POPULARITY
2 episodes with reaffirmation
4 episodes with reaffirmation
2 episodes with reaffirmation
2 episodes with reaffirmation
2 episodes with reaffirmation
2 episodes with reaffirmation
2 episodes with reaffirmation
25 episodes with reaffirmation
2 episodes with reaffirmation
Five Salvation Triggers… #1-Simeon's REGENERATION, v. 25a #2-Simeon's REVELATION, vv. 25b-26 #3-Simeon's REAFFIRMATION, vv. 27-28 #4-Simeon's REALIZATION, vv. 28-33
Five Salvation Triggers… #1-Simeon's REGENERATION, v. 25a #2-Simeon's REVELATION, vv. 25b-26 #3-Simeon's REAFFIRMATION, vv. 27-28 #4-Simeon's REALIZATION, vv. 28-33
Have you ever felt like your faith-driven efforts have fallen flat, leaving you exhausted and alone? This sermon explores Elijah's wilderness quest following Mount Carmel, revealing how God meets us in our darkest moments with gentle care and renewed purpose. Listen now and find hope in God's still, quiet voice.
In this episode of Yet Another Value Podcast, host Andrew Walker welcomes back Adam Patinkin of David Capital for his third appearance—this time for a much-requested update on British homebuilder and regeneration specialist Vistry (RY). Adam originally laid out a bold thesis in early 2024 that Vistry's transition to a pure-play partnerships business could mirror the NVR success story. But after a string of profit warnings and a collapsing share price, listeners wanted answers. Adam walks through what went wrong, why the company's current valuation doesn't match its fundamentals, and why David Capital doubled its position. The discussion probes management credibility, capital allocation, and how UK government policy is now aligning with Vistry's strategy.______________________________________________________________________[00:00:00] Intro and sponsor message for upcoming AI & finance webinar [00:00:40] Andrew welcomes Adam Patinkin for a follow-up discussion on Vistry [00:01:29] Context and disclaimer before discussing UK-listed stock Vistry [00:02:18] Adam gives a quick overview and update on Vistry's journey in 2024 [00:02:58] Explanation of David Capital doubling their position in Vistry [00:03:59] The original investment thesis in Vistry: value plus catalyst approach [00:04:51] Breakdown of Vistry's two segments: partnerships vs. housebuilding [00:06:58] Thesis: Transition to a pure-play partnerships business [00:08:34] Discussion on profit warnings and their impact on investor sentiment [00:10:13] Details of Vistry's missteps and housebuilding write-downs [00:12:29] Analysis of the market's reaction to one-time losses [00:15:29] Third warning due to delayed land sales and management's response [00:16:34] Clarification of misunderstandings around ongoing losses [00:17:57] Adam frames the four-part thesis and which parts still hold [00:19:09] Reaffirmation of medium-term targets for partnerships [00:20:54] Discussion on pace of housebuilding exit and management's actions [00:23:34] Ongoing share buybacks and potential for expansion [00:24:37] Breakdown of customer segments in the partnerships business [00:26:19] UK government's budget and policy impact on affordable housing [00:31:14] Overview of supportive labor government housing initiatives [00:35:05] Cash flow expectations from capital employed reduction [00:36:29] Valuation commentary and mispricing opportunities [00:37:54] Assessment of credibility and investment upside [00:41:51] Discussion on net debt figures and transparency [00:43:40] Capital structure comparisons with other builders [00:46:21] Considerations around lower buybacks vs. future flexibility [00:49:10] Why Vistry still represents compelling value despite concerns [00:52:08] Differentiating Vistry from UK housebuilder peers [00:55:05] Clarification of the NAV not falling due to deferred land sales [00:57:21] Framing margin of safety by cash flows rather than asset base [00:59:54] Summary of company positioning, tailwinds, and outlook Links:Daloopa Webinar: daloopa.com/yavwebinarDavid Capital: https://davidpartners.com/See our legal disclaimer here: https://www.yetanothervalueblog.com/p/legal-and-disclaimer
6TH SUNDAY AFTER THE EPIPHANY REV. KENDRA BALLIET ORGANIST JIM ROSS * Please Stand If Able Prelude - In Heavenly Love Abiding- Anna Waring Welcome & Announcements *Call to Worship Jesus declared, “Blessed are you who are poor, for yours is the kingdom of God.” May we learn to depend on God’s abundant provision instead of the world’s grasping for wealth as we worship today. Jesus declared, “Blessed are you who are hungry now, for you will be filled.” May we learn to follow Christ’s call to provide for the hungry as co-creators of God’s kingdom as we worship today. Jesus declared, “Blessed are you who weep now, for you will laugh.” May we learn to pay attention to those who suffer and mourn and to extend God’s comfort and hope to those who need it as we worship today. Jesus declared, “Blessed are you when people hate you and when they exclude you, revile you, and defame you on account of the Son of Man.” May our worship teach us to rejoice in that day and every day as we live out the good news in our families, neighborhoods, community, and world! * Opening Hymn – “O How I Love Jesus” #170 Opening Prayer Compassionate God, we recognize that our world is a broken place, hurt by poverty, famine, and disease. We admit that sometimes we make the world a broken place, tolerating prejudice, conflict, and self-interest. We confess that our hearts also suffer with anger, Resentment, and jealousy. Renew us in Your love, O God, and heal us with the comfort of Your abundant love. Awaken us to the role we can play in healing Your creation. Strengthen us through the power of the Holy Spirit to hear Your word and move forward in faith. Amen. Children’s Chat Scripture – 1 Corinthians 15:12-20, Luke 6:17-26 Pastor: The Word of God for the people of God. People: Thanks be to God Series: “Where You Are: Far Horizons” Message: “Embracing the Familiar” Tithes and Offering Offertory - Requiescant in Pace-Gordon Young *Doxology – Praise God from Whom All Blessings Flow #94 Prayers of the People - Joys and Concerns *Prayer Hymn – “Because He Lives” #364 Pastoral Prayer & Lord’s Prayer Reaffirmation of Our Baptism *Closing Hymn – “Through It All” # 507 Action Steps and Benediction Postlude - Fugue-J. S. Bach
6TH SUNDAY AFTER THE EPIPHANY REV. KENDRA BALLIET ORGANIST JIM ROSS * Please Stand If Able Prelude - In Heavenly Love Abiding- Anna Waring Welcome & Announcements *Call to Worship Jesus declared, “Blessed are you who are poor, for yours is the kingdom of God.” May we learn to depend on God’s abundant provision instead of the world’s grasping for wealth as we worship today. Jesus declared, “Blessed are you who are hungry now, for you will be filled.” May we learn to follow Christ’s call to provide for the hungry as co-creators of God’s kingdom as we worship today. Jesus declared, “Blessed are you who weep now, for you will laugh.” May we learn to pay attention to those who suffer and mourn and to extend God’s comfort and hope to those who need it as we worship today. Jesus declared, “Blessed are you when people hate you and when they exclude you, revile you, and defame you on account of the Son of Man.” May our worship teach us to rejoice in that day and every day as we live out the good news in our families, neighborhoods, community, and world! * Opening Hymn – “O How I Love Jesus” #170 Opening Prayer Compassionate God, we recognize that our world is a broken place, hurt by poverty, famine, and disease. We admit that sometimes we make the world a broken place, tolerating prejudice, conflict, and self-interest. We confess that our hearts also suffer with anger, Resentment, and jealousy. Renew us in Your love, O God, and heal us with the comfort of Your abundant love. Awaken us to the role we can play in healing Your creation. Strengthen us through the power of the Holy Spirit to hear Your word and move forward in faith. Amen. Children’s Chat Scripture – 1 Corinthians 15:12-20, Luke 6:17-26 Pastor: The Word of God for the people of God. People: Thanks be to God Series: “Where You Are: Far Horizons” Message: “Embracing the Familiar” Tithes and Offering Offertory - Requiescant in Pace-Gordon Young *Doxology – Praise God from Whom All Blessings Flow #94 Prayers of the People - Joys and Concerns *Prayer Hymn – “Because He Lives” #364 Pastoral Prayer & Lord’s Prayer Reaffirmation of Our Baptism *Closing Hymn – “Through It All” # 507 Action Steps and Benediction Postlude - Fugue-J. S. Bach
6TH SUNDAY AFTER THE EPIPHANY REV. KENDRA BALLIET ORGANIST JIM ROSS * Please Stand If Able Prelude - In Heavenly Love Abiding- Anna Waring Welcome & Announcements *Call to Worship Jesus declared, “Blessed are you who are poor, for yours is the kingdom of God.” May we learn to depend on God’s abundant provision instead of the world’s grasping for wealth as we worship today. Jesus declared, “Blessed are you who are hungry now, for you will be filled.” May we learn to follow Christ’s call to provide for the hungry as co-creators of God’s kingdom as we worship today. Jesus declared, “Blessed are you who weep now, for you will laugh.” May we learn to pay attention to those who suffer and mourn and to extend God’s comfort and hope to those who need it as we worship today. Jesus declared, “Blessed are you when people hate you and when they exclude you, revile you, and defame you on account of the Son of Man.” May our worship teach us to rejoice in that day and every day as we live out the good news in our families, neighborhoods, community, and world! * Opening Hymn – “O How I Love Jesus” #170 Opening Prayer Compassionate God, we recognize that our world is a broken place, hurt by poverty, famine, and disease. We admit that sometimes we make the world a broken place, tolerating prejudice, conflict, and self-interest. We confess that our hearts also suffer with anger, Resentment, and jealousy. Renew us in Your love, O God, and heal us with the comfort of Your abundant love. Awaken us to the role we can play in healing Your creation. Strengthen us through the power of the Holy Spirit to hear Your word and move forward in faith. Amen. Children’s Chat Scripture – 1 Corinthians 15:12-20, Luke 6:17-26 Pastor: The Word of God for the people of God. People: Thanks be to God Series: “Where You Are: Far Horizons” Message: “Embracing the Familiar” Tithes and Offering Offertory - Requiescant in Pace-Gordon Young *Doxology – Praise God from Whom All Blessings Flow #94 Prayers of the People - Joys and Concerns *Prayer Hymn – “Because He Lives” #364 Pastoral Prayer & Lord’s Prayer Reaffirmation of Our Baptism *Closing Hymn – “Through It All” # 507 Action Steps and Benediction Postlude - Fugue-J. S. Bach
6TH SUNDAY AFTER THE EPIPHANY REV. KENDRA BALLIET ORGANIST JIM ROSS * Please Stand If Able Prelude - In Heavenly Love Abiding- Anna Waring Welcome & Announcements *Call to Worship Jesus declared, “Blessed are you who are poor, for yours is the kingdom of God.” May we learn to depend on God’s abundant provision instead of the world’s grasping for wealth as we worship today. Jesus declared, “Blessed are you who are hungry now, for you will be filled.” May we learn to follow Christ’s call to provide for the hungry as co-creators of God’s kingdom as we worship today. Jesus declared, “Blessed are you who weep now, for you will laugh.” May we learn to pay attention to those who suffer and mourn and to extend God’s comfort and hope to those who need it as we worship today. Jesus declared, “Blessed are you when people hate you and when they exclude you, revile you, and defame you on account of the Son of Man.” May our worship teach us to rejoice in that day and every day as we live out the good news in our families, neighborhoods, community, and world! * Opening Hymn – “O How I Love Jesus” #170 Opening Prayer Compassionate God, we recognize that our world is a broken place, hurt by poverty, famine, and disease. We admit that sometimes we make the world a broken place, tolerating prejudice, conflict, and self-interest. We confess that our hearts also suffer with anger, Resentment, and jealousy. Renew us in Your love, O God, and heal us with the comfort of Your abundant love. Awaken us to the role we can play in healing Your creation. Strengthen us through the power of the Holy Spirit to hear Your word and move forward in faith. Amen. Children’s Chat Scripture – 1 Corinthians 15:12-20, Luke 6:17-26 Pastor: The Word of God for the people of God. People: Thanks be to God Series: “Where You Are: Far Horizons” Message: “Embracing the Familiar” Tithes and Offering Offertory - Requiescant in Pace-Gordon Young *Doxology – Praise God from Whom All Blessings Flow #94 Prayers of the People - Joys and Concerns *Prayer Hymn – “Because He Lives” #364 Pastoral Prayer & Lord’s Prayer Reaffirmation of Our Baptism *Closing Hymn – “Through It All” # 507 Action Steps and Benediction Postlude - Fugue-J. S. Bach
6TH SUNDAY AFTER THE EPIPHANY REV. KENDRA BALLIET ORGANIST JIM ROSS * Please Stand If Able Prelude - In Heavenly Love Abiding- Anna Waring Welcome & Announcements *Call to Worship Jesus declared, “Blessed are you who are poor, for yours is the kingdom of God.” May we learn to depend on God’s abundant provision instead of the world’s grasping for wealth as we worship today. Jesus declared, “Blessed are you who are hungry now, for you will be filled.” May we learn to follow Christ’s call to provide for the hungry as co-creators of God’s kingdom as we worship today. Jesus declared, “Blessed are you who weep now, for you will laugh.” May we learn to pay attention to those who suffer and mourn and to extend God’s comfort and hope to those who need it as we worship today. Jesus declared, “Blessed are you when people hate you and when they exclude you, revile you, and defame you on account of the Son of Man.” May our worship teach us to rejoice in that day and every day as we live out the good news in our families, neighborhoods, community, and world! * Opening Hymn – “O How I Love Jesus” #170 Opening Prayer Compassionate God, we recognize that our world is a broken place, hurt by poverty, famine, and disease. We admit that sometimes we make the world a broken place, tolerating prejudice, conflict, and self-interest. We confess that our hearts also suffer with anger, Resentment, and jealousy. Renew us in Your love, O God, and heal us with the comfort of Your abundant love. Awaken us to the role we can play in healing Your creation. Strengthen us through the power of the Holy Spirit to hear Your word and move forward in faith. Amen. Children’s Chat Scripture – 1 Corinthians 15:12-20, Luke 6:17-26 Pastor: The Word of God for the people of God. People: Thanks be to God Series: “Where You Are: Far Horizons” Message: “Embracing the Familiar” Tithes and Offering Offertory - Requiescant in Pace-Gordon Young *Doxology – Praise God from Whom All Blessings Flow #94 Prayers of the People - Joys and Concerns *Prayer Hymn – “Because He Lives” #364 Pastoral Prayer & Lord’s Prayer Reaffirmation of Our Baptism *Closing Hymn – “Through It All” # 507 Action Steps and Benediction Postlude - Fugue-J. S. Bach
6TH SUNDAY AFTER THE EPIPHANY REV. KENDRA BALLIET ORGANIST JIM ROSS * Please Stand If Able Prelude - In Heavenly Love Abiding- Anna Waring Welcome & Announcements *Call to Worship Jesus declared, “Blessed are you who are poor, for yours is the kingdom of God.” May we learn to depend on God’s abundant provision instead of the world’s grasping for wealth as we worship today. Jesus declared, “Blessed are you who are hungry now, for you will be filled.” May we learn to follow Christ’s call to provide for the hungry as co-creators of God’s kingdom as we worship today. Jesus declared, “Blessed are you who weep now, for you will laugh.” May we learn to pay attention to those who suffer and mourn and to extend God’s comfort and hope to those who need it as we worship today. Jesus declared, “Blessed are you when people hate you and when they exclude you, revile you, and defame you on account of the Son of Man.” May our worship teach us to rejoice in that day and every day as we live out the good news in our families, neighborhoods, community, and world! * Opening Hymn – “O How I Love Jesus” #170 Opening Prayer Compassionate God, we recognize that our world is a broken place, hurt by poverty, famine, and disease. We admit that sometimes we make the world a broken place, tolerating prejudice, conflict, and self-interest. We confess that our hearts also suffer with anger, Resentment, and jealousy. Renew us in Your love, O God, and heal us with the comfort of Your abundant love. Awaken us to the role we can play in healing Your creation. Strengthen us through the power of the Holy Spirit to hear Your word and move forward in faith. Amen. Children’s Chat Scripture – 1 Corinthians 15:12-20, Luke 6:17-26 Pastor: The Word of God for the people of God. People: Thanks be to God Series: “Where You Are: Far Horizons” Message: “Embracing the Familiar” Tithes and Offering Offertory - Requiescant in Pace-Gordon Young *Doxology – Praise God from Whom All Blessings Flow #94 Prayers of the People - Joys and Concerns *Prayer Hymn – “Because He Lives” #364 Pastoral Prayer & Lord’s Prayer Reaffirmation of Our Baptism *Closing Hymn – “Through It All” # 507 Action Steps and Benediction Postlude - Fugue-J. S. Bach
1. Tibetans Mourn the Passing of Former Kalon Tripa Gyalo Thondup 2. His Holiness the Dalai Lama Attends Long-life Prayer Offering at Tashi Lhunpo Monastery 3. Sikyong Penpa Tsering Commences Official Visit to Bylakuppe Tibetan Settlement 4. Former Tibetan Political Prisoner Namkyi Testifies at Geneva Summit 2025 5. Tibetan-Chinese Alliance Conference Urges Australian Government to Pressure PRC in Bilateral and Multilateral Talks 6. Australia launches Tibetan Youth Leadership and Advocacy Training 7. Tibetans and Japanese Observe the 112th Anniversary of Reaffirmation of Tibetan Independence Day 8. Tibetan Parliamentary Delegation Concludes Visit to Tibetan community in Belgium and France
The Fifth Sunday after EpiphanyHoly Communion with Confirmation & Reaffirmation
This weekend brought a rare Snow Day to Newnan, so in an abundance of caution Newnan First United Methodist canceled in-person services. Revs. Andrew Chappell and Connor Bell gathered to record a devotional that was live streamed, which you can listen to here! The following was also sent out in an email: In the life of the church, today is known as Baptism of the Lord Sunday. This is a day every year that we celebrate the baptism of Jesus in the Jordan River. The story according to Luke is as follows: As the people were filled with expectation and all were questioning in their hearts concerning John [the Baptist], whether he might be the Messiah, John answered all of them by saying, “I baptize you with water, but one who is more powerful than I is coming; I am not worthy to untie the strap of his sandals. He will baptize you with the Holy Spirit and fire. His winnowing fork is in his hand to clear his threshing floor and to gather the wheat into his granary, but the chaff he will burn with unquenchable fire.” Now when all the people were baptized and when Jesus also had been baptized and was praying, the heaven was opened, and the Holy Spirit descended upon him in bodily form like a dove. And a voice came from heaven, “You are my Son, the Beloved; with you I am well pleased.” For Luke and the other gospel writers, this moment is the launching point of Jesus' ministry. And from this point on, baptism becomes a key sacrament in the Christian story. In our tradition, baptism is both an individual and a communal act. The individual being baptized (or sponsor) takes vows to uphold after his or her baptism (or upon confirmation). And the community then makes its covenant once again to uphold the vows they took at their baptism. Thus, baptism is a covenant between the individual, God, and the church community. Baptism is also a celebration of the community of faith. Whenever a baptism occurs, it reminds us of our shared history and our ongoing journey together. Baptism strengthens our bond as Christians. Lastly, baptism is a reminder of Christ's presence. It signifies the ongoing presence of Christ within the individual and within the community. Christ is not gone. He is with us and he is in us! In the United Methodist Church, we have a ritual to let everyone once again hear the promises made and the blessings conferred, “A Service of Reaffirmation,” (a reaffirmation of the covenant, we call it). It's a way of saying again what we said or was said in our name at our baptism. I invite you to read through the vows of the Reaffirmation of Baptism liturgy below and spend a moment in reflection. Think about how it is you are living out the covenant vows of your baptism today. Baptismal Vows and Reaffirmation. Do you renounce the spiritual forces of wickedness, reject the evil powers of this world, and repent of your sin? I do. Do you accept the freedom and power God gives you to resist evil, injustice, and oppression in whatever forms they present themselves? I do. Do you confess Jesus Christ as your Savior, put your whole trust in his grace, and promise to serve him as your Lord, in union with the Church which Christ has opened to people of all ages, nations, and races? I do. According to the grace given to you, will you remain faithful members of Christ's holy Church and serve as Christ's representatives in the world? I will. Let us rejoice in the faithfulness of our covenant God. We give thanks for all that God has already given us. As members of the body of Christ and in this congregation of The United Methodist Church, we will faithfully participate in the ministries of the Church by our prayers, our presence, our gifts, our service and our witness that in everything God may be glorified through Jesus Christ. Friends, on this Baptism of the Lord Sunday, remember your baptism and be thankful! “Today is a grand celebration of the community of faith. It is a day of worship of the one who went into the water for us, with us, and promised to be present among us always.” -quote from UMC Discipleship
Why was Jesus baptized and why is that significant?
In this episode, Dr. Valentin Fuster discusses groundbreaking research on SGLT2 inhibitors and their impact on heart failure, highlighting the validation of mechanistic proteomic signatures from a major clinical trial. The study reveals how empagliflozin influences over 2,000 proteins, promoting autophagy, enhancing mitochondrial health, and normalizing kidney function, offering new insights into therapeutic strategies for heart failure management.
Sermon Outline: "Nothing is Too Hard for the Lord" Genesis 17-18 1. God's Promise to Abraham and Sarah Genesis 17:17-19 Abraham laughed at God's promise of having a son at his old age. Thomas Watson's Commentary: Abraham's laughter reflects human weakness in understanding God's promises, yet reveals God's power to overcome human limitations. God reaffirms the covenant, emphasizing His sovereignty. Key Verse: “Is anything too hard for the Lord?” (Genesis 18:14) 2. Human Tendency to Bargain with God Genesis 17:18 Abraham attempts to bargain with God over Ishmael, reflecting human fragility. Psalm 50:21: "You thought I was one like yourself. But now I rebuke you." We must rest in God's mercy, recognizing no bargains are needed—Christ has secured salvation on the cross. 3. God's Reaffirmation of His Covenant Genesis 18:1-8 The Lord appears in the form of three men (a veiled reference to the Trinity). Abraham gives his best to God, preparing a meal. Application: Offer God our best, not our leftovers. 4. Sarah's Doubt and God's Response Genesis 18:9-12 Sarah laughs at the idea of bearing a child, questioning God's ability. Genesis 18:14: "Is anything too hard for the Lord?" Cross References: Matthew 19:26: "With God, all things are possible." Romans 4:21: "Fully persuaded that God had power to do what He had promised." Application: We must trust in God's promises even when they seem impossible. 5. The Call to Be Salt and Light Genesis 18:13-14 The Lord rebukes Sarah's doubt, reminding her (and us) that nothing is beyond His power. Application: We are called to trust God's plan and be His witnesses, advancing His kingdom no matter where we are. 6. Confession and Repentance Genesis 18:15 Sarah denies her laughter, but God knows the truth. Application: We cannot hide anything from God. Repentance is essential, and we must surrender our doubts to Him. Reflection Questions: Where in your life are you tempted to doubt God's promises, like Sarah? How does Genesis 18:14 challenge that doubt? Have there been times when you tried to "bargain" with God, as Abraham did? How does the cross remind us that no deal needs to be struck? In what ways can you offer your best to God, just as Abraham did with his meal? What are some areas where you might be giving Him your leftovers? How can you practically be "salt and light" in your community, trusting that God will work through you to bring His kingdom?
Sermon Outline: "Nothing is Too Hard for the Lord" Genesis 17-18 1. God's Promise to Abraham and Sarah Genesis 17:17-19 Abraham laughed at God's promise of having a son at his old age. Thomas Watson's Commentary: Abraham's laughter reflects human weakness in understanding God's promises, yet reveals God's power to overcome human limitations. God reaffirms the covenant, emphasizing His sovereignty. Key Verse: “Is anything too hard for the Lord?” (Genesis 18:14) 2. Human Tendency to Bargain with God Genesis 17:18 Abraham attempts to bargain with God over Ishmael, reflecting human fragility. Psalm 50:21: "You thought I was one like yourself. But now I rebuke you." We must rest in God's mercy, recognizing no bargains are needed—Christ has secured salvation on the cross. 3. God's Reaffirmation of His Covenant Genesis 18:1-8 The Lord appears in the form of three men (a veiled reference to the Trinity). Abraham gives his best to God, preparing a meal. Application: Offer God our best, not our leftovers. 4. Sarah's Doubt and God's Response Genesis 18:9-12 Sarah laughs at the idea of bearing a child, questioning God's ability. Genesis 18:14: "Is anything too hard for the Lord?" Cross References: Matthew 19:26: "With God, all things are possible." Romans 4:21: "Fully persuaded that God had power to do what He had promised." Application: We must trust in God's promises even when they seem impossible. 5. The Call to Be Salt and Light Genesis 18:13-14 The Lord rebukes Sarah's doubt, reminding her (and us) that nothing is beyond His power. Application: We are called to trust God's plan and be His witnesses, advancing His kingdom no matter where we are. 6. Confession and Repentance Genesis 18:15 Sarah denies her laughter, but God knows the truth. Application: We cannot hide anything from God. Repentance is essential, and we must surrender our doubts to Him. Reflection Questions: Where in your life are you tempted to doubt God's promises, like Sarah? How does Genesis 18:14 challenge that doubt? Have there been times when you tried to "bargain" with God, as Abraham did? How does the cross remind us that no deal needs to be struck? In what ways can you offer your best to God, just as Abraham did with his meal? What are some areas where you might be giving Him your leftovers? How can you practically be "salt and light" in your community, trusting that God will work through you to bring His kingdom?
Sermon Title: "God's Faithfulness Through Our Failures: Lessons from Abram's Journey" I. Introduction: Learning from Abram's Journey A. Brief Recap of Genesis 12: Abram's failure to trust God during the famine and his decision to go to Egypt. Highlight the consequences of relying on his own understanding rather than God's guidance. Emphasize how these actions led to personal compromise and family tension. B. Transition to Genesis 13: Despite Abram's failures, God remains faithful. God's grace is not thwarted by human error; He continues His plan of redemption. II. Choosing Faith over Fear (Genesis 13:1-4) A. Returning to the Place of Worship: After leaving Egypt, Abram returns to Bethel, where he had previously built an altar. Discuss the significance of “returning” and how it symbolizes repentance and realignment with God's will. B. Worship as a Response to God's Deliverance: God delivers Abram and Sarai from Egypt, and Abram's response is worship. The proper response to God's mercy and grace is worship and gratitude, not guilt or shame. III. The Test of Generosity and Trust (Genesis 13:5-13) A. Conflict Between Abram and Lot: The land cannot support both Abram's and Lot's herds, leading to tension. Rather than escalate the conflict, Abram offers Lot the first choice of land. B. Lot's Worldly Decision: Lot chooses the fertile plains of Jordan, which are near the sinful city of Sodom. Discuss how Lot's decision reflects worldly desires and how it foreshadows future trouble. C. Abram's Faith in God's Provision: Abram's willingness to let Lot choose first shows his growing faith in God's promises. Abram trusts that God will provide, no matter the outcome. IV. God's Reaffirmation of His Promise (Genesis 13:14-18) A. God's Assurance After Separation from Lot: God reaffirms His promise to Abram after he parts ways with Lot. God invites Abram to “look in every direction” and promises him descendants as numerous as the dust of the earth. B. Building Another Altar: Abram's response to God's reaffirmation is worship once again—he builds another altar. Emphasize the pattern of worship in Abram's life and how it reflects a heart aligned with God. V. Application: Trusting in God's Faithfulness Despite Our Failures A. Return to God After Failure: Like Abram, we often fail in trusting God, but He is always ready to welcome us back when we repent. Returning to where we last encountered God's presence and favor is crucial. B. Choose Faith Over Selfish Gain: Lot's choice represents a focus on temporary, worldly gain, whereas Abram's choice reflects eternal values. Encourage the congregation to choose God's path, even if it seems less favorable by worldly standards. C. Rejoice in God's Unchanging Faithfulness: God's faithfulness to Abram, despite his missteps, should remind us of God's unwavering commitment to His promises. Reference Philippians 1:6 and C.H. Spurgeon's quote on God's continuous work in our lives. VI. Conclusion: God's Faithfulness and Our Response A. God's Goodness in the Midst of Our Failures: Even when we fail, God's goodness remains. He does not abandon His children but works all things for His glory. B. Call to Action: Repent of areas where we have tried to “help” God by taking matters into our own hands. Trust in His timing and His promises, just as Abram learned to do. C. Encouragement and Hope: God's plans are not thwarted by our failures. Walk confidently, knowing that He who began a good work in you will see it through to completion.
Sermon Title: "God's Faithfulness Through Our Failures: Lessons from Abram's Journey" I. Introduction: Learning from Abram's Journey A. Brief Recap of Genesis 12: Abram's failure to trust God during the famine and his decision to go to Egypt. Highlight the consequences of relying on his own understanding rather than God's guidance. Emphasize how these actions led to personal compromise and family tension. B. Transition to Genesis 13: Despite Abram's failures, God remains faithful. God's grace is not thwarted by human error; He continues His plan of redemption. II. Choosing Faith over Fear (Genesis 13:1-4) A. Returning to the Place of Worship: After leaving Egypt, Abram returns to Bethel, where he had previously built an altar. Discuss the significance of “returning” and how it symbolizes repentance and realignment with God's will. B. Worship as a Response to God's Deliverance: God delivers Abram and Sarai from Egypt, and Abram's response is worship. The proper response to God's mercy and grace is worship and gratitude, not guilt or shame. III. The Test of Generosity and Trust (Genesis 13:5-13) A. Conflict Between Abram and Lot: The land cannot support both Abram's and Lot's herds, leading to tension. Rather than escalate the conflict, Abram offers Lot the first choice of land. B. Lot's Worldly Decision: Lot chooses the fertile plains of Jordan, which are near the sinful city of Sodom. Discuss how Lot's decision reflects worldly desires and how it foreshadows future trouble. C. Abram's Faith in God's Provision: Abram's willingness to let Lot choose first shows his growing faith in God's promises. Abram trusts that God will provide, no matter the outcome. IV. God's Reaffirmation of His Promise (Genesis 13:14-18) A. God's Assurance After Separation from Lot: God reaffirms His promise to Abram after he parts ways with Lot. God invites Abram to “look in every direction” and promises him descendants as numerous as the dust of the earth. B. Building Another Altar: Abram's response to God's reaffirmation is worship once again—he builds another altar. Emphasize the pattern of worship in Abram's life and how it reflects a heart aligned with God. V. Application: Trusting in God's Faithfulness Despite Our Failures A. Return to God After Failure: Like Abram, we often fail in trusting God, but He is always ready to welcome us back when we repent. Returning to where we last encountered God's presence and favor is crucial. B. Choose Faith Over Selfish Gain: Lot's choice represents a focus on temporary, worldly gain, whereas Abram's choice reflects eternal values. Encourage the congregation to choose God's path, even if it seems less favorable by worldly standards. C. Rejoice in God's Unchanging Faithfulness: God's faithfulness to Abram, despite his missteps, should remind us of God's unwavering commitment to His promises. Reference Philippians 1:6 and C.H. Spurgeon's quote on God's continuous work in our lives. VI. Conclusion: God's Faithfulness and Our Response A. God's Goodness in the Midst of Our Failures: Even when we fail, God's goodness remains. He does not abandon His children but works all things for His glory. B. Call to Action: Repent of areas where we have tried to “help” God by taking matters into our own hands. Trust in His timing and His promises, just as Abram learned to do. C. Encouragement and Hope: God's plans are not thwarted by our failures. Walk confidently, knowing that He who began a good work in you will see it through to completion.
In the weekend message introducing the book of Jonah, Rick stated there are two common views to interpreting the story of Jonah: historical narrative or primarily parable. In this episode Rick and Svea discuss a question posed to them: Does Jesus' reference to Jonah in Matthew 12, when foretelling his own death and resurrection, support a particular interpretation of Jonah?Topics discussed in this episode:00:00 Intro01:04 Our unity isn't based on everyone agreeing on everything. Our unity is based on inclusion in Christ. It's okay to have different understandings on a variety of topics and still maintain unity.03:12 Many of us only thought of Jonah as a miraculous, historical account. Learning people view this book as anything other than history can be destabilizing and feel like a slippery slope to less allegiance toward the Bible.08:51 The astute question: Jesus referencing Jonah.11:40 Four options for interpreting Jesus' reference to Jonah.17:17 Reaffirmation of the authority and inerrancy of Scripture when multiple viewpoints of interpreting passages like Jonah are present.
This week we wrap up the 10 commandments and Exodus chapter 20. Dave recaps Exodus 19-20 and the amazing scene before Mount Sinai. Join as we conclude the decalogue (10 words) of God. Outline: 52:21 - Exodus chapter 19 and 20 recap 06:38 - Exo 20.18-21 - Thunder, lightning and trumpets (Exo 19.16-29, Pro 9.10) 11:38 - Exo 20.22-23 - Reaffirmation of 1st & 2nd Commandments: Link to GotQuestions.org article on why idol worship was such a challenge for ancient Israel: https://www.gotquestions.org/Baal-and-Asherah.html 13:30 - Exo 20.24 - Make an Altar. Gen 8.20, 4.3-5, Exo chapter 25-40 18:10 - Why are the 10 commandments repeated in Deut 5? 20:28 - What is the purpose of the 10 commandments? Exo 19.3-8, Matthew ch23 Support Iron Sheep Ministries: https://Ironsheep.org/donate Listen to the podcast: https://anchor.fm/ironsheep Contact Dave & the ISM team: info@ironsheep.org Be notified of each new teaching, join the email list: http://eepurl.com/g-2zAD Books used or referenced: Dave reads from an NIV (New International Version) of the Bible. Courson, Jon. Jon Courson's Application Commentary Old Testament Vol. 1. Nashville, TN: Thomas Nelson, 2005. https://www.christianbook.com/coursons-application-commentary-genesis-revelation-volumes/jon-courson/9780310118312/pd/0118312?event=ESRCG Enns, Peter. The NIV Application Commentary, Exodus. Grand Rapids, MI: Zondervan, 2000. https://www.christianbook.com/exodus-niv-application-commentary/peter-enns/9780310206071/pd/0206073?event=ESRCG --- Support this podcast: https://podcasters.spotify.com/pod/show/ironsheep/support
This devotional emphasizes the themes of grace, redemption, and divine purpose, using the biblical story of Peter as a central example. The speaker begins by encouraging listeners to verify the biblical references for themselves and underscores the importance of God's grace, as illustrated in Julia H. Johnson's hymn 'Grace Greater Than Our Sin.' The narrative then transitions to Peter's journey from denying Christ to becoming a pivotal figure at Pentecost, where he leads 3,000 people to Christ. The speaker reflects on Peter's initial return to fishing after Jesus' crucifixion, a metaphor for returning to old ways, and how Jesus refocused Peter on his mission to 'fish for men,' leading to his transformative role at Pentecost. The devotional concludes with a prayer for guidance and a call to share the message of hope and purpose, echoing Peter's experience of redemption and calling. 00:00 Opening Remarks and the Importance of Devotion 00:46 Exploring the Marvelous Grace of God 01:43 Peter's Transformation and the Power of Baptism 03:21 The Miraculous Catch and Jesus's Appearance 05:15 Peter's Reaffirmation and Jesus's Charge 06:39 Reflecting on Peter's Journey and Preaching at Pentecost 08:31 Understanding Preaching Methods and Peter's Impact 10:09 Closing Prayer and Encouragement to Share the Message --- Send in a voice message: https://podcasters.spotify.com/pod/show/gnbc/message
Sunday, April 14, 2024 Bishop Robert Wright is with us for a service of Confirmation, Reception, and Reaffirmation. The Rt. Rev. Robert Wright is the 10th bishop of the Episcopal Diocese of Atlanta. The Diocese of Atlanta is comprised of 120 worshipping communities throughout middle and north Georgia.
On October 22, 2020, 34 countries signed the Geneva Consensus Declaration on Promoting Women's Health and Strengthening the Family. Though it lacked any legal obligations, the statement was intended to express that it was indeed possible to advance the health and wellbeing of women and protect the lives of the preborn at the same time. The original list of countries included the United States. In fact, then Secretary of State Mike Pompeo helped to architect the project. Eight days after becoming president, Joe Biden removed the United States from the list of signatories in line with the foreign policy of the last two democratic presidents, who used access to U.S. aid to advance abortion and LGBTQ ideology around the world. On Wednesday in Washington D.C., seven U.S. Congressional leaders and ambassadors from Guatemala and Hungary hosted 36 original signatories to the Geneva Consensus Declaration, to reaffirm the commitment to protect “both the rights of women and unborn children.” Senator James Lankford from Oklahoma put it bluntly: “When families are strong, nations are strong. When families are weak, nations are weak.”
Pamala McCoy, author, International Speaker, and Founder of B5 Reaffirmation Box. Stay Connected pamalamccoy.com Subscribe to Beepodcast Newsletter for updates, special events and be a part of this vibrant community of change-makers. Don't miss out! Tune in to the "Black Entrepreneur Experience" podcast, and be sure to subscribe, share, and listen to our episodes as we navigate the path to entrepreneurial greatness together. Your support helps us amplify the voices and stories that need to be heard. Together, we can create a thriving ecosystem of Black entrepreneurship. Subscribe to our Newsletter https://www.drfrancesrichards.com/ for updates, special events and be a part of this vibrant community of change-makers. Don't miss out! Tune in to the "Black Entrepreneur Experience" podcast, and be sure to subscribe, share, and listen to our episodes as we navigate the path to entrepreneurial greatness together. Your support helps us amplify the voices and stories that need to be heard. Together, we can create a thriving ecosystem of Black entrepreneurship.
Sponsor: Click here to learn more about Medi-Share, the most trusted name in health care sharing.Top headlines for Monday, October 2, 2023In today's episode, we focus on a monumental legal battle, with the US Supreme Court agreeing to hear arguments on whether Texas and Florida can prevent social media platforms from censoring conservative viewpoints. Next, we turn our attention to the political arena, as we unpack five key facts you need to know about Florida Governor Ron DeSantis, spotlighted in a recent presidential debate at the prestigious Ronald Reagan Presidential Library in California. Switching gears, we'll explore the ramifications of a new reaffiliation policy from a United Methodist Church body, put in place for congregations that had previously left over ideological clashes on homosexuality. Finally, we examine an empowering gathering of students from over a dozen North Texas schools at the Prestonwood Baptist Church for what's being heralded as the nation's “premiere” Christian worldview conference.Subscribe to this Podcast Apple Podcasts Spotify Google Podcasts Overcast Follow Us on Social Media @ChristianPost on Twitter Christian Post on Facebook @ChristianPostIntl on Instagram Subscribe on YouTube Get the Edifi App Download for iPhone Download for Android Subscribe to Our Newsletter Subscribe to the Freedom Post, delivered every Monday and Thursday Click here to get the top headlines delivered to your inbox every morning! Links to the News Supreme Court agrees to hear social media censorship cases | Politics News Foster agencies may soon require families to affirm LGBT kids | Politics News 5 things to know about Ron DeSantis | Politics News Over 90% of voters say 'Gender Queer' is 'inappropriate': poll | U.S. News Dianne Feinstein, pioneering US senator, dies at 90 | Politics News TCG unveils initiative combating biblical illiteracy, heresy | Church & Ministries News United Methodist conference creates 'reaffiliation' policy | Church & Ministries News Biblical Worldview Conference looks at evidence for resurrection | Church & Ministries News Julie Chen Moonves details her radical conversion Christianity | Living News
Exploring Jeremiah 33: A Message of Restoration and HopeThe Book of Jeremiah, found in the Old Testament of the Bible, is replete with prophetic messages, warnings, and promises of both judgment and restoration. Chapter 33 of Jeremiah stands out as a poignant proclamation of God's unwavering faithfulness, His promise of restoration, and the ultimate fulfillment of His covenant with His people.Context and Background Jeremiah was a prophet called by God to deliver messages primarily to the people of Judah during a tumultuous time in their history.The nation was facing the consequences of their disobedience and unfaithfulness to God's laws. Jerusalem was under threat from the Babylonian empire, and the people were living through a period of uncertainty and fear.A Message of Hope in DesperationIn Jeremiah 33, the Lord speaks to the prophet while he is still confined in the court of the guard. The setting itself symbolizes the dire circumstances facing the people.In the midst of this adversity, God delivers a message that resonates with hope and promise.The chapter begins with God's affirmation of His power and might. He declares, "Call to me and I will answer you and tell you great and unsearchable things you do not know" (Jeremiah 33:3, NIV). This verse encapsulates the essence of seeking God in times of trouble and His willingness to reveal profound truths to those who earnestly seek Him.Promise of Restoration.One of the central themes of Jeremiah 33 is restoration. God reassures His people that despite the impending destruction and exile, He will not abandon them. In verses 6-9, God promises to bring healing and restoration to the land, cities, and people of Judah. The once desolate and ravaged land will once again flourish, and the people will experience a renewal of joy and thanksgiving.The Branch of RighteousnessJeremiah 33:15 introduces a powerful Messianic prophecy, referring to the coming of the "Branch of righteousness." This term is often associated with the future arrival of the Messiah, Jesus Christ. This prophecy highlights the eternal nature of God's covenant and His promise to establish a righteous and just ruler from the lineage of David. Reaffirmation of the CovenantThroughout Jeremiah 33, God emphasizes His unbreakable covenant with David and the Levites. He assures that just as the day and night are constant, so too is His commitment to His people. Despite their shortcomings, God promises to fulfill His covenant and restore them to a place of honor and significance.Conclusion Jeremiah 33 serves as a remarkable chapter in the book, encapsulating the essence of God's unending faithfulness and His desire for reconciliation with His people. It speaks of restoration in the midst of devastation, hope in the face of despair, and the promise of a righteous ruler who would bring salvation to the world. This chapter continues to resonate with believers today, reminding us of the enduring nature of God's promises and His redemptive plan for humanity. Just as God reassured the people of Judah through Jeremiah, He invites us to call upon Him, to seek His wisdom, and to trust in His unwavering love and grace.SendMe Radio is now an online streaming internet radio station, packed with all the messages on the podcast. Listen to awesome Interviews, thousands of Gospel Music, and discover new businesses and their inspiring stories. Also if you would like a radio commercial for your Church, social or business event contact us via email digitalink@sendmeradio.com Google Assistant Google Action is available on Google Home: https://assistant.google.com/services/a/uid/000000aec764f20f?hl=enAlexa skill is available on Amazon: https://www.amazon.com/dp/B0BLN6LHMSendMe Radio Apple Store App for IOS https://apps.apple.com/us/app/sendme-radio/id6444263130SendMe Radio Google Play App for Android https://play.google.com/store/apps/details?id=com.icreo.sendmeradio
Sermon Notes - Genesis 13:1-18 - Walking By Faith Through ConflictMain Point: Walking by faith (not by sight) enables us to overcome conflict as we trust God every step of the way.-The Reason for the Conflict (1-7)-The Resolution of the Conflict (8-13)-The Reaffirmation of the Promise (14-18)
Key Takeaways and Tax Planning Points:Enacted as part of the Inflation Reduction Act (IRA), corporations are now subject to a 15% minimum tax on book income of $1 billion or more. The IRA also provided $80 billion of funding for IRS – with $46 billion earmarked specifically for enforcement. Enacted as part of the 2023 Omnibus Appropriations legislation, the SECURE Act of 2022 contains a host of retirement provisions such as changes to 401k, IRS, Roth, and other plan rules. While the current Administration's “Green Book” on tax policy has not yet been released, a few tax proposals were discussed during the February 2023 State of the Union Address: Establishment of a new increase from a 1% excise tax on stock buybacks (enacted August 2022) to 4% excise tax Establishment of a new “billionaires” tax – households with net wealth exceeding $100 million would pay a minimum rate of 20% on an expanded computation of income, which would include unrealized capital gains. Reaffirmation by President Biden that the government would not raise taxes on anyone earning under $400,000/year. As Congress is split politically, it remains difficult for meaningful new tax legislation to make it through both houses and clear the President's desk in the near term.Resources: Navigating the Intersection of Tax & ESG Is Your Company Effectively Managing Tax Risk?How to Benefit from Total Tax Transparency
Our guest today is Nataliia Drozd, Marketing and UA Lead at Fabulous - an app focused on building healthy habits. In today's conversation, Nataliia shares her first hand experience in operating as a marketer in the midst of the war in Ukraine. While this episode isn't about tips-and-tactics on mobile marketing, we hope that it offers perspective that can only come from having lived through the midst of death and destruction.For an open, candid and transparent conversation about the reality of working and functioning through a war, we're thankful to have had this conversation.Check out the show notes here: https://mobileuseracquisitionshow.com/episode/marketing-wartime-ukraine-nataliia-drozd/KEY HIGHLIGHTS:
Preston Pysh is a co-founder of The Investor Podcast Network. In this interview, we discuss the ongoing trauma following FTX's unprecedented fall from grace, the implications for Bitcoin, and the ever-worsening macro situation where central banks are losing the battle to protect society from excessive government spending. - - - - The FTX drama is still being played out, and it will continue to do so for the weeks, months and years ahead. It feels as though we're still in the shock stage, trying to wrap our heads around not only what happened, but how such a seemingly fragile situation was allowed to get so out of control. Fingers are being pointed, defences prepared, and, even whilst we're still very early in this process, histories are already being rewritten. And yet, the broader economic picture remains the same: a conveyer belt of crises continue to buffet the global economy. Stagnation, growing inflation, mountainous debt, extreme stress in the bond markets, globalisation, and currencies under strain; there is a wall of mounting issues that are building into what seems to be an existential situation for the fiat system. The fundamental issue at hand is that nobody can tell what is up or down in relation to our economy. Price and value have been artificially inflated that they lack any purposeful meaning. Cheap money has enabled massive consolidation making the business environment top-heavy. And inflation has directed citizens to engage in rampant consumption, which results in a myriad of adverse downstream consequences. Both situations, i.e. the imploding of cryptocurrency and the mess of the global economy, have the same mitigation. Reaffirmation of the Bitcoin ideology will enable those with true convictions to begin repairing the damage caused by FTX. Bitcoin will also help the economies to align with reality, thereby facilitating better decisions. Whilst Bitcoin doesn't necessarily fix everything, it is the path to creating a better world.
“When you look at prices as they're trying to destroy demand, the thing that people aren't talking about is are they destroying supply faster; and if they are, prices aren't coming down, they might actually keep going up.”— Preston PyshPreston Pysh is a co-founder of The Investor Podcast Network. In this interview, we discuss the ongoing trauma following FTX's unprecedented fall from grace, the implications for Bitcoin, and the ever-worsening macro situation where central banks are losing the battle to protect society from excessive government spending.- - - - The FTX drama is still being played out, and it will continue to do so for the weeks, months and years ahead. It feels as though we're still in the shock stage, trying to wrap our heads around not only what happened, but how such a seemingly fragile situation was allowed to get so out of control. Fingers are being pointed, defences prepared, and, even whilst we're still very early in this process, histories are already being rewritten.And yet, the broader economic picture remains the same: a conveyer belt of crises continue to buffet the global economy. Stagnation, growing inflation, mountainous debt, extreme stress in the bond markets, globalisation, and currencies under strain; there is a wall of mounting issues that are building into what seems to be an existential situation for the fiat system. The fundamental issue at hand is that nobody can tell what is up or down in relation to our economy. Price and value have been artificially inflated that they lack any purposeful meaning. Cheap money has enabled massive consolidation making the business environment top-heavy. And inflation has directed citizens to engage in rampant consumption, which results in a myriad of adverse downstream consequences. Both situations, i.e. the imploding of cryptocurrency and the mess of the global economy, have the same mitigation. Reaffirmation of the Bitcoin ideology will enable those with true convictions to begin repairing the damage caused by FTX. Bitcoin will also help the economies to align with reality, thereby facilitating better decisions. Whilst Bitcoin doesn't necessarily fix everything, it is the path to creating a better world.- - - - This episode's sponsors:Gemini - Buy Bitcoin instantlyLedn - Financial services for Bitcoin hodlersBitcasino - The Future of Gaming is hereFidelity - Careers in cryptoLedger - State of the art Bitcoin hardware walletWasabi Wallet - Privacy by defaultTexas Blockchain Summit - Nov 17-18, 2022 | Austin, TexasBCB Group - Global digital financial Services-----WBD581 - Show Notes-----If you enjoy The What Bitcoin Did Podcast you can help support the show by doing the following:Become a Patron and get access to shows early or help contributeMake a tip:Bitcoin: 3FiC6w7eb3dkcaNHMAnj39ANTAkv8Ufi2SQR Codes: BitcoinIf you do send a tip then please email me so that I can say thank youSubscribe on iTunes | Spotify | Stitcher | SoundCloud | YouTube | Deezer | TuneIn | RSS FeedLeave a review on iTunesShare the show and episodes with your friends and familySubscribe to the newsletter on my websiteFollow me on Twitter Personal | Twitter Podcast | Instagram | Medium | YouTubeIf you are interested in sponsoring the show, you can read more about that here or please feel free to drop me an email to discuss options.
This week, please join authors Kevin Roedl and Sebastian Wolfrum, as well as Associate Editor Mark Link as they discuss the article "Temperature Control After In-Hospital Cardiac Arrest: A Randomized Clinical Trial." Dr. Carolyn Lam: Welcome to Circulation on the Run, your weekly podcast summary, and backstage pass to the Journal and its editors. We are your cohosts. I'm Dr. Carolyn Lam, Associate Editor from the National Heart Center, and Duke National University of Singapore. Dr. Greg Hundley: And I'm Dr. Greg Hundley, Associate Editor and Director of the Pauley Heart Center at VCU Health in Richmond, Virginia. Well, Carolyn, this week's feature, very interesting, a randomized clinical trial of temperature control after in-hospital cardiac arrest. But before we get to that exciting study, let's grab a cup of coffee, and jump in and discuss some of the other articles in the issue. Carolyn, would you like to go first? Dr. Carolyn Lam: Yes. Starting with a great quiz. So Greg, which is better? How about this? It's multiple choice. Is it A; transradial, or B; transfemoral access, in terms of post-procedural mortality? Dr. Greg Hundley: I'm going to go with transradial. It has been, hopefully, I'm okay on this. It just seems so many fewer complications. Dr. Carolyn Lam: But that's exactly that we need to meta-analyze the studies that have been done. Exactly what this paper did, led by Professor Valgimigli, from USI in Lugano, Switzerland. So what they did is, they performed an individual patient data meta-analysis of 21,600 patients, enrolled in seven multi-center randomized control trials, comparing the transradial with transfemoral access, among patients undergoing coronary angiography with or without PCI. And they found that transradial access was associated with a lower incidence of the primary outcome of all-cause mortality, and the co-primary outcome of major bleeding at 30 days, compared to transfemoral access. There was also evidence for reductions in major adverse cardiac and cerebral vascular events, net adverse clinical events, vascular complications, excess site bleeding, and blood transfusion. MI, stroke, and stent thrombosis, did not differ. And crossover was higher in the transradial access group. At predefined subgroup analysis, the authors confirmed that the benefit observed the transradial group was generally consistent across the majority of pre-specified subgroups, except for those with significant baseline anemia. Patients with baseline anemia appear to derive a substantial mortality benefit with transradial access rather than transoral access, compared to those with mild or no anemia. So, the authors concluded, that the meta-analysis provides evidence that transradial access should be considered the preferable access site for PCI, in patients with acute coronary syndrome, supporting most recent recommendations on the preferential use of this radial approach. So you were right, Greg. Dr. Greg Hundley: Very nice, Carolyn. A really important piece of science to disclose to our listeners, in that hurried state, and moving quickly door to balloon times, et cetera. And here we find another positive outcome in study result for transradial approaches. Well Carolyn, as we know, my next paper, it's really going to come to us from the world of preclinical science. And it pertains to hypertension, which is a common cardiovascular disease, and is related to both genetic and environmental factors. But the mechanisms linking the interplay between the domains of genetics and the environment have not been well studied. Now, DNA methylation, a classical epigenetic modification, not only regulates gene expression, but is also quite susceptible to environmental factors. Thereby, linking environmental factors to genetic modifications. So therefore, Carolyn, these authors, including Professor Jingzhou Chen, from Fuwai Hospital, National Center for Cardiovascular Diseases, and the Chinese Academy of Medical Sciences, and the Peking Union Medical College, and their colleagues, felt that screening differential genomic DNA methylation, in subjects with hypertension, would be important for investigating this genetic environment interplay in hypertension. So this study, Carolyn, like many from the world of preclinical science and circulation, incorporated both human and animal model subjects. Methodologically differential genomic DNA methylation in hypertensive, pre-hypertensive, and healthy control individuals, was screened using the Illumina 450K BeadChip, and then verified by pyrosequencing. Plasma oviduct glycoprotein 1, or OVGP1 levels, were determined using an enzyme-linked immunosorbent assay. And OVGP1 transgenic and knockout mice were generated to analyze the function of OVGP1. Dr. Carolyn Lam: Wow. Nice approach, Greg. And what did the authors find? Dr. Greg Hundley: Right, Carolyn. These authors found a hypomethylated site at cg20823859 in the promoter region of OVGP1, and the plasma OVGP1 levels were significantly increased in hypertensive patients. This finding indicates that OVGP1 is associated with hypertension. Now Carolyn, in OVGP1 transgenic mice, OVGP1 over expression caused an increase in blood pressure. Also, dysfunctional vasoconstriction, and vasodilation, remodeling of the arterial walls, and increased vascular superoxide stress and inflammation. And these phenomenon were exacerbated by angiotensin II infusion. In contrast, OVGP1 deficiency, attenuated angiotensin II induced vascular oxidase, stress, inflammation, and collagen deposition. Now pull down, and co-immunoprecipitation assays showed that myosin heavy chain 2A, or MYH9, interacted with OVGP1. Whereas, inhibition of MYH9 attenuated OVGP1 induced hypertension and vascular remodeling. Dr. Carolyn Lam: So Greg, let me try to summarize, is that okay? So hypomethylation, at that specific site in the promoter region of the OVGP1 gene, is associated with hypertension, and induces its upregulation. The interaction of this OVGP1 with myosin heavy chain 2A contributes to vascular remodeling and dysfunction. And so, OVGP1 is a pro hypertensive factor, that promotes vascular remodeling by binding to this myosin heavy chain. So, really cool stuff. Thanks for teaching us. Dr. Greg Hundley: Very good. Dr. Carolyn Lam: Well thanks so much, Greg. And we go back to the clinical world now, and ask the question, what is the efficacy and safety of prophylactic full dose anticoagulation and antiplatelet therapy, in critically ill COVID-19 patients? So I'm going to tell you the results of the COVID-PACT trial. And this was a multi-center, two-by-two factorial, open label, randomized controlled trial, with blinded endpoint adjudication in 390 ICU level patients. So, severely ill patients with COVID-19, from 34 US centers. Patients were randomized to a strategy of full dose anticoagulation, or standard dose prophylactic anticoagulation. And in the absence of an indication for antiplatelet therapy, patients were additionally randomized to either clopidogrel or no antiplatelet therapy. Dr. Greg Hundley: Ah, Carolyn. So what did they find? Dr. Carolyn Lam: Full dose anticoagulation substantially reduced the proportion of patients experiencing a venous or arterial thrombotic event, and there was no benefit from treatment with clopidogrel. Severe bleeding events were rare, but numerically increased in patients on full dose versus standard dose prophylactic anticoagulation, without any fatal bleeding events, GUSTO moderate or severe bleeding was so significantly increased with full dose anticoagulation, but with no difference in all-cause mortality. So in summary, in a population of critically ill patients with COVID-19, a strategy of prophylaxis with full dose, versus standard dose prophylactic anticoagulation, but not the addition of clopidogrel, reduced thrombotic complications, with an increased risk of bleeding, driven primarily by transfusions in hemodynamically stable patients, with no apparent excess in mortality. Dr. Greg Hundley: Very nice, Carolyn. What a important piece of information, as many of us around the world are taking care of critically ill patients with COVID-19. Well, how about we see what is in the mail bag this week? So first, Carolyn, there's a Frontiers piece by Dr. Packer, entitled, “Critical Reanalysis of the Mechanisms Underlying the Cardiorenal Benefits of SGLT2 inhibitors, and Reaffirmation of the Nutrient Deprivation Signaling Autophagy Hypothesis.” Next, there's a Research Letter, from Professor Airaksinen entitled, “Novel Troponin Fragmentation Assay to Discriminate Between Troponin Elevations in Acute Myocardial Infarction and End-stage Renal Disease.” Carolyn, there's another Research Letter, from Professor Solomon, entitled, “Aptamer Proteomics for Biomarker Discovery in Heart Failure with Reduced Ejection Fraction.” Also, Carolyn, [a] wonderful Cardiovascular News summary from Tracy Hampton, reviewing three articles. First, “Mechanisms Behind Cannabis Effects on Heart Health.” The second, “Exercise Inducible Metabolite Suppresses Hunger.” And then lastly, “Piezo1 Initiates the Cardiomyocyte Hypertrophic Response to Pressure Overload.” Dr. Carolyn Lam: Cool. There's also an exchange of letters between Doctors Jha and Borlaug on latent pulmonary vascular disease in therapeutic atrial shunt. And finally, an On My Mind, by Dr. David Kass entitled, “What's EF Got To Do, Got To Do With It.” I love it. You must read it. It's so, so cool. All right. But now, let's go on to our feature discussion, shall we? Dr. Greg Hundley: You bet, Carolyn. Welcome listeners, to our feature discussion today, and really delving into the world of in-hospital cardiac arrest, and how we manage those patients. And we have with us today, Dr. Kevin Roedl from Hamburg, Germany, Dr. Sebastian Wolfrum from Lubeck, Germany, and our own associate editor, Dr. Mark Link from University of Texas Southwestern in Dallas, Texas. Welcome gentlemen. Kevin, we're going to start with you. Can you describe for us, some of the background information that went into the construct of your study, and what was the hypothesis that you wanted to address? Dr. Kevin Roedl: Thank you, Greg. We thank you for the kind invitation to this podcast. We're very likened to do this podcast with you. And so, talking about the background of hypothermia in-hospital cardiac arrest, we have to go back like two decades almost, because there were two studies in New England Journal of Medicine published 2002, who introduced mild therapeutic hyperthermia to the treatment in post cardiac arrest. Primary, these two studies show the benefit of the therapy in this kind of patients. And then, 2003, it was introduced in also the international guidelines. However, these studies only addressed out-of-hospital cardiac arrest patients, and also, only shockable rhythms. And so, the question arised over the years, what about other patients like non shockable rhythms, or also in-hospital cardiac arrest? And so, that's basically was the primary aim of our study to address this special population. Because when you see the states, the numbers, there are 290,000 in-hospital cardiac arrests a year. So it's actually, a very large population. And there's no randomized control trial to show any benefit, or maybe harm, in this group. There were some observational studies, 2016 in China published. From China, in this group, they looked at the Get With The Guidelines registry, and actually, they saw that there was probably a negative influence of hypothermia in the study. However, it was only observational. So actually, there were no randomized control trials. And that primary hypothesis was, that we wanted to know actually, does thus mild therapeutic hyperthermia work in this group of patients in the in-hospital cardiac arrest setting? And what is the outcome? Is it like in the out-of-hospital cardiac arrest setting, or not? Dr. Greg Hundley: Wonderful, Kevin. And so, can you describe for us then, your study population and your study design? Dr. Kevin Roedl: Yes, of course. We did a randomized control trial. There were over 1000 people screened, and overall, we included 242. So you see how hard it is to get people in there. And actually, in terms of hypothermic temperature control, we are 120 about, and long term at 118, and the final others of the endpoints. And when we look at the baseline characters of these patients, they were well balanced actually, about 72 years. When we look at the initial cardiac arrest rhythm, that's interesting because about 70% non-shockable rhythms, and 25% shockable rhythms. And probably also interesting, the location of the cardiac arrest. Medical boards about 50%, and ICU or ED was 22%. So that's probably summed up the baseline characteristics of our study. Dr. Greg Hundley: Perfect. And so Kevin, can you describe for us what was the hypothermic target for the group that was going to have their temperature recused? Dr. Kevin Roedl: Yes, hypodermic target was 32 degrees to 44. And so two degrees Celsius, basically the same target like in earlier trials. Dr. Greg Hundley: Very nice. Well listeners, now we're going to turn to our second co-author, Dr. Sebastian Wolfrum. And Sebastian, can you share with us the study results? Dr. Sebastian Wolfrum: Yes, Greg. Thank you very much for the opportunity to participate in this podcast. Only wanted to include unconscious patients, and therefore, we took a time and took 45 minutes after their cardiac arrest, to let the patients get away if they did so. We also excluded patients that had severe functional deficit before the cardiac arrest; since we could not really define the neurological outcome if we would've included those. And we didn't see any differences. Neither in mortality, not in the functional outcome, either when they're treated with 33 degrees Celsius, or whether normothermia was used. The death rate after six month was in a range which is comparable to other in-hospital cardiac arrest studies, and higher than those performed in the out-of-hospital cardiac arrest studies. It was about slightly over 70% in both groups. And the number of patients with the good functional recovery after six months was 23% of the patients in the hypothermia group, and 24% of the patients in the normothermia group. And if we look at only the survivors, we see that the ones which are worse functional outcome, were most of them dead after six months. We then also focused on the temperature curves in our patients, and to see whether we have achieved our goal. And we saw that we have reached the target temperature within four and a half hours after cardiac arrest in our hypothermia group. Which is not as fast that we had expected, but still in the range, which is comparable to other studies on this field. And we also saw that our control group was about 37 degrees, within the first 12 and 48 hours. So we truly avoided fever, which has not been done in every previous study on cardiac arrests. Dr. Greg Hundley: Very nice. And any differences between the hypothermia and normothermia groups, related to the age of the patient? Or, whether or not they had a shockable rhythm at the time of presentation? Dr. Sebastian Wolfrum: We saw as a result of our study, that age is a predictive factor for mortality. But age did not differ between our treatment groups, and therefore, did not interfere with our results. And we didn't see differences in the shockable or non-shockable rate in our patients in the different treatment groups. Dr. Greg Hundley: Thank you. Well listeners, now we're going to turn to our associate editor, Dr. Mark Link, one of our expert electrophysiologists at Circulation. And Mark, you have many papers come across your desk, and what attracted you to this particular paper? Dr. Mark Link: There were a number of things. One, it's hard to do RCTs in resuscitation, and I thought they did a very nice job with this RCT. Two, the subject of hypothermia, or therapeutic temperature management, is a very hot one in resuscitation. It's one of the few treatments in the past that have been shown to make a difference in outcome. And so, all of those trials were done in out-of-hospital arrest. So to have a trial done in in-hospital arrest was very intriguing also. And I think we're all disappointed that it wasn't a positive trial, but we have to take the negative trials also. And I think, part of the reason it may have been a negative trial is because the normal thermic group avoided hyperthermia. And I think that's something that's coming out of a lot of these trials is avoid fever. It may not be so important to get hypothermic targets, actually, looks like it's probably not, but it looks like it's very important to avoid fever. Dr. Greg Hundley: Very nice. Well listeners, we're going to turn back to our expert panel here really, and start with you Kevin. Kevin, what do you think is the next study that needs to be performed in this sphere of research? Dr. Kevin Roedl: Thank you for this interesting question. Yeah, a bunch of studies could be performed, especially maybe in the out-of-hospital cardiac arrest study, because we don't know. This fever harmful, we have to find certain subgroups in which this treatment works. So maybe in this subgroups there is data on this and it could be a benefit. So these are, I think, the two main topics that should be done in the future. Dr. Greg Hundley: Thank you. Sebastian, what are your thoughts? Dr. Sebastian Wolfrum: As Mark said, the hypothermic treatment was, for decades, maybe the only treatment which we could give to cardiac arrest patients, which has been proven to reduce mortality. And all other studies following didn't see any be benefit of hypothermia, not even in a subgroup. Also, the TTM trials did not. So I'm questioning myself, where is the original HACA study group that benefits? Where did this hide in the other studies? So I would think, to do another study in out-of-hospital cardiac arrest patients, whether in ventricular fibrillation that had shown in the HACA trial to reduce mortality. This should be done in a similar way to the original study, to see whether there is this subgroup. People who support the idea of hypothermia also focus very much on the fast onset of their hypothermic treatment. And they say we saw a difference in mortality in the HACA trial, and we could very fast. And I think the other studies have to show that they cool as fast as the HACA study. So the main focus should be on the time calls of hypothermia after cardiac arrest, cooling very fast to a target temperature of 33 degrees, maybe holding on for 24, maybe 48 hours. Dr. Greg Hundley: Very nice, Sebastian. So focusing on the speed and the timing of that cooling. And Mark, anything to add? Dr. Mark Link: Yeah, so if I sit here with my writing group hat on for the HA and say, "What are we going to do for the resuscitation guidelines in 2025?" I think you look at the totality of the data for targeted temperature management. And I think, the main thing you say, walking away from this, is avoid fever. Don't let your patients get hot. I'm not sure you can say much more than that right now, until we get more data. Dr. Greg Hundley: Very nice. Well listeners, a really interesting provocative discussion today. And we want to thank Dr. Kevin Roedl from Hamburg, Germany, Dr. Sebastian Wolfrum from Lubeck, Germany, and our own associate editor, Dr. Mark Link from Dallas, Texas, bringing us the results of this study highlighting that hypothermic temperature control is compared with normothermia did not improve survival, nor functional outcome, at 180 days in patients presenting with coma after in-hospital cardiac arrest. Well, on behalf of Carolyn and myself, we want to wish you a great week, and we will catch you next week On The Run. This program is copyright of the American Heart Association 2022. The opinions expressed by speakers in this podcast are their own, and not necessarily those of the editors, or of the American Heart Association. For more, please visit ahajournals.org.
Gospel of Mark 3:7-19
Synopsis On today's date in 1971, the John F. Kennedy Center for the Performing Arts in Washington, D.C., was inaugurated with a gala performance of a new work by Leonard Bernstein. Entitled “Mass,” this was a musical and visual extravaganza which reinterpreted the text of the Latin liturgy and involved more than 200 singers, dancers, and instrumentalists. Jacqueline Kennedy Onassis had asked Bernstein to write a piece to open the new Center but was conspicuous by her absence. President Richard Nixon also chose to stay away, rightly fearing that Bernstein's “Mass” would be interpreted as an embarrassing protest against the war in Vietnam. The Washington Post's front-page review, titled “A Reaffirmation of Faith,” was glowing in its praise, but Time magazine's assessment was condescending, quoting some New York wits who dubbed it the “Mitzvah Solemnis.” The New York Times review was brutal, calling Bernstein's Mass “a combination of superficiality and pretentiousness . . . [and] the greatest mélange of styles since the ladies' magazine recipe for steak fried in peanut butter and marshmallow sauce.” But Jacqueline Kennedy Onassis, when she finally did hear Bernstein's work, sent the composer an inscribed photograph which read: “Lenny – I loved it, yes, I did, and I love you, too. Thank you for making ‘Mass' so beautiful.” Music Played in Today's Program Leonard Bernstein (1918-1990) –Sanctus, from Mass (Empire Brass) Telarc 80159 Leonard Bernstein (1918-1990) –Simple Song, from Mass (Boston Pops; John Williams, cond.) Philips 416 360
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