Podcasts about Permeability

Interview with Rupert Verco, CEO, Cobra ResourcesOur previous interview: https://www.cruxinvestor.com/posts/cobra-resources-lsecobr-discovers-high-grade-copper-gold-over-74m-9534Recording date: 24th June 2026Cobra Resources is advancing what it describes as Australia's only rare earth project suited to in situ recovery (ISR), a mining method that offers lower capital costs, reduced environmental impact, and faster development timelines compared to conventional techniques. Located in South Australia, the project has recently confirmed mineralisation across two prospects through sonic core drilling, supporting progress toward a maiden mineral resource estimate.A defining feature of the project is its high-value rare earth composition. Approximately 43% of the mixed rare earth carbonate (MREC) basket consists of heavy rare earths, including nearly 5% dysprosium and terbium—elements critical for electric vehicles and wind turbines and typically more valuable than light rare earths. This positions Cobra competitively among global ionic clay projects.Technical results further support ISR viability. Permeability testing has demonstrated strong hydraulic connectivity, with transmissivity rates of around 8 metres per day and 80% tracer recovery within two days. These metrics suggest efficient leach cycles of 30–60 days and support well-field spacing that enhances operational efficiency. Importantly, high tracer recovery also indicates effective containment, a key requirement for regulatory approval.The project may also benefit from natural sulfide oxidation within the orebody, which can generate sulfuric acid in situ. This could offset a significant portion of reagent costs, typically around 30% of operating expenses in ISR projects, improving overall economics.Cobra plans a low-cost pilot study using existing infrastructure and ANSTO's facilities to validate the ISR process, followed by a scoping study. With supportive regulatory conditions in South Australia and proven ISR analogues in similar geological settings, the project presents a differentiated, capital-efficient pathway to rare earth production amid rising global demand for critical minerals.Learn more: https://www.cruxinvestor.com/companies/cobra-resourcesSign up for Crux Investor: https://cruxinvestor.com

Are your daily probiotics actually healing your gut, or are they just passing straight through your system? In this fascinating episode of Beauty Bytes, I am joined by clinical nutritionist Oscar Coetzee to discuss the massive paradigm shift happening in longevity medicine: cultivating powerful "Keystone" bacteria.Oscar explains why standard probiotics are like buying a bouquet of "cut flowers" that inevitably wilt, and introduces the revolutionary science behind anaerobic strains that actually plant themselves into your gut lining. We dive into the incredible benefits of Akkermansia, a bacteria that triggers your body's natural GLP-1 production, and uncover a specific microbe that produces endogenous salicylic acid to clear acne and rosacea from the inside out.If you want to understand the true gut-skin connection, this is a must-listen.

In this encore episode, we detail the structure of the intestinal mucosal barrier alongside central roles that zinc plays in supporting various aspects of mucosal barrier integrity. We discuss key anatomical features, including the mucus layer, epithelial cells, and tight junctions, as well as detail zinc's physiological roles, its relationship with copper, and factors that can affect zinc levels. The discussion further details zinc levels, zinc absorption, and specialized forms of zinc, such as zinc carnosine.Topics:1. Introduction - Overview of intestinal barrier anatomy- Highlighting the role of zinc 2. Intestinal Barrier Anatomy - Four major layers: mucosa, submucosa, muscularis externa, serosa- Mucosa subdivisions; focus on epithelium  3. The Mucus Layer  - Location over the epithelial surface- Composition: mucin-rich, secreted by goblet cells- Goblet cell mucin storage and expansion upon hydration- Functions: trapping pathogens, lubricating epithelium, housing molecules including secretory IgA- Small intestine mucus - Large intestine mucus 4. The Intestinal Epithelium - Monolayer of epithelial cells: enterocytes, goblet cells, and more- Tight junctions, paracellular transport - Continuous epithelial renewal 5. Introduction to Zinc - Zinc as a trace mineral required in minute quantities for numerous physiological processes - Second most abundant trace mineral after iron; majority stored in muscle and bone- Maintaining plasma and intracellular zinc concentrations within narrow range- Both deficiency and excess can disrupt biochemical processes 6. Zinc and Copper  - Zinc and copper as closely interconnected minerals- Zinc, copper, and metallothionein binding in enterocytes- Both high and low zinc can disrupt zinc-copper balance- Metallothionein as a cysteine-rich metal-binding protein  7. Factors Affecting Zinc Levels  - Multifactorial- Possible signs of low zinc status 8. Zinc Absorption  - Dietary sources- Primary absorption in small intestine - In the stomach: HCl and pepsin denature proteins and cleave peptide bonds, releasing zinc from protein complexes- Dietary zinc often bound within tertiary protein structure- Specialized transporters  9. Zinc's Role in the Intestinal Barrier  - Zinc and tight junction proteins- Zinc and Intestinal Epithelial Cells - Zinc and the mucus layer 10. Broader Context of Zinc in Physiology   11. Zinc Carnosine  - Molecular complex of zinc and carnosine- L-carnosine composed of beta-alanine and L-histidine- Gastrointestinal context 12. Conclusion - Multifactorial and multi-system.Thank you to our episode sponsor: 1. Shop Luxxe Red Light™ ⁠⁠here⁠⁠ and receive 10% off.* Luxxe Red Light™ panels are for general wellness and are not intended to diagnose, treat, cure, or prevent any disease. *This podcast is for general informational and educational purposes only and should not be used as medical advice. Thanks for tuning in!"⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

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TWiM explains how competition for nutrients anticipates and potentially mitigate drug side effects on the gut microbiota, and metabolic control of porin permeability influences antibiotic resistance. Become a patron of TWiM. Links for this episode: Nutrient competition predicts drug effects on microbiota (Cell) Metabolic control of porin permeability influences antibiotic resistance in E coli (Nat Micro) Santiago Cano-Muniz   Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv  

In this episode, Dr. Samuel B. Lee, MD sits down with Komala Lyra, international Tantra teacher and visionary guide, for an extraordinary conversation about spiritual permeability, radical self-trust, and the true essence of Tantra. From her intuitive departure from Brazil as a teenager to decades immersed in the wisdom of Osho and the sacred arts of Tantra, Komala's journey is a profound testament to living in surrender and listening deeply to the voice of the soul.Komala shares how the discipline of meditation, bodywork, and immersive community life sculpted her being into one of receptivity, presence, and courage. This episode dives deep into the essence of sacred sexuality, the redefinition of boundaries, and the alchemy of turning life into a living ritual. With poetic precision, Komala unveils what it means to live from the heart and honor the timing of life.Sacred Truths & Lessons from This Episode:• Permeability is the gateway to presence• Following the soul rarely makes sense to the mind• Spiritual maturity means embracing not knowing• True Tantra is a practice of inner aliveness, not performance• Boundaries dissolve when presence is strong• Real community starts with radical self-responsibilityTo learn more about Komala Lyra:

Permeability: It Can Be Your Superpower!  | Join The Conversation Call In at 323-524-2599

This Dhamma talk was offered on May 31, 2025 at Abhayagiri Buddhist Monastery.

The blood-brain barrier (BBB)

There's an ingredient that nobody's really talking much about that's being sneaked into our food and is eroding our first line of defense against all of the chronic diseases of aging.  The most likely things to take away our resilience or kill us early are metabolic dysfunction, cardiovascular disease, cancer, neurodegenerative disease and autoimmune diseases.  We have a built-in protective defense system, but it's getting literally dissolved away by this food ingredient.  Eliminating it will help you age at an elite level so you're capable of living more as you get older, rather than less.Come hang out with meSend me a message: healthcouragecollective@gmail.comTake My Udemy Course about The Basics of Female Bioidentical Hormone Replacement Therapy: 

US EPA's Office of Research and Development (ORD) is sponsoring a presentation on electrokinetic (EK)-enhanced in situ remediation technologies that are available for addressing contaminants in low-permeability (low-k) subsurface environments where conventional hydraulic delivery technologies often face challenges. The presentation introduces ORD's recently published Engineering Issue Paper (EIP) on the technology. The primary author will present on EK technologies and provide insights to the user community on ways to best utilize the EIP. ORD's EIPs are a series of technology transfer documents that summarize the latest information on selected waste treatment and site remediation technologies and related issues and present it in a conveniently accessible manner to the user community. EIPs are designed to help remedial project managers (RPMs), on-scene coordinators (OSCs), contractors, and other contaminated sites technical staff and site managers understand the type of data and site characteristics that are needed to evaluate a technology for a specific site, as well as ways to design and optimize a technology for a particular application. To view this archive online or download the slides associated with this seminar, please visit http://www.clu-in.org/conf/tio/Low-K-Enviro_092624/

US EPA's Office of Research and Development (ORD) is sponsoring a presentation on electrokinetic (EK)-enhanced in situ remediation technologies that are available for addressing contaminants in low-permeability (low-k) subsurface environments where conventional hydraulic delivery technologies often face challenges. The presentation introduces ORD's recently published Engineering Issue Paper (EIP) on the technology. The primary author will present on EK technologies and provide insights to the user community on ways to best utilize the EIP. ORD's EIPs are a series of technology transfer documents that summarize the latest information on selected waste treatment and site remediation technologies and related issues and present it in a conveniently accessible manner to the user community. EIPs are designed to help remedial project managers (RPMs), on-scene coordinators (OSCs), contractors, and other contaminated sites technical staff and site managers understand the type of data and site characteristics that are needed to evaluate a technology for a specific site, as well as ways to design and optimize a technology for a particular application. To view this archive online or download the slides associated with this seminar, please visit http://www.clu-in.org/conf/tio/Low-K-Enviro_092624/

This is a free preview of a paid episode. To hear more, visit smokeempodcast.substack.comNancy here. One of the super-cool things about being a journalist is that you can contact people whose work amazes you and say, “Come on my podcast!” and they almost always say, “Sure!”As did Michael Powell, one of my favorite journalists working today, currently at The Atlantic and previously at The New York Times, where, during the height of our national meltdown (aka 2020 to 2022), Michael took on subjects many of his colleagues and others in media would not touch: DEI, Title IX, and using identity as a scythe to cut down those deemed not the right color or gender or whose whose views were opportunistically seen as problematic. “We lost our bearings,” says Michael, who kept true to course, and to say his clear-eyed work made me feel less crazy is an understatement.Of deep value and delight is also his 2019 book, Canyon Dreams: A Basketball Season on the Navajo Nation. I felt as though I were living inside the work as I read, and I cannot wait to see Rez Ball, the movie it inspired and which opens September 27.Also discussed:* The explosive DNC protests that weren't* COVID would cool down the culture wars, right? [Insert laugh track here]* The “scurrilous piece of journalism” in the Daily Beast by a writer Nancy now admires** The firing of veteran New York Times science reporter Donald McNeil Jr.? “Not the best moment of the New York Times, at all.” * The tenderness and importance of Jihad Rehab (now retitled The UnRedacted) and the shame of Abigail Disney* “Hey Michael, you're white…”Plus, the permeability between worlds that you start to see when hanging in the Native world, the politician Michael always thought of as “a clown,” some high-tone hot boxes, and much more!Want to become a paid subscriber? Skoden!*Max Tani, now at SemaforCross-posted at Make More Pie

In this episode, we delve into the complexities of how Borrelia burgdorferi, the bacterium responsible for Lyme disease, impacts the brain, leading to neuroinflammation and a spectrum of neurological symptoms. We'll explore the pathophysiology of Borrelia's interaction with the brain's blood-brain barrier, its evasion of the immune system, and the direct effects on neural cells. Additionally, we'll discuss specific neurological symptoms and manifestations. Topics: 1. Introduction - Overview of Lyme disease and its causative agent, Borrelia burgdorferi. - Explanation of Borrelia's invasive nature and its ability to cross biological barriers like the blood-brain barrier (BBB). 2. Understanding the Blood-Brain Barrier (BBB) - Endothelial Cells: Primary cellular component of the BBB, unique to the brain for their tightly joined structure. - Astrocytes: - Role in regulating blood flow through neurovascular coupling. - Interaction with neurons and release of vasoactive substances. - Contribution to BBB integrity by influencing tight junction formation. - Pericytes: - Contribution to BBB permeability and regulation through contractile capabilities. 3. Sponsor Break: Daily Nouri 4. Pathophysiology of Borrelia in the Brain - Invasion Mechanisms: - Borrelia's ability to adhere to and invade endothelial cells. - Role of surface proteins and induction of matrix metalloproteinases (MMPs). - Immune Evasion and CNS Invasion: - Antigenic variation to avoid immune detection. - Triggering of immune responses within the CNS, involving microglia and peripheral immune cells. - Cytokine production and its consequences on neuronal health. 5. Direct Impact on Brain Cells - Neurons: Effects of Borrelia invasion on cellular functions, mitochondrial dysfunction, and apoptosis. - Astrocytes: Transition to reactive astrocytes in the presence of Borrelia and their role in neuroinflammation. - Oligodendrocytes: Impact on myelin production and implications for cognitive and motor functions. 6. Sponsor Break: AX3 Life 7. Neurological Symptoms and Manifestations - Symptoms Overview: Headaches, facial palsy, cognitive impairments, nerve root inflammation, POTS. - Psychiatric Manifestations: Potential psychological symptoms like depression and anxiety due to neuroinflammation. 8. Conclusion - Importance of addressing neurological symptoms of Lyme through a bioindividual and root-cause approach. - Recap of key points and reference to previous relevant episodes for further listening. Thank you to our episode sponsors: Check out Daily Nouri and use code CHLOE20 for 20% off your order. Check out ⁠AX3 Astaxanthin⁠ and use discount code ⁠CHLOE20⁠ for 20% off your first order. Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Emulsifiers are common in our diets, enhancing the texture, appearance and shelf life of many foods. But are they safe? In today's episode, Jonathan and Federica uncover the surprising truth about emulsifiers in our food. We learn the science behind emulsifiers, their impact on health, and the rising concerns over there extensive use in ultra-processed foods. Dr Federica Amati is a King's College London researcher and a registered nutritionist. She is also a lecturer and Nutrition Topic Lead at Imperial College School of Medicine. Federica empowers people with accessible, practical knowledge to make informed choices on diet and lifestyle and to improve health based on unique needs and preferences, at every stage of life. Learn how your body responds to food

Biomedical Engineer Margot Damaser meets Research Scientist Petra de Graaf and Pharmacologist Pradeep Tyagi to discuss their captivating ICS abstract presentations on urethral structure disease studied using a human urethra-on-a-chip and the interaction between perfusion and permeability in bladder inflammation.Human urethra-on-a-chip to study urethral sticture diseaseProbing The Interplay of Perfusion and Permeability in Bladder Inflammation Early registration for ICS 2024 Madrid is now open at www.ics.org/2024The ICS annual meeting is the must-attend, multidisciplinary event for clinical and research scientists interested in: Urology Urogynaecology Female and functional urology Gynaecology Bowel dysfunction Neurourology Pure and applied science Physiotherapy Nursing Geriatrics The ICS 2024 Madrid conference fosters collaboration between all disciplines involved in continence care.

Dr. Penner describes two primary factors of gut health to be absorption and barrier function or permeability. His lab's work on permeability is suggesting that intestinal regions really drive total gut permeability to a much greater extent than ruminal permeability in dairy cows. (7:06)Ms. Bertens is Dr. Penner's Ph.D. student and explains some new methodologies she developed for measuring gut permeability using chromium EDTA and cobalt EDTA. It's common to use an oral dose of chromium EDTA as a marker to measure total tract permeability. Claire's work, using cannulated cows, used a ruminal dose of chromium EDTA for total tract permeability and an abomasal dose of cobalt EDTA for post-ruminal permeability. Both of these markers are indigestible, non-metabolizable and have no transcellular transport mechanisms. Claire is working to publish the new method as a complete validation study has been completed. (9:15)While this method is currently limited to using cannulated animals, Greg and Claire could envision a less sophisticated and more applied on-farm technique to assess permeability. Until then, there are still a lot of management observations that can identify potential issues with gut permeability. The appearance of feces and the presence of mucin casts can both be indicative of gut issues. Certainly dry matter intake is a major influencer on gut health, and Claire also sees potential in new technologies like rumination collars or rumination ear tags. (13:47)Are there certain time points in a dairy cow's life when she is at risk for increased gut permeability? Dr. Penner describes research suggesting if weaning is implemented too abruptly, that really increases the risk for decreased barrier function of the gut. Erratic feed intake patterns resulting from withholding feed for any reason at any age can also increase the risk of leaky gut. For example, depressed intake during the transition phase, along with anything that drives a response through an underlying systemic inflammatory response, probably creates risky situations for leaky gut. Claire is currently running a study looking at the impacts of intramammary LPS infusion on gut function. Greg envisions that learning more about gut function could create a new philosophy for treating sick animals. In the past, only antimicrobials were used to treat mastitis, but now it's common to also treat with a NSAID for pain. Perhaps in the future, we will also provide treatment to accelerate the recovery of the gut to prevent secondary disorders. (16:15)How long does an off-feed event have to last to cause an issue in the gut? It seems a fairly acute time period is all that is needed. Most studies are trying to replicate what happens on-farm, for example during mastitis, heat stress or the transition period. Greg indicates that not only will permeability be impacted, but ruminal absorptive capacity can also decline rapidly in these conditions. In Claire's LPS challenge study, cows' rectal temperatures peak around six hours after the LPS infusion and usually resolve within 12 hours. But most cows do not eat for a solid 12 hours during the challenge, and they are slow to recover feed intake over the next few days. In cows that aren't sick but experience feed restriction in experimental protocols, they tend to overeat when they are allotted the full ration and this can lead to ruminal acidosis. (21:57)Increased incidences of liver abscesses in beef-on-dairy calves are being reported in the industry. Dr. Penner speculates that perhaps these calves are not always achieving adequate passive transfer, and may not be receiving high enough levels of milk replacer to support a more robust immune system. It may be the increased beef cattle genetics in the calves are putting an added requirement on growth or muscle development that may not be met by lower levels of milk replacer or even lower colostrum feeding levels. (34:40)In closing, providing cows with a consistent environment where they can meet their needs by their own behavior such as free access to feed when hungry and to a comfortable stall when it's time to rest. Cows reward consistency with health and production. Gut health in a commercial setting is a relevant issue and it might go undiagnosed or undetected. Research into where in the gut permeability is occurring will help define strategies to modulate response. While off-feed events for individual animals might be harder to recognize in a large dairy environment, new technology may allow for earlier diagnosis. (40:43)Please subscribe and share with your industry friends to bring more people to join us around the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll get a shirt in the mail to you.

There's still a lot we don't understand about the science of leaky gut. Does it cause disease or is it a symptom? What's the best way to test for it? Which treatments actually work to repair it?  Today's guest is one of the best people to begin to answer these questions.  Dr. Camilleri is a renowned gastroenterology researcher and professor at the Mayo Clinic.  Tune in to hear about cutting-edge innovations and informed understandings around leaky gut testing and treatment.  If you have any additional questions you would like answered in the future, let me know in the comments!   Watch/Read Next… What is Leaky Gut: https://drruscio.com/what-is-leaky-gut/  Leaky Gut Suplements: https://drruscio.com/leaky-gut-supplements/  Probiotics for Stomach Issues: https://drruscio.com/probiotics-for-stomach  Learn more about Dr. Camilleri's work: https://www.mayo.edu/research/faculty/camilleri-michael-m-d-d-sc/bio-00026245    Timestamps 00:00 Intro  03:25 Dr. Camilleri's background with leaky gut 05:05 Bile-acid supplementation  07:20 The small intestine  11:07 The prevalence of leaky gut  14:25 Leaky gut & diseases 20:08 Leaky gut & inflammation 30:18 Treatment: Where to start  36:09 Biomarkers of leaky gut 48:53 Leaky gut testing  53:24 Gluten intolerance prevalence  59:52 Food elimination & reintroduction  01:04:47 Prebiotics & FODMAPs 01:15:26 Probiotics   Featured Studies  What to do about the leaky gut: https://pubmed.ncbi.nlm.nih.gov/34509978/ Leaky gut: mechanisms, measurement and clinical implications in humans: https://pubmed.ncbi.nlm.nih.gov/31076401/ Development and Validation of Test for "Leaky Gut" Small Intestinal and Colonic Permeability Using Sugars in Healthy Adults: https://pubmed.ncbi.nlm.nih.gov/33865841/  A case for improved assessment of gut permeability: a meta-analysis quantifying the lactulose:mannitol ratio in coeliac and Crohn's disease: https://pubmed.ncbi.nlm.nih.gov/35012471/  Food Emulsifiers and Metabolic Syndrome: The Role of the Gut Microbiota: https://pubmed.ncbi.nlm.nih.gov/35892789/ Food Additive Emulsifiers and Their Impact on Gut Microbiome, Permeability, and Inflammation: Mechanistic Insights in Inflammatory Bowel Disease: https://pubmed.ncbi.nlm.nih.gov/33336247/ Serum zonulin and its diagnostic performance in non-coeliac gluten sensitivity: https://pubmed.ncbi.nlm.nih.gov/32060130/ Psychological and Gastrointestinal Symptoms of Patients with Irritable Bowel Syndrome Undergoing a Low-FODMAP Diet: The Role of the Intestinal Barrier: https://pubmed.ncbi.nlm.nih.gov/34371976/  Probiotics fortify intestinal barrier function: a systematic review and meta-analysis of randomized trials: https://pubmed.ncbi.nlm.nih.gov/37168869/  Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome: https://pubmed.ncbi.nlm.nih.gov/30108163/    Get the Latest Updates Facebook - https://www.facebook.com/DrRusciodc Instagram - https://www.instagram.com/drrusciodc/ Pinterest - https://www.pinterest.com/drmichaelrusciodc    DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment. Music featured in this video: "Modern Technology" by Andrew G, https://audiojungle.net/user/andrew_g  *Full transcript available on YouTube by clicking the “Show transcript” button on the bottom right of the video.

Building upon our previous discussion on optimizing the cortisol awakening response (ep. 89) for more productive mornings, we now shift our focus to the vital role of mitochondria in enhancing our energy and productivity in the new year. We'll explore the intricate structures within mitochondria, the mechanisms leading to dysfunction, and most importantly, uncover effective strategies, including supplements and dietary choices, to optimize mitochondrial function. Topics: 1. Introduction to Mitochondrial Dysfunction and Energy Production - Overview of optimizing natural energy levels - Factors leading to mitochondrial dysfunction and FATIGUE 2. Understanding Mitochondrial Structures - Outer membrane - Permeability and function - Intermembrane space - Role in proton gradient - Inner membrane - Cristae and its significance - Matrix - Krebs cycle and NADH generation - Mitochondrial DNA and ribosomes 3. Mechanisms of Mitochondrial Dysfunction - Loss of inner mitochondrial membrane potential - Alterations in the electron transport chain - Reduced transport of critical metabolites 4. Ways to Improve Mitochondrial Function - Preface for non-root cause issues - Factors causing mitochondrial damage - Example of ROS impact on ATP production 5. Supplements for Enhancing Mitochondrial Function - Alpha lipoic acid - Role in increasing glutathione levels - L-carnitine - Fatty acid transport and mitochondrial function - Use in weight loss - CoQ10 - Involvement in the electron transport chain - Mitochondrial membrane phospholipids - Lipid replacement therapy for repairing damage already done 6. Essential Minerals and Micronutrient Blood Panel - Importance of essential minerals in mitochondrial metabolism - The need for micronutrient blood panel 7. NAD+ and NADH - Importance in the electron transport chain - Precursors like NMN and NR for optimization 8. Other Modalities for Mitochondrial Support - Mention of red light therapy - Emphasis on dietary choices and antioxidant intake - Importance of structural repair with lipid replacement therapy 9. Additional Tools and Research - Urolithin A for stimulating mitochondrial recycling process Thanks for tuning in! ⁠⁠⁠⁠⁠Book An Intro Coaching Call with Chloe Porter⁠⁠⁠⁠⁠ Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok ⁠⁠⁠⁠⁠@chloe_c_porter⁠⁠⁠⁠⁠ Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

It's a wrap! The Spotify variety, if you know what I mean... This year I thought it would be fun to do a live "unwrapping" of the Podcasters Wrapped, which provides fun information and insights about your podcast (those that use Spotify are oh so familiar with this fun annual event!). I found it amazing and hysterical that The Red Light Report community has nearly identical tastes to me, both in regards to  top podcast genres listened to and top music genres listened to. I have no doubt we could all get along!   On a more mitochondrial note, I found a highly interesting research article on methylene blue and its potential as an anti-aging drug. To a large degree, this should come as no surprise given methylene blue's immense and dynamic impact on the mitochondria and, as we all know, the inherent tie our mitochondria's health and function has on our overall welling and lifespan. The review discusses the anti-aging effects of MB with a focus on the relationship between mitochondrial dysfunction and aging.The article did a fantastic job of verifying this by looking at the profound role "the blue" can play on the aging brain, particularly those neurodegenerative conditions we associate with our latter years -- Alzheimer's disease and Parkinson's disease. From the article: "​Since MB is an FDA-approved medicine with a long history, the safety of MB usage has been thoroughly evaluated. The exploration of MB utilization in aging-related conditions can help us understand the aging process. Derivatives of MB can also be developed to improve its effects."Could methylene blue be one of the most effective (while still being incredibly safe) anti-aging drugs ​known to mankind? The jury is out, but the current data is quite strong. Let's not forget it's remarkable synergism with red light therapy...​​ As always, light up your health! - Key points Introduction, Holiday Greetings, and Spotify 2023 Wrapped (00:00:00 - 00:16:41) Additional Avenues for Red Light Therapy, Mitochondrial Health, and Methylene Blue (00:16:41 - 00:17:08) Article Introduction on Methylene Blue as an Anti-Aging Drug (00:17:09 - 00:17:34) Free Radicals Theory of Aging and Mitochondrial Health (00:17:35 - 00:23:36): 00:20:35 - 00:26:36 Methylene Blue as an Anti-Aging Drug (00:23:37 - 00:24:39): 00:26:37 - 00:27:39 Synergistic Effects of Red Light Therapy and Methylene Blue (00:24:40 - 00:25:39): 00:27:40 - 00:28:39 Methylene Blue's Permeability, Historical Uses, and Applications (00:25:39 - 00:26:49): 00:28:39 - 00:29:49 French Study on Methylene Blue and Potential Antiviral Effects (00:26:49 - 00:28:03): 00:29:49 - 00:31:03 Dosages, Safety, and Benefits of Methylene Blue (00:28:03 - 00:29:58): 00:31:03 - 00:32:58 Recommendations and Personal Example (00:29:58 - 00:32:35): 00:32:58 - 00:35:35 Ongoing Benefits, Comparisons to Red Light Therapy (00:32:35 - 00:33:54): 00:35:35 - 00:36:54 Applications Section - Methylene Blue in Brain Aging (00:33:54 - 00:35:09): 00:36:54 - 00:38:09 Methylene Blue's Impact on Mitochondrial Function and Brain Diseases (00:35:09 - 00:37:43): 00:38:09 - 00:40:43 Role in Alzheimer's and Parkinson's Diseases (00:37:44 - 00:41:23): 00:40:44 - 00:44:23 Memory Enhancement and Benefits in Treating Brain Aging (00:41:23 - 00:43:12): 00:44:23 - 00:46:12 Summarizes Importance of Methylene Blue in Mitochondrial Health (00:43:46 - 00:46:47): 00:46:46 - 00:49:47 Potential Derivatives, Broader Implications (00:46:47 - 00:47:36): 00:49:47 - 00:50:36 Pervasive Role of Mitochondria, Simple Health Improvement Strategies (00:47:36 - 00:49:24): 00:50:36 - 00:52:24 Encouragement for Ratings and Reviews (00:49:44 - 00:49:48): 00:52:44 - 00:52:48 Conclusion - Wishing Listeners an Amazing Week and Prioritizing Health (00:49:48 - End) - Learn more about methylene blue & BioBlue: Methylene blue​ ​BioBlue - Dr. Mike's #1 recommendations: Grounding products: Earthing.com EMF-mitigating products: Somavedic Blue light blocking glasses: Ra Optics - To learn more about red light therapy, methylene blue, and shop for the highest-quality red light therapy products, visit https://www.biolight.shop - Stay up-to-date on social media: Dr. Mike Belkowski: Instagram LinkedIn   BioLight: Instagram YouTube Facebook

Timestamps & Summary Dr. Greg Eckerle (01:24)Do we normally call that intestinal acidosis outside of the agricultural university complex?Dr. Greg PennerI think probably the most common term that's used is hindgut acidosis rather than intestinal acidosis. And it probably makes sense given where we think most of that fermentation activity would occur and where the primary reduction in PH would be localized.Dr. Greg Eckerle (02:02)What can we do with the hindgut intestinal acidosis? And how is that having an impact?Dr. Greg PennerFirst of all, one of the things we need to recognize is rumen acidosis and hindgut acidosis often occur simultaneously. And in fact, we probably should reclassify ruminal acidosis to lumenal, so that it encompasses a broader area of the gastrointestinal tract. You're right, from a challenge or mitigating response, it's not easy to deliver compounds that are going to be released to buffer in the large intestine. So, we're really needing to focus more on strategies that promote ruminal digestion efficiently while minimizing or managing the risk of fermentable materials that reach the large intestine.Dr. Greg Eckerle (05:19)Is there any sort of mitigation practices that we could utilize to help keep that intestinal junction and intestinal villi healthy?Dr. Greg PennerCertainly, our data as well as others have shown that if PH is too low for too long, again, we don't have good thresholds characterized for the hindgut, but we do see a leaky gut, or at least increased permeability of the gut. Our work has been able to show that both outside of the animal using ex vivo conditions and also inside the animal using in vivo markers, we actually see greater permeability responses in post-ruminal regions rather than the ruminal region. […]Dr. Greg Eckerle (08:27)What can we utilize and look at when we see animals undergoing a medicinal acid challenge?Dr. Greg PennerI think it's really hard to differentiate ruminal acidosis and hindgut acidosis. And as I mentioned earlier, they often occur simultaneously. I think in many cases, we've looked at indicators of hindgut acidosis as evidence for ruminal acidosis. And so we've probably been looking at it backward. […]Dr. Greg Eckerle (11:56)Do we see an alteration in more pathogenic bacteria or harmful bacteria to the animal which could lead to increased ailments, transition of other things that enterotoxins, and things like that?Dr. Greg PennerThere was some nice work done by Dr. Kees Plaizier at the University of Manitoba where they did some grain versus alfalfa induction protocols for ruminal acidosis. And fortunately, they have both ruminal microbial changes. And in some of those studies, they also have hindgut microbial changes. And if I recall right, I believe E. Coli abundance, I think they stopped at a genre level, but E. Coli abundance was increased. And so certainly we get concerned about E. Coli from a potential contaminant of meat or meat products and not something we want to increase concentration of, recognizing not all E. Coli will be harmful or truly pathogenic. […]Dr. Greg Eckerle (13:48)When we look at the terminal carcass evaluation of these animals, do we see an increase in liver abscess scores from Fusobacterium that may cross this damaged intestinal?Dr. Greg PennerThat's a great question, and that's the hypothesis we have. But unfortunately, I have not seen any data that confirms whether fusobacterium is crossing the rumen, crossing regions of the intestine, or both. […]Dr. Greg Eckerle (16:15)Are there certain production periods for either both beef and dairy that we need to be paying more attention to with those management practices to help reduce those risks?Dr. Greg PennerLet's start on the dairy side. I think probably the greatest risk factor is early in the transition phase. And the reason I say that is there's a number of changes that have likely occurred during that time. […]In terms of feedlot cattle, I think any factor, again, that leads to a reduction in feed intake, even a transient reduction, probably increases risk for rumen and hindgut acidosis. So, these could be things like respiratory disease, it could be heat stress events, they could be transportation events. […]Dr. Greg Eckerle (21:52)What would be three of the main take-home messages that we have for nutritionists, veterinarians, and producers when we want to help mitigate or strategize systems on farms?Dr. Greg PennerI think the first one is […] that what happens in the rumen influences the more distal parts of the gastrointestinal tract. […]The second one is when we look at the responsiveness of the intestinal regions, they're probably regions that are more prone to leakiness. […]The third one goes back to good standard practices, and I think this will never be eliminated from core tasks or core skills of a nutritionist bunk calling. […]

Leaky gut, LPS, and exciting research about your microbiome and how to heal your gut – and thereby your entire body. Leaky gut is the number one driving factor behind morbidity and mortality worldwide. But this interview delivers information on how to heal. Research shows that you can reduce leaky gut and its inflammatory effects by 70-90% in just 30 days. Listen to how in this episode.Kiran is an internationally well-known research … läs mer Inlägget 341b: Kiran Krishnan – Leaky gut. Get healthy by healing gut permeability (English) publicerades först på 4Health.se by Anna Sparre. Inlägget 341b: Kiran Krishnan – Leaky gut. Get healthy by healing gut permeability (English) dök först upp på 4Health.se by Anna Sparre.

Today's episode dives into a not-so-well-known oral peptide supplement, formerly called AT-1001, and now referred to as larazotide acetate. We go over what this peptide does within the gut, how it blocks zonulin receptors, where to get it, why it's not well-known, and so much more! Truly, the research is pretty incredible and intriguing, so stay tuned... because this peptide could very well be the next game-changing supplement for "leaky gut!" Topics: 1. Discussion on Anti-Zonulin Peptide Compound - Introduction to the topic 2. The Gut Lining's Structure and Composition - Villi and Microvilli: Enhancing Surface Area - The presence and importance of crypts - Monolayer of epithelial cells explained 3. Different Types of Cells in the Gut Lining - Enterocytes: Absorption of Nutrients - Goblet Cells: Mucus Secretion - Paneth Cells: Antibacterial Function - M Cells: Immune Surveillance - Enteroendocrine Cells: Hormone Secretion - Stem Cells: Renewal and Replenishment 4. Tight Junctions: Ensuring Gut Integrity - Definition and importance of tight junctions - Components of tight junctions: Claudins, Occludin, JAMs - Interaction with the cytoskeleton through ZO proteins - Dynamic regulation in response to various conditions 5. Zonulin's Role in Intestinal Permeability - Gliadin's interaction with enterocytes leading to zonulin release - Zonulin's impact on the cytoskeleton and, therefore, tight junctions - Gliadin peptides' interaction with immune cells and celiac disease 6. Other Factors Influencing Zonulin Release and Gut Integrity - List of factors that directly or indirectly affect gut integrity 7. Larazotide Acetate: A Novel Peptide Compound - Definition and mechanism of action - Real-world implications and studies 8. Current State and Future of Larazotide Acetate - Studies and their discontinuation? - Its emergence in peptide supplement companies - The importance of consulting with medical professionals Thanks so much for tuning in! Order Chloe's Book "⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠" TODAY! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.28.551049v1?rss=1 Authors: Keshavanarayana, P., Spill, F. Abstract: The inner lining of blood vessels, the endothelium, is made up of endothelial cells. Vascular endothelial (VE)-cadherin protein forms a bond with VE-cadherin from neighbouring cells (homophilic bond) to determine the size of gaps between the cells and thereby regulate the size of particles that can cross the endothelium. Chemical cues such as Thrombin, along with mechanical properties of the cell and extracellular matrix (ECM) are known to affect the permeability of endothelial cells. Abnormal permeability is found in patients suffering from diseases including cardiovascular diseases, cancer, and COVID-19. Even though some of the regulatory mechanisms affecting endothelial permeability are well studied, details of how several mechanical and chemical stimuli acting simultaneously affect endothelial permeability are not yet understood. In this article, we present a continuum-level mechanical modelling framework to study the highly dynamic nature of the VE-cadherin bonds. Taking inspiration from the catch-slip behaviour that VE-cadherin complexes are known to exhibit, we model VE-cadherin homophilic bond as cohesive contact with damage following a traction-separation law. We explicitly model the actin-cytoskeleton, and substrate to study their role in permeability. Our studies show that mechano-chemical coupling is necessary to simulate the influence of the mechanical properties of the substrate on permeability. Simulations show that shear between cells is responsible for the variation in permeability between bicellular and tri-cellular junctions, explaining the phenotypic differences observed in experiments. An increase in the magnitude of traction force that endothelial cells experience results in increased permeability, and it is found that the effect is higher on stiffer ECM. Finally, we show that the cylindrical monolayer exhibits higher permeability than the planar monolayer under unconstrained cases. Thus, we present a contact mechanics-based mechano-chemical model to investigate the variation in permeability of endothelial monolayer due to multiple loads acting simultaneously. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Rob and Ryan watched and break down Season 2, Episode 14 of the Big Bang Theory: The Financial Permeability!**GIVE US A 5 STAR REVIEW ON APPLE PODCASTS AND BE ENTERED IN TO WIN A $100 GIFT CARD TO AMAZON! BETTER LISTEN TO THE EPISODE FOR DETAILS! https://podcasts.apple.com/us/podcast/theoretical-nonsense-the-big-bang-theory-watch-a/id162307941400:00:00 - Intro, emails, neighbor update00:11:21 - Recap Begins00:20:00 - Snack Wars! Twizzlers vs Redvines & Icees vs Slurpies 00:31:18 - What are the most popular movie theater snacks, ranked!  00:46:56 - What's an epaulet? and what's the deal with berets? 01:03:15 - Finding the endurance to succeed01:13:26 - What's makes someone a professional?01:16:33 - What is the penalty for public urination in CaliforniaFind us everywhere at: https://linktr.ee/theoreticalnonsense~~*CLICK THE LINK TO SEE OUR IQ POINT HISTORY TOO! *~~-------------------------------------------------Welcome to Theoretical Nonsense! If you're looking for a Big Bang Theory rewatch podcast blended with How Stuff Works, this is the podcast for you!  Hang out with Rob and Ryan where they watch each episode of The Big Bang Theory and break it down scene by scene, and fact by fact, and no spoilers! Ever wonder if the random information Sheldon says is true? We do the research and find out! Is curry a natural laxative, what's the story behind going postal, are fish night lights real? Watch the show with us every other week and join in on the discussion! Email us at theoreticalnonsensepod@gmail.com and we'll read your letter to us on the show! Even if it's bad! :) If you need any artwork done for you, check out johnkimdesigns.comMusic by Alex Grohl. Find official podcast on Apple, Stitcher, and Spotify https://podcasts.apple.com/us/podcast/theoretical-nonsense-the-big-bang-theory-watch-a/id1623079414

Struggling with Celiac Disease, leaky gut, food sensitivities or bodywide complaints that you think may originate in your gut? Explore strategies to individualize your diet to attain a healthy and diverse gut microbiome. Also, learn about critical food preparation steps for legumes to minimize gut damage with Vincent Pedre, MD. Lindsey Parsons, your host, helps clients solve gut issues and reverse autoimmune disease naturally. Take her quiz to see which stool or functional medicine test will help you find out what's wrong. She's a Certified Health Coach at High Desert Health in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on Facebook, Tiktok, Twitter, Instagram or Pinterest or reach her via email at lindsey@highdeserthealthcoaching.com to set up a free 30-minute Gut Healing Breakthrough Session. Show Notes

This episode is brought to you by Cozy Earth, BiOptimizers Magnesium Breakthrough, and Levels. Today on The Dhru Purohit Podcast, Dhru sits down with Dr. Akil Palanisamy to discuss why there's been such an explosion in autoimmune disease and how certain insults in our modern-day society—like heavy metals, pesticides, poor diet, and chronic stress—could be to blame. Dr. Akil is a renowned Integrative Medicine practitioner who combines conventional medicine with holistic approaches like Functional Medicine and Ayurveda. He is a Harvard graduate and received his MD from the University of California, San Francisco. Dr. Akil completed his residency training at Stanford University and a fellowship in Integrative Medicine with Dr. Andrew Weil at the University of Arizona. He has authored two books, The Paleovedic Diet and The TIGER Protocol which is set to be released on May 9th. In this episode, Dhru and Dr. Akil dive into:-The recent explosion in autoimmune disease (2:26)-Top toxins that contribute to autoimmunity (6:26)-How to combat toxin exposure using lifestyle (22:12)-Conventional treatments for autoimmune disease (34:08)-Why autoimmune conditions develop (39:23)-Case example of people at high risk for autoimmunity (1:11:00)-Dr. Akil's two-phase diet recommendations for autoimmune disease (1:21:30)-Blood tests and symptoms to detect early stages of autoimmunity (1:32:33)-Foods central to repairing the gut (1:37:22)-The carnivore diet for autoimmunity explained (1:48:36)-Ancient Ayurvedic principles we can apply to our modern lifestyle (2:01:33)-The importance of rest and mindset in autoimmunity (2:13:46)Also mentioned in this episode:-Dr. Akil's clinic, Sutter Health-The Paleovedic Diet-Preorder Dr. Akil's new book, The TIGER Protocol here. For more on Dr. Akil Palanisamy, check out his website, doctorakil.com. Cozy Earth are the most comfortable, temperature-regulating, and nontoxic sheets on the market. Right now, get 40% off your Cozy Earth sheets. Just head over to cozyearth.com and use code DHRU.Right now, you can get 10% off Sleep Breakthrough. And if you buy two or more you'll get a free bottle of Magnesium Breakthrough. This is a limited-time offer! So just go to sleepbreakthrough.com/dhru and use code dhru10.By leveraging biosensors like continuous glucose monitors (CGMs), Levels provides real-time feedback on how diet and lifestyle choices impact your metabolic health. Right now, Levels is offering my listeners two free months of their Levels Membership. Head on over to levels.link/DHRU to learn more. Hosted on Acast. See acast.com/privacy for more information.

Blog summary of an Editorial was published in Oncotarget, entitled, “Permeability and driving force: why is it difficult to control glycolytic flux by blocking lactate transporters?“ _________________________________ The process of glycolysis, or the conversion of glucose to energy in cells, is a critical component of many biological processes. This process is highly regulated, and glycolytic flux has been implicated in a variety of disease states, including cancer and diabetes. Despite significant advances in our understanding of glycolysis, researchers continue to find it difficult to control glycolytic flux. “Overall, glycolysis facilitates tumour proliferation and survival, and has become a hotly-pursued target for therapeutic inhibition.” In a new editorial paper, researchers Wiktoria Blaszczak and Pawel Swietach from the University of Oxford explored the challenges of this issue and potential solutions. On January 26, 2023, their editorial was published in Oncotarget and entitled, “Permeability and driving force: why is it difficult to control glycolytic flux by blocking lactate transporters?“ “In our recent study (Blaszczak et al. (2022)), using a panel of pancreatic ductal adenocarcinoma cell lines, we characterised how extracellular acidity feeds back to inhibit further glycolytic acid production [6].” Full blog - https://www.oncotarget.org/2023/02/16/controlling-glycolytic-flux-therapy-challenges-and-solutions/ DOI - https://doi.org/10.18632/oncotarget.28351 (PDF Download) Correspondence to - Wiktoria Blaszczak - wiktoria.blaszczak@dpag.ox.ac.uk Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28351 Keywords - MCT inhibitors, fermentative metabolism, lactate, PDAC, SLC16A1 About Oncotarget Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form, and then quickly released to Pubmed. On September 15, 2022, Oncotarget was accepted again for indexing by MEDLINE. Oncotarget is now indexed by Medline/PubMed and PMC/PubMed. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/OncotargetYouTube LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

In this podcast Kate Allen and Laura Fitzharris are talking about 'Training the equine respiratory muscles: Inspiratory muscle strength' and Wendy Pearson discusses 'The combination of trailer transport and exercise increases gastrointestinal permeability and markers of systemic inflammation in horses'.

The symptoms of ADHD can be exacerbated by inflammatory foods such as gluten, dairy and soy. Learn from Dana Kay, Board-Certified Holistic Health and Nutrition Practitioner, about the effects inflammatory foods have on ADHD and what supplements can help reduce the symptoms of ADHD. Lindsey Parsons, your host, helps clients solve gut issues and reverse autoimmune disease naturally. Take her quiz to see which stool or functional medicine test will help you find out what's wrong. She's a Certified Health Coach at High Desert Health in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on Facebook, Twitter, Instagram or Pinterest or reach her via email at lindsey@highdeserthealthcoaching.com to set up a free 30-minute Gut Healing Breakthrough Session. Show Notes

*Plasma vs Dark Matter: While old earth secular scientists continue to search for “dark matter” to rescue their failing Big Bang cosmology, friend of RSR Joe Spears joins Fred and his co-host Doug McBurney to look further into the Setterfield Plasma Cosmology. *Godspeed: Fred and Joe discuss why light may have traveled faster in the past, and why it may very well be slowing down. Also see Fred & Doug's previous show back in March 2022 on how the fix is in for speed of light measurements. *Quantized Red Shift Explained: Hear how the observed data regarding the red shift reveals the likelihood of an electromagnetic creation week more so than a gravitational 13.549567 Bn Years. Plasma cosmology also removes the need to explain red shifts via an expanding universe, which is a better fit for scripture given that God said He "stretched the heavens", past tense! *Permittivity and Permeability: Einstein described the speed of light in a vacuum as a constant. But Fred Williams has observed the slowing of the speed of light personally! We know that light travels more slowly through a medium. Hear how the “fabric” of the universe may impact the speed of light. *The Big Stretch: Thus says God the LORD, Who created the heavens and stretched them out, Who spread forth the earth and that which comes from it, Who gives breath to the people on it, And spirit to those who walk on it: “I, the LORD, have called You in righteousness, And will hold Your hand; - Is 42: 5-6. Hear what this stretching may have involved, preserving the conservation of energy, while allowing distant starlight visible from the earth in less than 10,000 years.

*Plasma vs Dark Matter: While old earth secular scientists continue to search for “dark matter” to rescue their failing Big Bang cosmology, friend of RSR Joe Spears joins Fred and his co-host Doug McBurney to look further into the Setterfield Plasma Cosmology. *Godspeed: Fred and Joe discuss why light may have traveled faster in the past, and why it may very well be slowing down. Also see Fred & Doug's previous show back in March 2022 on how the fix is in for speed of light measurements. *Quantized Red Shift Explained: Hear how the observed data regarding the red shift reveals the likelihood of an electromagnetic creation week more so than a gravitational 13.549567 Bn Years. Plasma cosmology also removes the need to explain red shifts via an expanding universe, which is a better fit for scripture given that God said He "stretched the heavens", past tense! *Permittivity and Permeability: Einstein described the speed of light in a vacuum as a constant. But Fred Williams has observed the slowing of the speed of light personally! We know that light travels more slowly through a medium. Hear how the “fabric” of the universe may impact the speed of light. *The Big Stretch: Thus says God the LORD, Who created the heavens and stretched them out, Who spread forth the earth and that which comes from it, Who gives breath to the people on it, And spirit to those who walk on it: “I, the LORD, have called You in righteousness, And will hold Your hand; - Is 42: 5-6. Hear what this stretching may have involved, preserving the conservation of energy, while allowing distant starlight visible from the earth in less than 10,000 years.

Dr. Linda Chu discusses COVID vaccine-associated myocarditis with Dr. Kate Hanneman. "Myocardial Injury Pattern at MRI in COVID-19 Vaccine-associated Myocarditis". Myocardial Injury Pattern at MRI in COVID-19 Vaccine–associated Myocarditis. Fronza et al. Radiology 2022; 304:553–562. Dr. Nikita Consul's Radiology In Training article summary "Choroid Plexus Volume and Permeability at Brain MRI within the Alzheimer Disease Clinical Spectrum". Choroid Plexus Volume and Permeability at Brain MRI within the Alzheimer Disease Clinical Spectrum. Choi et al. Radiology 2022; 304:635–645. 

Join Fazale “Fuz” Rana and Jeff Zweerink as they discuss new discoveries taking place at the frontiers of science that have theological and philosophical implications, as well as new discoveries that point to the reality of God's existence. Cell membranes are incredibly complex biochemical suprasystems composed of hundreds of different types of lipids. Is there any rhyme or reason to the compositional makeup of cell membranes or do they merely reflect the outworking of historically contingent evolution? In this episode, Fuz Rana discusses a recent study that reveals the rationale for the compositional complexity of cell membranes, highlighting that these systems display an organization and compositional fine-tuning that can be marshaled to make a case for intelligent design. The standard model of particle physics stands as an incredibly robust model of the universe with great explanatory power. Yet scientists know it is incomplete. New measurements of the W boson mass might provide clues about how to extend the standard model. Will the new measurements hold up under further scrutiny? Will they provide ways to explain dark matter and other holes in the standard model? In this episode Fuz and Jeff discuss these important topics. References: “Membrane Thickness, Lipid Phase and Sterol Type Are Determining Factors in the Permeability of Membranes to Small Solutes,” https://doi.org/10.1038/s41467-022-29272-x Jacopo Frallicciardi, et al. (article)  “High-Precision Measurement of the W Boson Mass with the CDF II Detector,” https://www.science.org/doi/10.1126/science.abk1781 CDF Collaboration, T Aaltonen, et al. (article) Additional Resources: “Bringing Order to the Case for Intelligent Design, Part 1,” https://reasons.org/explore/publications/articles/bringing-order-to-the-case-for-intelligent-design-part-1, Fazale Rana (blog) “Biotic Borders: Cell Membranes under Scrutiny,” https://reasons.org/explore/publications/facts-for-faith/biotic-borders-cell-membranes-under-scrutiny, Fazale Rana (blog)

this sunday read-aloud is a child of the second episode of the journal of small work*, pattern language + permeability. it is concerned particularly with our permeable selves, and our bigger selves, the one that encompasses a whole earth system in perpetual exchange. this tiny piece touches on the exchanging of the possibly toxic for the definitely edible, accepting our microbial-ness, looking to the cycling of this living being we are living within for patterns that lead us to better decisions. all of that. it would be lovely to hear what you think of it. and if you missed a link i posted yesterday to a new interview with sophie from big things little things, you might like to listen in about just these sorts of concerns and approaches.with thanks to the appleturnover radio and film patrons. you make this possible. i like to think of it as a csa, like my regenerative-agrarian friends cultivate; community supported activism. thank you. follow appleturnover on patreon for more. Hosted on Acast. See acast.com/privacy for more information.

Have you heard of leaky gut? Do you know what it means to have leaky gut? Is it something that applies to you? What is it that leaks from the gut? Why would your gut become leaky, and why would it matter? Is there anything you can do about it? How many people in the western world are affected by increased intestinal permeability?Autoimmune study: https://www.ahajournals.org/doi/abs/10.1161/circ.137.suppl_1.p238Links to supplements mentioned (not affiliate links!)Ion (formerly called restore): https://zachbushmd.com/ion/Leptin Shield:https://gundrymd.com/supplements/lectin-shield/GI Integrity:https://www.pureencapsulationspro.com/g-i-integrity.htmlGI Fortify:https://www.pureencapsulationspro.com/g-i-fortify.htmlFree resources:Free Virtue Meditation: healthcourage.ck.page/meditation Guide to be ready before you get sick: https://healthcourage.ck.pageMP3 Audio of empowering questions to reprogram your subconscious: https://healthcourage.ck.page/questions

With Mud Talks 15-3 we continue a special eight-part miniseries dedicated to the topic of preserving earthen architecture. In this third episode of the series we speak to Pat Taylor, Historic Preservation Specialist & General Contractor followed by Eric Liefeld, President of Mesilla Valley Preservation, Inc. We speak about capillary action, permeability and salt attack – including sources, processes and effects of deterioration.Resources & Further Reading:Adobe Conservation - A Preservation Handbook pp. 51 to 56by Cornerstones Community Partnerships (Author), Francisco Uviña Contreras (Illustrator)Publisher: Sunstone Press (August 15, 2006)ISBN-13: 978-0865345270https://www.cstones.org/booksPozzolans for Lime Mortarsby Pat Gibbonshttps://www.buildingconservation.com/articles/pozzo/lime-pozzolans.htmHot Mixed Lime & Traditional Mortars: A Practical Guide to Their Use in Conservation and Repairby Nigel Copsey (Autor) Publisher: The Crowood Press Ltd (July 1, 2019)ISBN-13: 978-1785005558Mesilla Valley Preservation, Inc. Websitehttp://mvpres.orgSalts of the Earth: When Salts Attack!https://youtu.be/ntPbiZOnpGgThe Mud Talks Preserving Earthen Architecture series is brought to you in collaboration with Cornerstones Community Partnerships and is made possible by the support of the US Department of the Interior, National Park Service and a National Center for Preservation Technology & Training grant.

"There once was a brave lad named Leonard. With a fi-fi fiddle dee-dee. He faced a fearsome giant. While Raj just wanted to pee."Our episode discussion includes Red Vines vs Twizzlers, the relatability of both the cold open and Penny's financial issues, how society judges people who are poor, viewing scenes through our Leonard/Penny goggles, and more!Download hereRunning time: 1:04:40, 44.5 MB

If you've ever wondered whether or not bread is healthy, you've come to the right place. Bread comes in so many shapes and sizes, and ever since the whole keto diet trend came about, it's been touted as one of the worst foods out there. But is that true? In this episode, I'll break down: - whether or not bread is actually bad for you - the ins and outs of celiac disease - what it means to be non-celiac gluten sensitive - if whole grain bread is really better for you than white - how to beat the food guilt when it comes to bread ... and more! Show Notes: Otto's Cassava Flour - my favorite GF flour for making your own bread at home! Spectrum of gluten-related disorders: consensus on new nomenclature and classification Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease Effect of Gliadin on Permeability of Intestinal Biopsy Explants from Celiac Disease Patients and Patients with Non-Celiac Gluten Sensitivity Phytic Acid: From Antinutritional to Multiple Protection Factor of Organic Systems Whole Grains, Dietary Fibers and the Human Gut Microbiota: A Systematic Review of Existing Literature Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: systematic review and dose-response meta-analysis of prospective studies You can learn more about me by following on IG @imperfectlypaigewellness or by checking out my blog, freebies, and offers on my website: https://imperfectlypaigewellness.com Please share with #PaigeTalksWellness to help get the word out about the show - and join the Imperfect Health Fam over on Facebook.

Abundance, Manifesting and Time are themes in this channeled message just in time for the New Moon. Archangel Michael says “Contemplate the ways in which you serve humanity, the ways in which you serve yourself, and the ways in which you protect yourself.”“As you shine your light into darkness it supports everyone. Time is not limited to right now. Fully trust the permeability of time...Your message carries the strength of your awareness. Inside you is a fountain of wisdom, the wisdom of consciousness that flows through… As consciousness flows through you, you flow through consciousness As you flow through consciousness, it pours forth in everything that you say and do… And when you just take a moment to connect a little deeper and listen for more guidance, you might learn something about the bigger picture that just wasn't apparent before. When you connect to this bigger picture, you fall into the arms of grace.”Fall Specials - I offer Psychic Readings, Custom Paintings, Healy Frequencies, Reiki, Reiki Trainings, and Animal Readings. Fall specials include: Custom Paintings are half off at $450, Healy Frequencies are $50, and Animal Readings start at $75. Visit: SarahRossiter.com/sessionsRate and Review Giveaway - I'm offering a free registration to my course Creativity and Consciousness that starts on Oct 1. This is a $1299 value. Or you can choose to receive an original painting by me and a 30 minute psychic reading. A value of $1100. On iTunes you can rate this podcast and write a review - take a screenshot and send it to me and you will be entered to win. This month the drawing is going to be on the full moon of Sept 20. Send your review screenshot to: bookings@thepsychicartistpodcast.comAnd thank you for your support, it means so much to me and helps to share this podcast with a larger audience.Two Free Online Presentations in September:Money and Creativity with Brad Yates - Friday, September 10 at 12pm PST/3pm EST. We will be tapping on allowing more money for creative people. Join live: Facebook.com/TapWithBradHeal, Clear, and Release to Improve Your Creativity with Rebecca Packard and Marisa Imon - Friday September 24 at 9am HST/12pm PST/3pm EST. We will talk about how to heal trauma, clear energy, and release anything not supporting your creative process. This opens you up to manifesting more abundance and ease in your life and work. Find out more at: SarahRossiter.com/trainingsCreativity and Consciousness - Allow the bright and light energy of creative fire to flow through you. Are you ready to make the work that has been calling to you? Join this 10 week interactive live video course and connect to your creative source. Tap into consciousness and find your authentic voice, through any creative medium. Guest speakers include Author Mark Gober, Creative Entrepreneur Laura Michelle Powers, Tapping Expert Brad Yates, Emotion Code Practitioner Rebecca Packard, Singer/Songwriter Marisa Imon, and Intuitive Shelley Wasicki-Franke. Starting October 1st on Fridays at 9am HST/12pm PST/3pm EST. Payment plans are available, for as low as a $111 a month. Sarah Rossiter is an artist, writer and psychic medium.Website: SarahRossiter.comInstagram: SRossiterStudioFacebook: The Psychic Artist PodcastEmail: bookings@thepsychicartistpodcast.comThanks for listening to The Psychic Artist Podcast. If you've enjoyed this episode, please leave a review and share!

Periods of chronic stress can precede gut problems and often be their cause or a major contributing factor. Learn about the physiological mechanisms involved in stress-induced gastrointestinal issues or flares of existing problems like diarrhea, constipation, acid reflux, SIBO, candida, dysbiosis, leaky gut, IBS and IBD and ways to combat and reduce chronic stress for better gut health. Lindsey Parsons, your host, helps clients solve gut issues and reverse autoimmune disease naturally. She's a Certified Health Coach at High Desert Health in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on Facebook, Twitter, Instagram or Pinterest or reach her via email at lindsey@highdeserthealthcoaching.com to set up a free 30-minute Gut Healing Breakthrough Session or a 1-hour initial consultation. Show Notes

Light cannot be anything but a longitudinal disturbance of the AETHER. Light can be nothing else but a sound in the AETHER. Like a vocal frequency propagation. Not through the medium, OF AND WITHIN THE MEDIUM!

Light cannot be anything but a longitudinal disturbance of the AETHER. Light can be nothing else but a sound in the AETHER. Like a vocal frequency propagation. Not through the medium, OF AND WITHIN THE MEDIUM!

Autoimmune disease often starts in the gut. In fact, intestinal permeability is believed to be a necessary precursor to autoimmune disease. In this interview with Dr. Drew Sinatra, a naturopath from Northern California and co-host of the podcast “Be Healthistic”, we talk about what the research says about the gut microbiome in autoimmune disease, his approach to treating autoimmunity and immune-supportive supplements, as well as his approach to treating Epstein-Barr virus, SIBO, candida and much more. Lindsey Parsons, your host, helps clients solve gut issues, reverse autoimmune disease and type 2 diabetes naturally and lose weight without cutting calories or cutting out major food groups. She's a Certified Health Coach at High Desert Health in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on Facebook, Twitter, Instagram or Pinterest or reach her via email at lindsey@highdeserthealthcoaching.com to set up a free 1-hour Healthy and Sustainable Weight Loss/Health Restoration Breakthrough Session. Show Notes

Chronic diarrhea, constipation, gas or bloating; arthritis or joint pain; nutritional deficiencies; autoimmune disease; headaches; brain fog; memory loss; excessive fatigue; skin rashes; acne; eczema or rosacea; cravings for sugar or carbs? You may have leaky gut or intestinal permeability. Learn about what it is, why it happens and how to fix it with Certified Health Coach Lindsey Parsons, EdD. Show Notes

Learn about the most common parasites found in stool samples in the U.S., why parasite testing through your doctor will likely miss parasites you may have, symptoms of a parasite infestation, treatment options, and how to get testing for parasites and candida via ParaWellness Research with Dr. Raphael d'Angelo, MD. Lindsey Parsons, EdD, the host, helps clients solve gut issues, reverse autoimmune disease and type 2 diabetes naturally and lose weight without cutting calories or cutting out major food groups. She's a Certified Health Coach at High Desert Health in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on Facebook, Twitter, Instagram or Pinterest or reach her via email at lindsey@highdeserthealthcoaching.com to set up a free 1-hour Healthy and Sustainable Weight Loss/Health Restoration Breakthrough Session. ParaWellness Research: http://parawellnessresearch.com Keto Kube bread from Uprising Foods: https://www.uprisingfood.com/ Lindsey Parsons' Fullscript Dispensary: https://us.fullscript.com/welcome/highdeserthealth Functional Health and Nutrition Review with Lindsey: http://highdeserthealthcoaching.com/functional-health-and-nutrition-review/ Health Coaching Breakthrough Session with Lindsey: http://highdeserthealthcoaching.com/healthcoaching/ Lindsey's Gut Healing Facebook Group: https://www.facebook.com/groups/gut.healing.for.you/ Lindsey's Healthy and Sustainable Weight Loss Tucson Facebook Group: https://www.facebook.com/groups/614864552264400/ Tucson Reversing Autoimmune Disease Together Meetup: https://www.meetup.com/Tucson-paleo-Meetup-Group/ Links to Lindsey's affiliate shops, lab tests and recommended products: http://highdeserthealthcoaching.com/supplements-and-lab-tests/ Lindsey Parsons' web site: High Desert Health: http://highdeserthealthcoaching.com and email: lindsey@highdeserthealthcoaching.com High Desert Health on Facebook: https://www.facebook.com/HighDesertHealth/ High Desert Health on Instagram: https://www.instagram.com/high.desert.health/ or @high.desert.health High Desert Health on Twitter: https://twitter.com/HDesertHealth or @HDesertHealth High Desert Health on Pinterest: https://www.pinterest.com/highdeserthealth/ Credits:   Thank you to SoundDot for the music on the podcast: Royalty Free Music: www.soundotcom.com

Organic whole grains are better, no sprouted grains are better no avoid grains all together for the best health. Which is it? Confused about what gluten is and what it really does to your body? Have you noticed gut issues, skin rashes or puffy eyes a few days after eating a pastry, bread, cereal or crackers? Have you been to Europe or heard from friends that gluten grains are no problem for them over there? What if your issues aren't from wheat at all but a combination of toxins affecting the gut lining? Doc J breaks down how the mix of gluten rich grains, pesticide rich foods, food additives and alcohol affect the body and why it may be the source of your health issues. What You'll Learn In Today's Episode: Why it's more than just wheat to blame for gut, skin and mood issues Why Einkorn wheat is easier to digest How processed foods, food additives, alcohol and pesticides combine in your gut to cause intestinal permeability What to do to keep your gut lining healthy and maybe be able to eat wheat again

Are you avoiding sugar but drinking diet soda and making low carb sweet treats with sugar substitutes?  Depending on your use of artificial sweeteners you might be doing more harm that good in your quest to avoid sugar or stick with your low carb diet.  Research has shown that consumption of artificial sweeteners, including some processed forms of stevia can irritate your gut lining and kill your good gut bacteria.  In this episode Doc J discusses what's in these artificial sweeteners that are irritating your gut, killing your good bacteria and causing leaky gut symptoms.

Basics The blood brain barrier is the last layer of cells between what's in your blood and the extracellular fluid around your brain cells. You're born with it!  It's main job is filtration. 2 ways things get through the blood brain barrier: Passive diffusion: small, neutral molecules (water, gases, lipid-soluble) Active transport: glucose, amino acids, drugs (like a revolving door) Permeability: how easily something can pass through a layer without work Things that change permeability: Inflammation - stretches layer and makes holes bigger (meningitis, injury) Multiple sclerosis - an auto-immune disease that can degrade the BBB Alzheimer's - BBB becomes overwhelmed with antibodies and burns out *Scary Section* Rabies is a virus that is small and can get through the blood brain barrier but the immune system cells, antibodies from the vaccine, and medicines can't. HIV encephalopathy is caused when a mutation of the HIV gets into the brain and use brain cells to replicate (rather than the well-known T-cells of the immune system).  There is also a rare symptom of HIV called HIV-associated dementia. Callback microchimerisms - Pregnancy causes the permeability of many areas of the body to change, and this includes the BBB. Test Yourself Drugs that have central nervous system effects (good) or side effects (bad) cross the BBB.  See what you know of different medications and what job they're supposed to do and what negative side effects they cause and see if you can guess if they cross the BBB. Connect with me Support us on Patreon *NEW* Join the Pharmacist Answers Podcast Community on Facebook Subscribe: iTunes, Stitcher, GooglePlay, TuneIn Radio Like the Facebook page Music Credits:  “Radio Martini” Kevin MacLeod (incompetech.com)  Licensed under Creative Commons: By Attribution 3.0  http://creativecommons.org/licenses/by/3.0/

Leaky gut is a concept that the cells of our gut lining are inflamed from the foods we eat, environmental toxins, stress as well as hormonal and nutrient deficiencies. Leaky gut gets it's namesake as molecules of food, viruses, bacteria, fungal organisms, medications and environmental toxins that should stay in the digestive system to be eliminated end up passing through “leaks” in the gut lining to the blood stream. Once these molecules end up in the blood stream the body sees them as foreign molecules and goes to attack them. The body's overactive immune system response causes a host of issues from muscle & joint pain to skin rashes, hives, acne, headaches and brain fog along with multiple food sensitivities.