Podcasts about Permeability

The blood-brain barrier (BBB)

There's an ingredient that nobody's really talking much about that's being sneaked into our food and is eroding our first line of defense against all of the chronic diseases of aging.  The most likely things to take away our resilience or kill us early are metabolic dysfunction, cardiovascular disease, cancer, neurodegenerative disease and autoimmune diseases.  We have a built-in protective defense system, but it's getting literally dissolved away by this food ingredient.  Eliminating it will help you age at an elite level so you're capable of living more as you get older, rather than less.Come hang out with meSend me a message: healthcouragecollective@gmail.comTake My Udemy Course about The Basics of Female Bioidentical Hormone Replacement Therapy: 

US EPA's Office of Research and Development (ORD) is sponsoring a presentation on electrokinetic (EK)-enhanced in situ remediation technologies that are available for addressing contaminants in low-permeability (low-k) subsurface environments where conventional hydraulic delivery technologies often face challenges. The presentation introduces ORD's recently published Engineering Issue Paper (EIP) on the technology. The primary author will present on EK technologies and provide insights to the user community on ways to best utilize the EIP. ORD's EIPs are a series of technology transfer documents that summarize the latest information on selected waste treatment and site remediation technologies and related issues and present it in a conveniently accessible manner to the user community. EIPs are designed to help remedial project managers (RPMs), on-scene coordinators (OSCs), contractors, and other contaminated sites technical staff and site managers understand the type of data and site characteristics that are needed to evaluate a technology for a specific site, as well as ways to design and optimize a technology for a particular application. To view this archive online or download the slides associated with this seminar, please visit http://www.clu-in.org/conf/tio/Low-K-Enviro_092624/

US EPA's Office of Research and Development (ORD) is sponsoring a presentation on electrokinetic (EK)-enhanced in situ remediation technologies that are available for addressing contaminants in low-permeability (low-k) subsurface environments where conventional hydraulic delivery technologies often face challenges. The presentation introduces ORD's recently published Engineering Issue Paper (EIP) on the technology. The primary author will present on EK technologies and provide insights to the user community on ways to best utilize the EIP. ORD's EIPs are a series of technology transfer documents that summarize the latest information on selected waste treatment and site remediation technologies and related issues and present it in a conveniently accessible manner to the user community. EIPs are designed to help remedial project managers (RPMs), on-scene coordinators (OSCs), contractors, and other contaminated sites technical staff and site managers understand the type of data and site characteristics that are needed to evaluate a technology for a specific site, as well as ways to design and optimize a technology for a particular application. To view this archive online or download the slides associated with this seminar, please visit http://www.clu-in.org/conf/tio/Low-K-Enviro_092624/

This is a free preview of a paid episode. To hear more, visit smokeempodcast.substack.comNancy here. One of the super-cool things about being a journalist is that you can contact people whose work amazes you and say, “Come on my podcast!” and they almost always say, “Sure!”As did Michael Powell, one of my favorite journalists working today, currently at The Atlantic and previously at The New York Times, where, during the height of our national meltdown (aka 2020 to 2022), Michael took on subjects many of his colleagues and others in media would not touch: DEI, Title IX, and using identity as a scythe to cut down those deemed not the right color or gender or whose whose views were opportunistically seen as problematic. “We lost our bearings,” says Michael, who kept true to course, and to say his clear-eyed work made me feel less crazy is an understatement.Of deep value and delight is also his 2019 book, Canyon Dreams: A Basketball Season on the Navajo Nation. I felt as though I were living inside the work as I read, and I cannot wait to see Rez Ball, the movie it inspired and which opens September 27.Also discussed:* The explosive DNC protests that weren't* COVID would cool down the culture wars, right? [Insert laugh track here]* The “scurrilous piece of journalism” in the Daily Beast by a writer Nancy now admires** The firing of veteran New York Times science reporter Donald McNeil Jr.? “Not the best moment of the New York Times, at all.” * The tenderness and importance of Jihad Rehab (now retitled The UnRedacted) and the shame of Abigail Disney* “Hey Michael, you're white…”Plus, the permeability between worlds that you start to see when hanging in the Native world, the politician Michael always thought of as “a clown,” some high-tone hot boxes, and much more!Want to become a paid subscriber? Skoden!*Max Tani, now at SemaforCross-posted at Make More Pie

In this episode, we delve into the complexities of how Borrelia burgdorferi, the bacterium responsible for Lyme disease, impacts the brain, leading to neuroinflammation and a spectrum of neurological symptoms. We'll explore the pathophysiology of Borrelia's interaction with the brain's blood-brain barrier, its evasion of the immune system, and the direct effects on neural cells. Additionally, we'll discuss specific neurological symptoms and manifestations. Topics: 1. Introduction - Overview of Lyme disease and its causative agent, Borrelia burgdorferi. - Explanation of Borrelia's invasive nature and its ability to cross biological barriers like the blood-brain barrier (BBB). 2. Understanding the Blood-Brain Barrier (BBB) - Endothelial Cells: Primary cellular component of the BBB, unique to the brain for their tightly joined structure. - Astrocytes: - Role in regulating blood flow through neurovascular coupling. - Interaction with neurons and release of vasoactive substances. - Contribution to BBB integrity by influencing tight junction formation. - Pericytes: - Contribution to BBB permeability and regulation through contractile capabilities. 3. Sponsor Break: Daily Nouri 4. Pathophysiology of Borrelia in the Brain - Invasion Mechanisms: - Borrelia's ability to adhere to and invade endothelial cells. - Role of surface proteins and induction of matrix metalloproteinases (MMPs). - Immune Evasion and CNS Invasion: - Antigenic variation to avoid immune detection. - Triggering of immune responses within the CNS, involving microglia and peripheral immune cells. - Cytokine production and its consequences on neuronal health. 5. Direct Impact on Brain Cells - Neurons: Effects of Borrelia invasion on cellular functions, mitochondrial dysfunction, and apoptosis. - Astrocytes: Transition to reactive astrocytes in the presence of Borrelia and their role in neuroinflammation. - Oligodendrocytes: Impact on myelin production and implications for cognitive and motor functions. 6. Sponsor Break: AX3 Life 7. Neurological Symptoms and Manifestations - Symptoms Overview: Headaches, facial palsy, cognitive impairments, nerve root inflammation, POTS. - Psychiatric Manifestations: Potential psychological symptoms like depression and anxiety due to neuroinflammation. 8. Conclusion - Importance of addressing neurological symptoms of Lyme through a bioindividual and root-cause approach. - Recap of key points and reference to previous relevant episodes for further listening. Thank you to our episode sponsors: Check out Daily Nouri and use code CHLOE20 for 20% off your order. Check out ⁠AX3 Astaxanthin⁠ and use discount code ⁠CHLOE20⁠ for 20% off your first order. Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Emulsifiers are common in our diets, enhancing the texture, appearance and shelf life of many foods. But are they safe? In today's episode, Jonathan and Federica uncover the surprising truth about emulsifiers in our food. We learn the science behind emulsifiers, their impact on health, and the rising concerns over there extensive use in ultra-processed foods. Dr Federica Amati is a King's College London researcher and a registered nutritionist. She is also a lecturer and Nutrition Topic Lead at Imperial College School of Medicine. Federica empowers people with accessible, practical knowledge to make informed choices on diet and lifestyle and to improve health based on unique needs and preferences, at every stage of life. Learn how your body responds to food

Biomedical Engineer Margot Damaser meets Research Scientist Petra de Graaf and Pharmacologist Pradeep Tyagi to discuss their captivating ICS abstract presentations on urethral structure disease studied using a human urethra-on-a-chip and the interaction between perfusion and permeability in bladder inflammation.Human urethra-on-a-chip to study urethral sticture diseaseProbing The Interplay of Perfusion and Permeability in Bladder Inflammation Early registration for ICS 2024 Madrid is now open at www.ics.org/2024The ICS annual meeting is the must-attend, multidisciplinary event for clinical and research scientists interested in: Urology Urogynaecology Female and functional urology Gynaecology Bowel dysfunction Neurourology Pure and applied science Physiotherapy Nursing Geriatrics The ICS 2024 Madrid conference fosters collaboration between all disciplines involved in continence care.

Dr. Penner describes two primary factors of gut health to be absorption and barrier function or permeability. His lab's work on permeability is suggesting that intestinal regions really drive total gut permeability to a much greater extent than ruminal permeability in dairy cows. (7:06)Ms. Bertens is Dr. Penner's Ph.D. student and explains some new methodologies she developed for measuring gut permeability using chromium EDTA and cobalt EDTA. It's common to use an oral dose of chromium EDTA as a marker to measure total tract permeability. Claire's work, using cannulated cows, used a ruminal dose of chromium EDTA for total tract permeability and an abomasal dose of cobalt EDTA for post-ruminal permeability. Both of these markers are indigestible, non-metabolizable and have no transcellular transport mechanisms. Claire is working to publish the new method as a complete validation study has been completed. (9:15)While this method is currently limited to using cannulated animals, Greg and Claire could envision a less sophisticated and more applied on-farm technique to assess permeability. Until then, there are still a lot of management observations that can identify potential issues with gut permeability. The appearance of feces and the presence of mucin casts can both be indicative of gut issues. Certainly dry matter intake is a major influencer on gut health, and Claire also sees potential in new technologies like rumination collars or rumination ear tags. (13:47)Are there certain time points in a dairy cow's life when she is at risk for increased gut permeability? Dr. Penner describes research suggesting if weaning is implemented too abruptly, that really increases the risk for decreased barrier function of the gut. Erratic feed intake patterns resulting from withholding feed for any reason at any age can also increase the risk of leaky gut. For example, depressed intake during the transition phase, along with anything that drives a response through an underlying systemic inflammatory response, probably creates risky situations for leaky gut. Claire is currently running a study looking at the impacts of intramammary LPS infusion on gut function. Greg envisions that learning more about gut function could create a new philosophy for treating sick animals. In the past, only antimicrobials were used to treat mastitis, but now it's common to also treat with a NSAID for pain. Perhaps in the future, we will also provide treatment to accelerate the recovery of the gut to prevent secondary disorders. (16:15)How long does an off-feed event have to last to cause an issue in the gut? It seems a fairly acute time period is all that is needed. Most studies are trying to replicate what happens on-farm, for example during mastitis, heat stress or the transition period. Greg indicates that not only will permeability be impacted, but ruminal absorptive capacity can also decline rapidly in these conditions. In Claire's LPS challenge study, cows' rectal temperatures peak around six hours after the LPS infusion and usually resolve within 12 hours. But most cows do not eat for a solid 12 hours during the challenge, and they are slow to recover feed intake over the next few days. In cows that aren't sick but experience feed restriction in experimental protocols, they tend to overeat when they are allotted the full ration and this can lead to ruminal acidosis. (21:57)Increased incidences of liver abscesses in beef-on-dairy calves are being reported in the industry. Dr. Penner speculates that perhaps these calves are not always achieving adequate passive transfer, and may not be receiving high enough levels of milk replacer to support a more robust immune system. It may be the increased beef cattle genetics in the calves are putting an added requirement on growth or muscle development that may not be met by lower levels of milk replacer or even lower colostrum feeding levels. (34:40)In closing, providing cows with a consistent environment where they can meet their needs by their own behavior such as free access to feed when hungry and to a comfortable stall when it's time to rest. Cows reward consistency with health and production. Gut health in a commercial setting is a relevant issue and it might go undiagnosed or undetected. Research into where in the gut permeability is occurring will help define strategies to modulate response. While off-feed events for individual animals might be harder to recognize in a large dairy environment, new technology may allow for earlier diagnosis. (40:43)Please subscribe and share with your industry friends to bring more people to join us around the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll get a shirt in the mail to you.

There's still a lot we don't understand about the science of leaky gut. Does it cause disease or is it a symptom? What's the best way to test for it? Which treatments actually work to repair it?  Today's guest is one of the best people to begin to answer these questions.  Dr. Camilleri is a renowned gastroenterology researcher and professor at the Mayo Clinic.  Tune in to hear about cutting-edge innovations and informed understandings around leaky gut testing and treatment.  If you have any additional questions you would like answered in the future, let me know in the comments!   Watch/Read Next… What is Leaky Gut: https://drruscio.com/what-is-leaky-gut/  Leaky Gut Suplements: https://drruscio.com/leaky-gut-supplements/  Probiotics for Stomach Issues: https://drruscio.com/probiotics-for-stomach  Learn more about Dr. Camilleri's work: https://www.mayo.edu/research/faculty/camilleri-michael-m-d-d-sc/bio-00026245    Timestamps 00:00 Intro  03:25 Dr. Camilleri's background with leaky gut 05:05 Bile-acid supplementation  07:20 The small intestine  11:07 The prevalence of leaky gut  14:25 Leaky gut & diseases 20:08 Leaky gut & inflammation 30:18 Treatment: Where to start  36:09 Biomarkers of leaky gut 48:53 Leaky gut testing  53:24 Gluten intolerance prevalence  59:52 Food elimination & reintroduction  01:04:47 Prebiotics & FODMAPs 01:15:26 Probiotics   Featured Studies  What to do about the leaky gut: https://pubmed.ncbi.nlm.nih.gov/34509978/ Leaky gut: mechanisms, measurement and clinical implications in humans: https://pubmed.ncbi.nlm.nih.gov/31076401/ Development and Validation of Test for "Leaky Gut" Small Intestinal and Colonic Permeability Using Sugars in Healthy Adults: https://pubmed.ncbi.nlm.nih.gov/33865841/  A case for improved assessment of gut permeability: a meta-analysis quantifying the lactulose:mannitol ratio in coeliac and Crohn's disease: https://pubmed.ncbi.nlm.nih.gov/35012471/  Food Emulsifiers and Metabolic Syndrome: The Role of the Gut Microbiota: https://pubmed.ncbi.nlm.nih.gov/35892789/ Food Additive Emulsifiers and Their Impact on Gut Microbiome, Permeability, and Inflammation: Mechanistic Insights in Inflammatory Bowel Disease: https://pubmed.ncbi.nlm.nih.gov/33336247/ Serum zonulin and its diagnostic performance in non-coeliac gluten sensitivity: https://pubmed.ncbi.nlm.nih.gov/32060130/ Psychological and Gastrointestinal Symptoms of Patients with Irritable Bowel Syndrome Undergoing a Low-FODMAP Diet: The Role of the Intestinal Barrier: https://pubmed.ncbi.nlm.nih.gov/34371976/  Probiotics fortify intestinal barrier function: a systematic review and meta-analysis of randomized trials: https://pubmed.ncbi.nlm.nih.gov/37168869/  Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome: https://pubmed.ncbi.nlm.nih.gov/30108163/    Get the Latest Updates Facebook - https://www.facebook.com/DrRusciodc Instagram - https://www.instagram.com/drrusciodc/ Pinterest - https://www.pinterest.com/drmichaelrusciodc    DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment. Music featured in this video: "Modern Technology" by Andrew G, https://audiojungle.net/user/andrew_g  *Full transcript available on YouTube by clicking the “Show transcript” button on the bottom right of the video.

Building upon our previous discussion on optimizing the cortisol awakening response (ep. 89) for more productive mornings, we now shift our focus to the vital role of mitochondria in enhancing our energy and productivity in the new year. We'll explore the intricate structures within mitochondria, the mechanisms leading to dysfunction, and most importantly, uncover effective strategies, including supplements and dietary choices, to optimize mitochondrial function. Topics: 1. Introduction to Mitochondrial Dysfunction and Energy Production - Overview of optimizing natural energy levels - Factors leading to mitochondrial dysfunction and FATIGUE 2. Understanding Mitochondrial Structures - Outer membrane - Permeability and function - Intermembrane space - Role in proton gradient - Inner membrane - Cristae and its significance - Matrix - Krebs cycle and NADH generation - Mitochondrial DNA and ribosomes 3. Mechanisms of Mitochondrial Dysfunction - Loss of inner mitochondrial membrane potential - Alterations in the electron transport chain - Reduced transport of critical metabolites 4. Ways to Improve Mitochondrial Function - Preface for non-root cause issues - Factors causing mitochondrial damage - Example of ROS impact on ATP production 5. Supplements for Enhancing Mitochondrial Function - Alpha lipoic acid - Role in increasing glutathione levels - L-carnitine - Fatty acid transport and mitochondrial function - Use in weight loss - CoQ10 - Involvement in the electron transport chain - Mitochondrial membrane phospholipids - Lipid replacement therapy for repairing damage already done 6. Essential Minerals and Micronutrient Blood Panel - Importance of essential minerals in mitochondrial metabolism - The need for micronutrient blood panel 7. NAD+ and NADH - Importance in the electron transport chain - Precursors like NMN and NR for optimization 8. Other Modalities for Mitochondrial Support - Mention of red light therapy - Emphasis on dietary choices and antioxidant intake - Importance of structural repair with lipid replacement therapy 9. Additional Tools and Research - Urolithin A for stimulating mitochondrial recycling process Thanks for tuning in! ⁠⁠⁠⁠⁠Book An Intro Coaching Call with Chloe Porter⁠⁠⁠⁠⁠ Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok ⁠⁠⁠⁠⁠@chloe_c_porter⁠⁠⁠⁠⁠ Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

It's a wrap! The Spotify variety, if you know what I mean... This year I thought it would be fun to do a live "unwrapping" of the Podcasters Wrapped, which provides fun information and insights about your podcast (those that use Spotify are oh so familiar with this fun annual event!). I found it amazing and hysterical that The Red Light Report community has nearly identical tastes to me, both in regards to  top podcast genres listened to and top music genres listened to. I have no doubt we could all get along!   On a more mitochondrial note, I found a highly interesting research article on methylene blue and its potential as an anti-aging drug. To a large degree, this should come as no surprise given methylene blue's immense and dynamic impact on the mitochondria and, as we all know, the inherent tie our mitochondria's health and function has on our overall welling and lifespan. The review discusses the anti-aging effects of MB with a focus on the relationship between mitochondrial dysfunction and aging.The article did a fantastic job of verifying this by looking at the profound role "the blue" can play on the aging brain, particularly those neurodegenerative conditions we associate with our latter years -- Alzheimer's disease and Parkinson's disease. From the article: "​Since MB is an FDA-approved medicine with a long history, the safety of MB usage has been thoroughly evaluated. The exploration of MB utilization in aging-related conditions can help us understand the aging process. Derivatives of MB can also be developed to improve its effects."Could methylene blue be one of the most effective (while still being incredibly safe) anti-aging drugs ​known to mankind? The jury is out, but the current data is quite strong. Let's not forget it's remarkable synergism with red light therapy...​​ As always, light up your health! - Key points Introduction, Holiday Greetings, and Spotify 2023 Wrapped (00:00:00 - 00:16:41) Additional Avenues for Red Light Therapy, Mitochondrial Health, and Methylene Blue (00:16:41 - 00:17:08) Article Introduction on Methylene Blue as an Anti-Aging Drug (00:17:09 - 00:17:34) Free Radicals Theory of Aging and Mitochondrial Health (00:17:35 - 00:23:36): 00:20:35 - 00:26:36 Methylene Blue as an Anti-Aging Drug (00:23:37 - 00:24:39): 00:26:37 - 00:27:39 Synergistic Effects of Red Light Therapy and Methylene Blue (00:24:40 - 00:25:39): 00:27:40 - 00:28:39 Methylene Blue's Permeability, Historical Uses, and Applications (00:25:39 - 00:26:49): 00:28:39 - 00:29:49 French Study on Methylene Blue and Potential Antiviral Effects (00:26:49 - 00:28:03): 00:29:49 - 00:31:03 Dosages, Safety, and Benefits of Methylene Blue (00:28:03 - 00:29:58): 00:31:03 - 00:32:58 Recommendations and Personal Example (00:29:58 - 00:32:35): 00:32:58 - 00:35:35 Ongoing Benefits, Comparisons to Red Light Therapy (00:32:35 - 00:33:54): 00:35:35 - 00:36:54 Applications Section - Methylene Blue in Brain Aging (00:33:54 - 00:35:09): 00:36:54 - 00:38:09 Methylene Blue's Impact on Mitochondrial Function and Brain Diseases (00:35:09 - 00:37:43): 00:38:09 - 00:40:43 Role in Alzheimer's and Parkinson's Diseases (00:37:44 - 00:41:23): 00:40:44 - 00:44:23 Memory Enhancement and Benefits in Treating Brain Aging (00:41:23 - 00:43:12): 00:44:23 - 00:46:12 Summarizes Importance of Methylene Blue in Mitochondrial Health (00:43:46 - 00:46:47): 00:46:46 - 00:49:47 Potential Derivatives, Broader Implications (00:46:47 - 00:47:36): 00:49:47 - 00:50:36 Pervasive Role of Mitochondria, Simple Health Improvement Strategies (00:47:36 - 00:49:24): 00:50:36 - 00:52:24 Encouragement for Ratings and Reviews (00:49:44 - 00:49:48): 00:52:44 - 00:52:48 Conclusion - Wishing Listeners an Amazing Week and Prioritizing Health (00:49:48 - End) - Learn more about methylene blue & BioBlue: Methylene blue​ ​BioBlue - Dr. Mike's #1 recommendations: Grounding products: Earthing.com EMF-mitigating products: Somavedic Blue light blocking glasses: Ra Optics - To learn more about red light therapy, methylene blue, and shop for the highest-quality red light therapy products, visit https://www.biolight.shop - Stay up-to-date on social media: Dr. Mike Belkowski: Instagram LinkedIn   BioLight: Instagram YouTube Facebook

Timestamps & Summary Dr. Greg Eckerle (01:24)Do we normally call that intestinal acidosis outside of the agricultural university complex?Dr. Greg PennerI think probably the most common term that's used is hindgut acidosis rather than intestinal acidosis. And it probably makes sense given where we think most of that fermentation activity would occur and where the primary reduction in PH would be localized.Dr. Greg Eckerle (02:02)What can we do with the hindgut intestinal acidosis? And how is that having an impact?Dr. Greg PennerFirst of all, one of the things we need to recognize is rumen acidosis and hindgut acidosis often occur simultaneously. And in fact, we probably should reclassify ruminal acidosis to lumenal, so that it encompasses a broader area of the gastrointestinal tract. You're right, from a challenge or mitigating response, it's not easy to deliver compounds that are going to be released to buffer in the large intestine. So, we're really needing to focus more on strategies that promote ruminal digestion efficiently while minimizing or managing the risk of fermentable materials that reach the large intestine.Dr. Greg Eckerle (05:19)Is there any sort of mitigation practices that we could utilize to help keep that intestinal junction and intestinal villi healthy?Dr. Greg PennerCertainly, our data as well as others have shown that if PH is too low for too long, again, we don't have good thresholds characterized for the hindgut, but we do see a leaky gut, or at least increased permeability of the gut. Our work has been able to show that both outside of the animal using ex vivo conditions and also inside the animal using in vivo markers, we actually see greater permeability responses in post-ruminal regions rather than the ruminal region. […]Dr. Greg Eckerle (08:27)What can we utilize and look at when we see animals undergoing a medicinal acid challenge?Dr. Greg PennerI think it's really hard to differentiate ruminal acidosis and hindgut acidosis. And as I mentioned earlier, they often occur simultaneously. I think in many cases, we've looked at indicators of hindgut acidosis as evidence for ruminal acidosis. And so we've probably been looking at it backward. […]Dr. Greg Eckerle (11:56)Do we see an alteration in more pathogenic bacteria or harmful bacteria to the animal which could lead to increased ailments, transition of other things that enterotoxins, and things like that?Dr. Greg PennerThere was some nice work done by Dr. Kees Plaizier at the University of Manitoba where they did some grain versus alfalfa induction protocols for ruminal acidosis. And fortunately, they have both ruminal microbial changes. And in some of those studies, they also have hindgut microbial changes. And if I recall right, I believe E. Coli abundance, I think they stopped at a genre level, but E. Coli abundance was increased. And so certainly we get concerned about E. Coli from a potential contaminant of meat or meat products and not something we want to increase concentration of, recognizing not all E. Coli will be harmful or truly pathogenic. […]Dr. Greg Eckerle (13:48)When we look at the terminal carcass evaluation of these animals, do we see an increase in liver abscess scores from Fusobacterium that may cross this damaged intestinal?Dr. Greg PennerThat's a great question, and that's the hypothesis we have. But unfortunately, I have not seen any data that confirms whether fusobacterium is crossing the rumen, crossing regions of the intestine, or both. […]Dr. Greg Eckerle (16:15)Are there certain production periods for either both beef and dairy that we need to be paying more attention to with those management practices to help reduce those risks?Dr. Greg PennerLet's start on the dairy side. I think probably the greatest risk factor is early in the transition phase. And the reason I say that is there's a number of changes that have likely occurred during that time. […]In terms of feedlot cattle, I think any factor, again, that leads to a reduction in feed intake, even a transient reduction, probably increases risk for rumen and hindgut acidosis. So, these could be things like respiratory disease, it could be heat stress events, they could be transportation events. […]Dr. Greg Eckerle (21:52)What would be three of the main take-home messages that we have for nutritionists, veterinarians, and producers when we want to help mitigate or strategize systems on farms?Dr. Greg PennerI think the first one is […] that what happens in the rumen influences the more distal parts of the gastrointestinal tract. […]The second one is when we look at the responsiveness of the intestinal regions, they're probably regions that are more prone to leakiness. […]The third one goes back to good standard practices, and I think this will never be eliminated from core tasks or core skills of a nutritionist bunk calling. […]

Leaky gut, LPS, and exciting research about your microbiome and how to heal your gut – and thereby your entire body. Leaky gut is the number one driving factor behind morbidity and mortality worldwide. But this interview delivers information on how to heal. Research shows that you can reduce leaky gut and its inflammatory effects by 70-90% in just 30 days. Listen to how in this episode.Kiran is an internationally well-known research … läs mer Inlägget 341b: Kiran Krishnan – Leaky gut. Get healthy by healing gut permeability (English) publicerades först på 4Health.se by Anna Sparre. Inlägget 341b: Kiran Krishnan – Leaky gut. Get healthy by healing gut permeability (English) dök först upp på 4Health.se by Anna Sparre.

Today's episode dives into a not-so-well-known oral peptide supplement, formerly called AT-1001, and now referred to as larazotide acetate. We go over what this peptide does within the gut, how it blocks zonulin receptors, where to get it, why it's not well-known, and so much more! Truly, the research is pretty incredible and intriguing, so stay tuned... because this peptide could very well be the next game-changing supplement for "leaky gut!" Topics: 1. Discussion on Anti-Zonulin Peptide Compound - Introduction to the topic 2. The Gut Lining's Structure and Composition - Villi and Microvilli: Enhancing Surface Area - The presence and importance of crypts - Monolayer of epithelial cells explained 3. Different Types of Cells in the Gut Lining - Enterocytes: Absorption of Nutrients - Goblet Cells: Mucus Secretion - Paneth Cells: Antibacterial Function - M Cells: Immune Surveillance - Enteroendocrine Cells: Hormone Secretion - Stem Cells: Renewal and Replenishment 4. Tight Junctions: Ensuring Gut Integrity - Definition and importance of tight junctions - Components of tight junctions: Claudins, Occludin, JAMs - Interaction with the cytoskeleton through ZO proteins - Dynamic regulation in response to various conditions 5. Zonulin's Role in Intestinal Permeability - Gliadin's interaction with enterocytes leading to zonulin release - Zonulin's impact on the cytoskeleton and, therefore, tight junctions - Gliadin peptides' interaction with immune cells and celiac disease 6. Other Factors Influencing Zonulin Release and Gut Integrity - List of factors that directly or indirectly affect gut integrity 7. Larazotide Acetate: A Novel Peptide Compound - Definition and mechanism of action - Real-world implications and studies 8. Current State and Future of Larazotide Acetate - Studies and their discontinuation? - Its emergence in peptide supplement companies - The importance of consulting with medical professionals Thanks so much for tuning in! Order Chloe's Book "⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠" TODAY! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.28.551049v1?rss=1 Authors: Keshavanarayana, P., Spill, F. Abstract: The inner lining of blood vessels, the endothelium, is made up of endothelial cells. Vascular endothelial (VE)-cadherin protein forms a bond with VE-cadherin from neighbouring cells (homophilic bond) to determine the size of gaps between the cells and thereby regulate the size of particles that can cross the endothelium. Chemical cues such as Thrombin, along with mechanical properties of the cell and extracellular matrix (ECM) are known to affect the permeability of endothelial cells. Abnormal permeability is found in patients suffering from diseases including cardiovascular diseases, cancer, and COVID-19. Even though some of the regulatory mechanisms affecting endothelial permeability are well studied, details of how several mechanical and chemical stimuli acting simultaneously affect endothelial permeability are not yet understood. In this article, we present a continuum-level mechanical modelling framework to study the highly dynamic nature of the VE-cadherin bonds. Taking inspiration from the catch-slip behaviour that VE-cadherin complexes are known to exhibit, we model VE-cadherin homophilic bond as cohesive contact with damage following a traction-separation law. We explicitly model the actin-cytoskeleton, and substrate to study their role in permeability. Our studies show that mechano-chemical coupling is necessary to simulate the influence of the mechanical properties of the substrate on permeability. Simulations show that shear between cells is responsible for the variation in permeability between bicellular and tri-cellular junctions, explaining the phenotypic differences observed in experiments. An increase in the magnitude of traction force that endothelial cells experience results in increased permeability, and it is found that the effect is higher on stiffer ECM. Finally, we show that the cylindrical monolayer exhibits higher permeability than the planar monolayer under unconstrained cases. Thus, we present a contact mechanics-based mechano-chemical model to investigate the variation in permeability of endothelial monolayer due to multiple loads acting simultaneously. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Rob and Ryan watched and break down Season 2, Episode 14 of the Big Bang Theory: The Financial Permeability!**GIVE US A 5 STAR REVIEW ON APPLE PODCASTS AND BE ENTERED IN TO WIN A $100 GIFT CARD TO AMAZON! BETTER LISTEN TO THE EPISODE FOR DETAILS! https://podcasts.apple.com/us/podcast/theoretical-nonsense-the-big-bang-theory-watch-a/id162307941400:00:00 - Intro, emails, neighbor update00:11:21 - Recap Begins00:20:00 - Snack Wars! Twizzlers vs Redvines & Icees vs Slurpies 00:31:18 - What are the most popular movie theater snacks, ranked!  00:46:56 - What's an epaulet? and what's the deal with berets? 01:03:15 - Finding the endurance to succeed01:13:26 - What's makes someone a professional?01:16:33 - What is the penalty for public urination in CaliforniaFind us everywhere at: https://linktr.ee/theoreticalnonsense~~*CLICK THE LINK TO SEE OUR IQ POINT HISTORY TOO! *~~-------------------------------------------------Welcome to Theoretical Nonsense! If you're looking for a Big Bang Theory rewatch podcast blended with How Stuff Works, this is the podcast for you!  Hang out with Rob and Ryan where they watch each episode of The Big Bang Theory and break it down scene by scene, and fact by fact, and no spoilers! Ever wonder if the random information Sheldon says is true? We do the research and find out! Is curry a natural laxative, what's the story behind going postal, are fish night lights real? Watch the show with us every other week and join in on the discussion! Email us at theoreticalnonsensepod@gmail.com and we'll read your letter to us on the show! Even if it's bad! :) If you need any artwork done for you, check out johnkimdesigns.comMusic by Alex Grohl. Find official podcast on Apple, Stitcher, and Spotify https://podcasts.apple.com/us/podcast/theoretical-nonsense-the-big-bang-theory-watch-a/id1623079414

Struggling with Celiac Disease, leaky gut, food sensitivities or bodywide complaints that you think may originate in your gut? Explore strategies to individualize your diet to attain a healthy and diverse gut microbiome. Also, learn about critical food preparation steps for legumes to minimize gut damage with Vincent Pedre, MD. Lindsey Parsons, your host, helps clients solve gut issues and reverse autoimmune disease naturally. Take her quiz to see which stool or functional medicine test will help you find out what's wrong. She's a Certified Health Coach at High Desert Health in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on Facebook, Tiktok, Twitter, Instagram or Pinterest or reach her via email at lindsey@highdeserthealthcoaching.com to set up a free 30-minute Gut Healing Breakthrough Session. Show Notes

This episode is brought to you by Cozy Earth, BiOptimizers Magnesium Breakthrough, and Levels. Today on The Dhru Purohit Podcast, Dhru sits down with Dr. Akil Palanisamy to discuss why there's been such an explosion in autoimmune disease and how certain insults in our modern-day society—like heavy metals, pesticides, poor diet, and chronic stress—could be to blame. Dr. Akil is a renowned Integrative Medicine practitioner who combines conventional medicine with holistic approaches like Functional Medicine and Ayurveda. He is a Harvard graduate and received his MD from the University of California, San Francisco. Dr. Akil completed his residency training at Stanford University and a fellowship in Integrative Medicine with Dr. Andrew Weil at the University of Arizona. He has authored two books, The Paleovedic Diet and The TIGER Protocol which is set to be released on May 9th. In this episode, Dhru and Dr. Akil dive into:-The recent explosion in autoimmune disease (2:26)-Top toxins that contribute to autoimmunity (6:26)-How to combat toxin exposure using lifestyle (22:12)-Conventional treatments for autoimmune disease (34:08)-Why autoimmune conditions develop (39:23)-Case example of people at high risk for autoimmunity (1:11:00)-Dr. Akil's two-phase diet recommendations for autoimmune disease (1:21:30)-Blood tests and symptoms to detect early stages of autoimmunity (1:32:33)-Foods central to repairing the gut (1:37:22)-The carnivore diet for autoimmunity explained (1:48:36)-Ancient Ayurvedic principles we can apply to our modern lifestyle (2:01:33)-The importance of rest and mindset in autoimmunity (2:13:46)Also mentioned in this episode:-Dr. Akil's clinic, Sutter Health-The Paleovedic Diet-Preorder Dr. Akil's new book, The TIGER Protocol here. For more on Dr. Akil Palanisamy, check out his website, doctorakil.com. Cozy Earth are the most comfortable, temperature-regulating, and nontoxic sheets on the market. Right now, get 40% off your Cozy Earth sheets. Just head over to cozyearth.com and use code DHRU.Right now, you can get 10% off Sleep Breakthrough. And if you buy two or more you'll get a free bottle of Magnesium Breakthrough. This is a limited-time offer! So just go to sleepbreakthrough.com/dhru and use code dhru10.By leveraging biosensors like continuous glucose monitors (CGMs), Levels provides real-time feedback on how diet and lifestyle choices impact your metabolic health. Right now, Levels is offering my listeners two free months of their Levels Membership. Head on over to levels.link/DHRU to learn more. Hosted on Acast. See acast.com/privacy for more information.

Blog summary of an Editorial was published in Oncotarget, entitled, “Permeability and driving force: why is it difficult to control glycolytic flux by blocking lactate transporters?“ _________________________________ The process of glycolysis, or the conversion of glucose to energy in cells, is a critical component of many biological processes. This process is highly regulated, and glycolytic flux has been implicated in a variety of disease states, including cancer and diabetes. Despite significant advances in our understanding of glycolysis, researchers continue to find it difficult to control glycolytic flux. “Overall, glycolysis facilitates tumour proliferation and survival, and has become a hotly-pursued target for therapeutic inhibition.” In a new editorial paper, researchers Wiktoria Blaszczak and Pawel Swietach from the University of Oxford explored the challenges of this issue and potential solutions. On January 26, 2023, their editorial was published in Oncotarget and entitled, “Permeability and driving force: why is it difficult to control glycolytic flux by blocking lactate transporters?“ “In our recent study (Blaszczak et al. (2022)), using a panel of pancreatic ductal adenocarcinoma cell lines, we characterised how extracellular acidity feeds back to inhibit further glycolytic acid production [6].” Full blog - https://www.oncotarget.org/2023/02/16/controlling-glycolytic-flux-therapy-challenges-and-solutions/ DOI - https://doi.org/10.18632/oncotarget.28351 (PDF Download) Correspondence to - Wiktoria Blaszczak - wiktoria.blaszczak@dpag.ox.ac.uk Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28351 Keywords - MCT inhibitors, fermentative metabolism, lactate, PDAC, SLC16A1 About Oncotarget Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form, and then quickly released to Pubmed. On September 15, 2022, Oncotarget was accepted again for indexing by MEDLINE. Oncotarget is now indexed by Medline/PubMed and PMC/PubMed. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/OncotargetYouTube LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

In this podcast Kate Allen and Laura Fitzharris are talking about 'Training the equine respiratory muscles: Inspiratory muscle strength' and Wendy Pearson discusses 'The combination of trailer transport and exercise increases gastrointestinal permeability and markers of systemic inflammation in horses'.

The symptoms of ADHD can be exacerbated by inflammatory foods such as gluten, dairy and soy. Learn from Dana Kay, Board-Certified Holistic Health and Nutrition Practitioner, about the effects inflammatory foods have on ADHD and what supplements can help reduce the symptoms of ADHD. Lindsey Parsons, your host, helps clients solve gut issues and reverse autoimmune disease naturally. Take her quiz to see which stool or functional medicine test will help you find out what's wrong. She's a Certified Health Coach at High Desert Health in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on Facebook, Twitter, Instagram or Pinterest or reach her via email at lindsey@highdeserthealthcoaching.com to set up a free 30-minute Gut Healing Breakthrough Session. Show Notes

*Plasma vs Dark Matter: While old earth secular scientists continue to search for “dark matter” to rescue their failing Big Bang cosmology, friend of RSR Joe Spears joins Fred and his co-host Doug McBurney to look further into the Setterfield Plasma Cosmology. *Godspeed: Fred and Joe discuss why light may have traveled faster in the past, and why it may very well be slowing down. Also see Fred & Doug's previous show back in March 2022 on how the fix is in for speed of light measurements. *Quantized Red Shift Explained: Hear how the observed data regarding the red shift reveals the likelihood of an electromagnetic creation week more so than a gravitational 13.549567 Bn Years. Plasma cosmology also removes the need to explain red shifts via an expanding universe, which is a better fit for scripture given that God said He "stretched the heavens", past tense! *Permittivity and Permeability: Einstein described the speed of light in a vacuum as a constant. But Fred Williams has observed the slowing of the speed of light personally! We know that light travels more slowly through a medium. Hear how the “fabric” of the universe may impact the speed of light. *The Big Stretch: Thus says God the LORD, Who created the heavens and stretched them out, Who spread forth the earth and that which comes from it, Who gives breath to the people on it, And spirit to those who walk on it: “I, the LORD, have called You in righteousness, And will hold Your hand; - Is 42: 5-6. Hear what this stretching may have involved, preserving the conservation of energy, while allowing distant starlight visible from the earth in less than 10,000 years.

*Plasma vs Dark Matter: While old earth secular scientists continue to search for “dark matter” to rescue their failing Big Bang cosmology, friend of RSR Joe Spears joins Fred and his co-host Doug McBurney to look further into the Setterfield Plasma Cosmology. *Godspeed: Fred and Joe discuss why light may have traveled faster in the past, and why it may very well be slowing down. Also see Fred & Doug's previous show back in March 2022 on how the fix is in for speed of light measurements. *Quantized Red Shift Explained: Hear how the observed data regarding the red shift reveals the likelihood of an electromagnetic creation week more so than a gravitational 13.549567 Bn Years. Plasma cosmology also removes the need to explain red shifts via an expanding universe, which is a better fit for scripture given that God said He "stretched the heavens", past tense! *Permittivity and Permeability: Einstein described the speed of light in a vacuum as a constant. But Fred Williams has observed the slowing of the speed of light personally! We know that light travels more slowly through a medium. Hear how the “fabric” of the universe may impact the speed of light. *The Big Stretch: Thus says God the LORD, Who created the heavens and stretched them out, Who spread forth the earth and that which comes from it, Who gives breath to the people on it, And spirit to those who walk on it: “I, the LORD, have called You in righteousness, And will hold Your hand; - Is 42: 5-6. Hear what this stretching may have involved, preserving the conservation of energy, while allowing distant starlight visible from the earth in less than 10,000 years.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.31.514557v1?rss=1 Authors: Grinstein, S., Hirata, Y., Steinberg, B. E., Volchuk, A., matsuzawa, a., Cai, R., Freeman, S. A. Abstract: The ongoing metabolic and microbicidal pathways that support and protect cellular life generate potentially damaging reactive oxygen species (ROS). To counteract damage, cells express peroxidases, antioxidant enzymes that catalyze the reduction of oxidized biomolecules. Glutathione peroxidase 4 (GPX4) is the major hydroperoxidase specifically responsible for reducing lipid peroxides; this homeostatic mechanism is essential and its inhibition causes a unique type of lytic cell death, ferroptosis. The mechanism(s) that lead to cell lysis in ferroptosis, however, are unclear. We report that the lipid peroxides formed during ferroptosis accumulate preferentially at the plasma membrane. Oxidation of surface membrane lipids increased tension on the plasma membrane and led to the activation of Piezo1 and TRP channels. Oxidized membranes thus became permeable to cations, ultimately leading to gain of cellular Na+ and Ca2+ concomitant with loss of K+. These effects were reduced by deletion of Piezo1 and completely inhibited by blocking cation channel conductance with ruthenium red or 2-aminoethoxydiphenyl borate (2-APB). We also found that the oxidation of lipids depressed the activity of the Na+/K+-ATPase, exacerbating the dissipation of monovalent cation gradients. Preventing the changes in cation content attenuated ferroptosis. Together, our study establishes that increased membrane permeability to cations is a critical step in the execution of ferroptosis and identifies Piezo1, TRP channels and the Na+/K+-ATPase as targets/effectors of this type of cell death. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.13.512023v1?rss=1 Authors: Davis, G. M., Juere, E., Hayes, J. M., Davey, G. P. Abstract: Mitochondrial electron transport chain (ETC) complexes are key mediators of energy metabolism in astrocytes and neurons, with subsequent effects on memory, behaviour and neurodegeneration. Mitochondrial dysfunction and increased blood brain barrier (BBB) permeability are known pathologies in Parkinsons and Alzheimers diseases. However, knowledge of how ETC activities regulate metabolic flux and influence permeability in the BBB is lacking. Using metabolic flux control analysis we show that complex I is a critical control point for oxidative flux and permeability in brain microvascular endothelial cells derived from human induced pluripotent stem cells. Inhibition of complex I activity immediately reduced the transendothelial electrical resistance (TEER) by 60%, leading to an increase in protein transport across the BBB. These events were accompanied by a transient reduction in ATP that was recovered, along with TEER values, over an extended time period. Furthermore, while inhibition of downstream complexes III or IV decreased oxygen respiration rates, no effects on BBB permeability were identified, due to compensatory glycolytic flux and maintenance of ATP synthesis. These data show that mitochondrial complex I is critical for maintaining energy production in endothelial cells and transiently controls BBB permeability, which may contribute to brain disorders where complex I dysfunction is a hallmark. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Dr. Linda Chu discusses COVID vaccine-associated myocarditis with Dr. Kate Hanneman. "Myocardial Injury Pattern at MRI in COVID-19 Vaccine-associated Myocarditis". Myocardial Injury Pattern at MRI in COVID-19 Vaccine–associated Myocarditis. Fronza et al. Radiology 2022; 304:553–562. Dr. Nikita Consul's Radiology In Training article summary "Choroid Plexus Volume and Permeability at Brain MRI within the Alzheimer Disease Clinical Spectrum". Choroid Plexus Volume and Permeability at Brain MRI within the Alzheimer Disease Clinical Spectrum. Choi et al. Radiology 2022; 304:635–645. 

Join Fazale “Fuz” Rana and Jeff Zweerink as they discuss new discoveries taking place at the frontiers of science that have theological and philosophical implications, as well as new discoveries that point to the reality of God's existence. Cell membranes are incredibly complex biochemical suprasystems composed of hundreds of different types of lipids. Is there any rhyme or reason to the compositional makeup of cell membranes or do they merely reflect the outworking of historically contingent evolution? In this episode, Fuz Rana discusses a recent study that reveals the rationale for the compositional complexity of cell membranes, highlighting that these systems display an organization and compositional fine-tuning that can be marshaled to make a case for intelligent design. The standard model of particle physics stands as an incredibly robust model of the universe with great explanatory power. Yet scientists know it is incomplete. New measurements of the W boson mass might provide clues about how to extend the standard model. Will the new measurements hold up under further scrutiny? Will they provide ways to explain dark matter and other holes in the standard model? In this episode Fuz and Jeff discuss these important topics. References: “Membrane Thickness, Lipid Phase and Sterol Type Are Determining Factors in the Permeability of Membranes to Small Solutes,” https://doi.org/10.1038/s41467-022-29272-x Jacopo Frallicciardi, et al. (article)  “High-Precision Measurement of the W Boson Mass with the CDF II Detector,” https://www.science.org/doi/10.1126/science.abk1781 CDF Collaboration, T Aaltonen, et al. (article) Additional Resources: “Bringing Order to the Case for Intelligent Design, Part 1,” https://reasons.org/explore/publications/articles/bringing-order-to-the-case-for-intelligent-design-part-1, Fazale Rana (blog) “Biotic Borders: Cell Membranes under Scrutiny,” https://reasons.org/explore/publications/facts-for-faith/biotic-borders-cell-membranes-under-scrutiny, Fazale Rana (blog)

this sunday read-aloud is a child of the second episode of the journal of small work*, pattern language + permeability. it is concerned particularly with our permeable selves, and our bigger selves, the one that encompasses a whole earth system in perpetual exchange. this tiny piece touches on the exchanging of the possibly toxic for the definitely edible, accepting our microbial-ness, looking to the cycling of this living being we are living within for patterns that lead us to better decisions. all of that. it would be lovely to hear what you think of it. and if you missed a link i posted yesterday to a new interview with sophie from big things little things, you might like to listen in about just these sorts of concerns and approaches.with thanks to the appleturnover radio and film patrons. you make this possible. i like to think of it as a csa, like my regenerative-agrarian friends cultivate; community supported activism. thank you. follow appleturnover on patreon for more. Hosted on Acast. See acast.com/privacy for more information.

Have you heard of leaky gut? Do you know what it means to have leaky gut? Is it something that applies to you? What is it that leaks from the gut? Why would your gut become leaky, and why would it matter? Is there anything you can do about it? How many people in the western world are affected by increased intestinal permeability?Autoimmune study: https://www.ahajournals.org/doi/abs/10.1161/circ.137.suppl_1.p238Links to supplements mentioned (not affiliate links!)Ion (formerly called restore): https://zachbushmd.com/ion/Leptin Shield:https://gundrymd.com/supplements/lectin-shield/GI Integrity:https://www.pureencapsulationspro.com/g-i-integrity.htmlGI Fortify:https://www.pureencapsulationspro.com/g-i-fortify.htmlFree resources:Free Virtue Meditation: healthcourage.ck.page/meditation Guide to be ready before you get sick: https://healthcourage.ck.pageMP3 Audio of empowering questions to reprogram your subconscious: https://healthcourage.ck.page/questions

With Mud Talks 15-3 we continue a special eight-part miniseries dedicated to the topic of preserving earthen architecture. In this third episode of the series we speak to Pat Taylor, Historic Preservation Specialist & General Contractor followed by Eric Liefeld, President of Mesilla Valley Preservation, Inc. We speak about capillary action, permeability and salt attack – including sources, processes and effects of deterioration.Resources & Further Reading:Adobe Conservation - A Preservation Handbook pp. 51 to 56by Cornerstones Community Partnerships (Author), Francisco Uviña Contreras (Illustrator)Publisher: Sunstone Press (August 15, 2006)ISBN-13: 978-0865345270https://www.cstones.org/booksPozzolans for Lime Mortarsby Pat Gibbonshttps://www.buildingconservation.com/articles/pozzo/lime-pozzolans.htmHot Mixed Lime & Traditional Mortars: A Practical Guide to Their Use in Conservation and Repairby Nigel Copsey (Autor) Publisher: The Crowood Press Ltd (July 1, 2019)ISBN-13: 978-1785005558Mesilla Valley Preservation, Inc. Websitehttp://mvpres.orgSalts of the Earth: When Salts Attack!https://youtu.be/ntPbiZOnpGgThe Mud Talks Preserving Earthen Architecture series is brought to you in collaboration with Cornerstones Community Partnerships and is made possible by the support of the US Department of the Interior, National Park Service and a National Center for Preservation Technology & Training grant.

"There once was a brave lad named Leonard. With a fi-fi fiddle dee-dee. He faced a fearsome giant. While Raj just wanted to pee."Our episode discussion includes Red Vines vs Twizzlers, the relatability of both the cold open and Penny's financial issues, how society judges people who are poor, viewing scenes through our Leonard/Penny goggles, and more!Download hereRunning time: 1:04:40, 44.5 MB

Permeability is an important measure of the exchange function of microvessels, but until now, there has been a lack of physiologically-relevant in vitro microvessel models that allow an easy assessment of permeability properties of the microvessel wall. In our latest episode, Associate Editor Amanda LeBlanc (University of Louisville) interviews lead author Ping He (Penn State University) and expert Robert Hester (University of Mississippi Medical Center) about the latest research study by Gao et al., published in the AJP-Heart and Circ Call for Papers on Deconstructing Organs: Single-Cell Analyses, Decellularized Organs, Organoids, and Organ-on-a-Chip Models. Dr. He and colleagues developed a novel microvessel-on-a-chip model which allows endothelial cells to grow under continuous flow, simulating the in vivo environment, while also allowing for the assessment barrier function of the microvessel wall. The in vitro microvessel model Gao et al. developed features layers of glycocalyx and endothelium, and as Dr. He points out, endothelial junctions and glycocalyx are key components contributing to microvessel barrier function and acute inflammatory responses observed in in vivo models. Listen as we discuss the future directions of this model in both acute and chronic conditions, disease states and future molecular studies.   Feng Gao, Haoyu Sun, Xiang Li, Pingnian He Leveraging avidin/biotin interaction to quantify permeability of microvessels-on-a-chip  Am J Physiol Heart Circ Physiol, published December 13, 2021. DOI: 10.1152/ajpheart.00478.2021

If you've ever wondered whether or not bread is healthy, you've come to the right place. Bread comes in so many shapes and sizes, and ever since the whole keto diet trend came about, it's been touted as one of the worst foods out there. But is that true? In this episode, I'll break down: - whether or not bread is actually bad for you - the ins and outs of celiac disease - what it means to be non-celiac gluten sensitive - if whole grain bread is really better for you than white - how to beat the food guilt when it comes to bread ... and more! Show Notes: Otto's Cassava Flour - my favorite GF flour for making your own bread at home! Spectrum of gluten-related disorders: consensus on new nomenclature and classification Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease Effect of Gliadin on Permeability of Intestinal Biopsy Explants from Celiac Disease Patients and Patients with Non-Celiac Gluten Sensitivity Phytic Acid: From Antinutritional to Multiple Protection Factor of Organic Systems Whole Grains, Dietary Fibers and the Human Gut Microbiota: A Systematic Review of Existing Literature Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: systematic review and dose-response meta-analysis of prospective studies You can learn more about me by following on IG @imperfectlypaigewellness or by checking out my blog, freebies, and offers on my website: https://imperfectlypaigewellness.com Please share with #PaigeTalksWellness to help get the word out about the show - and join the Imperfect Health Fam over on Facebook.

So delighted to welcome back my colleague Lucy Mailing, PhD ; who was with us earlier to talk about the Gut-Skin-Axis . I am a big fan of Dr. Mailing and her deep understanding of the gut microbiome, gut immune system, and all things digestive health.  I have been a supporter of her Patreon page for several years and always learn from her unique insight. In this episode we go into all things Intestinal Barrier, Intestinal immune System, Disruptors of the intestinal lining, and more. See below for the show outline 00:00 Opening  1:49 Dr. Mailing's healing journey 11:22 Mucosal Membrane Overview 19:21 Intestinal Immune Team 23:29 Immune tolerance and loss of tolerance 27:46 Food Allergy and Sensitivity 31:56 Intestinal Barrier Disruptors 42:42 Intestinal Barrier Protectors 48:03 Intestinal Gases and Barrier effect 50:55 Where to start when addressing the intestinal barrier 55:06 Healthy Digestive Habits 1:00:02 Dr. Mailing's practice and parting words I hope you enjoy this episode as much as I did. Please click like and subscribe in your players to show your support. More about Dr. Mailing Below Lucy Mailing /PhD completed her PhD in Nutritional Sciences and continues to perform research on how diet and exercise impact the gut microbiome in states of health and disease. She has authored several peer-reviewed journal articles related to the microbiome and health and was recently named an Emerging Leader in Nutritional Sciences by the American Society for Nutrition. Lucy has also been as staff research associate for Kresser Institute for four years and writes about evidence-based gut health on her blog, www.lucymailing.com where she holds classes, writes, and provides functional medicine consulting. --- Send in a voice message: https://anchor.fm/adam-rinde/message

Over-worked or over-entertained? Our humanity gives us the joint gifts of both activity and passivity. We act and we are acted upon. But how do we balance and mediate these states? How do we cultivate long practices and habits that help us to inhabit the space between activity and passivity, bringing them together in a beautiful agency?Poet and linguist Alysia Harris joins Matt Croasmun for a discussion of that space between active and passive in human life—bringing the concepts of wonder, awareness/attention, patient receptivity to the natural world and to God, bearing witness to the autonomy and action of the other, and how she cultivates and meditates on these things in her own life.Show NotesNorman Wirzba, This Sacred Life: Humanity's Place in a Wounded WorldActive life vs passive lifeIntermediate category between activity and passivity: attentive awarenessActive receptivity and bearing witnessHuman beings enacting and reactingWitness as perception and responseCarl Sagan, Robin Kimmerer, Timothy WilburnWonder as a mediating emotion between active and passive"I'm not the entire system."Granting autonomy to a natural systemMaking the right impact through granting the sovereignty of the otherAdam and Eve as gardeners—beauty vs productivityGenesis: "Avad and Shamar"—Till and Keep, Serve and ProtectRestrain, observe, attend, and magnify"Me and God"Capitalism, scarcity mentality, and "enough"Ping-ponging between over-worked and over-entertainment—deficient visions of activity and deficient visions of passivityMark 4: Parable of the Sower. Scattering SeedsDynamic reciprocity and intentional permeabilityThe patience an orchid demands"Ideas have no use unless they have something to do with our lives."Practices and rituals to inhabit the space between active and passiveWriting habits—"faithful stewardship with less brings faithful stewardship with more"Dance as an embodied balance with intellectual workIntercessory prayer and producing opportunitiesWorking out of hope instead of strivingRunning, walking, granting the natural world autonomyAbout Alysia HarrisFollow Alysia Harris @PoppyinthewheatAlysia Nicole Harris was born in Fremont, California but grew up in Alexandria, VA and considers herself on all accounts a member of the ranks of great Southern women. At age 10 she wrote her first poem, after hearing about sonnets in English class. That class began her life-long love of poetry and the literary arts.Alysia went to The University of Pennsylvania where she experienced her first success as a writer and a performer. In 2008 she featured on the HBO documentary: Brave New Voices where she wowed audiences with her piece "That Girl". In 2010 Alysia graduated UPENN Summa Cum Laude with honors and was also inducted into the Phi Beta Kappa honor society. Alysia received her MFA in poetry from NYU in 2014 and her PhD in linguistics from Yale University in 2019. Her dissertation “The Non-Aspectual Meaning of African-American English ‘Aspect' Markers” breaks with traditional analyses and explores the discourse-oriented uses of the preverbal particles ‘be' and ‘done' in varieties of African-American English.Although she has experienced scholastic success, poetry has always come first in her heart. Cave Canem fellow, winner of the 2014 and 2015 Stephen Dunn Poetry Prizes, Pushcart Nominee, her poetry has appeared  in Best American Poets, Indiana Review, The Offing, Callaloo, Solstice Literary Magazine, Squaw Valley Review, Letters Journal, and Vinyl Magazine among others. Her first chapbook How Much We Must Have Looked Like Stars to Stars won the 2015 New Women's Voices Chapbook Contest and is available for purchase on site.Alysia was also a founding member of the internationally known performance poetry collective, The Strivers Row and has garnered over 5 million views on YouTUBE. She has toured nationally for the last 10 years and also performed at the United Nations and the US Embassies in Jordan and Ukraine, as well as in Australia, Canada, Germany, Slovakia, South Africa, the UAE, and the UK.Alysia now lives in Atlanta, GA where she works as a consultant for the Morehouse Center for Excellence in Education and as arts and soul editor at Scalawag Magazine, a nonprofit POC-led, women run media organization focused on Southern movement, community, and dissent. She is working on a book of poems and a collection of essays about the intersections of faith, violence, and the natural world. Production NotesThis podcast featured poet Alysia Harris and biblical scholar Matt CroasmunEdited and Produced by Evan RosaHosted by Evan RosaProduction Assistance by Martin Chan & Nathan JowersA Production of the Yale Center for Faith & Culture at Yale Divinity School https://faith.yale.edu/aboutSupport For the Life of the World podcast by giving to the Yale Center for Faith & Culture: https://faith.yale.edu/give

Hankering for a little ancient wisdom? Aren't we all. This week, Dr. Akil Palanisamy weaves Ayurveda, western medicine, the gut, and plant based diets into an integrative practitioner's dream! Each Thursday, join Dr. Raja and Dr. Hadar, board certified dermatologists, as they share the latest evidence based research in integrative dermatology. To learn more about increased intestinal permeability in dermatological disease and metabolic syndrome, attend Dr. Palanisamy's lecture at the 2021 Integrative Dermatology Symposium.   Akil Palanisamy, MD is the author of the bestseller "The Paleovedic Diet - A complete program to burn fat, increase energy, and reverse disease." Dr. Akil studied biochemistry at Harvard University, received his medical degree from the University of California, San Francisco, and completed his residency at Stanford University. He also completed a fellowship in integrative medicine with Dr. Andrew Weil at the University of Arizona and is certified by the Center for Mind-Body Medicine at Georgetown University.

In this episode, we chat to Clem Rowe, Managing Director at IPI Packers who are a leading designer and manufacturer of down-hole products with distinctly different inflatable packer technology. These inflatable packers can be used in mining for rock burst mitigation, block caving hydro-fracture, remote or deep permeability testing, rock-stress testing and also custom-made solutions to fit your requirements.   Clem has over 30 years of experience in the design and manufacture of inflatable packers and discusses how their products are used and can benefit the mining industry in a variety of ways.   KEY TAKEAWAYS The best way to think of an inflatable packer is as a balloon on a stick, that can be inserted into a hole and inflated. Inflatable packers are an especially flexible, strong, durable, and often easy to deploy form of packing. Permeability testing is one of the largest uses of inflatable packers within the mining industry. They can also be used for pre-conditioning. Inflatable packers are also a good fit for solution mining. During the podcast, Clem explains the benefits of their innovative Standard Wireline Packer System (SWiPS®). IPI´s unique software package enables them to predict what will happen when their system is applied and plan accordingly. Even with CoVid,IPI Packers turnover has doubled. They are continuing to expand fast with new facilities opening across the globe.     BEST MOMENTS ‘We´re doing our best to prove that our inflatable packers are the best high-performance choice in all applications. ´ ‘It uses water to inflate the backhoe instead of gas.' ‘Every product we produce is in some way an innovation.'   EPISODE RESOURCES Website: https://www.inflatable-packers.com/IPI/index  LinkedIn: IPI Packers | LinkedIn  Facebook: https://m.facebook.com/IPI-Packers-546485666271740/  Twitter: https://twitter.com/ipipackers    VALUABLE RESOURCES mailto:rob@mining-international.org  https://www.linkedin.com/in/rob-tyson-3a26a68/  http://www.mining-international.org  https://twitter.com/MiningConsult  https://www.facebook.com/MiningInternational.org  https://www.youtube.com/channel/UC69dGPS29lmakv-D7LWJg_Q?guided_help_flow=3      ABOUT THE HOST Rob Tyson is the Founder and Director of Mining International Ltd, a leading global recruitment and headhunting consultancy based in the UK specialising in all areas of mining across the globe from first world to third world countries from Africa, Europe, Middle East, Asia, and Australia. We source, headhunt, and discover new and top talent through a targeted approach and search methodology and have a proven track record in sourcing and positioning exceptional candidates into our clients' organisations in any mining discipline or level. Mining International provides a transparent, informative, and trusted consultancy service to our candidates and clients to help them develop their careers and business goals and objectives in this ever-changing marketplace.   CONTACT METHOD rob@mining-international.org  https://www.linkedin.com/in/rob-tyson-3a26a68/    Podcast Description Rob Tyson is an established recruiter in the mining and quarrying sector and decided to produce the “Dig Deep” The Mining Podcast to provide valuable and informative content around the mining industry. He has a passion and desire to promote the industry and the podcast aims to offer the mining community an insight into people's experiences and careers covering any mining discipline, giving the listeners helpful advice and guidance on industry topics. See omnystudio.com/listener for privacy information.

Abundance, Manifesting and Time are themes in this channeled message just in time for the New Moon. Archangel Michael says “Contemplate the ways in which you serve humanity, the ways in which you serve yourself, and the ways in which you protect yourself.”“As you shine your light into darkness it supports everyone. Time is not limited to right now. Fully trust the permeability of time...Your message carries the strength of your awareness. Inside you is a fountain of wisdom, the wisdom of consciousness that flows through… As consciousness flows through you, you flow through consciousness As you flow through consciousness, it pours forth in everything that you say and do… And when you just take a moment to connect a little deeper and listen for more guidance, you might learn something about the bigger picture that just wasn't apparent before. When you connect to this bigger picture, you fall into the arms of grace.”Fall Specials - I offer Psychic Readings, Custom Paintings, Healy Frequencies, Reiki, Reiki Trainings, and Animal Readings. Fall specials include: Custom Paintings are half off at $450, Healy Frequencies are $50, and Animal Readings start at $75. Visit: SarahRossiter.com/sessionsRate and Review Giveaway - I'm offering a free registration to my course Creativity and Consciousness that starts on Oct 1. This is a $1299 value. Or you can choose to receive an original painting by me and a 30 minute psychic reading. A value of $1100. On iTunes you can rate this podcast and write a review - take a screenshot and send it to me and you will be entered to win. This month the drawing is going to be on the full moon of Sept 20. Send your review screenshot to: bookings@thepsychicartistpodcast.comAnd thank you for your support, it means so much to me and helps to share this podcast with a larger audience.Two Free Online Presentations in September:Money and Creativity with Brad Yates - Friday, September 10 at 12pm PST/3pm EST. We will be tapping on allowing more money for creative people. Join live: Facebook.com/TapWithBradHeal, Clear, and Release to Improve Your Creativity with Rebecca Packard and Marisa Imon - Friday September 24 at 9am HST/12pm PST/3pm EST. We will talk about how to heal trauma, clear energy, and release anything not supporting your creative process. This opens you up to manifesting more abundance and ease in your life and work. Find out more at: SarahRossiter.com/trainingsCreativity and Consciousness - Allow the bright and light energy of creative fire to flow through you. Are you ready to make the work that has been calling to you? Join this 10 week interactive live video course and connect to your creative source. Tap into consciousness and find your authentic voice, through any creative medium. Guest speakers include Author Mark Gober, Creative Entrepreneur Laura Michelle Powers, Tapping Expert Brad Yates, Emotion Code Practitioner Rebecca Packard, Singer/Songwriter Marisa Imon, and Intuitive Shelley Wasicki-Franke. Starting October 1st on Fridays at 9am HST/12pm PST/3pm EST. Payment plans are available, for as low as a $111 a month. Sarah Rossiter is an artist, writer and psychic medium.Website: SarahRossiter.comInstagram: SRossiterStudioFacebook: The Psychic Artist PodcastEmail: bookings@thepsychicartistpodcast.comThanks for listening to The Psychic Artist Podcast. If you've enjoyed this episode, please leave a review and share!

The Society of American Military Engineers (SAME) Denver Post and Philadelphia Post along with the US Environmental Protection Agency (EPA) are hosting a series of webinars based on talks given at recent Design and Construction Issues at Hazardous Waste Sites (DCHWS) Symposiums. The mission of the DCHWS symposiums is to facilitate an interactive engagement between professionals from government and the private sector related to relevant and topical issues affecting applications of engineering and science associated with cleaning up hazardous waste sites. The symposiums also serve as a platform to facilitate the exchange of information, encourage dialogue, share experiences, and build and enhance communication among design and construction professionals. Fractures have enabled or enhanced remediation of soil, groundwater, and bedrock for decades. Advanced hydraulic fracturing methods can predictably deliver remediation amendments to low-permeability formations where amendment delivery via Darcy Flow is unreliable or ineffective. Here we present multiple case studies demonstrating the successful application of hydraulic fracturing to deliver remediation amendments to low permeability sites impacted with chlorinated solvents, which would otherwise require more expensive remedial approaches. These case studies include a range of in situ remediation approaches, with emphasis on chemical oxidation and chemical reduction. Implementation costs and performance monitoring results will be presented to demonstrate the potential for hydraulic fracturing to limit project costs and drive remediation outcomes during treatment of these challenging sites. To view this archive online or download the slides associated with this seminar, please visit http://www.clu-in.org/conf/tio/DCHWS18_071421/

The Society of American Military Engineers (SAME) Denver Post and Philadelphia Post along with the US Environmental Protection Agency (EPA) are hosting a series of webinars based on talks given at recent Design and Construction Issues at Hazardous Waste Sites (DCHWS) Symposiums. The mission of the DCHWS symposiums is to facilitate an interactive engagement between professionals from government and the private sector related to relevant and topical issues affecting applications of engineering and science associated with cleaning up hazardous waste sites. The symposiums also serve as a platform to facilitate the exchange of information, encourage dialogue, share experiences, and build and enhance communication among design and construction professionals. Fractures have enabled or enhanced remediation of soil, groundwater, and bedrock for decades. Advanced hydraulic fracturing methods can predictably deliver remediation amendments to low-permeability formations where amendment delivery via Darcy Flow is unreliable or ineffective. Here we present multiple case studies demonstrating the successful application of hydraulic fracturing to deliver remediation amendments to low permeability sites impacted with chlorinated solvents, which would otherwise require more expensive remedial approaches. These case studies include a range of in situ remediation approaches, with emphasis on chemical oxidation and chemical reduction. Implementation costs and performance monitoring results will be presented to demonstrate the potential for hydraulic fracturing to limit project costs and drive remediation outcomes during treatment of these challenging sites. To view this archive online or download the slides associated with this seminar, please visit http://www.clu-in.org/conf/tio/DCHWS18_071421/

Whether you need a spacious family tent or something smaller for you and a friend, you'll love the options available at White Star Outdoors. Grab a bargain at: https://whitestaroutdoors.com (https://whitestaroutdoors.com)

Whether you need a spacious family tent or something smaller for you and a friend, you'll love the options available at White Star Outdoors. Grab a bargain at: https://whitestaroutdoors.com (https://whitestaroutdoors.com)

Wherever you live, there are cycles unfolding in the natural world around you. Creatures, plants, minerals, atoms, celestial bodies…. they express their own presence in unique ways. Besides being glorious to witness, this biological activity has an impact on our environment and on our bodies. By bringing our awareness to these waves of life force, we can amplify the beneficial effects they have on us, including the stimulation of our own evolution. Imagine being able to use your body to directly explore creation and consciously enter into the process of your own metamorphosis!In this episode we focus attention on several aspects of our developing energy system in order to increase bioplasmic permeability so that we can come into deeper resonance with the life force around us. By working through previously covered components like proprioceptive exercise, the outerbody layers and cranial bone movements, frequencies expand to open passageways into a wider range of experience. There is a special focus on working with the bioplasmic membrane and the importance it has on our health and well-being. Here are some related materials about light body activation:Watch a short video on the cranial bone movements to support your work with the cranial bones: Cranial Bone Movements VideoDownload free booklet by Saul Goodman: Light Body Activation - a portal to decentralized spiritual growthWith this podcast you can access and regulate your developing light body. Within it are the keys to vast dimensions of information and adventure. It's free, it's healthy, it's fun, and you can enter into it whenever you want from wherever you are.Please leave a review wherever you listen to your podcasts in order to help support out show. This gives us valuable feedback & helps others find us. Also, you are welcome to share this with friends, family and colleagues who are interested in self-development and health. 

Periods of chronic stress can precede gut problems and often be their cause or a major contributing factor. Learn about the physiological mechanisms involved in stress-induced gastrointestinal issues or flares of existing problems like diarrhea, constipation, acid reflux, SIBO, candida, dysbiosis, leaky gut, IBS and IBD and ways to combat and reduce chronic stress for better gut health. Lindsey Parsons, your host, helps clients solve gut issues and reverse autoimmune disease naturally. She's a Certified Health Coach at High Desert Health in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on Facebook, Twitter, Instagram or Pinterest or reach her via email at lindsey@highdeserthealthcoaching.com to set up a free 30-minute Gut Healing Breakthrough Session or a 1-hour initial consultation. Show Notes

It was Hippocrates, the Father of Medicine, who said, “All disease begins in the gut,” nearly 2500 years ago. He was onto something, because many metabolic, autoimmune, and cognitive diseases share one thing in common… a leaky gut. Dr. Martin discusses two studies in today's podcast that show the dangers of gut permeability. He explains how there's an invisible war going on in your gut. We have a thin lining of epithelial cells in the gut, and when this barrier is gone, excess permeability is caused… which is leaky gut! Listen to today's podcast to learn the 3 things causing gut permeability, and what you can do to fix the problem! A hint… it starts with food!  

Nikki and Matt discuss gut health, gut permeability & the hormone Zonulin. When we add toxins to our bodies through food, environment, and stress, it is creating an overproduction of the hormone Zonulin. Zonulin is a protein that modulates the permeability of tight junctions between cells of the wall of the digestive tract. These toxins and stressors are causing permeability in our gut and leading towards an inflammatory response. When we increase inflammation, we increase our immune response which is leading to autoimmune conditions. Learn about ways to control this response and improve our health by removing the toxins in and around us. About Nikki Burnett Nikki works with ambitious professionals to help them overcome hidden barriers to both health and success. What many people don’t realize is challenges such as chronic stress, brain fog, low energy, and stubborn chronic issues frequently have their root in unhealthy foods and unknown inflammatory conditions. I help people tailor their food to their unique biochemical makeup and lifestyle needs so they can feel great, thrive, and do more of what they love. Functional nutrition is based in the science of functional medicine. The goal is to understand the body through functional lab testing, genetic testing, environmental factors, stress, and lifestyle. Nikki works with a number of different conditions including: • Fertility (men & women) • Hormonal balance (men & women) • Gut dysfunction • Autoimmune conditions • Blood sugar balance • Cardiovascular health • Weight management • Nutrigenomic analysis • General health & wellness • Canine nutrition Nikki Burnett, MS MNT CNTP Functional Nutritionist Training through The Institute for Functional Medicine Taste Life Nutrition 303.929.8926 Nikki@TasteLifeNutrition.com TasteLifeNutrition.com

This week it's all about permeability - how water flows through rocks! Fun Paper Friday Yam, Kai Chi, et al. "Association of high profile football matches in Europe with traffic accidents in Asia: archival study." bmj 371 (2020). Contact us: Show Support us on Patreon! www.dontpanicgeocast.com SWUNG Slack @dontpanicgeo show@dontpanicgeocast.com John Leeman www.johnrleeman.com @geo_leeman Shannon Dulin @ShannonDulin

Tahnee is back on The Women's Series today for a moving conversation with Dr. Oscar Serrallach, author of The Postnatal Depletion Cure, Integrative GP specialising in women's postnatal health, and devoted father, working passionately to bring more focus on mothers postnatal health into the world. His project The Postnatal Depletion Cure has been inspired by witnessing/treating so many women with chronic postnatal depletion and the lack of awareness this dilemma has, both at a societal and medical level. Dr. Oscar believes mothers are the fabric of our society, and through supporting healthy mothers, we create a healthier world for everyone.  This heart centred conversation is of relevance to everyone. The time to honour and support all mothers, including the great Mother Earth, is now. "We almost forget as a collective that there is no more important job than making another human being, and there is no more important job than teaching that human being how to love, that's a mother's job. As a father, I can teach my kids around the complexities of love, but the actual fundamentals, that starts in the womb and is learned early on, in that house of love".   Tahnee and Dr. Oscar discuss:  The often undervalued role of mothers; Mothers are the centre of society, and as a collective, it's everyone's responsibility to make sure they are well supported. Motherhood in the 21st Century, how far have we fallen? Motherhood has shifted from being a role of central importance to a secondary thing that women add to their already busy lives. Displaced badges of honour; the pressure put on mothers to  get back to work instead of honouring and supporting the transition of the maiden to mother. Brain changes women experience during a single pregnancy and how these fundamental changes relate to cultural beliefs around holding a mother in the postpartum period. The importance of a postnatal care plan. What Dr. Oscar recommends and why. The idea of the super mum; how this term can be detrimental to the health and well-being of mothers. The essential role of the matriarch and the 'grandmother hypothesis'. Why the menopausal years are about giving back and passing on wisdom. The increase in Postnatal Neuro Inflammatory Disorders (postpartum fatigue, postnatal depression, anxiety, obsessive-compulsive disorder). What are the causes? How can we avoid them? Autoimmune conditions during and post-pregnancy. Harnessing the power of the placenta; how this amazing organ and  subsequent pregnancies can provide an opportunity for healing the mother. Nervous system practices to maintain and rebuild a mother's health.  Who is Dr. Oscar Serrallach? Dr. Oscar Serrallach graduated with a medical degree (MBChB) from the Auckland School of Medicine, New Zealand in 1996. He received his fellowship of Family Medicine and General Practice in 2008 and is currently completing a Fellowship in Nutritional and Environmental Medicine. He is the owner and principal doctor at the Mullumbimby Integrative Medical Centre based in Northern NSW Australia, which he has been running since 2011. Dr Serrallach is the author of the groundbreaking book for women The Postnatal Depletion Cure, a programme and book for women that bridges that gap in women’s postanal health, and has brought hope and healing to so many women suffering with postnatal depletion. Dr Oscar Serrallach is dedicated to remaining at the cutting edge of wellness healthcare and continues to advance and bring awareness to the field of women's postantal health. Resources: Dr. Oscar Serrallach websiite The Postnatal Depletion Cure Dr. Oscar Serrallach Facebook Dr. Oscar Serrallach Instagram Q: How Can I Support The SuperFeast Podcast?   A: Tell all your friends and family and share online! We’d also love it if you could subscribe and review this podcast on iTunes. Or  check us out on Stitcher, CastBox, iHeart RADIO:)! Plus  we're on Spotify!   Check Out The Transcript Here:   Tahnee: (00:01) Hi everybody, and welcome to the SuperFeast Podcast. Today I'm here with Dr. Serrallach and we're going to talk about his book, The Postnatal Depletion Cure and his work with women on going and sort of helping them to restore their vitality after having babies, which is a big and beautiful job. So thank you for joining me today.   Dr. Oscar Serrallach: (00:22) Thanks Tahnee, and thanks for the invitation. I really admire your work with SuperFeast and your role in mother care as well. As we know, mothers centre everything and, as a society and as communities, we need our mothers to be as well as possible.   Tahnee: (00:38) Yeah. I loved that right at the beginning of your book where you say ... I'm going to read it, that the well-being of mothers is the fabric from which the cloth of the future of our society is made. I read that and just thought yes, because it sets the framework for our children, how they live, how they raise their children. It's just a cascade.   Dr. Oscar Serrallach: (00:58) It's central and it's primary, whereas I think in this 21st century, motherhood has become decentralised and a secondary kind of thing that mothers just add on to their already busy lives. We almost forget as a collective that there is no more important job than making another human being, and there is no more important job teaching that human being how to love. That's a mother's job. As a father, I can teach my kids around the complexities of love, but the actual fundamentals, that starts in the womb and is learned really early on, just that house of love.   Dr. Oscar Serrallach: (01:44) I think it's useful to kind of reframe that because a lot of mothers feel like they want to stay home and stay in that role, and they're feeling pulled into all the trappings of the 21st century living and jobs and success. We've got a very academic way of kind of even judging one's success.   Tahnee: (02:07) Rationalising. I think a lot of rationalising happens when you become a mother.   Dr. Oscar Serrallach: (02:12) Well, and externalising, comparing.   Tahnee: (02:14) Yeah.   Dr. Oscar Serrallach: (02:14) It can be very tough landscape, especially they're not really that aware of the deep transformation that's kind of occurring within not only mother's kind of psyche, but also within her biology in terms of her brain, her nervous system. Such massive changes occur and everyone's going into parenthood with quite an abstract idea of what they're in for. We talked about Pinterest parenting. It's like you ever go, well, I quite like this and we're going to do this. No, we're not going to do dummies or thumb sucking. We kind of have a checklist of these quite important but not that important issues and actual fundamentals of looking after a helpless human being we don't really have much experience in. We think we'll just kind of wing it.   Tahnee: (03:17) Well, it's funny because there's that old joke where people say, oh you should get a licence to have a child, and there is sort of this element of, culturally, you used to be raised around small children. I see my child and the other children in the street. They kind of raise each other in a way and they learn to be with a smaller person. I can imagine that that gives them this kind of sense that later on they're going to be a little more adapt at handling children when they have their children. I think we miss so much of that because we have these nuclear families and we've lost large families with lots of siblings. That's not really our norm anymore.   Dr. Oscar Serrallach: (03:56) Yeah, that's right. In traditional societies, there's not a way you would have reached the possibility of becoming a parent without significant experience in actually looking after young children and slightly older children. Again, the analogy of the licence. You wouldn't have needed a licence because you've already had a lot of experience. The sort of research of American. The average couple researches more time in buying a new vehicle than they do in actually becoming a parent. So there's often a lot of research in the antenatal pregnancy, but the parenting side of things, we don't ...   Dr. Oscar Serrallach: (04:33) So when I'm making a joke about winging it, that's what we all do, expecting that somehow we'll know what to do or someone's going to turn up and help us.   Tahnee: (04:45) Yeah.   Dr. Oscar Serrallach: (04:48) We can really struggle and suffer when a mother hasn't slept for months and, at 3:00 in the morning, she can't settle baby. Then she's trying to work out what's going on. It's a very deep, dark place to try to pull yourself back from, especially when you don't have a cultural context.   Tahnee: (05:09) Yeah.   Dr. Oscar Serrallach: (05:10) Or even a default place to go, where to get support or ideas, or solutions. As a society, we're very unkind to mothers generally. If there's anything wrong with the baby, who gets blamed? The mom. I think it should almost be the opposite. If there's any issues with the child, it should almost be a collective, ah, the society didn't turn up enough to help that mother for the child.   Tahnee: (05:37) Yep.   Dr. Oscar Serrallach: (05:39) Because I don't meet bad mums. I just meet unsupported mums who have struggled and haven't been supported and were unaware. Most mothers are in it boots and all, so it's not a matter of not trying hard enough. It's just not having the right resources, the right knowledge, the right preparation, or even awareness around the certain times of vulnerability that can occur during motherhood. We almost have the opposite in terms of these badges of honour, the super mum getting back to work as early as possible. Working mums, when they're at work, they're pretending they're not a mother. When they're mothering, they pretend they don't have a job.   Tahnee: (06:31) Fragmentation of self.   Dr. Oscar Serrallach: (06:34) Quite damaging and pretty much impossible because you can't switch off your mother-ness.   Tahnee: (06:39) If only. No, you don't want to. I think when you first ... I certainly remember being a couple of weeks in and being like, oh my gosh, who am I now, because I'm not that person who gave birth to this child and I'm not a mother yet because I don't know that role intimately. It was just this funny little liminal space of I didn't really know who I was becoming and I didn't know who I was ... I sort of knew who I was leaving behind, but there's a grieving period, which happened for me in pregnancy and then again postpartum. It's interesting and there aren't a lot of elders now to even take ...   Tahnee: (07:22) We had an older friend who doesn't have children, and she's raised or helped raise many nieces and nephews. She showed up and swaddled my daughter and picked her up and walked her around a couple of days after I had her. I just was like, whoa, that's cool.   Dr. Oscar Serrallach: (07:36) And so necessary as well.   Tahnee: (07:38) Yeah, because she was friends and close, she just came in and did it. I thought, wow, there's so few women that I know that could help me like that and that sort of can support. I think that's a big part of it, right?   Dr. Oscar Serrallach: (07:52) Yeah. What you're describing very beautifully is that transition from maiden to mother. We can talk about that more, but this idea of matrescence, of becoming a mother, is a very profound idea. Many mothers describe this heart ripping experience with those first few days post birth, and that's a real time of vulnerability. One of the most important things that a mother experiences really in that time is safety and that everything is going to be okay, and that her team around her have got this, because she cannot feel the edges anymore and she's getting used to these mother upgrades in terms of nervous system and brain changes and hormones.   Dr. Oscar Serrallach: (08:43) It can take several years to get used to these upgrades. What I like about that story that you were sort of sharing is that you had someone, who probably wasn't even asked to help, turning up and doing what was necessary. That's real support, but in a trusting environment. When a mother is actually having to ask for support, it's already too late because, if she senses she's struggling, she's been struggling for quite a bit of time before she's raising her hand, or she may not feel justified to raise her hand to ask for help or feel that she's doing a bad job, and that she's a bad mom and she should know better, which is part of a negative feedback that we often get culturally around motherhood that you just should divinely know how to be a mother at the birth of a child, and shame on you if you didn't get that sort of download.   Dr. Oscar Serrallach: (09:42) Of course, mothering is a learned skill. As we alluded to before, we don't have the learning prior to becoming mothers often because they're not looking after lots of children and what have you. Then some women learning on the job. In the sense of vulnerability with the massive changes that have occurred and getting a sense that you're not a maiden anymore but you're not a mother yet, this is a classic challenge of matrescence, the becoming of a mother. Who am I? What does my purpose look like? It can be very derailing if that isn't held or there isn't a container to explain the transition.   Dr. Oscar Serrallach: (10:29) This is why I quite like the term adolescence, to compare to matrescence, because that's the only other thing that's comparable. Adolescence, you don't become and adult at your 18th birthday. It's obviously an important time. And you don't become a mother at the birth of your child, even though that's an obviously very important milestone to transformation. We know that adolescence has massive brain changes that occur during adolescence, but there are actually more brain changes that occur during a single pregnancy than for the entire adolescence.   Dr. Oscar Serrallach: (11:10) Again, it takes a few years for the adolescent to get used to their brain and they can seem kind of less human for a short period during that, but literally they start feeling more before they start thinking. That's part of ... and for mothers, it's a very similar thing. They can feel so much more than they ever have before, and their brain is infused with millions of oxytocin receptors that maidens don't have and men don't have. That is one of the critical issues in that early phase. This is why so many cultures have such deep cultural beliefs and teachings around holding mother in that early time because, if you think about it, oxytocin not only is the hormone of childbirth in all the contractions of the uterus, but it's also the hormone of skin to skin contact, intimacy, trust and safety.   Dr. Oscar Serrallach: (12:08) So essentially, the way I'm interpreting the research is that a mother's stress response system has gone from her previous me, am I safe, am I okay, to this oxytocin infused we. Are we safe, are we okay, does this make sense for us? That can sometimes be ... That is what the baby bubble is, but it also can sometimes extend way beyond the baby. Sometimes it can be the family unit. Sometimes it can be the community. Sometimes it can be the world. That is a very raw feeling that mothers can have. I hear so many mothers, they can't watch the news anymore, they cry at commercials. Their ability to be able to tolerate things really changes.   Dr. Oscar Serrallach: (12:53) They can feel like an alien at their workplace, whereas obviously their workplace hasn't changed at all. They have changed. So they're having to ... They are in a liminal space for a while, but the challenge is in the reintegration. One that their liminal space is allowed to go through its force of process, and this is what those cultural practises are essentially around. Then just to have a healthy reintegration. Otherwise, it can be quite destructive on some levels in terms of the mother's sense of self and her psyche and her emotional well-being. She knows that she's different, but no one's told her that she's going to be different.   Dr. Oscar Serrallach: (13:41) Trying to deal with that dissonance alone, it's fraught with problems. So a mother suffering on her own is one of the worst things ever really. I think, as a society, that would have never happened in antiquity. Then we're seeing it happen all the time now. We're even seeing sub nuclear families now.   Tahnee: (14:10) Yeah.   Dr. Oscar Serrallach: (14:10) So intentional single parenting. Mothers who aren't having a primary partner, having children, so they have even less support than the overwhelmed nuclear family. I see a lot of mothers having to lean on their partners for emotional support, whereas traditionally a partner would have only been doing a small part of that.   Tahnee: (14:33) Yeah.   Dr. Oscar Serrallach: (14:34) And the mother could have leaned on so many other people, including aunties and grandmothers and sisters, and really be held deeply with a lot of experience. Yeah, so it's definitely a journey that's fraught with challenges. I think as a collective, and I think this is where you and I have a lot of overlap, is that we understand that. From a traditional Chinese medicine point of view, that's actually well described over many millennia that this potential vulnerability is there. As a collective, we have to make sure that mothers never go there wherever possible and support them as much as possible.   Dr. Oscar Serrallach: (15:20) A big part of my recent work is not only sort of helping mothers with postnatal depletion and other neuro inflammatory disorders, but actually to do really good postnatal planning.   Tahnee: (15:31) Yeah.   Dr. Oscar Serrallach: (15:32) To avoid the pothole in the road. If you can see it, then you can drive around it.   Tahnee: (15:37) Totally, because so much work goes into birth plans. I can't remember how many people asked me about my birth, like every second person. Postpartum, nothing.   Dr. Oscar Serrallach: (15:50) Yeah, and if you can imagine having half the amount of energy that went into the birth plan going to your postnatal plan, and then enabling a team of people to enact it, because I think part of the ... Like the birth plan, a mother is in a liminal space during birth and she's in a very vulnerable space post birth. She shouldn't be the one enacting the birth plan or enacting the postnatal plan. She should have agreed on what it looks like and then things are happening without her having to really sort of focus on that, because that can be very challenging for a mother to kind of try to be an advocate in that birth space when she's in such an oxytocin infused vulnerable space, or to even have ...   Dr. Oscar Serrallach: (16:43) She's often in such a time dilated baby bubble that it can be really hard to pull herself out of that to kind of negotiate-   Tahnee: (16:53) A timeframe or delivery schedule, yeah.   Dr. Oscar Serrallach: (16:53) ... food rosters, yeah.   Tahnee: (16:53) What day is it? Who am I?   Dr. Oscar Serrallach: (16:54) Yeah, whose plate does this belong to.   Tahnee: (17:00) Totally.   Dr. Oscar Serrallach: (17:01) And having to get stressed out by detail. So part of the birth plan is to enable the guardians. So they can be dads or other primary caregivers, and really give them the keys to the car, so to speak, so they're not having to keep on asking mom is it okay if we do this. What about just things that are happening?   Tahnee: (17:25) Which I guess is sort of an impetus to articulate how you like to be supported. I think that's something where ... Certainly I'm speaking for myself and some friends that I've spoken to this about, but it can be hard to know what you need in that time, especially if you're a first time mum. I think if it's second or third ... I've had friends with a second baby who are like, all right, you're in charge of the food roster and you're in charge of this. They kind of knew what they would need.   Tahnee: (17:51) So in your book, you speak about just the basics of getting enough sleep, good nutrition, those kinds of things. If someone is thinking about what's my postnatal care plan, what are the things that you think are essential to have on there?   Dr. Oscar Serrallach: (18:06) Yeah. So I talk about one month of deep rest, 100 days of deep support, and then priority on sleep for one year. So, that's kind of just some of the themes. I really try to enable the guardian, so the dads or the other primary caregivers, to be free of other duties. Their main job is to focus on the mother. Not focusing on the jobs that need to be done. We talk about visitors only start. If anyone's coming over, they've eventually got jobs to do.   Tahnee: (18:42) Mm-hmm (affirmative).   Dr. Oscar Serrallach: (18:44) To give them permission to do as little as possible. As we know with TCM and setting the moon, in traditional Chinese culture, the mothers are allowed to do essentially nothing. They're allowed to go to the toilet, feed the baby, feed themselves and that's it. Some places are not even allowed to shower in the first month. If you're seen with a newborn baby out on the street, in traditional China, you're going to get shooed back into your home pretty quickly.   Tahnee: (19:15) Yeah, by one of those aunties.   Dr. Oscar Serrallach: (19:21) Yeah, yeah. Well, meaning they're quite full on aunties, yeah. Whereas we don't have that context or those sort of boundaries here. There are other things I sort of talk about with sort of postnatal planning is ... I think the food roster is just a great way. So again, food preferences, those kinds of things, email a group, WhatsApp group, whatever it looks like. Then the mother doesn't get involved.   Tahnee: (19:46) Yeah.   Dr. Oscar Serrallach: (19:46) Food's arriving. If somebody can't deliver, you've got your backup in the freezer, whatever. Mother doesn't even know. She's not having to kind of be pulled out of the baby bubble. I think social media is a really big trap, especially for the social media inclined. You want to show off your joy to the world, and I totally get that, but have that for four weeks, social media silence. That would be an accepted norm.   Dr. Oscar Serrallach: (20:21) For the baby and the mother and the birth weight and everything went well. See you in four weeks.   Tahnee: (20:27) But you even talk about that, that focus on the birth weight, the stats and the kind of ... I remember reading that in your book. It's like there's this real emphasis on that, and then there's kind of just this like, great the baby is here. Forget about mom. Then it becomes baby, baby, baby, baby, baby, baby, baby.   Dr. Oscar Serrallach: (20:46) Yeah, and this was my personal experience. If the spotlight that had been so beautifully on mother during the pregnancy suddenly just disappears and suddenly, hang on, everyone's forgotten about her. I think is a collective ... that's literally what we've done. We're not honouring mothers and we're not honouring the great mother obviously in terms of what we're doing with global pollution and climate change. Who better to enable that change? I think mothers are able to teach children about being agents of change, and this is why we need mothers who are really just grounded, who are well in themselves, who reengage with their purpose.   Dr. Oscar Serrallach: (21:33) I call it the birth of the lioness's idea that, once a mother's at a vulnerable kind of stage with her mother upgrades in terms of all these extra brain neurons and receptors, and altered sort of stress responders and hormones, that she's actually got super powers that she didn't have before. She cares more than she ever has, and she'll often care about others more than she cares about herself. That's a gift and a curse, but the gift part of that is we need that sort of energy in all aspects of education, medicine, politics.   Tahnee: (22:12) Life.   Dr. Oscar Serrallach: (22:13) Life. I keep coming back to the fact that there are 10 countries in the world that are governed by mothers, by women. Five of them at least, possibly six, are mothers from what I can see. 193 countries governed in the world, so it's a very small percentage, but are the countries that are doing the best from a COVID-19 point of view. Of those 12 countries governed by women, seven of the top 10 in terms of COVID stats are governed by women. Statistically, that's outrageous in terms of the correlation there. I think partly it's a culture that enables females to be prime minister's and it's also that those cultures are obviously more evolved.   Dr. Oscar Serrallach: (23:04) Then you've got people in places of power who care a whole lot, and that sounds quite obvious, but we're in a pretty low care political system.   Tahnee: (23:18) But I think that ... I think what I've read in your book, and I'm hoping I'm getting this right, but it's like we need to wait a while. We need to wait until the kids are a bit older before we're sort of ready to express that super power. Would that be fair to say? I feel for me, my daughter is nearly four, and it's really time for me to step back from my leadership role and to give that over. Then there'll be a time when she's a bit more independent when I come back into that with that sort of gathered wisdom.   Tahnee: (23:47) But that pressure to stay on and run the company and all those things, I've really had to drop that over the last four years. It's something that I can feel that I'm capacitated, but I can also feel that my priorities are elsewhere. I think I need to honour that shift in priority. So I wonder if you could talk to that. I know your wife was quite a go getter from what I sort of-   Dr. Oscar Serrallach: (24:08) Yeah.   Tahnee: (24:09) She's now the mum of three, so I imagine things have changed dramatically for her. So what's your sort of take on that shift? I watched Lucinda Ardern. She's just had a baby and she's running a country.   Dr. Oscar Serrallach: (24:21) Yeah.   Tahnee: (24:21) That's not very good in my mind.   Dr. Oscar Serrallach: (24:21) Well, from a postnatal depletion point of view, I was like ... I think she must have gotten pregnant around the time of winning the election from what I can kind of gather.   Tahnee: (24:32) Yeah.   Dr. Oscar Serrallach: (24:34) Just doing a little bit of subtraction mathematics. She's had great support.   Tahnee: (24:42) But she also said in an interview she sleeps four or five hours a night, lives on coffee. She's pushing it.   Dr. Oscar Serrallach: (24:48) Yeah.   Tahnee: (24:49) I think that's where this fine line. I remember travelling for three months ... sorry, at three months with my daughter for a month, almost nonstop. It was dreadful. I felt terrible the whole time. I was barely keeping up. It's a totally different game when you have a kid.   Dr. Oscar Serrallach: (25:06) Yeah. Lucinda Ardern is probably quite an interesting example where she is supermom, but the idea of a supermom is actually quite dangerous and it shouldn't be something we're aiming for.   Tahnee: (25:17) No.   Dr. Oscar Serrallach: (25:18) For me, an analogy is it's like driving around without your seat belt on going, look at me, I didn't have an accident. It's like, well yeah, but you should still wear the seat belt. I've often thought about this question, what is the ideal time. I think it's partly dependent on each mum, but when I kind of look at cultural groups, these are first nations or cultures that are still living quite traditionally, the mothers are very involved with a zero to one year old, but then thereafter the grandmother hypothesis. The one to five year old, even the mother is still very involved, the primary care giving is actually by the aunties and the grandmothers.   Tahnee: (26:03) So that hypothesis, just for people that don't understand, is that the menopausal years are really about giving back to the community in service of raising children, and that the younger mothers were actually doing a lot of the physical work to keep the community going?   Dr. Oscar Serrallach: (26:19) Exactly. We're only one of two species that has menopause. Apes, for example, they just become less fertile until death.   Tahnee: (26:31) Yes. Is it whales and us?   Dr. Oscar Serrallach: (26:31) Orca whales, yeah. There's probably one other whale that you're thinking about, but they know exactly why orcas have menopause at 30. So they're fertile from 15 to 30 and then they can live up to 80.   Tahnee: (26:42) Wow.   Dr. Oscar Serrallach: (26:43) So these matriarchs pass on cultural knowledge and they learn seasonal changes. So they've studied orcas. It's a bit weird that they have a hypothesis for humans, but ... I think part of the programme, stopping of the ovaries at 15 and menopause is around, suddenly that cultural knowledge becomes more important than fertility and offspring, because you're supporting direct genetics.   Tahnee: (27:15) Lineage, yeah.   Dr. Oscar Serrallach: (27:15) Anyway. So it's investing in grandchildren and the great grandchildren, as opposed to more children. Because there can be so many seasonal changes, and then changes with climate that could occur naturally anyway, it's very important to have that flexibility. That can take a long time to learn. So grandmothers have a really important role. Again, we would have had children much younger.   Tahnee: (27:49) Yeah.   Dr. Oscar Serrallach: (27:49) The average age in Australia, one of the oldest countries in the world, 30.9 is the average age for your first child. Now that would have never happened in prehistory. That wouldn't have been the age of your first child. In this culture, we've had these deep practises to get mother back on board that first year. Baby bonding, really just focus on baby, and then she's kind of released from her role. So we need at least a year, but the effects of not allowing the hormonal system to recalibrate can cause neuro inflammation, which basically all the problems postnatally that we know about, postpartum fatigue, postnatal depression, all the mood disorders including anxiety and obsessive compulsive disorder, they are neuro inflammatory in nature, which are very different to men and maiden for similar symptoms. They're a unique group.   Tahnee: (28:50) Mm-hmm (affirmative). So you're saying postpartum, all of those symptoms or syndromes can be traced back to this inflammation of the brain.   Dr. Oscar Serrallach: (28:59) Yeah.   Tahnee: (28:59) Yeah, okay.   Dr. Oscar Serrallach: (29:00) It's a very tiny part of the brain. The research in the last few years has really increased in understanding of which parts of the brain and what you can potentially do about it is just really starting. So this idea of neuro inflammation is quite ... It's not new, but the idea with mothers in terms of as a community and as doctors and healers, this idea is relatively sort of new. It makes a lot of sense. The pattern fits exactly with what anyone sees clinically or if you're watching mothers kind of struggle with depression or fatigue, you realise this is not just stock standard symptoms.   Tahnee: (29:47) Yeah.   Dr. Oscar Serrallach: (29:47) There's something very different or unique going on. So with that neuro inflammation, that can last for years and years afterwards. The peak incidence of depression after a child is four to five years after birth of a child but, because it's outside the six months definition, they can't call it postnatal depression. They have to call it depression postnatally. So it just shows you there's an accumulation of factors that can occur.   Dr. Oscar Serrallach: (30:20) When they do electrical scans of a mother's brain who has depression, they look very different to a maiden's brain who has the same symptoms. We shouldn't be calling these conditions postpartum depression, postnatal anxiety. They should actually be postnatal neuro inflammatory disorder.   Tahnee: (30:44) Yeah. The implication is you're not going to treat them with antidepressant in the same kind of treatment, right?   Dr. Oscar Serrallach: (30:51) It just happens that some of the antidepressants have an accidental effect on neuro inflammation through something called gabber.   Tahnee: (30:57) Oh yeah.   Dr. Oscar Serrallach: (30:58) Not through serotonin, which is ... Serotonin often takes two weeks for these medications to start working. If one of these serotonergic agents has this accidental gabber effect, you can start getting benefits within two to three days.   Tahnee: (31:14) Okay, but then herbs like Mucuna and things that work on gabber as well are going to be beneficial, right? Yeah.   Dr. Oscar Serrallach: (31:20) One thing just to be aware of regarding that is the first ever approved drug for postpartum depression came out last year in America. It's not available in Australia.   Tahnee: (31:30) I saw it, yeah.   Dr. Oscar Serrallach: (31:31) Yeah, it's a pretty big topic, but I think what's profound about it is it's not actually a drug as much as a repurposed placental hormone that's been tweaked and infused into the mother who has depression, anxiety, can't look after herself. It essentially switches off that neuro inflammation within 12 hours typically.   Tahnee: (31:59) Wow.   Dr. Oscar Serrallach: (31:59) So pretty profound that one hormone can help a psychiatric condition, or that a hormone or anything can switch off a psychiatric condition, because that's relatively new ground. Normally you'd be managing or treating, not switching off. They give it as an infusion over 60 hours and mothers usually don't relay need any treatment after that.   Tahnee: (32:24) Wow.   Dr. Oscar Serrallach: (32:25) It's very expensive. It's not available in Australia, and I'm sure the pharmaceutical industry is going to do what it does and try to push it out to every mother who is struggling. But the idea is the unique landscape of the mother's brain, that this intervention probably wouldn't make much difference for a man or a maiden with the same symptoms. So if we can just really feel how profound that idea is, it's actually totally different. Anyone who works with mothers senses that. I think the science is just giving us permission to treat mothers differently, and it also is giving us an imperative that mother care is super, super important.   Dr. Oscar Serrallach: (33:17) I think one of the aha moments for me was looking at traditional Chinese medical texts when they described what happens to a mother who isn't supported. Even though the language is very different to what the concept of that a mother can be left in this fragile, nervous, depleted state ongoing, that's been known about for thousands of years. Hence the elaborate cultural practises and bullying by well meaning aunties because it's become-   Tahnee: (33:59) They observed that and they found solutions, which is science really. It's replicable over time and we're watching generations of women benefit from that. But then we don't really want to adopt those practises necessarily in our culture because it feels like who's going to ... Even the binding and all of those things, it's so rare that that's-   Dr. Oscar Serrallach: (34:22) It can almost seem antifeminist as well.   Tahnee: (34:24) Yeah.   Dr. Oscar Serrallach: (34:26) This is some of the feedback that I've certainly got from my mothers. What's quite cute for me is all my medical software that I use with pregnant mothers, it still has the initials EDC on there, estimated date of confinement. So it's alluding back to kind of the Victorian idea that mothers needed to be confined. Of course that seems quite-   Tahnee: (34:50) Antiquated.   Dr. Oscar Serrallach: (34:50) Yeah. That's very antifeminist, but the idea is that the confinement was a necessary part of the care. Then the confinement kind of occurred in hospitals, and then we just forgot about the confinement. Off you go, do what you want, good luck.   Tahnee: (35:12) Yeah. I've always said feminism has a lot to answer for because I think even some of those concepts of supermom and that comparison of ... I used to say I'll just bring my daughter to work. It'll be fine. I think there was this programing, I suppose, around my own upbringing and what I'd sort of witnessed in media and my friends and peers. It seemed like they kind of had the baby and they maybe disappeared for a month and then they were back to normal, in inverted comma's invariably not.   Tahnee: (35:44) But you talk about all of these things that come up. You talk in your book about treating women four years down the track that have all sorts of debilitating, whether it's anaemia or things like chronic colds and flues.   Dr. Oscar Serrallach: (35:57) Fatigue.   Tahnee: (35:58) Fatigue.   Dr. Oscar Serrallach: (35:58) Sleep problems, emotional health.   Tahnee: (35:59) Yeah, and it's like that's still happening.   Dr. Oscar Serrallach: (36:00) yeah.   Tahnee: (36:02) It's almost normalised. So many of my mom friends would just sort of accept that you're tired all the time and your brain doesn't work properly, but I don't know that that's ... When I'm really careful, I actually feel really good, but I have to have very strong boundaries and really take responsibility for my health as a priority over anything else I do. I think that's the sense of we normalise this business and this kind of deep fatigue and exhaustion, but it's really not normal. It's what everyone does.   Dr. Oscar Serrallach: (36:33) Well, what's common. So what is normal and what is common. 50% of people get cancer in their lifetime, so that's pretty common. You cannot convince me that cancer is normal. Many conditions alike, diabetes 50% rate past the age of 50, heart disease. It's so common that they're normalised. America is interesting that it's often four or five years ahead of what the statistics show in Australia. Currently in America, and I'm expecting to see this in Australia in four to five years time, is the rate of PMS or perinatal mood and anxiety disorder. That can be depression, anxiety or obsessive compulsive disorder, is 40% within that first three to six months.   Tahnee: (37:24) Wow.   Dr. Oscar Serrallach: (37:25) So that's ... it was 30, 20%, and we're seeing ... It's not that the diagnosis is getting better or more-   Tahnee: (37:36) More sensitive, yeah.   Dr. Oscar Serrallach: (37:38) It's just we're having more mothers that are just struggling and strung out, and really just pushed beyond their capacity, and then left in this neuro inflammatory state, and then they get the label, and then they get pharmaceutical treatment.   Tahnee: (37:56) Yeah.   Dr. Oscar Serrallach: (37:58) So if you see the rates increasing, we have to then go, well as a collective, are we just okay with that?   Tahnee: (38:07) Yeah, take responsibility as a community.   Dr. Oscar Serrallach: (38:09) Yeah, also just go, okay, the stakes are getting higher. It's not that we're getting softer with each generation. It's just that there's epigenetic change over generations. I think there's more toxins, there's more-   Tahnee: (38:22) Totally.   Dr. Oscar Serrallach: (38:23) The modern woman doesn't have any downtime, whereas the ancient woman had a lot of stress for sure, but she had a lot of downtime as well. Times of boredom, times of just relaxation. The modern 21st Century woman and the modern mother, it's 24/7. She just keeps peddling, keeps peddling, and isn't supported to not do that. Then the expectation is that's what a mother does. Why you can blame her. You wanted the child. You've got a healthy ... The negative feedback that a mother gets if she is struggling is terrible. The judgement from well meaning others.   Tahnee: (39:05) Yeah, the undermining of their experience.   Dr. Oscar Serrallach: (39:07) Then a mother then judges herself, and then she starts undermining her own abilities. She may also pass it onto the next generation, this idea of the mother wound where intergenerational we can pass on the non supportive mothers. It doesn't have to be directly from your own mother. The mother wound is really about a cultural norm.   Tahnee: (39:34) Collective, yeah.   Dr. Oscar Serrallach: (39:36) I wasn't supported. I wasn't allowed to shine my light. Why should you? That's part of the unspoken energy that sort of can happen in between generations. Yeah, it's devastating.   Tahnee: (39:51) It comes back to mother care, which is this essential what you do. So we're talking ... You mentioned a lot the autoimmune factor. I think, when I was pregnant, I was reading about how the baby's cells end up in the mother's heart or her brain or long after the kind of sharing a space.   Dr. Oscar Serrallach: (40:13) Yeah.   Tahnee: (40:13) Which still blows me away sometimes. There was a baby in my belly. But yeah, that can lead to really drastic immunological ... it can have a really positive effect, I've read. It can have these sort of ... I know people who have not been able to eat gluten before and suddenly have great digestion and don't have those inflammation responses, but then it can go the other way too, right?   Dr. Oscar Serrallach: (40:33) Yeah. This is the-   Tahnee: (40:35) Opportunity and curse, I guess.   Dr. Oscar Serrallach: (40:37) Well, it's placental inflammation really. You need some inflammation, but too much inflammation during pregnancy, the immune system can get quite stressed. Essentially, most autoimmune conditions, apart from Lupus, improve-   Tahnee: (40:56) During pregnancy.   Dr. Oscar Serrallach: (40:57) During pregnancy. Mothers can feel amazing during pregnancy. Not all mothers, but because of progesterone and some of those other hormones. Then, once the placenta is delivered, you're in this vulnerable state, and then the immune rebound hypothesis is that the immune system can literally not only swing back to normal, but you've got a baby that's 50% foreign in you that swings too far the other way and becomes over reactive. So you can get a lot of things that are kicked off because of the pregnancy, and Hashimoto's seems to be one of those postpartum [inaudible 00:41:39]. Hashimoto's is an autoimmune disease of the thyroid seem to be conditions that may be very much pregnancy related, but the research is surprisingly sparse.   Tahnee: (41:54) Really?   Dr. Oscar Serrallach: (41:54) Yeah. You think we'd know this really well. Again, we've got the wrong definitions. If you don't go to the endocrinologist or the rheumatologist within the first six months, you are treated like a man or a maiden.   Tahnee: (42:10) Sure.   Dr. Oscar Serrallach: (42:10) They don't even ask you have you had kids.   Tahnee: (42:13) That change hasn't been factored into a diagnosis.   Dr. Oscar Serrallach: (42:17) They're just going, do you have this condition, yes or no? Checklist, blood test, xrays, next and next, rather than looking at the timeline and going, you didn't have this before the pregnancy and you have it after the pregnancy. Sometimes mothers have no idea what's going on until maybe a year or two after the birth of the child. Then it kind of dawns on them that this is not just-   Tahnee: (42:41) Yeah, fatigue.   Dr. Oscar Serrallach: (42:44) Fatigue or sleep deprivation.   Tahnee: (42:44) Yeah.   Dr. Oscar Serrallach: (42:46) So I think I really like this idea of a special field of medicine for mothers that we might call matriarchs or something like that to kind of really show the unique landscape and the unique things that can happen. We've got paediatrics, we've got geriatrics.   Tahnee: (43:05) Yeah.   Dr. Oscar Serrallach: (43:06) I think there's definitely enough research to kind of look at mothers as a separate group.   Tahnee: (43:15) Yeah I seem to remember Chinese medicine, there was ... I can't remember her name now. It might come to me, but there was a textbook translation on sort of gynaecology. They did speak to treating mothers differently and at different stages since the birth as well. Maybe you've come across it. I'll see if I can find it, but I thought it was super interesting because it was sort of the first time I'd been exposed to that idea that you're different and that you might be different 10 years, 20 years.   Tahnee: (43:46) I think from that cellular ... when they talk about the baby's cells, they can stay for a couple of decades sometimes.   Dr. Oscar Serrallach: (43:52) 20-30 years.   Tahnee: (43:53) Yeah, which is like having a foreign cell in your body.   Dr. Oscar Serrallach: (43:58) It can somehow turn the system for good, but then it can also stress the system. This is probably what we're seeing with autoimmune diseases is too many foetal cells come into the mother's circulation and stressing the immune system too much.   Tahnee: (44:11) So would that mean a more, sort of ... I can't remember the word right now, but the barrier of the placenta is more porous.   Dr. Oscar Serrallach: (44:20) Yeah, so leaky placenta. Researchers don't call it that, increased permeability of the placental membrane.   Tahnee: (44:27) Permeability, that's the word.   Dr. Oscar Serrallach: (44:29) It's basically leaky placenta and this idea of preg formation. The placenta is going to be slightly leaky and we've had to revert to a very unique old type of placenta as humans that most apes and most mammals don't use.   Tahnee: (44:43) Yeah, I think you were saying we're one of the only ones ... 20% of something are like us, or not even.   Dr. Oscar Serrallach: (44:48) Well, it's more the fact that it's not the classic mammal, advanced mammal placenta.   Tahnee: (44:56) Okay, it's larger, right?   Dr. Oscar Serrallach: (44:59) It's larger and it has more surface area.   Tahnee: (45:01) Yeah, okay. So it takes up more space.   Dr. Oscar Serrallach: (45:03) So rather than the kind of finger and finger type placenta, which is kind of a 50/50 transaction, it's what they call the mop in the bucket analogy to enable much wider surface area to enable more nutrients-   Tahnee: (45:17) More blood flow.   Dr. Oscar Serrallach: (45:18) ... and essentially fat. So fat's one of the things that-   Tahnee: (45:21) Yeah, in the last stages, a lot of fat.   Dr. Oscar Serrallach: (45:24) Seven grams of fat, which is a major biological back flip that the placenta has to do to enable that. So it means that the placenta is more easily damaged than the placenta of a horse or a pig or something like that, which are pretty stable. So you don't see inflammatory issues in these kinds of animals very often.   Tahnee: (45:45) That makes me think, if a mother comes into pregnancy with leaky gut or something, is there a higher chance of her developing a leaky placenta?   Dr. Oscar Serrallach: (45:54) You would think so, but again zero research.   Tahnee: (45:57) Yeah, this is hypothesis.   Dr. Oscar Serrallach: (45:59) If you've already got too much inflammation, increasing intestinal permeability or leaky gut, even sort of increased brain permeability, sort of leaky brain. Basically conditions of too much inflammation. So if you're having that going into pregnancy, it can work both ways. Sometimes people think it can actually have a massive healing effect with all these hormones.   Tahnee: (46:27) Yeah.   Dr. Oscar Serrallach: (46:28) I've seen that happen. Often I'll try to coach mothers who have had very negative pregnancies or postnatal experiences to then use subsequent pregnancies as a healing experience.   Tahnee: (46:43) Yeah, that's a Chinese medicine concept too, that each pregnancy is an opportunity ...   Dr. Oscar Serrallach: (46:47) Yeah, I love that. I call it harnessing the power of the placenta. The placenta produces hormones to a volume that we can't even imagine.   Tahnee: (46:57) Yeah, it's an amazing organ just in terms of that it's not really either the child or the mother's either. It's this kind of thing.   Dr. Oscar Serrallach: (47:07) Genetically it's the child.   Tahnee: (47:08) It's the child, yeah okay.   Dr. Oscar Serrallach: (47:09) But serving two masters.   Tahnee: (47:11) Yeah.   Dr. Oscar Serrallach: (47:14) It's having to kind of do a trade off sometimes. If it doesn't get it right, one or the other is going to suffer. Then it would be a bad outcome for both.   Tahnee: (47:23) Yeah. So does the child initiate its formation, but the mother provides the nutrition for it, because from what I've understood there's this unusual sharing of resources in that it demands a lot of the mother and the mother will give more than she has if necessary.   Dr. Oscar Serrallach: (47:40) Yeah. So apart from vitamin D, which isn't even a vitamin. It's a-   Tahnee: (47:45) Hormone.   Dr. Oscar Serrallach: (47:45) Pro-hormone, which is kind of a 50/50 sort of share. Everything else is preference for the child, even oxygen. So if a mother were to be drowning or something like that, she would drown first before the child because of fetal ... Haemoglobin will just grab onto the oxygen at the expense of the mother. So, that's how ... Not that it's a very nice example, but it's an example of just how profound that one way street is.   Tahnee: (48:16) Yeah.   Dr. Oscar Serrallach: (48:17) It's true with iron, with DHA, with basically all the vitamins, nutrients, minerals. Daylight robbery is one term I've heard.   Tahnee: (48:25) Yeah, we used to call it a parasite. Kindly, but-   Dr. Oscar Serrallach: (48:30) Yeah. So this is why the focus shouldn't be really on the child. It should be on the mother because, from an animal kingdom point of view, they've got quite a unique set up in terms of we've got this massive brain. People don't realise that we're not like any other animal. 20-25% of our energy goes to feeding our brain, whereas the next animal, which I think is a whale or a gorilla maybe, clocks in at about nine percent.   Tahnee: (49:03) Wow.   Dr. Oscar Serrallach: (49:04) Nature's done a trade off that we have less muscles than other apes. We have shorter digestive tracks and a smaller liver to offset the cost. It's kind of like a budget.   Tahnee: (49:17) Totally. You have this much for the brain, but you've got to lose the liver.   Dr. Oscar Serrallach: (49:20) Then the child is born much earlier because upright walking is more of the pelvis. Instead, we've got this massive head that other primates don't have.   Tahnee: (49:30) Mm-hmm (affirmative). It has to get out before it gets too big to leave the birth canal.   Dr. Oscar Serrallach: (49:33) Yeah. They look at comparative studies are looking at apes. Humans should be born around 22 months.   Tahnee: (49:46) For our perfect health.   Dr. Oscar Serrallach: (49:48) Well, for just how capable that infant is.   Tahnee: (49:52) Yeah.   Dr. Oscar Serrallach: (49:52) You look at other infants that can do stuff.   Tahnee: (49:54) Totally, not just blimps.   Dr. Oscar Serrallach: (49:58) From chimpanzees and gorillas. So from nine months to 22 months, they've got this totally helpless being.   Tahnee: (50:05) Little guy or girl.   Dr. Oscar Serrallach: (50:06) This is why, again, mother nature's had to work out some extra things in terms of more oxytocin to care more about this liability.   Tahnee: (50:17) Sure, and that's where social sort of things came from. I think I've read some anthropolitical stuff that said the reason we've developed societies and cultures and all those villages was because we have these liabilities. It wasn't as easy to move around constantly with helpless babies.   Dr. Oscar Serrallach: (50:35) And we've grown those parts of the brain that enable ... If you look at chimps, they can live in groups of 30. Then enobos, who are much more social, can live in groups of 50.   Tahnee: (50:50) Yeah, ours is like 150.   Dr. Oscar Serrallach: (50:52) 150, and that's because of gossip. No, no, gossip is not a bad thing. You have to keep connection with everyone in your tribe.   Tahnee: (51:01) Mm-hmm (affirmative), so you'll talk about people.   Dr. Oscar Serrallach: (51:04) So you can talk about something you may not have seen for a few days, and that's ... of course it's meant to be a really healthy thing. People checking in, how's so and so down by the river? He's collecting fish from the tribe. How's he or she doing? So gossip is actually part of what enables us to live in those groups of 120 and 150. Then another instalment that we've had is the religious part of the brain that then we can live in super clans. So you can meet someone from a super clan and, if you share a religious ideology, that suddenly goes from 150 to thousands and thousands.   Dr. Oscar Serrallach: (51:41) Research around that is super interesting. The only problem is, when you have a super clan meeting another super clan with different religious ideologies and we don't need to get down to that-   Tahnee: (51:52) We all know what happens.   Dr. Oscar Serrallach: (51:55) Especially if there's resources to be had.   Tahnee: (51:58) Yeah. So one of the things I think, if we just want to start thinking about wrapping up, but the real ... I guess this sense that the mother can be prepared, because this is something I've always seen out of ancestral kind of writings on women. It's like there's this sense of before conception of building the mother's reserves, and then there's obviously the pregnancy, so sort of nutritious and well managed pregnancy. Chinese medicine is very big on that as well. I'm sure most other countries are too.   Tahnee: (52:33) Then this sense of postpartum rebuilding the stores, rebuilding what's been kind of depleted through the pregnancy. That seems to be a really big missing factor in our thinking around pregnancy. I think the nutrition and stuff ... I had a friend who didn't eat anything except for chocolate for her whole pregnancy because she just felt crap the whole time. I'm sure she was okay. The baby is healthy, whatever, but there's this sense that it's not a huge priority a lot of the time for people.   Tahnee: (53:04) So if you're talking nutrition and how to build ... I always think about building healthy blood, building healthy hormones and all these things. What are the main things you emphasise with your clients?   Dr. Oscar Serrallach: (53:15) One thing I've grown to realise in sort of many years of working with mothers is that, behind the hormonal system, behind the immune system and behind a lot of these layers that we kind of see is the nervous system. A key part of maintaining good health and a key part of recovering is around nervous system practises. So these are essentially things that enable us to recalibrate back to a zero point. Knowing that your inflammation, as an example, is immune system out of control.   Dr. Oscar Serrallach: (53:53) Then that drives the immune system, and then that drives the hormonal system, because those are key parts of the brain that decide hormones and the immune response or not are in the brain. When people say it's all in your head, they're being unkind, but they're kind of-   Tahnee: (54:09) Kind of true.   Dr. Oscar Serrallach: (54:09) Yeah, unwittingly telling the truth. So, that's become much more of a theme. The nutrients, the supplements in the food I think all support, but if you're not doing the nervous system practises, then you're losing a lot of the benefit. Of course, the great nervous system practise is called sleep. We know that the average mother loses up to 700 hours of sleep in that first year, so she's already on the back foot.   Tahnee: (54:43) Yeah.   Dr. Oscar Serrallach: (54:43) So how to do you then support her nervous system during the day? Ideally we're doing nervous system practises preconception during pregnancy. I was talking before about 3:00 in the morning, you're baby's not sleeping, you haven't slept for months. That's not the time ideally to start nervous system practises.   Tahnee: (55:06) Mm-hmm (affirmative).   Dr. Oscar Serrallach: (55:10) So I'm really trying to coach a lot of my pre-mothers and pregnant mothers to really start looking into ... What's interesting with nervous system practise is the researchers often say that there is a sense of stillness. There's often paced respiration, so slowed down respiration, slow in breath, slow out breath. There are many things that can potentially tick a nervous system practise, meditation, gratitude practise, yoga, yoga nidra, micro naps, walking meditations, sometimes even craft or creative pursuits.   Dr. Oscar Serrallach: (55:50) Well, if you bring in the breath awareness, you can get into a flow [inaudible 00:55:53] that can really help recalibrate the nervous system. Just realising that can do way more than what a lot of supplements can do.   Tahnee: (56:02) Yeah.   Dr. Oscar Serrallach: (56:03) So we shouldn't just be focusing on that without really giving importance to those nervous system practise. Then re enabling mothers to do these things, because when you're 24/7 busy, the universe is never going to come along and say, hey mom, do you want to-   Tahnee: (56:21) Take off an hour.   Dr. Oscar Serrallach: (56:22) Yeah, a 30 minute guided meditation. No one will disturb you. That's just not going to happen.   Tahnee: (56:25) Okay.   Dr. Oscar Serrallach: (56:28) So ideally the concept's already there. The practise is already there. Then that inner circle, that team, the guardians-   Tahnee: (56:37) Facilitating.   Dr. Oscar Serrallach: (56:38) Facilitating and honouring. It takes more than a tantrum for one of your kids to come knock that off your schedule. Whereas I see so many mothers just going, today was a weird day, I didn't do my practise. It's like, well when did you last do your practise? Two weeks ago. It's like, we really need to empower mothers to ... Something I've recently started comparing these nervous system practises to is like brushing your teeth. Dental health practise, you do it twice a day. You don't really think about it too much. It feels odd if we don't do it and we're looking for a longterm dental health. Teeth don't fall out tomorrow if you haven't brushed your teeth, but we'll kind of go out of our way. If we're out camping and we don't have a toothbrush, we'll sort it out pretty quickly usually.   Tahnee: (57:36) Yeah.   Dr. Oscar Serrallach: (57:38) So we kind of need a mental health practise, [inaudible 00:57:41] we don't have to really think about it too much and it feels a bit strange if we don't.   Tahnee: (57:45) Yep.   Dr. Oscar Serrallach: (57:46) So what I really encourage mothers to do is what does that look like to you. Then what have you done in the past that might fit that. What are you thinking about that might fit that. Then you here a few suggestions. Then once you're doing those practises, guard them.   Tahnee: (58:04) Yeah, with your life.   Dr. Oscar Serrallach: (58:05) Well, as if your life depends on it because, ironically, it does.   Tahnee: (58:10) It does, yeah. You mentioned yoga nidra, and it's funny because I haven't had the experience of not ... I'm a yoga teacher and I had a practise since I was 15 at various degrees of commitment as I was in my 20s and stuff. But from my mid 20s to now, I've been very committed, and I can find myself, if I put on a major recording, it's the equivalent of a good nap for me or something like that. 20, 30 minutes can revitalise me.   Dr. Oscar Serrallach: (58:43) Yeah.   Tahnee: (58:44) If I feel myself coming down with something, I can do a yoga nidra and it seems to ... What you're saying about it actually turning off the kind of stress response and the information makes some sense. It always puts me in that heal response.   Dr. Oscar Serrallach: (58:57) It's a recalibration.   Tahnee: (58:59) Yeah. I don't get sick a lot of the time if I'm consistent with it. But it is something that ... I can imagine if it's not something in your repertoire, it can feel a little bit confronting to go and find. Do you have any resources or places, people that you recommend to your mums?   Dr. Oscar Serrallach: (59:19) Well, I first kind of acknowledge the situation. I explore what mothers have done in the past. It's kind of maybe that we have to reinvent the wheel. Yoga nidra is very easy to find. Many things on the web now, so I'm not kind of attached to any particular style. Essentially it's a guided meditation with body awareness and breath awareness.   Tahnee: (59:43) So anything along those lines is going to be of service.   Dr. Oscar Serrallach: (59:47) Even micro napping where you technically you don't go to sleep. You touch a sleep space.   Tahnee: (59:51) Like a liminal or half awake naps? Is that what you mean?   Dr. Oscar Serrallach: (59:55) Yeah, for 15 or 20 minutes.   Tahnee: (59:56) Yeah.   Dr. Oscar Serrallach: (59:56) You literally touch the sleep space. You may need to put an alarm on. The guided meditation is kind of your alarm in some way because it-   Tahnee: (01:00:02) Sure. It tells you to come up again.   Dr. Oscar Serrallach: (01:00:05) Yeah. You can get a good four hours after that. Even place like Google and all of these large corporations.   Tahnee: (01:00:13) Yeah, we do it here. It's only twice a week. The guys have a half hour meditation session.   Dr. Oscar Serrallach: (01:00:22) Okay. Probably wht Google have sleep pods where they kind of expect people to have a micro nap, not because they care about their employee, but-   Tahnee: (01:00:27) Better productivity   Dr. Oscar Serrallach: (01:00:28) Well, then the product of your research. Your product nosedives after six hours. It doesn't matter who you are.   Tahnee: (01:00:35) Yeah.   Dr. Oscar Serrallach: (01:00:36) If you're a mother, if you're working, if you've had six hours you're toast. You need something rejuvenating and something that's relatively easy. I often talk to my mothers about cue points, and a cue point is where you are cued to do a relaxation of some sort. So a cue point might be on the toilet. It's usually a place where you're physically still. It doesn't always have to be. So at traffic lights. Literally in a cue at the super market, those kinds of things.   Tahnee: (01:01:04) Cue, cue.   Dr. Oscar Serrallach: (01:01:06) That's just an invitation to do maybe five slow in breaths and five slow out breaths. It's really amazing when you become more practised at these things. You think oh my gosh, I kind of just felt a bit frazzled before, but I'm a little bit more centred now, a little bit more resilient. That can make all the difference. If you're doing that enough times and then you're doing some bigger practises once a week and looking at your nutrition and your purpose, and being active enough but not over-exercising, and eating the right food for your body type at the right kind of stage.   Dr. Oscar Serrallach: (01:01:44) Motherhood, that nervous system intervention can make all the difference. Then it can actually improve the quality of your sleep. There's so many ... I talk about a virtuous cycle. This is a vicious cycle. A vicious cycle is I haven't slept well, I'm so tired, my cortisol is low, my blood sugar is not great, I'm just eating on the run. I'm not making the best decisions, I'm frustrated, I'm getting angry and then I'm feeling bad about myself because of the anger. That's a real vicious cycle. Then I'm being combative with my partner. We're not having that kind of connection time. Then dominoes for that can be just a constant state.   Tahnee: (01:02:28) Totally.   Dr. Oscar Serrallach: (01:02:29) A vicious cycle. Whereas a virtuous cycle is you do something that makes it a little bit easier to then maybe do some ... make a better food choice or make sure you protect that space for your nervous system practise that makes it easier for a healthy interaction with your partner, that makes it easy to then advocate for yourself. It makes it then easier to kind of see what's kind of going on, realise okay I actually need to kind of change a little bit.   Tahnee: (01:02:53) Totally, react to your kids.   Dr. Oscar Serrallach: (01:02:55) Yeah, you just go, okay this isn't working, and have the energy and insight to kind of change in a healthy kind of way. Whereas, if you're just in postpartum rage or anger, while that energy is there to motivate change, the change is often not whether you want is what you're really desiring.   Tahnee: (01:03:13) Yeah.   Dr. Oscar Serrallach: (01:03:16) It fuels ... So again, it's not about perfection. It's just about slightly better.   Tahnee: (01:03:21) Yeah.   Dr. Oscar Serrallach: (01:03:21) Then slightly better leads to slightly better. That's what a virtuous cycle is.   Tahnee: (01:03:25) Mm-hmm (affirmative). Instead of those little steps in a downward spiral, it's little steps in an upward spiral.   Dr. Oscar Serrallach: (01:03:31) Yeah. Sort of week to week, month to month. I often see mothers going, I'm still tired but I'm doing so much more and I feel better in myself, and I'm a bit clearer. The other thing is that I've stopped asking mothers how are you feeling because probably a better question is how much are you doing.   Tahnee: (01:03:52) Mm-hmm (affirmative).   Dr. Oscar Serrallach: (01:03:53) In

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.16.384958v1?rss=1 Authors: Blosser, M. C., So, J., Madani, M. S., Malmstadt, N. Abstract: Determining the permeability of lipid membranes to gases is important for understanding the biological mechanisms of gas transport. Experiments on model membranes have been used to determine the permeability of lipid bilayers in the absence of proteins. Previous measurements have used a number of different methods and obtained widely varying results. We have developed a microfluidic based microscopy assay that measures the rate of CO2 permeation in Giant Unilamellar Vesicles (GUVs), and we report permeability data for the POPC-cholesterol system. We find that cholesterol has a strong effect on permeability; bilayers containing high levels of cholesterol are an order of magnitude less permeable than bilayers without cholesterol, 9.9 {+/-} 1.0 x 10-4 cm/s vs. 9.6 {+/-} 1.4 x 10-3 cm/s. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.19.345579v1?rss=1 Authors: Hjukse, J. B., Vindedal, G. F., Sprengel, R., Jensen, V., Nagelhus, E. A., Tang, W. Abstract: Astrocytes are intricately involved in the activity of neural circuits, however, their basic physiology of interacting with neurons remains controversial. Using dual-indicator two-photon imaging of neurons and astrocytes during stimulations of hippocampal CA3 - CA1 Schaffer collateral (Scc) excitatory synapses, we report that under physiological conditions, the increased glutamate released from the higher frequency stimulation of neurons can accelerate local astrocytic Ca2+ levels. As consequences of extracellular glutamate clearance and maintaining of astrocytic intracellular Na+ homeostasis, the increase of astrocytic membrane Ca2+ permeability via Na+/Ca2+ exchanger (NCX) reverse mode is the primary reason of eliciting astrocytic intracellular Ca2+ elevation upon neuronal stimulation. This Ca2+-induced Ca2+ release is dependent on inositol triphosphate receptor type 2 (IP3R2). In addition, ATP released from Scc excitatory synapses can contribute to this molecular mechanism of Ca2+-induced Ca2+ release in astrocytes. Copy rights belong to original authors. Visit the link for more info

Interview with Neil Young, MD & CEO of Elixir Energy (ASX:EXR)

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.14.339291v1?rss=1 Authors: Massaccesi, C., Groessing, A., Rosenberger, L. A., Hartmann, H., Candini, M., di Pellegrino, G., Frassinetti, F., Silani, G. Abstract: Interpersonal space can be defined as a safety zone immediately surrounding our body, which allows us to feel comfortable during social interactions. Previous studies indicate that the size of interpersonal space at which the other is perceived as intrusive (permeability) and the ability to adapt interpersonal distance based on contextual factors (flexibility) are altered in children and adults with Autism Spectrum Disorder (ASD). The present fMRI study aimed at extending the previous findings by investigating the behavioral and neurophysiological underpinnings of interpersonal space permeability and flexibility in adults with ASD. Individuals with ASD and matched controls (CTR) performed a modified version of the stop-distance paradigm for measuring interpersonal space preferences. Participants observed prerecorded videos of two confederates moving towards them and rated their comfort to the observed distance. The assessment of interpersonal space preferences was performed before and after engaging in cooperative and non-cooperative social interactions with the confederates, experimentally induced by means of a repeated trust game. We observed general lower comfort in response to an approaching confederate in the ASD group compared to the CTR group, indicating preference for larger interpersonal space in autism (altered permeability). This preference was accompanied by reduced activity in bilateral dorsal intraparietal sulcus (dIPS) and left fusiform face area (FFA), regions previously shown to be involved in interpersonal space regulation. Furthermore, we observed differences in effective connectivity among dIPS, FFA, and amygdala in ASDs compared to CTRs, depending on the level of experienced comfort. No differences between ASDs and CTRs were observed in the adaptation of interpersonal space following a cooperative and non-cooperative social interaction, suggesting preserved interpersonal space flexibility in the ASD adult population. The present study provides evidence for impaired permeability of interpersonal space in adults with ASD. The findings suggest that a dysregulation of the activity and connectivity of brain areas involved in the processing of interpersonal space may contribute to preference for larger distance and avoidance of physical proximity in ASDs. Future research is needed to examine whether the observed alteration of interpersonal space processing is an effect of or a contributing factor to the social disabilities characterizing autism. Copy rights belong to original authors. Visit the link for more info

Light cannot be anything but a longitudinal disturbance of the AETHER. Light can be nothing else but a sound in the AETHER. Like a vocal frequency propagation. Not through the medium, OF AND WITHIN THE MEDIUM!

Light cannot be anything but a longitudinal disturbance of the AETHER. Light can be nothing else but a sound in the AETHER. Like a vocal frequency propagation. Not through the medium, OF AND WITHIN THE MEDIUM!

Democracy is a constant work in progress, in need of special attention during moments of crisis. The pandemic has seen some states coordinate efforts with careful attention to individual rights, while others have taken advantage of the centralization of power for other ends. How permeable are democracies in times of crisis? How are democratic practices and institutions being tested? Which countries will emerge more resilient and which will struggle? The Recovery Project is pleased to be joined by the Honourable Stéphane Dion, Canada's Ambassador to Germany and Canada's Special Envoy to the European Union and Europe

Trauma Recovery and Ketosis, Homebirthing, Coffee and Gut Permeability, Paleo to Agricultural Revolution Protein Timing, Eating For Your Genes (GenoPalate) Make your health an act of rebellion and join the community here. Please Subscribe and Review: Apple Podcasts | RSS This episode of The Healthy Rebellion Radio is sponsored by Athletic Greens. Whether you’re taking steps towards a healthier lifestyle or you’re an athlete pushing for better performance, Athletic Greens gives you the nutrients you need for your body to thrive. Jump over to athleticgreens.com/wolf and claim my special offer today - receive 20 FREE Travel Packs with your first purchase (value $79). These travel packs make it easier to cover your nutritional bases while you’re on the road. Go check it out at athleticgreens.com/wolf and claim your special offer. Submit your questions for the podcast here   Show Notes: Our book Sacred Cow is now officially available for pre-order.  The publisher is nervous about the Covid climate, with bookstores being closed, etc. They are being excessively cautious with the print run during this time, so please go ahead and pre-order now.  ---- News topic du jour: Methane: Accounting for both sides of the scale 1. Trauma recovery and ketosis [18:47] Lorena says: Hi Robb & Nicki! I've been following you for a few years an have FINALLY started the Keto Masterclass! Thanks for offering it during this global pandemic season. This is way more practical for me to dive into vs AIP at this time. I'm a psychotherapist specializing in trauma and am a student of Somatic Experiencing, a modality that draws on the body's innate ability to process and recover from traumatic experiences if we give it the time, space, and attention (super short synopsis). We focus a lot on incomplete fight/flight responses that keep us in cycles of trauma and thus high activation (muscle tension, gut issues, pain, and a LOT of other somatic symptoms). I'm going through module 2 where you explain the purpose of ketones and you say that this frees up the glycogen to "only be used when we need it." This makes me wonder if/how the over-consumption of carbs and thus always burning those carbs can perpetuate this sympathetic nervous system response keeping trauma survivors from being able to regulate themselves. I'll leave that there to hear how you would parse through that information and your wide ranging knowledge and will reach out with follow up if need be. I'm thinking this could be a very useful thing for me and my colleagues to consider, especially as we as a society come to grips with nutrition having MAJOR effects on our mood and mood regulation. I look forward to hearing your thoughts on this! Lorena Austin, TX :)   2. Homebirthing [25:39] Megan says: I’m pregnant with my first child and have been doing a lot of research on natural/home-birthing.  It makes so much sense to me to give birth this way and yet it seems so many people, including my closest friends and family, are resistant to the idea.  It would be super helpful to hear your perspective and how you decided to do it.  What factors did you consider?  Would you be willing to share your experience of having a home birth, and would you recommend it?   Megan, Boise, ID   3. Coffee and Gut Permeability [39:17] Laurel says: Hey Robb, Though I am sure you have seen this...in the light of it's take on coffee lowering iron, and not sure if the research mentions its relationship with gut permeability or not - haven't read the whole thing yet. As I don't hold back on coffee, and don't hear you saying you have seen any hard evidence to do so, I wondered what your thoughts were on the research linked below? Could be its only a negative if you are fighting this type of disease?? cheers, btw, love love love your and Nicki's show. https://www.researchgate.net/publication/337832528_38-month_long_progression-free_and_symptom-free_survival_of_a_patient_with_recurrent_glioblastoma_multiforme_A_case_report_of_the_Paleolithic_Ketogenic_Diet_PKD_used_as_a_stand-alone_treatment_after_f Note: https://www.cyrexlabs.com/   4. Paleo to agricultural revolution protein timing? [43:06] Max says: Hey Robb.  Our paths had crossed a  bit in the CrossFit hey days via Brian MacKenzie and CFE as I was an endurance athlete and coach for CFE for about 6 years.  Anyway, it was a long time ago but your teachings/guidance and books have been a boon of information and transformative in my understanding of nutrition. Anyway, I've been ruminating over a few things lately about paleo and wired to eat and all the circumstances around the various points of view and something occurred to me.  Up until about 5-10,000 years ago, all humans (in a 4 season climate) would have been only born in the Spring just like most large mammals.  Obviously life born into the early Spring and even into the late summer may provide exceptions, but for the most part, this 3-5 month time of the year would have provided the statistically safest time frame for survival after birth.  Taking this into account, then it is safe to say that only neanderthals/homo sapiens with large winter food stores (pre agricultural revolution, this would only mean moose, caribou, seals or the like in large protein resources) could actually provide enough food to sustain life in such cold winters.  Hence, perhaps these large gluts of protein intake in younger years is what would have built up such strong bone/muscle as seen in paleo man? Fast forward to all the skeletons and/or life like art images of the middle ages and most humans are almost a foot shorter and much smaller than paleo man most likely due to the lack of protein at these earlier ages in life as the agricultural revolution had provided an ability to harvest and store grain during harsh winters rather than only being able to find protein/fat in large animals. This same 'glut of protein' concept can be drawn into today and explain how humans are so much larger (think Lamar Jackson/Lebron James) and obviously fatter.  Spun forward into "OK, so who cares?", perhaps the timing of a strong protein access source (seasonal "gluts" from ages 2-12?) is also a possible prescription?  I know this falls into a very convenient "eat locally with the seasons" paleo based protocol, but I just can't get my head away from asking 'If essentially all humans were born in the spring (at some point) and then only had mother's milk and protein to eat at such an age until the following Spring, what are key observations about what this can tell us from a seasonal, age based macronutrient perspective?' Anyway, sorry to fill up your inbox, but wanted to thank you again for all your hard work and through this POV out. How the Mid-Victorians Worked, Ate and Died: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672390/ 5. Eating For Your Genes (GenoPalate) [49:26] Mike says: So my question is about the gene testing for diet. I recently had the 23andMe do and sent that data to GenoPalate. Just wanted to know what you guys think about the idea of eating for your genes and these results  overall. I’ll include some screenshots. https://imgur.com/a/8E9bAMu   Transcript: Download a copy of the transcript here (PDF)

Autoimmune disease often starts in the gut. In fact, intestinal permeability is believed to be a necessary precursor to autoimmune disease. In this interview with Dr. Drew Sinatra, a naturopath from Northern California and co-host of the podcast “Be Healthistic”, we talk about what the research says about the gut microbiome in autoimmune disease, his approach to treating autoimmunity and immune-supportive supplements, as well as his approach to treating Epstein-Barr virus, SIBO, candida and much more. Lindsey Parsons, your host, helps clients solve gut issues, reverse autoimmune disease and type 2 diabetes naturally and lose weight without cutting calories or cutting out major food groups. She's a Certified Health Coach at High Desert Health in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on Facebook, Twitter, Instagram or Pinterest or reach her via email at lindsey@highdeserthealthcoaching.com to set up a free 1-hour Healthy and Sustainable Weight Loss/Health Restoration Breakthrough Session. Show Notes

All right, gut check fans and everybody at KBMD health. Thank you all for joining us again for a third installment of the COVID file. Dr. Brown and I are here to talk a little bit about the physiology and kind of how people actually get sick. And Dr. Brown actually asked me to do a little role reversal. So can you want to explain a little bit what's going on here?Yeah, so this is COVID files number three, and we got a lot of feedback when Dr. Ackerman and I did 2.5 we're all we did is talk about the gastrointestinal stuff. Then everybody else is in the news is talking about respiration, pulmonary stuff. And so we got a lot of questions about that. And I just happen to see that like, a world renowned infectious disease doctor, Dr. Peter Hotez was on Joe Rogan. And Joe was asking all these lung questions in detail, so I realized that you know, you're an expert in this your training is a crna. This is right in your wheelhouse. So I thought that we could just do some of that. Even on some of these other shows, they're interviewing virality and they're interviewing epidemiologists and they go really, really into the science. What we know that calm is contagious. And we know that the more information you have that can actually calm you down. And that's what we're trying to do in this show. We're trying to get people through this crisis. But I do believe that if you understand the physiology, then it makes sense why some people can get really sick and it makes sense why some people get better. And so you being an expert in this is just perfect. And we're getting questions like this like from a Mike Logzen from Texas. Interesting. We have one of those working for us also. Yeah I know, names like that. Just keep popping up there's Mike Logzen one, Mike Logzen two I wonder if there's a Mike Logzen three.I know, so Mr. Mike Logzen and asked what are your thoughts on why younger people and healthcare workers are getting hit hard as this disease goes on? That's a great question. And in fact very relevant. Newsweek just did an online publication that I received this morning, where it said the over 100 healthcare workers have died from COVID-19 So this is this is an important question. So really what we're going to do with you today is talk about the pulmonary physiology and what happens and when people say, oh, this can affect you, and you get this rapid progression that can be very frightening and different things like that. But just understanding what's going on, I think is the real important thing. So, I just want you to take it away. I'll interrupt. I'm hopefully not too much, because I have a tendency to do that. And if I am just gonna wait I got a slide on that. We'll get to that. SoA couple a couple of quick apologies that we learned in technology since we are all practicing social distancing and Dr. Brown or Ken is, is addressing his patients over in the Plano area I'm trying to help out over here in the in the Denton area. We actually are not together obviously, it's while we're recording like this, so I had to make some really bad drawing slides. Ken, you're gonna love these they are they're really, really artistic. And as I share them with you gonna pull our faces down from the screen. So bear with us, it's not normal. But we'll try to take some breaks in there, we've learned we can't put them all up at the same time at least we're not smart enough to do that. And Ken if I go too deep, if you feel like I'm losing votes just going back, hang with us though. The goal here is to show you how the disease itself is probably going to affect your lungs. And then to get to a point of showing you how we think we can work through it. I'm going to show you the tough parts, but at the same time, what it is that we're hoping to do to really get people through it. So that'sReally even if this is not relevant to you, I I do know where we're going to go with this. And right now, the mayor of New York City is thinking about bringing in a doctor draft where basically they're going to pull doctors out of retirement, they're going to ask doctors in different specialties to try and help out with these pulmonary issues. So you can even forward this to your doctor if you have family or friends that are in the healthcare field. This is something you could forward to them. Because if I happen to get called in, I want to be informed on how to treat people with their pulmonary situation, not just their gastrointestinal. So this this could also be very relevant for healthcare workers, our frontline people.I agree, I agree. And I'm hoping that we can make some make some light of not necessarily light but bring some information that gives some people some comfort. So you'll see here my very first drawing right off the bat did not load the way I wanted it to. So that's a little bit of humor there. And that's about as good as these drawings are going to get. So I'm sorry, these are loans. That little green arrow is pointing up to a diaphragm, just a quick refresher, as a diaphragm contracts, it pulls down on the lungs, giving a negative pressure or pulling air into the lungs. And that's important when you're healthy. You're pulling air in, you're not necessarily having it pushed in some but what you need to recognize is that the lungs are made up of five different lobes the left lobe has two the right lobe has three and every single one of those lobes has tons, literally over 300 million alveoli per lung. So you a 70 kilogram average adult has around 600 million alveoli and that gives you tremendous surface area for oxygen and co2 exchange. That's what keeps us alive and that's what the oxygen keeps us alive in the co2, of course, is our waste gas that our body is pushing out. And if you were to spread it out flat, that equals to roughly a little bit larger than a tennis court, so Ken.Wow, and so the analogy I always thought about this is a tree the main bronchus is the trunk, then you get split, and then it keeps going into smaller branches where the leaves could kind of represent the gas exchange or the alveoli. Do you visualize it like that?Yeah, tree is exactly what they call it. It's a tracheobronchial tree and it runs all the way out. There's actually I believe, 23 generationss of tubes getting smaller and smaller and smaller until we get out to the alveolus itself. So alveoli is all of them. Alveolus is a singular one, don't hold me to it, I often interchange them myself while talking about them. So one particular alveolus. I've just drawn an arrow, it's in the lungs, it's everywhere. But I'm making an arrow and a draw here, because this is what we're really going to get started with on how it all functional I'm sorry, here's the heart. We'll we'll talk about this a little bit later in positioning but know that the heart lies anterior towards the front of your body a little bit, and a little bit over to the left. So but that's where the heart is located as it receives blood pushes it to the lungs receives the blood again and then pushes it out to your body. So let's look at that alveolus. The alveolus right here, you'll see inside the circle, that's actually the external air that we've just breathed in. So that's where our fresh air oxygen, oxygen rich air will come to, and it will be taken up by the capillary. The capillary is the blood supply that's bringing up the gas that needs to pick up oxygen and let go of excessive co2 carbon dioxide, that's the waste gas.So that's the exchange, the oxygen goes in carbon dioxide goes into the little alveoli, then we breathe that out.That's exactly right. And you'll notice, even though my drawings are poor, you'll notice you'll see the capillary here in a moment is going to start to kind of pull away in distance and that just makes it harder for that gas exchange. Inside the alveolus there are two specific cells that we have in there pneumocytes. So site means cells, pneumocyte one offer gas exchange pneumocyte two are there for surfactant, they make surfactant. Now, granted, the there are more pneumocyte twos than there are pneumocyte ones, but the pneumocyte ones actually take up far more real estate for gas exchange but the pneumocyte twos make that very important surfactant which allows the alveoli to expand without collapsing. And that becomes a problem for us as we as we move along. What we've returned to you here in this particular drawing, I've only drawn a pneumocyte two because that's where the infection occurs with the current virus that we're addressing the coronavirus.We'll just say Remember, a lot of people were talking about the ACE two receptor, this is what they're talking about on the news, the these type two pneumocytes have a lot of these h2 receptors. So that's the target. That's correct. I didn't throw that on there. But that's, that's a definite point. H2 receptors are located right there on that type two pneumocyte. The little blue dot at the top is going to represent a Coronavirus. And it's going to attach to this type two pneumocyte. So next what happens we're just going to be reminded here that surfactant is important. It breaks the surface tension. Without it, the alveolus will collapse. Very important. I'm going to remind you a few times about that. So now, the little blue dots inside of the type two pneumocytes represent the replication or basically the the increasing number of viruses that have just now been transcripted. They're they're multiplying, and now it's infected the cell.So just to go back to our very first COVID episode, the virus gets into the cell hijacks, it gets the cell to produce more of the virus. That's why they're growing inside the cell itself.They definitely are. And then this is not what the cell is programmed to do. So unfortunately, the cell is going to rupture and die, and the virus is going to escape to the alveolus. Now I'm going to stop real quick and remind everyone. Remember, I said that there are type two pneumocytes actually out number the type one. So the problem is it's not just one type two pneumocyte in this particular alveolus is is infected, probably most, if not all of them in this alveolus certain thing. And so this is happening all over this alveolus. Well, not only is new virus going to escape. These little red dots I just added in there represent inflammatory mediators, and they carry a message. They are searching for help. And not only that we now have a ruptured and dying and dead cell. So you'll notice I've drawn in here, Ken, what would be inside an alveolus like this? What are these things called? You remember?Yeah, I believe you're going to talk about macrophages now.Yeah, macrophages. Exactly. They are the janitors of the immune system. And he's there to just generally clean up regular debris and cellular debris and then take it in and then basically, it usually gets ushered out or absorbed by left, etc. But what we have now is a crisis situation because it's not just happening at this time to new massage. It's happening probably to most of them. They all begin to be picked up these inflammatory mediators are picked up by the  macrophage itself, and that's going to activate it. It now knows it needs to release some messengers of its own to call for help. And right here is the beginning of something they've been talking a lot about in the news, especially for young people. And that's the cytokine storm. Because these interleukin one, interleukin six, and tumor necrotic, factor alpha are all cytokines. And they are going to be released and picked up by the blood supply the capillary right down here, and they are going to have some immediate local action. And as this is happening, remember I said there are up to 600 million alveoli throughout the throughout your lungs is this begins to happen in this section. Imagine all of the interleukin one, six and TNF alpha that will be picked up by the blood supply and now begin to spread throughout the body. So you can see now they've made their way into the capillary bed, and a few things are going to happen right off the bat. Once they first enter the capillary bed. The capillary itself is going to dilate. That's going to lower the blood pressure, but it's going to increase the blood flow. This happens with injury all over the body we we have an injury, you have swelling, it's very, very normal because you're bringing in other things to help repair. But when this happens over and over again kind of an uncontrollable situation like we're going to talk about, that's why we know that we need to manage this particular situation. The permeability of the capillary itself is going to increase that's going to allow for some fluid to escape the capillary bed, and then begin to infiltrate the alveolus itself. So fluid, also known as blood plasma escapes to the interstitial space, which is the space between the capillary and tissues, and then also goes into the alveolus. So, the permeability or now we've got a leaky capillary bed. Permeability is not necessarily something that is in response to it it is because the capillary basal dilation is stretching it too much, are you aware of how the leaky capillary happens?In a, in a really microbiology term, I think what happens is that those cytokine, if I'm recalling correctly, the cytokine mediators activate endothelial cells, which are the cells inside of the capillary. It actually caused them individually to constrict which makes holes. So if you can think of two large men and suddenly they become skinny men without moving their feet, there's now space between them. Does that make sense?Yes.That's kind of that's kind of how I remember it anyway. But that allows the blood plasma which is normally contained in the capillary bed to then escape go into the interstitial space migrates into the alveolus. And this is not what we want. I'm going to reiterate that surfactant is important. It breaks the surface tension of liquid. Without it, the alveolus will collapse. Well, we just had those type two pneumocytes that were producing surfactant. But now they are beginning to be damaged and not produced surfactant at all. And when they were producing it, they were producing the correct ratio, which meant that for the fluid that was there, remember, when we breathe in it's 100% humidity in the alveoli. Once we don't have surfactant, now we don't have enough in the ratio to help keep it open. So losing cells that produce surfactant, and then we dilute the existing surfactant that is going to increase our surface tension. And the potential of collapse of the alveolus is inevitable.So the surfactant the way I've always kind of thought about it when you don't have surfactant, the alveolus they will stick to each other they cannot slide and open up and so it becomes a very in the dumbed down terms like it like a stuck balloon that's that can't expand.That's correct. Now written consolidation up here, it may be a little premature at this point. But we will return to it. This is the method of how consolidation occurs. Like I said, forgive me for my drawings, I just did these and snapped them and loaded in the computer. I knew, I knew I couldn't draw and talk at the same time very well. But regardless, you'll see that fluid's beginning to build up. Little red dots in there represent cellular debris. Also, some virus is still trapped in there. Some proteins which are broken ours are still stuck in there. But remember, I warned you earlier, the capillary beds beginning to pull away, right, the interstitial space is also continuing to fill up along with the alveolus. That pressure outside the alveolus and in the water on the inside of the fluid on the inside, will basically make this alveolus you have the potential to collapse it will not expand nor contract with each breath. It basically just kind of floats as a membrane would between two liquids. I've also drawn oxygen up here at the top and co2 still in the capillary bed. The sheer distance for the diffusion is going to render This alveolus is incapable of gas exchange. That's that...So in this picture, just to clarify the oxygen that you breathe in hits this fluid, because the alveoli is filling up, and it's not getting to the other side where it needs to go.That's correct. It cannot just really won't diffuse that even though macroscopically may look like a short distance. It's it's still far too far for efficient gas exchange for oxygen and co2. So remember, this is what it should look like the oxygen will come in you right next to the alveolus to the capillary co2 goes, goes out O2 comes in. No big deal. That's just not what's happening right now. The next step that happens and takes us to full consolidation is going to be the summoning of these neutrophils another part of our immune system, they normally would come in, and in a healthy IV alveolus would more or less be able to target viruses and other pathogens that could be found within the lung. But in this particular situation, especially with the amount of fluids taken on, they actually become a little bit indiscriminate. And they use two agents primarily: the reactive oxygenation species and various proteases. And instead of a targeted attack, with the dilution here, inside the alveolus it actually just becomes kind of a, a wide away, wide array spray of attack. And not only do they grab ahold of some of the proteins that don't belong there and some of the cellular debris that needs to go. They'll also end up attacking indiscriminately against healthy lung tissue, healthy pneumocyte ones and pneumocyte twos. So when people talk about a bacterial pneumonia, this is the beginning of having a super infection in addition to the damage that the virus has already caused.It is it is and again, Brown and I are not telling you any of this stuff so that you become panicked. But really it's the opposite. knowing what's happening may help you understand number one, what it is that your health care provider needs to do to keep you and your family safe if you happen to find yourself in this situation. And number two, I think here in a moment, as we wrap up some of this, this discussion, you'll see maybe some things you could do at home to outrun some of this.Yeah. So what we're doing, what you're doing is you're setting the stage work that you if you understand the physiology and the pathophysiology, then you can start doing some modifications to try and improve. And that's where we're headed here.Definitely. And again, this is called consolidation at this point. This just basically establishes it's just a word that says that this side has been consolidated, it's not functioning, air will not be exchanged here, we will not have oxygen pick up nor co2 blown out by this alveolus. Now you kind of have to picture not just this alveolus but the entire portion of the affected lung is now experiencing a portion of consolidation. So let's talk about what's happened so far. We've lost type one and type two pneumocytes: one is how we breathe or the gas exchange two makes the surfactant to keep the alveoli open. Our gas exchange, of course is going down. Our surface area, our tennis court size of surface area for us to pick up oxygen is being decreased. And our diffusion distance at the alveolar level is increasing, even for those that haven't been consolidated, right. So we have a decrease in gas exchange. You'll see this little abbreviation I've debated on whether or not to put it up there, they'll PaO2. That simply just represents the pressure of oxygen in the artery. Big P means pressure little a means artery. O2. So that's just a cool shorthand that medical workers use to identify the partial pressure of the oxygen in a particular location. Inevitably, it just means that we have low oxygen and that gives us a word called hypoxemia.Low oxygen.Yeah, low oxygen. Can you just on that note right there because we use pulse oximeters all the time, and even get them at Walgreens, can you explain the difference between the number on the pulse oximeter and the PaO2?That's a, that's a great thing. So on a pulse oximeter that really is only reading the percentage of the red blood cells that are fully saturated. So there are actually four binding sites on a normal red blood cell for an oxygen molecule to bind on to an iron molecule. If all four of the sites are occupied before the red blood cell has delivered it to a tissue, and it will be counted as one that's saturated. So if you have 98% saturation, that means 98% of your red blood cells have all four sites occupied before they deposit one. This is a little bit different. This is actually the carrying capacity of, of the red blood cells and how much of the oxygen is actually present to make a difference. So SPO2 talks about how well the red blood cells are actually picking up the oxygen to take it somewhere. But let's talk a little bit about this. Ken you said that your son went to play in in I believe was in Mexico?Yeah it was Mexico, very high altitude. He was there for four weeks, I think. Yeah, very high altitude. So essentially it was high altitude training in several tournaments.We can use that kind of an example, when he was up there, do you think for one second that his oxygen saturation was ever at risk? Probably not. No. He was saturating them just fine. But what he didn't have was a high enough oxygen pressure. So his body sensed that sensed the decrease in oxygen pressure and begin to produce more mature red blood cells to become more of the bus carriers to pick up more oxygen and take it out. So we probably remained at 99% saturation the entire time, but he actually just needed more oxygen molecules themselves to sustain it because there's just less atmospheric pressure at 7,000 feet.Yeah, and that's what we had to come to that conclusion because when it came back, we he got to work up by his pediatrician. And we were all a little bit alarmed to see that his hemoglobin and hematocrit had jumped way up. And it was in response to being in high altitude. So it was the body's adaption to it.Well, that's I completely agree with that. And that's actually you guys, that's actually a normal thing to have happen. You have a higher red blood cell count at a higher altitude.So now you're going to talk about the thing that's, that's the hard part, which is the work of breathing goes up.It definitely definitely work of breathing goes up fighting this tougher distance of diffusion losing a portion of your lung capacity to move gas is going to increase the work of breathing and then throughout this theme Ken, you're going to see the word work pop up because it works in the complete opposite direction of what's happening in the lungs for someone to more or less recover on their own. So cough is going to set in if it hasn't already, that's going to increase the work of breathing. And don't forget these viruses are pretty smart. That's actually going to help spread the virus. So that's a, that's no good either. Work by the body requires more oxygen again, that's why I'm going to highlight that and just kind of think about that for a moment. If I'm decreasing my availability to get oxygen, but the work and the demand is going up. I've got an intersection of a problem here. And if not recognized soon enough, it could just get worse. So let's talk about why the why hurting your lung and recovering from an injury is probably more important than just hurting your ankle now. This is Mike Logzen's number three. This is his ankle.Yeah, he sent us a picture. He said you can use my ankle as an example. Thank you. Yes. So Mike number three thank you for sending in this photo. And Mike is into jujitsu and he showed me after one of his injuries that he has that ankle twisted, and he said ouch. But the good thing about hurting your ankle, okay? You do get edema just like what we're having up here, the fluid buildup in the lungs, you could get edema have a swollen ankle. But the good thing is I don't have to breathe through my ankle, there is no mouth there, I'm not going to have to draw any air at my ankles, so I can just lay up and rest. The problem with having adema or fluid buildup in the lungs is we're compromising our ability to simply recover. And so that's why it's such an urgent situation. And I didn't I don't think we mentioned this before we moved on here Ken. What we're describing here is a acute respiratory distress syndrome. And so that's ARDS. You may hear people in the news reference, acute respiratory distress syndrome or ARDS. This is kind of more or less getting to the point where we're spiraling a little out of control as far as the lungs are specifically. So let's look systemically or all over the body. Remember interleukin one and interleukin six. Well...Those were the the initial inflammatory mediators set off when the virus attacked the type two pneumocyte, then the response of that is to release these inflammatory mediators.That's correct. And they were picked up by the capillary beds. And now remember, they're not just working locally. If we have a large portion of the lungs, releasing these same mediators, they're going to eventually make their way to the central nervous system or the brain and spinal cord. They're going to trigger the hypothalamus, which will then release prostaglandins, that raises your body temperature. And guess what, that's what we end up turning into a fever. And unfortunately, fever is just going to be more work. It requires more metabolic work for your body. So we are still yet increasing the demand for oxygen. We as we referenced earlier, PaO2 remembers just a simple shorthand for the pressure of Oxygen or the number of oxygen molecules in the artery. It's low. So this is hypoxemia. Now the trigger that Lucas had whenever he ended up producing red blood cells was they his chemo receptors, noticed that they were a little bit low on oxygen carrier, so they produced more red blood cells. The chemo receptors here are going to try that. But in the interim, they're also going to trigger the sympathetic nervous system. And when they do that, that's going to set off anxiety, getting people a little bit worked up, but it's also going to be don't forget the sympathetic nervous system is your fight or flight response is going to increase your heart rate, it's going to increase your respiratory rate. That is just more work. The demand for this oxygen just keeps going up.And all of that just on that last slide there, Eric, remember that the heart rate is that that's compensatory, because it says we're not getting enough oxygen. So if I pump faster, we'll at least get more oxygen around if I breathe in, quickly I'm hoping to bring in more oxygen in the heart tries to pump it fast. And that just becomes a bit of a slippery slope. And that's where you're going to get into right now.You're right. And think of healthy lung at this point. If we were simply just had healthy lung at just this point and these are the triggers that high heart rate and a high respiratory rate would basically put everything at ease because hypoxemia would be solved. That's not what we're dealing with at the moment. So this is obviously a progressive disease, we have this increase in cytokines, interleukin one, six, TNF alpha, you can have what they call SIRS for short or systemic inflammatory response syndrome. Then this is kind of interchangeably been used with cytokine storm, but essentially, this is what's happening. These cytokines are triggering all levels and manners of other problems throughout the body. And what we have because of the dilation everywhere, is we have a decrease in peripheral vascular resistance, that's just the resistance that we have at the edges of our of our water, right, we have an increase in permeable capillaries that Dr. Brown described earlier just means that they become more porous. That's where we're leaking that blood plasma, the fluid when we leave that fluid that decreases our blood volume. And we have this systemic all over the body vasodilation, so all of the vessels have lost this resistance. And it's because all of the vessels are trying to get more of the blood flow, that basically we're running out of that amount of blood.When I did Critical Care Medicine, the way to think of that when the body's when the body's trying to compensate by trying to get more blood to everything. If you open up the arteries, or if they vasodilate, and you can keep up with it. Then you get more blood flow where it needs to go. But if you can't keep up with it, imagine a hose. You know the hose that has a little nozzle on it. You can run water and that the smaller the hose, the higher the pressure it goes through. If you keep putting on bigger hoses, then it just comes out as like a little trickle. And that's what's going on and that's what creates this hypotension or severely low blood pressure.Now it's a it's an excellent visual. Yeah, it's a high pressure with a garden hose. Same amount of water through fire hose. Not so much pressure.Exactly. Yeah.So just like Dr. Brown just described, we now are hypotensive. We don't have that pressure everywhere. So now we're systematically hypotensive. That comes with its own consequences. It's going to retrigger the SNS as if we didn't need more agitation.SNS-sympathetic system: fight or flight.Thank you for batting clean-up there. Sympathetic nervous system, there poor profusion of organs. This is where things begin to really kind of spiral out of control if we didn't get there soon enough. Okay. So we we have the lungs that's that's a set of organs right? But we've got brain, heart, liver, kidney, also very, very important. If we have poor perfusion we risk getting multi system organ failure or msof. So kidneys liver and heart. Here's here's the the reason why I'm highlighting these is these are the ones and almost in this order which will begin to throw off markers that we can we can sample for with laboratory with laboratory work and see the status of a patient. As kidneys begin to lose perfusion, they will increase our blood, our blood, blood urea nitrogen will begin to increase as well as the creatinine and it's simply because the pressure is not great enough for to be cleared by the kidneys. And the problem is is those are toxic at high levels. We don't we don't need those circulating like that. The liver itself will begin to sustain some acute damage because it's not being perfused and the wastes aren't being carried away. So we have an increase in AST increase ALT and an increase in bilirubin We also may end up detecting later as we progress an increase in C reactive protein. More interleukin six, just in case we didn't have enough of that circulating around your, your liver guy here is going through us and interleukin six as well as possibly some fibrinogen. And then if we get to this point and the heart begins to not be able to perfuse, the myocardium or the heart muscle, the heart could begin to throw off some chaperonin or CKMB markers, very similar to what we would test for for somebody who's had a heart attack. Or they may also, unfortunately be at the point that could suffer uh...Looking at this looking at multi system organ failure. When I was a resident or when I was a medical student, you'd show up and you have to do rounds. And so you'd have your patient the attending would show up. You'd go 24 hours, what's gone on the last 24 hours you tell them you're like okay, well we've got blood pressure has consistently been dropping, we either try and keep it up or we keep an eye on it. BUN has gone up creatinines gone up. We've got a slight bump in the liver test. So far troponin is normal. And that's almost how you would say it because you're like, we're heading there. We have to stop it before. Because once that heart once you start having a heart attack, that's your last. That's that's the thing that's going to really give up, so...No joke. There's there's a, and let's reiterate, before we get to this point, this is why we want you to know what's happening. We don't want to get to this point. We're going to reiterate what we want to steer away from.This is why whenever they talk about the healthcare resources, why it's so important, because one thing that I want to get out there right now, because we're learning data about COVID19. And now it looks like we're getting close to 30%. I've seen some studies when you're looking at the data of young people getting it not dying, but needing hospital facilities to stop them from going into multi-organ failure. So it is no longer just very old and sick people, they just have, they already walk in before all this starts happening with some other underlying problem. We believe that's why they go into multi-organ failure quickly. So this is relevant for everybody, that this is why we need to make sure that we continue to practice social distancing so that we do not overwhelm the health care system 100%.That's, that's what we're trying to work against, for certain. So let's look at this patient right quick. We've had a decrease in oxygen. Remember, our lungs are damaged. And I've kind of just made a summation of the workload, these are the demands, we've increased the work on the work of breathing, the fever, the heart rate, respiratory rate, the anxiety, not to mention, the organs are starved for it. We've got hypotension everywhere. We're in a little bit of trouble here. So come in, whenever, certainly when it's appropriate, and you have the right signs and symptoms which we've addressed in in the COVID files one and two and two and a half. But what will happen if you end up getting managed in this particular situation, first, they're going to try to find out how much fluids that can give you to resuscitate some of that blood volume. And it's not just as easy just giving you what's missing because remember, we have permeable capillaries, giving too much of fluids. This is a delicate balancing act, giving too much of the fluids could actually exacerbate or make the problem worse with some of the interstitial fluid bonds. So we'll be using some medicines as well. Some medicines that will help what we call pressors to bring your pressure up some diuretics to help pull off some of the excessive fluid. So there's there's a significant balance there, butIt just shows why people like you get subspecialty training and ICU doctors and pulmonologists that anybody that works in a critical care unit. That's why it's so important. They're really good at this and there's an art to it, and it requires definite increase learning not just this is what's a little bit scary. If they ask a gastroenterologist like me to come in and say, hey, look, we're losing people, we need your help in the ICU. One of the reasons why we're doing this is because as a health care worker, I feel like I need to refresh myself on things that I've not done in a long time. That's a really good point, because a lot of what you do is a long term solution as you take care of the patient and a lot of what I do both in anesthesia and then whenever we were doing critical care is, it's very acute. It's very short term. Most of the medicines we use are, I mean, they're they're instant, they're in and they're gone, right? So it's very much like that. So what happens after this is fluids and medicines aren't going to do it. Well we need to ventilate, which is how we breathe, duh. But if you can't do it on your own, we're going to look at mechanical ventilation. That essentially means that we're going to have to insert an endotracheal tube to control the airway now. Ken at a later time or if we have enough time today, we can talk about some of the alternatives between just breathing room air to this but for this particular episode not to get too far, let's just go straight to ventilation if that's okay.Absolutely, yeah. Okay. Because that's that that's what everybody's been hearing on the news also is just we're gonna run out of ventilators.Well, yeah. Very, very good point. So some of the other stop gaps in between the cpap, the bipap and in high flow in the tents over the head. Those are all great if they work. I mean, goodness gracious, high flow nasal cannulas absolutely but there's there's peculiarities with each one of them. The critical part here is we just don't have enough ventilators if anybody gets pushed to this area. So we're going to have to connect that endotracheal tube to the ventilator. And you're gonna love this drawing. I mean, anybody would obviously recognize this anywhere that's that's definitely a ventilator, or a flux capacitor.Yeah, I was gonna say it looks more like a flux capacitor than a ventilator but...The blue represents the endotracheal tube that goes down through the trachea there, but I want to call your attention to one small thing, that little bitty red circle represents a balloon. We...after we put a tube into someone's trachea, we actually inflate this little balloon, and it secures the tube in place. And it gives a true closed circuit meaning air is not breathed around it, we can now control the ventilation. And in this particular case, with such a contagious virus, we can prevent the spread of the virus from coming out of the lungs and through the mouth of nose because it's closed.That was the that was the big argument in the very beginning. Is this just droplets or can this be aerosolized and in the beginning, it felt that possibly if you don't have a closed circuit, then you're allowing somebody to aerosolize it in a room. And now we're putting healthcare workers in a room with higher amounts of virus and so the likelihood of getting infected without proper protective equipment. I think that's why health care workers are our frontline people and they're putting themselves they're heroes because people taking care of these patients especially in the beginning, that's why so many Chinese doctors died when they didn't realize what they were dealing with.Yeah, it's it's a pretty hairy topic all around and the intermediary steps to getting someone from, you know, being able to walk around to the event, where do you stop and is there enough...is there enough PPE for the others outside of this little bitty ballooned cuff to handle that? Some things that we're going to do with and I don't want to get too deep here, but some things that someone would do when they when they put somebody on a ventilator is they would have to look at small measurements, one called tidal volume, that's just the amount of air that you're breathing in and out with each breath. If the if, for instance, the average 70 kilogram person takes in around 500 to 550 milliliters or cc's of air, which with each breath and blows it out at rest,So that that's just your normal breathing. So everybody that's listening to this, their breathing normal, that is your tidal volume. That's what you normally do.Correct. And the amount of times that you breathe in a minute is just a respiration rate. At rest, relatively healthy people, adults about 12 to 14 times a minute. So you can see something here though the bottom two minute volume and PEEP, those are those are our calculations and and therapies that are specific to a ventilator and minute volume is simply the respiration rate times the tidal volume. So if somebody breathes in and out 500 cc's, and they do it 12 times a minute, their minute volume would be six, six liters. Does that make sense?It does. And I think the key here is the PEEP because this now the physiology that you taught in the beginning, pathophysiology. This is where the PEEP becomes really interesting.Yeah. So let's, I'm so glad you said that. So everybody remember PEEP, we're going to address it. This is what the vent can do for us, and that we can't do with without it, okay. So just just looking at what we would do with someone who happens to be sick and dealing with an ARDS situation acute respiratory distress syndrome, we've lost some of the lung availability, so we can't put in the same volumes as normal. So we're gonna have to turn it down. But we want to maintain a relatively close minute volume. So we're going to increase the respiration rate to make that equation somewhat balance out. Now, that's just to get us started. Granted, we will be able to check what we call arterial blood gases and make certain that we're doing it the right way. And we can check our therapy but at the same time to get someone set up. These are some of the calculations that we would make, but what we're going to do is begin to apply PEEP, okay, and I'm going to break that down here in just a moment. But first, you may wonder why am I seeing people on TV or why do I see someone that I know who's being treated for ARDS or specifically COVID ARDS in this prone position. Prone means face down spine to the sky laying on their abdomen or stomach, and getting respiratory therapy. If you recall, I drew the heart earlier in one of the earlier slides, and I showed that the heart is located a little anterior, so towards the front, and a little bit over to the left. But essentially, when you lay on your back, that gravity is still pulling down on the heart, you're you're kind of occluding a good portion of the lungs that lay along the back part of your body. Does that make sense?It does and I think that this is something that we need to get through because this may be early intervention. We're seeing a little bit more of this, and here's why.Yeah, so that's exactly right. And something you can actually do at home, even if you're not feeling great. Recruitment I've written on here, increasing recruitment, recruitment just simply means I can make use of these alveoli all those allow the alveoli everywhere else. If I can use them, I'm recruiting them to be a part, right. So if the heart is more anterior and I'm getting more exposure to more lung tissue that's still healthy, I'm increasing my recruit. So we're going to have to monitor for status after we get onto a ventilator. Like I said before, we're going to look at arterial blood gases. These are just figures that we look at. I'm going to show you the numbers but you don't have to memorize them of course.You make it seem like it's a test.I know, I know, I want everybody to write in email. If you can recall this you can recall this slide. Normal pH which is how we measure our acidity or bass or alkalinity is 735 to 745. CO2 is 35 to 45. That's that's what we breathe out. HCO3 is bicarbonate. Okay, that's what our kidneys are doing to help give us balance. But remember, they're not being perfused so they're not really making it like they need to in our PaO2 we've referenced it several times, but that's the pressure of oxygen in the arteries. It's normally for a healthy person. 80 to 100. Well, this is what it looks like when we run the first ABG, we're going to be acidic, because we're not getting rid of waste gas, and we're not producing enough bicarb. Okay. And so our oxygen is really what we're going to have to get control of first. And then we're going to work towards a better acid base balance as we as we treat the patient.So for non healthcare workers. This is an arterial blood gas. This is a measure when somebody is in the ICU. And these numbers tell a story, depending on what's happening, they say if you're getting slightly better, slightly worse. And by the time what's really cool, as I'm looking at all of this, usually there's involvement of multiple specialties, helping out which is why one ICU person can occupy possibly a critical care doctor, possibly infectious disease, possibly a nephrologist-a kidney doctor, and they all look at these numbers and make decisions and tweaks on the patient. This is just shows how complex a patient in the ICU really is.Without question. Positive end-expiratory pressure. This is our PEEP. This is PEEP. So we drew attention to the few slides back. And if I've done a little bit better job of putting them in the correct order, we would've hopped straight to this. A healthy person when we bring them into, to the OR, and we end up having to use intubation or something like that. Super healthy, you may not have to give PEEP at all. Generally, people end up having, you know, two, three, and all the way up to five. A healthy person can have up to five centimeters of water of pressure and just represents pressure, but just look at the five. And what that does is that holds open the alveolus after you've expired gas. Now this is kind of important in that when we breathe and you're healthy, remember at the very beginning so your diaphragm pulls down, you're pulling air in your chest wall, is expanding out. It's literally pulling an external force outward to create a negative pressure to pull air in. Well, that doesn't happen with a ventilator, we're having to force air in. So we use people and healthy people, just so that we can keep recruitment up of healthy alveoli already. Well remember, right now we're not only fighting the fact that we're pushing air in, we're actually fighting the fact that we've got fluid trying to leak into our healthy alveoli. And if we lose an alveolus to consolidation, it's 99% chance that we are not going to reareate or re-recruit that alveolus we end up just losing it. So somebody who is already in ARDS, we're going to start start at 10 to 12 centimeters of water pressure for P and that's a healthy dose of P and does a few things for us for certain it keeps the alveolus open. It allows us not to give too long of a period of time of high flow oxygen which is 100% oxygen and that's a whole that's a whole 'nother issue. But it really will allow us to save good good parts of the lung. And I should say here Ken, there are possibilities of applying PEEP, where you're not necessarily intubated somebody with a cpap or bipap mask on this solely secure. You can still experience PEEP in that particular situation or even I think some high flow nasal cannulas are credited with some some portions of PEEP.So yeah, so just the whole PEEP thing was always confusing to me when I was studying it, but the way the way that you're describing it, we know that when these alveoli start to go through that whole process that you talked about in the beginning, capillaries start dilating. Well, these, it starts to put pressure on the alveoli. And by the PEEP, you can actually force that alveoli to try and maintain at least some gas exchange so that the leakiness and the fluid creeping in doesn't win. It doesn't completely close off the alveoli.100%. It's this, the PEEP is...you're exactly right. The peak is literally there, not only to keep the alveolus open, but in this particular situation on an ARDS patient, we've increased it because we need that extra help to help keep that fluid at bay in the capillary bed. We're not we've already lost the part of the lung right now during this disease state that we can't re recruit while it has fluid in it and is going through its consolidation phase. We need to maintain what we still have. So I wrote right here, increase area recruitment, maybe. It's a really, really, really slight, maybe. We're doing that but by proning and turning down. We're doing that by oh, and Ken you've seen these beds before, there are beds that actually are are specific for ARDS patients where you lay them in prone, but they actually turn them from side to side and move them around. And that's literally to increase and maintain the area of recruitment,And those are very high level high specialty beds, specifically only for this type of patient. And there's if we are, we have few ventilators, we got even fewer of those real specialty beds.That's exactly what I was thinking. But we our main job here with PEEP, our main job here with the ventilation is to preserve the area of recruitment. And of course with the PEEP like as I mentioned earlier, we want to decrease the need for 100% O2. Some people have even even to ask why. Why would you want to do that? The here's the danger of the fine line here working through mechanical ventilation. Yeah, so to higher pressure. So we want to be able to dial in and give someone enough of the air that they need to ventilate. We've lost part of the lungs, so that's going to increase the pressure if we don't dial back the volumes etc, etc. Just remember, if we are apply too much pressure, we can actually spread ARDS because we're causing damage to healthy tissue. If we give 100% oxygen for too, for too long, we can actually spread ARDS because it leaves reactive oxygenation species, which is exactly what the neutrophils were using to destroy what remained of the virus and unfortunately, healthy tissue. I know this is not ventilators are not like the way I treat a microwave which is just on high every time and just turn it on and let it roll. Ventilators...it's such a it's such a nuanced art. And, you know, and nobody's discussing that on the news where they're like, you know, we're going to run out of vents Well, we're also going to run out of people like you that know how to run these vents. So, you know, and I, this was not to scare anybody, this is not to get too sciency. You and I talked about this. I feel that here on gut check project COVID files, we see that there are going to be some doctors. And when I was watching the Joe Rogan show, they were they were talking about how doctors are stepping up, they're switching and trying to help out in this area. And I know that there are probably some doctors like me that are like, okay, I want to help out. There's going to be or if we get recruited to get in there, then I better do a refresher course. And all I have are a bunch of, you know, really old textbooks that will take a long time to get through. This is just the beginning of something so that they can at least go talk to a family member maybe so that maybe other people will go oh, I understand why my grandpa's on a ventilator now, not necessarily to COVID. This is just what happens. So I really appreciate you taking the time to do that. I think this is the opportunity to teach a lot more people about this kind of thing. And hopefully this will spread with some healthcare workers. So it will make them feel more comfortable.And when I told you that was a a because you only asked me a couple days ago if I could, if I would consider, you know, kind of throwing these together and, and I threw something by you. I said what, what would you think if somebody kind of had an idea on something they could implement that actually would be positioning, but not necessarily related to ventilation? And then you threw out the idea of what how did you say if you feel like you're getting sick, and you're not feeling well get ahead of the curve, lay down down on your stomach...why you kind of talk about...Well, it was just one of those things. So an ER doc did an observation. And he he published something where he showed that he actually published it on Twitter, of a patient on there in the prone position on their phone, kind of said when she was on her back, she was struggling. So when when she rolled over, she could breathe easier. I think one of the problems is when we feel real sick, and we're just laying in the same position the whole time by rolling around and at least laying on your stomach for a bit...then you could switch to your side and back to your stomach. This is the same thing you're talking about this could actually help recruit. And in the early stages might be able to buy a little time. And maybe ER doctors watching this would understand, okay, if somebody comes in, put them on their belly, then we can do some of these other things like high flow nasal cannula, or this this particular guy was looking at it and he was trying to give a whole flow gram of what he's been doing, and preventing people from going on ventilators. So it's a it's a really cool concept. And by understanding the pathophysiology that you explained...now that makes sense, why that could be a way to help people out.It's interesting that you say in that in those terms, too. And what it is he's doing with the flow gram because it reminds me back when I first started helping manage some, some ARDS patients. We were told that it's just not common to have to get into this. It's not commonplace to have to always do ARDS patients. It's usually your larger hospitals that really kind of encounter those right? Yeah.So being reminded of that, I will say that the one takeaway I had from well over a decade ago is whenever somebody is in ARDS, they can't be proned fast enough. They they cannot be proned fast enough, nobody will say that's too early, you know, actually getting ahead of the curve. Recognizing that you're having a loss of gas exchange real estate built, get some for yourself lay down on your stomach begin to breathe. It doesn't matter if you look a little funny. So what saves your life. But if you began to feel sick or have shortness of breath while you're waiting for someone to go and seek help for you, get yourself in that position so I mean, ER, home, waiting to get a ride,, whatever it takes.Because well, yeah, I mean, so if this actually pans out, this may make a big difference, especially if what what he discovered. So we have a lot more cpap machines available and bipap machines, which are just the same thing that many people have obstructive sleep apnea. If what he's suggesting is that he's seen people he'll put prone put them on a bipap or a cpap machine, increase the PEEP. Basically that's what they're doing is increasing the PEEP, put them on a prone position and saving them from going on a vent. There's a lot of people with cpap machines next to their bed including this guy right here talking. I've got apnea, and I wear a little nasal pillow. I know I'm not alone because Chang Raun did a social media post about how people if you have sleep apnea, then you're going to be at risk for developing something, also. So make sure you wear your CPAP machine if it's dusty in the closet.Yeah, that article. I found that really interesting how, how well he described being able to do some of the intermediary steps to cpaps the high flow nasal cannula. I don't disagree with the thing that he's saying the and he even addresses it in there. If you could just simply answer the question of the danger of the aerosolization of the disease versus preventing someone from having to get some mechanical ventilation, but the one thing he uses that several people still do is the rocks equation know the threat. But essentially you're taking some status measurements to see...okay, are we beyond any of these intermediary steps, do we need to move to a ventilation? But I think I think that his piece is...it preserves equipment, it still requires people that don't feel well, they feel like that they're beginning to lose their breath to go seek help now.Yeah, that's, that's, that's the key people are like, well, when should I go in? And, you know, the ERs are trying to say, well, if you've got a mild fever and see if you can ride it out if you can do this, but the second any shortness of breath starts happening, I think you got to get in and get some of this equipment on you to prevent you from going into ARDS. It's almost like you have an obligation to get there before because it's becoming a slippery slope, then.Hey, you know, Mike wrote that question over to you and I and he was asking specifically about the healthcare worker, and younger people, you and I kind of have similar takes on what we think and maybe maybe slightly different. Did you have an idea on what you thought could possibly total theory but just could possibly be lending itself to younger people or healthcare workers? Yeah, I mean, my my view on the healthcare worker is just repeated exposure and repeated exposure and repeated exposure. You took a little different take on it on the workload. So tell, go ahead and tell me your take on that one.I mean, I number one, I completely agree with repeated exposure. I think that somebody who's healthy and they're a healthcare worker, they probably can fend off a couple of small assaults, right. But if it's continuing to attack other healthy pneumocytes, kind of what we laid out today that you're going to initiate a cytokine storm, unfortunately for somebody else who had they just small, you know, had a small encounter probably wouldn't even notice that they have been contaminated. But yes, the workload, ultimately, that's, that's the sign of failure for really any organ system is their workload, and there's just not enough supply whatever that supply happens to be for any one of our organs. So when the lungs just simply cannot produce and share enough oxygen for the rest of the body, but the rest of the body is churning and it's programmed responses to basically kind of amp up. It's a tough scenario to work out on one's own without some medical intervention for sure.Mm hmm. And that's it. So that's a really good point that maybe the healthcare workers themselves number one, repeated exposure, but number two, are still yeah, they're still running around still, you know, busting their butt and, you know, maybe subtle changes in that tidal volume like you're talking about is really what what starts the downhill, slippery slope. So, but it's so you know, the whole point is to educate on this and hopefully, if a healthcare worker gets something out of it, that's why we're doing this one. Normally, I think you and I try to be a little bit more lighthearted and jokey but I asked you as a favor to me to refresh my memory. So thank you very much for doing that. I've I'm dusting the cobwebs off, but I think that...If you have any specific questions and if I can answer them, shoot, I don't mind answering questions about vents or any of that kind of stuff. So any questions about any of the episodes you know, you can always email us at kbmdhealth.com go to contact us and let us know or gutcheckproject.com same thing. Well, probably...You know what, I mean I think that's thing once we get on Instagram, I have a I would like if anybody is a healthcare worker, a respiratory tech or an ICU doctor and ICU nurse and we got something wrong let us know because...Oh, yeah. This is this is not you know. My specialty is a gastroenterologist so this is a learning curve for me on this one, but yeah, I think we did. We're right at about right at about 55 minutes or so. So we try to keep this around an hour we you know, and see what we can do and you covered a lot of material in an hour, so that's awesome. That is absolutely awesome.Hey, man, my dry erase board is worn out.Yeah. Oh, Yeah, because you would have to erase...oh, you only had one.Man it was it was it was draw, take a picture and then wipe it away. Yeah and unfortunately I didn't have I didn't have Gauge or Mac available to help me kind of sketch those out because those are really really rough Picassos I just threw together.Yeah and you know what it looks like your drawing skills were just starting to improve if you would have done a little bit started looking like real lungs. If only you knew how long it took me just to print the words I used.Well, that's awesome. All right, well, I'm gonna call this our COVID-19 file number three in the books. Share it with somebody if you think that they could benefit from this information. So great job, Eric. We'll see y'all next time. Thank you.Take care.

Chronic diarrhea, constipation, gas or bloating; arthritis or joint pain; nutritional deficiencies; autoimmune disease; headaches; brain fog; memory loss; excessive fatigue; skin rashes; acne; eczema or rosacea; cravings for sugar or carbs? You may have leaky gut or intestinal permeability. Learn about what it is, why it happens and how to fix it with Certified Health Coach Lindsey Parsons, EdD. Show Notes

Learn about the most common parasites found in stool samples in the U.S., why parasite testing through your doctor will likely miss parasites you may have, symptoms of a parasite infestation, treatment options, and how to get testing for parasites and candida via ParaWellness Research with Dr. Raphael d'Angelo, MD. Lindsey Parsons, EdD, the host, helps clients solve gut issues, reverse autoimmune disease and type 2 diabetes naturally and lose weight without cutting calories or cutting out major food groups. She's a Certified Health Coach at High Desert Health in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on Facebook, Twitter, Instagram or Pinterest or reach her via email at lindsey@highdeserthealthcoaching.com to set up a free 1-hour Healthy and Sustainable Weight Loss/Health Restoration Breakthrough Session. ParaWellness Research: http://parawellnessresearch.com Keto Kube bread from Uprising Foods: https://www.uprisingfood.com/ Lindsey Parsons' Fullscript Dispensary: https://us.fullscript.com/welcome/highdeserthealth Functional Health and Nutrition Review with Lindsey: http://highdeserthealthcoaching.com/functional-health-and-nutrition-review/ Health Coaching Breakthrough Session with Lindsey: http://highdeserthealthcoaching.com/healthcoaching/ Lindsey's Gut Healing Facebook Group: https://www.facebook.com/groups/gut.healing.for.you/ Lindsey's Healthy and Sustainable Weight Loss Tucson Facebook Group: https://www.facebook.com/groups/614864552264400/ Tucson Reversing Autoimmune Disease Together Meetup: https://www.meetup.com/Tucson-paleo-Meetup-Group/ Links to Lindsey's affiliate shops, lab tests and recommended products: http://highdeserthealthcoaching.com/supplements-and-lab-tests/ Lindsey Parsons' web site: High Desert Health: http://highdeserthealthcoaching.com and email: lindsey@highdeserthealthcoaching.com High Desert Health on Facebook: https://www.facebook.com/HighDesertHealth/ High Desert Health on Instagram: https://www.instagram.com/high.desert.health/ or @high.desert.health High Desert Health on Twitter: https://twitter.com/HDesertHealth or @HDesertHealth High Desert Health on Pinterest: https://www.pinterest.com/highdeserthealth/ Credits:   Thank you to SoundDot for the music on the podcast: Royalty Free Music: www.soundotcom.com

Woody plants with lots of fiber can be a tough hurdle for someone with a damaged gut. And yet, it’s that very same fiber that research indicates is the key to healing some of our biggest overarching gut problems. It can feel like a fine line to walk. Today Dr. Will Bulsiewicz is on the show to help us navigate that tightrope. In our conversation, Dr. B explains why fiber is the key to healing dysobiosis, leaky gut, and inflammation. He’ll also talk about how SIBO Amigos who have been taught to fear fiber during treatment can slowly condition their guts to handle all manner of beneficial plant foods. In addition to being the author of the new book Fiber Fueled, Dr. B is also a highly decorated gastroenterologist with over 8 years of formal research training. Through his own experience losing 50 pounds after changing his diet, he began integrating a plant-based approach into his private practice and witnessed some amazing results with his patients. If you've been wary about how to integrate carbs and fiber into your SIBO healing, this episode will set the record straight. A quick taste of what we’ll cover: Macronutrients 101: the difference between fiber, carbs and protein in the body How soluble versus insoluble fiber moves through our system Short Chain Fatty Acids and why they are so important for the health of our colon Why food sensitivity tests fall short in accounting for immune reactions The prebiotic supplements that Dr. B uses in his practice How to ramp up your fiber intake slowly to prevent syptoms And so much more... Resources, mentions and notes: Dr. B's website Dr. B's new book, Fiber Fueled Studies on prebiotics and lactose consumption | Part Two Items in Dr. B's prebiotic medicine cabinet: Acacia fiber, Partially Hydrolyzed Guar Gum, Beta Glucans EP 06 – Prebiotic and Probiotic Protocols with Dr. Jason Hawrelak EP 23 - Elemental Diet with Dr. Michael Ruscio Phoebe’s book, The Wellness Project, on her journey with Hashimoto’s Join the SIBO Made Simple Facebook Community Page Subscribe to receive a free low FODMAP cookbook   This episode is brought to you by Epicured, a low FODMAP meal delivery service that understands that food is medicine. Each menu is created by Michelin star chefs and honed by doctors and dieticians at mount sinaii to restore digestive health for those with IBS, SIBO, Celiac and IBD. Everything they serve is 100 percent low FODMAP and gluten-free, with no cooking required! My favorite part about their dishes is the healthy spin on takeout gems like shrimp laksa and PAD THAI! Their version had a great balance of fresh veggies mixed in with the noodles that left me feeling both satisfied and completely free of my usual carb coma. Listeners to this podcast can get $20 off their order by using code PHOEBE. Click here to learn more.  Disclaimer: The information in this podcast does not provide medical advice, professional diagnosis, opinion, or treatment. The information discussed is for educational purposes only and is not a substitute for medical or professional care.

In this episode, the boys are welcomed by guest, Erica Zellner. They discuss everything from gut permeability and gluten intolerance to the interconnectivity of cortisol, sleep, life stressors and high intensity workouts. Erica has a Master's of Science in Nutrition and works as a nutritionist helping clients better understand their unique biological composition. You can learn more about Erica on instagram @ericazellnernutrition or at http://ericazellnernutrition.com/ To learn more about CrossFit SCV, check us out here!

Rowan Sanderson sits down with Dr. Nick Thompson, head of the Raw Feeding Veterinary Society, and Dr. Conor Brady, founder of Dogs First. Together, they discuss the impact of leaky gut (intestinal permeability) on your dog’s health and how it is linked to food allergies and intolerances. They also give you a simple method to solve your dog’s leaky gut issues.  According to Dr. Nick, preventing leaky gut is simple provided one can identify the cause of inflammation or damage to the gut.

Rob, Matt and Patrick hear from listeners about rain barrel spigots and masonry walls resisting soil pressure before taking listener questions on WRBs, insulating walls sheathed with fiberboard, and making French-style patio doors from scratch.  

Struggling to improve your gut health and metabolism?  Research has shown peptides to be a novel treatment to address your gut health and metabolism.  From ulcers, acid reflux, wound healing and leaky gut the peptide BPC 157 has show to yield a speedy recovery.  At the same time research on the peptide MOTS-c has shown to boost metabolism, improve insulin sensitivity, enhance exercise recovery and counter menopausal weight gain.  In this episode Dr. Jannine Krause discusses how she is using both of these peptides to restore her gut health and boost her metabolism.   What You’ll Learn In Today’s Episode: Why BPC 157 is key for optimal gut health Why combining BPC 157 with nitric oxide boosts healing How MOTS-c lowers glucose How MOTS-c improves exercise recovery  

As Sports Nutritionists besides having to properly fuel cyclists during training and racing, there is also an additional challenge we often face. And that challenge is to try our best to minimize GI symptoms in cyclists. We can prepare a rider for months but if one key meal in a moment surrounding or during the race goes wrong, we can jeopardize months of preparation and condition the rider’s performance for that day. On the other hand, we must make sure these athletes ingest a rather high amount of CHO-rich foods while on the bike in order to be able to sustain higher intensities in latter stages of the race. But this high exercise intensity and high quantity of ingested CHO are also some of the main factors that can also limit gastric emptying, CHO absorption and lead to some GI symptoms to occur, which may have serious consequences for cyclists. On this episode Dr. Jamie Pugh helps us understand the main causes and practical strategies to minimize GI symptoms in cycling. That is why the name of this episode is "Feeling lighter from start to finish..."

A toke with RJ about the complexities of Gut Permeability and Ayurvedic Healing. We also get deep into the lies and deception of NASA and other space agencies.

Today I am giving you an inside look into one of my very own lab tests and my personal results. Labs are an amazing tool we can use to get a better look as to what is going on inside of our bodies. Today I am taking you through my microbiome test results to see what kind of bacteria I've got going on inside of me. Plus how I can implement certain foods into my diet to help increase the ones I want and decrease the ones I don't. Things Mentioned in this episode: Organic Genetics FEBI Test: www.organicgenetic.io  Use Code: DetoxwithDani to get your review of findings appointment with me!  30 Minute Consultation with Dani - Schedule Here Please Subscribe & Leave a Review :) (asking nicely) Want to get notified when a new episode is released and get the inside scoop on how to have gut health, glowing skin and a gorgeous YOU?? Click here to subscribe to the podcast on: iTunes Stitcher Google Play It would mean so much if you would leave a rating and review. I would love to know how I can make the podcast better and bring you the topics, tips and tricks you all want to hear about. Plus leaving a review helps get this information in front of so many more people who need to hear it.  Thank you so much for listening and taking the time out of your busy schedules, I hope this has been helpful!  xoxo Dani   This podcast is not meant to diagnose, treat, cure or prevent any diseases.

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I’m looking forward to sharing with you some of our community’s questions that have come in over the past few weeks… Let’s get started! Lauren: Hi Dr Cabral, First, thank you! You continue to help me daily! This question is for my sister. She is 32 and after doing a month of whole 30 she found out she has a mild case of crohns in the tail of small intestine. She only got ct scan and colonoscopy with biopsy. The gastro told her to take lialda 1.2 (2tablets a day) and budesonide 3mg (3times a day) for two weeks while she is overseas and then come in to discuss treatment. I am very anti this as the doctor never discussed why she has all this inflammation in the first place. For background she also found out she had HSV-2 3 years ago right after she randomly got shingles. for the HSV2, she takes valtrex as she thinks its the only way. She has also been on birth control for 15 years. I believe since she started Valtrex, her stomach has been in shambles and her hair appears to be thinning. The doctor took her blood work and said everything seems 'fine' but she has elevated testosterone. First, Can you please recommend what she should do for crohns as well as what foods she should eat/avoid .. I want her to see a nutritionist to see what she can eat and/or a functional doctor or better yet you despite living in NY, to test for food sensitivities, organic acid test, heavy metals, thyroid etc. Secondly, can you please recommend the absolute necessary testing she should get done and how she can go about NOT taking these harsh treatment drugs doctors typically prescribe. I have a feeling her immune system already is poor and those treatments will make it worse and lead to later bigger problems. Third, could the valtrx and birth control and HSV2 in general be something causing the crohns? I want her off those medicines but I figured she may respond better to you rather than me telling her! Thanks in advance!! I really want to help her as she is overwhelmed and needs direction on what exactly to do/eat etc. Lori: Hi Dr. Cabral. I’m so glad I found your podcast. I tell everyone about it and love passing on information to them that I think will help them - I have a question about my loud stomach. My stomach seems extremely loud after I eat, but there’s even times when I haven’t eaten anything and it is still making gurgling noises. I drink a smoothie every morning using your daily nutritional support, and I just ordered the fruit and vegetable blend. I tried using the probiotic in the daily protocol but it made me so bloated and uncomfortable that I stopped taking it. My diet is okay. It could be better but I don’t eat red meat, have occasional chicken, and eat mostly fish. I don’t eat a lot of processed food, and I do some form of exercise every day, either rowing, elliptical, weights or yoga (my favorite). I also try to meditate daily. I do get heatburn and maybe 5 years ago I was put on Zantac every day. I went off after a year or two because I felt I didn’t need it anymore. Ironically, I was put on high blood pressure meds a few years ago even though I am not overweight and have no other risks factors other than high bp readings at dr.’s office. I’m 5’7”, 135, workout daily, limit salt, no red meat. In your podcast 108, it said low stomach acid could be a cause. I monitored my bp for one month at home and had very good readings. I brought that info to my pcp and he said I could possibly stop, which I did. I’ve been monitoring and am having good readings. It’s been almost 4 months that I’ve been off all medication, not even over the counter Tylenol. I’m wondering if you think my loud stomach is because of an overgrowth and should I give the probiotics another try? It really made me very bloated and it was very uncomfortable. Thank you for your help. I look forward to hearing what you think I should do. Deb: Dr. Cabral, I am a new 'convert' to your wealth of health insights thanks to friend Lisa. I am 68 female with Hashimoto's who has osteoporosis in both hips and osteopenia in spine. I have resisted taking any of the bisphosphonates or Prolia in the 15+ years I've experienced bone loss due to all the side effects. I eat healthy mostly Mediterranean diet (and no gluten, soy, or GMOs, eat organic 90%) and focus on exercises that will strength butt muscles and take 'all the right supplements.' A functional medicine osteoporosis expert proposes (while not a fan particularly) I take Prolia for 1 year and follow it up with a year on Fosamax reasoning that Prolia DOES build bone BUT if you stop it you are at greater risk of fracture. My integrative PCP is proposing Prolia and does not like bisphosphonates. What is your advice please? Sarah: Hi Dr. Cabral, I recently got introduced to your podcast through your interview on Jay Ferruggia's podcast and I've been tuning in often to your podcast ever since! I've also been sharing it with my friends and colleagues and family members when I hear something on your podcast that might help them! So thankful for your insights and simple, straight-forward approach to healing. Over the last year I worked with a nutritionist in the Ottawa, Canada area (I also got him hooked to your podcast). Together we identified many food sensitivities (through electrodermal testing) and I changed my diet and approach to food drastically since then. (I'm trying to get my family on board but that has been a bit more challenging. But that is a topic for another day!) I saw immediate and ongoing amazing results. I am 5'4", athletic body type although small, and when I was a teenager weighed around 105-110 lbs), but after my 2nd child I kept gaining weight and couldn't lose it even though I kept increasing my exercise and work-outs and considered myself to eat very healthy. I had reached over 130 lbs, felt tired all the time, and was experiencing early signs of depression. Removing the foods I was sensitive to, I lost 18 lbs in around 3 months, and I recently lost that last stubborn 5 lbs after a bout of the flu (I am now back to 108-110lbs!). I have more energy and more zest for life, etc. Among my food sensitivities are the usual culprits but also a curious list of fruits and vegetables: gluten, oatmeal, corn, soy, dairy, pork, tomatoes, peppers, eggplant, zucchinis, all legumes, papayas, mangos, kiwis, bananas, coconut products (except oil), sesame oil and seeds, garlic, food additives and stevia, etc. But I still experience frequent bloating and gas and sometimes constipation after having a "cheat meal" no matter how small the "cheat" ingredient is (which is on my food sensitivity list). The funny thing also is that my food sensitivities seem to change every few months. I also still struggle with psoriasis on my scalp - that has not gone away (had it for nearly 10 years now) and still is itchy even after 14 months of being on my program. I recently eliminated caffeinated coffee (still have decaf) and alcohol but this didn't seem to do anything. I have sugar maybe once a week in a larger amount, usually it is a teaspoon or less per day. I eat vegetables and protein every meal (usually meat protein since I can't do legumes) and do starch for lunch and dinner. I recently stopped eating between dinner and bedtime (and changed my bedtime routine based on your diurnal rhythms podcast episode. I go to bed close to 10pm and I naturally wake up close to 6am sometimes before. Whereas before I was so tired no matter how late I slept in!) I take magnesium glutamate (2 capsules before bed), a Vit B12 supplement (bought at pharmacy, Jamieson brand - my physician had identified low B12 levels through blood work before I started my diet change), and a Vit D3 supplement (also bought at pharmacy). I also take a probiotic capsule every day (mix of bifido and lacto) that my nutritionist gave me specifically for IBD-type of symptoms. I take the odd digestive enzyme before a cheat meal, and during periods of more cheating (e.g. holidays) I take glutamine powder every day. Wondering if you have any specific recommendations on how to figure out the problem around my digestion and my psoriasis (I suspect they are related). I listened to your previous podcasts on psoriasis and also on food sensitivities and digestion related. However, I am not clear what is the best protocol to start with: candida yeast overgrowth protocol, or the detox, and should I do the 7 or 14 or 21 day detox? and then what? (weight loss is not my goal). And, based on my body type, should I be eating a different proportion of macro nutrients? Also, my nutritionist's method did not identify the severity of food sensitivities, so I don't have a good sense for which foods to really remove completely and which ones are ok to cheat once in a while (other than dairy and gluten, they give me constipation for 3 days).Lent has started so this is a perfect opportunity to reset my body and my mind! Look forward to your suggestions. thank you so much. Thank you for tuning into this weekend’s Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes & Resources: http://StephenCabral.com/821 - - - Get Your Question Answered: http://StephenCabral.com/askcabral  

We back for another invertebrate versus amphibian episode. But this time we’re focusing on carabid beetles and their relentless consumption all amphibian life. They have managed to turn the tables on their would be predator in a remarkable case of role-reversal. Species of the Bi-week is a beautiful frog with a fittingly macabre name. FULL REFERENCE LIST AVAILABLE AT: herphighlights.podbean.com Main Paper References: Wizen, G., and A. Gasith. 2011. “Predation of amphibians by carabid beetles of the genus Epomis found in the central coastal plain of Israel.” Zookeys 100: 181–191. Wizen, G., and A. Gasith. 2011. “An unprecedented role reversal: Ground beetle larvae (Coleoptera: Carabidae) lure amphibians and prey upon them.” PLoS One 6: 1–6. Species of the Bi-Week: Dias, I. R., C. F. B. Haddad, A. J. S. Argôlo, and V. G. D. Orrico. 2017. “The 100th: An appealing new species of Dendropsophus (Amphibia: Anura: Hylidae) from northeastern Brazil R. Castiglia.” PLoS One 12: e0171678. Other Mentioned Papers/Studies: Barkai A, McQuaid C (1988) Predator–prey role reversal in marine benthic ecosystems. Science 242: 62–64. Beckmann, C, and R Shine. 2011. “Toad’s Tongue for Breakfast: Exploitation of a Novel Prey Type, the Invasive Cane Toad, by Scavenging Raptors in Tropical Australia.” Biological Invasions 13 (6): 1447–55. Brodie Jr., ED. 1977. “Hedgehogs Use Toad Venom in Their Own Defence.” Nature 268 (5621): 627–28. Choh, Y., Takabayashi, J., Sabelis, M. W., & Janssen, A. (2014). Witnessing predation can affect strength of counterattack in phytoseiids with ontogenetic predator–prey role reversal. Animal Behaviour, 93, 9-13. Escoriza, D., L. Mestre, G. Pascual, and J. Buse. 2017. “First case of attack of an adult Bufo spinosus Daudin, 1803 by a carabid beetle larva of Epomis circumscriptus (Duftschmid, 1812).” Bol. Asoc. Herpetol. Esp. 28: 2006–2008. Petschenka, G, S Fandrich, N Sander, V Wagschal, M Boppré, and S Dobler. 2013. “Stepwise Evolution of Resistance to Toxic Cardenolides via Genetic Substitutions in the Na+/K+-ATPase of Milkweed Butterflies (Lepidoptera: Danaini).” Evolution 67 (9): 2753–61. Scudder, GGE, and J Meredith. 1982. “The Permeability of the Midgut of Three Insects to Cardiac Glycosides.” Journal of Insect Physiology 28 (8): 689–94. Ujvari, B, NR Casewell, K Sunagar, K Arbuckle, W Wüster, N Lo, D O’Meally, et al. 2015. “Widespread Convergence in Toxin Resistance by Predictable Molecular Evolution.” Proceedings of the National Academy of Sciences 112 (38): 11911–11916. Wilson, NJ, AN Stokes, GR Hopkins, ED Brodie, Jr., and CR Williams. 2014. “Functional and Physiological Resistance of Crayfish to Amphibian Toxins: Tetrodotoxin Resistance in the White River Crayfish (Procambarus Acutus).” Canadian Journal of Zoology 92 (11): 939–45. Voyles, J, DC Woodhams, V Saenz, AQ Byrne, R Perez, G Rios-sotelo, MJ Ryan, et al. 2018. “Shifts in Disease Dynamics in a Tropical Amphibian Assemblage Are Not due to Pathogen Attenuation.” Science 359: 1517–19. Other Links/Mentions: Epomis circumscriptus attacking and preying upon Bufo viridis – http://www.youtube.com/watch?v=wFJ_CXJ0qPo Epomis circumscriptus attacking and preying upon Hyla savignyi – http://www.youtube.com/watch?v=RMkFb5n97cU Trophic interactions between Epomis adults and Triturus vittatus –  http://www.youtube.com/watch?v=JA46dbEpluI Videos from Wizen and Gasith 2011 PLoS One  – http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025161 Photos from paper two: http://www.tau.ac.il/lifesci/departments/zoology/Amphibia/new.html Rats vs toads: https://www.facebook.com/groups/ukargs/permalink/2092225931007478/ Music: Intro/outro – Treehouse by Ed Nelson Other Music – The Passion HiFi, www.thepassionhifi.com

Gut complaints are SUPER common in clinical practice. Leaky Gut is also known as Intestinal Permeability and is a common driver of Constipation, Diarrhea, Gas, Bloating, Stomach Pain, and/or IBS. There are many systemic symptoms that can be caused by leaky gut that most people wouldn't associate with it: Food Allergies Autoimmune Disease Fatigue Mood Disorders Etc  

Dr. Will Cole Discusses: What functional medicine is and what functional medicine practitioners look at Why someone going through cancer would want to work with a functional medicine practitioner Identify underlying problems long before they become serious OR get to the core issue of serious problems to truly heal Labs for gut function, toxic burden, methylation and blood tests Clinical application of ketogenic diet as one tool of many Infrared saunas for detoxification and mitochondrial function Resources Mentioned Dr. Will Cole’s website Sunlighten Saunas - Get $150 off for mentioning My Kid Cures Cancer!! Dr. Will Cole Highlight Article Video Interviews and Anticancer How-To’s Anticancer Inspiration  This I feel was a very important episode for the show and for those of you going through cancer to understand as we’ve had reference to functional medicine and guests on who practice it in the past but no straight up interviews on this is what it is, this is what we look at and this is how it can help in contrast or maybe better yet in addition to your conventional care team and even your naturopathic doctor in a lot of cases. Wide ranging interview but a very good overall theme of identifying and addressing core issues to problems that others may miss that I think is going to give you a lot more firepower when it comes to questions to ask health practitioners you’re either currently working with or those that you may be evaluating to be sure you’re really getting the best health bang for your buck possible. Dr. Will Cole who graduated from Southern California University of Health Sciences in Los Angeles, California. He has his post doctorate education and training in Functional Medicine and Clinical Nutrition through The Institute for Functional Medicine and Functional Medicine University. Dr. Cole consults in the Pittsburgh area and phone or webcam consultations for people around the world. He specializes in clinically investigating underlying factors and customizing health programs for chronic conditions.

OPP 96 Guest Dr. Christine Rosche returns to talk gut permeability, stool testing and how leaky gut can lead to leaky brain and have a drastic effect on your whole body. 

Organic whole grains are better, no sprouted grains are better no avoid grains all together for the best health. Which is it? Confused about what gluten is and what it really does to your body? Have you noticed gut issues, skin rashes or puffy eyes a few days after eating a pastry, bread, cereal or crackers? Have you been to Europe or heard from friends that gluten grains are no problem for them over there? What if your issues aren't from wheat at all but a combination of toxins affecting the gut lining? Doc J breaks down how the mix of gluten rich grains, pesticide rich foods, food additives and alcohol affect the body and why it may be the source of your health issues. What You'll Learn In Today's Episode: Why it's more than just wheat to blame for gut, skin and mood issues Why Einkorn wheat is easier to digest How processed foods, food additives, alcohol and pesticides combine in your gut to cause intestinal permeability What to do to keep your gut lining healthy and maybe be able to eat wheat again

Check out IFPodcast.com/Episode4 for shownotes and references, and IFPodcast.com/StuffWeLike for all the stuff we like! You can support us at Patreon.com/IFpodcast - It would mean the world!! We LOVE putting time into this podcast, and every dollar can help us continue to make that possible! Get Melanie's Book What When Wine: Lose Weight and Feel Great with Paleo-Style Meals, Intermittent Fasting, and Wine, on Amazon and Barnes & Noble! Get Gin's Books' Feast Without Fear: Food and the Delay, Don't Deny Lifestyle SHOW NOTES 4:50 - Vibe: Unlock the Energetic Frequencies of Limitless Health, Love & Success(Robyn Openshaw) 7:50 - Listener Feedback: Faye - Ditching The Husband AND Weight, And Gaining So Many Benefits! 11:30 - Listener Feedback: Jessica - UK Organic Wine Reccomendation  Episode 26: IF & Low Sugar/Alcohol/Toxin Wines For Health – Special Interview With Todd White Of Dry Farm Wines! Get Dry Farm Wines - Natural, Organic, Low Alcohol, Low Sugar Wines Which Are Amazing And Keto Friendly!! And With This Link, You Get A Bottle For A Penny! Organic Wine Co: Organic Wine For The UK! 13:25 - Listener Feedback: Hayley - How Do You Deal With The Emotional Components of IF And Giving Up Crutches? The Yoga of Eating: Transcending Diets and Dogma to Nourish the Natural Self (Charles Eisenstein)  You Can Heal Your Life (Louise Hay) and You Can Heal Your Body (Louise Hay) Mantras: I Am Enough, Let Go, This Is Only A Paper Tiger, I Am Peace, This Is Just A Moment, I Am Biger Than My Fear, Look How Far I've Come, I Am Free of ______ 27:25 - Listener Q&A: Sarah - Does CBD Oil Break The Fast Or Hinder Autophagy? Does Peppermint Stimulate Appetite?  How to Make Sure Your CBD Oil is Legal and of High Quality 35:05 - Listener Feedback: Rosie - How Do You Know If You Have A Healthy Gut? Effect of Gliadin on Permeability of Intestinal Biopsy Explants from Celiac Disease Patients and Patients with Non-Celiac Gluten Sensitivity Healthy Gut Heathy You (Dr. Michael Ruscio) 35:05 - Listener Feedback: Rosie - How Do You Know If You Have A Healthy Gut? 45:50 - Listener Feedback: Becca - How To Get More Energy At Night For Morning People? 47:25 - Listener Feedback: Celeste - How To Stop Crashing After Eating? The Warrior Diet: Switch on Your Biological Powerhouse For High Energy, Explosive Strength, and a Leaner, Harder Body (Ori Hofmekler)         For information regarding your data privacy, visit acast.com/privacy

Are you avoiding sugar but drinking diet soda and making low carb sweet treats with sugar substitutes?  Depending on your use of artificial sweeteners you might be doing more harm that good in your quest to avoid sugar or stick with your low carb diet.  Research has shown that consumption of artificial sweeteners, including some processed forms of stevia can irritate your gut lining and kill your good gut bacteria.  In this episode Doc J discusses what's in these artificial sweeteners that are irritating your gut, killing your good bacteria and causing leaky gut symptoms.

Thanks to Dr. Susan Blum, functional medicine has even more to offer for patients with rheumatoid arthritis (RA) and osteoarthritis (OA). She shares new insights about RA’s underlying causes, details what goes missed in treatment plans, and gives practical tips for mining data from stool tests, utilizing functional blood markers, and combining herbs and probiotics to reverse processes that other practitioners may think are permanent

Basics The blood brain barrier is the last layer of cells between what's in your blood and the extracellular fluid around your brain cells. You're born with it!  It's main job is filtration. 2 ways things get through the blood brain barrier: Passive diffusion: small, neutral molecules (water, gases, lipid-soluble) Active transport: glucose, amino acids, drugs (like a revolving door) Permeability: how easily something can pass through a layer without work Things that change permeability: Inflammation - stretches layer and makes holes bigger (meningitis, injury) Multiple sclerosis - an auto-immune disease that can degrade the BBB Alzheimer's - BBB becomes overwhelmed with antibodies and burns out *Scary Section* Rabies is a virus that is small and can get through the blood brain barrier but the immune system cells, antibodies from the vaccine, and medicines can't. HIV encephalopathy is caused when a mutation of the HIV gets into the brain and use brain cells to replicate (rather than the well-known T-cells of the immune system).  There is also a rare symptom of HIV called HIV-associated dementia. Callback microchimerisms - Pregnancy causes the permeability of many areas of the body to change, and this includes the BBB. Test Yourself Drugs that have central nervous system effects (good) or side effects (bad) cross the BBB.  See what you know of different medications and what job they're supposed to do and what negative side effects they cause and see if you can guess if they cross the BBB. Connect with me Support us on Patreon *NEW* Join the Pharmacist Answers Podcast Community on Facebook Subscribe: iTunes, Stitcher, GooglePlay, TuneIn Radio Like the Facebook page Music Credits:  “Radio Martini” Kevin MacLeod (incompetech.com)  Licensed under Creative Commons: By Attribution 3.0  http://creativecommons.org/licenses/by/3.0/

Leaky gut is a concept that the cells of our gut lining are inflamed from the foods we eat, environmental toxins, stress as well as hormonal and nutrient deficiencies. Leaky gut gets it's namesake as molecules of food, viruses, bacteria, fungal organisms, medications and environmental toxins that should stay in the digestive system to be eliminated end up passing through “leaks” in the gut lining to the blood stream. Once these molecules end up in the blood stream the body sees them as foreign molecules and goes to attack them. The body's overactive immune system response causes a host of issues from muscle & joint pain to skin rashes, hives, acne, headaches and brain fog along with multiple food sensitivities.

Neufeld, J (University of Cambridge) Friday 10th June 2016 - 14:00 to 14:45

Mon, 7 Mar 2016 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/19259/ https://edoc.ub.uni-muenchen.de/19259/1/Tanase_Laurentia.pdf Tanase, Laurentia Irina ddc:610,

In this podcast Dr Robert Tarr talks to Dr Matt Gounis and his team Dr Juyu Chueh and Dr Srinivasan Vedantham about their editors choice paper. In this podcast they discuss their methodology and the drawbacks of this kind of study. Full paper >> http://jnis.bmj.com/content/7/9/676.full

Einstein A Go Go - 30th NovemberAndrea from the BOM, Dr Lauren, Chris KP, Dr Shane and Liv on Twitter.News Items: New weather reporting methods, The mechanics in drinking of cats and dogs, Permeability of graphene, new geo-engineering experiments. First Guest: Svenja Kratz is an interdisciplinary artist who utilises traditional and experimental bio-art practices to explore the impact of new technologies and science on concepts of the self, other and the body. Current exhibition until 21st Feburary at RMIT Gallery http://www.svenjakratz.com/Second Guest: Dr Michele Veldsman, Postdoctoral Research Fellow in the Stroke Division at The Florey Institute of Neuroscience and Mental Health. Wikibombing wikipedia's entries on Australian women in neuroscience. The aim is to promote exceptional women in neuroscience and recognise and showcase their achievements.Other news items: the southern oscillation index, seasonal climate outlook, El Nio watch upgraded to alert.Science is everywhere, including:http://www.rrr.org.au/program/einstein-a-go-go/http://rrrfm.libsyn.com/category/Einstein%20A%20Go%20Goand every Sunday at 11am AEST on RRR 102.7mHz FM

Membranes as permeability barriers, and transport mechanisms allowing barrier passage. This lecture is part of Membranes and Receptors, a module in year 1 Medicine undergraduate course.

Nandini Kashyap interviews Dr. Nicholas Meanwell, Executive Director of Department of Chemistry at Bristol-Myers Squibb Co. on March 25, 2014. Dr. Meanwell will be delivering keynote presentation during the 3rd Annual Property-Based Drug Design, May 22-23, 2014 at Westin Boston Waterfront Hotel in Boston, MA. Topics Include: Physicochemical properties in drug discovery and development, Bio-physical properties, Property based drug design, drug design, Solid State properties, Solubility, Permeability, Lipophilicity, Physicochemical descriptors, High-Throughput Physicochemical Screens, Developability of molecules, Polymorphism, Discovery workflow

Chris Kresser is this weeks special guest. I have been a big fan of Chris's work for some time, blending nutrition and medical science together to help people on a very specific level. In this episode we talk about cholesterol & heart disease, gut permiability, strategise for optimal health, and then explore the reasons why he wrote his new book 'Your Personal Paleo Code'. You can grab a copy of the book at: http://personalpaleocode.com 

It's a gut and optimal health special today with guests Wilde Performance. Cliff and Martha share their stories on what got them so interested in the gut via their personal circumstances. We talk the gut, food, inflammation, probotics, symptoms, leaky gut, gut periability, and making yourself feel AWESOME. http://www.wildeperformance.com 

Timothy Johnson, Donald Cameron, and Gregory Moore collaborate to investigate the relationship between tree root growth, architecture, and surface infrastructure permeability. Learn about their results on this episode of Science of Arboriculture.

Larry Winter is the Deputy Director of the National Center for Atmospheric Research (NCAR). In that role he assists with scientific leadership, provides administrative oversight, and helps formulate strategic goals, budgets, and programmatic priorities for the institution. Dr. Winter is also an Adjunct Professor in the Department of Hydrology and Water Resources at the University of Arizona. Before moving to NCAR, Dr. Winter was leader of three groups at Los Alamos National Laboratory. During 1997-1999 he led the Computer Research and Applications Group; from 1995-1997 he led the Geoanalysis Group; from 1990-1995 he led the Applied Mathematics and Statistics Team. Presented March 23, 2012.

In this report, Apparent Permeability (Papp) and Efflux data demonstrate how an automated procedure, when compared to manual processing, provides a method that is less variable and is capable of delivering a more accurate assessment of a compound’s absorption characteristics.

Water is arguably the most important physical resource as it is the one that is essential to human survival. Understanding the global water cycle and how we use water is essential to planning a sustainable source of water for the future. In the UK there are areas where water supplies are limited, showin by recent droughts. Globally, there are many reas that do ot have enough water to support the current population adequately. Decisions will have to be made on the best way to use water in a world where there is climate change. This study unit is just one of many that can be found on LearningSpace, part of OpenLearn, a collection of open educational resources from The Open University. Published in ePub 2.0.1 format, some feature such as audio, video and linked PDF are not supported by all ePub readers.

Monica Vavilala, MD, discusses her recent article published in the May issue of Pediatric Critical Care Medicine.

Monica Vavilala, MD, discusses her recent article published in the May issue of Pediatric Critical Care Medicine.

Inhibition of Apolipoprotein-E signaling is a potential clinical strategy for enhancing the delivery of neuroprotective drugs to the brain after ischemic stroke.

In this first lecture on the theory of literature in social contexts, Professor Paul Fry examines the work of Mikhail Bakhtin and Hans Robert Jauss. The relation of their writing to formalist theory and the work of Barthes and Foucault is articulated. The dimensions of Bakhtin's heteroglossia, along with the idea of common language, are explored in detail through a close reading of the first sentence of Jane Austin's Pride and Prejudice. Jauss's study of the history of reception is explicated with reference to Borges' "Pierre Menard, Author of the Quixote" and the Broadway revival of Damn Yankees.

In this first lecture on the theory of literature in social contexts, Professor Paul Fry examines the work of Mikhail Bakhtin and Hans Robert Jauss. The relation of their writing to formalist theory and the work of Barthes and Foucault is articulated. The dimensions of Bakhtin's heteroglossia, along with the idea of common language, are explored in detail through a close reading of the first sentence of Jane Austin's Pride and Prejudice. Jauss's study of the history of reception is explicated with reference to Borges' "Pierre Menard, Author of the Quixote" and the Broadway revival of Damn Yankees.