Podcasts about bioid

Assessoria esportiva online e presencial: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.leandrotwin.com.br/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ E-book Dieta Inteligente - Para Perder Gordura e Ganhar Massa Muscular só R$ 39,90: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://pay.hotmart.com/T77984348A?checkoutMode=10⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Curso de Dieta (Monte a sua dieta ainda hoje): ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://pay.hotmart.com/G56713152F?checkoutMode=10⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Curso de Treino (Como montar seu treino periodizado): ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://pay.hotmart.com/U72090251V?checkoutMode=10⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Curso Sobre Esteroides Anabolizantes (Não use esteroides antes de fazer este curso): ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://pay.hotmart.com/T64303539E?checkoutMode=10⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Curso de Suplementação para Praticantes de Musculação: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hotmart.com/pt-br/club/public/leandro-twin-cursos⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Grupo do Telegram para promoções de todos os meus produtos: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://t.me/leandrotwin⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/leandrotwin/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/oficialleandrotwin?ref=hl⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Este vídeo é um oferecimento de: Oficial Farma: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.oficialfarma.com.br/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Growth Supplements:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.gsuplementos.com.br⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Atenção: As mensagens contidas em todos os vídeos de LeandroTwin não possuem o objetivo de substituir orientação de um profissional (independente da sua área de atuação). O vídeo é informativo. Qualquer rotina iniciada por conta própria é de responsabilidade do próprio.

SUSCRÍBETE A LA VERSIÓN DE PAGO DE LA NEWSLETTER PARA RECIBIR CONTENIDO EXCLUSIVO SUSCRIBETE A LA VERSIÓN EN ABIERTO DE LA NEWSLETTER A MICRÓFONO CERRADOTODAS LAS NOTAS DEL EPISODIO EN WWW.CRISTINAMITRE.COMTerapia hormonal sustitutiva, hormonas bioidénticas… ¡resolvemos dudas! Aquí hay mucha tela que cortar y aunque es un tema del que, afortunadamente, cada vez hablamos más, también es cierto que abunda la desinformación. Gracias a Melagyn de Gynea pudimos despejar muchísimas dudas en du directo en Instagram con la ginecóloga Sonia Sánchez. Lo he reconvertido en episodio especial para que lo tengáis disponible en el podcast.Si te dijera que hay un gel de higiene íntima que repara, protege y calma la piel, cuyo efecto dura hasta la siguiente aplicación, y que además te proporciona una sensación estupenda de frescor, confort y suavidad, ¿verdad que querrías saber cuál es? Pues eso es lo que aporta a la piel de la zona íntima Melagyn Gel de Gynea.Una vez al día, en la ducha, puedes hacer mucho para cuidar la piel de la zona genital, un área que, por su mayor humedad y exposición a gérmenes, requiere cuidados específicos para mantener su higiene, sentirnos a gusto y protegernos de infecciones. Por eso, utilizar un producto específico, como Melagyn Gel de Gynea, es parte de una buena rutina de autocuidado. Melagyn Gel de Gynea ha sido especialmente diseñado para la piel de la delicada zona genital. Está formulado a base de aceite de árbol del té y con un pH ligeramente alcalino, para mantener el pH vulvar dentro de sus valores fisiológicos. Ahora lo tienes disponible en un nuevo formato de 500 ml con dosificador. Pregunta en tu farmacia para conocer más sobre Melagyn Gel de Gynea y toda la gama Melagyn.Instagram @thebeautymailTwitter @cristinamitreYouTube https://www.youtube.com/c/CristinaMitreLinkedIn Cristina Mitre ArandaFacebook https://www.facebook.com/Crismitre Hosted on Acast. See acast.com/privacy for more information.

The wild west of biometrics  Can a deepfake really steal your identity? Ann-Kathrin Freiberg, Manager Business Development and Marketing at BioID, pulls back the curtain on some of the most common misconceptions around biometrics and explains why new attack vectors should be managed, not feared.  CREDITS   Host: Blair Crawford, Co-founder and CEO, Daltrey  Guests: Ann-Kathrin Freiberg Manager Business Development and Marketing at BioIDProducer: RadioHub Podcast Productions    LIKED THIS EPISODE? PLEASE RATE AND REVIEW See omnystudio.com/listener for privacy information.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.26.549647v1?rss=1 Authors: Carmona, B., Camelo, C., Mehraz, M., Lemullois, M., Lince-Faria, M., Coyaud, E., Marinho, H. S., Goncalves, J., Nolasco, S., Pinto, F., Raught, B., Tassin, A.-M., Koll, F., Soares, H. Abstract: Centrosomes are organelles consisting of two structurally and functionally distinct centrioles, with the mother centriole having complex distal (DA) and subdistal appendages (SDA). Despite their importance, how appendages are assembled and maintained remains unclear. This study investigated human TBCCD1, a centrosomal protein essential for centrosome positioning, to uncover its localization and role at centrioles. We found that TBCCD1 localizes at both proximal and distal regions of the two centrioles, forming a complex structure spanning from SDA to DA and extending inside and outside the centriole lumen. TBCCD1 depletion caused centrosome mispositioning, which was partially rescued by taxol, and the loss of microtubules (MTs) anchored to centrosomes. TBCCD1 depletion also reduced levels of SDA proteins involved in MT anchoring such as Centriolin/CEP110, Ninein, and CEP170. Additionally, TBCCD1 was essential for the correct positioning of motile cilia basal bodies and associated structures in Paramecium. This study reveals that TBCCD1 is an evolutionarily conserved protein essential for centriole and basal body localization and appendage assembly and maintenance. A BioID screening also linked TBCCD1 to ciliopathy-associated protein networks. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.27.546694v1?rss=1 Authors: Bedir, M., Outwin, E., Colnaghi, R., Bassett, L., Abramowicz, I., O'Driscoll, M. Abstract: We previously reported that non-homologous end-joining (NHEJ)-defective human LIG4-/- pre-B lymphocytes were unexpectedly sensitive to killing by the cyclic peptide Cyclosporin A (CsA), a common component of bone marrow transplantation conditioning and maintenance regimes. We also found that CsA induced DNA double strand breaks (DSBs) in LIG4 syndrome patient fibroblasts, specifically upon transit through S-phase. The molecular basis underlying these CsA impacts has not been described hitherto. We postulated that CsA-induced genomic instability may reflect a direct role of Cyclophilin A (CYPA) in DNA repair, as CYPA is the primary physiological target interactor of CsA. CYPA is the founding member of the Cyclophilin family of peptidyl-prolyl cis-trans isomerases (PPIs). CsA inhibits the PPI activity of CYPA through occupation of the latters enzymatic active site. Using an integrated approach involving CRISPR/Cas9-engineering, siRNA, BioID, co-immunoprecipitation, pathway-specific DNA repair investigations as well as protein expression-interaction analysis, we describe novel impacts of CYPA loss and inhibition of its PPI activity on DNA repair. Prompted by findings from our CYPA-BioID proximity interactome, we validate CYPA interactions with different components of the DNA end resection machinery. Moreover, we characterise a novel and direct CYPA interaction with the NBS1 component of the MRE11-RAD50-NBS1 (MRN) complex, providing evidence that the PPI function of CYPA actively influences DNA repair via direct protein-protein interaction at the level of DNA end resection. Consequently, we demonstrate that CYPA loss or inhibition impairs Homologous Recombination Repair (HRR) following DNA replication fork stalling. Additionally, we define a set of genetic vulnerabilities associated with CYPA loss and inhibition, identifying DNA replication fork protection as an important determinant of viability herein. Leveraging the novel insights into CYPA biology we have uncovered; we explore examples of how CYPA PPI inhibition may be exploited to selectively kill cells from a variety of different cancers with a shared characteristic genomic instability profile. These findings propose a potential new disease application or repurposing strategy for the non-immunosuppressive CsA analogue class of Cyclophilin inhibitors. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.21.545954v1?rss=1 Authors: Thompson, J., Boisvert, F.-M., Salsman, J., Dellaire, G., Ridgway, N. D. Abstract: When exposed to excess fatty acids, specific cell types produce nuclear lipid droplets (nLDs) that associate with promyelocytic leukemia (PML) protein to form Lipid Associated PML Structures (LAPS) that are enriched in lipid biosynthetic enzymes but deficient in canonical proteins associated with PML nuclear bodies (PML NBs). To identify the PML interactome during lipid stress, we employed proximity-dependent biotin identification (BioID) in U2OS cells expressing PMLI and PMLII fused to the ascorbate peroxidase APEX2 and cultured in the absence or presence of oleate to enhance lipid droplet formation. The resulting interactome included proteins enriched under oleate-treated conditions, such mitogen activated protein kinase-activated protein kinase 2 (MK2), ESCRT proteins and the COPII vesicle transport proteins Sec23B, Sec24A and USO1. COPII proteins co-localized with both PML-NBs and LAPS but were selectively enriched in PML-NBs following oleate treatment. The nuclear localization of USO1 was uniquely dependent on PML expression. Thus, the APEX2-PML proximity interactome implicates PML domains in the nuclear function of a non-canonical network of COPII vesicle trafficking proteins. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Llevarla más leve con la menopausia y andropausia es posible; que no haya esos cambios de humor, esos bochornos y todos esos síntomas característicos que a todo mundo traen de bajada, esto a través de una herramienta que resulta súper interesante que conozcas: las hormonas bioidénticas, ¿de qué se trata?, ¿cómo se usan? y ¿para quiénes son? Aquí te lo cuenta nuestro experto en Medicina Estética: el Dr. Sinué Orihuela, ¡a darle play de una vez! --- Send in a voice message: https://podcasters.spotify.com/pod/show/aquisehabladeotrascosas/message

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.24.534085v1?rss=1 Authors: Fuelle, J. B., de Almeida, R. A., Lawless, C., Yanes, B., Lane, E. B., Garrod, D. R., Ballestrem, C. Abstract: Desmosomes are multiprotein adhesion complexes that link intermediate filaments to the plasma membrane, ensuring the mechanical integrity of cells across tissues, but how they participate in the wider signalling network to exert their full function is unclear. To investigate this we carried out multiplexed protein proximity mapping using biotinylation (BioID). The combined interactomes of the essential desmosomal proteins desmocollin 2a, plakoglobin and plakophilin 2a (Pkp2a) in Madin-Darby canine kidney epithelial cells were mapped and their differences and commonalities characterised as desmosome matured from Ca2+-dependence to the mature, Ca2+-independent, hyper-adhesive state, which predominates in tissues. Results suggest that individual desmosomal proteins have distinct roles in connecting to cellular signalling pathways and that these roles alter substantially when cells change their adhesion state. The data provide further support for a dualistic concept of desmosomes in which the properties of Pkp2a differ from those of the other, more stable proteins. This body of data provides an invaluable resource for analysis of desmosome function. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.14.516495v1?rss=1 Authors: janer, a., Morris, J. l., krols, m., Antonicka, H., aaltonen, m. j., Lin, Z.-Y., Gingras, A.-C., Prudent, J., shoubridge, e. a. Abstract: Mitochondria interact with the endoplasmic reticulum (ER) at structurally and functionally specialized membrane contact sites known as mitochondria-ER contact sites (MERCs). MERCs are crucial for a myriad of physiological functions including lipid synthesis and transport, and calcium signaling. Alterations in the structure, composition or regulation of MERCs contribute to the aetiology of many pathologies including neurodegenerative and metabolic diseases. The proteins mediating the formation of MERCs have been extensively studied in yeast, where the ER-mitochondria encounter structure (ERMES) complex mediates the transport of lipids between the ER and mitochondria via three lipid binding SMP-domain proteins. However, none of the SMP proteins of the ERMES complex have orthologues in mammals suggesting that alternate pathways have evolved in metazoans. Combining proximity labelling (BioID), confocal microscopy and subcellular fractionation, we found that the ER resident SMP-domain containing protein ESYT1 was enriched at MERCs, where it forms a complex with the outer mitochondrial membrane protein SYNJ2BP. The deletion of ESYT1 or SYNJ2BP reduced the number and length of MERCs, indicating that the ESYT1-SYN2JBP complex plays a role in tethering ER and mitochondria. Loss of this complex impaired ER to mitochondria calcium flux and provoked a significant alteration of the mitochondrial lipidome, most prominently a reduction of cardiolipins and phosphatidylethanolamines. Both phenotypes were rescued by re-expression of wild-type ESYT1 as well as an artificial mitochondria-ER tether. Together, these results reveal a novel function of ESYT1 in mitochondrial and cellular homeostasis through its role in the regulation of MERCs. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Cofepris alertó riesgos de consumir hormonas bioidénticas, para tratar la menopausiaCNDH pide a consulados mexicanos exigir el esclarecimiento de los migrantes muertos en Texas AMLO se comprometió a esclarecer el caso de los 43 estudiantes de Ayotzinapa

Ann-Kathrin Freiberg of BioID joins us to unpack the misconceptions and prejudices around biometrics. She also discusses BioID's mission to raise awareness and understanding of attack vectors, the implications for identity verification, and what the future holds for biometric technology. “We want to make processes really secure, no doubt, but it's no reason to freak out over a new type of attack. It's more like, well, let's react to it and let's make it as secure as possible.” CREDITS   Host: Blair Crawford, Co-founder and CEO, Daltrey Guests: Ann-Kathrin Frieberg, Business Development and Technology Marketing Manager, BioID Producer: RadioHub Podcast Productions   LIKED THIS EPISODE? PLEASE RATE AND REVIEW. WANT MORE IDENTITY NEWS?   Follow us on LinkedIn   www.linkedin.com/company/daltrey/   Follow us on Twitter   https://twitter.com/DaltreyID   LET'S CHAT   If you have press inquiries, a topic suggestion or want to be a guest on the show, email us at hello@daltrey.com  See omnystudio.com/listener for privacy information.

O Fator de Crescimento para Barba Nanofactor® IGF Biotecnológico Don Alcides combina ativos Bio Estimulantes associados a óleos essenciais. Dermatologicamente e Clinicamente testado. Emulsão tônica em Gel – Não resseca a pele. Volume: 30g – 1 fl oz. Anvisa Grau 2. Como funciona o Fator de Crescimento para Barba Don Alcides? Terapia combinada de Fatores de Crescimento e Peptídeos Bioidênticos® para mimetizar os estímulos fisiológicos necessários que garantem resultados significativos e eficazes na aceleração do metabolismo folicular da barba. O Fator de Crescimento para barba Don Alcides age através de 2 fenômenos importantes: – Angiogênese: Estimula e gera novos vasos sanguíneos a partir daqueles já existentes. – Colagenogênese: Estimula a formação de novos fibroblastos aumentando a quantidade de colágeno disponível na derme. Estes dois fenômenos combinados aumentam a capacidade de nutrição do folículo piloso, bem como o aumento da malha folicular e consequente ganho de volume e densidade da barba. O aumento do colágeno, proteína formada por 3 mil aminoácidos, promove ainda maior resistência, espessura, crescimento e brilho à barba. O Fator de Crescimento para Barba Don Alcides reverte a atrofia folicular aumentando em poucos dias o tamanho dos folículos (bulbo). Ele acelera a mitose promovendo o crescimento saudável da barba. Conheça o produto: https://donalcides.com.br/produto/fator-de-crescimento-para-barba-nanofactor-biotecnologico/  Guia de minutagem do episódio: 00:00 - Introdução.  01:03 - Produto para crescer barba funciona?  01:38 - Como funciona o Fator de Crescimento para barba Don Alcides?  03:38 - Por que quando paramos de usar o Minoxidil, os pelos caem?  04:56 - Quanto tempo tenho que usar o Fator de Crescimento Don Alcides para ter barba? 

Las hormonas bioidénticas son una réplica exacta de lo que tu cuerpo produce. Se extraen de la soya, de la raíz del yam silvestre y otros extractos de plantas y se sintetizan en un laboratorio.

Dra. Lissandra https://www.dralissandra.com.br ✅ #1 INSCREVA-SE NO CANAL: http://youtube.com.br/dralissandra?su... ✅ #2 ME SIGA NO INSTAGRAM: https://www.instagram.com/dralissandra/

O médico intensivista Dr. Eduardo Pereira, recebe a endocrinologista Dra. Raila Teixeira para conversarem sobre os benefícios e uso de hormônios bioidênticos no processo de emagrecimento.

O médico intensivista Dr. Eduardo Pereira, recebe a Dra. Ana Paula Spadella para juntos conversarem sobre os hormônios bioidênticos.

Las hormonas son sustancias químicas especiales fabricadas por partes del cuerpo llamadas glándulas. Son mensajeros que le dicen a otras partes del cuerpo cómo y cuándo trabajar. Las hormonas controlan casi todas las tareas del cuerpo. Estos incluyen la función sexual y cerebral, el crecimiento y la descomposición de los alimentos. Cuando las hormonas están desequilibradas, pueden aparecer síntomas. Las hormonas bioidénticas se definen como hormonas artificiales que son muy similares a las hormonas producidas por el cuerpo humano. Las hormonas comunes que se combinan son el estrógeno, la progesterona y la testosterona. Estos se utilizan luego como tratamiento para hombres y mujeres cuyas propias hormonas están bajas o fuera de equilibrio. Algunas formas recetadas de hormonas bioidénticas están prefabricadas por una compañía farmacéutica. Otros formularios son hechos a medida por un farmacéutico según la orden de un médico. A esto se le llama capitalización. La Administración de Drogas y Alimentos de los Estados Unidos (FDA) ha aprobado una serie de preparaciones de estradiol y progesterona bioidénticos, que son molecularmente idénticas a la estructura de las hormonas generadas por el cuerpo humano. Han pasado por pruebas de seguridad y pureza y para asegurarse de que cada dosis tenga la misma cantidad de hormonas. Las formas compuestas no han sido probadas ni aprobadas por la FDA. Escucha el podcast en tu plataforma favorita: Spotify, iVoox, Apple Podcast, Google Podcast, Anchor.Fm, Breaker.Audio, Pocketcast y Radio Public. Si deseas contactarte conmigo para tomar sesiones de coaching hormonal, puedes mandarme un mensaje a cualquiera de estas direcciones: hola@alquimiahormonal.com, https://edusantibanez.com/, o puedes simplemente mandarme un DM en mis redes sociales. Quieres adquirir la Guía Menopausia Integral Lo puedes hacer a través de este enlace. https://edusantibanez.com/ebook/ Enlances y/o referecias de los estudios y artículos relacionados con el tema de hoy: Stuenkel, CA. and Manson, JE: Compounded Bioidentical Hormone Therapy: Does the Regulatory Double Standard Harm Women? JAMA Internal Medicine. Published online October 9, 2017. Available at: https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2656887 Accessed October 10, 2017. Cohen PA. Assessing supplement safety—the FDA’s controversial proposal. N Engl J Med. 2012;366:389-391. US Food and Drug Administration. Estrogen and estrogen with progestin therapies for postmenopausal women. Available at: www.fda.gov/Drugs/DrugSafety/InformationbyDrugClass/ucm135318.htm. Accessed October 13, 2017. Goodman NF, Cobin RH, Ginzburg SB, Katz IA, Woode DE. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Diagnosis and treatment of menopause. Endocrine Practice. 2011;17(Suppl6):1-25. Cobin RH, Goodman NF. American Association of Clinical Endocrinologists and American College of Endocrinology Position Statement on Menopause—2017 update. Endocrine Practice. 2017;23(7):869-880. Manson, JE et al. Menopausal Hormone Therapy and Long-Term All-Cause and Cause-Specific Mortality. JAMA. September 12, 2017. https://jamanetwork.com/journals/jama/article-abstract/2653735 Accessed October 12, 2017. ¡Aprende a entender a tus hormonas para que ellas trabajen para ti y no en tu contra! --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

Curso de Melasma: https://dralissandra.com.br/curso-de-... Produto citado no vídeo: https://www.dalissa.com.br/produto/ca... ✍ Ficou alguma dúvida? Pergunte para mim, vou ficar super feliz.

Converso nesse episódio com Dr. Jorge Mendes sobre infertilidade, ejaculação precoce, pornografia, ansiedade e câncer de próstata no homem.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.30.071365v1?rss=1 Authors: Rayner, S. L., Cheng, F., Yang, S., Grima, N., Ke, Y. D., Au, C. G., Morsch, M., De Luca, A., Davidson, J. M., Molloy, M. P., Shi, B., Ittner, L. M., Blair, I., Chung, R. S., Lee, A. Abstract: Background: Previously, we identified missense mutations in CCNF that are causative of familial and sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). CCNF encodes for the protein cyclin F, a substrate recognition component of the E3-ubiquitin ligase, SCFcyclin F. We have previously shown that mutations in CCNF cause disruptions to overall protein homeostasis; causing a build-up of ubiquitylated proteins (1) as well as defects in autophagic machinery (2). Methods: Here, we have used an unbiased proteomic screening workflow using BioID, as well as standard immunoprecipitations to identify novel interaction partners of cyclin F, identifying the interaction between cyclin F and a series of paraspeckle proteins. The homeostasis of these new cyclin F interaction partners, RBM14, NONO and SFPQ were monitored in primary neurons using immunoblotting. In addition, the homeostasis of RBM14 was compared between control and ALS/FTD patient tissue using standard IHC studies. Results: Using BioID, we found over 100 putative interaction partners of cyclin F and demonstrated that cyclin F closely associates with a number of essential paraspeckle proteins, which are stress-responsive proteins that have recently been implicated in ALS pathogenesis. We further demonstrate that the turnover of these novel binding partners are defective when cyclin F carries an ALS/FTD-causing mutation. In addition the analysis of RBM14 levels in ALS patient post-mortem tissue revealed that RBM14 levels were significantly reduced in post-mortem ALS patient motor cortex and significantly reduced in the neurons of spinal cord tissue. Conclusion: Overall, our data demonstrate that the dysregulation of paraspeckle components may be contributing factors to the molecular pathogenesis of ALS/FTD. Copy rights belong to original authors. Visit the link for more info

Oi gente! Nesse vídeo eu apresento à vocês um outro tipo de reposição hormonal. Com a ajuda de um profissional da área e esse tipo de tratamento, seu corpo vai voltar a produzir todos os hormônios que você perde na menopausa.

Voeltz explains how her lab used a BioID strategy to identify some of the proteins found at membrane contact sites between the ER and endosomes; a difficult task given the transient nature of contact sites.

Voeltz explains how her lab used a BioID strategy to identify some of the proteins found at membrane contact sites between the ER and endosomes; a difficult task given the transient nature of contact sites.

Mike and Joe attack the situation in the Gulf of Oman / Mike says listen to the end of all shows / Trump on Iran / Japanese Tanker Owner / Alex Jones on the Iran Situation / Admiral Suicide / Twiter Propaganda for the War / A list of why we should be skeptical of this attack / DC Swamp on the Iran Attack / How to get us to war with Iran / Shaping the Iran Debate / Tulsi Audio / Call from Idaho / Mikes balls call in again / Teacher had sex with student / Satanic party story / Fun Robot Video / Call from New Mexico / End / #### NEWS #### Trump blames Iran for tanker attacks in the Gulf of Oman https://youtu.be/UOhO-FqeLcI Japanese Tanker Owner Denies Ship Hit By Mine, Says Crew Saw “Flying Objects” Before Attack https://www.zerohedge.com/news/2019-06-14/japanese-tanker-owner-denies-ship-hit-mine-says-crew-saw-flying-objects-attack Navy Vice Admiral, Former Head of 5th Fleet, Died by Suicide in Bahrain https://www.military.com/daily-news/2019/06/12/navy-vice-admiral-former-head-5th-fleet-died-suicide-bahrain.html New Guy: Vice Admiral James Malloy https://www.navy.mil/navydata/bios/bio.asp?bioID=831 Speaker Nancy Pelosi on Iran https://youtu.be/2bOUZamRpY8 1 month ago : American Navy fleet could be ‘destroyed with one missile’, warns Iranian cleric https://youtu.be/9ryqCqoXjlE Hong Kong suspends controversial extradition bill after months of protest and criticism https://www.hongkongfp.com/2019/06/15/breaking-hong-kong-suspends-controversial-extradition-bill-months-protest-criticism/ Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. ▀▄▀▄▀ LINKS ▀▄▀▄▀ ► Phone: 614-388-9109 ► Website: http://obdmpod.com ► Patreon: https://www.patreon.com/obdm ► Subscribe Star: https://www.subscribestar.com/obdm ► YouTube: https://www.youtube.com/user/ourbigdumbmouth ► YouTube 2nd Channel: https://www.youtube.com/channel/UCrj4SPfo5ySkEnyaQAW5zvA ► Twitter: https://twitter.com/obdmpod ► Instagram: obdmpod ► RSS: http://ourbigdumbmouth.libsyn.com/rss ► iTunes: https://itunes.apple.com/us/podcast/our-big-dumb-mouth/id261189509?mt=2 ► Twitter: https://twitter.com/obdmpod ► Facebook: https://www.facebook.com/obdmnews ► Everything we do could be considered performance art ► Satire and Parody are often used

Former Nashville Mayor Karl Dean hosts a conversation with Rear Admiral Brian Pecha of the U.S. Navy along with TNWAC President Patrick Ryan. They discussed Navy Week in Nashville, Admiral Pecha's career in the Navy and the Navy's operations in support of national security around the world. “Global Nashville with Karl Dean” Podcasts present leaders from Nashville and other specialists who are connected with global issues or an aspect of the city and region that contributes to the international flavor. The conversations, with former Mayor Karl Dean, touch on their roles, experiences, and accomplishments in the city and region and their insights and perspectives on all of the things that make Nashville a “global city.” In this episode Karl talks with Rear Admiral Brian Pecha, U.S. Navy. Admiral Pecha, a Memphis native, was in Nashville for Navy Week in early June 2019. TNWAC President Patrick Ryan, a retired Navy man, joined the conversation. Run time: 36.41 Including his deployment to Anbar Province in 2006 at the height of the insurgency in Iraq. 01:43 Former Nashville Mayor Karl Dean Welcoming 02:02 “Tell us about what Navy is bringing to Nashville.” 03:44 “What is the impact on Navy public affairs of having sailors walking around Nashville?” 06:11 Talking to organizations around the community – Rotary, Vanderbilt, businesses, local leaders, people in service to the community. 08:03 “How did you get from where you were to where you are?” 10:56 Talking about service with the U.S. Marines, the “green side” of the Navy. 11:45 “Tell us about your deployment to Iraq in 2006.” 15:23 Talking about service at U.S. Pacific Command and U.S. Fleet Forces Command. 16:48 Break 17:33 “What’s going on in the world and how the Navy fits in?” 19:30 We live in a global neighborhood and not all the neighbors are friendly. 19:52 Talking about the Navy’s international humanitarian missions. 20:25 How much impact does the humanitarian mission have on Navy “optempo”? 21:37 “How has the rise of China and the Chinese Navy impacted the U.S. Navy? 23:11 Talking about Chinese expansion in the South China Sea and Indian Ocean. 24:15 “A large part of what we do is ensuring freedom of the seas.” 26:03 “Can you talk about Navy presence in the Middle East, Persian Gulf?” 27:40 Talking about Russian military modernization and their return to the world stage. 29:20 The new competition over Arctic access and resources. 30:35 “What would you say to a young Tennessean who dreams about seeing something different; what are the opportunities in the Navy?” 32:40 “Loved ones are always anxious to tell the story of their family member.” 33:29 “Army-Navy. What the heck is going on?” 34:15 Thanks to the World Affairs Council. Tennesseans can benefit from broadening their view of the world. Bio - Rear Admiral Brian S. Pecha, MC, USN, Reserve Fleet Surgeon, U.S. Fleet Forces Command https://www.navy.mil/navydata/bios/bio.asp?bioID=712

Episode 025: Swift Runner was a well respected Cree hunter and trapper outside Edmonton in the 1800's. In the 1870's his family, as were many others, began to go hungry. Swift Runner turned to alcohol to drown his frustrations and his personality quickly changed. He also began speaking of encountering Wendigo, an evil cannibalistic spirit, taunting him. Swift Runner's eventual crimes were shocking to all. BONUS: Rick Gibson eats a tesitcle or two.   CONTENT WARNING: Dark Poutine is not for the faint of heart or squeamish. Our content contains mature themes, coarse language and may include graphic descriptions of violent crimes. Listener discretion is strongly advised.   Web: http://darkpoutine.com/ Facebook: https://www.facebook.com/darkpoutine/ Twitter: https://twitter.com/darkpoutinepod Instagram: https://www.instagram.com/darkpoutine/  Email and PayPal tip jar: darkpoutinepodcast@gmail.com Patreon:https://www.patreon.com/darkpoutine   Writer / Creator, Researcher, Editor & Host: Mike Browne (@mikebrowne) Original Music & Cohost: Scott Hemenway (@sdhpics)   Sources: https://www.glenbow.org/index.cfm http://www.murderpedia.org/male.R/r/runner-swift.htm https://en.wikipedia.org/wiki/Wendigo https://en.wikipedia.org/wiki/Jack_Fiddler http://www.biographi.ca/en/bio.php?BioId=41285 https://en.wikipedia.org/wiki/North-West_Mounted_Police https://en.wikipedia.org/wiki/Fort_Saskatchewan http://www.sicc.sk.ca/archive/heritage/ethnography/cree/origin/oral.html http://www.thecanadianencyclopedia.ca/en/article/cree/ http://www.prairieghosts.com/wendigo.html https://www.legendsofamerica.com/mn-wendigo/ https://www.amazon.ca/Swift-Runner-Colin-Argyle-Thomson/dp/0920490409 https://www.amazon.ca/Canadian-Mysteries-Unexplained-Investigations-disturbing-ebook/dp/B005E07FNG/ https://www.amazon.ca/Wetiko-Legal-Principles-Anishinabek-Victimization-ebook/dp/B07B685Y4W/ Support the show.

Rear Admiral Kerry Metz (USN, Ret.) started his career as a Navy SEAL, and eventually served as the first commander of Special Operations Command North. In this discussion, Kerry talked about career success, career setbacks, and how “you can’t be a shiny penny without a few wire brushings!” Kerry shares his 5 H’s when it comes to leadership: honor, honesty, humility, humor, and happiness. He discusses the differences and similarities between the military, sports teams, business, and the shared commonality regarding leadership. Listen in to gain insights from a modern-day, intellectual warrior. Key Takeaways [3:01] Kerry progressed as a SEAL from the tactical area, through operational roles, and then to the strategic level as an admiral. The Special Forces, SEALs, and Rangers are tests for the human body and mind to do 10 times more than they think they can.  [5:48] A good team requires a common purpose or mission. Next, comes a shared experience or sacrifice. Everyone contributes to the best of their ability. These are the ingredients for a high-performing team. [7:33] Kerry talks about sacrifice in a startup. Employees sacrifice high salary for shares. Founders are often on the road more than most executives, for a later payoff. Sacrificing now gives you future options. [9:25] Kerry discusses how Naval officers achieve rank. Evaluations are not only for what they have done, but also their potential. Leadership is developing the leaders behind you. If something happens to you, the one behind you has to step up and take your place. [13:29] Kerry talks about his advancement. He was passed over for Lieutenant Commander once, but not the second time. When he was up for Commander, it also took two times. But he made One Star Admiral before his contemporaries. Kerry follows five ‘H’s: Honor, Honesty, Humility, Humor, and Happiness.  [21:13] Military groups fight in a mission to win or lose; sports teams play a game to win; but business can be a long slog. He cites Admiral Jim Stavridis, who said to be open, honest, and collegial, and Admiral Michael Mullen, who said to listen, learn, and lead. Leaders who apply these principles will lead well. [25:49] Competition among peers is healthy if it is balanced with cooperation. Leaders should lead people the way they need to be led. Some need a push, some need a pat on the back. Tell the contributors how they are doing, and what they need to do to be on the mark. [29:44] In 1989, Kerry tells a hard leadership lesson he learned as the Team Commander of SEAL Team One when they deployed to the Philippines.  [37:27] Put people in the right spot for them, nurture them, and empower them, and they will surpass your expectations and surprise you with their achievements.  [41:42] No one starts at the top. He would like to help others have a smoother ride, go further, and go faster. The world needs leaders to handle complexity.   LinkedIn: Kerry M. Metz Navy Bio:  Navy.mil/navydata/bios/navybio_ret.asp?bioID=655 Interview: Defensemedianetwork.com/stories/interview-with-rear-admiral-kerry-m-metz-us-navy Hall of Valor: Valor.militarytimes.com/recipient.php?recipientid=315229   Quotable Quotes Whatever you can do, think 10 times that. You are capable of it. Don’t let someone else determine where you’re going. You determine where you’re going. Stay on that path. You’re going to get through that obstacle. You’ve just got to keep trying. A high-performing team has a common purpose, a shared sacrifice, and everyone contributing to their best ability. “A good leader can get the most of his personnel even that aren’t going all the way to the top.” The bottom line is sustained superior performance. If something happens to you, the one behind you has to take your place. If they’re not ready, then that’s your fault. “If you’re doing something that you absolutely hate, my suggestion is, do something [about it].” “You can’t be a shiny penny without a few wire brushings, and I got more than my share.” The simplest solution is not always the best if there are unknown factors. Always listen to input.   Bio Rear Adm. Kerry Metz holds a Bachelor of Science in Business from the University of Colorado at Boulder and a Master of Business Administration from the University of Denver. He completed courses at the Air Command and Staff College, the Armed Forces Staff College and the Defense Language Institute. Commissioned via the Aviation Officer Candidate School in October 1984 and after a very brief time in aviation, he was assigned to the surface fleet where he served on USS Enhance (MSO 437). Transferring to Naval Special Warfare, he completed Basic Underwater Demolition/SEAL training with Class 149 in April 1988. He served in both Naval Special Warfare and Joint Special Operations assignments. Previous commands include a Naval Special Warfare Task Unit, a Joint Task Force, Naval Special Warfare Group 11, and six Naval Special Warfare Reserve Units. His service overseas includes multiple deployments to Operations Enduring Freedom and Iraqi Freedom. Metz served as the first commander of Special Operations Command North, a subordinate unified command of U.S. Special Operations Command under the operational control of U.S. Northern Command. Promoted to rear admiral in October 2011, he served first as the deputy commander and then as interim commander of Special Operations Command Central from September 2011 to July 2013. Books mentioned in this episode Authentic Leadership: Rediscovering the Secrets to Creating Lasting Value, by Bill George The Littlest Green Beret: On Self-Reliant Leadership, by Jan Rutherford Hillbilly Elegy: A Memoir of a Family and Culture in Crisis, by J. D. Vance Devotion: An Epic Story of Heroism, Friendship, and Sacrifice, by Adam Makos When Breath Becomes Air, by Paul Kalanithi Make Your Bed: Little Things That Can Change Your Life...And Maybe the World, by William H. McRaven Let My People Go Surfing: The Education of a Reluctant Businessman, by Yvon Chouinard The Death of Expertise: The Campaign Against Established Knowledge and Why it Matters, by Thomas M. Nichols Letters from a Stoic, by Lucius Annaeus Seneca Moonwalking with Einstein: The Art and Science of Remembering Everything, by Joshua Foer Team of Teams: New Rules of Engagement for a Complex World, by General Stanley McChrystal and Tantum Collins Start with Why: How Great Leaders Inspire Everyone to Take Action, by Simon Sinek The Secret Knowledge of Water: Discovering the Essence of the American Desert, by Craig Childs Younger Next Year: Live Strong, Fit, and Sexy — Until You’re 80 and Beyond, by Chris Crowley and Henry S. Lodge  

Emoji Law With Gabriella Ziccarelli – Is Google a Generic Term? – Unitary Patent Guide – Episode 86 – IP Fridays Profile of Gariella https://www.blankrome.com/index.cfm?contentID=10&bioID=3371

Download the action plan here: http://jimharshawjr.com/action/ Today I bring you Vice Admiral Kevin Donegan. On September 3rd, 2015, the U.S. Naval Forces Central Command (NAVCENT)/U.S. 5th Fleet /Combined Maritime Forces held a change-of-command ceremony aboard the aircraft carrier USS Theodore Roosevelt where Vice Admiral and former wrestler Kevin Donegan took command. Most of us have heard of CENTCOM, which is U.S. Central Command. NAVCENT, Naval Forces Central Command, is the naval component of CENTCOM. That’s what the Admiral does… he’s the Commander NAVCENT and the 5th Fleet. The area of responsibility encompasses about 2.5 million square miles of water area and includes the Arabian Gulf, Red Sea, Gulf of Oman and parts of the Indian Ocean. That comprises 20 countries! Vice Adm. Donegan is a 1980 graduate of my alma mater, the University of Virginia. His first operational assignment was with Strike Fighter Squadron 131 where he was among the first F/A-18’s to strike Libya. Donegan then commanded that same squadron, completing a deployment to the Arabian Gulf where he earned three command excellence awards. He also commanded the aircraft carrier USS Carl Vinson. He commanded Battle Force 7th Fleet and Carrier Strike Group 5 aboard USS George Washington. Donegan's most recent assignment was director of operations for CENTCOM. He served at the Pentagon as director of the Navy Quadrennial Defense Review (basically the budget review), and as the aide to the deputy chief of naval operations for Plans, Policy and Operations. He completed duty as flag lieutenant to the commander of Allied Forces Southern Europe in Naples, Italy. During that tour he deployed to Sarajevo as the NATO liaison to the commander of the United Nations Protection Forces serving as the principal air advisor during NATO's air strikes. Donegan graduated from several naval schools and colleges including the U.S. Navy Test Pilot School as the Outstanding Student, the Navy Fighter Weapons School (TOPGUN), as well as completed Harvard Kennedy School's Executive Education Program in National and International Security. His personal awards are far too numerous to list here. Let’s just say it would be like listing Bruce Baumgartner’s career awards and medals. His flying experience includes over 3,800 hours in 31 different types of aircraft and over 800 landings on 15 different aircraft carriers.(source http://www.navy.mil/navydata/bios/navybio.asp?bioID=402)   Let's connect:  Website | Facebook | Twitter About Your Host Jim Harshaw My name is Jim Harshaw. You and I were both wrestlers once so we’re coming from the same place, which is a good place for us to start. And I know where you’re at. You’re working hard and qualified for what you do but you aren’t getting what you want. You have plans on getting to the C-suite or launching a business but ultimate success seems as far away today as ever. You’re at the right place because you can get there from here. And I can help. Who I Am I’m a speaker, author and former Division I All American wrestler that helps motivated former wrestlers reach their full potential by getting clarity on their what they really want and taking agressive action to lead their ideal life.
 I’m a husband and father of four. And I’m a serial entrepreneur. I’ve launched multiple successful businesses as well as the obligatory failed one. I’ve been the executive director of a non-profit and have raised millions of dollars. I’ve worked in sales. I’ve even been a Division I head coach. While I was born in a blue-collar home I have spent my life surrounded by Olympians, CEO’s and millionaires. Jim Rohn said, “You are the average of the five people you spend the most time with.” I’ve been lucky. I’ve learned the habits of successful people and guess what. You’re just like them. I know because I know your type. You’re programmed for hard work, which is a prerequisite for success, but you’ve never been shown how to use what you know to create the life you want with the tools you have. I will show you how. Why You are Here You were a wrestler. You’ve trained and competed in the world’s toughest sport. You’ve set goals and maybe even set records. You’ve definitely failed and you’ve at some point found yourself questioning if you were on the right track. You need to understand this: You are far more prepared to succeed than those who’ve not trained, competed, struggled and overcome like you have. That’s the value of your education as a wrestler. You are prepared to be as successful as your wildest dreams will allow. Here I will teach you, with the help of brilliant minds that have been shaped by the learning that takes place in our sport, to be who you want to be. I sense that you want this because you have read this far. To take the next step today, click here. FOLLOW JIM Website | Facebook | Twitter  

Las hormonas bioidénticas, la menopausia y la andropausia por Félix Pedrero, que tuvo lugar en el Ateneo de Madrid el 27 de Junio 2015. --------------------------- http://www.ateneodemadrid.com http://www.frenarelenvejecimiento.com http://www.mindalia.com - La Red Social de Ayuda a través del Pensamiento http://www.mindaliaradio.com - La Radio del Pensamiento Positivo http://www.circulosdeayuda.com Los videos de esta y otras conferencias y entrevistas de interés en http://www.mindaliatelevision.com Puedes escuchar este y otros audios en http://mindaliacomradio.ivoox.com

Las hormonas bioidénticas, la menopausia y la andropausia por Félix Pedrero, que tuvo lugar en el Ateneo de Madrid el 27 de Junio 2015. --------------------------- http://www.ateneodemadrid.com http://www.frenarelenvejecimiento.com http://www.mindalia.com - La Red Social de Ayuda a través del Pensamiento http://www.mindaliaradio.com - La Radio del Pensamiento Positivo http://www.circulosdeayuda.com Los videos de esta y otras conferencias y entrevistas de interés en http://www.mindaliatelevision.com Puedes escuchar este y otros audios en http://mindaliacomradio.ivoox.com