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In this episode, Lewis and Danny talk about New Who Season One, Episode Twelve, Bad Wolf! We now have merch! Make sure to check out what we've got on offer at teespring.com/stores/shouting-into-the-void Like what we do? We do a lot more! Check us out at http://www.patreon.com/shoutingintothevoid to see everything else we do, and consider supporting us there as well! If a monthly donation isn't your thing, but you'd still like to support us, then please consider donating to us through paypal: paypal.me/VoidPodcast Music from https://filmmusic.io: "Acid Trumpet" by Kevin MacLeod (https://incompetech.com) Licence: CC BY (http://creativecommons.org/licenses/by/4.0/)
Welcome to Episode Twelve! In this installment, I talk with Dr. Emily Taylor, professor of biological sciences at Cal Poly (California Polytechnic State University), and we cover a number of topics, including rattlesnakes and leopard lizards. Dr. Taylor is pursuing some fascinating lines of research and her passion for her work comes shining through. Now this episode comes with some homework - I want you all to read "Squirrels vs Rattlesnakes", an article Dr. Taylor posted to medium.com just a few days ago. You'll be glad you did! We also talked about her Rattlesnake Beauty Pageant Calendar project - I know many of you will be interested, and 100% of the proceeds from sales of this calendar will benefit Advocates for Snake Preservation. Dr. Taylor sent out a call for high-quality photos of our buzzy pals, and when the herp world responded, she chose the best of the best for this calendar. Check it out! I pre-ordered mine today. You can also follow Emily on FaceBook, Twitter, and Instagram - she's "@snakeymama" on TW and IG. The cartoon image of Emily featured here is her Twitter avatar, and was rendered by Ethan Kocak, who also did the artwork for this show! He does good work. Thanks so much for coming on the show, Emily, I enjoyed our conversation and my brain is still in high gear thinking about some of the things we talked about! Thanks for listening, everyone! The show email is somuchpingle@gmail.com, and there’s also a So Much Pingle group on Facebook, for discussion, comments, feedback, suggestions, robot burrow-cams, herp confessions, tips for herping better, etc. Stay tuned for more episodes! And don’t forget to herp better! -Mike
Episode Twelve of the Endurance Sports Running podcast with Anthony Clark @fragilerunner and Stephen Cook @rustytrowel. Plus interview with Damian Carr @damocarr83, Mountain Fuel and Coros Global and @XMilesUK Squirrels Nut Butter ambassador on his recent Ridgeway Double #ridgewayback2back FKT 175.24 miles with 14,885ft.Produced by XMiles @XMilesUK Episode sponsors Unived UK on Instagram HOW TO CONTACT THE ENDURANCE SPORTS RUNNING PODCAST; Join the discussion 'Endurance Sports Running' Podcast Facebook Group URL: http://ERS.buzzsprout.com RSS: https://feeds.buzzsprout.com/239636.rssShow supported by UNived UK Click here to apply discount code ‘ESRPODCAST‘ 10% Discount at XMiles.co.uk
Aggravating Circumstances Season One Episode Twelve. The continuing story of the wrongful conviction of Destry McKinney. Season One of Aggravating Circumstances tells the story of Destry Cord McKinney a musician, studio producer, combat medic and father. It's a tale of hidden evidence, unintended consequences and a wrongful conviction. This is a continuing story so be sure to start with episode one. See more at AggravatingCircumstances.com Episode Twelve discusses the hidden evidence.
In this third part of our wide-ranging discussion with functional nutritionist, Tracy Siegel, we get into the ground rules of good nutrition, what healthy eating is – and is not – and how different diet trends from keto to intermittent fasting stack up in terms of tangible health benefits. When we recorded these episodes on the essentials of good nutrition for balancing our health and hormones, reducing obesity and preventing disease, little did we know how crucial this information would become in light of COVID-19…Emerging data during the pandemic tells us that the disease is much more lethal for those with obesity and/or diabetes, who are not only at greater risk of contracting the virus but of succumbing to it. News like this should serve as a powerful reminder that eating right and maintaining a healthy weight not only protects us but can save our lives! Join us for a fast-moving conversation that we hope will answer your ‘weighty’ questions and cheer you up with the certainty in these uncertain times that good food is good medicine! Show notes for Episode Twelve
Episode Twelve features John E. Dowell, Jr., a nationally recognized artist. His work captures the pulse of cities and agricultural landscapes of America in his large-scale photographs. Working primarily from sunset until dawn, he focuses on the surface of buildings, the reflections of their exteriors and, quietly, their interior spaces. Illuminating the unseen, he brings awareness to a single moment. In this episode we focus on 'COTTON: THE SOFT, DANGEROUS BEAUTY OF THE PAST' and the history of slavery in New York City. An artist and master-printer for more than four decades, Dowell’s fine art prints, paintings and photographs have been featured in more than 50 one-person exhibitions, and represented in the permanent collections of 70 museum and public collections. Among them are the Museum of Modern Art and the Metropolitan Museum of Art in New York City, the Museum of Fine Arts, Boston, the San Francisco Museum of Modern Art, and the Bibliothèque Nationale in Paris, France. Dowell’s photographs are in the Houston Museum of Fine Arts and have been added to his work in the collections of the Fogg Museum of Harvard University, the Museum of the Rhode Island School of Design and the Lehigh University Museum. John Dowell is a Philadelphia native and Professor Emeritus of Printmaking at the Tyler School of Art at Temple University. https://johndowell.com/ http://www.laurencemillergallery.com/exhibitions/john-dowell https://hyperallergic.com/485798/cotton-the-soft-dangerous-beauty-of-the-past/
Episode Twelve of the Punk Rock Classrooms Podcast! "Positive Hardcore...Positive Schools" Positive Hardcore was a movement about unity, building each other up, and fighting against the things that tore us apart. In this episode, Mike and Josh explore what positivity and kindness mean to them in education. They talk about how our attitude plays a role in shaping our schools and classrooms and how being positive doesn't mean you put on your blinders to injustice or inequity but that you attack those things with love and by gathering people together not by dividing us even further. Twitter twitter.com/punkclassrooms twitter.com/educhefearnshaw twitter.com/JoshRBuckley Intro music - "Walk Together Rock Together" by 7 Seconds Outro music - "Anthem of Positivity" by Good Clean Fun
R2 is missing and Jar Jar is a Jedi?! What in the galaxy is going on this week? We’ll get to the bottom of these mysteries and more as we continue our viewing of The Clone Wars. This week we discuss episode 5-8 of Season One and we make a request that you all raise your right hand and reach out with the force and touch someone special. Turn up your headphones, dial back your sensibilities, and join the wretched hive of scum and villainy as we take the low road to resistance on Episode Twelve of Force Insensitive!Send Email/Voicemail: mailto:forceinsensitive@gmail.comStart your own podcast: https://www.buzzsprout.com/?referrer_id=386Use our Amazon link: http://amzn.to/2CTdZzKFB Group: https://www.facebook.com/groups/ForceInsensitive/Twitter: http://twitter.com/ForceNSensitiveFacebook: http://facebook.com/ForceInsensitiveInstagram: http://instagram.com/ForceInsensitive
It's Taking It Down back for Episode Twelve where contributor to the site and cohost Adam Morrow helps Blaine break down the best movies of the decade (02:12). Then in the back half of the pod, Blaine sits with frequent guest and contributor Donovan Reinwald to discuss the recently wrapped first half of the final season of the NBC comedy with a philosophical slant The Good Place (47:02).
Death Is A Business is here for Episode Twelve of Fly On The Call. The self-described heavy metal band with an identity crisis recently released their debut album, Not Infinite, which is the product of nearly five years of writing, recording, and collaborating. This conversation hits on diversity in both music and community, hard work, presentation , artistic value, and much more. Enjoy! Links: Death Is A Business - Website | Spotify | Instagram | Twitter LOUD Music, LOUD Politics, LOUD Weed! EduPunx Podcast - Website | Instagram | Twitter Fly On The Call - Twitter | Instagram | flyonthecallpod@gmail.com Promoted by The Alternative - Website | Twitter | Patreon | Mixcloud Artwork by Mikaela Jane Palermo - Website | Twitter | Instagram Theme song by Kailynn West of Tiny Stills - Website | Twitter | Bandcamp
Episode Twelve! In which J & Lazy N chat with someone who has well over 800X their social media footprint... Listen to J develop a creative man-crush, to more than one last-minute transition, and to Lazy N do a podcast without alcohol. One might think this is a Halloween episode, but no! MayoKing Comics by Brian King Our music is "Back to the Grind" by Billie Stevens. Podcast logo by Lazy N & Micah Myers. You can find J & Lazy N Ramble On... at Anchor.fm and Spotify, or subscribe wherever you currently subscribe to podcasts, including Apple Podcasts, Google Podcasts, Castbox, &tc. We now have merch! Check out our wares at TeePublic. You can also support us at Patreon, follow us on Instagram, Twitter, and Facebook, leave us a voice message, or email us at jandlazyn@gmail.com --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app
How do you start a fashion brand from scratch? We find out in Episode 12 of the Planetary Potential! The Planetary Potential is hosted by Andrew P. Rowan and is recorded on location. This is Episode Twelve of Season One which features 20 episodes with a common theme of Peru. For a transcript of this episode, head over to https://andrewprowan.com/episode-12-of-the-planetary-potential-with-ileana-tapia. For exclusive bonus content, including extended versions of this and other interviews, head over to https://www.patreon.com/planetarypotential --- Send in a voice message: https://anchor.fm/planetary-potential/message
Welcome to Episode Twelve of Apocalypse. A Strange Pleasures Radio Lab production, written and narrated by Robert KnightAMAZON AUTHOR PAGE https://www.amazon.co.uk/Robert-Knight/e/B07WH3QCML/ref=dpbylinecontpopebooks_1HOME WEBSITE https://apocalypse-a-strange-pleasures.pinecast.co/STITCHER https://www.stitcher.com/s?fid=474043&refid=stprLUMINARY https://luminarypodcasts.com/listen/robert-knight/apocalypse-a-strange-pleasures-radio-lab-production/7531c80b-c2a2-4e19-b716-cffa3c9a41c9SPOTIFY https://open.spotify.com/show/0Nho9kQE1zhfsgVN5rwWPEITUNES https://podcasts.apple.com/gb/podcast/apocalypse-a-strange-pleasures-radio-lab-production/id1483662157Twitter: @LabStrangeSupport Apocalypse: A Strange Pleasures Radio Lab production by donating to their Tip Jar: https://tips.pinecast.com/jar/apocalypse-a-strange-pleasuresFind out more at https://apocalypse-a-strange-pleasures.pinecast.coThis podcast is powered by Pinecast.
How do you end up the editor in chief for a major online Zine? You volunteer, of course. David Speakman joins Jeannie and Dave (Web Spider) to talk about his writing career progression, Tightbeam Magazine, and more. … Continue...Episode Twelve – Online Zines and Game Writing
Welcome to Episode Twelve of Strange Pleasures Radio Lab. Your daily audio story podcast available through iTunes, Spotify and YouTube.Each day I will narrate a well known story in it's entirety. As a writer I will also include some narration of my own books that can be purchased through the Amazon Kindle Store, or through the Amazon Prime Kindle Unlimited subscription program.Today I will be narrating August Heat by WF Harvey.YOUTUBE: https://www.youtube.com/channel/UC8MoqBN8-vdAsaoYBZX32OA?viewas=subscriber?subconfirmation=1HOME WEBSITE https://strange-pleasures-radiolab.pinecast.co/SPOTIFY https://open.spotify.com/show/6x2VOcohjOKeJ8ZIJpvi8rAMAZON AUTHOR PAGE https://www.amazon.co.uk/Robert-Knight/e/B07WH3QCML/ref=dpbylinecontpopebooks_1ITUNES https://podcasts.apple.com/gb/podcast/strange-pleasures-radiolab/id1476208251Support Strange Pleasures Radiolab by donating to the tip jar: https://tips.pinecast.com/jar/strange-pleasures-radiolabFind out more at https://strange-pleasures-radiolab.pinecast.coThis podcast is powered by Pinecast.
Welcome to Episode Twelve! Before we get into a description, here's your PSA - Spay and Neuter your pets people!!! Thanks! Today we discuss a whole bunch of life events! Gina gave up her foster kittens, is graduating soon, and got a big kid job! Melissa is just concerned for her liver. We talk Skinwalker Ranch, and the Black Dahlia murder, the key suspect of that murder, and spill even more tea sis. You know, things happen. Thanks for listening! We
This is EPISODE TWELVE of the podcast and we continue with “Life’s Meaning & Purpose: An in-depth study of the Gospel of John” taught by the rector of St. Bartholomew’s Fr. Arthur Ward.In this episode Fr. Ward finishes Chapter 4 and begins to unpack Chapter 5 focusing on verses 1-23.
This week we see what they've been saving up all that animation budget for when the symbol of peace drop kicks a bird through the stadium roof with his fist. We learn some things about first aid and friendship and Mary Shelley's gothic horror masterpiece Frankenstein. Come and join in on the literary discourse on twitter @MyHeroNotebook. It's perfect for writing last-minute term papers!
Episode Twelve is focused on tips, tricks, and hacks that will help you get the most out of your experience at the AOTA Annual Conference in New Orleans in early April. I guarantee that you will find something helpful, insightful, and/or inspirational from this episode if you are going to the national conference. Tips address everything from portable chargers to your morning coffee to scheduling your time to which events will give you the most bang for your conference buck. Please let me know what you think of the episode, or send along your own tips, tricks, or hacks for a successful conference at iloveotpodcast@gmail.com or catch me in New Orleans and tell me in person. Thanks for listening to this episode and all the great OT podcasts out there!
Episode Eleven continues our discussion on motivation! Now we're talking about how to sustain motivation and engagement over longer term programs and interventions. What are the keys to sustained success and what barriers need to be avoided when we want to make motivation and engagement endure for the long haul? I hope you enjoy, let me know what you think at iloveotpodcast@gmail.com. Episode Twelve will get us ready for the annual AOTA conference in New Orleans. Can't wait!
Episode Twelve of the kind of wrestling adjacent podcast by the high flying death defying luchador Lucha DS Officially sponsored by Masked Republic Follow Lucha DS on social media Facebook https://en-gb.facebook.com/luchaDS/ Twitter https://twitter.com/luchads?lang=en Instagram https://www.instagram.com/luchads/?hl=en YouTube https://www.youtube.com/channel/UC5FVmhw5098RETSkKmcOCsg
Hello People, welcome to Episode Twelve with my guest Nigel Powell of Frank Turner and The Sleeping Souls, The Sad Song Co and Dive Dive. Nigel was a pleasure to chat to and we covered many aspects of his career, his introduction to music and also agreed that Leeds is the spiritual home of Frank Turner and The Sleeping Souls. Check out his work: http://www.thesadsongco.com https://frank-turner.com http://www.divedive.co.uk As mentioned, here is a link to the When In Yorkshire Podcast, Spotify Playlist: https://open.spotify.com/user/minmnq66ijvdq9jsrjzyvfyhl/playlist/5WguWZu1N8br97h97FOXXm?si=00nlMcU1Q1izyvo6PPtAfA
Join Sean Baligian and Jonathon Kidd for Episode Twelve of the State Champs! High School Hockey Report Podcast presented by the Michigan High School Hockey Coaches Association and it's also brought to you by National Coney Island and the MHSAA. Jonathon and Sean talk about the latest Top 25 Rankings. We salute the coaches that were on the STATE CHAMPS! High School Hockey Report during the regular season. Jonathon and Sean finishes the show with the National Coney Island High School Hockey Player of the Year Update and recap the 2018-19 regular season.
The GET TO WORK HURLEY podcast is a monthly rant about the hustle of making a living as a writer of All of the Things. You can support this podcast each month as a Patron or make a one-time donation. EPISODE TWELVE In this special holiday pep talk edition, we’re spreading some cheer with a special GtWH audio rendition of my Sirens Keynote on … GET TO WORK HURLEY. Episode 12. History, storytelling, and narrating our way to a better future. Read More » https://www.kameronhurley.com/wp-content/uploads/2018/12/GET-TO-WORK-HURLEY-Ep12.mp3 Podcast: Play in new window | Download The post GET TO WORK HURLEY. Episode 12. History, storytelling, and narrating our way to a better future. appeared first on Kameron Hurley.
In this week’s episode of COSMOS AND THE CITY: THE SEX AND THE CITY PODCAST, your host Megan McIver will sit down with the double trouble in the form of Caitlin Sacks & Grivas Kopti. Together these three will discuss Season Three, Episode Twelve of SEX AND THE CITY entitled: “Don’t Ask, Don’t Tell”This week Megan, Caitlin, and Grivas will be sorting through: Samantha and her communication problems with a hunky Scotsman, Charlotte and her pre wedding jitters, Miranda lying about her job to get more dates, and Carrie coming clean to Aidan.Plus we’ll have all your favorite segments: Hottie of the Week, Pun of the Week, Good Big Bad Big, Who Wore What Why?, and You’re Such a _________.Will Samantha discover body language? With Charlotte shake off her cold feet? Will Miranda overcome her occupational hazard? Will Carrie be able to keep Aidan in her life? Through all the craziness Megan, Caitlin, and Grivas will share their thoughts on ABSO-FUCKING-LUTELY EVERYTHING.EPISODE SYNOPSIS: “Frustrated with being single and only being hit on by talking sandwiches, Miranda tries out multi-dating where she learns being a corporate lawyer isn't doing any favors for her sex appeal. When she pretends to be an airline stewardess though, she catches a date with Harris, an emergency room doctor. The morning after one of her spark-filled nights with Harris, Miranda cuts her finger, only to learn that Harris isn't a doctor after all. Instead of fessing up to her own impersonations, Miranda acts disgusted and tells Harris to leave. Meanwhile, the girls go out on the eve of the Charlotte's wedding, for her last night as a single woman. Everyone is totally stunned by Charlotte's admission that she and Trey haven't had sex yet. But after more drinks than she can handle, Charlotte shows up at Trey's place ready to get busy. Unfortunately though, things don't work out in bed for Trey, and Charlotte gets a little nervous. Carrie's nerves are also getting the best of her as she considers whether to tell Aidan about her affair with Big. Just minutes before Charlotte's wedding, Carrie drops the bomb. Aidan is devastated and walks off. At the wedding, Charlotte gets last minute jitters about Trey's sexual under-performance, but Carrie calms her down with a white lie, and Charlotte walks down the aisle. Aidan shows up after the wedding and says he loves Carrie, but knows he will never be able to let go of the fact that Carrie cheated. Carrie breaks down crying, but takes some comfort in knowing that at least she has three friends who love her no matter what she does.”Thanks for listening! If you wanna support our show by shopping on Amazon, use our link.Our Host: Megan McIver• Twitter• Instagram• FacebookOur Guest: Caitlin Sacks• Instagram• WebsiteOur Guest: Grivas Kopti• IMDBWhat We Watched:• Sex and the City Season Three Episode TwelveCosmos And The City Social... See acast.com/privacy for privacy and opt-out information.
Welcome to Episode Twelve! Here we cover familicide - and yes its as sad as it sounds. Brittany covers the case of Ronald Gene Simmons - half beard half man - who went absolutely berserk on his family. Grace then covers the depressing case of Canadian born professional wrestler Chris Benoit. Enjoy!
Welcome to Episode TWELVE of the Loathed Strangers Podcast. Still just about delivering that one instalment per week. Phew! For this episode I was joined by award winning journalist and Town fan, Sam Morshead, who like each and every guest of the podcast to date was an absolute delight to talk to. But Wow! Sam talks of his time covering Swindon Town for the Advertiser and Total with the sort of passion and enthusiasm that you'd come to expect from somebody who has followed the club since he was knee high to grasshopper (or about 8 years old, whatever). The Andrew Black Era The Jed McCrory Era The Lee Power Era We got through loads but probably missed a fair whack out too. Hope you enjoy listening to this as much as I did whilst recording. Enthralling insight to a batshit crazy era. WARNING: Swearing included. Except the C-Bomb. I censored the C-Bomb. Eek. Football is great, isn't it!? All of the #LSPod guests volunteer their own time to discuss football with me and I’m very much grateful for it. Thanks, as always, for listening and I really hope you enjoy! Rich Facebook: The Loathed Strangers Twitter: @loathedstranger Instagram: @theloathedstrangers loathedstrangers@gmail.com Music by Matthew Kilford Artwork by John Daglish Producer: K.P.
Episode Twelve of Ms. Demeanor & Ms. Conduct. A bi-weekly, light hearted look at all things mysterious in Canada. Tales of murder, mystery, conspiracy, cults & much more. This week, we bring you two Canadian heavy hitters. Kennedy starts things off with the story of the first known American sex serial murderer of the twentieth century, Earle Leonard Nelson. And Jena lays out the facts of the Monster of Miramichi, Allan Legere.
Episode Twelve. From Rodeax, the company that bought you Tales from Wytch Haven and In The Frame: The Film Review Podcast, now brings you; The CLASSIFIED Transmissions. A short 24 episode series. The Cronos Star liner has become over run with a deadly being known as the krill. Follow one mechanic's mission as he tried to save himself and anyone else that hasn't been met with the slaughter the krill bring with them. Created by Dan Lee & Rodeo Whiter Voiced by Dan Lee & Rodeo Whiter Introducing Phill Boobyer Produced by Rodeax Ltd.
In this week’s episode of COSMOS AND THE CITY: THE SEX AND THE CITY PODCAST, your host Megan McIver will sit down with the fantastic Eva Morreale. Together these two will discuss Season Two, Episode Twelve of SEX AND THE CITY entitled: “La Douleur Exquise!”This week Megan & Eva will be sorting through: Samantha and her favorite new restaurant, Miranda and her man’s love of PDA, Charlotte and the shoe salesman’s foot fetish, and Carrie learning that Big may be moving to Paris (DA FUQQQQ).....Plus we’ll have all your favorite segments: Hottie of the Week, Pun of the Week, Good Big Bad Big, Who Wore What Why?, and finally You’re Such a _________.Will Miranda continue to take it to the streets? Will Charlotte continue to sell her soul for a shoe discount? And will Carrie leave behind the city she loves for the man she loves??? Through all the madness Megan and Eva will share their thoughts on ABSO-FUCKING-LUTELY EVERYTHING.EPISODE SYNOPSIS: “Samanatha invites the other three girls to a restaurant opening which her PR firm gave a blatant SM theme, but rightly points out that everybody else has a fetish too, just less obvious. For Miranda one is reading historical biographies, for the man she meets browsing trough some too it's having sex in places where they can get caught - their last time being at home by his parents. For Charlotte it's just shoes, and for a shoe salesman its (fitting them on) beautiful feet like hers, but is that reason enough to accept him giving her up to 100% discount? Carrie has another big row with Mr. Big as he announces a long business trip to Paris, maybe for 6 months, without even consulting her - but does she really want to break with him for doing his job? Meanwhile Stanford confides in her his fetish, cyber-sex under the alias Rick9plus and accepts an invitation from a certain BigTool4U, which turns out to be in an underwear only-club..."Thanks for listening! If you wanna support our show by shopping on Amazon, use our link.Our Host: Megan McIver• Twitter• Instagram• FacebookOur Guest: Eva Morreale• Instagram• TwitterWhat We Watched:• Sex and the City Season Two Episode TwelveCosmos And The City Social Media• Instagram • Facebook• Twitter• WebsiteMusic by Jon Fredette • Website See acast.com/privacy for privacy and opt-out information.
Switching it up for Episode Twelve! We would LOVE to get to know our listeners, so find us on Facebook or Instagram @tiredasamotherpodcast or shoot us an email at tiredasamotherpodcast@gmail.com, and send us your funny mom (or dad!) stories! We discuss how we sleep without our husbands and April’s is usually filled with figuring out … Continue reading the one where someone cries →
Celebrating a year of radio-making from inside the incubator of Studio B at Radio Fabrik, in EPISODE TWELVE we discuss with Program Coordinator Eva Schmidhuber the historical geography of this collectively-owned community radio station in Salzburg. We review the first season of episodes and plan ahead as Geographical Imaginations grows wings.
Episode Twelve is a conversation with Kevin Cafferty. We talk about the film he made called It's a Bash about RI band Neutral Nation, growing up in Rhode Island, his radio show he had for a long time as well as his work in television. Kevin is an interesting and funny guy and I learned quite a lot from him.
EPISODE TWELVE is here! in our pre-holiday ep, we discuss some recent pop culture news, what we’ve been watching & listening to, plus we deep dive into our favourite space opera: STAR WARS and more specifically, the last jedi. BEWARE OF SPOILERS (from 1hr 4mins onwards!)
Episode Twelve of Denver Orbit features these things: Janae Burris recorded live at the Comedy Works. The song King of the Fairies by Avourneen. And Ryan Connell brings us a cringe-worthy diary entry from when he was a young lad. The music of Podington Bear, Kevin Macleod, Pierlo and Keshco was used in Ryan’s piece. … Continue reading "Episode Twelve: Not a Holiday Special"
Episode Twelve of Denver Orbit features these things: Janae Burris recorded live at the Comedy Works. The song King of the Fairies by Avourneen. And Ryan Connell brings us a cringe-worthy diary entry from when he was a young lad. The music of Podington Bear, Kevin Macleod, Pierlo and Keshco was used in Ryan’s piece. … Continue reading "Episode Twelve: Not a Holiday Special"
On the programme this week is the architect Patty Hopkins. Patty studied architecture at the Architectural Association where she met her future husband Michael Hopkins. After graduating from the AA Patty ran her own practice whilst Michael worked in partnership with Norman Foster. But in 1976 the couple decided to start their own firm together … Continue reading "Patty Hopkins – Episode Twelve"
Episode Twelve features guest Sir Boo Berry for the second time, with host Captain Death, comin atcha with them spooks. He's one of the best reviewed by our listeners, after his first episode, so we'll be sure to get him back on again!The Nearly Departed(6:28)Open Letter to the Woman at Walmart(13:48)There's Another Daddy in the House(29:55)Maggie(35:45)They're Everywhere(45:42)9-1-1(49:38)CHECK THE YOUTUBE for EPs! SUBSCRIBE @https://www.youtube.com/channel/UCxoqIN-fkfdlmGEjWujypxwFeaturing wonderful ambient music from our fam in Sweden: CryoChamber, givin' us all the ooky-spooky tunage. Follow: @cryo-chamberThank you!"Are You Afraid of the Dark Theme Song," "Spooky Skeletons REMIX," and "You Reposted in the Wrong Neighborhood" are not my songs. Credit and All rights are reserved by the owners
Shaun and Scott respond to voicemails, emails and social media after Episode Twelve, Unit 2226. Sponsors in this episode: OpinionOutpost.com/unconcluded Stamps.com (enter "unconcluded") Social: @unconcludedpod Web: http://unconcluded.com Email: unconcludedpod@gmail.com Support on Patreon: https://www.patreon.com/unconcludedpod Music by Lee Rosevere / CC BY NC: http://creativecommons.org
Episode Twelve of the soon to be acclaimed podcast; Beers, Beats and Battlestar Galactica featuring Leesa Charlotte and Melia Rayner. Leesa is sad that I haven't been writing little blurbs here recently, so Leesa, here you go. It's been a pleasure producing the Pod for you guys - Producer Tom. Twitter/Instagram @beersbeatsbsg beersbeatsbsg@gmail.com
Episode Twelve features Jessixa Bagley, author & illustrator of Boats for Papa, Before I Leave, and Laundry Day. This Porchlight episode was recorded live when Jessixa led our last Picture Book Intensive. In this conversation we discuss Jessixa's fondness for anthropomorphic creatures and the rich imagery they provide in her own picture books. Jessixa sheds light on the struggle of writing about the difficult theme of an absent parent in Boats for Papa. She also discusses the challenging yet rewarding process of writing a new picture book with her husband, also and author & illustrator, and their different roles in this new partnership. Thank you for listening. Please share your comments and thoughts on the podcast with us. Rate us on iTunes, Google Play or Sticher—share the Porchlight with others. And remember to retreat, create and celebrate. Links: Jessixa Bagley Picture Books That Deliver Eureka Moments
Listen to Episode Twelve of Womankind as author Alyssa Palombo and I geek-out over literature! Author of two historical fiction novels, Alyssa discusses her writing process, the importance of reading about resilient women, and the problematic term “strong female character”. We also get into Alyssa’s personal beliefs about womanhood and the ideal of all women supporting women.
Episode Twelve sees Nick remembering 'The Changes' from 1975. Warren helps us with an analysis of James Burke's 'Connections' as well as our own connections. Michael Seely talks of Kit Pedler and 'Doomwatch' while Paul recalls some early TV-related dreams. We pay tribute to Brian Cant and take a trip to Trumptonshire to celebrate the work of Gordon Murray.
Episode Twelve of Idea Pod. In this episode, we interview Allisha, our golden star graphic designer. Listen in on her views on creativity as creative interviews creative. Read More The post #12 Our designer designs…and talks appeared first on Bandwidth Marketing.
We accidently bash on mothers. The writers managed to find something ickier than the one where the monkey is literally screwing everything in sight. We shed the shanking monkey. We sneak in some more Star Wars goodness. Brandon does sexy-cold-voiced Moe AND Chandler AND Pheebs (sort of). We play with teeth. So many Dino Puns. Jozi takes a shot at blind bunnies. They go down hard. June 8, 2017 SCORING It’s a split. Jozi snags the Ick. Brandon - 222Jozi - 14 FUNNY ROSS TALLY Monica - 3 Ick - 9! Overall - 85 RECORDING AND EPISODE DETAILS: S1:E21 | The One with the Fake Monica|Aired April 27, 1995 | S1:E22 | The One with the Ick Factor|Aired May 4, 1995 | This was recorded in Alaska and Oregon, USA (not) in front of a live studio audience (unless you count dogs) on June 3rd, 2017. NEXT WEEK We’re at the end of Season 1 already! Episode Twelve is next Thursday: The One with the Birth and The One Where Rachel Finds Out EXTRA We cut out 2:50 worth of Brandon trying to recreate a cut scene. You’re welcome. #iheartpheebs #mahnamahna #monkeyluvin #dinopuns FEEDBACK Find us at Moopodcast.com or on Twitter: Jozi | Brandon | Moo Point Email the show Of course we have a Facebook Page Moo Point, A Friends Podcast 012 - T1W Jozi Mahnas and Brandon Doo Doos
In Episode Twelve of the Award Winning podcast "Man Versus Yoga" we have Part One of our visit with the multi-faceted Dee Dussault, author of the soon to be released and very well reviewed book "Ganja Yoga" by HarperCollins. Having read "Ganja Yoga", I can testify to its greatness and have become fanboy number one for Dee. Episode Twelve continues our tradition of commenting on Life from the view of a yoga mat, rich in hyperbole and eccentricity.
Episode Twelve. Hosted by Richard B McLean and Adam Cloud . We discuss Coding, The Art and Music Inside, Education Oddities, Podcasts, Etc.. Jordan Clark discusses influence, and where the art comes from. Featured Media This Week: Hold Me - By Jordan Clark | I Am Not That Guy - By Adam Cloud | The Machine of Dr. Guillotine - Lyrics: Jerry Wayne - Music: Jeff Wayne Have a question or comment that you’d like played on the air? — Please Leave a Message at (801) Sketch1 — [(801) 753-8241]
Keeping Time With Oster Watches, Episode Twelve, features Jeremy Oster with editor and writer of the watch section of Robb Report Magazine, James Malcolmson. For 40 years, Robb Report magazine has served as the definitive authority for connoisseurs of the good life. The magazine is dedicated to providing extensive knowledge of the rare, luxury goods industry with superb insight into what is happening in the world of fine watchmaking. Join us as James enlightens us with insight and discussion on historical and current topics in the luxury watch industry.
Episode Twelve of The POC Report features Dennis, Founder of the Toy Sldrs brand.In this episode Dennis talks about his experience as an entrepreneur, the steps he took to make his 1st Strike cereal, creating his logo and so much more!Check out Toysldrs.com & Follow, follow, follow @ToySldrs on Twitter, Facebook, and Instagram.Music Credits Cutty @QuincyGotRich ft. Derek Wize Kanye's Lexus - @skipper-jones ft. Damingo Brown Closing Credits Looƨe - @amaresymone Keep up with the show by following the hashtag #POCR.Follow The POC Report on Twitter - @ThePOCReport Follow Indie Creative Network on Twitter - @IndieCreativeNWwww.indiecreativenetwork.com www.thepocreport.com ICN
It is only fitting that Episode Twelve, the episode to close out 2015, is all about Star Wars, the fandom that started it all for host Dan Peck, and also acted as the perfect bookends to the nerdiest year of his life. Joining Dan for this episode are panelists Greg Newman, Jill Martelli, and Mike Urbanski. … Continue reading My Nerdy Year Episode 12 – Star Wars
Episode Twelve! We talk about lots of things on this week's episode, including fireworks, perverts, white privilege and Felipe's brother getting a shitty gift for a 5 year old. Please take 5 seconds to rate or review the podcast on itunes and if you like it subscribe! Thanks for listening! LINKS Felipe Esparza: FACEBOOK: www.Facebook.com/FelipeEsparzaFanPage TWITTER: @FunnyFelipe INSTAGRAM: @FelipeEsparzaComedian www.felipesworld.com Lesa Esparza TWITTER: @LesaInLA INSTAGRAM: @LesaInLA
Episode Twelve meet Colleen Morrissey. Colleen got started as a go-go dancer and cocktail server. She learned to bartend by watching the bartenders flair and mix drinks and they helped her move behind the bar. She has high volume bartending experience in Atlantic City's Casino nightclub nightlife and has been doing it for 12 years.Colleen offers us a glimpse into casino style bartending and talks about the union that bartenders and servers are a part of. She has great advice for newbies in the industry and we'd love to know what you think! 'Music Credit: "Going Home" by Lee Rosevere' http://freemusicarchive.org/music/Lee_Rosevere/
Episode Twelve of Stephen Palmer's Hairy London read by RD Watson
Episode Twelve is spent discussing the state of the Record setting Golden State Warriors; Marvel vs. 20th Century Fox Super Hero projects; Mel Brooks and Spaceballs 2 talk; OJ Simpson trial vs. TV show. Shout out to Arturo Ruvalcaba for the new logo!
Episode Twelve features music from an up-and-comer named Laurenn Marchand from Cape Breton, the new single from Wintersleep, The Once, Radio Radio, Carelton Stone, Hillsburn, and we even get a bit nostalgic with our boys in the Trews.
The crew takes a job that ends up with Two being captured by the people who created her. Faced with a well-fortified facility, the crew sends in the Android to help Two escape. After Two is safely back on the ship, Five finds that someone has disabled the Android. When they realize that only one of them could have done it, the crew members begin to turn on each other. Find shownotes for “Episode Twelve” & “Episode Thirteen” — BWD14 and check out our other podcasts at ASK Genre TV.
Episode Twelve. Huzzah! Nimble forest creature Ina is our guest for the season one finale. Deadwood honors General Crook and the 7th Calvary with a parade... Otis attempts extraction from Alma's veins, but submits to the righteous fury of Seth Bullock... Stapleton's reign as sheriff ends... Doc pleads for mercy on behalf of the reverend... Al solves the magistrate conundrum (please ignore the bloodstain that mysteriously appeared)... "Salma" finally happens, and it's amazing. ... Also, Christiana reveals the peculiarities of the Negro race. | Send feedback to hooplecast@gmail.com. Find our recording schedule, show notes, discussion threads, and more at hooplecast.com. | Recorded July 12, 2015. Released July 17, 2015. [Warning: Explicit Language.]
Episode Twelve - 2015 Season
Join comedians Rachel Fairburn and Kiri Pritchard - McLean as they explore a shared passion, serial killers. Each episode the pair will talk all things murder and macabre and have a right laugh doing it. Episode Twelve looks at Ivan Milat, the Backpack Murderer. The hero of the piece? A man called Paul Onions. It's worth listening just for that.
EPISODE TWELVE. BLOODY MULLETS AND ALL… Apologies for the increasingly usual delay. But we hope you agree that Episode 12 – packed full of such delights as good poshos, bad poshos, fakery, wonderful character actors, wigs, tofu burgers, anal fins and numskull Eric Catpole barking like a dog – was in some way worth the […]
Multiple Sclerosis Discovery: The Podcast of the MS Discovery Forum
[intro music] Host – Dan Keller Hello, and welcome to Episode Twelve of Multiple Sclerosis Discovery, the podcast of the MS Discovery Forum. I’m your host, Dan Keller. This week’s podcast features an interview with Professor Gavin Giovannoni about the potential for finding a cure for MS. But to begin, here’s a brief summary of some of the latest developments on the MS Discovery Forum at msdiscovery.org. Monocytes and microglia are hard to tell apart and as a result, their roles are poorly understood in MS. But we recently covered a paper that demonstrated separate roles for these macrophages in EAE. Using fluorescent tags, the researchers were able to determine that monocytes were directly attacking the myelin. Meanwhile, microglia arrived to the same area of myelin attack only to be shut down. The paper has major implications for future methods in studying MS as well as for the mechanisms of the disease itself. We published another data visualization recently, titled the “MS Galaxy.” The visualization shows 250 authors of phase 3 clinical trials in MS, and how they are connected to each other. You can explore the galaxy by visiting msdiscovery.org and visiting the data visualizations section under the “research resources” tab. Additionally, we published a different sort of visualization. This one is an animated video that synthesizes the current understanding of MS immunopathogenesis. Often in presentations, immunologists will toss up a confusing slide covered in shapes, arrows, and acronyms. ACTRIMS’ president, Dr. Suhayl Dhib-Jalbut, has taken that slide and broken it down into its component parts. It’s a wonderfully illuminating experience to listen to him go through the slide step-by-step. MSDF worked in collaboration with Dr. Dhib-Jalbut to make the video. You can view it in the data visualizations section of our website. [transition music] Now to the interview. Professor Gavin Giovannoni from Queen Mary University in London is one of the world’s most prolific and most visible MS researchers and clinicians. He is also on the scientific advisory board of MSDF. I met with him at the university to discuss the potential of a cure for MS. This is part one of the interview. Next week’s podcast will feature part two, in which Professor G, as he’s known, discusses the role of Epstein-Barr virus in MS. Interviewer – Dan Keller Professor Giovannoni, let’s talk about the possibility of cure of MS. I suppose the first question would be what would you define as a cure? Interviewee – Gavin Giovannoni Because MS is considered to be an autoimmune disease, we should really be able to destroy the autoimmunity by replacing the immune system, or rebooting the immune system, that’s the concept. And there are certain drugs that do that. Obviously, the most aggressive would be bone marrow transplantation, this autologous bone marrow transplantation. And the other one is a recent drug we’ve been using, alemtuzumab, which is a drug that targets leukocytes and depletes them and allows the immune system to repopulate, and when repopulated comes back clearly in a different way. And hopefully those two strategies will remove the autoimmunity. And those two strategies are very effective. A significant proportion of the people who are treated with bone marrow transplantation or alemtuzumab go into long-term remission; I’m talking about remission 10, 12, 15 years in some of these patients. And if you follow these people up, there’s no evidence of inflammatory activity, so they don’t have relapses. And you monitor their MRI scans, you don’t see any new lesions; the lesions that are there are stable, scarred lesions. And also if you monitor the end-organ brain atrophy rates are not accelerated, their brains are shrinking in the same range as in normal aging. You know, looking at it at a superficial level, we can’t find any evidence of active MS. Now the question is are those people just in long-term remission or are they cured? And so the definition of a cure then is how long would you follow these people up and say, alright, your MS has gone away. We’ve been debating this in the field for a while. And we think a reasonable definition would be 15 years after they’ve had the treatment, and that would give us sufficient time to study a population and compare them to what we would expect to happen in a natural history study or other treatments. And it’s looking like a significant number of these people are staying in long, long-term remission. So I’m hoping that a portion of them will be cured of the disease. MSDF Now these are autologous bone marrow transplants? Dr. Giovannoni Yes. MSDF So what would prevent them from re-reacting to whatever caused their problem in the first place? I can see allogeneic transplant, you would have a sort of non-susceptible population of cells. Dr. Giovannoni Yes. I mean, we don’t really know the pathogenesis of autoimmunity in the sense where’s it driven from. I mean, there’s lots of epidemiological evidence in the MS field it probably starts in utero, actually. There’s evidence for parental origin, and migration studies, and monthly birth defect, etc., to suggest that something’s happening in utero. And there’s probably something happening in early life that imprints the autoimmune phenotype or the susceptibility to get autoimmunity. And then, obviously, there’s some trigger that occurs that happens later in life. And I would imagine that that rebooted immune system that we say the autoimmunity is gone would probably still be susceptible because you’re repopulating from a susceptible background, but maybe that trigger won’t come again. I mean, one of the things people have got to realize is we’re not trying to say this is a cure in everybody who gets this treatment, it’ll only be a proportion of people, and those are the people who don’t reactivate. I mean, we need to learn a lesson is what’s triggering their reactivations if they’ve been in long-term remission. Is it an environmental agent, infection, or something like that? So I wish one knew where the autoimmunity is being triggered from, we don’t know. MSDF What sort of experiments are going on now? Is this just registries, or do you have multiple strategies? It seems like you have to do very, very long-term follow-up. Dr. Giovannoni Alemtuzumab was developed in Cambridge and they’ve been using the drug now since 1992, and they’ve got an open-label extension study that they’ve been following up, and they’ve just published a 12-year follow-up data about a month ago in the JNNP. And of that open-label study, about just over 50% of the population are stable. Then there’s obviously the clinical trial programs, and there have been relatively large phase 2 and two phase 3, and those have all gone into open-label extension and those people will be followed up indefinitely, and we’ll probably get data from that. The bone marrow transplant, it’s a little bit more complicated because most of the development has been done by academic units, so there are registers. And there is a larger phase 3-type study happening in the US at the moment. The registers follow these patients up long-term, so we’ll see what happens. But the cohorts that have been treated early with the disease are doing extremely well. The majority of them, provided they get through the bone marrow transplant, their disease goes into remission and their brain atrophy rates after year 1 are within the normal range, no relapses at MRI, no new MRI activity. So it’s looking very promising. The problem with bone marrow transplants, it’s quite a risky procedure. For some people it’s a risky procedure, for others it’s not, which is one of the things we find out. If you go to the community and you ask people with MS, when you say to them your chances of dying from the procedure – because in very good bone marrow transplant units now, the mortality rates are between 0.5 and 1% – a lot of people with MS will take those risks. I mean, it’s up to them, they’ve got the disease. The difficulty we have is which patients do you offer those aggressive therapies to. MSDF Does the feasibility of bone marrow transplantation go down with age? Dr. Giovannoni I mean, if you train in MS is that all these therapies really work early in the disease. I think the reason for that is the longer you’ve got MS, the more damage is left behind, and that primes that nervous system to degenerate. So when they’ve used bone marrow transplantation in secondary progressive disease and people have really got quite a lot of disability, the induction part of the chemotherapy – the chemotherapy itself is neurotoxic, so they tolerate the induction therapy very poorly. And although the bone marrow transplant switches off the inflammatory component of the MS, that damaged central nervous system is still there and they continue to progress. We think they may progress at a slower rate, we don’t know that, so it doesn’t really stop the secondary progressive phase of the disease when it’s been used in that, which is why most people who do bone marrow transplant now are shifting towards early MS when there’s much more to protect. And the other issue is there’s a big theory evolving in the MS field that a part of the progressive phase of the illness is premature aging. I’m not talking about premature aging across the whole body, but premature aging within the central nervous system. We know now that any inflammatory or chronic inflammation triggers aging pathways, and that may just drive some part of the progressive component to the disease. And if that’s the case, then we’re not going to be able to modify with anti-inflammatory therapies the strategies that target aging. MSDF Is this total bone marrow ablation as you would do in any other transplant for curative purposes in oncology, or is it something less than that? Dr. Giovannoni Well, it depends who you speak to. I went into detail with this in terms of wanting to set up a bone marrow transplant program here about 15 years ago, and I opted out because the risks then were too high. So some people say you really need myeloablative therapy and some people say you don’t need as much as myeloablative; less, you know, these partially ablative ones. So there’s two schools of thought; some want to go for the aggressive and some go for the less aggressive. The Canadian group have used really aggressive induction therapy with myeloablative therapy, and they had, unfortunately, one death and some serious toxicity. So there again is a tradeoff between which one you go for, and I think the results will show over time. To be honest with you, now that we’ve got alemtuzumab which is a licensed therapy, it’s going to be hard to justify using bone marrow transplant when we’ve got a less toxic monoclonal antibody available. It’s also got safety issues, but I think those safety issues are manageable with monitoring. So I think it’s going to be very hard in the current climate to justify bone marrow transplantation when you have alemtuzumab as a licensed drug. MSDF Is chemotherapy in itself a reasonable treatment? Dr. Giovannoni They’ve been tried in the past. I mean, the mistakes we made would say cyclophosphamide, which is an alkylating agent, is that when the trials were done we did them in an era when we didn’t know how to do MS trials. So they were done prior to MRI monitoring, they tended to be doing advanced MS, and the trials were underpowered. I think if we had to do cyclophosphamide in the modern era, we would have done the trials differently, and I’m almost certain they would be effective. We have mitoxantrone which is a chemotherapy agent; that’s got a license in quite a few countries. It’s unfortunately a topoisomerase inhibitor and it’s associated with translocations and causes leukemia. And that’s pretty common actually. The registries that have been tracking are reporting the incidence of mitoxantrone-related leukemia at about 1:150 to 1:200, and I think that itself takes that drug out of practice, to be honest with you. And it also is dose-related treatment; you can only give it for a certain number of infusions because it causes a cardiomyopathy, and it’s also linked to premature ovarian failure. There’s a lot of the issues about using that drug in clinical practice, and most centers now have stopped using mitoxantrone. MSDF Does this lead into the idea of aborting MS so you don’t get into a progressive phase, all these strategies? Dr. Giovannoni Yes. We all talk about secondary progressive disease. I’ve stopped using the term secondary progressive disease in isolation. I say clinically progressive disease because the progressive phase of this illness is present from the very beginning of this disease. So when people present with their very first clinical attack, a significant number then will already have had brain atrophy and cognitive impairment. And if you monitor people at every stage of the disease, there’s this progressive brain atrophy occurring. So we think the pathological substrate for progression is there from the outset. What makes somebody transition into the progressive stage clinically is when the brain reserve runs out. So what stops the progressive phase manifesting is the fact that we’ve got reserve capacity and we compensate. And once that’s run out, people enter the clinically progressive phase of the disease. So I talk about progression being there from the outset; at some point in time you’ll present with secondary progressive MS, and I think it’s system-related. This is one of the other concepts I’m trying to get across is that progressive disease is not just progressive disease. I mean, most people present initially with the motor system and the lower limbs or their bladder involvement, and then it gradually spreads to their arms, their cerebellar systems, etc. I call it asynchronous progressive disease, and I do this because I really want to give people with progressive MS hope that if you’ve got progression in one pathway, we may be able to treat you and prevent it from becoming clinically progressive in the other pathways. So this is where we need to rethink our trials, because all of our outcome measures in clinical trials are based purely on lower limb function and mobility. If we wait for people to become progressive in that system, then use that system as a readout, we might miss an important therapy. So what we probably should do is say, well that system’s in the progressive phase, let’s focus on preventing the other systems from entering the progressive phase, those systems that have got reserve capacity. If we change our thinking like that, we’ve got a much greater chance of getting a drug licensed for progressive disease than we have at the moment. MSDF Because you can choose various endpoints to look at and show that it’s having some effect somewhere? Dr. Giovannoni Yes. The idea would be to stop or prevent people entering the progressive phase in the other systems. Once somebody’s in the clinically progressive phase in a particular neuronal system, it means that they’ve lost reserve capacity. And that reserve capacity is what predicts recovery. So somebody who is really progressing along that pathway is extremely vulnerable and probably prime to continue to progress. That’s going to be very difficult to show an effect in that pathway. And that’s what we’re doing right now. We’re saying let’s take people with progressive MS that are having walking difficulties, let’s put them in a trial and try and slow down that walking problem. And I think that’s the wrong strategy. I think we should be changing our way we do trials. MSDF My impression has been that when someone enters the secondary progressive phase, there seems to be an acceleration. But from what you say about loss of reserve leading to progression, it sounds like it’s just the same slope but without the remissions. Dr. Giovannoni Yes. We think the mechanisms are different though. There is some evidence what I call a therapeutic lag. This is complicated. Let me explain what a therapeutic lag is. When you’re in the progressive phase of the disease, we think the progression that’s occurring this year or next year has been primed by inflammation that’s occurred over the two years. So there’s a lag between the inflammatory component which damages those nerve fibers, and then they dive over the next few years. It probably damages them and they’re probably surviving and functioning but compromised, and that process then runs its course. So I think what we really need to do is if we do clinical trials and switch off inflammation now, you’re not going to see an effect of an anti-inflammatory drug in the next two years, we have to look in year three, four, and five. And there is data now from extension studies supporting this. So I actually think we also need to change our trial design in progressive MS if you’re going to look at a progressing pathway; not to look in two years, we’ll be looking at year three, four, and five. The current crop of trials are kind of doing that. What they’ve done is instead of having a fixed time point of two years, most of them are event-driven, so when they have enough events they will stop the trial. And the event-driven trials looks like they’re taking the follow-up into year three and sometimes year four. So we may get enough power to see if that works in the current crop of trials in progressive MS. But I really do think that we need to go to probably five years in progressive MS trials to get a readout that we can trust, based on our understanding of the progression of the disease. MSDF So can you enumerate or summarize what you think trials should look like? What one would choose as endpoints, definitions, anything else that would be different from how they’re doing it today? Dr. Giovannoni Yes. So if we’re going to continue to use the gold standard, which is EDSS, this expanded disability status goal which has a lot of psychometric problems – it’s got a flawed seeding effect, it’s not linear, it’s got a high inter-rater. . – with all those problems, we’ve still got this damn gold standard, EDSS. If we’re going to use the EDSS and we’re going to focus on mobility, then we’re going to have to do 5-year trials. And know that there’s a therapeutic lag, forget about expecting to see a result in year two and look at year three, four, and five. In addition to that, I think we need to actually then develop new outcome measures that assesses the systems that aren’t affected, like upper limb function, cognition, cerebellar, eye movements, etc., and look for differences in those systems on active treatment versus placebo. We’ve changed the question. In other words, we’re trying to prevent those systems from being damaged relative to the system that is damaged. And I think then we may get an answer. And I’m almost certain anti-inflammatory strategies that I’ve been told not to work in progressive MS will work. MSDF If you look long enough. Dr. Giovannoni If we look long enough or we change the way we define the outcomes. Because I do think that those other systems that aren’t progressing clinically will be more responsive in a shorter period of time; they’ve still got reserve capacity. And that reserve capacity really predicts recovery. We’ve seen this now in early MS is if somebody has got a low disability score and you treat them with a powerful anti-inflammatory, be it natalizumab or alemtuzumab, a significant number – 30 to 40% - actually improve in function. And that’s because they’ve got reserve capacity; they have the ability to recover function. I think if you can choose pathways that have got reserve capacity and you treat with anti-inflammatories, those pathways may have an ability to recover or improve, and you’ll see the difference between the treatments much earlier. It’s just an observation that needs to be taken into clinical trials. MSDF Locking the barn door while the horse is still in. Dr. Giovannoni Yes. This is like any other disease. There’s no point in treating a disease after you’ve missed the boat. If you speak to rheumatologists or nephrologists, it’s much better to protect the kidney and the joints before they’re damaged. The same concept needs to come into the MS field. You need to target the organ before it’s damaged, because prevention is much better than trying to promote recovery. MSDF Very good. We appreciate it. Thank you. [transition music] MSDF Thank you for listening to Episode Twelve of Multiple Sclerosis Discovery. This podcast was produced by the MS Discovery Forum, MSDF, the premier source of independent news and information on MS research. MSDF’s executive editor is Robert Finn. Msdiscovery.org is part of the non-profit Accelerated Cure Project for Multiple Sclerosis. Robert McBurney is our President and CEO, and Hollie Schmidt is vice president of scientific operations. Msdiscovery.org aims to focus attention on what is known and not yet known about the causes of MS and related conditions, their pathological mechanisms, and potential ways to intervene. By communicating this information in a way that builds bridges among different disciplines, we hope to open new routes toward significant clinical advances. We’re interested in your opinions. Please join the discussion on one of our online forums or send comments, criticisms, and suggestions to editor@msdiscovery.org. [outro music]
Episode Twelve. Kaitlin and Kyle. They met at a kissing booth. On their first date they went on a recording adventure (for one of the early Audio Smut documentaries about the Drag Queens). They became obsessed with each other. They ended up making audio recordings of a lot of almost everything that happened between them. This is the last episode of the season. It is also the last episode of Audio Smut. Don’t cry! We will be starting something new in a few months, better and more beautiful than ever before.
Unable to reason with Vayne, Nell is thrown in a dungeon cell as an act of absolute control of Dalmest Kingdom and its people. Recalling his childhood memories, Nell is plagued by his past choices as a leader. On the outside, the Salem and Amelia have taken action within the castle to save their trapped friend.
Episode TWELVE is dedicated to the 12th Man. Not only do we get to discuss one of the Seahawks most impressive victories this season against the Cardinals, we bring on a former member of the Seattle Seahawks. Adam and Brandan also talk about the upcoming road game against the Rams. Adam says that a "and hurricane" can't even save the Rams from a loss this week. Joe Tafoya, a 7-year veteran of the NFL and defensive end for the Seahawks from 2005-2006, joins the Sea Hawkers Podcast to talk about Volume 12. As co-owner of Volume 12, he led the effort behind the record breaking attempt for the loudest crowd roar against the San Francisco 49ers. One thing is clear, Tafoya is not impressed with the way the Kansas City Chiefs broke the Seahawks noise record. Instead of having the crowd roar be an organic part of the game, he says that Chiefs fans were directed to assemble what fans were remaining in the stadium and let out one big cheer in one final attempt to break Seattle's mark. In the final segment of the show, Brandan lists some of the top moments in the history of the 12th Man. The show is capped by the Seahawks fans at the Arizona game earning well-deserved recognition for being Better at life than Skip Bayless and also louder than the Cardinals own home crowd.
Welcome to Episode Twelve of The Epic Questions Podcast!! Today is Sunday April 7, 2013. We've got questions about hunters, pre-raid warm ups, dwarfs, podcasts, leveling, and much more. Don2019t worry we won2019t be roasting any gnomes this week or slaughter any critters. So grab a glass of noggenfogger, take a seat in your farm house, and enjoy the show.
Dex has trouble focussing on the present and becomes increasingly frustrated by his inability to crack the case. Episode Twenlve The post Episode Twelve appeared first on M. Darusha Wehm.
We return with a full length special edition:Episode TwelveThis week, we present a full blown international episode, with supplements from all over the globe. Well, two places on the globe.
Welcome to Episode Twelve of the Community Animal Rescue Effort Pawdcast! Your source for all that wags, sniffs, barks and meows at the Evanston Animal Shelter. In this episode we’ll give you some... C.A.R.E. is an all volunteer organization that works in conjunction with Evanston's municipal Animal Shelter to find homes for the abused and abandoned animals that are brought to the shelter. This monthly Pawdcast is your source for all that wags, sniffs, barks and meows at the Evanston Animal Shelter.
Episode Twelve of the continuing serial. Verity's mother notices something's wrong.Theme music is "Faithful" by The Shillas.Promo for Voice of Free Planet X.Get the first episode of this serial here.Direct Download
Finally, the Last Episode of Season One of br/>the Infamous Jackson Bros! Another great episode, br/>in which we review: br/> br/>Three Batman-centric fan films: One from Smiegiel Pictures, a href="http://www.freewebs.com/smigielpictures/filmsandvideos.htm">Batman: Dark Descent /a> ; br/>a film from Budgetless Productions a href="http://www.fanfilms.net/index.php%253Fcid%253D119%2526fid%253D620">Law and Order: Gotham /a>; br/> a href="http://www.fanfilms.net/index.php%253Fcid%253D35%2526fid%253D901">the Lost Batman Beyond Fan Film /a> from Valentine Productions, and br/> a href="http://www.fanfilms.net/index.php%253Fcid%253D125%2526fid%253D943">The Flash: Speeding Ticket /a>from Blinky 500 Productions! br/> br/>Thanks for all the support in our First Season! br/>Be sure to check out our DVD Release for the first season, featuring many br/>Bonus features, as well as a LOST episode!! br/> br/>We’ll be taking a short break and will be in repeats until the second season br/>starts in January 2008! Be sure to check out a href="http://www.iblac.com/">iBlac /a>, our sister show on br/> a href="http://www.creoleentertainment.com/">www.creoleentertainment.com /a>! br/>And be sure to check out our AppleTV feeds also in iTunes!
Second Shift: An original fantasy Podplay (high-quality audio version)
Episode Twelve of Second Shift, "The Last Home You WIll Ever Know, Part One: Flight"
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