www.mdpi.com/2073-4409/11/18/2823https://www.simplypsychology.org/brain-ventricles.htmlhttps://www.frontiersin.org/files/Articles/123479/fnins-09-00032-HTML/image_m/fnins-09-00032-g001.jpghttps://www.researchgate.net/figure/Cerebrospinal-fluid-flow-Cerebrospinal-fluid-is-mainly-produced-in-the-lateral_fig2_370857837https://www.physio-pedia.com/CSF_Cerebrospinal_Fluid

We are excited to host  Mauro Zappaterra on this episode of the Mangu.tv podcast. Mauro Zappaterra, MD, PhD, earned his degrees from Harvard Medical School and specialises in physical medicine and rehabilitation, focusing on human performance, awareness, and pain reduction. Pra ctising mindfulness since 1998, he has taught it to chronic pain patients since 2018. As Director of Multidisciplinary Care at Synovation Medical Group, he integrates new research on cerebrospinal fluid and pain management. Dr. Zappaterra has authored numerous scientific papers and books, including I Am, All One, All Love, and Close Your Eyes, What Do You See? co-written with his son, emphasising awareness and imagination. His alphabet book, A is for Awareness, and programs like Awakening Awareness reflect his dedication to mindfulness, healing, and expanding consciousness. Mauro shares the story of his upbringing, and early curiosity in human development and the power of the mind. He speaks about his studies in molecular biology and dissatisfaction with the format of his learning thus leading him down the holistic path and Craniosacral therapy which informed his PhD in Cerebrospinal fluid.  Giancarlo and Mauro discuss the mystical and scientific significance of cerebrospinal fluid as well as ways to tune into this fluid and space through breath and meditation.  Mauro shares his philosophy that by doing these practices, we understand who we truly are, and the connection with the totality of the universe.

At Holistic Integration, we are inspired daily by the success stories of our patients.  This week, we share with you three of our favorite stories from this year and also talk with Julie Kline of the Trinity Health Freedom Expo about their upcoming event.  In this episode, you'll find out:—The reason Dr. Prather "knows" a patient is improving based on objective lab tests and exams that prove they are getting better, usually even before they start to feel a change in their symptoms.—How Erin lost 70 pounds and also experienced a "night and day" improvement in her mental health through the Holistic Integration DTS Fat Loss Program. —What healthy fat loss looks like and the "critical" importance of diagnostics. —Why a Dentist who came to Holistic Integration called the CranioSacral Therapy he received to be "cathartic" and "freeing".—The conditions that benefit from CranioSacral Therapy, including:  Autism, Migraines, ADD/ADHD, football concussion syndrome.  And how the brain can "actually regenerate" when the Cerebrospinal fluid flow is moving correctly.—How Jayne, a retired doctor, was facing a leg amputation from a wound that would not heal...until she came to Holistic Integration.—Why Laser Acupuncture is effective for wound healing. —Plus, you'll find out how you can hear Dr. Robert Prather speak about "The Solution To Our Health Crisis" by attending the Trinity Health Freedom Expo on September 28th and 29th at the Plainfield, Indiana Embassy Suites Hotel and Conference Center.http://www.TheVoiceOfHealthRadio.com

Six persons have died from Cerebrospinal Meningitis in the Upper West Region. This has pushed the total death toll from the disease to ten this year.

This week, we are joined by Holistic Integration's own Meghan Walton and Dr. Clinton Dodge to talk about the benefits of CranioSacral Therapy.  In this episode, we talk about:—The conditions helped by CranioSacral Therapy, including:  Autism, Migraines, ADD/ADHD, Football Concussion trauma/CTE, pain, TMJ, sleep problems, hormonal imbalances, stomach issues, Vagal nerve issues, anxiety, depression, brain fog, and immune system support.—How the brain can actually change shape and can be damaged when the Cerebrospinal fluid is not moving correctly.  And how the brain can "actually regenerate" when the Cerebrospinal fluid flow is corrected.—Why the Cerebrospinal fluid is really important for "the healing of the nervous system” and protects the brain and spinal cord.  And how the Cerebrospinal fluid should flow through your body at a rate of six to twelve cycles a minute. —The history of CranioSacral Therapy and its roots in Osteopathy.  And how the development of CranioSacral Therapy helped to disprove the belief that the cranial bones are fused and no longer move after a certain age.—What the evaluation for CranioSacral Therapy and the treatment are like. —How the CranioSacral Therapy protocols are designed to put patients into a "healing brainwave state" for the brain that activates brainwaves that are also associated with sleep. —Why being in a "fight or flight" sympathetic nervous system mode will impede the flow of Cerebrospinal fluid and cause us to hold tension in our bodies that sometimes we aren't even aware of.—How patients say CranioSacral Therapy leaves them feeling "relaxed" and "renewed".  And how CranioSacral Therapy sometimes can even result in an emotional release. —The way CranioSacral Therapy and Chiropractic care work together to promote proper Cerebrospinal fluid flow.—The story of a Dentist who has experienced CranioSacral Therapy at Holistic Integration and found it to be "cathartic" and "freeing".http://www.TheVoiceOfHealthRadio.com

If you still believe that water is an inert substance and not a conscious living entity that gives us life, you probably missed last year's epic Living 4D conversation with Isabel Friend.For many of you who did listen to that podcast, you may have assumed Paul and Isabel covered everything you needed to know about water. Not so fast…Isabel returns to discuss water from a spiritual perspective for its ability to facilitate miracles and explains why Christianity is a water-based religion in this ethereal Living 4D conversation.Learn more about Isabel's work at her Water is Life website and on social media via Instagram and YouTube.For Living 4D listeners: Save 10 percent on any of Isabel's courses at her Water is Life Academy by using the promo code LIVING 4D at checkout. (Special offers from Living 4D guests are time-sensitive and at their discretion to redeem after 30 days.)TimestampsIsabel dropped out of college when she was 16 to become a monk. (3:40)Is Christianity a water-based religion? (10:38)Interpreting Christianity/the Bible from a water-based perspective. (18:18)Water myths. (39:27)Water: An infinite spectrum of expression. (52:10)The masculine and feminine qualities of water. (1:01:09)Water is a powerful badass that can do whatever she wants! (1:19:12)Is a rainbow real? (1:26:59)Water and energy fields. (1:45:24)Cerebrospinal fluid (CSF). (1:55:25)The personality of water. (2:19:22)Your bio water. (2:24:54)“It would be inhumane to treat a human being the way we treat water.” (2:46:20)ResourcesIndra's NetSecret Life of Symbols with Jordan Maxwell on GaiaThe Bible Code with Gregg Braden on YouTubeChanting Mantras With Deva Primal and Miten: A 21-Day Immersion in the Power of Sacred SoundLiquid DeathPaul's Living 4D conversations with John Stuart Reid and Sean O'LaoireFind more resources for this episode on our website.Thanks to our awesome sponsors:PaleovalleyBiOptimizers US and BiOptimizers UK PAUL10Organifi CHEK20CHEK Academy Open HouseWe may earn commissions from qualifying purchases using affiliate links.

Enjoy this episode? Please share it with at least ONE friend who you think needs to hear it! If you're a longtime listener of The Way Forward, you know how excited I get when I have guests on who talk about water and its relation to consciousness, health, and the nature of reality. In this episode, Alec is joined by Mauro Zappaterra, MD, PhD, to explore the relationship between our 4th-phase water, Cerebral Spinal Fluid (CSF), consciousness, the soul, Kundalini Yoga, Kundalini awakening, breathwork, and God. CSF is a fluid that surrounds and cushions the brain and spinal cord, playing a crucial role in their function. But, according to Dr. Zappaterra and his work, the purpose and importance of CSF is likely beyond anything we're told. Mauro Zappaterra obtained his MD and PhD from Harvard Medical School. He is board-certified in physical medicine and rehabilitation with a focus on optimizing human performance, increasing awareness and decreasing suffering. He has been practicing mindfulness since 1998, and teaching mindfulness to patients with chronic pain since 2018, and he is the Director of Multidisciplinary Care at Synovation Medical Group. He has led the Awakening Awareness Program and Inward Inquiry for the Emerging Sciences Foundation which can be found on YouTube.  He has published numerous scientific papers and medical book chapters on the cerebrospinal fluid, disability, and pain management. He has also published "I Am", "All One", and "All Love" which are three books exploring topics of awareness, primarily for kids, but really for people of all ages.  He has also published "Close Your Eyes, What Do You See?" with his son, which is a story about imagination and intention.  And he also published "A is for Awarness", a new alphabet book to expand your consciousness vocabulary.  He continues to create programs to help patients with chronic pain and investigate the cerebrospinal fluid and integrate new research to evolve the hypothesis of The Cerebrospinal Fluid and I Am. ————————— The Way Forward podcast is sponsored by: ORGANIC MUSCLE: Organic Muscle is revolutionizing sports nutrition by exclusively utilizing non-GMO ingredients from USDA Organic farms. Experience the fusion of organic purity and scientific excellence at https://organicmuscle.com, and unlock a 15% discount with code "Forward15" at checkout. & LIVING THE OFF-GRID DREAM: Turn your homesteading, retreat center, or off-grid dream into a reality with Living the Off-Grid Dream: Https://thewayfwrd.com/offgrid. Members of The Way Forward receive a free consultation with Jaymie. Become a member of The Way Forward here: https://thewayfwrd.com/membership-sign-up/ ————————— Join us for Confluence, April 5-8th in Bandera, TX. Confluence is a one-of-a-kind gathering on a regenerative ranch amongst health and freedom community that includes workshops, lectures, regeneratively-grown food, music, dancing, camping, glamping, bonfires, and more. Get tickets at ConfluenceEvent.com. Enter code ZECK10 at checkout for 10% off.  Check out last year's aftermovie: https://youtu.be/TqL2wVBKuo0?si=kC6hTJxZWdPn6HSv For more on The Way Forward, please visit: https://thewayfwrd.com Visit our online marketplace for discounts on a variety of the best holistic health brands and products: https://thewayfwrd.com/store/ For all of our links, visit: https://www.flowcode.com/page/thewayforward Support The Way Forward and Alec's work: https://thewayfwrd.com/donate/ FIND YOUR PEOPLE! Join The Way Forward to connect with like minded men and women near you, businesses near you, and more! The best part? You pay whatever you want!: https://thewayfwrd.com/membership-sign-up/ Do you run a freedom-oriented or holistic health-oriented business? Join our FREE business directory here:  https://thewayfwrd.com/directory-form/ You can watch The Way Forward Podcast on YouTube, Unite, Bitchute & Rumble Youtube: https://www.youtube.com/@TheWayFwrd Unite: https://unite.live/channels/the-way-forward/the-way-forward Bitchute: https://www.bitchute.com/channel/a3s3CiyELVd8/ Rumble: https://rumble.com/user/TheWayFwrd This material may not be published, broadcast, rewritten or redistributed in whole or in part without expressed written permission from The Way Forward, LLC. The purpose of this presentation is to convey information. It is not intended to diagnose, treat or cure a condition; nor is it to be considered medical or legal advice, opinion or recommendation. This information is presented in the spirit of service for all. Timestamps: The Bridge Between Spirit and Matter (0:00) Here I am but what else am I? (10:50) The constant cycle of creation and destruction (15:25) Divine Orchestration (20:33) Introduction to the research  (29:10) What happened during a craniosacral session (35:05) Cerebrospinal fluid and the realization (39:20) How breath affects the fluid (48:06) The bridge presentation (1:00:00) The fluid filled cavities of the brain (1:18:05) Breakdown on what cerebrospinal fluid is and where it resides (1:23:22) Where does cerebrospinal fluid come from (1:36:06) What is the role of CSF? (1:42:04) What causes the movement of CSF? (1:52:25) Our internal electrical generator (1:55:36)

MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021. Originally released: October 14, 2018 There is nothing mysterious about the chemistry of the cerebrospinal fluid. Cells. Protein. Glucose. But the interplay of these unique components can give you incredible insight into the state of the central nervous system. This week, we revisit a prior episode where Dr. Mike Rubenstein reviews his approach to interpreting CSF results. And then we have an update at the end regarding recent advances in CSF analysis. Produced by James E Siegler and Michael Rubenstein. Music by Steve Combs. Sound effects by Mike Koenig and Daniel Simion. Voiceover by Patrick Green (German). BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision-making. If you like what you hear, let us know, and rate the show! REFERENCES Deisenhammer F, Bartos A, Egg R, et al. Guidelines on routine cerebrospinal fluid analysis. Report from an EFNS task force. Eur J Neurol 2006;13(9):913-22. PMID 16930354Frederiks JA, Koehler PJ. The first lumbar puncture. J Hist Neurosci 1997;6(2):147-53. PMID 11619518Messacar K, Schreiner TL, Van Haren K, et al. Acute flaccid myelitis: a clinical review of US cases 2012-2015. Ann Neurol 2016;80(3):326-38. PMID 27422805Nagel MA, Cohrs RJ, Mahalingam R, et al. The varicella zoster virus vasculopathies: clinical, CSF, imaging, and virologic features. Neurology 2008;70(11):853-60. PMID 18332343Seehusen DA, Reeves MM, Fomin DA. Cerebrospinal fluid analysis. Am Fam Physician 2003;68(6):1103-8. PMID 14524396Shah KH, Edlow JA. Distinguishing traumatic lumbar puncture from true subarachnoid hemorrhage. J Emerg Med 2002;23(1):67-74. PMID 12217474  We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode's original release date.

Michelle and Alexander join TWiP to solve their case of the 36 Year Old Male with shortness of breath, stinging pain in the extremities, fatigue, abdominal cramps, and bowel irregularities, and discuss host cell invasion by Trypanosoma cruzi. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Guests: Michelle Naegeli and Alexander Grieb Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode cAMP-dependent invasion by Trypanosoma cruzi (PLoS NTDS) Letters read on TWiP 220 Become a patron of TWiP Case Study for TWiP 221 This is the case of a  man in his 50s, with no remarkable prior medical history, who received care at a hospital in northern California, USA, after experiencing a generalized seizure. Magnetic resonance imaging (MRI) demonstrated a solitary left temporal lobe T2 hyperintensity with gadolinium rim enhancement and surrounding edema. After receiving treatment with dexamethasone and levetiracetam, he was transferred to an academic medical center. Examination by neurology consultants noted disorientation, inattention, moderate aphasia (difficulty communicating), and mild right hemiparesis. Cerebrospinal fluid (CSF) testing revealed increased nucleated cells up to 80/UL (60% lymphocytes, 17% neutrophils, 23% monocytes), protein concentration 38 mg/dL, and glucose concentration 100 mg/dL.  They proceed to do a brain biopsy from the left temporal lobe lesion with cultures from the brain biopsy sample that did not grow bacteria, fungi, or mycobacteria. They performed metagenomic next-generation sequencing (mNGS) on a CSF sample and sent brain biopsy samples for universal broad-range PCR amplicon sequencing (uPCR) for bacteria, fungi, Mycobacterium tuberculosis, and nontuberculous mycobacteria. which is preliminarily reported as showing well-formed granulomata with acute inflammation. Rereview of neuropathology raised concern for certain round infectious forms that are about 50um in size with some surrounding clearing and a dark area within these forms. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

Bipolar Disorder has been listed as one of the leading disorders of the Global Burden of Diseases... Yet the amount of research and funding put towards it is abysmal. Laine and I share that during our clinical education, we were taught almost nothing about the experience of mania, diagnosing, or treating the disorders like Bipolar. This episode share's what we know so far (from the MANY articles Laine went through to try to make sense of it) and what's happening in the brain -- referencing studies from Harrison, Gettes, Tunbridge, Clark, Sahakian, and more. It also touches on what needs to be done to not only better support those who have experienced manic episodes or have been diagnosed, but what is required for the field of mental health to improve. The takeaways of this episode are some of our favorites -- you can hear it in Laine's voice at the end. Enjoy -- and as always, if you have any questions feel free to email us at info@brainblownpodcast.com. REFERENCES Dionisio et al. - "Cognitive flexibility impairment and reduced frontal cortex BDNF expression in the ouabain model of mania" Dzirasa et al. - "Impaired Limbic Gamma Oscillatory Synchrony during Anxiety-Related Behavior in a Genetic Mouse Model of Bipolar Mania" Ferrari et al. - "Depression and Mania Induce Pro-inflammatory Activation of Macrophages Following Application of Serum from Individuals with Bipolar Disorder" Schmidta et al. - "Cerebrospinal fluid hypocretin-1 (orexin A) levels in mania compared to unipolar depression and healthy controls" de Soussa et al. - "Lithium increases plasma brain-derived neurotrophic factor in acute bipolarmania: A preliminary 4-week study" Paul J. Harrison, John R. Geddes, and Elizabeth M. Tunbridge1 - "The Emerging Neurobiology of Bipolar Disorder" Luke Clark, Barbara J. Sahakian - "Cognitive neuroscience and brain imaging in bipolar disorder" G.S. Kirshenbaum, C. R. Burgess, N. De'ry, M. Fahnestock, J. H. Peever and J C Roder - "Attenuation of mania-like behavior in na+,k+-atpase a3 mutant mice by prospective therapies for bipolar disorder: melatonin and exercise" Emre Bora - "Neurocognitive features in clinical subgroups of bipolar disorder: A meta-analysis" Ryan W. Logan, Ph.D. and Colleen A. McClung, Ph.D. - "Animal Models of Bipolar Mania: The Past, Present and Future"

MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021. Originally released: July 18, 2017 This week's BrainWaves episode features a case of a middle-aged woman with progressive headaches and cranial neuropathies. The diagnosis of aseptic meningitis is made, and a differential diagnosis is illustrated. BrainWaves podcasts and online content are intended for medical education only and should not be used to guide medical decision-making in routine clinical practice. Any cases discussed in this episode are fictional and do not contain any patient health-identifying information. REFERENCES Chamberlain MC, Glantz M. Myelomatous meningitis. Cancer 2008;112(7):1562-7. PMID 18260094 Ginsberg L, Kidd D. Chronic and recurrent meningitis. Pract Neurol 2008;8(6):348-61. PMID 19015295 Hasbun R, Abrahams J, Jekel J, Quagliarello VJ. Computed tomography of the head before lumbar puncture in adults with suspected meningitis. N Engl J Med 2001;345(24):1727-33. PMID 11742046 Jolles S, Sewell WA, Leighton C. Drug-induced aseptic meningitis: diagnosis and management. Drug Saf 2000;22(3):215-26. PMID 10738845 Lee BE, Chawla R, Langley JM, et al. Paediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study of aseptic meningitis. BMC Infect Dis 2006;6:68. PMID 16603090 Logan SA, MacMahon E. Viral meningitis. BMJ 2008;336(7634):36-40. PMID 18174598 Negrini B, Kelleher KJ, Wald ER. Cerebrospinal fluid findings in aseptic versus bacterial meningitis. Pediatrics 2000;105(2):316-9. PMID 10654948 Nieuwenhuizen L, Biesma DH. Central nervous system myelomatosis: review of the literature. Eur J Haematol 2008;80(1):1-9. PMID 17961180 Nigrovic LE. Aseptic meningitis. Handb Clin Neurol 2013;112:1153-6. PMID 23622323 Sobol U, Stiff P. Neurologic aspects of plasma cell disorders. Handb Clin Neurol 2014;120:1083-99. PMID 24365373 van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med 2004;351(18):1849-59. PMID 15509818  We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode's original release date.

MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021. Originally released: September 17, 2020 You know the triad for normal pressure hydrocephalus (NPH). Wet, wobbly, and wacky. And you have probably heard of the Evan's index—the relative proportion of the lateral ventricles in reference to the inner table of the skull. But you might not have heard of high-convexity tight sulci. Now you have. Produced by James E Siegler. Music courtesy of Jason Shaw, Javolenus, and Lee Rosevere, under a Creative Commons License. The opening theme was composed by Jimothy Dalton. Sound effects by Mike Koenig and Daniel Simion. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision-making. Be sure to follow us on Twitter @BrainWavesaudio for the latest updates to the podcast. REFERENCES Allali G, Laidet M, Armand S, et al. A combined cognitive and gait quantification to identify normal pressure hydrocephalus from its mimics: The Geneva's protocol. Clin Neurol Neurosurg 2017;160:5-11. PMID 28605723Graff-Radford J, Gunter JL, Jones DT, et al. Cerebrospinal fluid dynamics disorders: Relationship to Alzheimer biomarkers and cognition. Neurology 2019;93(24):e2237-46. PMID 31719134Kitagaki H, Mori E, Ishii K, Yamaji S, Hirono N, Imamura T. CSF spaces in idiopathic normal pressure hydrocephalus: morphology and volumetry. AJNR Am J Neuroradiol 1998;19(7):1277-84. PMID 9726467Sasaki M, Honda S, Yuasa T, Iwamura A, Shibata E, Ohba H. Narrow CSF space at high convexity and high midline areas in idiopathic normal pressure hydrocephalus detected by axial and coronal MRI. Neuroradiology 2008;50(2):117-22. PMID 17992524We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode's original release date.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.31.526446v1?rss=1 Authors: Wardman, J. H., Jensen, M. N., Andreassen, S. N., Styrishave, B., Wilhjelm, J. E., Sinclair, A. J., MacAulay, N. J. Abstract: Background: Idiopathic intracranial hypertension (IIH) is a condition characterized by increased intracranial pressure (ICP), impaired vision, and headache. Most cases of IIH occur in obese women of childbearing age, though age, BMI, and female sex do not encompass all aspects of IIH pathophysiology. Systemic metabolic dysregulation has been identified in IIH with a profile of androgen excess. However, the mechanistic coupling between obesity/hormonal perturbations and cerebrospinal fluid dynamics remains unresolved. Methods: Female Wistar rats were either fed a high fat diet (HFD) or exposed to adjuvant testosterone treatment to recapitulate IIH causal drivers. Cerebrospinal fluid (CSF) and blood testosterone levels were determined with mass spectrometry, ICP and CSF dynamics with in vivo experimentation, and the choroid plexus function revealed with transcriptomics and ex vivo isotope-based flux assays. Results: HFD-fed rats presented with increased ICP, which was not accompanied by altered CSF dynamics or modified choroid plexus function. Chronic adjuvant testosterone treatment of lean rats caused elevated CSF secretion rate, in association with increased activity of the choroid plexus Na+,K+,2Cl- cotransporter, NKCC1. Conclusions: HFD-induced ICP elevation in experimental rats did not originate from an increased rate of CSF secretion. Such modulation of CSF dynamics only came about with adjuvant testosterone treatment, mimicking the androgen excess observed in female IIH patients. Obesity-induced androgen dysregulation may thus play a crucial role in the disease mechanism of IIH. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Dr Spyros Batzios describes a patient diagnosed with hyperphosphatasia with mental retardation syndrome 3 (also known as Mabry Syndrome) and reports on novel findings of CSF abnormalities and response to treatment with pyridoxine and folinic acid. Hyperphosphatasia with mental retardation syndrome 3: Cerebrospinal fluid abnormalities and correction with pyridoxine and Folinic acid Martina Messina, et al https://doi.org/10.1002/jmd2.12347

https://psychiatry.dev/wp-content/uploads/speaker/post-11306.mp3?cb=1672149492.mp3 Playback speed: 0.8x 1x 1.3x 1.6x 2x Download: Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment – PubMed Natalie Piehl et al. Cell. 2022. Cerebrospinal fluid (CSF)Full EntryCerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment – PubMed

What made the internet angry this week?Yumi Nu was on the cover of Sports Illustrated: Swimsuit Edition and Jordan Peterson isn't down with the thicc. Elon Musk's mom is also on the cover. They are doing studies on taking Cerebrospinal fluid from young people and putting them in old people to abate the aging process. Politics are boring. They're building a 789 million dollar museum and we are all in for it. Dale used to work at a military museum. Dale works with a guy who gets excited about random things. Girls on Tik Tok are saying the abortion ban will ruin hook up culture and conservatives are probably patting themselves on the back. Calling someone bald is sexual harassment. Elon Musk put buying twitter on hold. Crypto currency is still bullshit. Adidas made 43 different sports bras for breasts of all shapes and sizes and posted pictures of a bunch of tits.    Find us:Web outragefactory.comTwitter @OutrageFactPodInsta @outrage_factoryTik Tok @dalederuiterFacebook www.facebook.com/outragefactpodReddit r/OutragefactorypodEmail Outragefactpod@gmail.comCheck out our redbubble swag https://www.redbubble.com/shop/ap/49661850

Tune into our first guest episode featuring Colorado based comedian Brian Sullivan (Comedy Works, Loonees) who talks with Cameron and Thad about his professional fighting days! and as always laugh with us or don't at some new jokes!

Why clinical trials fail to validate efficacy of interventions predicted by observational studies of ‘risks' for dementia-Alzheimer syndrome?, Bi-directional Association of Cerebrospinal Fluid Immune Markers with Stage of Alzheimer's Disease Pathogenesis, and Cerebrospinal fluid protein markers suggest a pathway toward symptomatic resilience to AD pathology Prof John Breitner is Professor of Psychiatry at McGill University. He is also Director of the Centre for Studies on Prevention of Alzheimer's Disease at the Douglas Research Centre --- Send in a voice message: https://anchor.fm/scientificsense/message Support this podcast: https://anchor.fm/scientificsense/support

Cerebrospinal fluid is the clear fluid that surrounds the brain and spinal cord. It cushions the brain and spinal cord from injury, delivers nutrients and acts as a waste removal system for the brain. A cerebrospinal fluid leak occurs when fluid escapes through a small tear or hole in the outermost layer of tissue that surrounds the brain or the spinal cord. Leaks can occur in the skull or at any point along the spinal column. Because headache is a common symptom, patients are often misdiagnosed or mistreated for migraines. "About 85% of patients with a cerebrospinal fluid leak at the level of the spine will have an orthostatic headache — one that gets worse when they stand up and better when they lie down," says Dr. Jeremy Cutsforth-Gregory, a Mayo Clinic neurologist. Once properly diagnosed, a blood patch procedure is often an effective treatment for spinal cerebrospinal fluid leaks. The patient's own blood is injected into the spinal canal, and the blood clot that forms can stop the leak. In other patients, surgery or a novel procedure called paraspinal vein embolization may be more appropriate. On the Mayo Clinic Q&A podcast, Dr. Cutsforth-Gregory discusses diagnosing and treating spinal cerebrospinal fluid leaks.  

I read from cercaria to cerebrospinal.     The word of the episode is "cerebral".     dictionarypod@gmail.com https://www.facebook.com/thedictionarypod/ https://twitter.com/dictionarypod https://www.instagram.com/dictionarypod/ https://www.patreon.com/spejampar 917-727-5757

Dr. Wendy Neal, osteopath extraordinaire, talks us through the basic influences of cranial osteopathy: -mobility of bones in the head -mobility of sacrum -movement of CerebroSpinal fluid -movement of membranes around the brain and how gentle and subtle support to these movements can help support and calm conditions from seizures to headaches to pain, sleep and even constipation. 

You know the triad for normal pressure hydrocephalus (NPH). Wet, wobbly, and wacky. And you have probably heard of the Evan’s index—the relative proportion of the lateral ventricles in reference to the inner table of the skull. But you might not have heard of high-convexity tight sulci. Now you have. Produced by James E. Siegler. Music courtesy of Jason Shaw, Javolenus, and Lee Rosevere, under a Creative Commons License. The opening theme was composed by Jimothy Dalton. Sound effects by Mike Koenig and Daniel Simion. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision making. Be sure to follow us on Twitter @brainwavesaudio for the latest updates to the podcast. REFERENCES Kitagaki H, Mori E, Ishii K, Yamaji S, Hirono N and Imamura T. CSF spaces in idiopathic normal pressure hydrocephalus: morphology and volumetry. AJNR American journal of neuroradiology. 1998;19:1277-84. Sasaki M, Honda S, Yuasa T, Iwamura A, Shibata E and Ohba H. Narrow CSF space at high convexity and high midline areas in idiopathic normal pressure hydrocephalus detected by axial and coronal MRI. Neuroradiology. 2008;50:117-22. Allali G, Laidet M, Armand S, Momjian S, Marques B, Saj A and Assal F. A combined cognitive and gait quantification to identify normal pressure hydrocephalus from its mimics: The Geneva's protocol. Clinical neurology and neurosurgery. 2017;160:5-11. Graff-Radford J, Gunter JL, Jones DT, Przybelski SA, Schwarz CG, Huston J, 3rd, Lowe V, Elder BD, Machulda MM, Gunter NB, Petersen RC, Kantarci K, Vemuri P, Mielke MM, Knopman DS, Graff-Radford NR and Jack CR, Jr. Cerebrospinal fluid dynamics disorders: Relationship to Alzheimer biomarkers and cognition. Neurology. 2019;93:e2237-e2246.

In this week's episode of the Spine & Nerve podcast Dr. Nicolas Karvelas and Dr. Brian Joves discuss one the potential complications of procedures treating the spine- post dural puncture headaches(PDPHA). Listen in as the docs discuss the typical clinical presentation and the management of PDPHA.     PDPHA is defined as a headache that occurs within 5 days of intended or accidental dural compromise. It is caused by leakage of cerebrospinal fluid (CSF), and is usually accompanied by neck stiffness and/or subjective hearing changes. The symptoms usually remit spontaneously within 2 weeks or after autologous epidural blood patch.     The important aspects of the patient history / clinical presentation include but are not limited to: -history of dural puncture -postural component of headache (headache improves/resolves with lying flat, and worsens with sitting/standing) -location of headache is bi-frontal and/or occipital -onset of headache usually is within first 24-48 hours after dural puncture   Treatment of PDPHA depends on the severity / persistence of symptoms, and includes consideration of conservative management with bed rest, Acetaminophen, NSAIDs, caffeine; and the gold standard of treatment for severe or refractory PDPHA is autologous epidural blood patch.   Listen as the doctors discuss the definition, differential diagnosis, epidemiology, clinical presentation, pathophysiology (including normal CSF physiology), treatment (including the research behind autologous epidural blood patch), for post dural puncture headache.     This podcast is for information and educational purposes only, it is not meant to be medical or career advice. If anything discussed may pertain to you, please seek council with your healthcare provider. The views expressed are those of the individuals expressing them, they may not represent the views of Spine & Nerve. References: 1. Candido. Post-dural puncture headache:pathophysiology, prevention and treatment. Best Practice & Research Clinical Anaesthesiology. 2003. 2. Schievink et al. Spontaneous Spinal Cerebrospinal Fluid Leaks and Intracranial Hypotension. JAMA. 2006. 3. Neal JM. Update on postdural puncture headache. Techniques in Regional Anaesthesia and Pain Management 1998; 2: 202–210. 4. Vandam LD & Dripps RD. Long-term follow-up of patients who received 10,098 spinal anesthetics III. Syndrome of decreased intracranial pressure (headache and ocular and auditory difficulties). Journal of the American Medical Association 1956; 161: 586–591. 5. Battal et al. Cerebrospinal fluid flow imaging by using phase-contrast MR technique. Br J Radiol. 2011. 6. Abouleish E, Vega S, Blendinger I & Tio TO. Long-term follow-up of epidural blood patch. Anaesthesia and Analgesia 1975; 54: 459–463.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.15.153346v1?rss=1 Authors: Martinez-Gonzalez, K., Serrano-Cuevas, L., Almeida-Gutierrez, E., Flores-Chavez, S., Mejia-Arangure, J. M., Garcia-delaTorre, P. Abstract: INTRODUCTION: Alzheimer's disease (AD) correlates with the dysfunction of metabolic pathways that translates into neurological symptoms. An arginine deficiency, a precursor of nitric oxide (NO), has been reported for AD patients. We aimed to evaluate the effect of citrulline oral supplementation on cognitive decline in an AD murine model. METHODS: Three-month citrulline or water supplementation was blindly given to male and female wild type and 3xTg-AD mice trained and tested in the Morris Water Maze (MWM). Cerebrospinal fluid and brain tissue were collected. Ultra Performance Liquid Chromatography was used for arginine determinations while the Griess method was used for NO. RESULTS: Eight-month-old male 3xTg-AD mice supplemented with citrulline performed significantly better in the MWM task; arginine levels increased in cerebrospinal fluid although no changes were seen in brain tissue and only a tendency of increase of NO was observed. DISCUSSION: Citrulline oral administration is a viable treatment for memory improvement in the early stages of AD pointing to NO as a viable, efficient target for memory dysfunction in AD. Copy rights belong to original authors. Visit the link for more info

Learn about how our sun is different from similar stars; how deep sleep literally cleans your brain; and the psychology behind why some psychopaths are serial killers, while others are CEOs. Our sun is less active than other stars just like it, and scientists aren't sure why by Grant Currin Reinhold, T., Shapiro, A. I., Solanki, S. K., Montet, B. T., Krivova, N. A., Cameron, R. H., & Amazo-Gómez, E. M. (2020). The Sun is less active than other solar-like stars. Science, 368(6490), 518–521. https://doi.org/10.1126/science.aay3821  ‌Santos, Â. R. G., & Mathur, S. (2020). What future awaits the Sun? Science, 368(6490), 466–467. https://doi.org/10.1126/science.abb9208  Passant Rabie. (2020, April 30). The Sun’s midlife crisis could be making it stand out in the universe. Inverse; Inverse. https://www.inverse.com/science/why-is-the-sun-different  Space Weather | Ready.gov. (2020). Ready.Gov. https://www.ready.gov/space-weather  Deep sleep flushes toxins from your brain, and that seems to have genetic differences by Grant Currin Wright, B. L. C., Lai, J. T. F., & Sinclair, A. J. (2012). Cerebrospinal fluid and lumbar puncture: a practical review. Journal of Neurology, 259(8), 1530–1545. https://doi.org/10.1007/s00415-012-6413-x  ‌Harrison, S. (2019, October 31). Scientists Now Know How Sleep Cleans Toxins From the Brain. Wired; WIRED. https://www.wired.com/story/scientists-now-know-how-sleep-cleans-toxins-from-the-brain/  Fultz, N. E., Bonmassar, G., Setsompop, K., Stickgold, R. A., Rosen, B. R., Polimeni, J. R., & Lewis, L. D. (2019). Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep. Science, 366(6465), 628–631. https://doi.org/10.1126/science.aax5440  Why are some psychopaths serial killers and others CEOs? by Kelsey Donk Dodgson, L. (2018, May 20). The 10 professions with the most psychopaths - Business Insider. Business Insider; Business Insider. https://www.businessinsider.com/professions-with-the-most-psychopaths-2018-5  Not all psychopaths are violent; a new study may explain why some are “successful” instead. (2020). EurekAlert! https://www.eurekalert.org/pub_releases/2020-05/vcu-nap051220.php  Lasko, E., & Chester, D. (2020, April 24). What Makes a ‘Successful’ Psychopath? Longitudinal Trajectories of Offenders’ Antisocial Behavior and Impulse Control as a Function of Psychopathy. https://doi.org/10.31234/osf.io/rjg3q  Subscribe to Curiosity Daily to learn something new every day with Cody Gough and Ashley Hamer. You can also listen to our podcast as part of your Alexa Flash Briefing; Amazon smart speakers users, click/tap “enable” here: https://www.amazon.com/Curiosity-com-Curiosity-Daily-from/dp/B07CP17DJY

A UVA team is researching a slow-release gel that can be put on the head, like a shampoo, to enhance lymphatic function.

In our next installment of the JVS Editor’s choice series, Jacob discusses the JVS April Editor’s Choice articles with Senior Editor, Dr. Peter Lawrence.    Dr. Lawrence YouTube Video   STABLE II clinical trial on endovascular treatment of acute, complicated type B aortic dissection with a composite device design - CME and Editor’s Choice   Surgeon specialty significantly affects outcome of asymptomatic patients after carotid endarterectomy   Cerebrospinal fluid drainage complications during first stage and completion fenestrated-branched endovascular aortic repair   Outcomes of atherectomy for lower extremity ischemia in an office endovascular center If you enjoy our content, please contribute to Support Audible Bleeding!   Please provide us with feedback through our Listener Survey!  

Ted Talk Referenced: https://www.youtube.com/watch?v=FZ0q0JWRVn4 Thesis on Cerebrospinal Fluid Referenced: https://www.youtube.com/watch?v=55QythvgRRk In this episode of Turnpaugh Talks, Dr. Turnpaugh sits down with Dr. Erin Gattuso to learn a little bit more about how she got to where she is today. Dr. Gattuso comes from a family with a lot of unusual health conditions. She remembers going from doctor to doctor as a kid and seeing conventional medicine consistently fail to meet her family’s unique needs. This opened her eyes to alternative medicine. She studied neuroscience in undergrad. During this time, she heard about naturopathic medicine and, although hesitant at first, realized that was exactly what she wanted to do. Dr. Gattuso learned the gold standard of treatment, knowing which medications to give in a conventional setting, but also learned which herbs and dietary changes a patient may benefit from. She received a bottle of herbs early in her naturopathic studies. After years of trying to find a medication for something, she was able to use these herbs to treat it. This began her love for botanical medicine (herbs and plants). She uses this modality with her patients frequently. A lot of pharmaceutical medications are derived from plants and herbs. There is such a variety of ways plants and herbs can be used, even the same plant can be used for many different things. She shadowed Dr. Turnpaugh 8 years ago and had crossed paths with him at conferences multiple times since then. When THWC opened in Manheim, right down the street from her previous office, she saw it as a sign that this is where she was meant to be. She worked in a pediatricians office before coming to THWC, where she specialized in Cranial Sacral Therapy (CST). Dr. Gattuso explained that the skull expands and contracts in response to cerebrospinal fluid (the fluid within the nervous system) and in order for the nervous system to be healthy, you need proper flow of this fluid. Sensitive hands can feel this expansion and contraction rhythm in the skull. This is essentially the basis for CST. It is toning the nervous system in a very gentle manner. Dr. Gattuso specializes in CST on infants who are having trouble breastfeeding and in treating children who are neuroatypical. She has discovered over the years that a baby having a latching problem and a child growing up to be neuroatypical often go hand-in-hand. This is because the feeding and latching reflex and primitive reflexes all have to be in place for the nervous system to mature in a functional way. The cranial bones are all connected. Dr. Gattuso can work on the back of the head or the temporals and notice a difference in latching, despite not working in or around the mouth. When she puts a hold on a part of the body, such as the temporals, it sends a message to the nervous system to bring attention to that area, allowing the nervous system to correct itself. Many people don’t believe in Cranial Sacral Therapy, but there is so much evidence to show that there are parts of the nervous system that only respond to these light touches. We often use light touches ourselves, for example, when we bang our elbow on something, we gently rub it to help with the pain. Cerebrospinal fluid has a crucial impact on so many parts of the body. If you lose even just a few drops of it, you will be in terrible pain for days. Dr. Gattuso interned at a water fasting facility called True North, the most researched and well known fasting facility in America. She saw so many miracles in her time there, she watched people come off their medications, saw their mental clarity go through the roof, and saw their mood significantly improve. It really worked well for psychological conditions. One of the patients there was a medical doctor who had bone cancer, she knew in conventional therapy she would have at most 6 months to live. A year and a half after her diagnosis, it was her third stay at the clinic. Since she had started fasting, her bone cancer did not get any worse. Your body goes into a pure healing mode after a while of fasting. It searches for amino acids that are not essential to your body anymore and metabolizes them. This can include tumors or growths that your body cleans up. In a way, modern medicine is catching up with traditional medicine, medical doctors are trying fasting clinics and alternative approaches that our ancestors did thousands of years ago. At the THWC Spring Summit, Dr. Gattuso will be speaking on cell danger response. When cells are under too much stress, they go into a different state where they make enough energy to survive but not thrive. It is the root cause of many chronic conditions.

Jordan Ray is the Founder and Chief Executive Officer of Limitless Medical Logs. She created, manages and operates Limitless Medical Logs which provides doctor recommended medical logs for patients battling serious health conditions. The “Log” provides a way for people to accurately track their pain & symptoms daily. Patients and Physicians need the log's unlimited options for daily accurate tracking to enhance their treatment plan for their particular diagnosis or diagnoses. Jordan Ray was born in Davie, FL and grew up in Wellington, FL. She excelled as a student-athlete. She began playing softball at the age of 4 then began her competitive career in softball at age 8. She competed in travel from ages 8-17 being involved in the highest level of softball, traveling throughout the United States competing. At age 16 Jordan watched her mom battle and beat breast cancer, and at age 17 Jordan was diagnosed with Chiari Malformation: A condition in which brain tissue extends into the spinal canal, present at birth. This condition was discovered after she blacked out on the softball field during her junior year of high school due to her Cerebrospinal fluid being blocked to her brain. The diagnosis led to her having major brain surgery 3 months later. Based on her personal experiences, she saw the need for these “all in one” medical logs to benefit anyone who is battling an illness just like she is. Jordan wants to make a difference by helping people take control of their health and be an active participant in managing acute chronic conditions. Jordan and her story have been featured in The Palm Beach Post, The Sun Sentinel, The Town Crier, ESPN numerous magazine covers, speaking events, podcast interviews and she is also the Wellington Hometown Hero.

Estreando um novo segmento do nosso podcast, o TdC Lab! Rapha, João, Fred e Pedro discutem sobre Líquor: o que pedir, como interpretá-lo e quais são as pegadinhas que precisamos ficar atentos! Referências: 1- Hasbun R. Cerebrospinal fluid in central nervous system infections. In: Infections of the Central Nervous System, 4th edition, Scheld WM, Whitley RJ, Marra CM (Eds), Lippincott Williams, 2014. p.4. 2- Kimberly Johson Daniel Sexton. Cerebrospinal fluid: Physiology and utility of an examination in disease states UPTODATE 12/2019  3- Nilam J Soni et al. Ultrassound Guidance for Lumbar Puncture. Neurology Clinical Practice 2016 4- Kimberly Johnson, Daniel Sexton Lumbar Puncture: Technique, indications, contraindications, and complications in adults Uptodate 12/2019. 5- Basmaci, Romain, et al. Enteroviral meningitis does not exclude concurrent bacterial meningitis. Journal of clinical microbiology 49.9 (2011): 3442-3443. 6- Bailey, Elizabeth M., Philip Domenico, and Burke A. Cunha. Bacterial or viral meningitis? Measuring lactate in CSF can help you know quickly. Postgraduate medicine 88.5 (1990): 217-223. 7- Huy, Nguyen T., et al. Cerebrospinal fluid lactate concentration to distinguish bacterial from aseptic meningitis: a systemic review and meta-analysis. Critical care 14.6 (2010): R240. 8- Posner, Jerome B., and Fred Plum. Independence of blood and cerebrospinal fluid lactate. Archives of neurology 16.5 (1967): 492-496.

Jordan Ray is the Founder and Chief Executive Officer of Limitless Medical Logs. She created, manages and operates Limitless Medical Logs which provides doctor recommended medical logs for patients battling serious health conditions. The “Log” provides a way for people to accurately track their pain & symptoms daily. Patients and Physicians need the log’s unlimited options for daily accurate tracking to enhance their treatment plan for their particular diagnosis or diagnoses.  Jordan Ray was born in Davie, FL and grew up in Wellington, FL. She excelled as a student-athlete. She began playing softball at the age of 4 then began her competitive career in softball at age 8. She competed in travel from ages 8-17 being involved in the highest level of softball, traveling throughout the United States competing.   At age 16 Jordan watched her mom battle and beat breast cancer, and at age 17 Jordan was diagnosed with Chiari Malformation: A condition in which brain tissue extends into the spinal canal, present at birth. This condition was discovered after she blacked out on the softball field during her junior year of high school due to her Cerebrospinal fluid being blocked to her brain. The diagnosis led to her having major brain surgery 3 months later.    Based on her personal experiences, she saw the need for these “all in one” medical logs to benefit anyone who is battling an illness just like she is. Jordan wants to make a difference by helping people take control of their health and be an active participant in managing acute chronic conditions. Improving patient and physician communication.   Jordan and her story have been featured in The Palm Beach Post, The Sun Sentinel, The Town Crier, ESPN numerous magazine covers, speaking events, podcast interviews and she is also the Wellington Hometown Hero.    www.limitlessmedicallogs.com contact@limitlessmedicallogs.com Follow her and her company on Facebook, LinkedIn, Twitter and Instagram.    Facebook:  Jordan Ray  https://www.facebook.com/jordan.ray.9 Limitless Medical Logs https://www.facebook.com/limitlessmedicallogs/ LinkedIn:  Jordan Ray  https://www.linkedin.com/in/jordan-ray-394899126/ Limitless Medical Logs https://www.linkedin.com/company/limitless-medical-logs/?viewAsMember=true Twitter:  JordanRay25  https://twitter.com/JordanRay25 LMLbettterhealth https://twitter.com/LMLbetterhealth Instagram:  JordanRay25 Limitlessmedicallogs

Jordan Ray is the Founder and Chief Executive Officer of Limitless Medical Logs. She created, manages and operates Limitless Medical Logs which provides doctor recommended medical logs for patients battling serious health conditions. The “Log” provides a way for people to accurately track their pain & symptoms daily. Patients and Physicians need the log’s unlimited options for daily accurate tracking to enhance their treatment plan for their particular diagnosis or diagnoses.  Jordan Ray was born in Davie, FL and grew up in Wellington, FL. She excelled as a student-athlete. She began playing softball at the age of 4 then began her competitive career in softball at age 8. She competed in travel from ages 8-17 being involved in the highest level of softball, traveling throughout the United States competing.   At age 16 Jordan watched her mom battle and beat breast cancer, and at age 17 Jordan was diagnosed with Chiari Malformation: A condition in which brain tissue extends into the spinal canal, present at birth. This condition was discovered after she blacked out on the softball field during her junior year of high school due to her Cerebrospinal fluid being blocked to her brain. The diagnosis led to her having major brain surgery 3 months later.    Based on her personal experiences, she saw the need for these “all in one” medical logs to benefit anyone who is battling an illness just like she is. Jordan wants to make a difference by helping people take control of their health and be an active participant in managing acute chronic conditions. Improving patient and physician communication.   Jordan and her story have been featured in The Palm Beach Post, The Sun Sentinel, The Town Crier, ESPN numerous magazine covers, speaking events, podcast interviews and she is also the Wellington Hometown Hero.    www.limitlessmedicallogs.com contact@limitlessmedicallogs.com Follow her and her company on Facebook, LinkedIn, Twitter and Instagram.    Facebook:  Jordan Ray  https://www.facebook.com/jordan.ray.9 Limitless Medical Logs https://www.facebook.com/limitlessmedicallogs/ LinkedIn:  Jordan Ray  https://www.linkedin.com/in/jordan-ray-394899126/ Limitless Medical Logs https://www.linkedin.com/company/limitless-medical-logs/?viewAsMember=true Twitter:  JordanRay25  https://twitter.com/JordanRay25 LMLbettterhealth https://twitter.com/LMLbetterhealth Instagram:  JordanRay25 Limitlessmedicallogs

Amy joins the TWiV team to review evidence that enterovirus D68 is an etiologic agent of childhood paralysis, and her finding that the ability of the virus to infect cells of the nervous system is not a recently acquired property. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode EV-D68 antibodies in humans before 2014 outbreak (Emerg Inf Dis) Enterovirus antibodies in CSF of AFM patients (mBio) Serology implicates enteroviruses in AFM (Nat Med) EV-D68 neurotropism is not new (mBio) Letters read on TWiV 572 Timestamps by Jolene. Thanks! Weekly Science Picks Amy - Enterovirus biology and pathogenesis and Acute Flaccid Myelitis Association Rich - Tesla Dickson - Nikon Small World 2019 Photo Competition Kathy - Term limits in academic leadership #1 and #2 Vincent - Coywolf: New hybrid carnivore Listener Picks Anonymous - Spill the Beans vaccinated shirts Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Amy joins the TWiV team to review evidence that enterovirus D68 is an etiologic agent of childhood paralysis, and her finding that the ability of the virus to infect cells of the nervous system is not a recently acquired property. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode EV-D68 antibodies in humans before 2014 outbreak (Emerg Inf Dis) Enterovirus antibodies in CSF of AFM patients (mBio) Serology implicates enteroviruses in AFM (Nat Med) EV-D68 neurotropism is not new (mBio) Letters read on TWiV 572 Timestamps by Jolene. Thanks! Weekly Science Picks Amy - Enterovirus biology and pathogenesis and Acute Flaccid Myelitis Association Rich - Tesla Dickson - Nikon Small World 2019 Photo Competition Kathy - Term limits in academic leadership #1 and #2 Vincent - Coywolf: New hybrid carnivore Listener Picks Anonymous - Spill the Beans vaccinated shirts Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Is ketamine safe to use in TBI patients (or anyone with increased ICP)? The usual answer is “heck no!”, but where does this come from, and is it true? This week, Karl and I talk about the origin of this believe and the evidence behind the safety of ketamine in TBIs (and how it might actually improve outcome...) Literature Referenced: Original Lancet letter that started everything. Four cases of increased ICP after ketamine administration. Evans, J., Rosen, M., Weeks, R., Wise, C. (1971). Ketamine in neurosurgical procedures. Lancet (London, England) 1(7688), 40-1. https://www.ncbi.nlm.nih.gov/pubmed/4099342 Additional case reports at the time. Gardner, A., Olson, B., Lichticer, M. (1971). Cerebrospinal-fluid Pressure during Dissociative Anesthesia with Ketamine. Anesthesiology 35(2), 226-8. https://dx.doi.org/10.1097/00000542-197108000-00029 List, W., Crumrine, R., Cascorbi, H., Weiss, M. (1972). Increased Cerebrospinal Fluid Pressure after Ketamine Anesthesiology 36(1), 98-99. https://dx.doi.org/10.1097/00000542-197201000-00023 GANER, A., DANNEMILLER, F., DEAN, D. (1972). Intracranial Cerebrospinal Fluid Pressure in Man During Ketamine Anesthesia. Anesthesia & Analgesia 51(5), 741. https://dx.doi.org/10.1213/00000539-197209000-00019 SHAPIRO, H., WYTE, S., HARRIS, A. (1972). KETAMINE ANAESTHESIA IN PATIENTS WITH INTRACRANIAL PATHOLOGY BJA: British Journal of Anaesthesia 44(11), 1200-4. https://dx.doi.org/10.1093/bja/44.11.1200 Wyte, S., Shapiro, H., Turner, P., Harris, A. (1972). Ketamine-induced intracranial hypertension. Anesthesiology 36(2), 174-6. https://www.ncbi.nlm.nih.gov/pubmed/5059108 Gibbs, J. (1972). The effect of intravenous ketamine on cerebrospinal fluid pressure. British journal of anaesthesia 44(12), 1298-302. https://www.ncbi.nlm.nih.gov/pubmed/4650346 Animal study in pigs showing that ketamine reduces CBF. Björkman, S., Akeson, J., Nilsson, F., Messeter, K., Roth, B. (1992). Ketamine and midazolam decrease cerebral blood flow and consequently their own rate of transport to the brain: an application of mass balance pharmacokinetics with a changing regional blood flow. Journal of pharmacokinetics and biopharmaceutics 20(6), 637-52. https://www.ncbi.nlm.nih.gov/pubmed/1302766 First well designed human trial of ketamine administration in humans with intracranial pathology (tumors and SAH). Showed a decrease in ICP and CBF. Mayberg, T., Lam, A., Matta, B., Domino, K., Winn, H. (1995). Ketamine does not increase cerebral blood flow velocity or intracranial pressure during isoflurane/nitrous oxide anesthesia in patients undergoing craniotomy. Anesthesia and analgesia 81(1), 84-9. https://www.ncbi.nlm.nih.gov/pubmed/7598288 First human trial of ketamine in TBI patients. Albanèse, J., Arnaud, S., Rey, M., Thomachot, L., Alliez, B., Martin, C. (1997). Ketamine decreases intracranial pressure and electroencephalographic activity in traumatic brain injury patients during propofol sedation. Anesthesiology 87(6), 1328-34. https://www.ncbi.nlm.nih.gov/pubmed/9416717 Meta-analyses/reviews demonstrating the safety of ketamine in neuro patients. Zeiler, F., Teitelbaum, J., West, M., Gillman, L. (2014). The Ketamine Effect on ICP in Traumatic Brain Injury Neurocritical Care 21(1), 163-173. https://dx.doi.org/10.1007/s12028-013-9950-y Wang, X., Ding, X., Tong, Y., Zong, J., Zhao, X., Ren, H., Li, Q. (2014). Ketamine does not increase intracranial pressure compared with opioids: meta-analysis of randomized controlled trials Journal of Anesthesia 28(6), 821-827. https://dx.doi.org/10.1007/s00540-014-1845-3 Cohen, L., Athaide, V., Wickham, M., Doyle-Waters, M., Rose, N., Hohl, C. (2015). The Effect of Ketamine on Intracranial and Cerebral Perfusion Pressure and Health Outcomes: A Systematic Review Annals of Emergency Medicine 65(1), 43-51.e2. https://dx.doi.org/10.1016/j.annemergmed.2014.06.018

Sleep! We all know we need it, but why? And how does a good night’s rest contribute to our massive strength gains? In today’s episode we break down what sleep is, how sleep affects your brain, sleep and strength gains, and how to get a better night’s rest. Hopefully after listening to this episode, you get to bed early tonight!  We’ve got shirts!! https://femalestrengthacademy.com/shop/clothing/shirts/strongaf-apparel/ Eat for Strength and Eat for Strength - Cut courses are now LIVE: https://femalestrengthacademy.com/shop/courses/eat-for-strength/ Follow us on Instagram and tag us in your posts by using the hashtag #empoweredbyiron Find us on Patreon: www.patreon.com/empoweredbyiron Join our women’s only Facebook Group: https://m.facebook.com/groups/femalestrengthacademy Check out our sponsors: Fiercely Fueled Nutrition Coaching - Online nutrition coaching for strength and functional fitness athletes. Coached by our own Dr. Kristin Lander. Bama Brick Squad - Stacy offers various coaching services and packages: all geared towards helping you reach your goals. She works with athletes of all shapes and sizes. Support BBS and check out their merch!   Highlights: 2:00 - What is sleep? 6:32 - Two simple states of sleep: REM vs NREM 12:52 - Sleep and yo brain (Cerebrospinal fluid)  19:35 - Sleep and Learning & Memory 23: 55 - Sleep and yo body 28:55 - Sleep and being an athlete  34:31 - Sleep deprivation and exercise performance 36:57 - How to get better sleep

Niche Radio — Nova Chocolate is a sugar-free, gluten-free and vegan-friendly chocolate. However, in this episode, I discuss why the epigenetic consumption intake requires the liberal use of seaweeds. Marine vegetation can mitigate ocean acidification, study finds. The reason, however, eludes them: Polyunsaturated fatty acids (PUFAs) in marine vegetation have a lot of deuterium in them (Seafood/DHA does not) and this deuterium indirectly affects the salinity of seawater to affect the pH scale. Deuterium is capable of shifting pH because of its extra neutron compared to acids with H+. It turns out the oxygen isotope Oxygen-18 (O18) is linearly related to deuterium content in the water on Earth. The concentration of O18 in precipitation decreases with temperature. The coldest sites on Earth, in locations such as Antarctica and Greenland, have about 5 percent less O18 and deuterium than ocean water. When this water melts into seawater it dramatically affects the salinity of the sea. The same is true of Cerebrospinal fluid (CSF) in your brain. When you liberate O18 and deuterium in your body it has a radical effect on your salinity. We see this in neurosurgical conditions like Diabetes Inspidus, SIADH, and ANF. Does this relationship in nature scale to nature? It does. Many of the most important records of past climate variability from the tropical oceans are based on proxies linked to the stable isotopic composition of seawater. In particular, carbonate records of 18O derived from fossil corals and marine microfossils and shells of seafood are key indicators of past changes in ocean temperature and salinity. What are the implications of this? As we live in a 5G blue light world resulting in us to collect more deuterium and O18. As it accumulates in our tissues it will decrease our intrinsic salinity and we'll need more salt not less as we irradiate ourselves with nnEMF to maintain our bone mass.

Acá entre nos - A Spanglish Podcast: Episode 9 Our hosts Kelsey and Dawn-Marie gather in conversation with a mini little lecture that they have put together to share important information with their listeners on the brain and the importance of caring for this wonderful muscle.

Acá entre nos - A Spanglish Podcast: Episode 9 Our hosts Kelsey and Dawn-Marie gather in conversation with a mini little lecture that they have put together to share important information with their listeners on the brain and the importance of caring for this wonderful muscle.

There is nothing mysterious about the chemistry of the cerebrospinal fluid. Cells. Protein. Glucose. But the interplay of these unique components can give you incredible insight into the state of the central nervous system. This week, we revisit a prior episode where Dr. Mike Rubenstein reviews his approach to interpreting CSF results. And then we have an update at the end regarding recent advances in CSF analysis. Produced by James E. Siegler and Michael Rubenstein. Music by Steve Combs. Sound effects by Mike Koenig, Daniel Simion. Voiceover by Patrick Green (German). BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision making. If you like what you hear, let us know and rate the show! REFERENCES 1. Frederiks JA and Koehler PJ. The first lumbar puncture. J Hist Neurosci. 1997;6:147-53. 2. Seehusen DA, Reeves MM and Fomin DA. Cerebrospinal fluid analysis. Am Fam Physician. 2003;68:1103-8. 3. Shah KH and Edlow JA. Distinguishing traumatic lumbar puncture from true subarachnoid hemorrhage. J Emerg Med. 2002;23:67-74. 4. Deisenhammer F, Bartos A, Egg R, Gilhus NE, Giovannoni G, Rauer S, Sellebjerg F and Force ET. Guidelines on routine cerebrospinal fluid analysis. Report from an EFNS task force. European journal of neurology : the official journal of the European Federation of Neurological Societies. 2006;13:913-22. 5. Nagel MA, Cohrs RJ, Mahalingam R, Wellish MC, Forghani B, Schiller A, Safdieh JE, Kamenkovich E, Ostrow LW, Levy M, Greenberg B, Russman AN, Katzan I, Gardner CJ, Hausler M, Nau R, Saraya T, Wada H, Goto H, de Martino M, Ueno M, Brown WD, Terborg C and Gilden DH. The varicella zoster virus vasculopathies: clinical, CSF, imaging, and virologic features. Neurology. 2008;70:853-60. 6. Messacar K, Schreiner TL, Van Haren K, Yang M, Glaser CA, Tyler KL and Dominguez SR. Acute flaccid myelitis: A clinical review of US cases 2012-2015. Annals of neurology. 2016;80:326-38.

The Staying Young Show   Show Topic: Caring for One with Alzheimer's with Special Guest Alex Allred Co-Hosts:  Judy Gaman, Walter Gaman, Guest: Alex Allred  Segment 1 Being a caregiver can be hard, especially when caring for someone with Alzheimer's or Dementia. We have a very special guest coming up, Alex Allred author of Operation Caregivers. Share times when we have been the caregiver What do we see in patients that are also caregivers? Mental and Physical health issues What happens after a caregiver is relieved of their duties? Welcome Alexandra - Tell us why you wrote this book Doc Shock New term in the cardiovascular world came out in JAMA. It's called cardio vascular preconditioning. It's really just a fancy new word for exercise, but the important part is that exercise, even a single session has cardiovascular benefits. Each time the hart is put under the stress of exercise it experiences short episodes of ischemia, a term that means inadequate supply of blood to the heart. Repeated planned ischemic episodes, aka your daily or weekly exercise, prepares the heart to better handle a cardiac event where the heart may have a longer episode of blood flow interruption. Read Article Here Visit Our Website Follow Us On Facebook Follow Us On Twitter Download Our Show on iTunes Call us at 844-well-100  When we come back,  our special guest Alex Allred and more on her book Operation Careivers.     Segment 2 Intro  ANDERSON - Immortal minute – 2 min.   Your book deals with a lot of humor ... how does one find humor in Alzheimer's or dementia?   Why is this so important right now? Seems like we're suddenly hearing about dementia and Alzheimer's all the time now.   Caring for the caregiver: How to protect your own health and sanity while caring for a loved one.   Caregiver guilt: What it is, and how to give yourself grace?   Dementia and elder scams: How to protect your loved ones from getting ripped off?     Segment 3 Intro  Dementia Defender Teaser: 844-WELL-100   Today we're visiting with Alex Allred, author of Operation Caregivers -Operation Caregivers is VERY personal. Why share so many personal details of your parent lives? -What are the hard conversations you need to have with loved ones now, to better prepare for the future -Tips for speaking to a loved one with Alzheimer's/Dementia while retaining their dignity -Suddenly obtained power of attorney? Five things to do, and five things not to do -Dementia IS in your future. Here are three ways to prepare now for the inevitable ... (I know this is a bold statement and I do it on purpose because its true - you will either know someone, have a loved one or you yourself will be stricken but we don't have to be afraid of it)   Medical Mania Trivia – Guest Bryan  T or F Antibiotics are prescribed for viruses. (F) Is the brain attached to the top of the skull or does it simply float around? (suspended in Cerebrospinal fluid) The right side of the brain controls which side of the body? (the left) What is the purpose of the epiglottis and where is it found?(Back of the throat closes during swallowing to prevent food going down your windpipe) The duodenum, jejunum, and ileum are parts of what organ in the body? (Small intestine) Open discussion DEMENTIA DEFENDER THIS DEMENTIA DEFENDER IS BROUGHT TO YOU BY SMART NEW YOU AND DR. CHARLES POWELL. IF YOU HAVE SLEEP APNEA AND YOU'RE READY TO DITCH YOUR C-PAP MACHINE CALL  214-524-6333. Your last good ping-pong ball fell down into a narrow metal pipe imbedded in concrete one foot deep. How can you get it out undamaged, if all the tools you have are your tennis paddle, your shoe-laces, and your plastic water bottle, which does not fit into the pipe? Thank you for listening to the Staying Young Show! With all the mixed messages on health, you need information that you can use and that you can trust. Listen in as the experts discuss all topics health related. It's time to STAY YOUNG and stay healthy! Each week we tackle a topic and often with leading scientists, best-selling authors, and even your favorite celebrities! As a listener of our show, your input is important to us. Please take a moment to fill out this quick survey so we can serve you better - Survey For more information on The Staying Young Show, please visit our website, and subscribe to the show in iTunes, Stitcher, or your favorite podcast app. You can also reach out to our host, Judy Gaman, here for book purchasing, and speaking opportunities in your area!

It may look like water, but CSF is anything but. In this week's episode of BrainWaves, we discuss the contents of CSF and how to interpret them. BrainWaves podcasts and online content are intended for medical education only and should not be used to guide medical decision making in routine clinical practice. REFERENCES 1. Frederiks JA and Koehler PJ. The first lumbar puncture. J Hist Neurosci. 1997;6:147-53. 2. Seehusen DA, Reeves MM and Fomin DA. Cerebrospinal fluid analysis. Am Fam Physician. 2003;68:1103-8. 3. Shah KH and Edlow JA. Distinguishing traumatic lumbar puncture from true subarachnoid hemorrhage. J Emerg Med. 2002;23:67-74. 4. Deisenhammer F, Bartos A, Egg R, Gilhus NE, Giovannoni G, Rauer S, Sellebjerg F and Force ET. Guidelines on routine cerebrospinal fluid analysis. Report from an EFNS task force. European journal of neurology : the official journal of the European Federation of Neurological Societies. 2006;13:913-22. 5. Nagel MA, Cohrs RJ, Mahalingam R, Wellish MC, Forghani B, Schiller A, Safdieh JE, Kamenkovich E, Ostrow LW, Levy M, Greenberg B, Russman AN, Katzan I, Gardner CJ, Hausler M, Nau R, Saraya T, Wada H, Goto H, de Martino M, Ueno M, Brown WD, Terborg C and Gilden DH. The varicella zoster virus vasculopathies: clinical, CSF, imaging, and virologic features. Neurology. 2008;70:853-60. 6. Messacar K, Schreiner TL, Van Haren K, Yang M, Glaser CA, Tyler KL and Dominguez SR. Acute flaccid myelitis: A clinical review of US cases 2012-2015. Annals of neurology. 2016;80:326-38.

This week's BrainWaves episode features a case of a middle-aged woman with progressive headache and cranial neuropathies. The diagnosis of aseptic meningitis is made and a differential diagnosis is illustrated. BrainWaves podcasts and online content are intended for medical education only and should not be used to guide medical decision making in routine clinical practice. Any cases discussed in this episode are fictional and do not contain any patient health identifying information. REFERENCES 1. Nigrovic LE. Aseptic meningitis. Handbook of clinical neurology. 2013;112:1153-6. 2. van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma JB and Vermeulen M. Clinical features and prognostic factors in adults with bacterial meningitis. The New England journal of medicine. 2004;351:1849-59. 3. Hasbun R, Abrahams J, Jekel J and Quagliarello VJ. Computed tomography of the head before lumbar puncture in adults with suspected meningitis. The New England journal of medicine. 2001;345:1727-33. 4. Lee BE, Chawla R, Langley JM, Forgie SE, Al-Hosni M, Baerg K, Husain E, Strong J, Robinson JL, Allen U, Law BJ, Dobson S and Davies HD. Paediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study of aseptic meningitis. BMC Infect Dis. 2006;6:68. 5. Negrini B, Kelleher KJ and Wald ER. Cerebrospinal fluid findings in aseptic versus bacterial meningitis. Pediatrics. 2000;105:316-9. 6. Logan SA and MacMahon E. Viral meningitis. Bmj. 2008;336:36-40. 7. Ginsberg L and Kidd D. Chronic and recurrent meningitis. Pract Neurol. 2008;8:348-61. 8. Jolles S, Sewell WA and Leighton C. Drug-induced aseptic meningitis: diagnosis and management. Drug Saf. 2000;22:215-26. 9. Chamberlain MC and Glantz M. Myelomatous meningitis. Cancer. 2008;112:1562-7. 10. Nieuwenhuizen L and Biesma DH. Central nervous system myelomatosis: review of the literature. Eur J Haematol. 2008;80:1-9. 11. Sobol U and Stiff P. Neurologic aspects of plasma cell disorders. Handbook of clinical neurology. 2014;120:1083-99.

Charies Rogosky discusses Craniosacral Therapy with Don Ash, founder of the Craniosacral Therapy Alliance in New Hampshire. Don explains that there is a gentle movement of the head and spine based on the innate movement of the body. Based on this cranio rhythm the head opens and closes and the spine lengthens and shortens. Cerebrospinal fluid circulates up and down the spine and gives the central nervous system nutrition. Craniosacral Therapy, or CST, is just a light touch that works on the innate movement of the body. This light touch allows a CST therapist to evaluate the rhythm. By very gently stopping the rhythm the body self regulates, letting go of tensions it may be holding. Don says, “CST doesn’t cure anything. It helps your body work as good as it can”. This holistic approach creates an environment for your body to heal itself.

1) Cerebrospinal fluid AB42 predicting early onset Parkinson disease and 2) Topic of the month: Critical care neurology. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Matthew Barrett interviews Dr. Henrik Zetterberg about his paper on cerebrospinal fluid A?42 predicting early onset Parkinson disease. Dr. James Addington is reading our e-Pearl of the week about Kennedy disease. In the next part of the podcast Dr. Mike Brogan interviews Dr. Laurie Gutmann about critical illness in polyneuropathy and myopathy. The participants had nothing to disclose except Drs. Zetterberg, Addington and Gutmann.Dr. Zetterberg serves as Senior Editor of the Journal of Alzheimer's disease; serves as Associate Editor of Alzheimer and Dementia; receives research support from the Swedish Research Council and Swedish State Support for Clinical Research. Dr. Addington serves on the editorial team for the Neurology® Resident and Fellow Section. Dr. Gutmann receives royalties from Up-to-Date Online from the publication of Hypokalemic and Hyperkalemic Periodic Paralysis; receives research support from Alexion Pharmaceuticals, Inc. and the NIH.

In this podcast, Drs. Karl Golnik and Andrew Lee continue their Point-Counterpoint discussion on the topic Optic Nerve Sheath Fenestration vs Cerebrospinal Diversion Procedures

Alzheimer's disease is a complex progressive neurodegenerative disease leading to loss of memory and cognitive function, and pathologically characterized by amyloid plaques and tangles that are formed largely by fibular forms of beta-amyloid and hyper-phosphorylated tau proteins. During the past two decades, cumulative molecular and clinical studies have provided the basis for our understanding of the molecular characteristics and progressive pathologic features of these hallmarks.  

Tue, 1 Jan 2013 12:00:00 +0100 https://epub.ub.uni-muenchen.de/25829/1/Cerebrospinal_fluid_analyses.pdf Uhr, Manfred; Wick, Manfred; Petzold, Axel; Tumani, Hayrettin; Skagervik, Ina; Nagy, Karin

A first episode of central nervous system (CNS) demyelination may represent heterogeneous entities such as acute disseminated encephalomyelitis, clinically isolated syndrome, neuromyelitis optica (NMO), or multiple sclerosis. As new immune therapies become available, it is increasingly important to make an early diagnosis. In this podcast, Editor in Chief of Developmental Medicine & Child Neurology, Dr Peter Baxter, talks to Professor Russell Dale (Clinical School, The Children's Hospital at Westmead, Sydney) about the paper he co-authored in the September issue of the journal: 'Cerebrospinal fluid B-cell expansion in longitudinally extensive transverse myelitis associated with neuromyelitis optica immunoglobulin G' by Russell C Dale, Esther Tantsis, Vera Merheb, Fabienne Brilot. Read the paper:http://onlinelibrary.wiley.com/doi/10.1111/j.1469-8749.2011.03975.x/abstract

Cerebrospinal fluid is the clear fluid that surrounds the brain and spinal cord. It cushions the brain and spinal cord from injury, delivers nutrients and acts as a waste removal system for the brain. A cerebrospinal fluid leak occurs when fluid escapes through a small tear or hole in the outermost layer of tissue that surrounds the brain or the spinal cord. Leaks can occur in the skull or at any point along the spinal column. Because headache is a common symptom, patients are often misdiagnosed or mistreated for migraines. "About 85% of patients with a cerebrospinal fluid leak at the level of the spine will have an orthostatic headache — one that gets worse when they stand up and better when they lie down," says Dr. Jeremy Cutsforth-Gregory, a Mayo Clinic neurologist. Once properly diagnosed, a blood patch procedure is often an effective treatment for spinal cerebrospinal fluid leaks. The patient's own blood is injected into the spinal canal, and the blood clot that forms can stop the leak. In other patients, surgery or a novel procedure called paraspinal vein embolization may be more appropriate. On the Mayo Clinic Q&A podcast, Dr. Cutsforth-Gregory discusses diagnosing and treating spinal cerebrospinal fluid leaks.   Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy