Podcasts about IRB

On this episode, we spoke with Bob Radocy, founder of Fillauer TRS, and Debra Latour, OTD, M. Ed., OTR/L, Doctoral Experiential Capstone Coordinator at Western New England University, about activity-specific prostheses and how they can support patients both physically and emotionally.  Learn more about Bob and Debra and access Empowering People, Empowering Prosthetics. Discover Fillauer TRS.  Many thanks to Thuasne for sponsoring this episode! Introducing the newest member of the SpryStep line, the SpryStep One. An elegant, durable, effective, and universal AFO made with a precise selection and layup of diverse composite materials. The SpryStep One meets the individual needs of your patient with only two SKUs.  SPS is thrilled to introduce the Bionic Power Agilik smart orthosis, the first powered microprocessor-controlled knee-ankle-foot orthosis designed for adult and pediatric patients with neurological and musculoskeletal gait impairments affecting mobility and function. Backed by an IRB-approved clinical study and published outcomes, the Agilik boosts endurance and mobility with smart, real-time knee extension and flexion.  Tune into the latest episode of The Clinical Minute where SPS Clinical Education Specialist DeLana Finney, MSPO, LCPO, provides a quick overview of the cutting-edge Fillauer FastPro flexible alignment system.  Visit spsco.comAlso, email us! The O&P Check-in is a bi-monthly podcast featuring the latest orthotics and prosthetics news, trends, best practices, regulations and policies. Designed for O&P professionals, join Brendan Erickson and a rotating co-host as they interview guests and share the latest advancements in the industry.

Why are women hitting perimenopause earlier than ever, and what can you do about it?In this episode, Angela sits down with functional nutritionist and hormone pioneer Alisa Vitti, founder of FLO Living and author of WomanCode and In the FLO, to explore the real reasons modern women are struggling with hormonal balance. You'll learn how stress and poor sleep suppress ovulation, why melatonin is the first hormone to decline in perimenopause, and how to rebuild hormonal resilience through nutrition, strength training, and oxytocin-boosting practices.Alisa also shares her groundbreaking Cycle Syncing® Method, backed by IRB-approved research showing up to 80% symptom reduction in just 30 days. If you want to understand how your hormones, mood, and energy are linked - and how to extend your hormonal youth - this episode is essential. What You'll Learn: • Why stress accelerates hormonal aging and earlier perimenopause • How ovulation acts as a “deposit” into your longevity bank account • Cycle Syncing®: IRB-backed results showing 80% fewer symptoms in 30 days • The midlife nutrition and training blueprint for women • Why oxytocin and nitric oxide are critical for mood, metabolism, and muscle • The hidden downsides of methylene blue and antibacterial mouthwash • Sauna vs. cold therapy: what really benefits women's hormones • How Alisa built FLO Living as a longevity-focused women's health platform • Alisa's daily non-negotiables for hormonal balance Timestamps: 00:00 Intro 01:32 The Stress Epidemic & Earlier Perimenopause 04:40 Ovulation, Cortisol & the Infradian Rhythm 06:06 Cycle Syncing® Clinical Trial: 80% Symptom Reduction 08:42 Why Ovulation = Longevity Deposits 12:28 The First Hormone to Decline: Melatonin 14:34 Midlife Nutrition Shifts: Protein, Carbs & Alcohol 16:00 Strength Training & Midlife Body Composition 28:17 Alisa's Travel Meal-Prep Routine 32:52 Restaurant Pitfalls: Seed Oils, Sodium & Smart Ordering 35:24 Macro Targets: Protein per Meal, Carbs per Day 37:23 Carb Timing for Sleep & HRV 40:38 Oxytocin, Nitric Oxide & Edging Explained 40:52 The Methylene Blue & Mouthwash Mistake 50:37 Cold Exposure vs Sauna for Women 54:42 Building FLO Living & Avoiding Burnout 59:08 Alisa's Non-Negotiables: Food, Movement, Sleep 1:00:27 Where to Find Alisa & FLO Living VALUABLE RESOURCES A BIG thank you to our sponsors who make the show possible: • Carol Bike - Exclusive discount for podcast listeners on Carol Bike - the bike that gets you fittest the fastest - click here http://www.carolbike.com/⁠⁠ and use code ANGELA • Supercharge your energy and upgrade your mitochondria with Mitopure - http://timeline.com/angela | Enter code ANGELA to save 10% ABOUT THE GUEST Alisa Vitti is the founder and CEO of FLO Living and creator of the Cycle SyncingⓇ Method. A leading women's hormone and biohacking expert, she discovered the Infradian Rhythm and authored the bestsellers WomanCode and In the FLO, empowering women to live in sync with their biology.

Have you ever felt the soul of your workplace—the sense of connection, purpose, and community—start to fade? That's exactly what happened to Dr. Sonia Millan, a board-certified family medicine physician with additional certifications in sports and lifestyle medicine. When her autonomy dwindled and joy disappeared, she knew it was time to make a change. Instead of leaping into the unknown with one perfect plan, Sonia earned what she calls her "honorary master's in pivotry." She experimented, explored, and stayed curious—trying everything from chart review and patient advocacy to IRB work and prison-system audits. Some paths fit, others didn't, but each step brought her closer to a career she truly loves. And here's the twist: the job she once thought she'd never enjoy is now her 10-out-of-10 dream role. Her journey is a powerful reminder that clarity doesn't come from waiting for the perfect plan—it comes from moving, experimenting, and letting go of what's not for you. In this episode we're talking about: How losing autonomy in clinical practice led Sonia to explore new possibilities The mindset shift that helped her turn uncertainty into opportunity Unexpected lessons she learned from eight years as a white-water rafting guide How she tested different nonclinical paths (and what she learned from each one) What changed her mind about her current role and why she now loves it How curiosity, intuition, and her "lunch litmus test" helped her find her ideal fit The spiritual practice that keeps her grounded. Links for this episode:

If you’ve ever wondered what the difference is between a Switched Virtual Interface (SVI) and Integrated Routing and Bridging (IRB), today’s show is for you! Ethan Banks and Holly Metlitzky start with some history and the basics of communication between layer 2 and layer 3 and then explain how the concepts of SVI and IRB... Read more »

If you’ve ever wondered what the difference is between a Switched Virtual Interface (SVI) and Integrated Routing and Bridging (IRB), today’s show is for you! Ethan Banks and Holly Metlitzky start with some history and the basics of communication between layer 2 and layer 3 and then explain how the concepts of SVI and IRB... Read more »

Il Premio Nobel per medicina e fisiologia di quest'anno ci ha fatto scoprire come lavorano e come a volte si confondono i linfociti T Citotossici provocando malattie autoimmuni. L' ospite odierno di Millevoci Scienza e Ricerca ci aiuterà a capire come lavorano i Linfociti T per l'eliminazione delle cellule tumorali e come lavorano i linfociti T a protezione del nostro sistema immunitario, con relative applicazioni cliniche già impiegate. Lei è Greta Guarda Direttrice del Laboratorio di Meccanismi del Sistema Immunitario dell'Istituto di ricerca in biomedicina (IRB) affiliato all'USI, e Professoressa ordinaria presso la Facoltà di scienze biomedicheLa Seconda pagina della puntata è dedicata alla Tecnologia con le Prove di Paolo che ci proietteranno dentro la centralina del nuovo Notebook LM

Trân Lê, Co-Founder and CEO of Grove AI,  was founded to automate the manual and inefficient workflows in clinical trial recruitment, patient engagement, and support. The company's AI agent, Grace, is trained on specific trial protocols and approved scripts to respond to patient questions about pre-screening, logistics, and scheduling appointments. This platform aims to increase speed and quality of participant recruitment, improve representation, and expand accessibility to clinical trials by offering support in over 19 languages and providing access to information on demand. Trân explains, "The birth of Grove really came from my co-founder, Sohit, and his experience working in the hospital. We were working at Stanford, and there we were, computer scientists building a lot of internal tools for clinical trials, clinical research, as well as for the greater healthcare patient services. And that, combined with my experience trying to enroll in a clinical trial, really set us off to think deeply about how we can automate a lot of the manual workflows that exist today for patients and for providers, as well as for pharma in taking new drugs to market. Specifically, within that, we identified patient engagement and support, and prescreening to be an important part of ensuring that patients know where they're going and what to do when they're participating in these trials. And so we decided to really step out into the industry and change this process and make it an easier and more accessible experience for patients."   "I would say that having worked inside a hospital and seeing all of this lead generation or getting people educated about the trial is an important aspect, and it's being done by a lot of the recruitment vendors as well as in-house teams out there. In addition to that, a bottleneck that previously has always been there now is possible to automate with agentic AI is actually doing the work of taking all the interest from different potential patients and helping them prescreen and understand the requirements of the trials, getting them to the right site, booking their transportation, reminding them about the appointments, and scheduling that appointment."   "I would say that Grace, as we call her, is a digital staff or an AI agent - both are comparable terms to describe Grace. The difference is that Grace is trained on the trial, the requirements, and the IRB-approved script of that trial. So she really has the knowledge to be able to respond spontaneously in real time to any questions that the participant may have about the trial." #GroveAI #ClinicalTrials #PatientRecruitment #Pharma #HealthTech #DigitalHealth #AI #AgenticAI grovetrials.com Listen to the podcast here

Trân Lê, Co-Founder and CEO of Grove AI,  was founded to automate the manual and inefficient workflows in clinical trial recruitment, patient engagement, and support. The company's AI agent, Grace, is trained on specific trial protocols and approved scripts to respond to patient questions about pre-screening, logistics, and scheduling appointments. This platform aims to increase speed and quality of participant recruitment, improve representation, and expand accessibility to clinical trials by offering support in over 19 languages and providing access to information on demand. Trân explains, "The birth of Grove really came from my co-founder, Sohit, and his experience working in the hospital. We were working at Stanford, and there we were, computer scientists building a lot of internal tools for clinical trials, clinical research, as well as for the greater healthcare patient services. And that, combined with my experience trying to enroll in a clinical trial, really set us off to think deeply about how we can automate a lot of the manual workflows that exist today for patients and for providers, as well as for pharma in taking new drugs to market. Specifically, within that, we identified patient engagement and support, and prescreening to be an important part of ensuring that patients know where they're going and what to do when they're participating in these trials. And so we decided to really step out into the industry and change this process and make it an easier and more accessible experience for patients."   "I would say that having worked inside a hospital and seeing all of this lead generation or getting people educated about the trial is an important aspect, and it's being done by a lot of the recruitment vendors as well as in-house teams out there. In addition to that, a bottleneck that previously has always been there now is possible to automate with agentic AI is actually doing the work of taking all the interest from different potential patients and helping them prescreen and understand the requirements of the trials, getting them to the right site, booking their transportation, reminding them about the appointments, and scheduling that appointment."   "I would say that Grace, as we call her, is a digital staff or an AI agent - both are comparable terms to describe Grace. The difference is that Grace is trained on the trial, the requirements, and the IRB-approved script of that trial. So she really has the knowledge to be able to respond spontaneously in real time to any questions that the participant may have about the trial." #GroveAI #ClinicalTrials #PatientRecruitment #Pharma #HealthTech #DigitalHealth #AI #AgenticAI grovetrials.com Download the transcript here

Other Episodes You Might Like: Previous Episode - The Exercise Crisis Destroying Women's Metabolisms (And How to Fix It with Just 2 Workouts) Next Episode - What's Too Late for Bone Density More Like This - Acute vs Chronic Stress Effects on Cortisol in Menopause and Beyond Resources: Stress Nation book by Justin Hai reveals how cortisol — the misunderstood Master Hormone — is at the center of it all. Join the Hot, Not Bothered! Challenge to learn why timing matters and why what works for others is not working for you. Understand how sleep relates to your hormones, muscle mass and weight loss with Flipping 50 Sleep Yourself Strong. Cortisol is truly the missing link in the conversation about wellness, health, fitness, fatness, sleeplessness, and the optimal body composition We're going to take a look at how cortisol follows a natural rhythm, and what light exposure, movement, and food timing have to do with getting your energy and focus back. We'll talk about why most health trends are focused on sleep and hormones, especially in menopause. If you're struggling about cortisol or want the science-backed information, this episode is for you. Know why cortisol is the missing link. My Guest: Justin Hai is the co-founder of several award-winning wellness companies, including Alastin Skincare (acquired by Galderma), GLO Pharmaceuticals, and Rebalance Health. With a background in industrial design and an MBA from Pepperdine, Justin blends creative vision with real science—holding multiple U.S. patents and has presented to NASA and the Pentagon. He is also a featured expert in the upcoming Amazon Prime documentary sHEALed and a passionate advocate for redefining wellness through the lens of hormonal balance, sleep science, and stress mastery. Questions We Answer in This Episode: 06:00- How did you get so deeply interested in studying cortisol? 07:36 - Why is cortisol high in 2025? 12:17 - What is the value of the double blind IRB (independent review board) studies? 14:24 - What's changed in the last 30 years that's spiking our cortisol now?  23:43 - Tell us about Cushing's. 27:23 - How does social media affect hormones? 30:59 - What are the rebalanced lozenges and how do they work? 34:13 - What's the difference between menopause and adropause?

Abra sua conta na Binance e se junte aos outros 280 milhões de usuários agora mesmo: https://binance.onelink.me/y874/MarketMakerNeste episódio 268 do Market Makers, Thiago Salomão e Matheus Soares recebem Marcos Falcão, o CEO que está liderando uma das maiores e mais impressionantes reviravoltas da bolsa brasileira: a do IRB(Re). Marcos Falcão, um veterano do mercado financeiro que construiu sua carreira no Icatu, conta como assumiu a presidência da resseguradora "por acidente" e revela como sua mentalidade de mercado financeiro está transformando o tradicional mundo dos seguros.Ele detalha o cenário de terra arrasada que encontrou na companhia, abalada por uma fraude contábil, seguida pela pandemia e uma seca histórica que impactou fortemente o agronegócio. Falcão expõe os bastidores da recuperação, um processo que envolveu dois aumentos de capital, uma limpeza completa na carteira de riscos internacionais, a revisão de todos os processos e, principalmente, a recuperação da moral de um time que, segundo ele, foi o verdadeiro responsável por manter a empresa de pé. Descubra como o IRB saiu de uma crise de credibilidade para apresentar resultados positivos, voltar a pagar dividendos e traçar um ambicioso "Plano 2030" para crescer. Além disso, Falcão aborda a enorme desvantagem de competir com resseguradoras em paraísos fiscais enquanto paga 45% de imposto no Brasil e fala sobre seus planos para fortalecer a companhia antes de sua aposentadoria compulsória aos 65 anos.Depois de ouvir a história completa, qual a sua opinião: você acredita no futuro do IRB (IRBR3) e tem ou teria as ações na sua carteira? Comente aqui embaixo!

OSFI has finalized revisions to the CAR guideline, effective Q1 2026, which significantly impacts how banks treat mortgages tied to rental income. The key change prevents borrowers from reusing the same income to qualify for multiple properties, which will make it harder for small investors to grow their portfolios. The 50% borrower-income test is reaffirmed, but now income used for one mortgage cannot be used again for another property. This could reduce mortgage qualifying amounts from around $700,000 to $300,000 for typical investors. B-side lenders (credit unions, private mortgage companies) not bound by OSFI regulations can fill the gap by continuing to consider global income, though typically at 1-3% higher interest rates. Combined loan products will be treated as a single risk, new IRB banks must start with high capital floors, and a new Credit Risk Management guideline is coming in January 2026. LIVE PODCAST TICKETS Exchange-Traded Funds (ETFs) | BMO Global Asset Management Buy & sell real estate with Ai at Valery.ca Get a mortgage pre-approval with Owl Mortgage LISTEN AD FREE free 1 week trial for Realist PremiumSee omnystudio.com/listener for privacy information.

Bio: Jenny - Co-Host Podcast (er):I am Jenny! (She/Her) MACP, LMHCI am a Licensed Mental Health Counselor, Somatic Experiencing® Practitioner, Certified Yoga Teacher, and an Approved Supervisor in the state of Washington.I have spent over a decade researching the ways in which the body can heal from trauma through movement and connection. I have come to see that our bodies know what they need. By approaching our body with curiosity we can begin to listen to the innate wisdom our body has to teach us. And that is where the magic happens!I was raised within fundamentalist Christianity. I have been, and am still on my own journey of healing from religious trauma and religious sexual shame (as well as consistently engaging my entanglement with white saviorism). I am a white, straight, able-bodied, cis woman. I recognize the power and privilege this affords me socially, and I am committed to understanding my bias' and privilege in the work that I do. I am LGBTQIA+ affirming and actively engage critical race theory and consultation to see a better way forward that honors all bodies of various sizes, races, ability, religion, gender, and sexuality.I am immensely grateful for the teachers, healers, therapists, and friends (and of course my husband and dog!) for the healing I have been offered. I strive to pay it forward with my clients and students. Few things make me happier than seeing people live freely in their bodies from the inside out!Danielle (00:28):Welcome to the Arise Podcast, conversations based in what our reality is, faith, race, justice, gender in the church, therapy, all matter of things considered just exploring this topic of reality. Hey, I'm having this regular podcast co-host. Her name is Jenny McGrath. She's an M-A-C-P-L-M-H-C. She's dope. She's a licensed mental health counselor, a somatic experiencing practitioner, certified yoga teacher, and an approved supervisor in the state of Washington. She spent over a decade researching the ways in which the body can heal from trauma through movement and connection. And she's come to see that bodies are so important and she believes that by approaching the body with curiosity, we can begin to listen to the innate wisdom our body has to teach us. And that is where the magic happens. So I hope you're as thrilled as me to have such an amazing co-host join me. Yeah, we're going to talk about reality and therapy. We're just jumping in. Jenny and I are both writing books.Jenny, I think it's funny that we are good friends and we see each other when we're around each other, but then if not, we're always trading reels and often they're like parodies on real life. Funny things about real life that are happening, which I've been, the theme of my book is called Splitting, and I know you write about purity culture, and a part of that I think really has to do with what is our reality and how is it formed? And then that shapes what we do, how we act, how we behave in the world, how we relate to each other. So any thoughts on that? On Thursday, September 25th,Jenny (02:17):I mean, as you named that, I think 10 minutes before this started, I sent you a reel. There was a comedian singing Why She Doesn't Go to Therapy, and it says, all my friends that go to therapy are mean to me, and you don't have boundaries. You're just being an asshole. And it was good, but it was also existential. This was what seems to me a white woman. And I do think as a white woman who's a therapist, I feel existential a lot about the work I do in therapy and in healing spaces, and how we do this in a way that doesn't promote this hyper individualistic reality. And this idea that everything I see and everything I think is the way that it is, how do I stay open to more of a communal or collective way of knowing? And I think that that's a challenging thing. So that's something that comes to mind for me as you bring up Instagram reels.Danielle (03:26):Oh man, I have so many thoughts on that that I wasn't thinking before you said it, but I think they were all locked in a vault, been unleashed. No, seriously. You come from your own position in the world. Talk about your position and how did you come to that point of seeing more of a collective mindset or reality point of view?Jenny (03:47):I mean, honestly, I think a big part has been knowing you and working with you and knowing that I think we've had conversations over the years of both the privilege and the detriment that happens in a lot of white therapeutic spaces that say you just need detach from your family, from your community, from those who have harmed you. And I want to be very, very clear and very careful that obviously I do think that there are situations we need to extract ourselves from and remove ourselves from. And I think that can become disabling for bodies to, I've been having this thing play in my head lately where I'm like, are you healed? Or have you just cut off everyone that triggers you?Yeah, and I saw another, speaking of meme, it was like, I treat my trauma like Trump treats tariffs. I just implement boundaries arbitrarily, and they harm everyone.And so I think it's, there is a certain privilege that comes with being able to say, I'm just going to step away. I'm going to do my own thing. I'm going to do my healing journey. And I think there is a detriment to that and there's a loss. And I think we have co-evolved to be in community and to tell stories and to share reality and to hold reality in the tension of our space. I think about it as we each have a different lens. There's no objective reality, but if I can be open to your lens and you can be open to my lens, then we actually have two lenses, and then if we have five lenses or 10 lenses, we can have a much fuller picture of where we are rather than seeing the world through the really monochromatic white, patriarchal, Christian nationalist lens that we've been maybe conditioned, or at least I was conditioned to see the world through.Danielle (06:10):Yeah. Whoa. Yeah, I know we've talked about this so many times, and I think it just feels so present right now, especially as every moment it feels like every day. If you watch the news, if you don't take a break, I think you can be jarred at any moment or dissociated at any moment, or traumatized at any moment, or maybe feel a bit of joy too when someone says a smack down on your side of the issue. And I think that when we get in that mode of constantly being jarred and then we try to come into a healing space, it's like how do we determine then what is actually healing for us? What is actually good? What is actually wise? And I agree, I think if we're in a rhythm of being on our own, and I'm not criticizing, I mean, I get lonely and I'm part of a group, so I'm not speaking to loneliness particularly, but I'm speaking to the idea that no one else has input in your life, even the kind of input you may not agree with, but no one else is allowed to speak to you.(07:15):When I get in those spaces, it's not that I just feel lonely, I don't feel any hope. I don't feel any movement or any possibility because let's say that this ends tomorrow, that authoritarian regime magically ends. It's healed tomorrow. We're going to have to look at all of our people in our lives and face them and decide what we're going to do. I mean, that's what I think about a lot. At the end of the day, I might sit next to someone that hates me or that I perhaps might have rage and anger towards them. What are we going to do? So I don't know, when you talk about the different lenses, I'm not sure how that all mixes together. I don't have an answer, basically. Shoot.Jenny (08:05):But I also think that that's part of maybe how we hold reality is maybe it is more about presence and being with what is, rather than having an answer, I think I become more and more skeptical of anyone who says they have an answer for anything.Danielle (08:31):So I mean, there was this guy that recently passed away, and there was, on one hand I wanted to really talk about it, and on the other hand, I didn't want to talk about it because it took up so much space. And I feel that even as we start to talk about how do we form healing spaces in therapy with that, I think, what did you call it that, what kind of lens did you say? It was like a monochromatic lens. How do we talk about that without centering it?Jenny (09:08):I think one thing that comes to mind is holding it in context of all of the other deaths that have not taken up that space. And the social studies phrase, what are the conditions of possibility that have enabled this death to create church services happening that have taken over people's social media, people who have been silent about lots of different deaths in the last year or five years, all of a sudden can't help but become really vigilant about talking about this. I think for me, it helps to zoom back and go, how come? Why is this so prevalent? Why is this so loud? What is this illuminating or what is this unearthing about? What's already been here?So I grew up in very fundamentalist, white evangelical Christianity. And from the time I was eight, nine years old, I had in me messages instilled of martyrdom, whether that was a message that I should be a martyr, or whether that was a message that Christians were already being martyred, whether that was the war against Christmas with Starbucks cups or not having prayers happen at school. And these things where I grew up in this world where we were supposed to be prominent, we were supposed to be prevalent, we were supposed to be protected. And whenever there was any challenge to that from bodies that weren't white or straight or Christian or American, there became this very real frenzy around martyrdom. And I think on an interpersonal level and on a collective level, someone who plays the victim will always hold the most power in the relational dynamic. And so I think that this moment was a very useful moment to that psyche and that reality of seeing the world as a victim, as a martyr, as being persecuted, regardless of the fact that evangelical Christians are the strongest floating block in our nation. They have incredible privilege when it comes to a lot of education, marriage inequality, things like that, that are from the long lineage of Christian nationalism in our country.Danielle (12:15):So then how do you work with folks that are coming in with that lens, and what's the responsibility of our field? I know you and I can't answer that question necessarily, but we can just say from our own experience what that's like. Are you willing to share a little bit of that?What would I say? My client load is mixed and so do a lot of work, but just because it's mixed doesn't mean that I'm not currently undoing that process in myself as well. So I think just as much as therapy is about whoever comes into my office or shows up in the zoom room or even a group or a teaching we've been a part of, I think it's, well, I mean we say this co-created, but I actually mean it means I have to keep learning. I have to keep trying to be in my body. And what I mean by that is I was talking to my friend Phil yesterday, and he was like, Danielle, are you tracking your body sensations? And he's like, I just challenge you to do that today. And I was like, man, that that's a good reminder. So I think one way I try to come with clients is from the perspective of I don't know it all.(13:38):I only know what I'm feeling and sensing in this moment, and I have that to offer along with other things I've studied, of course. But just because the person sitting with me doesn't have a degree or the group and the people, doesn't mean they don't know just as much as me. It's just another form of maybe learning or knowing or presence and healing. And then we're figuring that out together. I see that as one way of undoing, undoing this. I know everything point of view, which I kind of felt like I had to have when I came out of grad school. Yeah,Jenny (14:14):Yeah, totally. Yeah, I feel similar and I think often think in quotes. And so one of my favorite quotes is by Simone Devo, and she says, without a doubt, it is always more comfortable to endure blind bondage than to work for one's liberation. And so I am consistently asking, where is my blind bondage? Who are the people in my life that will show me where my blind bondage is? Who are the people that will hold me accountable to my own liberation? And for me as a therapist, I work primarily with white folks who grew up in fundamental Christianity. And over 10 years of doing that work, I think that a primary part of my work is radical agency(15:13):Because I think that particularly white bodies maintain privilege by abdicating our agency and by being compliant with the systems that give us power and give us privilege. And so I think for me, my ethic is how do I help clients come into contact with their radical agency? And so a big part of that that I think is important is consent. And so if someone is coming to work with me, it's part of my disclosure form, it's part of my intake to say, I don't think our mental health concerns or our somatic concerns exist in a bubble. They are deeply impacted by the systems we move through. And so while we'll be engaging your individual body, we're also going to be engaging the collective structures. And I've had people say, no, I don't want to do that work. And I say, great, there are other lovely therapists that will work with you and be a better fit. That's just not the type of therapy I do. That's not within my scope of practice to only focus on the individual, because for me, that's unethical.Danielle (16:23):Oh, that's cool. I like that, Jenny. I think that a lot. I was consulting recently, and we're just talking about this current moment, and I'll just say from my point of view that even in my family, I noticed when something had gone on locally, we have some organizing that we do and we had some warnings go out. And I noticed even in my own family, the heightened anxiety, the alert, and one of the things we had to do was we took turns driving around just making sure everybody's safe and everybody was safe. And I came down and at the point where people began to lower anxiety, and we're talking about just regular business owners, regular people out there, we're not even talking about immigrants, quote migrants. We're just talking about people out there that don't want to encounter force. You could feel the anxiety just lower now that we went the parking lot's clear, no one's here, we're safe. This isn't happening, not today. I'm not saying it won't happen here in our area of the country, but it's not happening today. And I realized in consultation later about clients and stuff that things are going to, but the clinician I was consulting with just said to me, she said to me, just for your family, she's like, that anxiety is warranted. That's real. You're supposed to feel anxious. There's no way you can take that away for those people and you shouldn't.(18:02):And so just kind of learning, reminding myself, when you go to grad school, when you study therapy and psychology, there's pathological, there's diagnoses, all these things, but then there's some things like we just can't take away. They're part of the experience. They need to be there. They're part of the warning. And there's a reason why when you get out and do something practical for a community, the anxiety lowers. And I think that just gave me a lot of insight, not just for my client, but for my family and for myself. And there's some calm, not because I'm anxious, but because, oh, I'm not crazy. I'm not just making this up. And so I do think that speaks to how the system is creating trauma and it is powerless. What can we do against the big bad authorities? And we can do things, we can connect, we can be with people, but at some level, that baseline of anxiety is going to be there because it's warranted. That's how I think of it.What do we do? Well, we sat at home, we watched sports. We went to Best Buy, and this is not every, we had some privilege. We bought an extra controller to play Mario World or whatever it was. I don't remember, but I was like, I'm not playing on that little controller. They wanted me to hold. I was like, I need a real controller. I'm old. I need to be able to feel it in my hands. Just silly stuff. Just didn't put pressure on the kids to do homework. Not a pressure to clean the house, just to just exist. Just be, yeah. What about you? What do you do when you encounter either anxiety from trauma like that or the systemic pressure maybe to even conform to whiteness or privilege in that moment?Jenny (20:12):I typically need to move my body in some way, whether that's to take my dog on a very long walk or whether that's just to roll around on a dance floor or maybe do a yoga practice. I become aware of how my body is holding that, and I think about how emotions are just energy in motion. And so if we don't give them motion and expression, it becomes like a battery pack in our nervous system. And so I can feel that if I haven't been able to move and to express whatever my body needs to express, and often I don't even know cognitively what my body needs to express, but I've grown in trust that my body knows, and I say, I think the sillier we look the better it usually feels. I just saw this lovely post the other day, a movement person did where they, we talk a lot about brainwashing, but we don't talk a lot about body washing, and we are so conditioned to only move our body in certain ways. And because our body is not different than our brain, I think that the more free we feel in our actual physical body to our own ability, the more that can actually create a little bit more mobility in how we see reality and how we engage with it.Danielle (21:44):So take that back to the beginning where you started talking about how when you have clients come in, you're like, yo, we're going to address this systemically and collectively. What do you do with folks when they have that kind of energy and you guys are working through it and it's like, oh, it's like maybe that's collective energy. What do you do? Yeah,Jenny (22:02):Yeah. I ask my clients probably annoying amount of times each session, what do you notice right now? And then I follow their body. So if their body says like, oh, I feel a lot of tension in my gut instead of alleviating that, I go, okay, great. Can you actually exaggerate that tension a little bit and see what happens? See if that tension wants to come out in a snarl or a growl, or maybe you want to curl up in a ball and I just follow whatever the impulses of their body are. Or if they say like, oh, I feel a lot in my shoulders. I'm like, great. Do you want to go push against a wall or push against the floor or punch a pillow and let your body actually get some movement into those spaces that you're sensing?Well, as I said, I'm very skeptical about individual work, even though I do it, I don't think is all that. I think it is both necessary and not that helpful for the collective(23:21):Because it is individual. And so I actually do think we need collective spaces of moving and expressing and being in our bodies. I think our ancestors knew this for before Christian supremacy and then white supremacy and then capitalistic supremacy eradicated how we've evolved to move in our and collectively. That being said, I do think that the more we become aware of how our body is constrained and how we've been socialized, especially I think for anybody, but for me, I'll speak to white bodies, we aren't always conscious. We take for granted whiteness and how it affects our bodies. So the first time I'm asking a white person, especially maybe a white woman to look pissed, that's going to be probably really scary because socially we are not actually allowed to be pissed. We're allowed to be dams, souls, and we're allowed to freak out, but we're not actually allowed to be strong and be powerful and be angry. And so I do believe that in that work of individual liberation and freedom, it actually helps us resist those roles and those performances of white womanhood that then perpetuate collective harm.Danielle (24:49):I can see how that shift would really impact the way one person both connects with their neighbor or a different person, even same race or same culture, and would impact not only how they relate and connect to that person, but also just how they might love.Jenny (25:10):Yeah, because I think it is dangerous. It is disproportionately dangerous to oppressed bodies when white women aren't holding our own anger because I think that there is a deferral to the police, to governing bodies to different authorities when a white woman is actually pissed, rather than saying like, Hey, you did this and it pissed me off, let's work it out here. Oftentimes that ends up actually getting policed to authorities that then disproportionately harm oppressed bodies. And so I think it is essential for white women to grow our capacity to bear. No, I actually am pissed and I can acknowledge that and engage that and be with it in myself.I do. I do actually. So I have been working on a book for the last six years in which I'm looking at the socialization of young white women in purity culture and this political moment of Invisible children, which was this documentary style film that manipulated an entire generation of young white women to get involved in missions or development. And so as part of my research, I interviewed many white women who grew up in purity culture and became missionaries. And there were some that maybe still had good relations with organizations such as invisible children and felt threatened or maybe pissed that I was inquiring into this. And so instead of engaging and talking about the emotions that were coming up, they went straight to interrogating my IRB and then went straight to is this research ethical? Even though I could tell they were really just angry and upset about what I was interrogating, and I would've much rather we could have that conversation than this quick sense of I'm going to go to the structures while I can maintain feeling like this demure pleasantness of white womanhood, even though I could feel the energy. And that's an example for me, and I have white privilege, and so there was still threat there, but it was not probably to the same degree that it could be if I didn't hold that same power and privilege that I do.Scared. I felt really scared and I had done everything ethically. I had hired my own IRB to oversee my research. I did their protocol and still I felt the wielding of power and the sense of I can move the system to act against you if I don't like what you're doing. And so it was really, really scary. And then I had to move my anxiety and my body and I had to shake because what I do often when I get scared and I had to let my body discharge that adrenaline and that cortisol, and then I was able to back to myself and respond and say, it sounds like you have some concerns, and being interviewed is totally optional so you don't have to do it. And then I never heard back from 'em, and so it was just helpful for me to get to move that through. Even in part of that process,Danielle (29:27):Jenny, is that energy still in you now or is it gong?Jenny (29:30):Oh yeah, totally. I can feel my body vibrating and even there's that fear of like, oh shit, what's going to happen if I talk about this? I can feel the silencingThe demand to be small and not to expose it because then I'm open to fill in the blank. And so I can feel the sense of how power wants to keep us from speaking truth to power and to those that wield it.Danielle (30:02):Man, I want to swear so bad, motherfucker. I'm not surprised. But I do think I continue to allow myself to be shocked. And I think the thing is, I know this can happen. I know it will happen. I think both you and I are writing on topics that are very interrogate this moment in a very particular way that's threatening. And so although I'm not surprised, I am allowing myself to continually be shocked, not I want to re-traumatize myself, but I don't want to lose the feeling of there might be somebody good out there, this might be well received. And also I want to maintain that feeling of like, man, I really love my friend. I believe in her. And I think allowing myself to kind of hold all those things kind of just allows me to wake up for the moment versus just numbing out to it. Man,So vicious. It's so vicious because you aren't taking their money, you aren't literally hurting them physically. You're not taking their power, and yet there's this full force. You've dedicated your life to this thing and they could take you out.Jenny (31:19):Yeah, and I think it's primarily because I am questioning white women's innocence and I think based on how race and gender work, a white woman's privilege and power comes from this presumed purity and innocence. And so if we start to disrupt that and go, actually, I'm human and I've done some shit and I've, I've caused harm and I will cause harm, and that's actually a really important part of me working out my humanity. Then I'm stepping out of the bounds of being protected under white patriarchy.Danielle (32:06):I feel like I learned, I feel like so much resonance with that. I've had many similar experiences, but one stands out where right after the election I talked with a friend of mine on the phone, and I don't remember if she is a white colleague from same grad school and said something like, oh, it's just a bummer. And we didn't really talk about it. And I was like, that's all you could say. I thought about that. And later I sent a really kind text saying, Hey, that really hurt my feelings. I don't know. It doesn't make sense why we haven't talked about it more. And then I didn't hear back. It just went silent. This is someone I'd known for seven years.(32:45):Then later I called and I was like, Hey, what's up? And they're like, I can't believe you would write that to me If I ever engage you again, I want to start here. Some other random place. I was just sat back and I was like, I'm not giving this any more energy at that time. I said that to myself and it was just like the complete collapse when I said, you hurt my feelings, the complete collapse. When I said, I don't understand this, can we talk about it? And then I went through this period this summer of just having this feeling. I don't want to be at odds with people. So I left this person a voicemail saying, Hey man, can we talk? I haven't heard back from them, but I feel like I did my part. But I'm just struck it even in down from the big view, like the 30,000 foot view or how that person wants to reign the system on you to even interpersonally, if I don't like what you said, I'm just going to remove my presence,Jenny (33:51):Which I think again, is so much of the epidemic of whiteness. And I think it then produces such a fragility that's like I don't actually know how to bear open conflict and disruption because I'm not practiced at it, and I just will escape every time someone calls me to accountability or says something I don't like. And we can't stay in that place of tension.Yeah. Well, I think one is that I feel those tendencies so much in my own body, and I do think that we have capacity to metabolize them. And so I literally might say something like, great, could you let your body get up and run around the room or run in place? Or maybe you stay seated but you let your legs and your arms kick. And they think that if we even just let ourselves express I want to fight, or if I want to flee or I want to get away from this and we let our body do what we need to do, we can then come back to ourselves and have fuller access to our capacity. And again, sometimes I do think there are relationships or communities or things that we do need to step away from. And sometimes if we've only ever learned to say yes, we might go through a process where we swing to the other side and we just cut everyone out and then we get to learn how to have discernment and how to enter into relationships thoughtfully and how to know who are those people we will be investing in probably for a long time.(35:43):And so it's not denying that those impulses are there, but it's letting our bodies metabolize them and work through them. And it makes me think of res, menkin talks about dirty pain versus clean pain, and I think dirty pain is just like, this hurts. I'm going to avoid it. And just disconnect and dissociate clean pain is like this hurts and I'm going to press into it and I'm going to see what it can teach me and how I can grow into a stronger, more mature person through this process.Danielle (36:16):Man, that sounds like some good work you could do with somebody. I think the thing about therapy, coming back to what you said at the beginning is I think we want a quick answer. We want, we want to go to a retreat, we want to show up at the gym. In my case, I go to the gym often. We want to go somewhere, we want to feel like we did it, we accomplished it. And often at the gym, I can hear my coaches are saying just little steps. Every week and above doing lots of weight, it's showing up as much as you can, being consistent. And I kind of hear that in a little bit of what you're saying. It's not like getting to the end right away. It's tracking your body and the sensations and showing up for yourself even in that way.Jenny (37:08):And I think even like that, I love that analogy. I often say relationships are like muscles. They're only as strong as the ruptures that they can handle. And stronger muscles have had more and more and more and more ruptures. We build muscle through tearing and rebuilding. And I think that that's the same with relationship too. But if we've never torn, then we're so afraid of what's going to happen. If there is a rupture,Danielle:I don't know that we're going to heal that, but someone recently said the system is collapsing. It really is. It's coming down on itself. And I think really it's going to come down to the work that you talked about at the beginning, however people are choosing to see it. But one way you talked about it was that monochromatic lens and adding a lens, adding a lens. And I do think the challenge for all of us, even to form something new, whether that means new government, I don't know what it means, but just even a new way of being together set the government aside. It means really forming, adding lenses to ourselves. Jenny, I hope you're coming back to talk to me again.It's okay. Where can they find your stuff? Tell me.Jenny (38:42):Yeah, so I'm on Instagram at indwell movement, and then my website is indwell movement.com. So find me at either of those places, email me, reach out, send a message, would love to connect.Danielle (38:59):Okay, cool. Well, that's a wrap on this episode. If you can share, download, subscribe, tune into what we're talking about. But more important, have a conversation with a friend, a colleague, a neighbor, challenge your therapist, challenge your family. Don't forget to keep talking. And at the end of the show notes are resources, just some resources. They aren't the end all, be all of resources, but I'm putting 'em in there because I want you to know it's important to do resourcing for ourselves. As always, thank you for joining us, and at the end of the podcast are notes and resources, and I encourage you to stay connected to those who are loving in your path and in your community. Stay tuned.  Crisis Resources:Kitsap County & Washington State Crisis and Mental Health ResourcesIf you or someone else is in immediate danger, please call 911.This resource list provides crisis and mental health contacts for Kitsap County and across Washington State.Kitsap County / Local ResourcesResource Contact Info What They OfferSalish Regional Crisis Line / Kitsap Mental Health 24/7 Crisis Call Line Phone: 1‑888‑910‑0416Website: https://www.kitsapmentalhealth.org/crisis-24-7-services/ 24/7 emotional support for suicide or mental health crises; mobile crisis outreach; connection to services.KMHS Youth Mobile Crisis Outreach Team Emergencies via Salish Crisis Line: 1‑888‑910‑0416Website: https://sync.salishbehavioralhealth.org/youth-mobile-crisis-outreach-team/ Crisis outreach for minors and youth experiencing behavioral health emergencies.Kitsap Mental Health Services (KMHS) Main: 360‑373‑5031; Toll‑free: 888‑816‑0488; TDD: 360‑478‑2715Website: https://www.kitsapmentalhealth.org/crisis-24-7-services/ Outpatient, inpatient, crisis triage, substance use treatment, stabilization, behavioral health services.Kitsap County Suicide Prevention / “Need Help Now” Call the Salish Regional Crisis Line at 1‑888‑910‑0416Website: https://www.kitsap.gov/hs/Pages/Suicide-Prevention-Website.aspx 24/7/365 emotional support; connects people to resources; suicide prevention assistance.Crisis Clinic of the Peninsulas Phone: 360‑479‑3033 or 1‑800‑843‑4793Website: https://www.bainbridgewa.gov/607/Mental-Health-Resources Local crisis intervention services, referrals, and emotional support.NAMI Kitsap County Website: https://namikitsap.org/ Peer support groups, education, and resources for individuals and families affected by mental illness.Statewide & National Crisis ResourcesResource Contact Info What They Offer988 Suicide & Crisis Lifeline (WA‑988) Call or text 988; Website: https://wa988.org/ Free, 24/7 support for suicidal thoughts, emotional distress, relationship problems, and substance concerns.Washington Recovery Help Line 1‑866‑789‑1511Website: https://doh.wa.gov/you-and-your-family/injury-and-violence-prevention/suicide-prevention/hotline-text-and-chat-resources Help for mental health, substance use, and problem gambling; 24/7 statewide support.WA Warm Line 877‑500‑9276Website: https://www.crisisconnections.org/wa-warm-line/ Peer-support line for emotional or mental health distress; support outside of crisis moments.Native & Strong Crisis Lifeline Dial 988 then press 4Website: https://doh.wa.gov/you-and-your-family/injury-and-violence-prevention/suicide-prevention/hotline-text-and-chat-resources Culturally relevant crisis counseling by Indigenous counselors.Additional Helpful Tools & Tips• Behavioral Health Services Access: Request assessments and access to outpatient, residential, or inpatient care through the Salish Behavioral Health Organization. Website: https://www.kitsap.gov/hs/Pages/SBHO-Get-Behaviroal-Health-Services.aspx• Deaf / Hard of Hearing: Use your preferred relay service (for example dial 711 then the appropriate number) to access crisis services.• Warning Signs & Risk Factors: If someone is talking about harming themselves, giving away possessions, expressing hopelessness, or showing extreme behavior changes, contact crisis resources immediately.Well, first I guess I would have to believe that there was or is an actual political dialogue taking place that I could potentially be a part of. And honestly, I'm not sure that I believe that. Well, first I guess I would have to believe that there was or is an actual political dialogue taking place that I could potentially be a part of. And honestly, I'm not sure that I believe that.

** There are less than 10 tickets remaining for the live recording of Uncommons with Catherine McKenna on Thursday Oct 2nd. Register for free here. **On this two-part episode of Uncommons, Nate digs into Bill C-2 and potential impacts on privacy, data surveillance and sharing with US authorities, and asylum claims and refugee protections.In the first half, Nate is joined by Kate Robertson, senior researcher at the University of Toronto's Citizen Lab. Kate's career has spanned criminal prosecutions, regulatory investigations, and international human rights work with the United Nations in Cambodia. She has advocated at every level of court in Canada, clerked at the Supreme Court, and has provided pro bono services through organizations like Human Rights Watch Canada. Her current research at Citizen Lab examines the intersection of technology, privacy, and the law.In part two, Nate is joined by Adam Sadinsky, a Toronto-based immigration and refugee lawyer and co-chair of the Canadian Association of Refugee Lawyers' Advocacy Committee. Adam has represented clients at every level of court in Canada, including the Supreme Court, and was co-counsel in M.A.A. v. D.E.M.E. (2020 ONCA 486) and Canadian Council for Refugees v. Canada (2023 SCC 17).Further Reading:Unspoken Implications A Preliminary Analysis of Bill C-2 and Canada's Potential Data-Sharing Obligations Towards the United States and Other Countries - Kate Robertson, Citizen LabKate Robertson Chapters:00:00 Introduction & Citizen Lab03:00 Bill C-2 and the Strong Borders Act08:00 Data Sharing and Human Rights Concerns15:00 The Cloud Act & International Agreements22:00 Real-World Examples & Privacy Risks28:00 Parliamentary Process & Fixing the BillAdam Sadinsky Chapters:33:33 Concerns Over Asylum Eligibility in Canada36:30 Government Goals and Fairness for Refugee Claimants39:00 Changing Country Conditions and New Risks41:30 The Niagara Falls Example & Other Unfair Exclusions44:00 Frivolous vs. Legitimate Claims in the Refugee System47:00 Clearing the Backlog with Fair Pathways50:00 Broad Powers Granted to the Government52:00 Privacy Concerns and Closing ReflectionsPart 1: Kate RobertsonNate Erskine-Smith00:00-00:01Kate, thanks for joining me.Kate Robertson00:01-00:01Thanks for having me.Nate Erskine-Smith00:02-00:15So I have had Ron Debert on the podcast before. So for people who really want to go back into the archive, they can learn a little bit about what the Citizen Lab is. But for those who are not that interested, you're a senior researcher there. What is the Citizen Lab?Kate Robertson00:16-01:00Well, it's an interdisciplinary research lab based at University of Toronto. It brings together researchers from a technology standpoint, political science, lawyers like myself and other disciplines to examine the intersection between information and communication technologies, law, human rights, and global security. And over time, it's published human rights reports about some of the controversial and emerging surveillance technologies of our time, including spyware or AI-driven technologies. And it's also really attempted to produce a thoughtful research that helps policymakers navigate some of these challenges and threats.Nate Erskine-Smith01:01-02:50That's a very good lead into this conversation because here we have Bill C-2 coming before Parliament for debate this fall, introduced in June, at the beginning of June. And it's called the Strong Borders Act in short, but it touches, I started counting, it's 15 different acts that are touched by this omnibus legislation. The government has laid out a rationale around strengthening our borders, keeping our borders secure, combating transnational organized crime, stopping the flow of illegal fentanyl, cracking down on money laundering, a litany of things that I think most people would look at and say broadly supportive of stopping these things from happening and making sure we're enhancing our security and the integrity of our immigration system and on. You, though, have provided some pretty thoughtful and detailed rational legal advice around some of the challenges you see in the bill. You're not the only one. There are other challenges on the asylum changes we're making. There are other challenges on lawful access and privacy. You've, though, highlighted, in keeping with the work of the Citizen Lab, the cross-border data sharing, the challenges with those data sharing provisions in the bill. It is a bit of a deep dive and a little wonky, but you've written a preliminary analysis of C2 and Canada's potential data sharing obligations towards the U.S. and other countries, unspoken implications, and you published it mid-June. It is incredibly relevant given the conversation we're having this fall. So if you were to at a high level, and we'll go ahead and some of the weeds, but at a high level articulate the main challenges you see in the legislation from the standpoint that you wrote in unspoken implications. Walk us through them.Kate Robertson02:51-06:15Well, before C2 was tabled for a number of years now, myself and other colleagues at the lab have been studying new and evolving ways that we're seeing law enforcement data sharing and cross-border cooperation mechanisms being put to use in new ways. We have seen within this realm some controversial data sharing frameworks under treaty protocols or bilateral agreement mechanisms with the United States and others, which reshape how information is shared with law enforcement in foreign jurisdictions and what kinds of safeguards and mechanisms are applied to that framework to protect human rights. And I think as a really broad trend, what is probably most, the simplest way to put it is that what we're really seeing is a growing number of ways that borders are actually being exploited to the detriment of human rights standards. Rights are essentially falling through the cracks. This can happen either through cross-border joint investigations between agencies in multiple states in ways that essentially go forum shopping for the laws and the most locks, that's right. You can also see foreign states that seek to leverage cooperation tools in democratic states in order to track, surveil, or potentially even extradite human rights activists and dissidents, journalists that are living in exile outside their borders. And what this has really come out of is a discussion point that has been made really around the world that if crime is going to become more transient across borders, that law enforcement also needs to have a greater freedom to move more seamlessly across borders. But what often is left out of that framing is that human rights standards that are really deeply entrenched in our domestic law systems, they would also need to be concurrently meaningful across borders. And unfortunately, that's not what we're seeing. Canada is going to be facing decisions around this, both within the context of C2 and around it in the coming months and beyond, as we know that it has been considering and in negotiation around a couple of very controversial agreements. One of those, the sort of elephant in the room, so to speak, is that the legislation has been tabled at a time where we know that Canada and the United States have been in negotiations for actually a couple of years around a potential agreement called the CLOUD Act, which would quite literally cede Canada's sovereignty to the United States and law enforcement authorities and give them really a blanket opportunity to directly apply surveillance orders onto entities, both public and private in Canada?Nate Erskine-Smith06:16-07:46Well, so years in the making negotiations, but we are in a very different world with the United States today than we were two years ago. And I was just in, I was in Mexico City for a conference with parliamentarians across the Americas, and there were six Democratic congressmen and women there. One, Chuy Garcia represents Chicago district. He was telling me that he went up to ICE officials and they're masked and he is saying, identify yourself. And he's a congressman. He's saying, identify yourself. What's your ID? What's your badge number? They're hiding their ID and maintaining masks and they're refusing to identify who they are as law enforcement officials, ostensibly refusing to identify who they are to an American congressman. And if they're willing to refuse to identify themselves in that manner to a congressman. I can only imagine what is happening to people who don't have that kind of authority and standing in American life. And that's the context that I see this in now. I would have probably still been troubled to a degree with open data sharing and laxer standards on the human rights side, but all the more troubling, you talk about less democratic jurisdictions and authoritarian regimes. Well, isn't the U.S. itself a challenge today more than ever has been? And then shouldn't we maybe slam the pause button on negotiations like this? Well, you raise a number of really important points. And I think thatKate Robertson07:47-09:54there have been warning signs and worse that have long preceded the current administration and the backsliding that you're commenting upon since the beginning of 2025. Certainly, I spoke about the increasing trend of the exploitation of borders. I mean, I think we're seeing signs that really borders are actually, in essence, being used as a form of punishment, even in some respects, which I would say it is when you say to someone who would potentially exercise due process rights against deportation and say if you exercise those rights, you'll be deported to a different continent from your home country where your rights are perhaps less. And that's something that UN human rights authorities have been raising alarm bells about around the deportation of persons to third countries, potentially where they'll face risks of torture even. But these patterns are all too reminiscent of what we saw in the wake of 9-11 and the creation of black sites where individuals, including Canadian persons, were detained or even tortured. And really, this stems from a number of issues. But what we have identified in analyzing potential cloud agreement is really just the momentous decision that the Canadian government would have to make to concede sovereignty to a country which is in many ways a pariah for refusing to acknowledge extraterritorial international human rights obligations to persons outside of its borders. And so to invite that type of direct surveillance and exercise of authority within Canada's borders was a country who has refused for a very long time, unlike Canada and many other countries around the world, has refused to recognize through its courts and through its government any obligation to protect the international human rights of people in Canada.Nate Erskine-Smith09:56-10:21And yet, you wrote, some of the data and surveillance powers in Bill C-2 read like they could have been drafted by U.S. officials. So you take the frame that you're just articulating around with what the U.S. worldview is on this and has been and exacerbated by obviously the current administration. But I don't love the sound of it reading like it was drafted by AmericanKate Robertson10:22-12:43officials. Well, you know, it's always struck me as a really remarkable story, to be frank. You know, to borrow Dickens' tale of two countries, which is that since the 1990s, Canada's Supreme Court has been charting a fundamentally different course from the constitutional approach that's taken the United States around privacy and surveillance. And it really started with persons looking at what's happening and the way that technology evolves and how much insecurity people feel when they believe that surveillance is happening without any judicial oversight. And looking ahead and saying, you know what, if we take this approach, it's not going to go anywhere good. And that's a really remarkable decision that was made and has continued to be made by the court time and time again, even as recently as last year, the court has said we take a distinct approach from the United States. And it had a lot of foresight given, you know, in the 1990s, technology is nowhere near what it is today. Of course. And yet in the text of C2, we see provisions that, you know, I struggle when I hear proponents of the legislation describe it as balanced and in keeping with the Charter, when actually they're proposing to essentially flip the table on principles that have been enshrined for decades to protect Canadians, including, for example, the notion that third parties like private companies have the authority to voluntarily share our own. information with the police without any warrant. And that's actually the crux of what has become a fundamentally different approach that I think has really led Canada to be a more resilient country when it comes to technological change. And I sometimes describe us as a country that is showing the world that, you know, it's possible to do both. You can judicially supervise investigations that are effective and protect the public. And the sky does not fall if you do so. And right now we're literally seeing and see to something that I think is really unique and important made in Canada approach being potentially put on the chopping block.Nate Erskine-Smith12:44-13:29And for those listening who might think, okay, well, at a high level, I don't love expansive data sharing and reduced human rights protections, but practically, are there examples? And you pointed to in your writing right from the hop, the Arar case, and you mentioned the Supreme Court, but they, you know, they noted that it's a chilling example of the dangers of unconditional information sharing. And the commission noted to the potentially risky exercise of open ended, unconditional data sharing as well. But that's a real life example, a real life Canadian example of what can go wrong in a really horrible, tragic way when you don't have guardrails that focus and protect human rights.Kate Robertson13:31-14:56You're right to raise that example. I raise it. It's a really important one. It's one that is, I think, part of, you know, Canada has many commendable and important features to its framework, but it's not a perfect country by any means. That was an example of just information sharing with the United States itself that led to a Canadian citizen being rendered and tortured in a foreign country. Even a more recent example, we are not the only country that's received requests for cooperation from a foreign state in circumstances where a person's life is quite literally in jeopardy. We have known from public reporting that in the case of Hardeep Najjar, before he was ultimately assassinated on Canadian soil, an Interpol Red Notice had been issued about him at the request of the government of India. And the government had also requested his extradition. And we know that there's a number of important circumstances that have been commented upon by the federal government in the wake of those revelations. And it's provoked a really important discussion around the risks of foreign interference. But it is certainly an example where we know that cooperation requests have been made in respect of someone who's quite literally and tragically at risk of loss of life.Nate Erskine-Smith14:57-16:07And when it comes to the, what we're really talking about is, you mentioned the Cloud Act. There's also, I got to go to the notes because it's so arcane, but the second additional protocol to the Budapest Convention. These are, in that case, it's a treaty that Canada would ratify. And then this piece of legislation would in some way create implementing authorities for. I didn't fully appreciate this until going through that. And I'd be interested in your thoughts just in terms of the details of these. And we can make it as wonky as you like in terms of the challenges that these treaties offer. I think you've already articulated the watering down of traditional human rights protections and privacy protections we would understand in Canadian law. But the transparency piece, I didn't fully appreciate either. And as a parliamentarian, I probably should have because there's... Until reading your paper, I didn't know that there was a policy on tabling of treaties That really directs a process for introducing treaty implementing legislation. And this process also gets that entirely backwards.Kate Robertson16:09-17:01That's right. And, you know, in researching and studying what to do with, you know, what I foresee is potentially quite a mess if we were to enter into a treaty that binds us to standards that are unconstitutional. You know, that is a diplomatic nightmare of sorts, but it's also one that would create, you know, a constitutional entanglement of that's really, I think, unprecedented in Canada. But nevertheless, that problem is foreseen if one or both of these were to go ahead. And I refer to that in the cloud agreement or the 2AP. But this policy, as I understand it, I believe it was tabled by then Foreign Affairs Minister Maxime Bernier, as he was at the time, by Prime Minister Harper's government.Nate Erskine-Smith17:02-17:04He's come a long way.Kate Robertson17:07-18:12I believe that the rationale for the policy was quite self-evident at the time. I mean, if you think about the discussions that are happening right now, for example, in Quebec around digital sovereignty and the types of entanglements that U.S. legal process might impact around Quebec privacy legislation. Other issues around the AI space in Ontario or our health sector in terms of technology companies in Ontario. These treaties really have profound implications at a much broader scale than the federal government and law enforcement. And that's not even getting to Indigenous sovereignty issues. And so the policy is really trying to give a greater voice to the range of perspectives that a federal government would consider before binding Canada internationally on behalf of all of these layers of decision making without perhaps even consulting with Parliament First.Nate Erskine-Smith18:12-19:15So this is, I guess, one struggle. There's the specific concerns around watering down protections, but just on process. This just bothered me in particular because we're going to undergo this process in the fall. And so I printed out the Strong Borders Act, Government of Canada Strengthens Border Security and the backgrounder to the law. And going through it, it's six pages when I print it out. And it doesn't make mention of the Budapest Convention. It doesn't make mention of the Cloud Act. It doesn't make mention of any number of rationales for this legislation. But it doesn't make mention that this is in part, at least, to help implement treaties that are under active negotiation. not only gets backwards the policy, but one would have thought, especially I took from your paper, that the Department has subsequently, the Justice Department has subsequently acknowledged that this would in fact help the government implement these treaties. So surely it shouldKate Robertson19:15-19:57be in the background. I would have thought so. As someone that has been studying these treaty frameworks very carefully, it was immediately apparent to me that they're at least relevant. It was put in the briefing as a question as to whether or not the actual intent of some of these new proposed powers is to put Canada in a position to ratify this treaty. And the answer at that time was yes, that that is the intent of them. And it was also stated that other cooperation frameworks were foreseeable.Nate Erskine-Smith19:59-20:57What next? So here I am, one member of parliament, and oftentimes through these processes, we're going to, there's the objective of the bill, and then there's the details of the bill, and we're going to get this bill to a committee process. I understand the intention is for it to be a pretty fulsome committee hearing, and it's an omnibus bill. So what should happen is the asylum components should get kicked to the immigration committee. The pieces around national security should obviously get kicked to public safety committee, and there should be different committees that deal with their different constituent elements that are relevant to those committees. I don't know if it will work that way, but that would be a more rational way of engaging with a really broad ranging bill. Is there a fix for this though? So are there amendments that could cure it or is it foundationally a problem that is incurable?Kate Robertson20:58-21:59Well, I mean, I think that for myself as someone studying this area, it's obvious to me that what agreements may be struck would profoundly alter the implications of pretty much every aspect of this legislation. And that stems in part from just how fundamental it would be if Canada were to cede its sovereignty to US law enforcement agencies and potentially even national security agencies as well. But obviously, the provisions themselves are quite relevant to these frameworks. And so it's clear that Parliament needs to have the opportunity to study how these provisions would actually be used. And I am still left on knowing how that would be possible without transparencyNate Erskine-Smith22:00-22:05about what is at stake in terms of potential agreements. Right. What have we agreed to? If thisKate Robertson22:05-24:57is implementing legislation what are we implementing certainly it's a significantly different proposition now even parking the international data sharing context the constitutional issues that are raised in the parts of the bill that i'm able to study within my realm of expertise which is in the context of omnibus legislation not the entire bill of course yeah um but it's hard to even know where to begin um the the the powers that are being put forward you know i kind of have to set the table a bit to understand to explain why the table is being flipped yeah yeah we're at a time where um you know a number of years ago i published about the growing use of algorithms and AI and surveillance systems in Canada and gaps in the law and the need to bring Canada's oversight into the 21st century. Those gaps now, even five years later, are growing into chasms. And we've also had multiple investigative reports by the Privacy Commissioner of Canada being sent to Parliament about difficulties it's had reviewing the activities of law enforcement agencies, difficulties it's had with private sector companies who've been non-compliant with privacy legislation, and cooperating at all with the regulator. And we now have powers being put forward that would essentially say, for greater certainty, it's finders keepers rules. Anything in the public domain can be obtained and used by police without warrant. And while this has been put forward as a balancing of constitutional norms, the Supreme Court has said the opposite. It's not an all or nothing field. And in the context of commercial data brokers that are harvesting and selling our data, including mental health care that we might seek online, AI-fueled surveillance tools that are otherwise unchecked in the Canadian domain. I think this is a frankly stunning response to the context of the threats that we face. And I really think it sends and creates really problematic questions around what law enforcement and other government agencies are expected to do in the context of future privacy reviews when essentially everything that's been happening is supposedly being green lit with this new completely un-nuanced power. I should note you are certainly not alone in theseNate Erskine-Smith24:57-27:07concerns. I mean, in addition to the paper that I was talking about at the outset that you've written as an analyst that alongside Ron Deaver in the Citizen Lab. But there's another open letter you've signed that's called for the withdrawal of C2, but it's led by open media. I mean, BCCLA, British Columbia Civil Liberties Association, the Canadian Civil Liberties Association, the Canadian Council for Refugees, QP, International Civil Liberties Monitoring Group, Penn Canada, the Center for Free Expression, privacy experts like Colin Bennett, who I used be on the Privacy Committee and that were pretty regular witnesses. You mentioned the Privacy Commissioner has not signed the open letter, but the Privacy Commissioner of both Canada and the Information Commissioner of Ontario, who's also responsible for privacy. In the context of the treaties that you were mentioning, the Budapest Convention in particular, they had highlighted concerns absent updated, modernized legislation. And at the federal level, we have had in fits and starts attempts to modernize our private sector privacy legislation. But apart from a consultation paper at one point around the Privacy Act, which would apply to public sector organizations, there's really been no serious effort to table legislation or otherwise modernize that. So am I right to say, you know, we are creating a myriad number of problems with respect to watering down privacy and human rights protections domestically and especially in relation to foreign governments with relation to data of our citizens here. And we could potentially cure those problems, at least in part, if we modernize our privacy legislation and our privacy protections and human rights protections here at home. But we are, as you say, a gap to chasm. We are so woefully behind in that conversation. It's a bit of an odd thing to pass the open-ended data sharing and surveillance piece before you even have a conversation around updating your privacy protections.Kate Robertson27:07-28:13Yeah, I mean, frankly, odd, I would use the word irresponsible. We know that these tools, it's becoming increasingly well documented how impactful they are for communities and individuals, whether it's wrongful arrests, whether it's discriminatory algorithms. really fraught tools to say the least. And it's not as if Parliament does not have a critical role here. You know, in decades past, to use the example of surveillance within Quebec, which was ultimately found to have involved, you know, years of illegal activity and surveillance activities focused on political organizing in Quebec. And that led to Parliament striking an inquiry and ultimately overhauling the mandate of the RCMP. There were recommendations made that the RCMP needs to follow the law. That was an actual recommendation.Nate Erskine-Smith28:14-28:16I'm sorry that it needs to be said, but yeah.Kate Robertson28:16-29:05The safeguards around surveillance are about ensuring that when we use these powers, they're being used appropriately. And, you know, there isn't even, frankly, a guarantee that judicial oversight will enable this to happen. And it certainly provides comfort to many Canadians. But we know, for example, that there were phones being watched of journalists in Montreal with, unfortunately, judicial oversight not even that many years ago. So this is something that certainly is capable of leading to more abuses in Canada around political speech and online activity. And it's something that we need to be protective against and forward thinking about.Nate Erskine-Smith29:05-29:58Yeah, and the conversation has to hold at the same time considerations of public safety, of course, but also considerations for due process and privacy and human rights protections. These things, we have to do both. If we don't do both, then we're not the democratic society we hold ourselves out as. I said odd, you said irresponsible. You were forceful in your commentary, but the open letter that had a number of civil society organizations, I mentioned a few, was pretty clear to say the proposed legislation reflects little more than shameful appeasement of the dangerous rhetoric and false claims about our country emanating from the United States. It's a multi-pronged assault on the basic human rights and freedoms Canada holds dear. Got anything else to add?Kate Robertson30:00-30:56I mean, the elephant in the room is the context in which the legislation has been tabled within. And I do think that we're at a time where we are seeing democratic backsliding around the world, of course, and rising digital authoritarianism. And these standards really don't come out of the air. They're ones that need to be protected. And I do find myself, when I look at some of the really un-nuanced powers that are being put forward, I do find myself asking whether or not those risks are really front and center when we're proposing to move forward in this way. And I can only defer to experts from, as you said, hundreds of organizations that have called attention towards pretty much every aspect of this legislation.Nate Erskine-Smith30:57-31:44And I will have the benefit of engaging folks on the privacy side around lawful access and around concerns around changes to the asylum claim and due process from the Canadian Association of Refugee Lawyers. But as we do see this move its way through Parliament, if we see it move its way through Parliament in the fall, if they're recognizing that the call was for withdrawal, but also recognizing a political reality where if it is to pass, we want to make sure we are improving it as much as possible. If there are amendments along the way, if there are other people you think that I should engage with, please do let me know because this is before us. It's an important piece of legislation. And if it's not to be withdrawn, we better improve it as much as possible.Kate Robertson31:46-32:02I appreciate that offer and really commend you for covering the issue carefully. And I really look forward to more engagement from yourself and other colleagues in parliament as legislation is considered further. I expect you will be a witness at committee,Nate Erskine-Smith32:02-32:06but thanks very much for the time. I really appreciate it. Thanks for having me.Part 2: Adam SadinskyChapters:33:33 Concerns Over Asylum Eligibility in Canada36:30 Government Goals and Fairness for Refugee Claimants39:00 Changing Country Conditions and New Risks41:30 The Niagara Falls Example & Other Unfair Exclusions44:00 Frivolous vs. Legitimate Claims in the Refugee System47:00 Clearing the Backlog with Fair Pathways50:00 Broad Powers Granted to the Government52:00 Privacy Concerns and Closing ReflectionsNate Erskine-Smith33:33-33:35Adam, thanks for joining me.Adam Sadinsky33:35-33:36Thanks for having me, Nate.Nate Erskine-Smith33:36-33:57We've had a brief discussion about this, by way of my role as an MP, but, for those who are listening in, they'll have just heard a rundown of all the concerns that the Citizen Lab has with data surveillance and data sharing with law enforcement around the world. You've got different concerns about C2 and you represent the Canadian Association of Refugee Lawyers. What are your concerns here?Adam Sadinsky33:57-35:31I mean, our biggest concern with this bill is new provisions that create additional categories of folks ineligible to claim asylum in Canada. And specifically to have their hearings heard at the Immigration and Refugee Board. The biggest one of those categories is definitely, a bar on individuals making refugee claims in Canada one year after they have arrived in Canada, and that's one year, whether they have been in Canada for that whole year or they left at some point and came back. Those folks who have been here, who came more than a year ago, if they now fear persecution and want to make a claim for refugee protection, this bill would shunt them into an inferior system where rather than having a full hearing in their day in court.Their application will be decided by an officer of immigration, alone, sitting in the cubicle, probably, with some papers in front of them. That person is going to make an enormous decision about whether to send that person back home where they feared persecution, torture, death. Our position is that this new form of ineligibility. Is unfair. it doesn't meet the government's goals, as we understand them, and we share, we share the views of organizations like, Citizen Lab, that the bill should be withdrawn. There are other ways to do this, but this bill is fundamentally flawed.Nate Erskine-Smith35:31-35:57Let's talk about government goals. Those looking at the influx of temporary residents in Canada specifically, and I don't, and I don't wanna pick on international students, but we've seen a huge influx of international students just as one category example. And they've said, well, if someone's been here for a year and they didn't claim right away, they didn't come here to claim asylum. Because they would've claimed within that first year, presumably, you know, what's the problem with, uh, with a rule that is really trying to tackle this problem.Adam Sadinsky35:57-38:33The issue is, I mean, Nate, you had mentioned, you know, people who had come to Canada, they didn't initially claim and it didn't initially claim asylum, temporary residents. What do we do about it? I wanna give a couple of examples of people who would be caught by this provision, who fall into that category. But there's legitimate reasons why they might claim more than a year after arriving in Canada. The first is someone who came to Canada, student worker, whatever. At the time they came to Canada, they would've been safe going back home they didn't have a fear of returning back home. But country conditions change and they can change quickly. The Taliban takeover of Afghanistan in 2021, was a stark example there may have been people who came to Canada as students planning to go back to Afghanistan and rebuild their country. As the bill is currently written. If there were to be a situation like that, and there will be some other Afghanistan, there will be some other situation down the line. Those people who weren't afraid when they originally came to Canada and now have a legitimate claim, will have an inferior, process that they go through, one that is riddled with issues, examples of unfairness compared to the refugee, the regular refugee system, and a lack of protection from deportation, pending any appeal.So that's one category. A second category is people who were afraid of going back home when they came to Canada but didn't need to claim asylum because they had another avenue to remain in Canada. So the government advertised, Minister Frazier was saying this often come to Canada, come as a student and there's a well-established pathway. You'll have a study permit, you'll get a post-graduation work permit. This is what the government wanted. The rug has been pulled out from under many of those people. Towards the end of last year when Canada said, okay, it's enough, too many temporary residents. But what about the temporary residents who had a fear of returning home when they came? They went through the system the “right way,” quote unquote. They didn't go to the asylum system. they went through another path. And now they're looking at it. They say, well, you know, I came to Canada to study, but also I'm gay and I'm from a country where, if people know about that, you know, I'll be tortured. Maybe since they've been in Canada, that person in that example, they've been in a relationship, they've been posting on social media with their partner. It is very dangerous so why, why shouldn't that person claim refugee protection through regular means?Nate Erskine-Smith38:33-39:06Is this right on your read of the law as it is written right now, if someone were to come with their family when they're a kid and they were to be in Canada for over a year and then their family were to move back to either the home country or to a different country, and, they wake up as a teenager many years later, they wake up as an adult many years later and their country's falling apart, and they were to flee and come to Canada. By virtue of the fact they've been here for a year as a kid, would that preclude them from making a claim?Adam Sadinsky39:06-39:10It's even worse than that, Nate.Nate Erskine-Smith39:09-39:10Oh, great.Adam Sadinsky39:10-39:47In your example, the family stayed in Canada for more than a year. Yes, absolutely. That person is caught by this provision. But here's who else would be someone comes when they're five years old with their family, on a trip to the United States. during that trip, they decide we want to see the Canadian side of Niagara Falls. They either have a visa or get whatever visa they need, or don't need one. They visit the falls, and at that point that they enter Canada, a clock starts ticking. That never stops ticking. So maybe they came to Canada for two hours.Nate Erskine-Smith39:44-39:45Two hours and you're outta luck.Adam Sadinsky39:45-39:47They go back to the USNate Erskine-Smith39:47-39:47Oh man.Adam Sadinsky39:47-40:09They never come back to Canada again. The way that the bill is written, that clock never stops ticking, right? Their country falls apart. They come back 15 years later. That person is going to have a very different kind of process that they go through, to get protection in Canada, than someone who wouldn't be caught by this bill.Nate Erskine-Smith40:09-40:34Say those are the facts as they are, that's one category. There's another category where I've come as a student, I thought there would be a pathway. I don't really fear persecution in my home country, but I want to stay in Canada we see in this constituency office, as other constituency offices do people come with immigration help or they've got legitimate claims. We see some people come with help with illegitimate claimsAdam Sadinsky40:34-42:46We have to be very careful when we talk about categorizing claims as frivolous. There is no question people make refugee claims in Canada that have no merit. You'll not hear from me, you'll not hear from our organization saying that every 100% of refugee claims made in Canada, are with merit. The issue is how we determine. At that initial stage that you're saying, oh, let's, let's deal quickly with frivolous claims. How do you determine if a claim is frivolous? What if someone, you know, I do a lot of appeal work, we get appeals of claims prepared by immigration consultants, or not even immigration consultants. And, you know, there's a core of a very strong refugee claim there that wasn't prepared properly.Nate Erskine-Smith42:46-42:46Yeah, we see it too. That's a good point.Adam Sadinsky42:46-42:46How that claim was prepared has nothing to do with what the person actually faces back home. We have to be very careful in terms of, quick negative claims, and clearing the decks of what some might think are frivolous claims. But there may be some legitimate and very strong core there. What could be done, and you alluded to this, is there are significant claims in the refugee board's backlog that are very, very strong just based on the countries they come from or the profiles of the individuals who have made those claims, where there are countries that have 99% success rate. And that's not because the board is super generous. It's because the conditions in those countries are very, very bad. And so the government could implement policies and this would be done without legislation to grant pathways for folks from, for example, Eritrea 99ish percent success rate. However, the government wants to deal with that in terms of numbers, but there's no need for the board to spend time determining whether this claim is in the 1%, that doesn't deserve to be accepted. Our view is that 1% being accepted is, a trade off for, a more efficient system.Nate Erskine-Smith42:46-43:30Similarly though, individuals who come into my office and they've been here for more than five years. They have been strong contributors to the community. They have jobs. They're oftentimes connected to a faith organization. They're certainly connected to a community based organization that is going to bat for them. There's, you know, obviously no criminal record in many cases they have other family here. And they've gone through so many appeals at different times. I look at that and I go, throughout Canadian history, there have been different regularization programs. Couldn't you kick a ton of people not a country specific basis, but a category specific basis of over five years, economic contributions, community contributions, no criminal record, you're approved.Adam Sadinsky43:30-44:20Yeah, I'd add to your list of categories, folks who are working in, professions, that Canada needs workers in. give the example of construction. We are facing a housing crisis. So many construction workers are not Canadian. Many of my clients who are refugee claimants waiting for their hearings are working in the construction industry. And the government did that, back in the COVID pandemic, creating what was, what became known as the Guardian Angels Program, where folks who were working in the healthcare sector, on the front lines, combating the pandemic, supporting, folks who needed it, that they were allowed to be taken again out of the refugee queue with a designated, pathway to permanent residents on the basis of the work and the contribution they were doing. All of these could be done.Adam Sadinsky44:20-45:05The refugee system is built on Canada's international obligations under the refugee convention, to claim refugee protection, to claim asylum is a human right. Every person in the world has the right to claim asylum. Individuals who are claiming asylum in Canada are exercising that right. Each individual has their own claim, and that's the real value that the refugee board brings to bear and why Canada has had a gold standard. The refugee system, replicated, around the world, every individual has their day in court, to explain to an expert tribunal why they face persecution. This bill would take that away.Nate Erskine-Smith45:05-46:18Yeah, I can't put my finger on what the other rationale would be though, because why the, why this change now? Well, we have right now, a huge number over a million people who are going to eventually be without status because they're not gonna have a pathway that was originally, that they originally thought would be there. The one frustration I have sometimes in the system is there are people who have come into my office with, the original claim, being unfounded. But then I look at it, and they've been here partly because the process took so long, they've been here for over five years. If you've been here for over five years and you're contributing and you're a member of the community, and now we're gonna kick you out. Like your original claim might have been unfounded, but this is insane. Now you're contributing to this country, and what a broken system. So I guess I'm sympathetic to the need for speed at the front end to ensure that unfounded claims are deemed unfounded and people are deported and legitimate claims are deemed founded, and they can be welcomed. So cases don't continue to come into my office that are over five or over six years long where I go, I don't even care if it was originally unfounded or not. Welcome to Canada. You've been contributing here for six years anyway.Adam Sadinsky46:18-46:33But if I can interject? Even if the bill passes as written, each of these individuals is still going to have what's called a pre-removal risk assessment.Nate Erskine-Smith46:31-46:33They're still gonna have a process. Yeah, exactly.Adam Sadinsky46:33-46:55They're still gonna have a process, and they're still going to wait time. All these people are still in the system. The bill is a bit of a shell game where folks are being just transferred from one process to another and say, oh, wow. Great. Look, we've reduced the backlog at the IRB by however many thousand claims,Nate Erskine-Smith46:53-46:55And we've increased the backlog in the process.Adam Sadinsky46:55-48:25Oh, look at the wait time at IRCC, and I'm sure you have constituents who come into your office and say, I filed a spousal sponsorship application two and a half years ago. I'm waiting for my spouse to come and it's taking so long. IRCC is not immune from processing delays. There doesn't seem to be, along with this bill, a corresponding hiring of hundreds and hundreds more pro officers. So, this backlog and this number of claims is shifting from one place to another. And another point I mentioned earlier within the refugee system within the board, when a person appeals a negative decision, right? Because, humans make decisions and humans make mistakes. And that's why we have legislative appeal processes in the system to allow for mistakes to be corrected. That appeal process happens within the board, and a person is protected from deportation while they're appealing with a pro. With this other system, it's different. The moment that an officer makes a negative decision on a pro that person is now eligible to be deported. CBSA can ask them to show up the next day and get on a plane and go home. Yes, a person can apply for judicial review in the federal court that does not stop their deportation. If they can bring a motion to the court for a stay of removal.Nate Erskine-Smith48:19-48:25You're gonna see a ton of new work for the federal court. You are gonna see double the work for the federal courtAdam Sadinsky48:25-48:39Which is already overburdened. So unless the government is also appointing many, many new judges, and probably hiring more Council Department of Justice, this backlog is going to move from one place to another.Nate Erskine-Smith48:39-48:41It's just gonna be industry whack-a-mole with the backlog.Adam Sadinsky48:41-48:52The only way to clear the backlog is to clear people out of it. There's no fair way to clear folks out of it in a negative way. So the only way to do that is positively.Nate Erskine-Smith48:52-49:37In the limited time we got left, the bill also empowers the governor and council of the cabinet to cancel documents, to suspend documents. And just so I've got this clearer in my mind, so if, for example: say one is a say, one is a student on campus, or say one is on a, on a work permit and one is involved in a protest, and that protest the government deems to be something they don't like. The government could cancel the student's permit on the basis that they were involved in the protest. Is that right? The law? Not to say that this government would do that. But this would allow the government to legally do just that. Am I reading it wrong?Adam Sadinsky49:37-50:46The bill gives broad powers to the government to cancel documents. I think you're reading it correctly. To me, when I read the bill, I don't particularly understand exactly what is envisioned. Where it would, where the government would do this, why a government would want to put this in. But you are right. I would hope this government would not do that, but this government is not going to be in power forever. When you put laws on the books, they can be used by whomever for whatever reason they can they want, that's within how that law is drafted. You know, we saw down south, you know, the secretary of State a few months ago said, okay, we're gonna cancel the permits of everyone from South Sudan, in the US because they're not taking back people being deported. It's hugely problematic. It's a complete overreach. It seems like there could be regulations that are brought in. But the power is so broad as written in this law, that it could definitely be used, for purposes most Canadians would not support.Nate Erskine-Smith50:46-51:07And, obviously that's a worst case scenario when we think about the United States in today's political climate. But, it's not clear to your point what the powers are necessary for. If we are to provide additional powers, we should only provide power as much as necessary and proportionate to the goal we want to achieve. Is there anything else you want to add?Adam Sadinsky51:07-51:43I just wanna touch, and I'm sure you got into a lot of these issues, on the privacy side but. The privacy issues in this bill bleed over into the refugee system with broad search powers, um, particularly requiring service providers to provide information, we are concerned these powers could be used by CBSA, for example, to ask a women's shelter, to hand over information about a woman claiming refugee protection or who's undocumented, living in a shelter, we have huge concerns that, you know, these powers will not just be used by police, but also by Canada Border Services and immigration enforcement. I'm not the expert on privacy issues, but we see it we see the specter of those issues as well.Nate Erskine-Smith51:43-52:22That's all the time we got, but in terms of what would help me to inform my own advocacy going forward is, this bill is gonna get to committee. I'm gonna support the bill in committee and see if we can amend it. I know, the position of CARL is withdraw. The position of a number of civil society organizations is to withdraw it. I think it's constructive to have your voice and others at committee, and to make the same arguments you made today with me. Where you have. I know your argument's gonna be withdrawn, you'll say then in the alternative, here are changes that should be made. When you've got a list of those changes in detailed, legislative amendment form, flip them to me and I'll share the ideas around the ministry and around with colleagues, and I appreciate the time. Appreciate the advocacy.Adam Sadinsky52:22-52:24Absolutely. Thank you. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.uncommons.ca

Cremieux went from arguing against the death penalty as a teenager to becoming one of the most influential voices dissecting science online. Now with 250k+ followers on X, he's known for exposing p-hacking, outcome switching, and selection effects that skew research.In this conversation with Niklas, here's what they actually talk about: why effect sizes in journals rarely match FDA data, how gene therapy's real bottleneck is delivery not targets, and why siRNA is the most underrated modality in biotech right now.What you'll hear in this episode:* The heuristics he uses to spot bad research at a glance* Why published effect sizes are often 2–3x inflated compared to FDA data* Selection effects that quietly shape everything from education outcomes to clinical trials* The real bottleneck in gene therapy (delivery, not targets) and why germline bans hold back obvious wins* How pragmatic trials and IRB reform could finally fix a broken system* Why measles might come back and the case for vaccine mandates for kids* The truth about longevity research: most “breakthroughs” just stop early deaths, not extend the right tail* China's clinical trial engine vs the slow US system* The modality he thinks is most underpriced today: siRNAFor builders in science who care more about getting it right than playing along.More about GUEST'S work:* Cremieux's XExplore Infinita City:* Explore the Archive: The Infinita City Times* Visit Infinita City* Join the Builders' Hub on Telegram* Follow Infinita City on X This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.infinitacitytimes.com

Participate in this anonymous 20-30-minute survey here: Chapman University StudyThis year, we've partnered with OPEN and Dr. Amy Moors at Chapman University, a leading non-monogamy researcher, to bring a new level of academic rigor to this research!Why participate: This data directly supports advocacy work – previous surveys helped win legal protections in major cities. Eligibility: 18+ and practice any form of consensual non-monogamy (polyamory, open relationships, swinging, relationship anarchy, etc.)Study details: Chapman University IRB approved (IRB No. #26-13). Research questions: Dr. Amy Moors, moors@chapman.edu. IRB concerns: (714) 628-2833 or irb@chapman.edu.Survey LinkParticipation is completely voluntary and anonymous. Please share with your non-monogamous networks – more voices = better data = stronger advocacy!

You're listening to Burnt Toast! Today, my guest is Denise Hamburger, founder and director of Be Real USA. Be Real is a nonprofit that imagines a world where every child can grow up with a healthy relationship to food and their body. They work with body image researchers, psychologists, teachers and public health officials to design curricula about nutrition and body image that are weight neutral, and inclusive of all genders, abilities, races and body sizes.So many of you reach out to me every September to say, “Oh my God, you're not going to believe what my kid is learning in health class.” Food logs, fitness trackers, other diet tools are far too common in our classrooms— especially in middle and high school health class. Denise is here to help us understand why those assignments are so harmful and talk about what parents and educators can do differently. This episode is free — so please, share it with the parents, teachers and school administrators in your communities! But if you value this conversation, consider supporting our work with a paid subscription. Burnt Toast is 100% reader- and listener-supported. We literally can't do this without you.PS. You can always listen to this pod right here in your email, where you'll also receive full transcripts (edited and condensed for clarity). But please also follow us in Apple Podcasts, Spotify, Stitcher, and/or Pocket Casts! And if you enjoy today's conversation, please tap the heart on this post — likes are one of the biggest drivers of traffic from Substack's Notes, so that's a super easy, free way to support the show!Two Resources You'll Want From This Episode: Here's how to access the BeReal Let's Eat Curriculum: And here's a roundup of everything I've written on diet culture in schools: Episode 211 TranscriptDeniseWell, this all started I would say about 10 years ago. Actually, about 12 years ago. I was an environmental lawyer in my first career—that's what I'm trained to do. I went to law school, was practicing in big law firms. Which has nothing to do with body image, except I was an environmental lawyer who weighed herself every day and got her mood affected by the number on the scale for 40 years. So that's four decades.VirginiaSo many times getting on a scale.DeniseI really felt like I didn't want anyone else, especially young women today, to waste the amount of time and energy that I had wasted distracting them from what they need to be doing in their lives, figuring out their own person possibilities. That's really what you're here to do. And it takes us away from what we're supposed to be doing.With that in mind, I went back to school at the University of Chicago, and I was thinking of get a social work degree and doing something with body image. But then I wrote a paper on my own body image for one of my classes at the School of Social Work and I found 50 years of research on body image. And then 30 years of discussion and research on how to prevent eating disorders and body dissatisfaction. Like, wow, there is so much out there, so much research on this. But I haven't heard any of this. It feels like it's not making its way into resources that people can use.So I started speaking on it, and I was speaking to middle-aged women, and I thought the message that we all would really benefit from would be everybody's got this. Because I feel like, especially my generation, where we didn't really talk about how we felt about our bodies. I'm at the tail end of the Baby Boom. So I'm 62 and I felt that people in my generation—again, I was 50 at the time—weren't in touch with their own feelings on body image. After talking about this for so many years, younger generations have access to it I think a lot more. But I felt like we could all benefit from knowing that everybody's got it—so kind of a common humanity. It's not our fault, which helps with the shame around it.So everyone has it, it's not our fault, and society has given it to us. And I think that this is something that would resonate with my generation. So I started speaking in local libraries and community houses to women my age, and quickly learned that it is really hard to undo decades worth of thought patterns and feelings around food, body and eating. People came to hear me talk about body image, and I think, in general, when I started out, they were hoping I had a new diet.VirginiaOh, I'm sure they were. I'm sure they were like, “Oh, we're going to go hear her talk about how to love your body by making it smaller!”DeniseAbsolutely. And all of the women, because they were women in my workshops, were starting to talk about their daughters. They're saying that my daughter's got this, and she's coming home and saying this. Then in one of my audiences, I had a health teacher at my local high school. There was a health teacher who came and said—this is about 2015—you should hear what the young girls are saying. They've got this new thing called Instagram and and they're seeing pictures of, “perfect” looking people and feeling bad about themselves or feeling flawed in comparison.So she said, “What resources are there for for the students in my class?” And I said, there has got to be something because there is 50 years' of research there, there has got to be something fabulous for you. And I called the professors listed on the the studies. The granddaddy of the industry, Michael Levine, I called him up. I said, “Michael, just tell me, what can I recommend to these teachers?” And he's like, “I don't know. I don't know. We don't have it. It's not there. Even though the research is there.”So there was a curriculum created for high risk kids. It needed to be given by facilitators called The Body Project. And I called one of the professors who wrote The Body Project and said, “Listen, I'd like to give this tool to a teacher for universal,” which means giving it to everybody in the classroom, and and she wants to bring it to her high school, but it looks like you need to be trained. And it was a script. The Body Project was a script. And this teacher said to me, I'm not reading a script in a classroom. You're not going to get a high school teacher to read a script.VirginiaYeah. I would imagine high school students sitting in a classroom aren't going to respond to someone just reading a script at them.DeniseNobody wants to hear it. It's not useful. It wasn't created for that use. So this professor, Carolyn Becker, had actually written a paper on how the academics need to work with stakeholders to make sure that their research makes it to the public. And I said, I'm calling you. I'm a stakeholder. What do you need? And she said, “We need somebody to translate it.” And I said, “I'm your girl.”VirginiaI mean, it's wild that the research has been there. We've known what works, or what strategies to use for so long, and yet it's not in the pedagogy, it's not in the classrooms.So you started with the body image curriculum, BodyKind. And now this year, you've just released your weight neutral nutrition curriculum for middle and high school students, called Let's Eat.Full disclosure: I got to be a early reader of the of the curriculum and offer a few notes. It was already amazing when I read it.DeniseThank you.VirginiaI did not have to add a lot at any by any means, but it was really cool to see the development process, and see where you ended up with it. It's really remarkable. So let's start by talking about why nutrition. You've done the body image thing, that's really powerful. Why was nutrition the next logical place to go?DeniseI have spoken at this point to probably 10,000 teachers. And they're always asking me, what nutrition curriculum do you recommend? Same deal. There's not one out thereAnd I had asked one of my interns to give me her textbook on it, like what are you learning about nutrition? And in my intern's textbook, it was 2018, you saw encapsulated the entire problem of what's wrong with nutrition curriculum.They are asking the children to weigh and measure themselves, and they're asking the children to count calories in different ways, and to track their food. Food logs. Again, these were best practices in the 90s and and 2000s on how to teach nutrition. So this is all over the nutrition curriculum.Then, of course, they're talking about good and bad foods, which foods can you eat, which foods you can't you eat, and all of these things in the research we know cause disordered eating and eating disorders, they all contribute to it. I have a list of probably nine research papers that point to each of these things and tell you why these are bad ideas to have a nutrition class.And we also know there have been two papers written, where they polled students or young people coming in for eating disorder treatment and asked them, what do you think triggered your eating disorder? And around 14% in both studies said, “My healthy eating curriculum at school was where I started getting this obsession.” So you know, what's out there hasn't been helpful, and even worse, has been part of the problem in our society.[Post-recording note: Here's Mallary Tenore Tarpley writing about this research in the Washington Post, and quoting Oona Hanson!]VirginiaIt's so rooted in our moral panic around “the childhood obesity epidemic.” Educators, public health officials, everyone feels like, that's the thing we have to be worried about if we're going to talk about kids and food. It all has to be framed through that lens. And what you are arguing is: That weight-centered approach causes harm. We can see from the data that it's not “fixing” the obesity epidemic. Kids aren't thinner than they were 40 years ago. So it didn't work. And it's having all these unintended ripple effects, or sometimes, I would say, intended ripple effects.DeniseYes, exactly. Studies on nutrition curriculum have shown that over 11 years, teaching diet and exercise did not do anything, in two age groups. One was elementary/middle school, another one was a high school group. And they found no changes in body size or nutritional knowledge and and only the effects of what they call weight stigma. Which is just anti-fat bias. So it only causes harm. And these meta studies were from “obesity researchers,” right? So they are even acknowledging we don't know how to prevent obesity.VirginiaSo you could see very clearly why the current landscape is harmful. How did you think about how to design a better curriculum?DeniseWe had been working on the back burner on an intuitive eating for students type of curriculum. Because the question I get from my teachers is, “What should I be teaching?” So we had been kind of working on an intuitive eating curriculum, and then one of my ambassadors, Selena Salfen, she works in Ramsey County Public Health in Minnesota, said, “Hey, we're looking for a nutrition curriculum. Why don't we do one together?”It really turned into how to eat, not what to eat. So we started working on body cues and building trust with your food. And then started really focusing on empowering the student as an authority on their own eating behavior, teaching them how to learn from their own eating experiences. Which is part of responsive feeding. And Ellyn Satter's Division of Responsibility In Feeding. So we have pieces from all of these. We are empowering students to be experts on their own eating.VirginiaIt's also so much more respectful of students' cultural backgrounds, as opposed to the way we learned, like the food pyramid or MyPlate, saying “this is what your plate should look like.” And that doesn't look like many plates around the world. That's not what dinner is in lots of families. Your curriculum is saying, let's empower students to be the experts is letting them own their own experience.DeniseAbsolutely, and trust their own experience. And trust themselves. And they don't have to go outside of themselves. We want to teach them to act in their own best interests. That's part of self-care, teaching them to take care of themselves. They need to learn it somewhere.So if you do what they've done for years and tell them you need to cut out sugar and you need to cut out carbs, or you need to get this this many grams of protein, it leaves off all of the wonderful parts of eating that we get to experience many times a day, which is the joy, the pleasure, the sharing of food. So in our curriculum, we ask the kids, what do you do in your culture around food? How do you celebrate in your culture with food? What do you eat?We get the discussion going with them and allowing them to feel pride in how their family celebrates. And so it's really bringing in all these other aspects that we experience with food every day into talking about food. And we talk about pleasure, what do you like, what food do you like, what food do you enjoy? And we want them to be able to hold what foods they like, what their needs are that day.So you talked about MyPlate, MyPlate is stagnant. It always looks the same. But your nutritional needs change every day. If I'm sick, my needs around nourishment are different from if I've got a soccer match after school that day. So we're trying to teach them to be flexible and really throw perfectionism out the window, because it's unhelpful in any area of life, but especially around eating, especially around food.VirginiaI'm wondering what you're hearing from school districts who are worrying about the federal guidelines. Because they do need to be in compliance with certain things. DeniseSo we spent a long time with the Food and Nutrition guidelines. The CDC food and nutrition guidelines, and we spent a long time with the HECAT standards, which are the health curriculum standards. We know that teachers are trying to match up what they're teaching to the federal standards and the state standards. Because every state has their own discussion of this, and they write their own rules. Usually they look like the federal standards, but we find with food and nutrition, sometimes they go off. You'll get somebody on the committee who hates soda, and will write 10 rules around soda. So every state has their own idiosyncratic rules around it as well.VirginiaI mean, on the flip side, that means there have been opportunities for advocacy. For example in Maryland, Sarah Ganginis was able to make real progress on her state standards. But yes, the downside is you're gonna have the anti-soda committee showing up.DeniseTotally. And half of the country. We really tried to hit the big standards. I'm actually thumbing through the curriculum right now. We have two pages of the HECAT model food nutrition lessons and which ones this curriculum hits. And then if you're interested in talking about some of the others — like some of them really want to talk about specifically sugary drinks— we give links in the curriculum to discussions that we agree with. So we may mention sugary drinks in a little piece of the curriculum, but if you want to get the article or the discussion on it that frames it the way we'd like to see it framed, we've got links in the curriculum for that.VirginiaSo tell me about the response so far. What are you hearing from teachers and districts?DeniseThe biggest response I'm getting is, “It's a breath of fresh air.” It's safe, as you say. And for the teachers out there that are familiar with all of the things that we've been teaching that haven't been working, this is important. And I just want to say to all the health teachers who have been teaching nutrition out there because this is the way we've taught it for years: This is how it's been done. But when you know better, you do better. And that's the point we're at now. I know people have been weighing and measuring kids and telling them to count calories for decades because that was best practices at the time. But we're beyond that. The research has figured out that that's not the best practices going forward.VirginiaThat's right.DeniseWe had about 50 teachers and 250 students trial it. We get the experts to say everything we want to say in the curriculum, and we put it in there, and then let's say that takes nine months. We have another nine months where we have expert teachers like Sarah weighing in on the curriculum. Telling us what happens when she teaches it in class with her and the students. What would you like to see different? Even down to activities. How would this activity work better? So we spent another nine months making sure that the teachers and the students like it, can relate to it, and that the activities are what are working in class.So that's an extra step after some of the other research curriculum that we really want to make sure it's user friendly and the students like it. We got a lot of feedback. We did two rounds of that.Now we released it to the public after we had a masters student write a thesis on all of the the data we collected, and felt very comfortable that it does no harm.VirginiaIt's been tested.DeniseYeah, it's been tested. It's feasible and acceptable. Now we're going to go and do the official feasibility and acceptability tests, like we've done on BodyKind with Let's Eat and then take it to schools. We use the University of North Carolina's IRB. We use the Mind Body Lab there, run by Dr. Jennifer Webb, and we are going to be doing research on Let's Eat. We've got the Portland Public Schools, and then we've got a school district in Maryland, in Arundel County, that we've identified and that we're working with to test students. And then, we'll hopefully do an official test, write an official paper, as we've done with BodyKind.VirginiaAnd I should also mention, you're making this resource free! Schools don't have to pay for this, which I think everyone who's ever tried to make any change in the school district of any kind knows, if it costs money, it's harder to get done. So that's great. DeniseYou know, it's so funny. I've been speaking on this for years. I mean, we've been in curriculum development for five years, and I always forget to say that! I don't know why. It's a free curriculum! I'm a nonprofit. I've never been paid. This is such a passion project for me, and I continue to wake up every day energized by the work I'm doing.And the mission of our nonprofit is to get the best, well tested resources out to schools. And we want to remove barriers. And how we remove barriers is offering it for free.VirginiaA lot of our listeners are parents. They're going to be listening to this thinking, “Okay, I want this in my kid's school.” How do we do that? What do you recommend parents do? DeniseSo a couple things. We find the best advocate is the person at the school, the wellness professional, charged with curriculum decisions. So there are people in your district whose job it is to make sure that the teachers have the latest and greatest curriculum on nutrition.And they want these resources because they want to make sure that their students get the best resources out there. So it takes a little bit of sleuthing to call up the school, whether it's the administrator or a health teacher, and figure out who's that person, who's the wellness coordinator. It could be a wellness coordinator. It could be a health teacher, who's responsible for curriculum. Find that person and talk to them. They're looking for this conversation. It's part of their job. You could even say I heard about this new curriculum. It's available for free. And you can hand them the postcard. That's what I hand out when I speak at conferences. And it's got a QR code. It describes what this curriculum does. We teach tuned in eating. It describes what tuned in eating does. VirginiaDownload that PDF above to QR code it right from this episode! DeniseYes. So you can send them as a PDF. You can write an email, figure out who the person is, send them the curriculum. Say “I was listening to a podcast, and there's this great curriculum out there. I'd love you to check it out.”VirginiaI think that feels really doable, it's a great starting point. What about when a kid comes home and tells a parent “Oh, we did calorie counting today?” Because that's often how parents start to think about this issue. It kind of lands on their lap. Is it useful to engage directly with the teacher? How do you think about that piece of it? Because obviously, especially the school year is underway, asking a teacher like, hey, can you just change your whole curriculum right on a dime, they probably won't appreciate that. So, what's a, better way to think about this advocacy?DeniseI thought you did a great job in your book Fat Talk on giving them scripts, giving parents scripts to walk into the school. You want to be sensitive to how overloaded the health teacher is, the nutrition teacher is. They're teaching 10 subjects in health that they need to be experts on so, you know, this is just one piece of what they're teaching.The great thing about nutrition is, most health teachers are teaching nutrition so they've got some background in it, and you can just be as sensitive as possible to their time and do as you say in the book, you know, in a in a positive, collaborative way. “I heard about this research, I thought you might be interested,” rather than a critical way. And and again, your kid might not be taking health, they might just be in the school district. So maybe you have this discussion with an administrator, and ask them, who wants to talk to me about this? And ask them, who can I speak to? It could be a guidance counselor. Could be school social worker. You know, this is eating disorder and body dissatisfaction prevention, right? So who, who is interested in this topic?VirginiaWho in the district is working on that and wants to know about this? That's super helpful.And I'll also add: One thing I learned in reporting the book and thinking more about the school issue is we do, as parents, always have the right to opt our kids out of the assignments that we know to be harmful. So if you see a calorie counting assignment coming, you can ask for an alternative assignment. You can accept that your kid might get a lower grade because they don't do it, but that might feel fair.Especially with older kids, I think it's important to involve them. Like, don't just swoop in. Never a good idea. They may want to talk to the teacher or you have do it. Work that out with your kid and figure out the best way forward. But I think it's definitely worth doing that. If your kid's like, no, don't talk to the teacher. No, I'm not opting out. You can still have the conversation at home about why this assignment is not aligned with your values, and that's yes important to do, too.DeniseI also wanted to say, we have an ambassador program at Be Real, and we have 135 ambassadors. What we've done with all of the materials we've been using for 10 years, which are presentations and worksheets for the presentations. We have frequently asked questions, where I quote you all the time. What do I do with my mother in law, who's saying this thing? We give them scripts. What do I do when people equate body size with health? What do we do when people assume that everyone could be small if they tried hard enough? We have answers for all of these questions in our materials, frequently asked questions.I have templated the presentations I give. I use the notes, I give the talk track, so my ambassadors can give a talk with a teleprompter if they're doing it on Zoom. Use the presentation as a teleprompter, and all the accompanying material we have on Canva that the ambassadors can create their own and add to it, and use their own name and picture to give talks and and things like that. We've got all of this so people are able to take this resource to their own local area,VirginiaSo they might give this talk to a PTA or a church group or any kind of community organization they're affiliated with.DeniseAbsolutely. And we've been doing this for about seven years, and the last five years, it's grown tremendously, and we have meetings every quarter. And at the meetings, people say, how do I get into my local school? And someone else will say, you know, I tried the principal and they didn't answer my phone calls. And then I went and looked up so and so and and then I started out doing this for professional development for health teachers in the state of Illinois. So we also have ways to to be certified as a professional development trainer on this topic. So that's how I initially got to health teachers. And then they also speak at conferences. So I speak at National SHAPE, which is the health teacher conference, but there are state SHAPE conferences out there that my Ambassadors will go speak at and it's really how to get all of this material, another way to get it disseminated all throughout the world.VirginiaOh, I love that. Well, we will definitely link in the show notes for anyone who's interested in becoming about an ambassador. ButterDeniseI am obsessed with Orna Guralnik, she is a psychotherapist who has a show on Showtime called Couples Therapy.VirginiaYes, I've been hearing about this.DeniseOh my God, it is so good. I don't know why I like it so much, but I just binge watched the new season. And I say every time, I've got to string it out and enjoy it, but no, it's impossible. And so I just binge watched the whole season, and as I was preparing for this interview, I just kept Googling what podcast she's been on.VirginiaThat's so satisfying. I love when you get a really good rabbit hole to dive down with the show. Another podcast I really enjoy, called Dire Straights , hosted by two writers, Amanda Montei and Tracy Clark-Flory, they just did an episode looking at the history of couples therapy and it actually has a pretty problematic history. Was not always great for women, very much developed as a way to help husbands control unruly wives—but has become other things. But you would enjoy that episode because they talk quite a bit about the show couples therapy and, she's obviously doing something quite different.DeniseOkay, that's my next one. Definitely going out and getting that.VirginiaI will also do a TV show butter, because they are so satisfying. I just started watching with my middle schooler a show that's been off the air for a few years now. It's called it's Better Things, starring Pamela Adlon and created by her. It's about a divorced mom with three daughters. She's a working actor in LA but it's just like about their life. It's very funny. It's very real and kind of gritty. My middle schooler and I have watched a lot of sitcoms together, and this is definitely a more adult show than we've watched before. But it's still a family show, and it's just, it's so so good. It's just a really incredible authentic portrayal of mothers and daughters. Which, you know, being a mother and a daughter, sometimes I'm like, is this making you like me more? Is this making you appreciate me? Probably not.DeniseHaving raised three kids, I don't aspire to that anymore.VirginiaNot the goal, not the goal.DeniseJust never going to show up.VirginiaBut it is really sweet bonding in a way that I hadn't expected. So that is my recommendation.DeniseLovely, lovely, lovely.VirginiaAll right, Denise. Tell folks again, just in case anyone missed it. Where do we find you? Where do we find the curriculums? How do we support your work?DeniseCome to berealusa.org—that's our website. We have more information on everything I've mentioned, on all of the curriculum, on how to become an ambassador, and just more explanation. On the website, we have fact sheets on everything we do. So if you go in, I think on the homepage, you drop down, they'll say fact sheets. And we also have probably have 10 fact sheets that will give you more information on this. We also talk about why you shouldn't be taking BMI school. We had a “don't weigh me in school” campaign about five years ago that kind of went viral. So anyway, that's all good on our website.The Burnt Toast Podcast is produced and hosted by Virginia Sole-Smith (follow me on Instagram) and Corinne Fay, who runs @SellTradePlus, and Big Undies.The Burnt Toast logo is by Deanna Lowe.Our theme music is by Farideh.Tommy Harron is our audio engineer.Thanks for listening and for supporting anti-diet, body liberation journalism! This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit virginiasolesmith.substack.com/subscribe

Budovanie rodinnej firmy a udržiavanie jej chodu aj po rokoch je jazda plná emócií, tradícií, ale aj generačných rozdielov. Anka s Naďou odhaľujú 6 skrytých sabotérov, ktorí brzdia rast rodinných podnikov – od nejasnej vízie, cez chýbajúci plán nástupníctva, až po emocionálne rozhodnutia, ktoré nahrádzajú tie biznisové. Na príkladoch z praxe ukážeme, ako môže stratégia zjednotiť rodinu aj biznis.V epizóde sa dozviete tiež:Ako postaviť rodinný biznis na pevných základoch.Prečo firme nestačí mať len dobrý produkt, ale potrebuje budovať silnú značku. Prečo sú jednotná vízia, značka a PR kľúčové aj v B2B segmente. Ako môže strategický marketing a plán nástupníctva vyriešiť generačné konflikty a posunúť firmu ďalej. Ak vás zaujímajú témy spojené s rodinnými podnikmi, vypočujte si aj náš podcast #225: Ako zvládnuť rozdielne očakávania v marketingu v rodinných podnikoch s Erikou Madari Matwij z Inštitútu rodinného biznisu (IRB). Bonusový materiál od Levosphere nájdete na našom Herohero. 

No episódio #80, recebemos Gustavo Kataguiri, gestor com mais de 20 anos de experiência no mercado financeiro, para falar sobre estratégias de total return, volatilidade da bolsa brasileira e oportunidades de investimento. Ele compartilha sua visão sobre alternância de poder no Brasil, cortes de juros, fluxo global de capitais e como isso impacta o mercado de ações. A conversa aborda também teses em bancos (Itaú, Banco do Brasil, bancos digitais), utilities (Copel), shoppings (Iguatemi) e até o polêmico IRB, além de reflexões sobre o uso de inteligência artificial na gestão de fundos. Se você quer entender onde estão as melhores oportunidades da bolsa, como gestores profissionais calibram risco e retorno e quais setores podem se destacar nos próximos anos, este episódio é imperdível.

Those with an understanding of Irish history will know the Irish Republican Brotherhood played a pivotal role in the country's politics from the late 19th century to the early 20th century. The IRB officially dissolved in 1924... or did they? An organisation claiming to be the IRB still exists today, and Crime and Security Correspondent with the Irish Times Conor Gallagher has been writing about their activities. Conor joins Séan to discuss.

Marty and Eric provide ideas and resources for your consideration is using project management softwareWhy move past email?Email buries decisions/files in long threads.Slack (real-time chat + threads) + a project manager (kanban/tasks/timelines) make work visible, searchable, and faster.Slack is already common in higher ed for communication and collaborative learning; pairing it with a project manager levels up coordination.30-minute starter kitCreate a Slack workspace; invite your class/research team with university emails.Channels (starter set): #announcements, #general-questions, #project-alpha, #helpdesk, #random.Norms (pin these in #announcements): use threads, tag with @, add short TL;DRs, react for quick status.Project manager: Set up a board with lists/columns → Backlog → To Do → Doing → Review → Done.Task template: Goal, owner, due date, checklist, attachments, link to reading/IRB doc.Connect Slack ↔ project manager: enable the integration so task updates post to the right channel.Teaching use casesTeam projects: each team gets a Slack channel + its own board; require weekly “Done” screenshots.Office hours: scheduled Slack huddles; post a recap thread.Peer feedback: students comment on tasks; instructor summarizes in Slack.Late-work transparency: a Blocked list with reason + next step.Research use casesProtocol to practice: one task per milestone (IRB, recruitment, analysis, manuscript).R&Rs: a “Review → Revise → Resubmit” lane with checklists for each reviewer note.Data hygiene: Slack for coordination only; store data in approved drives; link rather than upload.Accessibility & equityEncourage asynchronous participation; clear headings, short paragraphs, alt text for images.Prefer threads to reduce noise; summarize meetings in a single recap post.Privacy, policy, ethics (esp. counseling/education)No PHI/PII or client details in Slack or the project manager; share links to secured storage instead.Align with FERPA and IRB guidance; pin a “What NOT to post” note.Set channel/board permissions; remove access at term/project end; export/archive if required.Adoption playbook (4 weeks)Week 0: Announce tools + 5 rules (threads, TL;DRs, owners, due dates, recap posts).Week 1: Move announcements to Slack; first sprint (one deliverable on the board).Week 2: Turn on Slack↔PM automations; introduce the Blocked ritual.Week 3–4: Gather feedback; prune channels/labels; codify norms.Asana   Asana.com Free 10 members 3 projectsMonday   Monday.comOpenProject — https://www.openproject.org/ Pros: Full suite (Gantt, Agile boards, time tracking); mature docs; robust Community Edition. Cons: Heavier to administer; some advanced features gated to Enterprise. Taiga — https://taiga.io/ Pros: Clean Scrum/Kanban workflow; easy start; open source. Cons: Best fit for agile use—fewer “classic PM” features than larger suites. Redmine — https://www.redmine.org/ Pros: Very mature; flexible trackers/wiki; huge plugin ecosystem. Cons: Dated UI; Ruby stack setup can be fiddly. Leantime — https://leantime.io/ Pros: Designed for “non-project managers” (inclusive UX); simple boards/roadmaps; self-host downloads. Cons: Smaller ecosystem than Redmine/OpenProject. WeKan — https://wekan.fi/ Pros: Trello-style Kanban; easy install options (e.g., Snap); MIT-licensed. Cons: Kanban-only; limited built-in reporting. Kanboard — https://kanboard.org/ Pros: Ultra-light, minimal Kanban; quick self-host; solid docs. Cons: Project is in “maintenance mode”; fewer advanced features. Plane (Community Edition) — https://plane.so/ Pros: Modern UI; issues/sprints/roadmaps; AGPLv3 CE. Cons: Still evolving; smaller academic user base. Nextcloud Deck — https://apps.nextcloud.com/apps/deck Pros: Kanban tightly integrated with Nextcloud Files/Calendar; mobile apps available. Cons: Requires a Nextcloud instance; not a full PM suite.Email:ThePodTalkNetwork@gmail.comWebsite: ThePodTalk.Net

Those with an understanding of Irish history will know the Irish Republican Brotherhood played a pivotal role in the country's politics from the late 19th century to the early 20th century. The IRB officially dissolved in 1924... or did they? An organisation claiming to be the IRB still exists today, and Crime and Security Correspondent with the Irish Times Conor Gallagher has been writing about their activities. Conor joins Séan to discuss.

Cursaí polaitíochta an deireadh seachtaine - grúpa nua an IRB agus ceist na huachtaránachta.

For years the Irish Republican Brotherhood – the IRB – was remembered annually in a curious ceremony at Dublin's Mansion House when its self-styled president Billy McGuire conducted a ritual that involved turning a golden harp to reaffirm the sovereignty of Ireland.The existence of an IRB will come as a surprise to historians who consider that the secret-oath-bound society of the same name was disbanded more than 100 years ago.But in recent years, a new cohort has taken over the IRB name, turning it into a growing organisation steeped in the pseudo-legal language of the sovereign citizen movement, which believes citizens are not subject to State laws.This has caused officials in Dublin and nationally to become increasingly nervous about the group's intentions.The leaders of the modern IRB are in large part veterans of the Covid-19 anti-mask and anti-lockdown campaigns, along with property owners who turned to conspiracy theories after losing vast sums during the crash. Its leaders include a prominent Clare businessman, a teacher, a healthcare worker and a life coach.This version of the IRB has a shadow government, a nascent court system and a network of local government bodies. It has also adopted a new time zone, Irish Rising Time, which is 25 minutes slower and based on the time zone used in Dublin until the 1916 rising. It even claims control over Óglaigh na hÉireann.So is this fringe group like those harmless re-enactors who cosplay historical events or does it have the potential to go the way of some sovereign citizen groups in the US and Germany who have escalated their actions to include violence?Irish Times Crime and Security Correspondent Conor Gallagher explains.Presented by Bernice Harrison. Produced by Suzanne Brennan. Hosted on Acast. See acast.com/privacy for more information.

Cosmic Building, a construction technology company, uses AI-driven end-to-end software to run mobile robotic microfactories. At the heart of its newest microfactory in Pacific Palisades are ABB's IRB 6710 robots and RobotStudio digital twin software. Both of which are integrated into Cosmic's Workstation Cell and AI-driven Building Information Model (BIM). #ai   #california  #wildfire  #losangeles  #robot #fire

台師大女足抽血案新發展！7月29日，教育部指出，近日爆發爭議之「國科會精準運動科學研究計畫」研究計畫主持人陳忠慶、女足隊教練周台英，任教以來共29件研究案涉及血液樣本使用，下週將赴台師大、台大、北市大3校人體試驗委員會（IRB）擴大清查。 《報導者》在7月18日即獨家取得台師大研究倫理審查委員會針對「國科會精準運動科學研究計畫」的調查內容，挖出女足同時供血給不同研究案的內幕，揭露該研究計畫多個觸碰紅線的違規事實，同時訪問包括簡奇陞在內4名女足隊員，聽見抽血之外，真正讓她們在女足踢球不快樂的原因——教練跟不上時代的權威管教。 層層審查的把關機制中，為何仍然漏接了受試對象的權益？霸凌事實明確，教評會前後決定懲罰卻急轉彎，這又凸顯校內機制什麼問題？細觀這些抽血與訓練內容，其實也顯示體育升學制度中「絕對服從」的權力關係？ 目前，周教練因霸凌被解聘教職、被足協撤銷教練證，且恐面臨刑責，我國女足史上一代木蘭名將落得黯然退出結果⋯⋯這集，挖掘這則獨家報導的《報導者》副採訪主任嚴文廷、《少年報導者》總監楊惠君除分享獨家資料取得並揭露學術倫理缺失、師對生霸凌等問題的採訪幕後；也回望台灣女足曾經的百勝輝煌發展史，直指今日女足等體育專項教育急需更新的思維。 來賓｜《少年報導者》總監兼《報導者》編輯部顧問楊惠君、《報導者》副採訪主任嚴文廷 製作團隊｜詹婉如、陳思樺 攝影｜ 黃世澤

The 33 have been named. Last night in Upper Hutt the athletes charged with winning the World Cup were announced. 33 wāhine from across our fine motu were named as the Black Ferns to carry on New Zealand's outstanding record at the Women's Rugby World Cup. There were disappointments, notably the omission of one of the stars of the last tournament, the irrepressible Ruby Tui. I'm told Ruby was celebrating the loudest, cheering on the women picked, not sulking over her non selection. This says a lot to me about the sisterhood, the whanau, the strong bond between these women. And they'll need it. Back in the halcyon days, the Ferns were the gold standard. They dominated the game, winning six titles. The first two world tournaments, won by the USA and England, didn't have official recognition from the IRB (now World Rugby), but they have since been retrospectively given official status. In 1998 the Ferns became champions of the world. They have only been beaten once in the comp since then, and that was at the hands of England in 2014. Last time out they shook up the world at home, riding their luck past France in the semi then beating the English in a pulsating final at a chocka Eden Park. Joanah Ngan Woo was the hero that day, swiping a line out ball on her own line to stop the English surge in its tracks. An astonishing end to a spectacular tournament. The energy in the stadium was like nothing I have experienced in a big international rugby fixture. The testosterone that dominates All Black matches, the collective fear of defeat, the barely contained masculine rage didn't exist. It was pure joy. It was a rugby crowd as it should be. Let's hope that continues in England as New Zealand strut their stuff and win again. Not defend their title, win it all over again. See omnystudio.com/listener for privacy information.

In this episode of the MamasteFit Podcast, hosts Gina interviews Ryan Woodbury, one of the co-founders of the perinatal supplement support company, Needed. They discuss the importance of quality prenatal vitamins to fill nutritional gaps and support a healthy pregnancy. Ryan shares insights into her background, the inception of Needed, and the research and testing behind their prenatal vitamins. The conversation highlights the significance of bioavailable nutrient forms, the impact of iron absorption, and the importance of third-party testing to ensure product quality. Ryan addresses criticisms of 'designer prenatal vitamins' and emphasizes the value of investing in supplements that truly support maternal and fetal health. The episode underscores Needed's commitment to research and evidence-based nutritional solutions for the perinatal timeframe.Bio:Ryan Woodbury is the Co-founder and Co-CEO of Needed, a company championing radically better nutrition for women, their families, and our earth. She is a lifelong environmentalist, a holistic nutritionist with training in folk herbalism, and a mother of two children, and two rescue mutts.Links mentioned in this episode!  thisisneeded.com, neededacademy.com, and Needed's IRB study page thisisneeded.com/thrive00:00 Introduction to the Mama Safe Fit Podcast01:07 Meet Ryan from Needed01:43 Ryan's Background and Journey04:27 The Importance of Prenatal Nutrition08:18 Needed's Prenatal Vitamin Study20:36 The Science Behind Needed's Ingredients32:05 Addressing Controversies and Misconceptions41:08 Final Thoughts and Recommendations42:22 Testimonial and Conclusion————Get Your Copy of Training for Two on Amazon: https://amzn.to/3VOTdwH

台師大女足案最近新聞熱度很高，到底這是個政治議題？還是這個人體試驗哪裡出問題了？身為做臨床和動物實驗多年的 Angel 和若晴，帶你瞭解 IRB 是什麼，知情同意到底要怎麼達成，所謂權力不對等可能對受測者帶來的潛在傷害，一項一項分析給你聽！事件不該結束在道歉，而是要想想結構性的研究環境有沒有改善的空間。歡迎各方前輩給予指教和提出你的看法喔～ 工作人員 內容製作：Angel、若晴 後製：Angel 文案：Angel 音樂：雯薇 封面：雯薇 上架：Angel 宣傳：Angel、雯薇 -- Hosting provided by SoundOn

Send us a textWelcome back to Part Three of our Summer Series on Research 101! I'm once again joined by Chris Patty here in my recording closet. In Part One, we explored the history of research, Chris defined what research truly means, and we had some insightful discussions about nursing literature. An important takeaway from that episode was Chris's enthusiasm for AI and its potential in our field.In Part Two, we shifted our focus to developing the research protocol, particularly before presenting it to the Institutional Review Board (IRB). Chris helped demystify the IRB process, detailing its structure and what's needed for protocol approval. He also introduced the hierarchy of evidence, emphasizing its importance in the research landscape and reiterating how AI is influencing healthcare and nursing practices. If you missed those episodes, I highly recommend going back and giving them a listen!In this concluding episode, we tackled four crucial aspects of the research process: data collection, analysis, publication, and dissemination. After all, why invest so much effort in formulating your PICO question, facing the IRB, conducting your study, and collecting data, only to keep your findings to yourself? That would be quite insane!Before we wrapped up, I asked Chris why conducting research is so important, and his answer hit home, so be sure to listen for that.I'm a bit sad that our summer series is coming to an end. I've had such a rewarding time learning from Chris, and I hope you have too. Your feedback would be greatly appreciated, so feel free to share your thoughts! And don't forget to check out my CE Library at RNegade.Pro, because great news: this series qualifies for CE credits! The link is in the show notes. OrcidCureusContact The Conversing Nurse podcastInstagram: https://www.instagram.com/theconversingnursepodcast/Website: https://theconversingnursepodcast.comYour review is so important to this Indie podcaster! You can leave one here! https://theconversingnursepodcast.com/leave-me-a-reviewWould you like to be a guest on my podcast? Pitch me! https://theconversingnursepodcast.com/intake-formCheck out my guests' book recommendations! https://bookshop.org/shop/theconversingnursepodcast I've partnered with RNegade.pro! You can earn CE's just by listening to my podcast episodes! Check out my CE library here: https://rnegade.thinkific.com/collections/conversing-nurse-podcast Thanks for listening!

Send us a textWelcome back to the summer series, Research 101, this is Part Two. I'm once again joined in my closet by Chris Patty, and you may be wondering who I let in my closet, The answer would be only those closest to me and Chris is my brother, so he qualifies.Last week in Part One, we covered the history of research, what research really means, a little about nursing literature, and a lot about the incorporation of AI in our field. If you missed it, I highly recommend tuning in!In this episode, we delve into what comes next after formulating your PICO question—remember PICO stands for problem, intervention, comparison, and outcome. This question serves as the basis for your protocol when you present to the institutional review board, or the dreaded IRB, which can be a bit intimidating. Chris provides an insightful breakdown of the IRB's role, the key players involved, what's required in your protocol for approval, and the timeline for this process, which, as I learned, can sometimes depend on how fat your wallet is!One key highlight I enjoyed was Chris's discussion around evidence; he emphasized that the highest level of evidence comes from meta-analyses and systematic reviews, which sit at the top of the evidence hierarchy. Could the Framingham study be one of these? So many great gems in here!Don't forget to check out my CE Library at RNegade.Pro, because, good news: this series is eligible for CE credits! The link will be in the show notes. Here's Chris Patty.Contact The Conversing Nurse podcastInstagram: https://www.instagram.com/theconversingnursepodcast/Website: https://theconversingnursepodcast.comYour review is so important to this Indie podcaster! You can leave one here! https://theconversingnursepodcast.com/leave-me-a-reviewWould you like to be a guest on my podcast? Pitch me! https://theconversingnursepodcast.com/intake-formCheck out my guests' book recommendations! https://bookshop.org/shop/theconversingnursepodcast I've partnered with RNegade.pro! You can earn CE's just by listening to my podcast episodes! Check out my CE library here: https://rnegade.thinkific.com/collections/conversing-nurse-podcast Thanks for listening!

Eric Topol (00:05):Hello, it's Eric Topol from Ground Truths, and I've got some really exciting stuff to talk to you about today. And it's about the announcement for a new Center for pediatric CRISPR Cures. And I'm delight to introduce doctors Jennifer Doudna and Priscilla Chan. And so, first let me say this is amazing to see this thing going forward. It's an outgrowth of a New England Journal paper and monumental report on CRISPR in May. [See the below post for more context]Let me introduce first, Dr. Doudna. Jennifer is the Li Ka Shing Chancellor's Chair and a Professor in the departments of chemistry and of molecular and cell biology at the University of California Berkeley. She's also the subject of this book, one of my favorite books of all time, the Code Breaker. And as you know, the 2020 Nobel Prize laureate for her work in CRISPR-Cas9 genome editing, and she founded the Innovative Genomics Institute (IGI) back 10 years ago. So Jennifer, welcome.Jennifer Doudna (01:08):Thank you, Eric. Great to be here.Eric Topol (01:10):And now Dr. Priscilla Chan, who is the co-founder of the Chan Zuckerberg Initiative (CZI) that also was started back in 2015. So here we are, a decade later, these two leaders. She is a pediatrician having trained at UCSF and is committed to the initiative which has as its mission statement, “to make it possible to cure, prevent, and manage all diseases in this century.” So today we're going to talk about a step closer to that. Welcome, Priscilla.Priscilla Chan (01:44):Thank you. Thanks for having me.Eric Topol (01:46):Alright, so I thought we'd start off by, how did you two get together? Have you known each other for over this past decade since you both got all your things going?Jennifer Doudna (01:56):Yes, we have. We've known each other for a while. And of course, I've admired the progress at the CZI on fundamental science. I was an advisor very early on and I think actually that's how we got to know each other. Right, Priscilla?Priscilla Chan (02:11):Yeah, that's right. We got to know each other then. And we've been crisscrossing paths. And I personally remember the day you won the Nobel Prize. It was in the heart of the pandemic and a lot of celebrations were happening over Zoom. And I grabbed my then 5-year-old and got onto the UCSF celebration and I was like, look, this is happening. And it was really cool for me and for my daughter.Eric Topol (02:46):Well, it's pretty remarkable convergence leading up to today's announcement, but I know Priscilla, that you've been active in this rare disease space, you've had at CZI a Rare As One Project. Maybe you could tell us a bit about that.Priscilla Chan (03:01):Yeah, so at CZI, we work on basic science research, and I think that often surprises people because they know that I'm a pediatrician. And so, they often think, oh, you must work in healthcare or healthcare delivery. And we've actually chosen very intentionally to work in basic science research. In part because my training as a pediatrician at UCSF. As you both know, UCSF is a tertiary coronary care center where we see very unusual and rare cases of pediatric presentations. And it was there where I learned how little we knew about rare diseases and diseases in general and how powerful patients were. And that research was the pipeline for hope and for new discoveries for these families that often otherwise don't have very much access to treatments or cures. They have a PDF that maybe describes what their child has. And so, I decided to invest in basic science through CZI, but always saw the power of bringing rare disease patient cohorts. One, because if you've ever met a parent of a child with rare disease, they are a force to be reckoned with. Two, they can make research so much better due to their insights as patients and patient advocates. And I think they close the distance between basic science and impact in patients. And so, we've been working on that since 2019 and has been a passion of ours.Eric Topol (04:40):Wow, that's great. Now Jennifer, this IGI that you founded a decade ago, it's doing all kinds of things that are even well beyond rare diseases. We recently spoke, I know on Ground Truths about things as diverse as editing the gut microbiome in asthma and potentially someday Alzheimer's. But here you were very much involved at IGI with the baby KJ Muldoon. Maybe you could take us through this because this is such an extraordinary advance in the whole CRISPR Cures story.Jennifer Doudna (05:18):Yes, Eric. It's a very exciting story and we're very, very proud of the teamwork that went into making it possible to cure baby KJ of his very rare disease. And in brief, the story began back in August of last year when he was born with a metabolic disorder that prevented him from digesting protein, it's called a urea cycle disorder and rare, but extremely severe. And to the point where he was in the ICU and facing a very, very difficult prognosis. And so, fortunately his clinical team at Children's Hospital of Philadelphia (CHOP) reached out to Fyodor Urnov, who is the Director of Translational Medicine at the IGI here in the Bay Area. They teamed up and realized that they could quickly diagnose that child because we had an IRB approved here at the IGI that allowed us to collect patient samples and do diagnosis. So that was done.Jennifer Doudna (06:26):We created an off-the-shelf CRISPR therapy that would be targeted to the exact mutation that caused that young boy's disease. And then we worked with the FDA in Washington to make sure that we could very safely proceed with testing of that therapy initially in the lab and then ultimately in two different animal models. And then we opened a clinical trial that allowed that boy to be enrolled with, of course his parents' approval and for him to be dosed and the result was spectacular. And in fact, he was released from the hospital recently as a happy, healthy child, gaining lots of weight and looking very chunky. So it's really exciting.Eric Topol (07:16):It's so amazing. I don't think people necessarily grasp this. This timeline [see above] that we'll post with this is just mind boggling how you could, as you said Jennifer, in about six months to go from the birth and sequencing through cell specific cultures with the genome mutations through multiple experimental models with non-human primates even, looking at off-target effects, through the multiple FDA reviews and then dosing, cumulatively three dosing to save this baby's life. It really just amazing. Now that is a template. And before we go to this new Center, I just wanted to also mention not just the timeline of compression, which is unimaginable and the partnership that you've had at IGI with I guess Danaher to help manufacture, which is just another part of the story. But also the fact that you're not just even with CRISPR 1.0 as being used in approvals previously for sickle cell and β-thalassemia, but now we're talking about base editing in vivo in the body using mRNA delivery. So maybe you could comment on that, Jennifer.Jennifer Doudna (08:38):Yeah, very good point. So yeah, we used a version of CRISPR that was created by David Liu at the Broad Institute and published and available. And so, it was possible to create that, again, targeted to the exact mutation that caused baby KJ's disease. And fortunately, there was also an off-the-shelf way to deliver it because we had access to lipid nanoparticles that were developed for other purposes including vaccinations. And the type of disease that KJ suffered from is one that is treatable by editing cells in the liver, which is where the lipid nanoparticle naturally goes. So there were definitely some serendipity here, but it was amazing how all of these pieces were available. We just had to pull them together to create this therapy.Eric Topol (09:30):Yeah, no, it is amazing. So that I think is a great substrate for starting a new Center. And so, maybe back to you Priscilla, as to what your vision was when working with Jennifer and IGI to go through with this.Priscilla Chan (09:45):I think the thing that's incredibly exciting, you mentioned that at CZI our mission is to cure, prevent, and manage all disease. And when we talked about this 10 years ago, it felt like this far off idea, but every day it seems closer and closer. And I think the part that's super exciting about this is the direct connection between the basic science that's happening in CRISPR and the molecular and down to the nucleotide understanding of these mutations and the ability to correct them. And I think many of us, our imaginations have included this possibility, but it's very exciting that it has happened with baby KJ and CHOP. And we need to be able to do the work to understand how we can treat more patients this way, how to understand the obstacles, unblock them, streamline the process, bring down the cost, so that we better understand this pathway for treatment, as well as to increasingly democratize access to this type of platform. And so, our hope is to be able to do that. Take the work and inspiration that IGI and the team at CHOP have done and continue to push forward and to look at more cases, look at more organ systems. We're going to be looking in addition to the liver, at the bone marrow and the immune system.Priscilla Chan (11:17):And to be able to really work through more of the steps so that we can bring this to more families and patients.Eric Topol (11:30):Yeah, well it's pretty remarkable because here you have incurable ultra-rare diseases. If you can help these babies, just think of what this could do in a much broader context. I mean there a lot of common diseases have their roots with some of these very rare ones. So how do you see going forward, Jennifer, as to where you UC Berkeley, Gladstone, UCSF. I'm envious of you all up there in Northern California I have to say, will pull this off. How will you get the first similar case to KJ Muldoon going forward?Jennifer Doudna (12:13):Right. Well, IGI is a joint institute, as you probably know, Eric. So we were founded 10 years ago as a joint institute between UC Berkeley and UCSF. And now we have a third campus partner, UC Davis and we have the Gladstone Institute. So we've got an extraordinary group of clinicians and researchers that are coming together for this project and the Center to make it a success. We are building a clinical team at UCSF. We have several extraordinary leaders including Jennifer Puck and Chris Dvorak, and they are both going to be involved in identifying patients that could be enrolled in this program based on their diagnosis. And we will have a clinical advisory group that will help with that as well. So we'll be vetting patients probably right after we announce this, we're going to be looking to start enrolling people who might need this type of help.Eric Topol (13:18):Do you think it's possible to go any faster right now than the six months that it took for KJ?Jennifer Doudna (13:26):I think it could be. And here's the reason. There's a very interesting possibility that because of the type of technology that we're talking about with CRISPR, which fundamentally, and you and I have talked about this previously on your other podcast. But we've talked about the fact that it's a programmable technology and that means that we can change one aspect of it, one piece of it, which is a piece of a molecule called RNA that's able to direct CRISPR to the right sequence where we want to do editing and not change anything else about it. The protein, the CRISPR protein stays the same, the delivery vehicle stays the same, everything else stays the same. And so, we're working right now with FDA to get a platform designation for CRISPR that might allow streamlining of the testing process in some cases. So it'll obviously come down to the details of the disease, but we're hopeful that in the end it will be possible. And Priscilla and I have talked about this too, that as AI continues to advance and we get more and more information about rare diseases, we'll be able to predict accurately the effects of editing. And so, in some cases in the future it may be possible to streamline the testing process even further safely.Eric Topol (14:51):And I also would note, as you both know, well this administration is really keen on genome editing and they've had a joint announcement regarding their support. And in my discussions with the FDA commissioner, this is something they are very excited about. So the timing of the new Center for pediatric CRISPR Cures is aligned with the current administration, which is good to see. It's not always the case. Now going back, Priscilla, to your point that not just for the liver because delivery has been an issue of course, and we're going to try to get after a lot of these really rare diseases, it's going to go beyond there. So this is also an exciting new dimension of the Center, as you said, to go after the bone marrow for hematopoietic cells, perhaps other organs as well.Priscilla Chan (15:42):I mean what the expertise and feasibility, the immune system is going to be the next target. Jennifer Puck has been a pioneer in this work. She's the one who designed the newborn screen that will be the tool that picks up these patients as they are born. And I think the thing that's tremendous is the immune system, first of all is active in many, many diseases, not just these cases of children born with partial or absence of immune systems. And the course right now that these babies are left with is complete isolation and then a very long and arduous course of a bone marrow transplant with high morbidity and mortality. And even if after the transplant you have complications like graft versus host and immunosuppression. And so, the idea of being able to very specifically and with less the conditioning and morbidity and mortality of the treatment, being able to address this is incredible. And the implications for other diseases like blood cancers or other hematopoietic diseases, that's incredible. And that actually has an incredibly broad base of patients that can benefit from the learnings from these babies with severe combined immunodeficiencies.Eric Topol (17:10):Yeah, I think that goes back to a point earlier maybe to amplify in that previous CRISPR generation, it required outside the body work and it was extremely laborious and time consuming and obviously added much more to the expense because of hospitalization time. This is different. This is basically doing this inside the affected patient's body. And that is one of the biggest reasons why this is a big step forward and why we're so fortunate that your Center is moving forward. Maybe before we wrap up, you might want to comment, Jennifer on how you were able to bring in to build this platform, the manufacturing arm of it, because that seems to be yet another dimension that's helpful.Jennifer Doudna (18:01):Indeed, yes. And we were again fortunate with timing because you mentioned briefly that the IGI had set up a program with the Danaher Corporation back in January of last year. We call it our Beacon project. And it's focused on rare disease. And it's a really interesting kind of a unique partnership because Danaher is a manufacturing conglomerate. So they have companies that make molecules, they make proteins, they make RNA molecules, they make delivery molecules. And so, they were excited to be involved with us because they want to be a provider of these types of therapies in the future. And they can see the future of CRISPR is very exciting. It's expanding, growing area. And so, that agreement was in place already when the baby KJ case came to our attention. And so, what we're hoping to do with Danaher is again, work with them and their scientists to continue to ask, how can we reduce the cost of these therapies by reducing the cost of the molecules that are necessary, how to make them efficiently. We already, it's very interesting, Fyodor Urnov has toured their plant in North Dakota recently, and he found in talking to their engineers, there are a number of things that we can already see will be possible to do that are going to make the process of manufacturing these molecules faster and cheaper by a lot.Eric Topol (19:28):Wow.Jennifer Doudna (19:28):So it's a win-win for everybody. And so, we're really excited to do that in the context of this new Center.Eric Topol (19:36):Oh, that's phenomenal because some of these disorders you don't have that much time to work with before they could be brain or organ or vital tissue damage. So that's great to hear that. What you built here is the significance of it can't be under emphasized, I'll say because we have this May report of baby KJ, which could have been a one-off and it could have been years before we saw another cure of an ultra-rare disorder. And what you're doing here is insurance against that. You're going to have many more cracks at this. And I think this is the excitement about having a new dedicated Center. So just in closing, maybe some remarks from you Priscilla.Priscilla Chan (20:24):I just want to emphasize one point that's really exciting as we talk about these ultra-rare cases that they're often like one in a million. All these learnings actually help maximize the impact of lots of research across the sector that impacts actually everyone's health. And so, our learnings here from these patients that have very significant presentations that really can stand to benefit from any treatment is hopefully paving the way for many, many more of us to be able to live healthier, higher quality lives through basic science.Eric Topol (21:13):And over to you, Jennifer.Jennifer Doudna (21:15):Couldn't agree more. It's a really interesting moment. I think what we hope we are, is we're at sort of an inflection point where, as I mentioned earlier, all the pieces are in place to do this kind of therapeutic and we just need a team that will focus on doing it and pulling it together. And also learning from that process so that as Priscilla just said, we are ultimately able to use the same strategy for other diseases and potentially for diseases that affect lots of people. So it's exciting.Eric Topol (21:46):For sure. Now, if I could just sum up, this is now a decade past the origination of your work of CRISPR and how already at the first decade culminated in sickle cell disease treatment and β-thalassemia. Now we're into the second decade of CRISPR. And look what we've seen, something that was unimaginable until it actually happened and was reported just a little over a month ago. Now going back to Priscilla's point, we're talking about thousands of different rare Mendelian genomic disorders, thousands of them. And if you add them all up of rare diseases, we're talking about hundreds of millions of people affected around the world. So this is a foray into something much bigger, no less the fact that some of these rare mutations are shared by common diseases and approaches. So this really big stuff, congratulations to both of you and your organizations, the Innovative Genomics Institute and the Chan Zuckerberg Initiative for taking this on. We'll be following it with very deep interest, thank you.****************************************************Thanks for listening, reading and subscribing to Ground Truths.If you found this interesting PLEASE share it!That makes the work involved in putting these together especially worthwhile.Thanks to Scripps Research, and my producer, Jessica Nguyen, and Sinjun Balabanoff for video/audio support.All content on Ground Truths—its newsletters, analyses, and podcasts, are free, open-access.Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don't hesitate to post comments and give me feedback. Let me know topics that you would like to see covered.Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. Get full access to Ground Truths at erictopol.substack.com/subscribe

This week's episode I sat down with Ryan Woodbury, co-founder and co-CEO of one of our favourite supplement company's Needed who are championing radically better nutrition for women, their families and the earth. Ryan shared with us the shocking discoveries of Needed's IRB-approved clinical study, and that they found 95% of women were nutritionally depleted, even if they were taking a standard prenatal already. We chatted about the importance of tailored nutrition support, why we're seeing these nutrient deficiencies basically across the board in women, and how we can support women through fertility and pregnancy in a more well-rounded way.    You can read more about Needed's clinical study at thisisneeded.com/thrive or learn more about why this is important and how to help at neededacademy.com    Needed also has generously offered our podcast community 20% off their first order of supplements with the code DRKELSEY over at thisisneeded.com  Ready to lay the foundational groundwork to optimize your chances of getting pregnant, and include our partner in the process with research-driven support? Join our Conceive Together Challenge and walk away with both of your next steps! Check it out at ttc.kelseyduncan.com/ctchallenge

Pour cette deuxième émission enregistrée en marge du cinquième congrès mondial consacré à la drépanocytose, qui se tient à Abuja cette semaine, Priorité Santé propose un coup de projecteur sur les initiatives et programmes mis en œuvre en République Démocratique du Congo. La RDC est, après le Nigeria, le deuxième pays le plus touché par la maladie génétique de l'hémoglobine à l'échelle du continent africain. Depuis 2012, la fondation Pierre Fabre s'est engagée auprès des soignants, de la société civile et des autorités locales impliqués dans la lutte, pour améliorer dépistage et prise en charge des patients. Et nous donnons la parole à ces différents acteurs, pour évaluer les progrès et les défis à relever pour améliorer les conditions de vie des personnes drépanocytaires, et en particulier des enfants, en RDC. Cette émission est réalisée avec le soutien de la Fondation Pierre Fabre.  Nancy Madingo, infirmière du programme PAFOVED/CEFA-MONKOLE et au Centre de recherche IRB-one health dédiée à la drépanocytose Pr Léon Tshilolo, pédiatre hématologue, ancien médecin directeur du Centre hospitalier Monkole de Kinshasa, directeur de l'Institut de Recherche Biomédicale 1-Health, associé au CEFA-Monkole, président du REDAC (Réseau d'Étude de la Drépanocytose en Afrique Centrale) et Co-Chair de Sickle In Africa Consortium et Co-Chair du Veme Global SCD Meeting  Dr Patricia Fotto, médecin de santé publique et directrice du Programme national de lutte contre la drépanocytose, en RDC  Christophe Przybylski, directeur scientifique de la Fondation Pierre Fabre. Découvrez le programme de formation gratuit sur la drépanocytose : e-drépanocytose.  Programmation musicale : ► Inoss'B – Bango kaka te► Adekunle Gold – Sinner.

Pour cette deuxième émission enregistrée en marge du cinquième congrès mondial consacré à la drépanocytose, qui se tient à Abuja cette semaine, Priorité Santé propose un coup de projecteur sur les initiatives et programmes mis en œuvre en République Démocratique du Congo. La RDC est, après le Nigeria, le deuxième pays le plus touché par la maladie génétique de l'hémoglobine à l'échelle du continent africain. Depuis 2012, la fondation Pierre Fabre s'est engagée auprès des soignants, de la société civile et des autorités locales impliqués dans la lutte, pour améliorer dépistage et prise en charge des patients. Et nous donnons la parole à ces différents acteurs, pour évaluer les progrès et les défis à relever pour améliorer les conditions de vie des personnes drépanocytaires, et en particulier des enfants, en RDC. Cette émission est réalisée avec le soutien de la Fondation Pierre Fabre.  Nancy Madingo, infirmière du programme PAFOVED/CEFA-MONKOLE et au Centre de recherche IRB-one health dédiée à la drépanocytose Pr Léon Tshilolo, pédiatre hématologue, ancien médecin directeur du Centre hospitalier Monkole de Kinshasa, directeur de l'Institut de Recherche Biomédicale 1-Health, associé au CEFA-Monkole, président du REDAC (Réseau d'Étude de la Drépanocytose en Afrique Centrale) et Co-Chair de Sickle In Africa Consortium et Co-Chair du Veme Global SCD Meeting  Dr Patricia Fotto, médecin de santé publique et directrice du Programme national de lutte contre la drépanocytose, en RDC  Christophe Przybylski, directeur scientifique de la Fondation Pierre Fabre. Découvrez le programme de formation gratuit sur la drépanocytose : e-drépanocytose.  Programmation musicale : ► Inoss'B – Bango kaka te► Adekunle Gold – Sinner.

El envejecimiento es un proceso continuo y gradual que se inicia a nivel celular y molecular a partir de los 20 ó 30 años. Un estudio de del Instituto de Investigación Biomédica y del Centro de Regulación Genómica ha identificado modificaciones en el código genético relacionadas con el envejecimiento sanguíneo, un hallazgo que allana el camino para detectar enfermedades producidas por la vejez y el desarrollo de nuevas terapias para retrasar el envejecimiento en humanos. Hemos entrevistado a Alejo Rodríguez-Fraticelli, investigador ICREA en el IRB y co-autor del estudio.El pasado sábado, 31 de mayo, la Agencia Espacial Europea conmemoró el bicentenario del nacimiento de Johann Strauss II con un gran concierto en directo que fue transmitido a las estrellas mediante la antena de 35 m de espacio profundo de la ESA en Cebreros (Ávila). La celebración tuvo justo un día después del 50 aniversario de la firma de la Convención que dio lugar al nacimiento de la agencia espacial. Alda Olafsson nos ha informado del hallazgo de grandes concentraciones de microplásticos y micropartículas de caucho en poblaciones coralinas de Cladocora caespitosa en las Islas Columbretes, una reserva marina a 60 km de Castellón. Con testimonios de Diego Kersting, líder del trabajo en el Instituto de Acuicultura Torre de la Sal del CSIC. José Luis Trejo nos ha informado de un estudio en el que ha participado sobre los mecanismos neuronales que nos inducen al sedentarismo y las mejores estrategias para fomentar el ejercicio. Jesús Pérez Gil nos ha hablado de otro estudio, del que es coautor, sobre los poros de Kohn, espacios entre los alvéolos que permiten la comunicación y la redistribución del aire, y su papel en distribución del surfactante pulmonar, una sustancia compleja que evitado el colapso pulmonar y facilita el intercambio gaseoso. Adeline Marcos nos ha informado del proyecto europeo TEXTaiL. Empleará por primera vez tecnologías emergentes clave como la Inteligencia Artificial, la digitalización 3D, o los gemelos digitales, entre otros, para capturar y visualizar las características visibles y no visibles de los objetos arqueológicos textiles. Con testimonios de Aggelos Gkiokas, director de la empresa TechnAI y uno de los socios del proyecto.Escuchar audio

We hear why consumers should use the courts in preference to the IRB settlement mechanism for injury compensation. All to discuss with Sean Guerin SC, Chair of the Council of The Bar of Ireland.

OB/GYNs are entering the IVF space—but what role should they play?This debate is heating up in fertility medicine, and Dr. Stephanie Kuku, a former OB/GYN surgeon in the NHS and now Chief Knowledge Officer at Conceivable Life Sciences, offers her global, tech-forward perspectiveIn this episode, she talks through:What REIs and OB/GYNs really need from each otherWhere the line is on fertility care qualificationsWhat REI oversight could look like in different countriesHow new tech may expand REI roles (not replace them)How Conceivable is building collaborative care models (including their current 100-patient IRB study)The field is changing. How will REIs lead the way forward?

Doctor's Farmacy with Mark Hyman, MD: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Cutting-edge medical advances are unlocking new ways to slow aging and enhance health. Plasmapheresis removes harmful inflammatory molecules, toxins, and cellular waste from plasma, helping to reduce biological aging and improve resilience. Muse cells, a powerful form of stem cell therapy, show promise in regenerating tissue and treating complex conditions like ALS and stroke. And peptides—small, naturally occurring signaling molecules—support healing, immune balance, and cellular repair, offering practical tools for longevity and optimized health. In this episode, I talk with Dr. Darshan Shah, Dr. Adeel Khan, and Dr. Edwin Lee about medical advancements that are the ultimate longevity biohacks. Dr. Darshan Shah is a board-certified surgeon, longevity medicine expert, author, and founder of Next Health—the world's largest Health Optimization and Longevity clinic. He has performed over 20,000 surgical procedures and advised thousands on extending healthspan and lifespan. A prodigy in medicine, Dr. Shah earned his MD at 21 and trained at the Mayo Clinic. He has since launched multiple health ventures, authored a book, and patented medical devices. Committed to ongoing learning, he holds alumni status at Harvard Business School and Singularity University. Dr. Shah is a sought-after speaker on health and longevity. Dr. Adeel Khan, M.D. is a cell and gene therapy specialist with a visionary approach that is changing the way we perceive healthcare worldwide. Khan has cemented his reputation as a regenerative medicine expert and a driven entrepreneur. Dr. Edwin Lee is a board-certified endocrinologist, author, and international speaker specializing in hormonal balance, regenerative, and functional medicine. He founded the Institute for Hormonal Balance in Orlando in 2008 and completed fellowships in Critical Care and Endocrinology at the University of Pittsburgh. Dr. Lee is the lead investigator of an IRB-approved senolytic study exploring compounds like Dasatinib, Quercetin, and Fisetin, and recently published the first human trial using BPC157 for knee pain. He is an assistant professor at the University of Central Florida College of Medicine, co-founder of the Clinical Peptide Society, and founder of SavePeptides.org. His latest book is The Fountain of Youth with Peptides. This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN10 to save 10%. Full-length episodes can be found here: This Breakthrough Blood Therapy Could Add Years To Your LifeStem Cells & Peptides: The Secret to Reversing Chronic Pain and Aging?How Peptides Enhance Healing and Longevity

Cutting-edge medical advances are unlocking new ways to slow aging and enhance health. Plasmapheresis removes harmful inflammatory molecules, toxins, and cellular waste from plasma, helping to reduce biological aging and improve resilience. Muse cells, a powerful form of stem cell therapy, show promise in regenerating tissue and treating complex conditions like ALS and stroke. And peptides—small, naturally occurring signaling molecules—support healing, immune balance, and cellular repair, offering practical tools for longevity and optimized health. In this episode, I talk with Dr. Darshan Shah, Dr. Adeel Khan, and Dr. Edwin Lee about medical advancements that are the ultimate longevity biohacks. Dr. Darshan Shah is a board-certified surgeon, longevity medicine expert, author, and founder of Next Health—the world's largest Health Optimization and Longevity clinic. He has performed over 20,000 surgical procedures and advised thousands on extending healthspan and lifespan. A prodigy in medicine, Dr. Shah earned his MD at 21 and trained at the Mayo Clinic. He has since launched multiple health ventures, authored a book, and patented medical devices. Committed to ongoing learning, he holds alumni status at Harvard Business School and Singularity University. Dr. Shah is a sought-after speaker on health and longevity. Dr. Adeel Khan, M.D. is a cell and gene therapy specialist with a visionary approach that is changing the way we perceive healthcare worldwide. Khan has cemented his reputation as a regenerative medicine expert and a driven entrepreneur. Dr. Edwin Lee is a board-certified endocrinologist, author, and international speaker specializing in hormonal balance, regenerative, and functional medicine. He founded the Institute for Hormonal Balance in Orlando in 2008 and completed fellowships in Critical Care and Endocrinology at the University of Pittsburgh. Dr. Lee is the lead investigator of an IRB-approved senolytic study exploring compounds like Dasatinib, Quercetin, and Fisetin, and recently published the first human trial using BPC157 for knee pain. He is an assistant professor at the University of Central Florida College of Medicine, co-founder of the Clinical Peptide Society, and founder of SavePeptides.org. His latest book is The Fountain of Youth with Peptides. This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN10 to save 10%. Full-length episodes can be found here: This Breakthrough Blood Therapy Could Add Years To Your LifeStem Cells & Peptides: The Secret to Reversing Chronic Pain and Aging?How Peptides Enhance Healing and Longevity

Atenção (disclaimer): Os dados aqui apresentados representam minha opinião pessoal.Não são de forma alguma indicações de compra ou venda de ativos no mercado financeiro.IPCA-15: Inflação sobe 0,43% em abril e acumula alta de 5,49% em 12 meseshttps://www.moneytimes.com.br/ipca-15-previa-inflacao-abril-2025-visp/CSN avança contra IRB na Justiça e pede mais do que vale a companhiahttps://www1.folha.uol.com.br/colunas/painelsa/2025/04/csn-avanca-contra-irb-na-justica-e-pede-mais-do-que-vale-a-companhia.shtmlNeoenergia (NEOE3) vende 50% da Itabapoana Transmissão de Energiahttps://financenews.com.br/2025/04/neoenergia-neoe3-vende-50-da-itabapoana-transmissao-de-energia/OPA do Carrefour (CRFB3): de ‘virada', acionistas aprovam saída da empresa da bolsa brasileirahttps://www.seudinheiro.com/2025/empresas/opa-do-carrefour-crfb3-de-virada-acionistas-aprovam-saida-da-empresa-da-bolsa-brasileira-mabe/Família Dubrule chama de "chicana" acusação da Toky e mantém OPAhttps://pipelinevalor.globo.com/negocios/noticia/familia-dubrule-rebate-chicana-da-toky-e-mantem-opa.ghtmlA disputa pela Toky escala e chega ao Cade e à Justiçahttps://neofeed.com.br/negocios/a-disputa-pela-toky-escala-e-chega-ao-cade-e-a-justica/EXCLUSIVO: Transformação da Casas Bahia está quase na metade, diz CEOhttps://www.infomoney.com.br/business/exclusivo-transformacao-da-casas-bahia-esta-quase-na-metade-diz-ceo/Azul (AZUL4) levanta R$ 1,66 bilhão em oferta de açõeshttps://www.moneytimes.com.br/azul-azul4-levanta-r-166-bilhao-em-oferta-de-acoes-lmrs/XP comunica vazamento de dados de clientes e faz alerta para contatos suspeitoshttps://www1.folha.uol.com.br/mercado/2025/04/xp-comunica-vazamento-de-dados-de-clientes-e-faz-alerta-para-contatos-suspeitos.shtmlNúmero de passageiros transportados da Azul cresce 9,3% no 1º tri ante 1º tri de 2024https://istoedinheiro.com.br/numero-de-passageiros-transportados-da-azul-cresce-93-no-1o-tri-ante-1o-tri-de-2024-2/Special Coverage from Marketplace: Selling Americahttps://podcasts.apple.com/br/podcast/special-coverage-from-marketplace-selling-america/id201853034?i=1000704227996What the U.S. is offering and demanding in latest Ukraine ceasefire proposalhttps://podcasts.apple.com/br/podcast/what-the-u-s-is-offering-and-demanding-in-latest/id78304589?i=1000704652262What an Iowa Farmer Fears About the Trade Warhttps://podcasts.apple.com/br/podcast/what-an-iowa-farmer-fears-about-the-trade-war/id1200361736?i=1000704713254

Dean's Chat hosts, Drs. Jensen and Richey, welcome Dr. Gerit D. Mulder to the podcast!  Dr. Mulder gave Dr. Jensen an opportunity to join his practice at the Wound Healing Institute after residency, providing a tremendous foundation for future research that included the National Institutes of Health, and Department of Defense opportunities.  Dr. Mulder has a storied history in podiatric medical research in the wound care space.  He received his BS at University of Redlands; a masters degree from Cal State - San Bernadino, then received his DPM from the College of Podiatric Medicine. He received his PhD from Chulalongkorn University through University of California San Diego specializing in Biomedical Sciences/Stem Cells.  Gerit speaks 5 languages and has taught wound care, and implemented wound care programs around the world.  Tune in for a fabulous interview! Below is a brief history of Dr. Mulder's activities and qualifications: • Extensive expertise in the development, implementation and management of clinical trials, clinical operations and teams.  Experience as a lead Principal Investigator interacting with and guiding multicenter trials.  Direct interaction with the FDA, Pharmaceutical Industry and Academic Research Centers.  Focus on Inflammatory Diseases, Dermatology and Infectious Disease.  • Responsible for development and oversight than 120 clinical trials. • Supervised, educated, and guided research teams globally. • Developed project budgets, protocols, guidelines, and implementation plans for developing wound clinics. • Provided strategic and tactical input to the medical industry related to clinical trials with emphasis on Phase 1,2 and 3 studies.  • Created tissue and wound repair programs to increase product understanding to assist Emerging Markets. Additional Expertise and Affiliations Include: • Understanding of Regulatory Affairs. • International experience with monitoring and overseeing clinical trials. • Served as a national and international  • Provided input on new product development for novel disease states.  • Conversational skills in English, Spanish, Italian, French, and German • Extensive experience with KOLs and medical advisory boards. Physician at Christus St. Vincent Medical Center, Wound & Hyperbaric Center. December 2021 to current. • Provide advanced clinical care for chronic wounds of all etiologies including diabetic, venous, pressure, trauma and other wounds. • Direct wound and tissue repair and regeneration research Medical Research Consultant – Independent 2019 – current Clinical Tissue Repair and Regeneration Specialist – 2019-current • Consult internationally on Phase 1,2, and 3 clinical trials • Provide input for development and implementation of clinical trials and educational materials for health care providers related to phase 1, 2 and 3 studies as well as approved products. • Provide clinical care to patients with acute and chronic wounds of all etiologies Director, Professor of Surgery and Orthopedics University of California San Diego Medical Center, Wound Treatment and Research Center   April 1998- December 2013 •  Provided clinical and surgical care, conducted medical student, resident and staff education, oversaw clinical research.  Treated more than 3000 patients per year.  Published in peer reviewed medical journals and key presenter at medical conferences globally. • Oversaw research within my division of the Department of Trauma, with focus on tissue regeneration and repair, inflammatory and infectious related diseases and cell regeneration. June 1986-April 1998: President of WCI (Wound Consultants Inc., previously Wound Healing Institute)    WCI offered consulting services to the biotechnology and pharmaceutical industry related to clinical protocols and trials, implementation of related patient care, planning and managing medical education.  Advised on development of new products related to tissue regeneration and repair. Patient Care    Vice President of Marketing and Medical Affairs DermaRx  May 1995- March 1998 Vice President of Clinical and Regulatory Affairs Organogenesis, Inc.   May 1994-May 1995     Wound Clinic Director Veterans Administration Hospital Denver June 1983- Jne 1992 FDA Experience: • Participated as an advisor to the FDA and companies working with the FDA • Completed and submitted 510k for hydrogel, foam, and other wound treatment devices • Completed clinical section of PMA submission on Apligraf for Organogenesis • Consulted as wound care expert on panels for medical and pharmaceutical industry. • Chaired Human Subjects Committee in Denver for two years for a major IRB. • Interacted with FDA on Dermatology and Inflammatory Diesease Dr. Mulder can be reached at (619) 417-9249 or at gerit.mulder@gmail.com;  gerit.mulder@stvin.org  or on LinkedIn at http://www.linkedin.com/pub/gerit-mulder/a/321/6b5

In this episode, Edye Edens and Darshan Kulkarni discuss the evolving landscape of IRB oversight in 2024, including the roles of HRPP, AAHRPP, and OHRP, and the need for greater federal agency involvement. They also cover the impact of new guidance, the Trump administration, and the FDA's relationship with IRBs.We discuss: 1. The FDA's Finalized Guidance on Decentralized Clinical Trials (DCTs): The recent FDA guidance formalizing decentralized elements in clinical trials raises critical questions for Institutional Review Boards (IRBs). While DCTs have existed for years, the official guidance now provides a framework for utilizing healthcare providers (HCPs), remote modalities, and flexible patient engagement. IRBs must consider:Approval Implications: How decentralized elements affect risk-based assessments and informed consent.Data Validity: Whether varying patient experiences impact trial control and data integrity.Protocol Design: Increased complexities in evaluating sponsor protocols that integrate hybrid or decentralized approaches.2. Human Research Protection Programs (HRPPs): IRBs are components of broader HRPPs, which also encompass research compliance, conflict of interest management, and quality auditing. Accreditation bodies like AAHRPP (gold standard for HRPPs) demand higher standards, which could necessitate additional adjustments to align with FDA guidance.3. Regulatory Overlap and Harmonization Challenges: IRBs must navigate overlapping jurisdiction from the FDA and other entities like the Office for Human Research Protections (OHRP). The lack of harmonized regulations between these agencies creates confusion for researchers and inefficiencies in clinical trial oversight.4. FDA Audits and Oversight of IRBs: While the FDA does not directly regulate IRBs, it audits them and issues warning letters or Form 483 observations. IRBs must remain vigilant about FDA compliance, especially with decentralized elements becoming more common.5. Decentralization's Efficiency Debate: There is no blanket conclusion about whether decentralized trials increase efficiency or diversity. IRBs must assess the appropriateness of decentralized approaches on a case-by-case basis, particularly for complex studies like oncology trials or early-phase research requiring hospital stays.6. Calls for Streamlining Oversight: There is growing discussion about reducing redundancy across regulatory bodies to enhance efficiency and lower costs for patients. However, skepticism remains about whether eliminating overlap would ensure adequate protection for trial participants.7. Future Considerations:Adaptation: IRBs must adapt to increased DCT submissions while maintaining rigorous risk-based evaluations.Consistency: Balancing flexibility in decentralized models with the need for consistent oversight practices.Policy Evolution: Ongoing dialogue on whether accrediting bodies like AAHRPP or agencies like OHRP should develop complementary guidance to align with FDA standards.In 2024, IRBs face a critical moment to address these challenges while ensuring that decentralized innovations do not compromise participant safety or trial integrity.Support the show

Patrick Geoghegan chats to Prof Diarmaid Ferriter on how Ireland was transformed over the past 25 years, as told in his new book The Revelation of Ireland, 1995-2020; we also hear the untold story of the women on Wall Street and the misogyny they faced, from Paulina Bren's new book She Wolves: The Untold History of Women on Wall Street; and how the IRB changed the course of Irish history, with John O'Beirne Ranelagh.

Send us a text - your number will not show, so if you want a response include an emailIn episode #138, I chat with Dr. Todd Fiore about how one slight pivot with your research question can lead to many positive outcomes. Todd is the Program Chair for the PhD in Organizational Development and Leadership, University of Arizona Global Campus.Highlights:·  Research framed positively tends to result in more practical, solutions-oriented outcomes.·  Positive research questions make it easier to recruit participants and encourage openness in data collection because participants may be more willing to engage when research focuses on positive practices rather than negative issues.·  A positive approach can reduce challenges with IRB approval, particularly for sensitive topics like trauma.·  Reframing helps novice researchers avoid injecting personal bias into their work - the dissertation is an academic product, not an advocacy project, and should be balanced and unbiased.·  Focusing solely on problems in research can lead to emotional burnout; positive framing keeps the research journey lighter.·  “Once you replace negative thoughts with positive ones, you'll start having positive results” – a guiding philosophy for research success.Other episodes you don't want to miss:The Dissertation Shift with Dr. Todd Fiore  The 4 H's of Doctoral Success with Dr. Todd FioreHow to Get a Job Teaching Online with Dr. Todd Fiore  You might also enjoy: The Best Dissertation is a DONE Dissertation with Dr. Melanie ShawAcademic Writing as if Readers Matter with Dr. Len CassutoYES!! Keep on creating! https://www.expandyourhappy.com/offers/f9BCgMfF/checkoutSupport the showSupport this free content: https://www.buzzsprout.com/1547113/supporters/new Get The Happy Doc Student Handbook: https://www.amazon.com/dp/0578333732Other resources at: http://Expandyourhappy.com Want to make my day? Rate, review, subscribe & share with someone you love.

What drives a seasoned developer from Taiwan to London, and how does one translate a passion for Ruby into groundbreaking projects? Hear from Stan Lo of Shopify's RubyDX team as he shares his captivating journey and his significant impact on the Ruby development landscape. From his essential work on the debug gem and IRB to his current efforts with the Sorbet type checker and Prism parser, Stan delves into the technical intricacies of using C++ for performance and memory management. Gain unique insights into the collaborative decision-making process at Shopify that guided his transition from the Ruby LSP to focusing on Sorbet's integration.We also tackle the hurdles of progressing Ruby's Sorbet parser to Prism and the challenges of maintaining comprehensive Ruby documentation. Discover the importance of community-driven contributions, and how small acts like fixing typos can have a profound impact on the Ruby ecosystem. Experience Stan's personal anecdotes, from climbing adventures to mastering calisthenics, and explore the innovative shift from VS Code to Cursor, amplifying his development experience through AI capabilities. As we gear up for future events like RailsConf and RubyKaigi, there's an air of excitement for community reunions and ongoing projects. Join us for a blend of technical discussion, personal stories, and a call to action for all Ruby enthusiasts.Send us some love.HoneybadgerHoneybadger is an application health monitoring tool built by developers for developers.HoneybadgerHoneybadger is an application health monitoring tool built by developers for developers.Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showReady to start your own podcast?This show is hosted on Buzzsprout and it's awesome, not to mention a Ruby on Rails application. Let Buzzsprout know we sent you and you'll get a $20 Amazon gift card if you sign up for a paid plan, and it helps support our show.

"Dr. Molly Maloof has made it her mission to inspire people to make the right choices and design their unique lifestyle to improve their wellbeing, avoid chronic disease, and radically extend their health span—the length of time in one's life where one is in optimal health free from injury and illness. She believes that lifestyle medicine and personal health technologies will shape the future of health care because they are designed to help individuals achieve the true definition of health: “The ability to adapt and to self-manage, in the face of social, physical and emotional challenges.” The goal is for individuals to move towards physical, mental and social well-being, and not merely the absence of disease and infirmary." Dr. Molly is here today to discuss a range of topics, such as: *relationships and their effect on longevity and healthspan*the relationship between metabolic health and relational health*their latest IRB-approved study to understand the efficacy of our groundbreaking program, the Adamo Method. Order her new book “The Spark Factor” - a breakthrough program for women to revive their lost energy and vitality, developed by a leading biohacker and physician. https://drmolly.co/