Podcasts about structure function

7 million children have been diagnosed with ADHD, with over half of those children taking prescription medications.  But Dr. Prather says that the Structure-Function approach gets to the actual root cause of the symptoms instead of just masking the symptoms with prescriptions.  In this episode, we talk about:—How ADHD is caused by a neurotransmitter abnormality that's going on, where the brain does not work as it should.—Why Dr. Prather believes there is an actual increase in ADHD, not just more cases due to heightened awareness. —The diagnostics Dr. Prather recommends to get to the root cause of ADHD symptoms, including a Hair Analysis and a G.I. Stool Kit.  And the Neurotransmitter and Neural Zoomer Tests that reveal exactly what is going on in the brain and how to correct it.—The role of parasites in causing mental health issues.  And the amazing story of how Dr. Prather helped a boy go from being recommended for Special Education class to being accepted into a Gifted program after his parasites were cleared up. —How boys are more likely to be affected by Heavy Metal Toxicities, which are well-known to change the brain chemistry.  And how girls are more likely to have Copper toxicities and Iron deficiencies that will result in changes in personality and academic performance.—Why the diet is a huge factor in ADHD and the dietary recommendations for the best results.—The list of Vitamins, Minerals, Natural Supplements and Homeopathics that improve focus and attention.  And how Chiropractic and Acupuncture are important treatments that "make an immediate, quick, and long-term change in a child's performance".—The well-known evidence for how taking ADHD medication as children can lead to drug addiction when they become adults.  And why researchers said that ADHD drugs were more for the benefit of parents and teachers, not the children.—The dangerous side-effects of ADHD medications, including:  weight loss, loss of appetite, stunted growth, difficulty sleeping, drowsiness, anxiety, abdominal problems, fatigue, heart problems, hypertension, skin issues, involuntary tics, and psychosis. —Plus, learn how you can get 20% off our Neurotransmitter and Neural Zoomer Test that measures brain chemicals and imbalances by attending our upcoming free educational seminar with Dr. Prather this Wednesday, May 28th at 6:30 p.m.http://www.TheVoiceOfHealthRadio.com

Dr. Prather previews his upcoming free Holistic Integration educational seminar this Wednesday, April 30th at 6 p.m.  In this episode, we talk about:—The first two things in our body that Dr. Prather always says you need to get fixed if you want to get healthy.   —How your hormones determine your weight, your mood, your overall health and well-being, and how well you age.  And how hormone imbalance can even impact your sleep and can cause insomnia. —The reason women have far more complex hormones to balance for mood compared to men, who are "simple creatures".—Why Dr. Prather says that doctors "aren't smart enough" to regulate all of the hormones of the body.  And the Structure-Function approach he uses to help the BODY to be the hero and balance the hormones itself.—The Testosterone levels men should have in order to function.  And why men with low Testosterone usually have to be brought into a doctor's office by someone else for help because they have "crashed" and don't have the motivation to come in themselves. —Why Dr. Prather says that "beauty is the result of a good Hormonal system".  And how women are attracted to different types of men based upon where they are at in their monthly cycle. —The Herbals, Glandulars, Vitamins, Minerals, and Homeopathics that can help to naturally balance Hormones.  And why Dr. Prather says that only 2% of the time should patients actually be given prescription Hormones. —How the Atlas Orthogonal Chiropractic Adjustment at Holistic Integration is "the number one thing" when it comes to balancing out the Endocrine System. —Why Acupuncture is helpful for stimulating healing of your Hormone system, including the relief of excruciating pain from cystic ovaries within minutes.—How you can ask Dr. Prather questions and receive 20% off of our thorough Hormone test by attending Dr. Prather's free seminar this Wednesday night, either in person or on ZOOM.http://www.TheVoiceOfHealthRadio.com

20% of all adults suffer from chronic pain, while up to 80% will experience acute pain from injury or surgery.   $600 billion is spent annually in health care costs and loss of productivity due to pain.  In this episode, you'll discover:—Dr. Prather's theory that pain comes from a blockage of energy in one or more of The 5 Pathways Of Pain.  And how each pathway needs to be treated in a different way. —Why Dr. Prather says his patients will first feel an increase in their energy level before they feel a decrease in their pain level.—How 80% of chronic Headache patients have actually given up on finding a solution, but Dr. Prather says that his office is "pretty much 100% successful" with Headaches.—The difference between the medical approach of pain management that masks the symptoms versus the Structure-Function approach of actually fixing the underlying cause of the pain.—Why Opioids and NSAIDs actually "make the pain problem worse" long-term by damaging the body.  And the long list of natural, safe, non-pharmaceutical alternatives Dr. Prather uses in his office that produce better results than the drugs.—How the treatments offered by Holistic Integration are exactly what an independent government commission recommended as the best approach to pain…until the pharmaceutical companies interfered.—Why Dr. Prather says that "Chiropractic is one of the best things you can do" when you're talking about pain relief.  And the reason why Holistic Integration begins with making sure the Atlas is in its proper position.—How Acupuncture "can actually reverse" Opioid addiction by stimulating the body's own natural Opioid production.  And how "everybody" has some issues with a blockage of their Electromagnetic pathway, which makes the biggest difference for Chronic Pain patients.—The link between the Lymphatic pathway of pain and Fibromyalgia, for which Dr. Prather's office gets "remarkable results".  And how the B Vitamins are particularly effective for Nerve Pain. —The Cerebrospinal Fluid blockage that is "easy to diagnose" and is "a different type of pain" which responds well to Craniosacral Therapy at Holistic Integration.  And how Dr. Prather considers a lot of the deep joint pain as a blockage of the Circulatory pathway, which can be treated by "pumping" the joint.http://www.TheVoiceOfHealthRadio.com

The skin is the largest organ in the body and is often a reflection of what is going on in someone's health.  In this episode, you'll discover:—Why Dr. Prather says you don't want to put anything on your skin that you wouldn't eat. —The Structure-Function approach Dr. Prather uses to discover the root cause of a patient's skin issues versus the Disease Care approach that focuses more on just treating the symptoms. And why complete diagnostics are critically important to find the underlying cause of the skin problems.—How Dr. Prather discovered parasites as the root cause of a 4-year-old boy who was covered head-to-toe with Eczema since birth.  And the "well-known" connection between gut health and the skin. —Why Dr. Prather says that a "weakened immune system will translate into skin problems".  And why taking an antibiotic or pharmaceutical, while necessary at times, can be harmful for your immune system and make your skin worse.—The importance of a healthy Liver for giving your skin that "healthy glow".  And why Dr. Prather refers to the skin as "a second Liver".—How "an imbalance in the Endocrine System will result in Acne".  And how prescribing birth control pills to control Acne is not getting to the root cause of the Acne and can result in other long-term issues for young women.—How food allergies are critical to skin health.  And how Holistic Integration can test to find out which foods are harmful for you individually and which foods are "actually like medicine" for your body.—The Vitamins and Minerals most critical for skin health.  And why Horsetail Tea is a secret to beauty and anti-aging for your skin, hair, and nails.—Why Chiropractic and Acupuncture are so helpful for those with skin conditions.  And how Red Laser Acupuncture has been used in Dr. Prather's office to reverse Vitiligo. —Plus, you'll hear from local entrepreneur Meredith Sharp of TallowSkinBalm.com about how you can receive a 10% discount on all-natural holistic skin care products by using the coupon code: HOLISTICINTEGRATIONhttp://www.TheVoiceOfHealthRadio.com

Structure-Function Health Care (as opposed to Disease Care) is a non-pharmaceutical and safe approach to health for pregnant Moms. In this episode, you'll learn:—Why Structure-Function Care is important for women BEFORE they get pregnant in order to detox the body from heavy metal toxicities or deal with certain gut infections that can't really be dealt with during pregnancy.—How Zinc deficiency can cause Infertility and impact the development of the baby.—The emphasis of diagnostics at Holistic Integration and the reason diagnostics are even more important in the Structure-Function Health Care Model compared to the Disease Care Model. And the shocking fact about how "reference ranges" on lab tests have NOTHING to do with your health.—How almost all women become Anemic during pregnancy. And how Anemia can impact the immune system and intelligence of the developing baby.—The correlation of kidney health to pre-eclampsia and eclampsia. And how to avoid these conditions through proper protein intake.—The value of eating liver (or taking liver capsules!) while pregnant for the health of the baby. And what the placenta reveals about the health of the pregnancy.—How Hemorrhoids can be avoided during pregnancy. And where Hemorrhoids come from. (Not there!)—Why Iodine has been proven to be the biggest factor in your child's I.Q. And its impact on the child's future Thyroid health.—Why nutritional supplementation is so important for pregnant women. And why Dr. Prather says prenatal vitamins are "the bare minimum" required.—The importance for Chiropractic care during pregnancy to help women keep comfortable and have a smoother delivery. Plus, how there are "happy baby" Acupuncture points that help both Moms and babies.http://www.TheVoiceOfHealthRadio.com

1-in-6 couples globally suffer from the heartbreak of Infertility, with the numbers being closer to 1-in-5 couples in America.  But Dr. Prather has an amazing success record helping couples through the Structure-Function approach to health care.  In this episode, find out:—Why the Structure-Function focus on getting people healthier is needed for Infertility because "a healthy person can have babies and an unhealthy person has trouble having babies". —The story of Dr. Prather's Chiropractor grandfather and his patients who found results for infertility through Chiropractic adjustments alone.—How Acupuncture "has the highest success rate of any treatment for infertility", particularly when it comes to helping underlying issues of inflammation and endometriosis.  And how Dr. Prather even uses a special Acupuncture protocol to flip a breech baby into proper delivery position!—Why getting the Zinc-Copper ratio balanced out makes "a big difference in infertility".  And the crucial role of Folic Acid, Vitamin D, and Iodine, which fertility clinics usually don't even look at.—How Infertility is an issue that requires BOTH the man and the woman to get healthy and is not just a female issue. —Why genetic defects can be prevented by focusing on the nutritional deficiencies during pregnancy. —How Dr. Prather's approach helps couples in all three phases:  getting pregnant, avoiding miscarriage, and a smoother delivery.—The diagnostics Dr. Prather recommends to get to the root cause of fertility issues. —How you can do both IVF and Structure-Function Care at the same time, but Dr. Prather always encourages couples to try the natural approach first before going though the extreme expense and hardship of IVF. —And you will not want to miss the sweet and inspiring story of Seth and Rachel about how Holistic Integration helped them bring their newborn son, Cal, into the world.http://www.TheVoiceOfHealthRadio.com

This week, Dr. Prather answers a question people often ask of his patients who refer them to his office.  In this episode, we talk about:—How people often don't understand how their condition can be helped by someone who is licensed as a Chiropractor.  But how their skepticism usually disappears after their first patient exam.—The Diplomate of the American Board Of Chiropractic Internists (D.A.B.C.I.), 3-year post-graduate program that Dr. Prather went through, which only about 5% of students even complete.—Why Dr. Prather says, “If you don't want diagnostics done, then don't come to me."  And how his office offers more thorough diagnostics "than probably any place you've ever been", including for patients who previously went to places like the Mayo Clinic and Johns Hopkins.—The difference between pharmaceutically-based Disease Care and the Structure-Function Care practiced at Holistic Integration.  And why Dr. Prather says he doesn't treat diseases, but focuses on trying to take care of the underlying cause to the disease and helping the body to work as well as it possibly can. —How 80% of Health Care should be Structure-Function based and 20% of Health Care should be Disease Care based.  And the long-term insurance company study that proved how having a Structure-Function doctor as your primary physician will improve patient outcomes by 85% and reduce health care costs by 60%.—Why EVERYONE should have three basic lab tests every year:  Prather Profile Blood Analysis, Hair Analysis, and a Stool Kit.—How Dr. Prather saw a "huge improvement" in his patient results when he combined the Structural Care he was offering with Functional Care.  And why the combination of both Structure and Function produces results that cannot be duplicated by just Structural care or just Functional care alone. —Why Dr. Prather says that pharmaceuticals, while often necessary, "never make the body healthier" and that "only Structure-Function Care improves the overall health of the body".  And why Disease Care and Structure-Function Care should be working together.—The treatments classified as Structure-Function Care, such as:  Chiropractic, Acupuncture, herbs, nutraceuticals, vitamins, herbs, homeopathy, and Physiotherapy.  And how "everything and anything" can be helped by Structure-Function Care.—Plus, you will be delighted to hear from Mary, a patient of Holistic Integration who was a paramedic for 40 years.  And how Holistic Integration has helped her with multiple health issues. http://www.TheVoiceOfHealthRadio.com

Endometriosis is a painful and dangerous condition that affects 10% of all menstruating women and causes 50% of all fertility issues. In this episode, you'll discover:--The 80% greater likelihood for a woman to suffer from Endometriosis if they have a female family member who suffers from it. And why a girl starting her period later reduces her chance of Endometriosis, as well as other health problems.--The health benefits of exercise--especially jumping jacks!--in preventing Endometriosis, as well as early periods for young girls. And how higher body fat percentage increases risk of Endometriosis. --Why heavy periods indicate a woman probably has Endometriosis. And how pelvic pain indicates a 75% chance of Endometriosis.--How autoimmune diseases such as Hashimoto's Disease, Graves' Disease, Addison's Disease, Ulcerative Colitis, Crohn's Disease, and Fibromyalgia increase your chances of having Endometriosis.--Why the surgery for Endometriosis usually causes it to come back WORSE than it was before. And how the current medical options, such as birth control pills, aren't very effective.--How hormonal imbalance is the biggest cause of Endometriosis. Plus, the role of a weakened immune system, higher inflammatory rate, and chemical toxicity (such as high Copper) in Endometriosis.--The Structure-Function approach Dr. Prather uses in getting the body in proper balance so that the body itself can treat the Endometriosis. And the role thorough blood tests play in Dr. Prather's approach in getting to the root cause of Endometriosis.--The story of a patient who had been through In Vitro Fertilization Therapy THREE times with no results, but became pregnant after Acupuncture helped eliminate the inflammation of Endometriosis. And why Dr. Prather says Acupuncture "has been shown to be one of the very best treatments for Endometriosis to reduce the inflammation".--How Chiropractic care helps normalize the menstrual cycle and has helped the Endometriosis symptoms to "go completely away" for many patients Dr. Prather has treated. --How Holistic Integration tests "more thoroughly than almost anybody else" for hormone balance. And why the powerful hormone replacement therapies are only necessary in about 2% of the cases, while more natural approaches Holistic Integration uses are far more effective as they stimulate your body's own hormone production.www.TheVoiceOfHealthRadio.com

Dr. Prather says it's a misnomer to think that kids are naturally healthy. As children develop and grow, they actually need more support for their health. In this episode, you'll learn:—How very few children are in a normal range when Dr. Prather checks their blood work.—Why Japan has the best childhood mortality rates....yet the least amount of vaccinations for children.—The role of the Thymus as the center of a child's immune system, while an adult's is based on bone marrow.—How childhood obesity is an increasing problem. And the reason why Dr. Prather believes this is happening.—Why ADD, ADHD, and Autism Spectrum Disorders have dramatically increased in recent years in the U.S., but aren't found like that elsewhere in the world.—The Structure-Function approach to children's health care used at Holistic Integration that gets "better results with less risk" than the Disease Care model of drugs and pharmaceuticals.—Why antibiotics are a poor way to treat Otitis Media/ear infections. And the more effective Homeopathic medicines and natural treatments, like Chiropractic and Diathermy, that work better and quicker.—How Structure-Function Care can provide "amazing results" for childhood asthma by dealing with the underlying problem that causes the condition, such as parasitic infections.—The reason why Dr. Prather says children having parasites, chicken pox, or measles can actually help STRENGTHEN a child's immune system and can help DECREASE autoimmune diseases like Multiple Sclerosis.—How children absorb heavy metals four times faster than adults. And how Aluminum is the most common toxicity Dr. Prather sees in children, which affects their bones and causes learning disabilities.—Plus, you'll learn the 6 natural supplements every Mom should have in their medicine cabinet to keep their child's immune system up right now and how you can order all of them in our special Box Of Health for Kids.http://www.TheVoiceOfHealthRadio.com

October is Breast Cancer Awareness Month. This week, we talk about the most common Cancer in Women and the Structure-Function treatment options that can boost your odds of survival. In this episode, you'll learn:—The risk factors for Breast Cancer.—How breastfeeding reduces your chance of developing Breast Cancer. —The percentage of Breast Cancer cases due to genetic factors. And how most Breast Cancer can be avoided with lifestyle changes.—The herbs that are most helpful for fighting Breast Cancer. —The vitamins that are most helpful for treating painful and Fibrocystic breasts.—The recommended role of Chiropractic and Acupuncture for Breast Cancer patients, which can reduce adverse symptoms in patients by 80% (like hair loss, fatigue, and neuropathy).—Why Dr. Prather says Homeopathy provides the "quickest and most dramatic changes" in the body. —The crucial role the Lymph System plays for Breast Cancer. And why underwire bras should be avoided for good breast health.—The imaging options available for women. And why mammograms are controversial.—And in our "Restoring Hope" segment this week, you'll hear a powerful interview with Kim Biggerstaff of Ascent 121, an organization dedicated to helping the victims of child sex trafficking in Indianapolis. http://www.TheVoiceOfHealthRadio.com

Obesity is the number one disease process in America, with almost 60% of adults now having this issue. But most weight loss programs will actually result in you being heavier in 5 years than if you did nothing. In this episode, we talk about:—How focusing on Fat Loss is more important than just Weight Loss, because Weight Loss can include the loss of important muscle.—Why the body burns fewer calories the higher your body fat percentage goes.—How the Structure-Function approach to Fat Loss is focused on making you healthy and getting your body into Homeostasis.—Why the government was actually behind changing Americans from being "lean, mean, fighting machines" in the 1940's to being far heavier today.—The new experimental prescription drugs for weight loss that patients are asking about and the negative problems that are associated with them, including a measurable spike in ER visits, "saggy butt", "drooping face", and kidney issues.—Why diagnostics are crucial to know how to get the body working correctly so that it can begin to lose the fat.—The 8 Pillars of the DTS (Dedicate, Transform, Succeed) Fat Loss Program at Holistic Integration and how each of those pillars contribute to long-term, sustainable fat loss. —The Fit3D 3D Body Scan technology used at Holistic Integration to accurately measure your body fat and is used it track your progress. —How "supplements get your body back into Homeostasis and good nutrition keeps your body in Homeostasis".—The services offered through the DTS Fat Loss Program, including: Supplementation, Nutritional Consultation, Diathermy, Infrared Sauna, Lipo-Laser, Acupuncture, Auriculotherapy, and Personal Training.http://www.TheVoiceOfHealthRadio.com

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.08.04.551953v1?rss=1 Authors: Jimenez-Marin, A., Diez, I., Erramuzpe, A., Stramaglia, S., Bonifazi, P., Cortes, J. M. Abstract: The human brain is an extremely complex network of structural and functional connections that operate at multiple spatial and temporal scales. Investigating the relationship between these multi-scale connections is critical to advancing our comprehension of brain function and disorders. However, accurately predicting structural connectivity from its functional counterpart remains a challenging pursuit. One of the major impediments is the lack of public repositories that integrate structural and functional networks at diverse resolutions. Addressing this issue, we provide open datasets and code enabling the examination of the correspondence between structural and functional connectivities at different scales. We present a module-level strategy that overcomes region-level approaches in understanding the structure-function correspondence. Moreover, we also provide additional resources focused on neuro-genetic associations of module-level network metrics, which present promising opportunities to further advance research in the field of network neuroscience, particularly concerning brain disorders. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.18.549603v1?rss=1 Authors: Namgung, J. Y., Park, Y. J., Park, Y., Kim, C. Y., Park, B.-y. Abstract: Body mass index (BMI) is an indicator of obesity, and recent neuroimaging studies have demonstrated inter-individual variations in BMI to be associated with altered brain structure and function. However, how the structure-function correspondence is altered according to BMI is under-investigated. In this study, we combined structural and functional connectivity using Riemannian optimization with varying diffusion time parameters and assessed their association with BMI. First, we simulated functional connectivity from structural connectivity and generated low-dimensional principal gradients of the simulated functional connectivity across diffusion times, where low and high diffusion times indirectly reflected mono- and polysynaptic communication. We found the most apparent cortical hierarchical organization differentiating between low-level sensory and higher-order transmodal regions in the middle of the diffusion time, indicating that the hierarchical organization of the brain may reflect the intermediate mechanisms of mono- and polysynaptic communications. Associations between the simulated gradients and BMI revealed the strongest relationship when the hierarchical structure was most evident. Moreover, the functional gradient-BMI association map showed significant correlations with the cytoarchitectonic measures of the microstructural gradient and moment features, indicating that BMI-related functional connectome alterations were remarkable in higher-order cognitive control-related brain regions. Finally, transcriptomic association analysis provided potential biological underpinnings, specifying gene enrichment in the striatum, hypothalamus, and cortical cells. Our findings provide evidence that structure-function correspondence is strongly coupled with BMI when hierarchical organization is most apparent, and the associations are related to the multiscale properties of the brain, leading to an advanced understanding of the neural mechanisms related to BMI. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Infertility affects 10% of all Americans, equally divided between men and women (and is growing worse). But Dr. Prather talks about a natural approach that has a success rate between 80-90%. In this episode, find out:--Why Dr. Prather says the first approach to infertility should be focused on getting healthy before costly medical intervention like In Vitro Fertilization.--How most of Dr. Prather's infertility success stories already went through all the medical interventions (unsuccessfully) and how damaging to health those infertility treatments can be.--The diagnostics and lab tests Dr. Prather uses for infertile patients. Plus, why your gut health and your fat percentage are important indicators of your fertility.--Why the top Infertility clinics are incorporating Acupuncture. And what Dr. Prather says are the two things Acupuncture does to help Infertility patients.--How Chiropractic adjustments help fertility by balancing a woman's hormones and giving her a more regular menstrual cycle.--Why the toxins in our environment today make young people more likely to suffer from infertility than previous generations.--How the Structure-Function approach to Infertility that Dr. Prather uses causes patients to feel so much better in their overall health, while the conventional medical treatments can take a toll on a woman's body.--The correlation between vitamin and minerals deficiencies to infertility.--How Homeopathic Medicine helps target specific toxicities in the body that contribute to Infertility. And why Dr. Prather says this is an important treatment for his toughest cases.--How birth control pills contribute to Infertility.http://www.TheVoiceOfHealthRadio.com

Dr. Prather always says the correct balance in our Health Care system for optimal patient results is 80% Structure-Function Care and 20% Disease Care. In this episode, you'll find out:—The two different categories the FDA uses to classify health care: Disease Care and Structure-Function Care. And the true definition of "disease" that might surprise you. —How a product can only be defined as a pharmaceutical if it has the potential for harm.—Why a Structure-Function physician is correctly described as a "Health Doctor" as the goal is to bring balance or Homeostasis to the body.—The 8 Principles of Structure-Function care that Dr. Prather organized as "The 8 Pillars Of Perfect Health" to evaluate his patients. —Why Dr. Prather says the terms "Complementary" and "Alternative" Health Care are slurs that were designed to control the language by Disease Care practitioners. And the true origins of the term "quack". —How what is called "modern" medicine is actually based on the Egyptian and Asclepieion system. And how Pergamum referenced in the Book of Revelation was the center of this system. —The reason Dr. Prather says the philosophy of Structure-Function Care is "as old as time itself". And King Solomon's role in Structure-Function Care.—Why Dr. Prather says his office is trying to do something "that's never been done is history" by promoting a balanced Health Care system that combines the best of Disease Care with the best of Structure-Function Care.—How Nathan came into Holistic Integration due to redness and irritation on his eyelids, but discovered a previously-undiagnosed neck fracture and found relief from Migraine Headaches that he's had for years. —And in a very special treat, you'll get to hear from Jim, our X-Ray Technologist at Holistic Integration and a favorite of our patients.http://www.TheVoiceOfHealthRadio.com

90% of all anxiety drugs in the world are consumed by Americans. While prescription drugs have their place, our health care system has overused prescription drugs when there are drug-free alternatives. In this episode, we talk about:--Why you should see a Structure-Function doctor FIRST before seeking Disease Care (and the difference between the two types of care).--When the stress response becomes unhealthy ("DIStress") causing damage to your endocrine system, a fried nervous system, and harmful changes in the body.--How we can feel emotionally paralyzed (not being able to move forward or backward) and why it is called the "reptilian brain" response. --How too much Copper in your body can lead to an over-excited nervous system and over-excited endocrine system, leading to an improper stress response.--That Calcium-Magnesium imbalance, high Mercury, and high Lead all throw off proper stress response. And why having the appropriate lab tests is so important to determine these things.--Why Dr. Prather says 80% of the patients he sees are in the wrong "Fight-Flight" Sympathetic System mode where they have a "broken down endocrine system". --How to rebuild the nervous system, rebuild the endocrine system, and boost the body's immune system to battle anxiety through Functional Care. And the different products available (80,000!) that Dr. Prather uses to help renew and rejuvenate the body, including Nutritionals, Herbals, Flower Remedies, Homeopathics, Glandulars, and Mineral Balancing products.--The Structural Care options to treat Anxiety, such as Chiropractic and Acupuncture. Plus, how Auriculotherapy helps relieve Anxiety.--Why Dr. Prather calls it one of his "secrets to success" to combine Functional and Structural Care to achieve better patient outcomes.--How TMJ in your jaw involves a nerve that leads directly to your brain's emotional system. Plus, the role toxicity in your body plays in Anxiety and how Diathermy helps the body to detox.http://www.TheVoiceOfHealthRadio.com

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.14.520453v1?rss=1 Authors: Liu, Z.-Q., Shafiei, G., Baillet, S., Misic, B. Abstract: The relationship between structural and functional connectivity in the brain is a key question in connectomics. Here we quantify patterns of structure-function coupling across the neocortex, by comparing structural connectivity estimated using diffusion MRI with functional connectivity estimated using both neurophysiological (MEG-based) and haemodynamic (fMRI-based) recordings. We find that structure-function coupling is heterogeneous across brain regions and frequency bands. The link between structural and functional connectivity is generally stronger in multiple MEG frequency bands compared to resting state fMRI. Structure-function coupling is greater in slower and intermediate frequency bands compared to faster frequency bands. We also find that structure-function coupling systematically follows the archetypal sensorimotor-association hierarchy, as well as patterns of laminar differentiation, peaking in granular layer IV. Finally, structure-function coupling is better explained using structure-informed inter-regional communication metrics than using structural connectivity alone. Collectively, these results place neurophysiological and haemodynamic structure-function relationships in a common frame of reference and provide a starting point for a multi-modal understanding of structure-function coupling in the brain. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.24.517848v1?rss=1 Authors: Winter-Hjelm, N., Tomren, A. B., Sikorski, P., Sandvig, A., Sandvig, I. Abstract: Microfluidic devices interfaced with microelectrode arrays have in recent years emerged as powerful platforms for studying and manipulating in vitro neuronal networks at the micro- and mesoscale. By segregating neuronal populations using microchannels only permissible to axons, neuronal networks can be designed to mimic the highly organized and modular topology of neuronal assemblies in the brain. In vivo, the development of such neuronal assemblies is tightly orchestrated by reciprocal, dynamic structure-function relationships shaped by an interplay between intrinsic neuronal self-organizing properties and spatiotemporally regulated chemical and physical guidance cues. Engineered neuronal networks represent reductionist paradigms that can help recapitulate such dynamics in vitro. However, little is known about how the underlying topological features of such engineered neuronal networks contribute to their functional profile. To start addressing this question, a key parameter is control of afferent or efferent connectivity within the engineered network. In this study, we show that a microfluidic device featuring axon guiding channels with geometrical constraints inspired by a Tesla valve effectively promotes unidirectional axonal outgrowth between neuronal nodes, thereby enabling us to control afferent connectivity. We verified this by applying designer viruses to fluorescently label the neurons to visualise the structure of the networks, combined with extracellular electrophysiological recordings using embedded nanoporous microelectrodes to study the functional dynamics of these networks during maturation. We furthermore show that electrical stimulations of the networks induce signals selectively transmitted in a feedforward fashion between the neuronal populations. This model system has the potential to provide novel insights into the development, topological organization, and neuroplasticity mechanisms of neuronal assemblies at the micro- and mesoscale in healthy and perturbed conditions. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.20.512802v1?rss=1 Authors: Fotiadis, P., Cieslak, M., He, X., Caciagli, L., Ouellet, M., Satterthwaite, T. D., Shinohara, R. T., Bassett, D. S. Abstract: Recent work has demonstrated that the relationship between structural and functional connectivity varies regionally across the human brain, with reduced coupling emerging along the sensory-association cortical hierarchy. The biological underpinnings driving this expression, however, remain largely unknown. Here, we postulated that intracortical myelination and excitation-inhibition (EI) balance mediate the heterogeneous expression of structure-function coupling (SFC) and its temporal variance across the cortical hierarchy. We employed atlas- and voxel-based connectivity approaches to analyze neuroimaging data acquired from two groups of healthy participants. Our findings were consistent across processing pipelines: 1) increased myelination and lower EI-ratio associated with more rigid SFC and restricted moment-to-moment SFC fluctuations; 2) a gradual shift from EI-ratio to myelination as the principal predictor of SFC occurred when traversing from granular to agranular cortical regions. Collectively, our work delivers a novel framework to conceptualize structure-function relationships in the human brain, paving the way for an improved understanding of how demyelination and/or EI-imbalances induce reorganization in brain disorders. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Empirical constraints on the turbulence in QSO host nebulae from velocity structure function measurements by Mandy C. Chen et al. on Monday 12 September We present the first empirical constraints on the turbulent velocity field of the diffuse circumgalactic medium around four luminous QSOs at $z!approx!0.5$--1.1. Spatially extended nebulae of $approx!50$--100 physical kpc in diameter centered on the QSOs are revealed in [OII]$lambdalambda,3727,3729$ and/or [OIII]$lambda,5008$ emission lines in integral field spectroscopic observations obtained using MUSE on the VLT. We measure the second- and third-order velocity structure functions (VSFs) over a range of scales, from $lesssim!5$ kpc to $approx!20$--50 kpc, to quantify the turbulent energy transfer between different scales in these nebulae. While no constraints on the energy injection and dissipation scales can be obtained from the current data, we show that robust constraints on the power-law slope of the VSFs can be determined after accounting for the effects of atmospheric seeing, spatial smoothing, and large-scale bulk flows. Out of the four QSO nebulae studied, one exhibits VSFs in spectacular agreement with the Kolmogorov law, expected for isotropic, homogeneous, and incompressible turbulent flows. The other three fields exhibit a shallower decline in the VSFs from large to small scales but with loose constraints, in part due to a limited dynamic range in the spatial scales in seeing-limited data. For the QSO nebula consistent with the Kolmogorov law, we determine a turbulence energy cascade rate of $approx!0.2$ cm$^{2}$ s$^{-3}$. We discuss the implication of the observed VSFs in the context of QSO feeding and feedback in the circumgalactic medium. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2209.04344v1

Empirical constraints on the turbulence in QSO host nebulae from velocity structure function measurements by Mandy C. Chen et al. on Monday 12 September We present the first empirical constraints on the turbulent velocity field of the diffuse circumgalactic medium around four luminous QSOs at $z!approx!0.5$--1.1. Spatially extended nebulae of $approx!50$--100 physical kpc in diameter centered on the QSOs are revealed in [OII]$lambdalambda,3727,3729$ and/or [OIII]$lambda,5008$ emission lines in integral field spectroscopic observations obtained using MUSE on the VLT. We measure the second- and third-order velocity structure functions (VSFs) over a range of scales, from $lesssim!5$ kpc to $approx!20$--50 kpc, to quantify the turbulent energy transfer between different scales in these nebulae. While no constraints on the energy injection and dissipation scales can be obtained from the current data, we show that robust constraints on the power-law slope of the VSFs can be determined after accounting for the effects of atmospheric seeing, spatial smoothing, and large-scale bulk flows. Out of the four QSO nebulae studied, one exhibits VSFs in spectacular agreement with the Kolmogorov law, expected for isotropic, homogeneous, and incompressible turbulent flows. The other three fields exhibit a shallower decline in the VSFs from large to small scales but with loose constraints, in part due to a limited dynamic range in the spatial scales in seeing-limited data. For the QSO nebula consistent with the Kolmogorov law, we determine a turbulence energy cascade rate of $approx!0.2$ cm$^{2}$ s$^{-3}$. We discuss the implication of the observed VSFs in the context of QSO feeding and feedback in the circumgalactic medium. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2209.04344v1

The show begins with a COVID update about the need for a honest debate and discussion in this country instead of censorship and divisiveness. Then, Dr. Prather discusses why proper bloodwork is absolutely vital for everyone on an annual basis. In this episode, we talk about:—Why a CNN Medical Analyst who was previously in favor of lockdowns is now being called "unscientific, unethical, and fat-phobic" for changing her mind.—The potential dangers from Original Antigenic Sin and Immune Imprinting related to the COVID vaccine. And why this may explain the "crazy stuff" that is happening with people's immune systems right now that cannot be explained.—The story you will not believe about how hospitals are using improv theater to deal with vaccine hesitancy.—How blood work reveals both what is wrong with the body and what could possibly go wrong.—Why Dr. Prather often identifies problems in someone's bloodwork when several other doctors said there was nothing wrong. And the difference between Disease Care and the Structure-Function Health Care model Dr. Prather uses when evaluating blood work.—The reason why health care costs would dramatically decrease and patient results would improve if our health care system was based more on the Structure-Function Health Care model instead of Disease Care.—Why The Prather Profile blood test is considered "an executive level" blood test identical to what the President of the United States would get. And why Dr. Prather does MORE lab tests as a Structure-Function doctor than Disease Care doctors.—How The Prather Profile blood panel includes more than 50 different tests that covers anything that could possibly be wrong in the body from A to Z.—How Dr. Prather's training included over 650 hours of training on interpreting blood work, while the average medical doctor only has 15 hours of training in medical school.—Why Dr. Prather looks beyond "the normal" reference ranges on blood work, which actually are not the optimal ranges of where you should be.TheVoiceOfHealthRadio.com

In this episode we will be covering Facebook Live Questions 8/15-8/21/22. For the latest updates visit my blog and be sure to join the free Facebook Group Registered Dietitian Exam Study Group with Dana RD! Grab the free RD Exam Prep Class here. Looking for additional tutoring service? Visit my website!

JOIN THE INSIDER & GET EXCLUSIVE CONTENT! https://www.patreon.com/supplementengineer https://supplementengineer.com Coaching & Business inquiries: thesupplementengineer@gmail.com   Renowned industry veteran, formulator, and ingredient pioneer, Bruce Kneller rejoins the show for a discussion on 3DPump-Breakthrough, Mandatory product listing, and much more! Show Notes Topics discussed during our conversation include: Do you need IRB approval to run a clinical study? New 3DPump Breakthrough research coming Bruce's thoughts on Dick Durbin's Mandatory Product Listing Bill Thoughts on higenamine, hordenine, and the FDA Advisory list What are the actual purpose/definition of dietary supplements? Whey Protein adulteration concerns Is dicaffeine malate actually different from caffeine anhydrous? and MORE Before You Go... If you enjoy this podcast and want to see more content like it, please consider leaving a review!   https://itunes.apple.com/us/podcast/supplement-engineer-podcast/id1447389041?mt=2&ls=1

In this episode we will be covering Facebook Live Questions 4/11/22-4/17/22. For the latest updates visit my blog and be sure to join the free Facebook Group Registered Dietitian Exam Study Group with Dana RD! Grab the free RD Exam Prep Class here. Looking for additional tutoring service? Visit my website!

In honor of Valentine's Day, this week's show focuses on Sexual Health. In this episode, you'll find out:--How often is considered a healthy libido?--Why sex plays a role in your overall health, and how sex affects your immune system.--The reason why newlyweds can actually make each other sick (for up to 4 years!)--Why monogamy is healthier for your immune system.--How sex impacts your hormones and can promote healing and improved brain health.--How men can lower their rate of prostate cancer. (And how a man's angle of erection can reveal a lot about his health).--The natural, non-prescription answers for low libido and erectile dysfunction. (And why men who rely on drugs like Viagra probably have underlying health issues.)--The impact of pornography on low libido and a decrease in sexual health. (Plus, how Structure/Function medicine can help with addiction issues, including pornography.)--The STD that is a major cause of infertility and how a woman's sexual satisfaction improves fertility.www.TheVoiceOfHealthRadio.com

Check out this great word from Gabe Mullins about Righteousness.

We kick off the show, as we have for a while now, with the latest COVID-19 update.  Then, Dr. Prather teaches how you can build up your own immune system to better protect yourself.  In this episode, you'll learn: —Why the FDA's approval this week of the Pfizer COVID-19 vaccine will likely lead to more mandates and requirements to get the vaccine. —How only 1-in-1.7 million children are at risk of dying from COVID-19, but 1-in-9 children are having an adverse event associated with the vaccine. —The good news out of Israel regarding a new medication that results in 90% of severely-ill patients getting out of the hospital within 5 days. —Why building up your own resistance can also help protect others, too. —The lab tests Dr. Prather uses to measure a patient's immune system.  And the difference between reading lab work from a Disease Care perspective versus a Structure-Function perspective. —How a higher "phase angle" (the electromagnetic charge around the cell) makes you more resistant to the virus than a lower phase angle. —The most important nutritional aspect for fighting the COVID-19 virus.  And the vitamin that can cut down negative COVID-19 outcomes by 85%. —The importance of proper lab tests so that you can know exactly what vitamins and minerals you need. —The vitamin that is known as the defense mechanism for the lungs.  And the best and safest way to take it to keep respiratory infections under control. —Why Dr. Prather says that Iodine is just as important as Vitamin D for immune health. www.TheVoiceOfHealthRadio.com    

The Lymph System is the unsung hero of the body, but few of us know much about it. In this episode, you'll find out: --How it was just recently discovered that the Lymph System goes to the brain (after years of medical schools teaching otherwise). --That the Lymph System will back up if we don't have enough movement in our bodies to "pump" it. And why waking up with aches and pains is a sign of your Lymph System backing up. --How all autoimmune diseases start with the Lymph System. And how Fibromyalgia is an autoimmune disease of the Lymphatic System. --The giant lymph nodes of tonsils, adenoids, and the appendix. And why you have a greater chance of colon cancer and colon infections if your appendix is removed. --Why Dr. Prather checks the spleen for soreness to indicate the presence of a virus. And how the spleen will hold the Epstein-Barr virus to combat it. --The role the Lymph System plays in balancing fluid in our bodies and the problems that can occur such as Lymphedema and Lymphadenopathy. --The connection between breast cancer and the Lymph System. And why Dr. Prather is adamantly opposed to underwire bras. --Why Dr. Prather says you "cannot really treat cancer if you are not looking at the Lymphatic System". --The breeding ground of infections (and cancer cells) that occurs when the Lymph System is backed up. --The Structure-Function treatments for the Lymphatic System including: supplements, specific Lymphatic Chiropractic adjustments, specialized Lymphatic massage, Lymphatic exercises to "pump" the system", Diathermy, and lasers. www.TheVoiceOfHealthRadio.com    

In this Podcast, series of Audio Discussion of IGNOU Study Materials of Sociology are presented with main points in a story, it covers the content of the IGNOU Study Material of MSO-001 Sociological Theories and Concepts. These Listen Notes are also helpful in the preparations of UPSC/IAS /Civil Services Examinations and other Competitive Examinations. --- Send in a voice message: https://anchor.fm/dr-sushma-singh/message

In this Podcast, series of Audio Discussion of IGNOU Study Materials of Sociology are presented with main points in a story, it covers the content of the IGNOU Study Material of MSO-001 Sociological Theories and Concepts. These Listen Notes are also helpful in the preparations of UPSC/IAS /Civil Services Examinations and other Competitive Examinations. --- Send in a voice message: https://anchor.fm/dr-sushma-singh/message

In this Podcast, series of Audio Discussion of IGNOU Study Materials of Sociology are presented with main points in a story, it covers the content of the IGNOU Study Material of MSO-001 Sociological Theories and Concepts. These Listen Notes are also helpful in the preparations of UPSC/IAS /Civil Services Examinations and other Competitive Examinations. --- Send in a voice message: https://anchor.fm/dr-sushma-singh/message

In this Podcast, series of Audio Discussion of IGNOU Study Materials of Sociology are presented with main points in a story, it covers the content of the IGNOU Study Material of MSO-001 Sociological Theories and Concepts. These Listen Notes are also helpful in the preparations of UPSC/IAS /Civil Services Examinations and other Competitive Examinations. --- Send in a voice message: https://anchor.fm/dr-sushma-singh/message

In this Podcast, series of Audio Discussion of IGNOU Study Materials of Sociology are presented with main points in a story, it covers the content of the IGNOU Study Material of MSO-001 Sociological Theories and Concepts. These Listen Notes are also helpful in the preparations of UPSC/IAS /Civil Services Examinations and other Competitive Examinations. --- Send in a voice message: https://anchor.fm/dr-sushma-singh/message

COVID-19 Long Haulers are patients who continue to have symptoms past 4-6 weeks.  Dr. Prather says that using a Structure-Function approach to their care has been "100% successful".  In this episode, you'll discover: —How even those with mild cases of COVID-19 are showing up with Long Hauler symptoms. —How COVID-19 Long Haulers are mostly young women between the ages of 15 and 45. —The connection between COVID-19 Long Haulers and patients who previously had Auto-Immune Disease and Epstein-Barr Virus. —The symptoms of COVID-19 Long Haulers, including Myalgic Encephalomyelitis (formerly Chronic Fatigue Syndrome), Fatigue, and being sore all over. —The Medical treatments being given for COVID-19 Long Haulers, including anti-depressants, anti-anxiety medications, and Beta Blockers.  And why the CDC says that this approach is not working. —Why Dr. Prather tells COVID-19 Long Haulers to avoid being near their smart phone, computer activity, and all Electro-Magnetic energy. —How the lab tests in these patients actually look good, except on one special test that most physicians do not run (but Dr. Prather does). —Why Dr. Prather calls Acupuncture "the key" for the treatment of these patients. —The spinal change pattern associated with COVID-19 Long Haulers  that has been identified by the CDC and "consistently" observed in patients coming into Dr. Prather's office. —Why Homeopathy is "especially helpful" for COVID-19 Long Haulers to see "immediate changes". www.TheVoiceOfHealthRadio.com

Dr. Prather opens the show with a bombshell COVID-19 update about the evidence showing the true origins of the virus.  Then, he talks about how there is hope for Dementia, which affects about 10% of those over the age of 65 and at least 50% of those over the age of 85.  In this episode, you'll learn: --The difference between dementia and Alzheimer's Disease. --How Alzheimer's Disease is increasing and is now the sixth-leading cause of death in America. --The risk factors for dementia, such as: family history, drugs use (both pharmaceutical and recreational), alcohol use, smoking, diabetes, poor nutrition, and cardiovascular disease. --Why medications are often a cause of dementia symptoms, especially cholesterol medications. --How the Structure-Function approach to Health Care focuses on getting the body into homeostasis and should be 80% of our health care. Plus, how Structure-Function Care is more reliant on diagnostics than Disease Care. --Why Dr. Prather says dementia symptoms are usually a multi-faceted process and not just a singular cause. --The importance of Hair Analysis to discover heavy metal toxicities in dementia patients. --The connection between hormones and dementia. And the relationship between inflammation in the body and dementia symptoms. --Why Chiropractic can produce "great results" for dementia patients and can make a person's thinking clearer. --How Acupuncture has been found by the World Health Organization to help with Alzheimer's Disease and dementia. And the connection between depression and dementia. www.TheVoiceOfHealthRadio.com

In today's episode, Brandon Hatchett and Emily Ager are returning to do a podcast with Dr. Lingyan Kong, who is an assistant professor at the University of Alabama. Dr. Kong's focuses on food science through interdisciplinary research. He will discuss his path into food science research, and his work with students here at UA. Dr. Kong's research group hopes to understand the structure-function relationships in food biopolymers at the molecular, microscopic and macroscopic levels, and to develop food materials of unique structures and properties for improving food quality and nutritional benefits. His research group values interdisciplinary and collaborative research projects that integrate knowledge from food science, nutrition, physical chemistry, and materials science. Their in-depth inquiry in the field of food science and nutrition should ultimately aim at finding solutions for a safe, nutritious, and affordable food supply that enhances quality of life and human health.For more information about Dr. Kong's research, check out his website at: https://lkong.people.ua.edu/research.html.

On the show today, I have Patrick Estes, Co-Founder of Evolve Health & Performance, a collaborative effort between Aaron Davis and Patrick Estes to bring services (human performance, fitness, rehab, nutrition, and health management) commonly seen at Olympic training centers to the community of Austin, TX. Patrick served as a strength and conditioning coach at several universities, including the University of Texas at Austin, the University of Denver and the University of Maryland. We discuss the light bulb moments Patrick has experienced in his progression into exercise science, particularly with regard to structure, function, and bioenergetics. We spend a good chunk of our conversation on the underrated importance of breathing for better performance. Patrick shares why a good breather is going to be able to put more miles on their car and what it means to “let your breathing dictate your movement.” He also explains why coaches should focus on helping their athletes recover faster, rather than simply performing better. What You’ll Learn in This Episode: [00:44] An introduction to Patrick [05:45] Light bulb moments for Patrick as he dove into the structure, function, bioenergetics realm [16:15] Replenishing and increasing ATP reserves, and the importance of breathing for better performance [23:36] How MMA fighters can benefit from mastering their breathing [28:15] How your respiratory system can limit your performance [38:25] How CrossFit athletes can up their game by letting their breathing dictate their movement [43:47] Why technology can never replace coaches Links: Explore Evolve Health & Performance here: https://www.evolvehp.life/ (https://www.evolvehp.life/) Follow Patrick Estes on Instagram here: https://www.instagram.com/petrainingsolutions/?hl=en (https://www.instagram.com/petrainingsolutions/?hl=en) Rebel Performance: Text REBELRADIO to 81493 to get 10% off your first program Text RPCOACHING to 81493 to join our next case study training group https://jamescerbie.typeform.com/to/hECiC0hX (Take the Rebel Performance Training Quiz to find the right program for you) https://www.rebel-performance.com/inner-circle-training-team?utm_source=podcast&utm_medium=show%20notes&utm_campaign=coaching (Get a coach that's dedicated to your success) https://www.rebel-performance.com/courses?utm_source=podcast&utm_medium=show%20notes&utm_campaign=course (Take a course to become a better coach)

6 million Americans suffer from Congestive Heart Failure, which is the #1 reason for hospitalization for those over 65. More people are coming down with Congestive Heart Failure than ever before, costing us $100 billion a year. In this episode, learn: --The causes and risk factors of Congestive Heart Failure. --Signs and symptoms of Congestive Heart Failure. --Why Dr, Prather considers Congestive Heart Failure a disease of rich nations and a lifestyle disease that is "completely unnecessary". --How certain pharmaceuticals--like cholesterol drugs--can actually kick off Congestive Heart Failure. --Why disease care can slow down Congestive Heart Failure, but never reverse it. (And why you need Structure/Function health care to reverse Congestive Heart Failure.) --How Dr. Prather approaches Congestive Heart Failure in his patients. --Why Dr. Prather says the heart is the "most easily fixed organ in the body with the highest capacity of regenerating itself". --The machine Dr. Prather uses to help his patients achieve the benefits of aerobic exercise...without the patients actually having to exercise. --Why patients can have hope to reverse their Congestive Heart Failure even though there aren't any good medical options available. --The preventive measures to avoid Congestive Heart Failure, and the tests you should have done to diagnose heart health. www.TheVoiceOfHealthRadio.com  

Structural lipids, signaling lipids, and energy storage --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

We continue our series, "New Year, New You", by talking about the Essential Diagnostics you must have in order to get a blueprint to your health.  And Dr. Prather provides a COVID-19 update.  In this episode, you'll learn: —Why the CDC is advising people with allergic reactions to bring their EpiPen with them when they get the COVID-19 vaccine. —How there are new mutations of the  COVID-19 virus called the United Kingdom and South Africa mutations. —That the U.K. mutation is thought to be more contagious (but not more deadly) and the new COVID-19 vaccine is not expected to be effective with the South African mutation. —Why a Structure-Function practice (like Dr. Prather's office) is actually MORE dependent on lab tests and diagnostics than the Disease Care model. —The three diagnostics Dr. Prather recommends that everyone (even babies)have at least once per year. —How The Prather Profile Blood Analysis checks every organ system in the body. —Why pharmaceuticals do NOT bring your body into homeostasis (the definition of health), but are designed to deal with a person's symptoms. —How Structure-Function Care interprets blood work differently than Disease Care.  And how Dr. Prather has to re-train Medical Doctors and Nurses in his office to analyze blood tests. —The reason you should get a Hair Analysis every year to get a picture of the mineral levels and heavy metal toxicities in your body. —The importance of a G.I. Stool Kit every year because the health of your gut is "the biggest Influence on your immune system" than anything in your body.  And how an estimated 80% of all auto-immune diseases come from the gut. www.TheVoiceOfHealthRadio.com  

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.14.338947v1?rss=1 Authors: Tavakol, S., Li, Q., Royer, J., Vos de Wael, R., Lariviere, S., Lowe, A., Paquola, C., Jefferies, E., Hartley, T., Bernasconi, A., Bernasconi, N., Smallwood, J., Bohbot, V., Caciagli, L., Bernhardt, B. Abstract: Prior research has shown that structures of the mesiotemporal lobe, particularly the hippocampal-parahippocampal complex, are engaged in different forms of spatial cognition. Here, we developed a new paradigm, the Conformational Shift Spatial task (CSST), which examines the ability to encode and retrieve spatial relations between three unrelated items. This task is short, uses symbolic cues, and incorporates two difficulty levels and can be administered inside and outside the scanner. A cohort of 48 healthy young adults underwent the CSST, together with a set of validated behavioral measures and multimodal magnetic resonance imaging (MRI). Interindividual differences in CSST performance correlated with scores on an established spatial memory paradigm, but neither with episodic memory nor pattern separation performance, highlighting the specificity of the new measure. Analyzing high resolution structural MRI data, individuals with better spatial memory showed thicker medial as well as lateral temporal cortices. Functional relevance of these findings was supported by task-based functional MRI analysis in the same participants and ad hoc meta-analysis. Exploratory resting-state functional MRI analyses centered on clusters of morphological effects revealed additional modulation of intrinsic network integration, particularly between lateral and medial temporal structures. Our work presents a novel spatial memory paradigm and supports an integrated structure-function substrate in the human temporal lobe. Task paradigms are programmed in python and made open access. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.25.313528v1?rss=1 Authors: De Zitter, E., Hugelier, S., Duwe, S., Vandenberg, W., Tebo, A. G., Van Meervelt, L., Dedecker, P. Abstract: Photochromic fluorescent proteins have become versatile tools in the life sciences, though our understanding of their structure-function relation is limited. Starting from a single scaffold, we have developed a range of 27 photochromic fluorescent proteins that cover a broad range of spectroscopic properties, yet differ only in one or two mutations. We also determined 43 different crystal structures of these mutants. Correlation and principal component analysis of the spectroscopic and structural properties confirmed the complex relationship between structure and spectroscopy, suggesting that the observed variability does not arise from a limited number of mechanisms, but also allowed us to identify consistent trends and to relate these to the spatial organization around the chromophore. We find that particular changes in spectroscopic properties can come about through multiple different underlying mechanisms, of which the polarity of the chromophore environment and hydrogen bonding of the chromophore are key modulators. Furthermore, some spectroscopic parameters, such as the photochromism, appear to be largely determined by a single or a few structural properties, while other parameters, such as the absorption maximum, do not allow a clear identification of a single cause. We also highlight the role of water molecules close to the chromophore in influencing photochromism. We anticipate that our dataset can open opportunities for the development and evaluation of new and existing protein engineering methods. Copy rights belong to original authors. Visit the link for more info

Welcome back. Here's Chapter 2, so get ready to hear the words "potential", "ion channel" and "potassium" repeated a great many times. If you think you would benefit from a rap song like this for all of the chapters, please send me an email at abstractcast@gmail.com so I can gauge interest. If I hear from enough of you then I will gladly write the rest, however, if this doesn't appeal to a large enough audience, then I may have to scrap the project. The first few chapters of Rapstract are already written and will be released here on my podcast page, Abstract. I interview graduate students on their research, many of whom are studying psychology. I urge you to peruse and have a listen to the first episode that catches your eye! /// If you like what you hear, please feel free to check out my latest rap album called Life As We Know It at any of the following links: YouTube SoundCloud Bandcamp Chapter 2 was produced by: Beat: High End [Prod.kanebeats x Heartboy] Lyrics, Vocals, Recording: Pcenna --- Send in a voice message: https://anchor.fm/abstractcast/message

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.10.244616v1?rss=1 Authors: Bryant, J. A., Morris, F., Knowles, T. J., Maderbocus, R., Heinz, E., Boelter, G., Alodaini, D., Colyer, A., wotherspoon, P., Staunton, K., Jeeves, M., Browning, D., Sevastsyanovich, Y., Wells, T., Rossiter, A., Bavro, V., Sridhar, P., Ward, D., Chong, Z.-S., Icke, C., Teo, A., Chng, S. S., Roper, D., Lithgow, T. J., Cunningham, A. F., Banzhaf, M., Overduin, M., henderson, i. Abstract: The Gram-negative outer membrane envelops the bacterium and functions as a permeability barrier against antibiotics, detergents and environmental stresses. Some virulence factors serve to maintain the integrity of the outer membrane, including DolP (formerly YraP) a protein of unresolved structure and function. Here we reveal DolP is a lipoprotein functionally conserved among Gram-negative bacteria and that loss of DolP increases membrane fluidity. We present the NMR solution structure for DolP, which is composed of two BON domains that form an interconnected opposing pair. The C-terminal BON domain binds to anionic phospholipids through an extensive membrane:protein interface providing evidence of subcellular localization of these phospholipids within the outer membrane. This interaction is essential for DolP function and is required for sub-cellular localization of the protein to the cell division site. The structure of DolP provides a new target for developing therapies that disrupt the integrity of the bacterial cell envelope. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.28.225631v1?rss=1 Authors: Silva, G. A., Muotri, A. R., White, C. Abstract: A basic neurobiology-clinical trial paradigm motivates our use of constrained mathematical models and analysis of personalized human-derived brain organoids toward predicting clinical outcomes and safely developing new therapeutics. Physical constraints imposed on the brain can guide the analyses an interpretation of experimental data and the construction of mathematical models that attempt to make sense of how the brain works and how cognitive functions emerge. Development of these mathematical models for human-derived brain organoids offer an opportunity for testing new hypotheses about the human brain. When it comes to testing ideas about the brain that require a careful balance between experimental accessibility, manipulation, and complexity, in order to connect neurobiological details with higher level cognitive properties and clinical considerations, we argue that fundamental structure-function constraints applied to models of brain organoids offer a path forward. Moreover, we show these constraints appear in canonical and novel math models of neural activity and learning, and we make the case that constraint-based modeling and use of representations can bridge to machine learning for powerful mutual benefit. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.29.118737v1?rss=1 Authors: Andersson, M., Kjer, H. M., Rafael-Patino, J., Pacureanu, A., Pakkenberg, B., Thiran, J.-P., Ptito, M., Bech, M., Bjorholm Dahl, A., Andersen Dahl, V., Dyrby, T. B. Abstract: Axonal conduction velocity, which ensures efficient function of the brain network, is related to axon diameter. Non-invasive, in vivo axon diameter estimates can be made with diffusion magnetic resonance imaging, but the technique requires 3D validation. Here, high resolution, 3D synchrotron X-ray Nano-Holotomography images of white matter samples from the corpus callosum of a monkey brain reveal that blood vessels, cells and vacuoles affect axonal diameter and trajectory. Within single axons, we find that the variance in diameter and conduction velocity correlates with the mean diameter, contesting the value of precise diameter determination in larger axons. These complex 3D axon morphologies drive previously reported 2D trends in axon diameter and g-ratio. Furthermore, we find that these morphologies bias the estimates of axon diameter with diffusion magnetic resonance imaging and, ultimately, impact the investigation and formulation of the axon structure-function relationship. Copy rights belong to original authors. Visit the link for more info

How to make claims dietary supplement claims (without getting slapped by the FDA) We'll cover some of the different types of claims as well as how to properly make a Structure / Function claim.Brought to you by http://www.creativethirst.com The revenue optimization agency for health supplement companies. Specializing in split tests, funnels, upsells, and direct response copywriting so you can maximize profitability and scale.

Musculoskeletal issues are the bread and butter of many acupuncture practices. Many people only think of acupuncture when they think about the treatment of pain, and not without good reason. Acupuncture is helpful in the treatment of pain. And as acupuncturists we know we could probably do a lot better too. In this conversation we explore the use of the Dao Zhen, the knife needle. But more importantly, we take a look at how the body is put together. And how to “see” the story of a person’s physiology.  Listen in for a conversation about understanding structure and function and a surprising method of needling.   Head on over to the show notes page for more information about this episode and for links to the resources discussed in the interview.