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In dieser Folge von Darf's ein bisschen Chemie sein? dreht sich alles um freie Radikale und ihre Gegenspieler, die Antioxidantien. Wir klären, was freie Radikale chemisch gesehen sind, wie sie in deinem Körper Schäden anrichten und welche molekularen Mechanismen hinter ihrer Neutralisation stecken. Dabei werfen wir einen detaillierten Blick auf Vitamin C, Vitamin E und Glutathion und erklären, warum Antioxidantien so wichtig für unsere Gesundheit sind. Außerdem: Wie entstehen eigentlich freie Radikale durch UV-Strahlung, und was passiert dabei auf molekularer Ebene? Freu dich auf eine spannende Reise in die Welt der Biochemie und erfahre, wie Antioxidantien den oxidativen Stress in deinem Körper bekämpfen. Außerdem: am Ende gibt es ein kleines Schmankerl zu meiner Forschung :) Informationen zum Podcast Recherche und Skript: Anne Mayer, mit Unterstützung von ChatGPT 4o Ton und Schnitt: Anne Mayer
Brigitte Brisson, DMV, DVSc, DACVS from the Ontario Veterinary College at the University of Guelph joined us on OsteoBites to introduce Magnetic Resonance guided High Intensity Focused Ultrasound as a treatment modality for osteosarcoma and describe preliminary results in canine patients.High Intensity focused ultrasound (HIFU) is a non-invasive percutaneous thermal ablation technique that allows deep tissue treatment with precise control over the shape and location of energy deposition. It causes minimal collateral damage and can be used to treat primary and metastatic tumours. In addition to its role in tumour ablation, HIFU has attracted attention for its potential to stimulate the immune system and possibly mount a response against metastasis. In humans, HIFU has been used for ablation of a variety of soft tissue tumours and most recently, it has been used in bone applications, specifically for the treatment of osteoid osteoma (OO) lesions in pediatric patients. Other reported bone applications include bone metastasis and osteosarcoma.Dr. Brigitte Brisson is a professor of soft tissue surgery in the Department of Clinical Studies at the Ontario Veterinary College (OVC). She graduated from the Faculté de Médecine Vétérinaire at the University of Montreal in 1996. She performed a small animal rotating internship at the OVC followed by a Surgery residency with concurrent Doctor of Veterinary Science (DVSc) in small animal surgery. She became board certified in small animal surgery (ACVS) in 2001 and has since been on faculty at the Ontario Veterinary College. She is an ACVS Founding Fellow in Minimally Invasive Surgery and a Founding Member of Veterinary Neurosurgical Society.
In this episode, Peter Bandettini hosts Jon Polimeni, Renzo Huber, Nikola Stikov, Luca Vizioli, and Essa Yacoub. They talk about the International Society for Magnetic Resonance in Medicine (ISMRM) and Organization for Human Brain Mapping (OHBM) conferences where they have attended both over many years. The conversation revolves around what each meeting offers, how they differ, how we might increase cross-talk, and why that would be a good thing. They also highlight some of the exciting work and developments gleaned from ISMRM that might not appear at OHBM. Enjoy! This is the final episode of Neurosalience Season 4! See you in the next season :) Episode producers: Omer Faruk Gulban
Safety First: Caring for Patients in a Perioperative Magnetic Resonance Area by AORNJournal
Dr. Nicolene Shields has spent her career helping children reach their potential. From her first days as a hospital intern psychologist through to leading her own unique specialised practice, Nicolene has 8 years of experience working with families. Nicolene is a certified Behavioural Neuroscientist, Counsellor, Specialist Teacher & Clinical Neuropsychotherapist. A doting mum to her beautiful son, Nicolene is enthusiastic about sharing her proven and practical advice to uplift the lives of families in Australia and around the world. Dr. Nicolene's expertise speaks for itself: Bachelor of Arts in Psychology Bachelor of Social Science in Psychology (with Honours) Master of Counselling and Psychotherapy Master of Education and Cognitive Psychology Master of Special Education (Sensory Disabilities) Master of Neuroscience Graduate Certificate in Magnetic Resonance and Positron Emission Tomography Doctor of Philosophy (Neuropsychology) Brainwise Academy is the brainchild of Aussie mum and experienced Behavioural Neuroscientist, Counsellor, Specialist Teacher, and Clinical Neuropsychotherapist Dr Nicolene Shields. Nicolene aims to be the go-to solution for parents and education professionals who feel overwhelmed, burnt out and are struggling to cope with daily behavioural challenges. Who simply yearn to understand their children … better. Through our one-of-a-kind, high-quality online learning courses, Nicolene teaches you child development tools for life. That's right, life. Backed by science and real-world ready, our programs help you find your version of long-lasting life change for a happier, more harmonious life. For you, for your child, for the whole family. Dr. Nicolene Helps parents to understand :about the brain and how it develops; how to respond and nurture change in children; what practical tools to try at home or in the classroom. Learn more about Brainwise at https://www.brainwise.au/parent-courses This website link offers parents clear and specific information about the courses they can undertake to support them specifically with concerns relating to their children. The courses are of three categories that parents can elect to address issues in shorter- versus- longer and more intense courses.
Commentary by Dr. Candice Silversides
Commentary by Dr. Candice Silversides
In this episode, host, Geoffrey Rubin, MD, MBA, FACR, talks with Vivian S. Lee, MD, PhD, MBA, Executive Fellow and Senior Lecturer at Harvard Medical School. A radiologist and researcher, Dr. Lee recently served as President and Founder of Verily Health Platforms, where she helped build multiple successful start-ups, CEO of the University of Utah's Health System and Dean of the School of Medicine, as well as Chief Scientific Officer, and Senior Vice President of the New York University Langone Medical Center. Dr. Lee grew up in Norman, Oklahoma, the home of the University of Oklahoma, which ended up shaping the course of her career. A magna cum laude graduate of Harvard, Dr. Lee received a D.Phil in medical engineering from Oxford as a Rhodes Scholar, earned her MD with honors from Harvard, and her MBA from NYU. She was named one of the 100 Most Influential People by Modern Healthcare in 2022 for the third consecutive year and is the author of the widely acclaimed book, the Long Fix: Solving America's Health Care Crisis with Strategies that Work for Everyone. A Past President of the International Society for Magnetic Resonance in Medicine, Rhodes Scholar and member of the National Academy of Medicine, Dr. Lee is a health care executive dedicated to improving health and tackling climate change. You won't want to miss this inspiring conversation with a truly transformational leader.
With Pranav Bhagirath, Amsterdam University Medical Centre, Amsterdam - Netherlands & Helmut Puererfellner, Ordensklinikum Linz Elisabethinen, Linz - Austria. Link to editorial Link to paper
This time on Naked Neuroscience, James Tytko explores the miracle of magnetic resonance imaging (MRI) with Stephanie Brown from the University of Cambridge, including a new innovation to decrease 'scan-xiety' amongst children. Then, we'll be investigating the complexities of the current youth mental health crisis, with the help of Susanne Schweizer and Camilla Nord... Like this podcast? Please help us by supporting the Naked Scientists
Commentary by Dr. Valentin Fuster
Commentary by Dr. Valentin Fuster
Pregnant Personnel In The Magnetic Resonance Environment by AORNJournal
Patients With Tattoos In The Magnetic Resonance Environment by AORNJournal
Pregnant Personnel In The Magnetic Resonance Environment by AORNJournal
Patients With Tattoos In The Magnetic Resonance Environment by AORNJournal
This month we scope out endoscopes with Hannah and Kris from VESCO. From big to small, rigid and flexible, tune in to get the inside view on how to get the most out of your scope, and top tips for looking after it!
No episódio de hoje, tivemos uma conversa com Alessandro André Mazzola, físico e especialista na área de ressonância magnética. Alessandro compartilhou percepções sobre o campo da Física Médica, a história da ressonância magnética e suas contribuições significativas para os avanços na neurociência. Entre outros tópicos discutidos, mergulhamos em um entendimento detalhado de como a máquina de ressonância magnética funciona dentro dos princípios da física quântica, o que ela é capaz de detectar e os métodos usados para diferenciar os tipos de tecidos. Além disso, exploramos a importância dos cuidados com o paciente e os protocolos que devem ser seguidos para garantir a segurança de todos os indivíduos envolvidos no processo. Alessandro André Mazzola é bacharel e licenciado em Física pela PUC do Rio Grande do Sul e mestre em Ciências Radiológicas pela Universidade Federal do Rio de Janeiro. Especialista em Física do Radiodiagnóstico pela ABFM e em Ciências Radiológicas pela UFRGS. Sócio Efetivo da International Society for Magnetic Resonance in Medicine (ISMRM). Fundador e Diretor do MRIONLINE. Tem experiência na área de Física, com ênfase em Métodos de Diagnóstico por Imagem, atuando principalmente em Imagem por ressonância magnética. ----------- REFERÊNCIAS DO EPISÓDIO ---------- MRIONLINE - Website MRIONLINE - Youtube MRIONLINE - Instagram MRI Spins - Blog (site) The Basics of MRI (site) Questions and Answers in MRI (site) MRI Safety (artigo) Ressonância magnética: princípios de formação da imagem e aplicações em imagem funcional (artigo) Protocolo de testes de aceitação em equipamentos de imagem por ressonância magnética (artigo) Segurança em Imagem por Ressonância Magnética (livro) Ressonância Magnética Aplicações Práticas (livro) Handbook of MRI Pulse Sequences ------------------ Apoie o Canal! ------------ Contribuição mensal: apoia.se/podcastuniversogeneralista PIX: universogeneralista@gmail.com ------------------ Nossas Redes ------------------ YouTube - Instagram - Twitter -------- Tratamento de áudio ----------- Allan Spirandelli: Instagram - Spotify --- Send in a voice message: https://podcasters.spotify.com/pod/show/universogeneralista/message
What exactly is an MRI scan? Is there actually a magnet uses? What does resonance have to do with it? Listen to this podcast and find out how magnets and resonance are used to image our bodies.
This month we are joined by the wonderful Sally Griffin, European specialist in diagnostic imaging, who holds particular interest and expertise in ultrasonography of cats. From anatomy and approach, to sizes and sampling, listen in on our conversation around the particulars of feline ultrasonography. Whether you have scanned a cat or not, tune into this podcast today and challenge yourself to do more, or have a go!
With Perry Elliott & Athanasios Bakalakos, University College London, London (United Kingdom of Great Britain & Northern Ireland) Link to paper Link to editorial
Known to many as The Vet on the Coast 19, for his superb educational content and showcasing the best of Northern Ireland's coastline. Adam Conn, is an experienced farm animal vet specialising in dairy herd health and is an IMV imaging brand ambassador. Listen in as we discuss the newest technology coming to the EasiScan Go, the use of doppler ultrasound to help identify empty cows sooner and how we can use that information to reduce returns. The clinical team also discuss other uses for the EasiScan Go when out on farm, whether it's survey thoracic scanning for pneumonia in calves, or as a rapid patient side diagnostic tool for confirming limb fractures in larger patients, it really highlights the versatility of this ultrasound machine. So tune in, to find out more.
This month, IMV imaging's Focal Point has a new host as it teams up with the Vet Times Podcast to bring you some insights and initiative to the veterinary sector. We'll be discussing the results from the IMV-run survey on some of the challenges facing the veterinary industry of today and what's on the horizon to look forward to. Special guests include Christy Lightly, head of marketing for IMV-imaging, BVA president Malcolm Morley and Senior Vice-President for Northern Ireland Veterinary Association, Fiona McFarland.
This month the IMV clinical team welcome Becky Keeble MRCVS to the podcast. Becky is an experienced veterinary surgeon in laparoscopy, having performed over a 1000 procedures and is the co-founder of Simply Keyhole, a laparoscopy service providing veterinary practices with all the advice and training they need to start their own laparoscopy service. During the podcast we discuss the benefits, complication rates and myths surrounding laparoscopic ovariohysterectomies, so tune in to learn more!
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.29.534678v1?rss=1 Authors: Sirucek, L., Zoelch, N., Schweinhardt, P. Abstract: Purpose: Functional understanding of the periaqueductal grey (PAG), a physiologically and clinically highly relevant brainstem region, can be advanced using proton magnetic resonance spectroscopy (1H-MRS). However, the PAG's small size and high levels of physiological noise are methodologically challenging. This study aimed to (1) improve 1H-MRS data quality in the PAG using spectral registration for frequency and phase error correction, (2) investigate whether spectral registration is particularly useful in cases of greater head motion and (3) examine two metabolite quantification approaches using literature-based or individual-based water relaxation times. Methods: Spectra were acquired in 33 healthy volunteers (50.1 years, SD=17.19, 18 females) on a 3T Philipps MR system using a point-resolved spectroscopy sequence optimized with very selective saturation pulses (OVERPRESS) and voxel-based flip angle calibration (effective volume of interest size: 8.8x10.2x12.2 mm3). Results: Spectral registration significantly improved signal-to-noise ratios (SNR; p=0.048, median value [interquartile range]: 18.0 [17.00-20.00]) and spectral linewidth (N-acetylaspartate peak: p less than 0.001, 4.3 Hz [3.96-4.85]), as well as metabolite fit (p's less than 0.046) compared to post-processing with minimal frequency alignment using interleaved unsuppressed water peaks. Correlational analyses revealed smaller improvements in SNR in cases of greater head motion (p=0.002) recorded with a markerless motion tracking system. Metabolite concentrations were higher when quantified using individual-based compared to literature-based water relaxation times (p's less than 0.001). Conclusion: This study demonstrates that high-quality 1H-MRS can be acquired in the PAG using spectral registration. This offers new opportunities for future 1H-MRS studies in the PAG and possibly also other clinically relevant brain regions with similar methodological challenges. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
This month the clinical team discusses the role of the Veterinary Radiographer. Joined by both Bethany, our clinical radiographer, and Sam Kolodziejczak, a radiographer at Burgess Diagnostics, we delve into the need for radiographers within the veterinary profession, their role within an imaging team and how they have adapted since transferring over from the NHS. If you're a radiographer looking to make the jump or a veterinary nurse interested about their role, then tune in and learn the wonders of being a Veterinary Radiographer!
Commentary by Dr. Valentin Fuster
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.23.529659v1?rss=1 Authors: Shahid, S. S., Gregory, G., Brady, A., Yu-Chien, W. Abstract: Methadone-based treatment for pregnant women with opioid use disorder is quite prevalent in the clinical environment. A number of clinical and animal model-based studies have reported cognitive deficits in infants prenatally exposed to methadone-based opioid treatments. However, the long-term impact of prenatal opioid exposure (POE) on pathophysiological mechanisms that govern neurodevelopmental impairment is not well understood. Using a translationally relevant mouse model of prenatal methadone exposure (PME), the aim of this study is to investigate the role of cerebral biochemistry and its possible association with regional microstructural organization in PME offspring. To understand these effects, 8-week-old male offspring with PME (n=7) and prenatal saline exposure (PSE) (n=7) were scanned in vivo on 9.4 Tesla small animal scanner. Single voxel proton magnetic resonance spectroscopy (1H-MRS) was performed in the right dorsal striatum (RDS) region using a short echo time (TE) Stimulated Echo Acquisition Method (STEAM) sequence. Neurometabolite spectra from the RDS was first corrected for tissue T1 relaxation and then absolute quantification was performed using the unsuppressed water spectra. High-resolution in vivo diffusion MRI (dMRI) for region of interest (ROI) based microstructural quantification was also performed using a multi-shell dMRI sequence. Cerebral microstructure was characterized using diffusion tensor imaging (DTI) and Bingham-neurite orientation dispersion and density imaging (Bingham-NODDI). MRS results in the RDS showed significant decrease in N-acetyl aspartate (NAA), taurine (tau), glutathione (GSH), total creatine (tCr) and glutamate (Glu) concentration levels in PME, compared to PSE group. In the same RDS region, mean orientation dispersion index (ODI) and intracellular volume fraction (VFIC) demonstrated positive associations with tCr in PME group. ODI also exhibited significant positive association with Glu levels in PME offspring. Significant reduction in major neurotransmitter metabolites and energy metabolism along with strong association between the neurometabolites and perturbed regional microstructural complexity suggest a possible impaired neuroadaptation trajectory in PME offspring which could be persistent even into late adolescence and early adulthood. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
For børn og unge med OCD er kognitiv adfærdsterapi standardbehandlingen, men op mod halvdelen oplever ringe eller ingen effekt, og det er svært at forudsige, hvem der får gavn af behandlingen. Et nyt studie vil forsøge at bidrage med lille en brik til puslespillet. Svaret kan vise sig at ligge årtier ude i fremtiden, men forskningen er i gang.Det kan du høre om i den seneste udgave af podcasten Videnskabens Veje, hvor vi taler med Valdemar Uhre, psykolog og ph.d. ved Region Hovedstadens Psykiatri og Danish Research Centre for Magnetic Resonance.
This month, the IMV imaging Clinical Team are getting to the root of diagnostic imaging in Dentistry with, European Specialist in Small Animal Dentistry, Ingrid Tundo. From the importance of the techniques commonly used to how often should we be brushing our pet's teeth, if you have any dental related questions they are sure to be answered in this month's episode, so tune in!
With Bernhard Gerber, Université Catholique de Louvain, Brussels - Belgium & Varnavas Varnavas, Cliniques Universitaires St Luc UClouvain, Brussels - Belgium Link to editorial Link to paper
In this month's episode, we are keeping it short and sweet as the clinical team reflect back on the year and chat through their most memorable moments of 2022. We discuss the newest diagnostic imaging technologies and how they are revolutionizing the way we diagnose clinical cases. As always, there'll be topic related jokes as well as a few festive fails the clinical team are willing to share.
Welcome to this month's episode of Focal Point where we welcome Pete Lockwood to the podcast. Pete is a vet and is responsible for cardiac applications within IMV imaging. With this in mind we are discussing all things Doppler Ultrasound, from what it is to how we can apply it to our patients in practice. Whether you are starting to dip a toe in Doppler or are on course for shunt hunting, we break it down and decipher exactly what you need to know, with of course some doppler related fun thrown into the mix.
The discovery of resting state fMRI ushered in an entirely new subfield of fMRI and a new era in functional imaging that permeates much of what we do today. Today's guest, Professor Bharat Biswal is credited with the discovery of this signal. In this conversation Professor Biswal recounts the events leading up to and including his discovery of the resting state signal. He and Peter also talk about all things resting state fMRI, including white matter correlations and potential clinical applications. He even turns the tables on Peter, and asks a few questions of his own. This is worth a listen as he weighs in on the challenges, limits, and opportunities of resting state fMRI today. Today's Guest: Bharat Biswal, Ph.D. is Distinguished Professor in the Department of Biomedical Engineering at the New Jersey Institute of Technology. He is also affiliated with the Department of Radiology in New Jersey Medical School. He received his B.S. in Engineering from Uktal University in 1989, his M.S. from Michigan Technical University in 1991, and his Ph.D. from the Medical College of Wisconsin Department of Biophysics in 1996 under the mentorship of Jim Hyde. While in graduate school, Dr Biswal was the first to report the observation of functional correlation in the resting state signal - in this case between the left and right motor cortex. This first resting state fMRI paper was published in Magnetic Resonance in Medicine in 1995 and is titled: Functional Connectivity in the motor cortex of resting human brain using echo-planar MRI. Episode producers: Ekaterina Dobryakova Alfie Wearn Brain Art Artist: Paola Galdi Title: Yarn Brain Author Description: “I created this figure to debug a piece of code I was writing to map cortical vertices to volumetric voxels and count how many direct neighbours fell within a cortical ribbon mask. My code was definitely wrong, but the figure was cool!” Please send any feedback, guest suggestions, or ideas to ohbm.comcom@gmail.com
With Chiara Bucciarelli-Ducci (Interwiee), Royal Brompton and Harefield Hospitals, London - United Kingdom & Jessica Artico (Interwier), University College of London and Barts Heart Centre, London - United Kingdom. In this podcast, Prof Chiara Bucciarelli-Ducci, interviewed by Dr Jessica Artico, will discuss the enhanced role of Cardiovascular Magnetic Resonance in Heart Failure Patients and in the new HF guidelines. It will walk us through the advancements of this imaging technique, what can possibly change after the results of recent HF trials, as well as the role of stress CMR and the future perspectives of CMR for a HF specialist.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.13.512064v1?rss=1 Authors: Shamaei, A., Starcukova, J., Starcuk, Z. Abstract: Purpose: While the recommended analysis method for magnetic resonance spectroscopy data is linear combination model (LCM) fitting, the supervised deep learning (DL) approach for quantification of MR spectroscopy (MRS) data recently showed encouraging results; however, supervised learning requires ground truth fitted spectra, which is not practical. This work investigates the feasibility and efficiency of the LCM-based self-supervised DL method for the analysis of MRS data. Method: We present a novel DL-based method for the quantification of relative metabolite concentrations, using quantum-mechanics simulated metabolite responses and neural networks. We trained, validated, and evaluated the proposed networks with simulated and publicly accessible in-vivo human brain MRS data and compared the performance with traditional methods. A novel adaptive macromolecule fitting algorithm is included. We investigated the performance of the proposed methods in a Monte Carlo (MC) study. Result: The validation using low-SNR simulated data demonstrated that the proposed methods could perform quantification comparably to other methods. The applicability of the proposed method for the quantification of in-vivo MRS data was demonstrated. Our proposed networks have the potential to reduce computation time significantly. Conclusion: The proposed model-constrained deep neural networks trained in a self-supervised manner with complex data can offer fast and efficient quantification of MRS data. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.10.511658v1?rss=1 Authors: Yoo, J. H., Park, Y. W., Kim, D., Park, H., Jeong, B. Abstract: Several lines of evidence indicate verbal abuse (VA) critically impacts the developing brain; however, whether VA results in changes in brain neurochemistry has not been established in humans. Here, we hypothesized that exposure to recurrent parental VA elicits heightened glutamate (Glu) responses during the presentation of swear words, which can be measured with functional magnetic resonance spectroscopy (fMRS). During an emotional Stroop task consisting of blocks of color and swear words, metabolite concentration changes were measured in the ventromedial prefrontal cortex (vmPFC) and the left amygdalohippocampal region (AMHC) of healthy adults (14 F/27 M, 23{+/-}4 years old) using fMRS. The dynamic changes in Glu and their associations with the emotional state of the participants were finally evaluated based on 36 datasets from the vmPFC and 30 from the AMHC. A repeated-measures analysis of covariance revealed a modest effect of parental VA severity on Glu changes in the vmPFC. Furthermore, the total score on the Verbal Abuse Questionnaire by parents (pVAQ) was associated with the Glu response to swear words ({Delta}GluSw e). The interaction term of {Delta}GluSw e and baseline N-acetyl aspartate (NAA) level in the vmPFC could be used to predict state-trait anxiety level and depressive mood. We could not find any significant associations between {Delta}GluSw e in the AMHC and either pVAQ or emotional states. We conclude that parental VA exposure in individuals is associated with a greater Glu response towards VA-related stimuli in the vmPFC and that the accompanying low NAA level may be associated with anxiety level or depressive mood. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
If you're wanting to demystify endoscopy, then tune into this month's episode as we talk with European and RCVS Internal Medicine Specialist, Dr. Mark Dunning. We'll be getting to the bottom of starting out with endoscopy from directing the scope to cleaning and facing those initial fears. Learn the tips for choosing the best retrieval instruments for the job as Mark reveals his most memorable foreign bodies.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.08.31.506120v1?rss=1 Authors: Ma, D. J., Yang, Y., Harguindeguy, N., Tian, Y., Guo, J. Abstract: A novel convolutional neural network based spectral registration (CNN-SR) approach is introduced to achieve efficient and accurate simultaneous frequency-and-phase correction (FPC) of single-voxel MEGA-PRESS magnetic resonance spectroscopy (MRS) data. For this approach, one neural network was trained and validated using a published simulated and in vivo MEGA-PRESS MRS dataset with a wide-range of artificial frequency (0-20 Hz) and phase (0-90{degrees}) offsets applied. The proposed CNN-SR approach was subsequently tested and compared to the sequential FPC deep learning approaches and demonstrated more effective and accurate performance. Furthermore, a large random Gaussian signal-to-noise ratio (SNR 20 and SNR 2.5) and line broadening (0-20 ms) was introduced to the original simulated dataset to investigate our model performance compared to the other deep learning models. The testing showed that CNN-SR was a more accurate quantification tool and resulted in a lower SNR when compared with the other deep learning methods, due to having smaller mean absolute errors in both frequency and phase offset predictions. For Off spectra, the CNN-SR model was capable of correcting frequency offsets with 0.014 {+/-} 0.010 Hz and phase offsets with 0.104 {+/-} 0.076{degrees} absolute errors on average for unseen simulated data with SNR 20 and correcting frequency offsets with 0.678 {+/-} 0.883 Hz and phase offsets with 2.367 {+/-} 2.616{degrees} absolute errors on average at very low SNR (2.5) and line broadening (0-20 ms) introduced. In addition, we tested the simulated dataset with additional SNR and line broadening on a more refined model (CNN-SR+) where the pre-trained CNN-SR was further optimized by minimizing the difference between individual spectra and a common template with unsupervised learning. The performance on Off spectra was improved to 0.058 {+/-} 0.050 Hz for correcting frequency offsets and to 0.416 {+/-} 0.317{degrees} for correcting phase offsets. We further evaluated the ability of our model to process the published Big GABA in vivo dataset and CNN-SR+ achieved the best performance. Moreover, additional frequency and phase offsets (i.e., small, moderate, large) were applied to the in vivo dataset, and CNN-SR+ also demonstrated better performance for FPC when compared to the other deep learning models. These results indicate the utility of using deep learning for spectral registration and demonstrate the application of unsupervised learning in further improving the model to achieve state-of-the-art performance. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer
This month, the IMV imaging clinical team delve into the world of ocular ultrasonography. So if you've ever wondered how to image an eye, where to start, which way to hold the probe or what does the normal eye on ultrasound even look like, then listen in. We talk through the preparation, approach, and common clinical diseases affecting the globe.
Commentary by Dr. Edward Gerstenfeld
If you think about our phones, we all essentially have the same phone yet, it's a deeply personalized experience for each one of us. What if healthcare was like that? - Personalized and holistic, thinking about you, where you are.Vivian S. Lee, M.D., Ph.D., M.B.A., is the President of Verily Health Platforms, overseeing all health care platforms, including Onduo, Healthy at Work, and Verily's Value Suite, among others. She is also the author of The Long Fix: Solving America's Health Care Crisis with Strategies that Work for Everyone. As a healthcare executive, she formerly served as the medical school dean, SVP, and CEO of the University of Utah Health, a $3.5 billion integrated health system and health plan that ranked first among university hospitals in quality and safety. Over her career as an NIH-funded MRI researcher, she has published over 200 articles in leading journals including JAMA and the New England Journal of Medicine and received the Gold Medal of the International Society for Magnetic Resonance in Medicine.If that wasn't enough, Dr. Lee was elected to the National Academy of Medicine in 2015 and was ranked #11 among Becker's 100 most influential people in healthcare in 2019. A Rhodes Scholar, she is a graduate of Harvard College, Oxford University, Harvard Medical School, and NYU Stern School of Business.On this episode of HLTH Matters, Vivian joins hosts Dr. Gautam Gulati and Patricia Bradley to discuss the intersection of health and tech and how it can be very transformative on health care. She describes strategies to solve America's healthcare crisis and how these strategies can not only work for everyone, but also advance healthcare faster than ever before. Listen in for insight on the future of health platforms and the potential they have to advance population health.Topics CoveredVivian's background in medicine and what she does now with VerilyInsight on Vivian's book, The Long Fix: Solving America's Health Care Crisis with Strategies that Work for EveryoneWhat the average individual can do to contribute to the ongoing change of healthcareWhere all the costs of healthcare are coming fromThe Surf and Turf ProblemHow the healthcare system is only designed to treat instead of preventWhat Vivian took away when writing her bookWho Verily is and their purposeVivian's insight on how much more personal healthcare could be and the goal around thatVivian's insight on how unique and personalized healthcare could and should beThe ways Onduo plans on providing more personal results and solutions for peopleThe vision of Verily Health PlatformsHow Vivian defines health as the ability to really live our lives in a productive, comfortable and safe wayVivian's belief that healthcare for every single person in America is the answer to health Connect with Vivian LeeVerily Connect with Dr. Gautam GulatiHLTHDr. Gulati on TwitterDr. Gulati on LinkedIn ResourcesThe Long Fix: Solving America's Health Care Crisis with Strategies that Work for EveryoneOnduoHealthy at WorkVerily's Value Suite Introductory Quote[19:05–19:34]“Even though my book is called The Long Fix, I'm hoping that it's going to be less long now because of the pandemic and the acceleration of these digital health approaches that can be a lot more personalized and holistic, and thinking about you, where you are. So, if you think about our phones, we all essentially have the same phone...but yet it's a very deeply personalized experience for each of us. Now, think about if healthcare were like that.
This month we delve into the world of wireless ultrasound machines, with a review of the GE VScan Air. With Harriet, Amy and Jack discussing how it's held up in practice and out of the road. So if you're considering adding this piece of kit to your practice, tune in and hear about all its fantastic features.
This month we chat all creatures great and small from 15g Poison Dart Frogs to 1 ton Rhinos with European Zoo Specialist, Dr. Simon Girling FRCVS. If you have ever wondered how a lameness investigation on a rhino is performed or the difficulties encountered with scanning the abdomen of a Binturong then tune in! We also hear more on Scottish conversation efforts for Eurasian Beavers and Scottish Wildcats as well as tips for creating a career in zoo medicine and conservation.
Oxford Instruments Chief Executive, Ian Barkshire, and CFO, Gavin Hill present the Full Year 2022 results for the period ended 31 March 2022. Ian Barkshire, Chief Executive Introduction - 00:18 Highlights - 00:45 Horizon Strategy & Progress - 03:20 Group performance - End Markets - 05:30 Gavin Hill, CFO Financial review - 07:08 Ian Barkshire, Chief Executive End market overview - 19:12 Sustainability update - 26:29 Summary and outlook - 28:34 Oxford Instruments plc is a United Kingdom-based provider of high technology products and services to the various industrial companies and scientific research communities. The Company's businesses include Andor, Asylum Research, Imaris, Magnetic Resonance, Nano Analysis, NanoScience, Plasma Technology, WITec and X-Ray Technology. The Company's products include Atomic Force Microscopy; Electron Microscopy, Deposition & Etch Tools, Low Temperature Systems, Optical Imaging, Nuclear Magnetic Resonance, Modular Optical Spectroscopy, Raman Microscopy and X-Ray. The Company's applications include Advanced Manufacturing; Agriculture & Food; Astronomy; Automotive & Aerospace; Bio Imaging & Life Science; Chemical & Catalysis; Energy Generation & Storage; Forensics & Environment; Geology, Petrology & Mining; Metals, Alloys, Composites & Ceramics; Pharma; Photonics; Polymers; Quantum Technologies; and Semiconductors, Microelectronics and Data Storage.
Kelly and Sarah welcome a very special guest to break down all the secrets of the MRI.Hear from DJ Quam, an industry expert, as he breaks down all the things that you always wanted to know. This episode has it all.Academic Drama? Check.Informative Science? Check.Real world recommendation to make MRs better? Check.Sarah oversharing yet again? Check- Check.Join us on the Unchosen Fork.Guest Speaker BioDJ Quam is a Global Product Manager with GE Healthcare's Magnetic Resonance (MR) business. In this role, he oversees end-to-end product development of Magnetic Resonance imaging systems - including engineering research & development, marketing, manufacturing and supply chain strategy and commercial activation of new and existing products. DJ also leads a Milwaukee-area non-profit supporting LGBTQ+ individuals by providing scholarships, grants and access to resources to promote their Health, Equity and Prosperity.DJ holds Bachelor's and Master's Degrees in Biomedical & Electrical Engineering from Marquette University in Milwaukee, Wisconsin. He resides in the area with his husband.ResourcesEngstrom M, McKinnon G, Cozzini C, Wiesinger F. In-phase zero TE musculoskeletal imaging. Magn Reson Med. 2020;83(1):195-202. In-phase zero TE musculoskeletal imagingM. Engstrom, G. McKinnon, C. Cozzini and F. WiesingerMagn Reson Med 2020 Vol. 83 Issue 1 Pages 195-202Accession Number: 31429994 DOI: 10.1002/mrm.27928https://www.ncbi.nlm.nih.gov/pubmed/31429994Follow the Unchosen Fork:FacebookInstagramDisclaimer: The contents of this podcast, including text, graphics, images, and other materials created and/or disseminated by The Unchosen Fork are for informational purposes only. The Contents are NOT intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition, before beginning a nutritional plan and/or taking nutritional supplements. Reliance on any information provided by this podcast, others content appearing on this podcast, or other visitors to the Site is solely at your own risk. None of the contents of this podcast are intended to be relied upon for medical treatment or diagnosis. The Unchosen Fork, their affiliates, nor any of the host family members assumes any liability or responsibility for damage or injury to person or property arising from any use of any product, service, information, or instruction contained on this PodcastSupport the show
Over the thirty-nine episodes of this podcast, Peter Bandettini, PhD (twitter: @fmri_today), has guided interesting conversations with brain scientists of all types about the latest developments, controversies, findings, and challenges in the field of brain mapping. Of course, Dr. Bandettini is an impressive and fascinating scientist in his own right, so we on the Neurosalience production team thought it was time to turn things around and shine the spotlight on Peter. About our "guest": Dr. Bandettini is Chief of the Section on Functional Imaging Methods at the National Institute of Mental Health, as well as Director of the Functional Magnetic Resonance Imaging Core Facility and Director of the Center for Multimodal Neuroimaging. Peter received a bachelor's degree in Physics from Marquette University and his Ph.D. from the Medical College of Wisconsin, followed by postdoctoral training at the Massachusetts General Hospital Nuclear Magnetic Resonance Center and Harvard Medical School, before returning to the Medical College of Wisconsin as assistant professor. In 1999, Dr. Bandettini moved to the National Institute of Mental Health, where he has been ever since. As of this recording, his research has been cited almost 44,000 times, with 5 of his papers having over 2000 citations, 10 papers with over 1000 citations, and 20 with over 500 citations. Dr. Bandettini has also written the book on functional MRI published by MIT Press, entitled, appropriately, “fMRI”. Peter has been highly involved in the Organization for Human Brain Mapping since essentially the beginning, including serving as President, Program Chair, and scientific advisory board member. Peter is also a Fellow of the International Society for Magnetic Resonance in Medicine, where he was awarded the ISMRM Gold Medal in 2020, and he was previously the editor-in-chief of the journal NeuroImage, along with serving as associate editor for that journal and many others. Through all of this, Dr. Bandettini has advised numerous grad students and postdocs, some of whom you'll hear about in today's episode. We'll hear about Peter's approach to mentorship, to science in general, and to science communication, and to much, much more. About our guest host: Kevin Sitek, PhD, is a research scientist at the University of Pittsburgh. Kevin joined the OHBM Communications Committee in 2020 and has worked with the Neurosalience production team since the podcast started in early 2021. You can find Kevin on twitter at @krsitek.
En stor del af vores tid bruges i dag foran en computer eller en telefon, og ifølge forretningsmanden Elon Musk gør det os til en form for cyborgs. Desværre er vi bare nogle pokkers ineffektive cyborgs - for kommunikationen mellem menneske og computer går stadig gennem vores fingre. Det kan der dog rådes bod på. I 2016 startede Elon Musk virksomheden Neuralink, der arbejder på at fremstille en chip, der kan sættes ind i vores hjerner, og gøre os i stand til at kommunikere med den digitale verden. I dag er projektet så langt, at virksomheden blandt andet er lykkedes med at få en abe til at spille Pong på en computer ved hjælp af tankens kraft. Men hvor langt er forskningen egentlig med at kunne afkode hjernens signaler og læse vores tanker? Og bør man, som Asbjørn i denne episode, være bekymret for konsekvenserne af at få en hjernechip? Det undersøger Brainstorm i denne episode. NB: Brainstorm har kontaktet Neuralink i et forsøg på at få svar på forskernes kommentarer, men har ikke hørt noget endnu. Kommer det, vil vi opdatere jer i en kommende episode. Brainstorm er støttet af Lundbeckfonden. Medvirkende: Hartwig Siebner, leder af DRCMR (Danish Research Center for Magnetic Resonance og klinisk professor i præcisionsmedicin ved Hvidovre Hospital. Thomas Ploug, professor på Det Humanistiske og Samfundsvidenskabelige Fakultet og Centre for Applied Ethics and Philosophy of Science på Aalborg Universitet. Link til Neuralinks præsentationsvideo med aben Pager.
Your Natural Dog with Angela Ardolino - Formerly It's A Dog's Life
Dr. Susan Wagner was well on her way to becoming a neurologist when she found out she had fibromyalgia and chronic fatigue. This led her to discover energy work and integrative medicine, which she now incorporates into her neurology work. In this episode, Dr. Wagner shares her perspective on the state of integrative medicine today. She also explains how our energy affects our pets and offers advice to help you create a safe space for your animals to thrive. Episode Recap:How did you get interested in integrative medicine? (0:54)It's taken a while for people to accept the benefits of integrative medicine, but things are shifting (8:41)Full spectrum hemp extract is legal, but many are still hesitant because of challenges with the FDA (11:07)Examples of how energy work and CBD have benefited animals (18:54)How do I help a new rescue get along with my other dogs? (32:16)Tesla's theory of Magnetic Resonance (37:02)How to learn more from Dr. Wagner (44:40)Resources:Have a question for Angela? Call (252) 377-4555 to submit itEnter the code RADIO at CBDdoghealth.com for 15% off your first orderLisa Spector's Zen Pet Music“Through a Dog's Ear”Angela's WebsiteCBD Dog HealthSign up for a full holistic consultationFollow Angela on Facebook and Instagram
Our bodies are scanned, probed, imaged, sampled, and transformed into data by clinicians and technologists. In Giving Bodies Back to Data: Image Makers, Bricolage, and Reinvention in Magnetic Resonance Technology (MIT Press, 2021), Silvia Casini reveals the affective relations and materiality that turn data into image–and in so doing, gives bodies back to data. Opening the black box of MRI technology, Casini examines the bodily, situated aspects of visualization practices around the development of this technology. Reframing existing narratives of biomedical innovation, she emphasizes the important but often overlooked roles played by aesthetics, affectivity, and craft practice in medical visualization. Combining history, theory, laboratory ethnography, archival research, and collaborative art-science, Casini retrieves the multiple presences and agencies of bodies in data visualization, mapping the traces of scientists' body work and embodied imagination. She presents an in-depth ethnographic study of MRI development at the University of Aberdeen's biomedical physics laboratory, from the construction of the first whole-body scanner for clinical purposes through the evolution of the FFC-MRI. Going beyond her original focus on MRI, she analyzes a selection of neuroscience- or biomedicine-inspired interventions by artists in media ranging from sculpture to virtual reality. Finally, she presents a methodology for designing and carrying out small-scale art-science projects, describing a collaboration that she herself arranged, highlighting the relational and aesthetic-laden character of data that are the product of craftsmanship and affective labor at the laboratory bench. Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience