Podcasts about flavivirus

TWiV reviews polio vaccination campaign in Gaza, viruses with zoonotic potential in farmed fur animals, low HPV vaccination in North Texas associated with high rates of cervical cancer, a large flavivirus genome that does not encode error correction machinery, and antiphage defense through inhibition of virion assembly. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Jolene Ramsey Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Polio vaccination in Gaza (Reuters) Zoonotic viruses in farmed fur animals (Nature) HPV vaccination and cancer rates (JAMA Net Open) 40 kb RNA genome without error correction (PNAS) Stopping the phage tape measure protein (Nat Commun) Tail assembly interference (Nat Commun) Letters read on TWiV 1151 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Digital nature pics winners 2024 Wildlife Photographer of the Year Alan – Adorable story about a Nigerian paralympian couple who are both polio survivors Jolene – Capsid assembly model with self-assembling pentamers in 3D print model (plus three more models now available if search self assembling virus) and Wonderlab article about exhibit using this to teach about viral patterns in Bloomington Indiana Science museum Vincent – The collapse of bat populations led to more than a thousand infant deaths Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

TWiV discusses secret anti-vax campaign run by Pentagon to undermine China during pandemic, NY governor's subways mask ban proposal, Colorado bat facility sparks outbreak fears, House budget billls suggest ban on gain of function research, evolution of STAT2 resistance to flavivirus NS5, and brainwide silencing of prion protein by AAV-mediated delivery of an epigenetic editor. Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Pentagan anti-vac campaign to undermine China (Reuters) NY governor subway mask ban (AP News) Colorado bat facility sparks outbreak fears (Science) House NIH budget bans gain of function research (Science) Evolution of STAT2 resistance to flavivirus NS5 (Nat Commun) Brainwide silencing of prion protein by AAV delivered epigenetic editor (Science) Letters read on TWiV 1127 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Mars Odyssey Orbiter is about to make its 100,000th orbit Alan – Local animal shelters and “kitten season.” Vincent – Supreme Court allows cities to ban homeless people sleeping outside, even when shelter space is lacking Listener Picks Blog design – Trump vows to defund schools requiring vaccines for students Jon – Detections of highly pathogenic avian influenza in mammals Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.09.527854v1?rss=1 Authors: Kaur, G., Pant, P., Bhagat, R., Seth, P. Abstract: Neurotropic viruses can cross the otherwise dynamically regulated blood-brain barrier (BBB) and affect the brain cells. Zika virus (ZIKV) is an enveloped neurotropic Flavivirus known to cause severe neurological complications, such as encephalitis and foetal microcephaly. In the present study, we used human brain microvascular endothelial cells (hBMECs) and human progenitor derived astrocytes to form a physiologically relevant BBB model. We used this model to investigate the effects of ZIKV envelope (E) protein on properties of cells comprising the BBB. E protein is the principal viral protein involved in interaction with host cell surface receptors, facilitating the viral entry. Our findings show that ZIKV E protein results in activation of both hBMECs and astrocytes. hBMECs showed reduced expression of endothelial junction proteins - ZO-1, Occludin and VE-Cadherin, which are crucial in establishing and maintaining the BBB. As a result, ZIKV E protein triggered alteration in BBB integrity and permeability. We also found upregulation of genes involved in leukocyte recruitment along with increased proinflammatory chemokines and cytokines upon exposure to E protein. Furthermore, E protein resulted in astrogliosis as seen by increased expression of GFAP and Vimentin. Both BBB cell types exhibited inflammatory response following exposure to E protein which may influence viral access into the central nervous system (CNS), resulting in infection of other CNS cells. Overall, our study provides valuable insights into the transient changes that occur at the site of BBB upon ZIKV infection. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Janet Smith, a professor at the University of Michigan Medical School, associate director of the UM Life Sciences Institute and scientific director of the GM/CA beamlines at the Argonne synchrotron, won the 2022 Mildred Cohn Award in Biological Chemistry, which honors scientists at all stages of their careers who have made substantial advances in understanding biological chemistry using innovative physical approaches. She presented her award lecture, "Flavivirus NS1: Structure and function of an enigmatic virulence factor," on Monday, April 4, at the 2022 ASBMB Annual Meeting, held in conjunction with Experimental Biology in Philadelphia. Learn more about her work: https://www.asbmb.org/asbmb-today/people/121721/smith-unravels-secrets-of-nature-s-catalysts.

TWiV reviews the FDA decision to update COVID-19 vaccine boosters in the fall, the meaning of fatigue with respect to long COVID, and a skin volatile induced by flavivirus reproduction that attracts mosquitoes to the infected host. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 vaccine booster composition (FDA) Settling in for the long haul (Crooked Timber) Flavivirus-induced skin volatile attracts mosquitoes (Cell) Letters read on TWiV 919 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Redactle Kathy – Kirigami paper replacing plastic bubble wrap Rich – First Images from the James Webb Space Telescope (Gravitational lens; Einstein ring) Vincent – Spotted lanternfly Listener Picks Ann – NASA Engineer Who Made the James Webb Space Telescope Work Sonrisa – Aloft – the pleasures and risks of flying Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Marta Giovanetti, Reference Laboratory of Flavivirus, Oswaldo Cruz Foundation, Rio de Janeiro, BRAZIL speaks on "Tracking the spread of emerging and re-emerging viral pathogens".

Welcome back to the first episode of Wavelength for this year! We have a brand new Executive Producer and Host, the beautiful Jamie and Cass debuts hosting for the first time, we also have an entirely new crew. We miss you David and Hamish, but alas new year, new show.   With Fringe and Adelaide's festival season in full swing, our episode is very on brand, Cass and Alex speak with Libby Trainor Parker from endo days and Carla Mattiazzo about their recent fringe shows, as well as stigmas about women's health. With more than 11% of the Australian population suffering with Endometriosis at some point during their life, it is vital to have conversations about how to seek help.   One of our newest journalists Amber spoke with James Templecock about the upcoming state election. For new time voters and veterans to the polling booth voting can be a stressful time, especially in an ever-changing covid environment. Amber goes through the basics of how to vote, where to vote, what to do if you have covid or are in isolation and how to find a party that suits you the best. The most important thing is to GO VOTE, make your voice heard.   We debut a new segment called wavo explains! This will explain a topical issue in a condensed version to make it easier to understand, this week we have Amber talking about the Flavivirus in South Australia. And Jamie goes through what the hell happened this week, including dancing being back, the rise in petrol prices and the new strain of omicron, an alien invasion isn't looking too far fetched anymore..   Listen to Wavelength live and join the convos about Adelaide you should be having, every Monday night from 6pm on Fresh 92.7. Airdate: March 14, 2022 Reporters: Jamie Alexander, Cassie Johns, Amber Young, Alex Newman Photo: Unsplash See omnystudio.com/listener for privacy information.

(00:31):But before we get started, Dr. Pritt, could you provide our listeners with a little bit about you and your background? (01:22):Can you provide a brief overview and intended use of this testing? (03:16):Could you describe what clinical action is enabled by the results of this test? (05:31):Now let's discuss which patients should have this testing and when should it be performed?' (06:56):Can you now explain, how does this test improve upon previous testing approaches? (08:04):Are there other options on the market? If so, what makes our testing different or unique?

Eva Harris and Janet Smith join TWiV to discuss how an antibody against dengue virus NS1 protein blocks endothelial dysfunction and the potential of treating infections by multiple flaviviruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guest: Eva Harris and Janet Smith Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Eva Harris on TWiV 228 Zika virus in Nicaragua (virology blog) How an antibody block NS1-mediated endothelial dysfunction (Science) Broadly protective antibody against NS1 (Science) Letters read on TWiV 725 Timestamps by Jolene. Thanks! Weekly Picks Alan – Science Photographer of the Year Awards Rich – Bar Keeper’s Friend Kathy – Perseverance secret message and other Easter eggs, 11 million Earthlings’ names, “Name the Rover” essay contest. Sign up to send your name on a future Mars mission. Vincent – COVID-19 dataset Listener Picks Matthew - Remembering the colleagues we lost to COVID-19 Lori - Iceberger Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Eva Harris and Janet Smith join TWiV to discuss how an antibody against dengue virus NS1 protein blocks endothelial dysfunction and the potential of treating infections by multiple flaviviruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guest: Eva Harris and Janet Smith Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Eva Harris on TWiV 228 Zika virus in Nicaragua (virology blog) How an antibody block NS1-mediated endothelial dysfunction (Science) Broadly protective antibody against NS1 (Science) Letters read on TWiV 725 Timestamps by Jolene. Thanks! Weekly Picks Alan – Science Photographer of the Year Awards Rich – Bar Keeper’s Friend Kathy – Perseverance secret message and other Easter eggs, 11 million Earthlings’ names, “Name the Rover” essay contest. Sign up to send your name on a future Mars mission. Vincent – COVID-19 dataset Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

From the 2020 online meeting of the American Society for Tropical Medicine and Hygiene, Vincent speaks with Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira about their careers and their research on arthropod-borne viruses. Host: Vincent Racaniello Guests: Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode RNAi in arbovirus-vector interactions (Viruses) Arbovirus emergence via bridge vectors (Sci Rep) Rift Valley fever (Trop Med Inf Dis) Flavivirus infection and cerebrovascular events (Viruses) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

From the 2020 online meeting of the American Society for Tropical Medicine and Hygiene, Vincent speaks with Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira about their careers and their research on arthropod-borne viruses. Host: Vincent Racaniello Guests: Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode RNAi in arbovirus-vector interactions (Viruses) Arbovirus emergence via bridge vectors (Sci Rep) Rift Valley fever (Trop Med Inf Dis) Flavivirus infection and cerebrovascular events (Viruses) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

This episode covers flavivirus!

Según estudios de Científicos identifican mutación de Covid-19 con mayor potencial propagación. I. Una investigación de un grupo de científicos del hospital Houston Methodist (Estados Unidos) ha dado a conocer más de 5.000 secuencias genéticas del coronavirus, que ha permitido estudiar la acumulación continua de mutaciones que ha tenido el virus durante estos meses. Entre estas mutaciones, han encontrado una que puede haber hecho que el virus sea mucho más contagioso y peligroso, aunque no más letal dicen estudios científicos. Se trata de una mutación que cambia la estructura de la proteína con forma de pico en la superficie del virus, (la que permite su ingreso al organismo), que puede estar impulsando, la propagación descomunal de esa cepa, en particular por un polimorfismo que se ha relacionado con una mayor transmisión. Los especialistas esclarecen que el SARS-CoV-2, al igual que todos los coronavirus, tiene una serie de picos característicos que rodean su núcleo y que, precisamente, permite que el virus se adhiera a las células humanas. Cuando la mutación en cuestión se generó, afectó directamente a a la proteína pico que cambió el aminoácido 614 D (ácido aspártico) a G (glicina). En esta investigación, el equipo de cientificos señala que ese cambio, que modifica a tres cadenas de aminoácidos idénticas, podría mejorar la transmisibilidad del Covid-19. II. Una investigación que analizó el brote de coronavirus en Brasil encontró un vínculo entre la propagación del virus y los brotes anteriores de dengue. Esta investigación plantea la posibilidad de una respuesta inmunológica cruzada entre los serotipos Flavivirus del dengue y el SARS-CoV-2”, concluyó el estudio, en referencia a los anticuerpos del virus del dengue y al nuevo coronavirus. Dicho vínculo que indican se encontró por casualidad, plantea una relación entre la propagación del virus y los brotes anteriores de dengue, lo cual sugiere que la exposición a la enfermedad transmitida por los mosquitos puede proporcionar un cierto nivel de inmunidad contra el COVID-19. El estudio dirigido por Miguel Nicolelis, profesor de la Universidad de Duke, comparó la distribución geográfica de los casos de coronavirus con la propagación del dengue entre 2019 y 2020 en Brasil . Las áreas con menores tasas de infección por coronavirus y con un crecimiento más lento de los casos fueron los lugares que habían sufrido brotes intensos de dengue este año o el anterior, descubrió Nicolelis. III. Cifras Covid-19 32.6 millones de casos en el mundo y 989 mil personas fallecidas es la cifra más actual sobre Covid-19.

From DukeNUS Medical School, Vincent speaks with Ashley, Sheemei, Eng Eong and Dahai about their careers and their research on flaviviruses and sensing of viral RNA. Host: Vincent Racaniello Guests: Sheemei Lok, Dahai Luo, Eng Eong Ooi, and Ashley St. John Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Dengue virus and endothelial permeability (J Clin Invest) Dengue virus morphological switch (PLoS Path) Symptomatic yellow fever vaccine infections (Nat Med) RNA recognition by RIG-I and MDA5 (Nucl Acids Res) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

From DukeNUS Medical School, Vincent speaks with Ashley, Sheemei, Eng Eong and Dahai about their careers and their research on flaviviruses and sensing of viral RNA. Host: Vincent Racaniello Guests: Sheemei Lok, Dahai Luo, Eng Eong Ooi, and Ashley St. John Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Dengue virus and endothelial permeability (J Clin Invest) Dengue virus morphological switch (PLoS Path) Symptomatic yellow fever vaccine infections (Nat Med) RNA recognition by RIG-I and MDA5 (Nucl Acids Res) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Ralph Baric, Mark Heise and Nat Moorman discuss their non-profit initiative READDI, Rapidly Emerging Antiviral Drug Discovery Initiative, to start making drugs now for the next pandemic virus. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guests: Ralph Baric, Mark Heise, and Nat Moorman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode READDI.org CEPI DNDi Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Ralph Baric, Mark Heise and Nat Moorman discuss their non-profit initiative READDI, Rapidly Emerging Antiviral Drug Discovery Initiative, to start making drugs now for the next pandemic virus. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guests: Ralph Baric, Mark Heise, and Nat Moorman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode READDI.org CEPI DNDi Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Yellow Fever has been around for quite some time, originating in Africa. It is spread through mosquitos and was one of the most mysterious diseases until a group of military physicians was sent out to find out what caused it. Sound interesting? Tune in for more!ScrubCaps: A Health and Medical Podcast Every MondayVisit my Website! https://www.brainontheloose.comLeave a Review on Apple Podcasts!https://podcasts.apple.com/us/podcast/scrubcaps-a-health-and-medical-podcast/id1442030058References: https://www.cdc.gov/yellowfever/vaccine/index.html https://www.mayoclinic.org/diseases-conditions/yellow-fever/symptoms-causes/syc-20353045 https://www.who.int/news-room/fact-sheets/detail/yellow-fever https://www.cdc.gov/yellowfever/index.html Yellow Fever: 100 Years of Discovery J. Erin Staples, MD, PhD; Thomas P. Monath, MD JAMA. 2008;300(8):960-962. doi:10.1001/jama.300.8.960 Support the show (http://patreon.com/ Nathanhidajatscrubcaps)

Vincent speaks with Félix Rey about his career and his work on solving structures of a variety of viruses and the insights learned about viral membrane fusion and antibody-mediated neutralization. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Unité de Virologie Structurale Tick-borne encephalitis glycoprotein structure (Nature) HCV RNA polymerase structure (PNAS) Flavivirus structural heterogeneity (Curr Op Viral) Antibody responses to flaviviruses (EMBO Rep) Covalently linked dengue envelope dimers (Nat Comm) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent speaks with Félix Rey about his career and his work on solving structures of a variety of viruses and the insights learned about viral membrane fusion and antibody-mediated neutralization. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Unité de Virologie Structurale Tick-borne encephalitis glycoprotein structure (Nature) HCV RNA polymerase structure (PNAS) Flavivirus structural heterogeneity (Curr Op Viral) Antibody responses to flaviviruses (EMBO Rep) Covalently linked dengue envelope dimers (Nat Comm) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent travels to the University at Albany to speak with Cara, Rachel, and Alex about their careers and their work on stress granules, epitranscriptomics, and arboviruses. Host: Vincent Racaniello Guests: Cara Pager, Rachel Netzband, and Alex Ciota Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Five postdocs in North America (TWiV 194) Zika virus subverts stress granules (J Virol) DDX68 modulates miR-122 interaction with HCV RNA (Virol) (+) RNA virus epitranscriptome (Nucl Acids Res) Adaptation of Rabensburg virus to vertebrate hosts (Virol) Effects of Zika virus strain and Aedes species on vector competence (Emerg Inf Dis) Inter- and intra-host genetic variation of West Nile virus and fine-scale evolutionary pressures (Infect Genet Evol) Timestamps by Jolene. Thanks! This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.comfor more details. Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent travels to the University at Albany to speak with Cara, Rachel, and Alex about their careers and their work on stress granules, epitranscriptomics, and arboviruses. Host: Vincent Racaniello Guests: Cara Pager, Rachel Netzband, and Alex Ciota Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Five postdocs in North America (TWiV 194) Zika virus subverts stress granules (J Virol) DDX68 modulates miR-122 interaction with HCV RNA (Virol) (+) RNA virus epitranscriptome (Nucl Acids Res) Adaptation of Rabensburg virus to vertebrate hosts (Virol) Effects of Zika virus strain and Aedes species on vector competence (Emerg Inf Dis) Inter- and intra-host genetic variation of West Nile virus and fine-scale evolutionary pressures (Infect Genet Evol) Timestamps by Jolene. Thanks! This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.comfor more details. Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV team discuss the use of quantum dots to study uncoating of influenza virus in real time, and induction of endothelial dysfunction by flavivirus NS1 proteins in a tissue-specific manner. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Quantum dots to visualize influenza entry (PNAS) Quantum dots (Wikipedia) Flavivirus NS1 triggers endothelial dysfunction (Cell Rep) Image credit Letters read on TWiV 535 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Hotel Influenza Alan- Your town’s climate in 60 years Dickson- BMC Research in Progress Photo Competition Rich-  NASA's Opportunity Rover Mission on Mars Ends (landing animation) Vincent - Watch a single cell become a complex organism in six minutes Listener Pick Anne- Pathogenesis II Kickstarter Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV team discuss the use of quantum dots to study uncoating of influenza virus in real time, and induction of endothelial dysfunction by flavivirus NS1 proteins in a tissue-specific manner. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Quantum dots to visualize influenza entry (PNAS) Quantum dots (Wikipedia) Flavivirus NS1 triggers endothelial dysfunction (Cell Rep) Image credit Letters read on TWiV 535 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Hotel Influenza Alan- Your town’s climate in 60 years Dickson- BMC Research in Progress Photo Competition Rich-  NASA's Opportunity Rover Mission on Mars Ends (landing animation) Vincent - Watch a single cell become a complex organism in six minutes Listener Pick Anne- Pathogenesis II Kickstarter Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV team summarizes the discovery of Sin Nombre virus, and presents evidence that neurotropic flaviviruses can cause intestinal dysmotility syndromes after systemic infection of mice. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 Satellite Symposia Crowdfunding for EV-D68 research Outbreak (exhibit, TWiV 501) Four Corners hantavirus outbreak (Wikipedia) Death at the Corner (Atlantic) Hantavirus infection by US state (CDC) Hantavirus US cases and mortality (CDC) Hantavirus international cases (CDC) Belmont hantavirus death (NYTimes) Intestinal dysmotility following flavivirus infection of mice (Cell) Image credit Letters read on TWiV 527 Timestamps by Jolene. Thanks! Weekly Science Picks Alan - Zooming into Sagittarius A, ESO video Rich- Orbits and Ice Ages: A History of Climate Dickson- National Geographic Best Photos 2018 Kathy- HealthMap Vaccine Finder Vincent - Taylor Custom Listener Pick Neal- The Yoda of Silicon Valley Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV team summarizes the discovery of Sin Nombre virus, and presents evidence that neurotropic flaviviruses can cause intestinal dysmotility syndromes after systemic infection of mice. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 Satellite Symposia Crowdfunding for EV-D68 research Outbreak (exhibit, TWiV 501) Four Corners hantavirus outbreak (Wikipedia) Death at the Corner (Atlantic) Hantavirus infection by US state (CDC) Hantavirus US cases and mortality (CDC) Hantavirus international cases (CDC) Belmont hantavirus death (NYTimes) Intestinal dysmotility following flavivirus infection of mice (Cell) Image credit Letters read on TWiV 527 Timestamps by Jolene. Thanks! Weekly Science Picks Alan - Zooming into Sagittarius A, ESO video Rich- Orbits and Ice Ages: A History of Climate Dickson- National Geographic Best Photos 2018 Kathy- HealthMap Vaccine Finder Vincent - Taylor Custom Listener Pick Neal- The Yoda of Silicon Valley Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

This interview stars Mafalda Farelo, a cellular biologist currently doing her PhD on faviviruses, specifically the Zika virus. We talk about the famous Zika scare from last year, its effect on Neurogenesis and why pregnant women need to be careful. We also discuss other falviviruses such as dengue and west nile.  Lastly we talk about the current research and how scientists are attempting to combat the spreading of these viruses.   Contact Mafalda on instagram: @thelabnotebook or by email at mafaldaarrabida@gmail.com   Further reading on Zika and Neurogenesis https://www.ncbi.nlm.nih.gov/pubmed/29116029 https://www.ncbi.nlm.nih.gov/pubmed/28826723 https://www.ncbi.nlm.nih.gov/pubmed/28370966   Any other questions?  Let us know!  We appreciate your feedback. You can now support the podcast at https://www.patreon.com/sfspodcast.  Many thanks to our past and present supporters!  Thanks to Plant Warrior for their support.  Use discount code SFS10 at checkout for 10% off your purchase of plant-based protein.

In the first episode for 2018, the TWiV team reviews the amazing virology stories of 2017. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Become a patron of TWiV! Links for this episode ASV 2018: asv.org, asv2018.umd.edu Virology stories of 2017 - in no particular order A virologist in space - TWiV 444 Cool things viruses do:  Astrovirus capsids are enterotoxins TWiV 423; giant Klosneuviruses encode lots of stuff for translation TWiV 437; Giant Noumeaviruses quickly make the nucleus temporarily leaky TWiV 440 TWiV 438 Drs. TWiV go to Washington and the March for Science Unexpected stuff: TWiV 451 Expectorate the unexpected; TWiV 470 Just a passing phage; TWiV 456 Be careful of canons; TWiV 455 Pork and genes; TWiV 432 gamete fusion protein from viruses TWiV 443 On a leaf no one can hear you scream. The puppet master. TWiV 448 Mavis the structure maven Viruses are us: TWiV 472 Riddle of the skinks; TWiV 439 The purloined envelope; TWiV 434 Live long and pupate Antiviral RNA: TWiV 433 Poops viruses and worms; TWiV 449 The sound of non-silencing; TWiV 450 Ben tenOever and RNA out Viruses as tools: TWiV 461 Gotta trace them all Flaviviruses: TWiV 473, 471, 468; 458; 454; 451; 432; 430; 429; 426 NSF survey of earned doctorates Letters read on TWiV 475 Weekly Science Picks Kathy - Voyager recording and book Rich - David Sheldrick Wildlife Trust (Maktao) Dickson - Global Croplands Map Alan - The Great Influenza one day at a time Vincent - The Doomsday Machine by Daniel Ellsberg Listener Picks Mark - Science Moms and Science of HIV Andy - Ask Me Anything Steve - Critical Attitude in Medicine Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The Fellowship of the Virus discuss enhancement of dengue disease in humans: the contribution of antibody concentration and increased binding to Fc receptors. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASV 2018: asv.org, asv2018.umd.edu Support Microbe.tv NEIDL is approved NIH lifts GOF moratorium (Science) Blackburn steps down as head of Salk Institute (SD Union Trib) ADE of dengue disease in humans (Science) Commentary on ADE of dengue disease (Science) ADE of dengue disease and antibody binding to Fc (Science) Letters read on TWiV 473 Weekly Science Picks Kathy - Today in Science History Dickson - 10 Breakthrough Technologies 2017 Rich - SpaceX to orbit a Tesla Alan - Debt in America Vincent - The Death of Expertise by Tom Nichols  (NYTimes review) Listener Picks Stephen - A Concise Paper Johnye - Holiday song parodies (one, two, three) Tom - SMBC: Are viruses alive? Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiVerinos discuss restriction of dengue virus vaccine by Sanofi, and data which suggest that Dengvaxia causes enhanced disease in previously uninfected recipients. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASV 2018: asv.org, asv2018.umd.edu Sanofi update on Dengvaxia Trouble for dengue vaccine (Reuters) Sanofi restricts dengue vaccine (CIDRAP) Dengvaxia enhances disease (Vaccine) Interview with Jeff Almond Dengue vaccine on TWiV 319, TWiV 370, TWIV 384 Image credit Letters read on TWiV 471 Weekly Science Picks Kathy - NASA is reinventing the wheel Dickson - Stunning neuroscience images Rich - Moneyball by Michael Lewis (film) Alan - Diverse Sources Vincent - Zombie gene protects elephants from cancer (Quanta, TWiEVO) Listener Picks Scott - Why Vaccines Matter by Cynthia Gorney and The Song of the Dodo by David Quammen. Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiVians present an imported case of yellow fever in New York City, and explain how a dengue virus subgenomic RNA disrupts immunity in mosquito salivary glands to increase virus replication. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Conference on Viral Manipulation of Nuclear Processes Roger W. Hendrix, 74 (Pittsburgh Post-Gazette) Roger Hendrix video on TWiV #135 Yellow fever in traveler returning from Peru (MMWR) Dengue subgenomic RNA in mosquito salivary gland (PLoS Path) Image credit Letters read on TWiV 458 This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com Weekly Science Picks Kathy - Antibody validation Editorial Asilomar meeting report Dickson - Despommierphotoart.com Alan - NOAA Hurricane Hunters Rich - Awakenings by Oliver Sacks (encephalitis lethargica) Vincent - Goodnight Lab by Chris Ferrie Listener Picks Pete - Change Agent by Daniel Suarez Paul - Pasteur's Gambit by Stephen Dando-Collins Maureen - Discovery Documentary First in Human Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV scientists reveal that mosquitoes transmit different West Nile virus populations with each blood meal, only to have the diversity purged in a bird host. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler   Become a patron of TWiV! Links for this episode Driving past a milestone (TWiP 100) Debug Fresno (Verily blog) What could possibly go wrong? (TWiV 388) Chestnut blight (ProMedMail) Hypovirus molecular biology (Adv Virus Res) Mosquitoes transmit unique WNV populations (Cell Rep) Teaching science using pseudoscience Image credit Letters read on TWiV 451 Weekly Science Picks Kathy - Approaching Jupiter and Michigan parents about vaccination Rich - Math Limericks from Futility Closet Alan - NASA flyover of Pluto Vincent - Talk show host nominated as USDA chief scientist Listener Pick Neil - These smart girls are here to debunk anti-vaxxer nonsense John - John Sever AMA Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

From Nido2017 in Kansas City, Vincent  meets up with three virologists to talk about their careers and their work on nidoviruses. Host: Vincent Racaniello Guests: Margo Brinton, Luis Enjuanes, and Linda Saif Become a patron of TWiV! Links for this episode Murine flavivirus resistance gene (PNAS) TIA-1/TIAR binding sites in West Nile virus RNA (J Virol) Infectious coronavirus DNA in BAC (PNAS) Norovirus binding to lettuce (Appl Env Micro) This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Host: Vincent Racaniello Guests: Ralph Baric, Kristina De Paris, Tal Kafri, Helen Lazear, Mark Heise, and David Margolis In the second of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on RNA viruses, and what they would be doing if they were not scientists.   View video of this episode at YouTube Become a patron of TWiV! This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100. Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit From the twiVivants, follow up on FluMist and Zoster vaccines, Zika virus update, and isolation of a multicomponent animal virus from mosquitoes.   Become a patron of TWiV! Links for this episode FluMist problem (FDA) DA Henderson obituary (NY Times) DA Henderson, smallpox eradicator (TWiV Special) Efficacy of VZV vaccine (Ther Adv Vaccines) Zika virus burden, Puerto Rico (JAMA) Zika virus in Miami Beach (STAT) Congenital brain anomalies and Zika virus (Radiology) Congenital Zika syndrome with arthrogryposis (BMJ) Multicomponent animal virus from mosquitoes (Cell Host Microbe) Breaking rules of infection (NPR) Image credit Letters read on TWiV 404 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100. Weekly Science Picks Alan - Sally Le PageDickson - Comfortably Numb by Jamie Dupuis Rich -  Learned HelplessnessVincent - Virus by Marilyn Roossinck Listener Picks OneTime - The Stranglers - Old CodgerSteve - A Poem About Pronunciation Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler The TWiVerati revisit possible sexual transmission of Zika virus, and reveal how a cell protein that allows hepatitis C virus replication in cell culture enhances vitamin E mediated protection against lipid peroxidation.   Become a patron of TWiV! Links for this episode Late sexual transmission of Zika virus (Lancet) Zika virus disease in US (CDC) Zika virus lab accident (ABC News) Mosquito eradication (virology blog) Florida mosquito control (TWiV 111) How tequila mosquito (TWiV 178) SEC14L2 allows HCV replication in cell culture (Nature) Lipid peroxidation (Wikipedia) HCV replicase regulated by lipid peroxidation (Nat Med) Letters read on TWiV 393 This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Also brought to you by ASV 2016 Weekly Science Picks Alan - All About That SpaceRich - The Expanse by James S.A. Corey (SyFy) Kathy - Five Pivotal Paragraphs in a PaperVincent - Agar Art Contest Winners Listener Picks Ted - Marshall Niremberg charts Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guests: Carolyn Coyne, Helen Lazear, and Jeremy Luban The TWiVziks present everything you want to know about Zika virus, including association of infection with microcephaly and Guillain-Barré syndrome, transmission, epidemiology, and much more.   Links for this episode Zika outbreak in Brazil (EID) 13:40 Zika summary (ProMedMail) 19:30 Zika and microcephaly (MMWR) 27:30 Facts about microcephaly (CDC) Brazil Ministry of Health microcephaly numbers Zika spread in Americas (MMWR) Deu Zica 42:30 Microcephaly in Brazil (Lancet) 46:10 GM mosquitoes did not start Zika outbreak (Discover) 1:31:30 Debunking myths around Zika (Mad Virologist) Sexual transmission vs sexually transmissible (virology blog) 1:22:10 CDC Zika travel guidance 1:15:45 CDC on Zika and sex 1:17:10 Image credit: Esper Kallas, University of Sao Paulo Letters read on TWiV 375 This episode is sponsored by 32nd Clinical Virology Symposium and ASM Grant Writing Webinar Weekly Science Picks 1:50:45 Alan - Jetstream Online School for WeatherVincent - New virus watercolors from Michele Banks (one, two)Rich - The Mad Virologist (Facebook, blog)Kathy - Orcas in AntarcticaJeremy - Pardis Sabeti on TEDHelen - Science ValentinesCarolyn - Three letter word missing from Zika warnings Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler For a TWiV Thanksgiving, Vincent, Alan, and Kathy trace the feud over genome editing, a new virus discovered in human blood, and the origins of hepatitis A virus. Links for this episode Battle over genome editing (Wired) 10:05 First description of CRISPR in E. coli (J Bacteriol) 14:00 Cas genes identified (Mol Micro) 14:20 CRISPR-Cas provides immunity to bacterial viruses (Science) 15:35 Cas9-crRNA complex mediates DNA cleavage (PNAS) 16:55 Dual RNA-guided DNA endonuclease in bacterial immunity (Science) 17:50 Genome engineering using CRISPR/Cas (Science) 18:50 Cpf1 endonuclease (Cell) 23:10 Classification of CRISPR/Cas systems (Nat Rev Micro) 23:50 Summit on gene editing 21:25 Novel human virus in transfusion recipients (mBio) 27:00 Origins of hepatitis A virus in small mammals (PNAS) 55:05 Image credit Letters read on TWiV 365 7:00, 1:20:35 This episode is sponsored by ASM Microbe, ASM Biodefense, and the 32nd Clinical Virology Symposium. (1:10, 1:18:30) Weekly Science Picks 1:36:30 Kathy - Tardigrade genome sequence (video)Alan - XKCD on Gates polio eradication siteVincent - Lifting the Impenetrable Veil by Charles Calisher Listener Picks Judi - Jennifer Doudna's Ted TalkRamon - Map of the Sky Send your virology questions and comments to twiv@twiv.tv

Host: Vincent Racaniello Guests: Ruth Jarrett, Glen Nemerow, and Esther Schnettler At the Glasgow Science Festival microTALKS, Vincent speaks with Ruth, Glen, and Esther about their research on viruses and Hodgkin lymphoma, adenovirus structure and entry into cells, and interactions between arthropod borne viruses and their hosts. Links for this episode Glasgow Science Festival microTALKS Hodgkin lymphoma (Histopath) HHV-6 and Hodgkin lymphoma (PLoS One) Adenovirus entry (PLoS Path) Adenovirus membrane penetration (Virology) Mosquito pathways that limit CHIK replication (PLoS Negl Trop Dis) Tick antiviral RNAi (Nucl Acids Res) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Kathy Spindler Guest: Laura Newcomb Vincent and Kathy visit Laura Newcomb at California State University San Bernardino, where they talk about Laura's viral tatoos, and a protein that protects the mosquito brain from lethal flavivirus infection. Links for this episode Neuron-specific mosquito antiviral mechanism (PLoS Path) Letters read on TWiV 338 Photos of our visit Video of this episode - view at YouTube Weekly Science Picks Laura - NP siRNA inhibits different influenza viruses (Antiviral Res)Kathy - Time-lapse miningVincent - Does the public trust science? Listener Pick of the Week Paul - Degree-Off XKCDPeter - Ebola containment, Hans Rosling, eLife podcast,  Naked Scientists Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Lee Feinman Lee joins the TWiV team to discuss the value of post-doctoral training, and how a cellular microRNA assists in the replication of hepatitis C virus. Links for this episode Spin by Robert Charles Wilson Immunization of preterm infants (Dev Period Med) miR-122 alters HCV translation-replication balance (Cell Host Micr) Holding a miR to HCV (TWiV 180) Treating hepatitis C by blocking miR-122 (virology blog) Click chemistry (Wikipedia) Image credit Ebolavirus sitrep (WHO) Letters read on TWiV 324 Weekly Science Picks Lee - Furthering America's Research and Upgoer five and sixAlan - Best snow shovelRich - Ripple tankKathy - FractalsDickson - World Press Photo Contest 2015Vincent - What to do about antivax politicians and physicians Listener Pick of the Week Patricia - Future of Bioscience Graduate & Postdoc trainingPaul - This is my son Griffin, and he may have measles Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVers review the outcomes of two recent phase 3 clinical trials of a quadrivalent dengue virus vaccine in Asia and Latin America.   Links for this episode Efficacy of dengue vaccine (NEJM) Preventing dengue (NEJM) Dengue viruses (Scitable) Intention to treat (Wikipedia) Image credit: Jean-Yves Sgro Letters read on TWiV 319 Weekly Science Picks Alan - The Toaster Project by Thomas ThwaitesRich - SpaceX reusable rocket (SpaceX)Kathy - Antarctica: A Year on IceDickson - NHL Mumps outbreak and Hubble Andromeda imageVincent - We the Microbiologist Listener Pick of the Week Neva - Mosquito earringsBasel - Flu vaccine selection meeting Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Host: Vincent Racaniello Guests: Marshall Bloom, Sonja Best, and Byron Caughey Vincent visits the Rocky Mountain Laboratories in Hamilton, Montana and speaks with Marshall, Sonja, and Byron about their work on tick-born flaviviruses, innate immunity, and prion diseases. Links for this episode Rocky Mountain Laboratories, NIH Flavivirus persistence (Path Dis) Flaviviruses antagonize IRF1 (J Imm) Prion test using nasal brushings (NEJM) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Matthew Daugherty, Jondavid deJong, Helen Lazear, Stefan Oliver, and Cara Pager. Vincent returns to Madison, Wisconsin and meets with postdocs to discuss their science and their careers. Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app. Links for this episode: TWiV 189: Five postdocs in Glasgow ASM at the USA Science and Engineering Festival ASV 2012 at Madison, WI Photographs of ASV 2012 TWiV on Facebook Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

The TWiV team speaks with Amit Kapoor and Ian Lipkin about how they discovered canine hepacivirus, and its implications for the origin and evolution of hepatitis C virus.

On episode #90 of the podcast This Week in Virology, Vincent, Alan, Rich and Eric discuss identification of viruses in Northeastern American bats, vaccinia virus infection after sexual contact with a military vaccinee, and identification of a new flavivirus from an Old World bat in Bangladesh. Host links Vincent Racaniello, Alan Dove, Rich Condit, and Eric F. Donaldson Links for this episode: Vaccinia virus infection after sexual contact with vaccinee Smallpox vaccination overview Smallpox vaccine lesions (jpg) Smallpox hospital, Roosevelt Island, NY (photo 1, photo 2) Isolation of a flavivirus from bats in Bangladesh (PLoS Pathogens) Review on hepatitis G virus Dickson has been teaching at Singularity University and fishing in Bozeman MT (jpg) Letters read on TWiV 90 Weekly science picks: Eric - Year of Darwin by Sean Carroll Rich - March of the Penguins Alan - Standing-height desks Vincent - DengueWatch (thanks Richard!)