POPULARITY
JueとMoiのふたり雑談。時間栄養学の書籍を読んでの感想回です。同じ内容の食事でも、時間によって体への影響が変わる?時間栄養学(Chrono-nutrition)は、「いつ食べるか」に注目した栄養学の分野。従来の栄養学が「何を・どれだけ食べるか」を重視していたのに対し、時間栄養学は食事のタイミングと体内時計の関係に着目した研究です。時間栄養学とは?/セブンで売ってるサイクルミー/何を食べるかではなく、いつ食べるか?/体内時計とメラトニンの関係/良質な睡眠のための習慣/松果体を活性化する音楽/時間が不規則なシフトワーカーさんはどうすれば?/夜遅くに食事をせざるを得ない場合の対処法/目的によって食べるものが変わる/体内時計を動かすには魚の脂がおすすめ/朝・昼・夜の食事のバランス/運動するのに最適な時間帯<Reference>今回、JueとMoiが読んだ本古谷彰子 著, 柴田重信 監修『食べる時間を変えれば健康になる 時間栄養学入門』ディスカヴァー携書182ディスカヴァー・トゥエンティワン2017年「松果体とメラトニンの関係」参考サイト「秋の夜長の光をコントロールして熟睡」首都圏デジタル産業健康保険組合<話す人>Jue:ゆったりまったり話すのが好きな在日コリアンのWebディレクター。趣味は旅・グルメ・料理。Instagram @jue_318Moi:インタビュアー / ライター / 制作ディレクター。元学芸員。アートとヨガが好き。カジュアルに生理を語るメディア「Moi!Period」運営。http://moi-period.com/他の配信Podcast「Cc: Cast」「MUSEUM Chat!」Instagram @moi_hanawaInstagram @karada_iceX @KARADA_ICE
is.gd/alcarria | akiaura, LONOWN & Baby Jane, SIIE, Camlann, Bruce Grooves, Pleasure Voyage, Isolationsgemeinschaft, Staatseinde, NNHMN, Mufti, LukHash, HNNY, Flevans 🔊 Podcast: https://is.gd/alcarria 📻 Radio: RUAH 🌐 Alcalá de Henares (Madrid) 🖱️ www.ruah.es 🗓️ MIE 17:00h Radio Malva 104.9 FM 🌐 Valencia 🖱️ radiomalva.org 🗓️ DOM 18:30h Radio Kolor Cuenca 106.2 FM 🌐 Cuenca 🖱️ www.radiokolor.es 🗓️ JUE 15:00h Cuac FM 103.4 FM 🌐 Á Coruña 🖱️ cuacfm.org 🗓️ VIE 17:00h Onda Cabanillas 107.0 FM 🌐 Cabanillas (GU) 🖱️ aytocabanillas.org 🗓️ MIE 21:00h
is.gd/alcarria | Pearz (Bordello A Parigi), Waveshaper (TimeSlave "Masters of Outrun"), Naukograd, Jesper Ryom (Delicieuse Records), Devante Embers ("Ten Years Of Monologues Records Vol. 1: Deep Gold"), Salvar Doñana, RFX, Paradise Cop (Axel Casas), Peter Palace, Konstantin Gropper & Ziggy Has Ardeur, Massimo Cambiano 🔊 Podcast: https://is.gd/alcarria 📻 Radio: RUAH 🌐 Alcalá de Henares (Madrid) 🖱️ www.ruah.es 🗓️ MIE 17:00h Radio Malva 104.9 FM 🌐 Valencia 🖱️ radiomalva.org 🗓️ DOM 18:30h Radio Kolor Cuenca 106.2 FM 🌐 Cuenca 🖱️ www.radiokolor.es 🗓️ JUE 15:00h Cuac FM 103.4 FM 🌐 Á Coruña 🖱️ cuacfm.org 🗓️ VIE 17:00h Onda Cabanillas 107.0 FM 🌐 Cabanillas (GU) 🖱️ aytocabanillas.org 🗓️ MIE 21:00h
is.gd/alcarria | Juan Soto, Miel De Montagne, Tenebran, Azaria, Parissior, SHUFFA, Kapote, Laurence Guy & J. Peacock, Laura Krieg, Denuit, Linea Maginot, French Police, ORAX 🔊 Podcast: https://is.gd/alcarria 📻 Radio: RUAH 🌐 Alcalá de Henares (Madrid) 🖱️ www.ruah.es 🗓️ MIE 17:00h Radio Malva 104.9 FM 🌐 Valencia 🖱️ radiomalva.org 🗓️ DOM 18:30h Radio Kolor Cuenca 106.2 FM 🌐 Cuenca 🖱️ www.radiokolor.es 🗓️ JUE 15:00h Cuac FM 103.4 FM 🌐 Á Coruña 🖱️ cuacfm.org 🗓️ VIE 17:00h Onda Cabanillas 107.0 FM 🌐 Cabanillas (GU) 🖱️ aytocabanillas.org 🗓️ MIE 21:00h
JUE & Hookuo 03.31.25 | VISLA FM by VISLA
There's living coral, and then there's Coral—the iconicity and imaginary of living coral. As Melody Jue writes in Coralations, coral alternates between signifying an organism and signifying an environment, all too often imagined as a tourist destination. In rethinking the limitations of Coral, Jue opens up possibilities for a more expansive sense of environmental media, more inclusive goals for multispecies justice, and more nuanced forms of oceanic care work. Here, Jue is joined in conversation with Ann Elias. Melody Jue is associate professor of English at the University of California, Santa Barbara. Jue is author of Coralations and Wild Blue Media: Thinking through Seawater and coeditor of Saturation: An Elemental Politics with Rafico Ruiz.Ann Elias is professor emerita of visual culture at the University of Sydney. Elias is author of many books including Coral Empire: Underwater Oceans, Colonial Tropics, Visual Modernity.REFERENCES:Coral Whisperers (Irus Braverman)Situated Knowledges (Donna Haraway, in the journal Feminist Studies)Her Seal Skin Coat (Lauren Beukes, short story)Sylvia EarleJacques CousteauCalifornia Against the Sea (Rosanna Xia)Jean PainlevéZoological Surrealism (James Leo Cahill)Alien Ocean (Stefan Helmreich)Chasing Coral documentaryCoralations by Melody Jue is available from University of Minnesota Press. This book is part of the Forerunners series, and an open-access edition is available to read free online at manifold.umn.edu.
is.gd/alcarria | Fragrance., Das Beat, Principleasure, GMGN, DJ DLG, ACIDULÉ, Defensa Eslava, RINA PAVAR, CRUEL REFLECTIONS, Slow Danse With The Dead, Hotmood 🔊 Podcast: https://is.gd/alcarria 📻 Radio: RUAH 🌐 Alcalá de Henares (Madrid) 🖱️ www.ruah.es 🗓️ MIE 17:00h Radio Malva 104.9 FM 🌐 Valencia 🖱️ radiomalva.org 🗓️ DOM 18:30h Radio Kolor Cuenca 106.2 FM 🌐 Cuenca 🖱️ www.radiokolor.es 🗓️ JUE 15:00h Cuac FM 103.4 FM 🌐 Á Coruña 🖱️ cuacfm.org 🗓️ VIE 17:00h Onda Cabanillas 107.0 FM 🌐 Cabanillas (GU) 🖱️ aytocabanillas.org 🗓️ MIE 21:00h
is.gd/alcarria | Keen K (Waste Editions "VV.AA_192"), SUPERNOVA 1006, Miami Horror, Fertita, Madd Rod, TOKYO ROSE & ALEX, Pagan, Dark Vektor, Tres Dement, Marie Davidson 🔊 Podcast: https://is.gd/alcarria 📻 Radio: RUAH 🌐 Alcalá de Henares (Madrid) 🖱️ www.ruah.es 🗓️ MIE 17:00h Radio Malva 104.9 FM 🌐 Valencia 🖱️ radiomalva.org 🗓️ DOM 18:30h Radio Kolor Cuenca 106.2 FM 🌐 Cuenca 🖱️ www.radiokolor.es 🗓️ JUE 15:00h Cuac FM 103.4 FM 🌐 Á Coruña 🖱️ cuacfm.org 🗓️ VIE 17:00h Onda Cabanillas 107.0 FM 🌐 Cabanillas (GU) 🖱️ aytocabanillas.org 🗓️ MIE 21:00h
is.gd/alcarria | GARAVENTA, Morgan Willis, Close Counters, Neo Tokyo Philharmonic, Children of The Night, JMIC, Mechudo, Cara Carpaccio, Luca dell'Orso, Haunt Me, HALLOWS, Stogov 🔊 Podcast: https://is.gd/alcarria 📻 Radio: RUAH 🌐 Alcalá de Henares (Madrid) 🖱️ www.ruah.es 🗓️ MIE 17:00h Radio Malva 104.9 FM 🌐 Valencia 🖱️ radiomalva.org 🗓️ DOM 18:30h Radio Kolor Cuenca 106.2 FM 🌐 Cuenca 🖱️ www.radiokolor.es 🗓️ JUE 15:00h Cuac FM 103.4 FM 🌐 Á Coruña 🖱️ cuacfm.org 🗓️ VIE 17:00h Onda Cabanillas 107.0 FM 🌐 Cabanillas (GU) 🖱️ aytocabanillas.org 🗓️ MIE 21:00h
is.gd/alcarria | SHEE, BowAsWell, QNAUT, JESSY MACH, HARLEM electronics, HUIR, VIQ, Corps Diplomatique, Bragolin, undersaken, Dirty River, Flevans 🔊 Podcast: https://is.gd/alcarria 📻 Radio: RUAH 🌐 Alcalá de Henares (Madrid) 🖱️ www.ruah.es 🗓️ MIE 17:00h Radio Malva 104.9 FM 🌐 Valencia 🖱️ radiomalva.org 🗓️ DOM 18:30h Radio Kolor Cuenca 106.2 FM 🌐 Cuenca 🖱️ www.radiokolor.es 🗓️ JUE 15:00h Cuac FM 103.4 FM 🌐 Á Coruña 🖱️ cuacfm.org 🗓️ VIE 17:00h Onda Cabanillas 107.0 FM 🌐 Cabanillas (GU) 🖱️ aytocabanillas.org 🗓️ MIE 21:00h
is.gd/alcarria | STM & vinter, Uppermost, KOMPROMAT, KNEECAP, Holy Fuck, Miel De Montagne, аудиопреступление, Tech Support, Gaspar Muniz & Marcos Tocae (Gop Tun "Gop Edits Vol. 4"), LTD, Occams Laser, Black Spuma 🔊 Podcast: https://is.gd/alcarria 📻 Radio: RUAH 🌐 Alcalá de Henares (Madrid) 🖱️ www.ruah.es 🗓️ MIE 17:00h Radio Malva 104.9 FM 🌐 Valencia 🖱️ radiomalva.org 🗓️ DOM 18:30h Radio Kolor Cuenca 106.2 FM 🌐 Cuenca 🖱️ www.radiokolor.es 🗓️ JUE 15:00h Cuac FM 103.4 FM 🌐 Á Coruña 🖱️ cuacfm.org 🗓️ VIE 17:00h Onda Cabanillas 107.0 FM 🌐 Cabanillas (GU) 🖱️ aytocabanillas.org 🗓️ MIE 21:00h
is.gd/alcarria | Molchat Doma, Qrion, Sunset Wave, akiaura x LONOWN, BICEP & ELIZA, Disco Feelings, Jessy Mach, Tommaso Conforti, Teak, MAGNAVOLT, MASKED, Macroblank 🔊 Podcast: https://is.gd/alcarria 📻 Radio: RUAH 🌐 Alcalá de Henares (Madrid) 🖱️ www.ruah.es 🗓️ MIE 17:00h Radio Malva 104.9 FM 🌐 Valencia 🖱️ radiomalva.org 🗓️ DOM 18:30h Radio Kolor Cuenca 106.2 FM 🌐 Cuenca 🖱️ www.radiokolor.es 🗓️ JUE 15:00h Cuac FM 103.4 FM 🌐 Á Coruña 🖱️ cuacfm.org 🗓️ VIE 17:00h Onda Cabanillas 107.0 FM 🌐 Cabanillas (GU) 🖱️ aytocabanillas.org 🗓️ MIE 21:00h
is.gd/alcarria | Emil Rottmayer, Brother Julian, Skibblez, Artek Electronica & New Sovietwave, Sunset Wave, DAN TERMINUS, Matisa, DJ DLG, Oscar Wallyn, Amarcord, Relative, PechFunk 🔊 Podcast: https://is.gd/alcarria 📻 Radio: RUAH 🌐 Alcalá de Henares (Madrid) 🖱️ www.ruah.es 🗓️ MIE 17:00h Radio Malva 104.9 FM 🌐 Valencia 🖱️ radiomalva.org 🗓️ DOM 18:30h Radio Kolor Cuenca 106.2 FM 🌐 Cuenca 🖱️ www.radiokolor.es 🗓️ JUE 15:00h Cuac FM 103.4 FM 🌐 Á Coruña 🖱️ cuacfm.org 🗓️ VIE 17:00h Onda Cabanillas 107.0 FM 🌐 Cabanillas (GU) 🖱️ aytocabanillas.org 🗓️ MIE 21:00h
is.gd/alcarria | SHEE, Mike Haunted, Hyperstellar, Qrion, Vincenzo (Razor-N-Tape "Family Affair Vol 4."), Danger, Session Victim (Permanent Vacation "Selected Label Works 11"), Telemetric, Hiatt DB (Nocturnal Hazard "V.A. Edit Sampler 03"), Gigi Croccante, Auto Sacramental 🔊 Podcast: https://is.gd/alcarria 📻 Radio: RUAH 🌐 Alcalá de Henares (Madrid) 🖱️ www.ruah.es 🗓️ MIE 17:00h Radio Malva 104.9 FM 🌐 Valencia 🖱️ radiomalva.org 🗓️ DOM 18:30h Radio Kolor Cuenca 106.2 FM 🌐 Cuenca 🖱️ www.radiokolor.es 🗓️ JUE 15:00h Cuac FM 103.4 FM 🌐 Á Coruña 🖱️ cuacfm.org 🗓️ VIE 17:00h Onda Cabanillas 107.0 FM 🌐 Cabanillas (GU) 🖱️ aytocabanillas.org 🗓️ MIE 21:00h
is.gd/alcarria | R. Missing, Jorkes, Funkyjaws & Los Protos, E.V.A, AWITW, Jony Arcada, Noda & Wolfers, ideesnoires (L.O.V.E. Ltd "Dawn"), The Last Concorde, Miel De Montagne, Guts ("Straight From The Decks Vol . 4"), Alex Banks 🔊 Podcast: https://is.gd/alcarria 📻 Radio: RUAH 🌐 Alcalá de Henares (Madrid) 🖱️ www.ruah.es 🗓️ MIE 17:00h Radio Malva 104.9 FM 🌐 Valencia 🖱️ radiomalva.org 🗓️ DOM 18:30h Radio Kolor Cuenca 106.2 FM 🌐 Cuenca 🖱️ www.radiokolor.es 🗓️ JUE 15:00h Cuac FM 103.4 FM 🌐 Á Coruña 🖱️ cuacfm.org 🗓️ VIE 17:00h Onda Cabanillas 107.0 FM 🌐 Cabanillas (GU) 🖱️ aytocabanillas.org 🗓️ MIE 21:00h
Uno de los guerreros valientes del pueblo de Israel fue el juez llamado Jefté, de la región de Galaad. Cuenta la historia sagrada que tan pronto como derrotó a sus enemigos los amonitas, conquistando veinte de sus ciudades, Jefté tuvo que lidiar con sus presuntos hermanos de la tribu de Efraín. Éstos, con manifiesta desfachatez y hostilidad, le reclamaron a Jefté: —¿Por qué fuiste a luchar contra los amonitas sin llamarnos para ir contigo? ¡Ahora prenderemos fuego a tu casa, contigo dentro! Jefté respondió: —Mi pueblo y yo estábamos librando una gran contienda con los amonitas y, aunque yo los llamé, ustedes no me libraron de su poder. Cuando vi que ustedes no me ayudarían, arriesgué mi vida, marché contra los amonitas, y el Señor los entregó en mis manos. ¿Por qué, pues, han subido hoy a luchar contra mí?1 Acto seguido, a Jefté le tocó pelear contra los de la tribu de Efraín y vencerlos a ellos también. Después de la derrota, cuando los sobrevivientes de Efraín procuraban cruzar inadvertidos el Jordán, los hombres de Galaad los detenían en los vados del río y los identificaban con sólo decirles que pronunciaran la palabra hebrea shibolet, que significa «corriente de agua». En aquellos tiempos el idioma hebreo presentaba ciertas diferencias dialectales en las diversas regiones de Palestina, y los de Galaad sabían que los de Efraín no pronunciaban las eses como ellos. De ahí que, en lugar de decir shibolet con la hache, pronunciando las consonantes «sh» algo más suave que una che, dijeran «sibolet» sin la hache intermedia, y de ese modo se descubrían. No podían ocultar su verdadera identidad. ¡Esa insignificante diferencia de pronunciación les costó la vida nada menos que a cuarenta y dos mil hombres! Así como una sola palabra llegó a identificar y a delatar a aquellos hombres en los tiempos bíblicos de los jueces de Israel, y hasta determinó su destino, también una sola palabra nos identifica y nos delata a nosotros en la actualidad, sólo que en vez de determinar nuestro destino, muestra más bien nuestros orígenes. Se trata de la palabra «gracias», que pronunciándola así, con la ce como si fuera una ese sencilla, nos identifica como hispanoamericanos, mientras que si pronunciáramos la ce más cerca de la zeta de modo que sonara «grathias», nos identificaría como españoles de la península ibérica. Pero no es esa diferencia de pronunciación lo que revela nuestros orígenes, sino el modo en que la empleamos. Pues lo que nos caracteriza como personas que sabemos agradecer los favores recibidos es el haber aprendido a dar las gracias de un modo natural y no afectado, espontáneo y no forzado, sincero y no fingido, y regular y no esporádico, como quien lo hace de costumbre y por cultura. ¡Por algo será que a los niños de todas las edades y culturas se les ha enseñado lo importante que es emplear la palabra «gracias» con liberalidad, como evidencia de buenos modales, buenas costumbres y buena educación! Carlos ReyUn Mensaje a la Concienciawww.conciencia.net 1 Jue 12:1-3
is.gd/alcarria | Carlita, Baby Berserk, Das Beat, Tom Noble, Ca99 (theBasement Discos "MADE IN FRANCE"), SIIE, TASSEL, Ultraboss, Phaserland, PHAZER AXE (Werkstatt Recordings "Future Wastelands"), Lup Ino, Maribou State & Holly Walker 🔊 Podcast: https://is.gd/alcarria 📻 Radio: RUAH 🌐 Alcalá de Henares (Madrid) 🖱️ www.ruah.es 🗓️ MIE 17:00h Radio Malva 104.9 FM 🌐 Valencia 🖱️ radiomalva.org 🗓️ DOM 18:30h Radio Kolor Cuenca 106.2 FM 🌐 Cuenca 🖱️ www.radiokolor.es 🗓️ JUE 15:00h Cuac FM 103.4 FM 🌐 Á Coruña 🖱️ cuacfm.org 🗓️ VIE 17:00h Onda Cabanillas 107.0 FM 🌐 Cabanillas (GU) 🖱️ aytocabanillas.org 🗓️ MIE 21:00h
This month hosts Teri and Ed recap The Mighty Thor (1966) 408 published Jue 1989 and Jane Foster Valkyrie (2019) 02 published August 2019.
This month hosts Teri and Ed recap The Mighty Thor (1966) 408 published Jue 1989 and Jane Foster Valkyrie (2019) 02 published August 2019.
is.gd/alcarria | Pilo, DiscoGram, iacon, JG OUTSIDER, AFFKT, New Hook (Live At Robert Johnson "Lifesaver 5 Compilation - Tell Me Something Good"), VOX LOW, DEAD., Панелька, Wild Classical Music Ensemble, Tensnake, Turbo Knight 🔊 Podcast: https://is.gd/alcarria 📻 Radio: RUAH 🌐 Alcalá de Henares (Madrid) 🖱️ www.ruah.es 🗓️ MIE 17:00h Radio Malva 104.9 FM 🌐 Valencia 🖱️ radiomalva.org 🗓️ DOM 18:30h Radio Kolor Cuenca 106.2 FM 🌐 Cuenca 🖱️ www.radiokolor.es 🗓️ JUE 15:00h Cuac FM 103.4 FM 🌐 Á Coruña 🖱️ cuacfm.org 🗓️ VIE 17:00h Onda Cabanillas 107.0 FM 🌐 Cabanillas (GU) 🖱️ aytocabanillas.org 🗓️ MIE 21:00h
is.gd/alcarria | Joi N'Juno, Corbeau Hangs, Karl Kave & Durian, Carpenter Brut, A-Reis, Random Factor, Меланхолия Тудэй, Rue Oberkampf, Bending Grid & Power Rob, Levantine, Señor Chugger, Legowelt 🔊 Podcast: https://is.gd/alcarria 📻 Radio: RUAH 🌐 Alcalá de Henares (Madrid) 🖱️ www.ruah.es 🗓️ MIE 17:00h Radio Malva 104.9 FM 🌐 Valencia 🖱️ radiomalva.org 🗓️ DOM 18:30h Radio Kolor Cuenca 106.2 FM 🌐 Cuenca 🖱️ www.radiokolor.es 🗓️ JUE 15:00h Cuac FM 103.4 FM 🌐 Á Coruña 🖱️ cuacfm.org 🗓️ VIE 17:00h Onda Cabanillas 107.0 FM 🌐 Cabanillas (GU) 🖱️ aytocabanillas.org 🗓️ MIE 21:00h
is.gd/alcarria | Shabi, Louis La Roche, Turbo Knight, DRYVE, Macroblank, upusen, Asif (Les Disques Bongo Joe "Maghreb K7 Club - Disco Singles Volume 3"), Rick Stereo, Kāve, Figure x Destryur 🔊 Podcast: https://is.gd/alcarria 📻 Radio: RUAH 🌐 Alcalá de Henares (Madrid) 🖱️ www.ruah.es 🗓️ MIE 17:00h Radio Malva 104.9 FM 🌐 Valencia 🖱️ radiomalva.org 🗓️ DOM 18:30h Radio Kolor Cuenca 106.2 FM 🌐 Cuenca 🖱️ www.radiokolor.es 🗓️ JUE 15:00h Cuac FM 103.4 FM 🌐 Á Coruña 🖱️ cuacfm.org 🗓️ VIE 17:00h Onda Cabanillas 107.0 FM 🌐 Cabanillas (GU) 🖱️ aytocabanillas.org 🗓️ MIE 21:00h
is.gd/alcarria | Segunda parte del repaso de lanzamientos del verano | Midnight Danger, Street Player, David Bay, DEADLIFE, Alastair Lane, Gigi Croccante, Mondmann, salute, bicycle ride, Molchat Doma, Ploho, Rayko 🔊 Podcast: https://is.gd/alcarria 📻 Radio: RUAH 🌐 Alcalá de Henares (Madrid) 🖱️ www.ruah.es 🗓️ MIE 17:00h Radio Malva 104.9 FM 🌐 Valencia 🖱️ radiomalva.org 🗓️ DOM 18:30h Radio Kolor Cuenca 106.2 FM 🌐 Cuenca 🖱️ www.radiokolor.es 🗓️ JUE 15:00h Cuac FM 103.4 FM 🌐 Á Coruña 🖱️ cuacfm.org 🗓️ VIE 17:00h Onda Cabanillas 107.0 FM 🌐 Cabanillas (GU) 🖱️ aytocabanillas.org 🗓️ MIE 21:00h
JueとMoi, 久しぶりのふたりトーク。 体のこと、ライフスタイルのこと、仕事のことを話します。 久しぶり〜/最近どう?/Jueの引越し/子どものこと/仕事、どう?/ヨガに興味ある/体がかたいとヨガは無理?/ヨガで目指すこと/20代と30代の違い/今後のKARADA ICE <話す人> Jue:ゆったりまったり話すのが好きな在日コリアンのWebディレクター。趣味は旅・グルメ・料理。 Instagram @jo_ktnr Moi:インタビュアー、ライター。元学芸員。アートとヨガが好き。カジュアルに生理を語るメディア「Moi!Period」運営。 http://moi-period.com/ クリエイティブとビジネスについてトークする「Cc: Cast」というPodcastにも参加しています。 Instagram @moi_hanawa Instagram @karada_ice X @KARADA_ICE
is.gd/alcarria | INICIO TEMPORADA 15, 2024/2025 | Supertaste, Late Guest At The Party, SHEE, Alles, Dame Area, Occams Laser, Adieu Aru, Laurence Guy, CRi, Final Djs, Луч, Luttrell 🔊 Podcast: https://is.gd/alcarria 📻 Radio: RUAH 🌐 Alcalá de Henares (Madrid) 🖱️ www.ruah.es 🗓️ MIE 17:00h Radio Malva 104.9 FM 🌐 Valencia 🖱️ radiomalva.org 🗓️ DOM 18:30h Radio Kolor Cuenca 106.2 FM 🌐 Cuenca 🖱️ www.radiokolor.es 🗓️ JUE 15:00h Cuac FM 103.4 FM 🌐 Á Coruña 🖱️ cuacfm.org 🗓️ VIE 17:00h Onda Cabanillas 107.0 FM 🌐 Cabanillas (GU) 🖱️ aytocabanillas.org 🗓️ MIE 21:00h
(Día Internacional de las Niñas) «Llegaron las primeras noticias.... Regresó uno de los peones... hablando de... que [habían desenterrado] a la Chepita.... »La habían rajao [—anunció—]. Jue matada.... »A la mujer del barbero la sacaron de la cama.... En cuanto le hablaron de ir a reconocer el cadáver, se puso verde y echó a temblar.... Lloró y pidió perdón a grandes voces, a pesar de que juró y rejuró ser inocente. Ella no había hecho nada malo, no había cometido ningún crimen.... Por primera vez la fatalidad la hacía verse en tales cosas. Y Chepita, a quien quería como a hija suya, le había pedido con lágrimas en los ojos que le hiciera [el] favor [de practicarle el aborto], porque, según decía la pobre, de lo contrario su papá la iba a matar a palos. Sólo por eso decidió ayudarla.... El caso era avanzado, la operación resultó más seria de lo que suponía [y] la muchacha perdió el conocimiento.... Fue así como, sin saber ni a qué horas, echó mano al cuchillo de la cocina para ayudarse. Y la desgracia hizo que no se fijara en un detalle: el tal cuchillo resultó con demasiado filo.... »Ñor Sánchez... anonadado por la pena... no [pudo] contener más la imperiosa necesidad de desahogar... su inmensa aflicción... En voz baja y dolorida, el pobre viejo [dio] rienda suelta a su dolor.... Ya en la maraña blanca de su barba [temblaban] gruesos lagrimones cuando [dijo]: —¡Yo tengo la culpa’e todo...! ¿Pa qué me puse a atormentar a la pobre? La cosa ya estaba hecha, y aunque juera como juera, la verdá es que su hijo también era hijo’e Dios, y tal vez hasta iba a ser un güen muchacho. ¿Por qué me puse a hablar tonteras? Tal vez jue por estar tan viejo y tan pobre, y sentir uno que no puede vengarse como un hombre de verdá... ¡Pobre m’hija, cómo se me jue a morir tan de mala manera! Ora me he quedao solo, a estos años.... ¿Cómo voy a hacer yo? ¿Pa qué quiero vivir así? No sé por qué el Cielo me aflige de este modo. No sé qué gran pecao me está cobrando Dios...»1 No cabe la menor duda. Una de las tragedias más grandes es la muerte espantosa no sólo de una indefensa criatura sino, al mismo tiempo, de la madre que pudo haberla dado a luz. Así lo siente, en lo más profundo de su ser, el viejo Sánchez en este capítulo de la novela Gentes y gentecillas del escritor costarricense Carlos Luis Fallas. A Chepita la había seducido y dejado embarazada el hijo del contratista del aserradero, y ñor Sánchez, que había amenazado a su hija poco antes de que ella muriera por el aborto provocado, hubiera preferido mil veces haber muerto él mismo al sentirse culpable de la muerte de la desesperada joven. Quiera Dios que en cada familia determinemos dejar de caer en el error y en la contradicción en que cayó el viejo Sánchez. ¡Ya basta de hacer las veces de Dios nuestro Creador y decidir nosotros más bien cuáles niños merecen nacer y cuáles morir, y justificar el porqué! ¡Y basta de echarle la culpa a Dios de lo que sabemos que somos culpables nosotros! La verdad es que Dios no sólo reconoce a esos seres inocentes indefensos, sino que quiere reconocernos a todos como hijos suyos, y para eso basta con que le pidamos que nos perdone y nos libre de toda culpa, y que reconozcamos como nuestro Salvador a su Hijo Jesucristo.2 Carlos ReyUn Mensaje a la Concienciawww.conciencia.net 1 Carlos Luis Fallas, Gentes y gentecillas (San José: Editorial Costa Rica, 1994), pp. 124-28. 2 Jn 1:12; 1Jn 1:9
is.gd/alcarria | FINAL 14ª TEMPORADA 2023-2024 | Elijo algunos temas de la 14ª temporada | Red Axes, Naux, Street Player, Laurence Guy, GWENDOLINE, LOVATARAXX, CATHEDRALIS, SAVAGE GROUNDS, Never Dull, DJ Krug, Луч, The Last Concorde, Kāve, prod.Kitty 🔊 Podcast: https://is.gd/alcarria 📻 Radio: RUAH 🌐 Alcalá de Henares (Madrid) 🖱️ www.ruah.es 🗓️ MIE 17:00h Radio Malva 104.9 FM 🌐 Valencia 🖱️ radiomalva.org 🗓️ DOM 18:30h Radio Kolor Cuenca 106.2 FM 🌐 Cuenca 🖱️ www.radiokolor.es 🗓️ JUE 15:00h Cuac FM 103.4 FM 🌐 Á Coruña 🖱️ cuacfm.org 🗓️ VIE 17:00h Onda Cabanillas 107.0 FM 🌐 Cabanillas (GU) 🖱️ aytocabanillas.org 🗓️ MIE 21:00h
is.gd/alcarria | Laurence Guy, Macroblank, Ortrotasce, 3FORCE, Dj Steef, NOIZINSKI, Drop Out Orchestra, Cocktail Cool, Mom's Spaghetti, Capofortuna, Shades of Thunder, Sub Morphine 🔊 Podcast: https://is.gd/alcarria 📻 Radio: RUAH 🌐 Alcalá de Henares (Madrid) 🖱️ www.ruah.es 🗓️ MIE 17:00h Radio Malva 104.9 FM 🌐 Valencia 🖱️ radiomalva.org 🗓️ DOM 18:30h Radio Kolor Cuenca 106.2 FM 🌐 Cuenca 🖱️ www.radiokolor.es 🗓️ JUE 15:00h Cuac FM 103.4 FM 🌐 Á Coruña 🖱️ cuacfm.org 🗓️ VIE 17:00h Onda Cabanillas 107.0 FM 🌐 Cabanillas (GU) 🖱️ aytocabanillas.org 🗓️ MIE 21:00h
これまでもしばしば話題にしてきた生理の話。 生理をめぐる体のはたらきとして、1ヶ月の中で2つのホルモン(エストロゲンとプロゲステロン)が体や心の状態に影響します。 今回は改めて、生理のしくみ、生理の時の体や心の状態についてトークします。 生理の周期/しくみ/エストロゲンとプロゲステロン/生理前後のメンタル/PMS(月経前症候群)/骨盤底筋を鍛える/月経コントロール/感情的になりやすかったり、イライラしたり/自分の感じていることを受け入れる/自分の状態をきちんと知る <参考リンクなど> 生理・からだのことを知る、おすすめ書籍 高尾美穂『大丈夫だよ 女性ホルモンと人生のお話し111』講談社、2022年 細川モモ『生理で知っておくべきこと』日経BP、2021年 森田敦子『潤うからだ』ワニブックス、2017年 Clue 生理管理・排卵予測アプリ 科学的なデータを用いた生理・排卵・PMSの予測など心と体の状態を知ることをサポートする生理管理アプリ。 https://apps.apple.com/jp/app/clue-%E7%94%9F%E7%90%86%E7%AE%A1%E7%90%86%E3%82%A2%E3%83%97%E3%83%AA/id657189652 カジュアルに生理を語るメディア Moi! Period 生理にまつわる個人の体験談やエッセイ。 https://moi-period.com/ <話す人> Jue: ゆったりまったり話すのが好きな在日コリアンのWebディレクター。趣味は旅・グルメ・料理。 Instagram @jo_ktnr Moi: インタビュアー、ライター。元学芸員。アートとヨガが好き。カジュアルに生理を語るメディア「Moi!Period」運営。 http://moi-period.com/ クリエイティブとビジネスについてトークする「Cc: Cast」というPodcastにも参加しています。 Instagram @moi_hanawa Instagram @karada_ice X @KARADA_ICE
is.gd/alcarria | Never Dull, CATHEDRALIS, Gigi Croccante, Close Counters, Rogue VHS & Neologisticism, Leslie Young, Street Choice, iacon, AVELINE, SOVIET GYM, Llewellyn 🔊 Podcast: https://is.gd/alcarria 📻 Radio: RUAH 🌐 Alcalá de Henares (Madrid) 🖱️ www.ruah.es 🗓️ MIE 17:00h Radio Malva 104.9 FM 🌐 Valencia 🖱️ radiomalva.org 🗓️ DOM 18:30h Radio Kolor Cuenca 106.2 FM 🌐 Cuenca 🖱️ www.radiokolor.es 🗓️ JUE 15:00h Cuac FM 103.4 FM 🌐 Á Coruña 🖱️ cuacfm.org 🗓️ VIE 17:00h Radio Arrebato 107.4 FM 🌐 Guadalajara 🖱️ radioarrebato.net 🗓️ SAB y DOM 18:30h Onda Cabanillas 107.0 FM 🌐 Cabanillas (GU) 🖱️ aytocabanillas.org 🗓️ MIE 21:00h
New music this week from SKYDA, Denis Airwave, Davey Asprey, Coast 2 Coast, Paul Todd, Pierre Pienaar, Aly & Fila, Lostly, TrancEye, F.G. Noise, Jue and many more. Choose your player
Join us on The Second Shift Podcast as we sit down with JuE Wong, a true legend in the beauty industry. From a background in finance, JuE defied the odds to become a CEO not once, but five times. In this episode, she shares invaluable insights on the art of career shifting, the importance of tenacity and patience, setting big goals and challenging yourself, reframing fear, and the power of networking. Whether you're looking to make a bold career move or simply seeking motivation to chase your dreams, JuE's journey and wisdom will leave you inspired and ready to take on the world.For more, you can follow the show on:Instagram TikTok & Youtube!Produced by Peoples Media Hosted on Acast. See acast.com/privacy for more information.
«Los soneros ganaban cada vez más partidarios en la capital.... Se habían entregado en cuerpo y alma a una verdadera fiebre de salsa.... Celebraban sus conciertos en todas partes. Su música se había puesto de moda no sólo en los cafetines de los barrios pobres, sino que se escuchaba ahora en los bares y las discotecas más elegantes de la ciudad, donde, para disgusto de los dirigentes del partido, ésta había ya casi aniquilado el rock.... »Candelario encontraba espantosa aquella música, pero no podía dejar de admirar el valor de sus ejecutantes.... Se alegraba de que sus compatriotas, si bien no tenían el valor de luchar por la independencia, en su música y en sus cantos sí se atrevieran a hacerlo.... »A poco de comenzada aquella locura, Candelario recibió una llamada telefónica confidencial. En el partido varios oficiales de alto rango se encontraban preocupados por el fenómeno de aquellos conciertos.... »—¿Me escucha, Candelario? [—le dijo una voz ronca e impersonal—].... Su primer deber de hoy en adelante será... evitar que esos conciertos se sigan celebrando. Así que meta a los soneros en cintura, si no quiere verse muy pronto, no sólo destituido como capitán, sino expulsado para siempre ignominiosamente de la tropa. »Candelario colgó molesto el receptor. Le parecía increíble que, bajo los pintorescos atuendos de los salseros, se ocultasen elementos políticamente sediciosos. La salsa, a más de esto, bien que grosera y de mal gusto (Candelario rehusaba considerarla música), era ya el modus vivendi de gran parte de la población, y coartarla sería injusto, además de prácticamente imposible. Aquellos sentimientos de conmiseración, sin embargo, pasaron a segundo plano en cuanto Candelario consideró las consecuencias de rehusarse a poner en efecto aquella orden.... »Haciendo, por lo tanto, de tripas corazón, al día siguiente organizó varias expediciones punitivas a los arrabales.... Llevado a cabo el propósito del partido, y devueltos a sus tugurios los malhechores con las cabezas hendidas y las costillas rotas, el silencio volvió a reinar una vez más supremo a lo largo de los farallones embestidos por el Atlántico de la antigua capital de San Juan.»1 ¡Con razón que a la escritora puertorriqueña Rosario Ferré —hija del estadista Luis A. Ferré, quien en su ilustre carrera llegó a ser gobernador y Presidente del Senado de Puerto Rico— le fue otorgado en 1986, en la Feria del Libro de Frankfurt, el Premio Liberatur por Maldito amor, libro compuesto de cuentos como este que lleva por título «La extraña muerte del Capitancito Candelario»! En la pluma de la ingeniosa Ferré, el pueblo boricua bien pudo haberse lamentado, junto con el pueblo de Israel, diciendo: «No se escucha ya la música de los jóvenes. En nuestro corazón ya no hay gozo; la alegría de nuestras danzas se convirtió en tristeza.»2 Menos mal que, a diferencia de los dirigentes políticos de esa obra ficticia, Dios el Señor, que nos creó con la capacidad de concebir un sinnúmero de géneros musicales y de disfrutar de ellos, no coarta ni limita nuestro libre albedrío en este gusto. Más bien, nos anima a que aplaudamos con Él la canción de Débora, que dice: «¡Escuchen, gobernantes!... Cantaré al Señor; tocaré música al... Dios de Israel.»3 Carlos ReyUn Mensaje a la Concienciawww.conciencia.net 1 Rosario Ferré, La extraña muerte del Capitancito Candelario (Barcelona: Plaza y Janés, 2002), pp. 58‑65. 2 Lm 5:14,15 3 Jue 5:3
This week on the Underpowered Hour, we've got a lot of business to catch up on! First up, DriveTribe has done a video about our friend Julian Schoolheifer's restoration of the very first production Land Rover, JUE 477. If you haven't listened to our interview with Julien, be sure to go back a few episodes and check out our replay to get the whole story. Link below to the video we talk about. Next up, there's a unique Red Camel Trophy car up on Bring a Trailer; the guys recorded this a few hours before the auction closed, so Ike and Steve debate whether the fact that it is red helps or hinders the collectible nature of the vehicle. (Check out the BAT listing below, and click through the comments to find out what happened when the auction closed). And word on the street is that a new, mallet, all electric Defender has been confirmed for 2027. Will it be called Defender Sport? Why not, there's already a Range Rover Sport and a Discovery Sport. Seems fitting, even if Bronco has jumped on that bandwagon too. Then, we've got a favorite segment we call “Love It, Can't Have It”, and this time we're drooling over the German market Surf Defender in coveted Marine Blue. Consider this our official petition to make that color available in the rest of the world. Who knew that the luxury SUV market in Germany was synonymous with surfing?
Classic Episode Replay from February of 2022. This week Ike and Steve give some quick workshop updates before talking to Julian Shoolheifer the man in charge of the restoration of production Land Rover 001 JUE 477.
On this episode, Liz sits down with CEO of hair care company Olaplex, JuE Wong to discuss how she started her career as a commodities trader and rose to the top of the haircare industry. JuE shares the challenges she faced trying to raise her children while also trying to grow in the business world. JuE later reveals how she overcame instances of harassment in the workplace, the death of her husband, and a massive pay cut that all contributed to her immense success at Olaplex. Follow Liz on Twitter: @LizClaman Learn more about your ad choices. Visit megaphone.fm/adchoices
(Víspera del Día de San Juan Bautista) Las mujeres que viven en las riberas del río Magdalena en los departamentos del Tolima y Huila, Colombia, aprovechan las fiestas de San Juan Bautista para hacer diversas pruebas con relación al amor. En la víspera de San Juan plantan un diente de ajo, las solteras para saber si de veras las ama el novio, y las casadas para saber lo mismo acerca del esposo. Si al amanecer el diente de ajo ha germinado, el hombre está realmente enamorado. Algunas solteras ponen el diente de ajo debajo de la cama; si al día siguiente germina, se casarán ese mismo año. Otras jóvenes solteras en la víspera de San Juan se miran en el espejo: si aparece el rostro de un hombre, habrá matrimonio; si aparece un ataúd, habrá muerte segura; y si aparece el diablo, habrá condenación. Algunas esperan hasta muy temprano el día de San Juan para mirarse en el espejo, también con la esperanza de ver a su futuro esposo allí reflejado; pero el espejo tiene que haber pasado en cruz por una hoguera. Las más pacientes se miran la noche de San Juan, no en un espejo sino en un arroyo o fuente de agua, esperando que en el agua aparezca una de dos cosas: o la imagen del futuro esposo, o la de los dos juntos.1 A todos nos interesa conocer la voluntad de Dios, especialmente con relación a las decisiones más importantes de la vida. Y una de las formas más ingeniosas de descifrarla es la que emplean aquellas mujeres para saber con quién se han de casar. Pero ese método no es original; se remonta a la época de los jueces bíblicos. Uno de ellos, el libertador Gedeón, se atrevió a someter a prueba la voluntad de Dios. Dios le había dicho que iba a usarlo para salvar de sus enemigos a Israel. Pero Gedeón tenía sus dudas, así que usó un vellón de lana para cerciorarse de la voluntad divina. Dos veces lo tendió en el suelo, la primera con la condición de que el vellón amaneciera mojado por el rocío y que toda la tierra alrededor quedara completamente seca, y la segunda a la inversa, es decir, de que el vellón amaneciera seco y que toda la tierra quedara cubierta de rocío. Con esos dos «milagritos» quedaría satisfecho de que era la voluntad de Dios. En efecto, así sucedió, y pasó a la historia como «el método del vellón».2 Dios es tan «buena gente» que a veces nos complace cuando quisiera más bien que mostráramos fe en su voluntad expresa, la cual lo complace a Él. ¿Y qué voluntad es ésa? Que todos seamos salvos y lleguemos a conocer la verdad de que hay un solo mediador entre Dios y los hombres, Jesucristo, que se hizo hombre y dio su vida como rescate por todos.3 Dios no quiere la condenación ni la muerte sino la salvación y la vida eterna para cada uno de nosotros.4 Él nos desea lo mejor. Lo único que tenemos que hacer es aceptarlo. Dejémonos de «vellones» y sometámonos a las únicas condiciones que de veras nos favorecen. Carlos ReyUn Mensaje a la Concienciawww.conciencia.net 1 Javier Ocampo López, Supersticiones y agüeros colombianos (Bogotá: El Áncora Editores, 1989), pp. 80-81,207. 2 Jue 6:37-40 3 1Ti 2:4,5 4 Jn 3:16-17
It's This Week in Bourbon for Jue 9th 2023. Virginia liquor officials said they're taking steps to automate the random lottery process, the third annual release of Russell's Reserve 13-Year-Old Bourbon , and the launch of Hardin's Creek The Kentucky Series, 3 different 17-year-old Bourbons.Show Notes: Virginia liquor officials said they're taking steps to automate the random lottery process Two comedians who named their Scotch whisky after their on-screen characters have won a trademark dispute against Jack Daniel's Sean "Diddy" Combs sues Diageo Sean 'Diddy' Combs has launched Diddy Direct Barrel Global announces the launch of its new barrel ownership service Independent Stave Company has purchased 8,016 forested acres near Somerset KY Mystic Galactic Bourbon has announced the selection of an orbiter vendor The release of Bib & Tucker Double Char Bourbon Dancing Goat Presents series, “Quirky & Humble.” Bardstown Bourbon Company will soon release Discovery Series #10 That Boutique-y Whisky Company is shining a light on American whiskey in its latest collection Woodford Reserve has released Woodford Reserve Batch Proof Third annual release of Russell's Reserve 13-Year-Old Bourbon Launch of Hardin's Creek The Kentucky Series, 3 different 17-year-old Bourbons @barrelglobal @independentstavecompany @mysticfarmdistillery @bibandtuckerbourbon @dancinggoatdistillery @bardstownbourbonco @boutiqueywhisky @woodfordreserve @russellsreservebourbon @hardinscreek Support this podcast on Patreon
"You know, I thought, I know about your podcast and I'm really thinking about what I can contribute in. It's really quite numerous. And so as I said, very little hereditary and so most of it is environmental. So one thing I want to say, it's tangential to your question, but I don't want it to be lost. It is family history and non-hereditary because we also share environments, share homes, maybe sometimes workplaces, and so it's not always that there's a gene." -Melanie Palomares I have had episodes to talk about what makes a home healthy in comparison to home being “green.” I would say most of us who are interested in “green homes” would probably want our homes to be healthy. So I wanted to talk to a medical professional who can give a perspective from the medical standpoint of prevention. What is it that we should all be aware of so that we know our homes are a place of nourishment and healing. Today, I have a guest named Melanie Palomares. She is an MD-MS. She's affectionately known as Dr. Mel as a preventive oncologist and founder of Cancer Prevention Movement. We discussed the various environmental factors that can contribute to cancer, including pollution, cleaning products, water and air quality., and exposure to EMS. We also talked about the importance of awareness and prevention, such as using filters and detectors, and making lifestyle changes to reduce exposure to harmful substances. Melanie offers various cancer prevention strategies including the importance of diet, exercise, and environmental factors. Jue 4 is a National Cancer Survivors' Day, which celebrates cancer survivors and highlights the need for prevention. Melanie's foundation: https://canpreventmovement.org/
Veteran actor Francis Jue stars in the Audible Original production of Good Enemy by the remarkable young playwright Yilong Liu. Jue plays Howard, the immigrant Chinese American father of a young adult daughter who has grown tired of trying to get him to share about his past. Why has he always been so secretive? What will it take for him to take his daughter into his confidence?
According to a report by Yale University, a person's hair and hairstyle impact not only our self-image but also the impression of others about us. Throughout the decades, society and media have inculcated the image of "perfect hair" as free-flowing, shiny, and tangle-free. However, this is definitely a false presentation of the realities of hair. The American Hair Research Society explains that an array of hair disorders and issues plague the nation, including hair loss (such as autoimmune alopecia areata and stress-derived telogen effluvium) and hair shaft defects (fragile hair, frizziness, coarseness, split ends).We are joined today by JuE Wong, the CEO and President of OLAPLEX since 2020, a global senior executive, and a transformative beauty industry leader. Born and raised in Singapore, JuE received her BA in International Economics and Political Science from The Australian National University in 1987 with an exchange scholarship at UCLA. Throughout the years, she has then progressed to be the revolutionary Global Director and President of brands such as Elizabeth Arden, Moroccanoil, Obagi, StriVectin, Astral Brands, Murad, Perricone MD, ZO Skin Health, and PepsiCo. With all her experience, she also serves as the Board Member for companies like the American Heart Association, YMCA of Greater New York, Committee of 200 (C200), and Cosmetic Executive Women (CEW). She has been recently listed on Forbes 5o Over 50 and has been awarded the Gold Stevie Award for Female Executive of the Year, the Beauty Independent Beacon Award for Brand Builder of the Year, and the Innocos Leader of Change.Livestream Air Date: August 4, 2022JuE Wong: IG @juewong888 & OLAPLEXFriends of Franz: IG @friendsoffranzpod & FB @friendsoffranzpodChristian Franz (Host): IG @chrsfranz & YT Christian FranzThankful to the season's brand partners: Clove, BETR Remedies, Eko, Lumify, RescueMD, Medical School for Kids, Your Skincare Expert, Twrl Milk Tea
Episode Notes Hotel companies have gotten better in recent years at reporting their environmental performances amid their push to reduce carbon emissions. However, Skift Research's latest report reveals hotel brands still have blind spots in their reporting, especially the performance of their franchised hotels. Skift Research investigated the environmental performance of the world's six largest hotel companies. Senior Research Analyst Wouter Geerts writes all companies need to do a better job of measuring and reporting their so-called scope 3 emissions. Greenhouse gas emissions are divided into three scopes, and scope 3 includes emissions from franchised hotels. Geerts notes that some companies have more comprehensive scope 3 coverage than others. Wyndham, the largest franchise holder of the companies Skift Research investigated, has very little scope 3 reporting. Prominent hotel brands have increasingly turned to franchising to help grow their portfolios. Next, major U.S. airlines are still struggling to make a complete recovery coming out of the pandemic. United Airlines and American Airlines are cutting flights due to issues such as pilot shortages and aircraft delivery delays, reports Edward Russell, editor of Airline Weekly, a Skift brand. United cited a pilot shortage as the reason it's ending flights to Erie, Pennsylvania in June. Russell notes that's a well-documented problem primarily affecting regional carriers. He adds that ongoing aircraft delivery delays have also made scheduling flights difficult. American suspended flights between Philadelphia and Madrid in May and Jue due to late deliveries of Boeing 787 jets. Russell also writes the reduced flight schedules don't come as a surprise, with Airbus and Boeing having consistently delivered planes late since last year. Finally, airports across the Middle East need an enormous amount of infrastructure improvement to help meet the rising demand for air travel. How much? $151 billion, reports Asia Editor Peden Doma Bhutia in this week's Middle East Travel Roundup newsletter. The push to improve the region's aviation infrastructure comes as Middle East airports are expected to handle more than 1 billion passengers by 2040. That's up from 405 million in 2019. Bhutia writes that several countries around the Middle East have already unveiled massive airport projects, including Saudi Arabia. Saudi officials are planning to build one of the world's largest airports.
================================================== ==SUSCRIBETEhttps://www.youtube.com/channel/UCNpffyr-7_zP1x1lS89ByaQ?sub_confirmation=1================================================== == DEVOCIÓN MATUTINA PARA MUJERES 2022“SIN MIEDOS NI CADENAS”Narrado por: Sirley DelgadilloDesde: Bucaramanga, ColombiaUna cortesía de DR'Ministries y Canaan Seventh-Day Adventist Church 30 DE NOVIEMBRE FUERA DE LUGAR“Después el ángel del Señor vino y se sentó debajo del gran árbol de Ofra que pertenecía a Joás, del clan de Abiezer. Gedeón, hijo de Joás, estaba trillando trigo en el fondo de un lagar para esconder el grano de las madianitas” (Juec. 6:11, NTV).Gedeón estaba completamente fuera de lugar. Al decirnos que él estaba trillando trigo en el fondo de un lagar, la Biblia pinta una imagen de desesperación absoluta. Es como si viéramos a una madre preparar una comida en el sótano de su casa, en medio de una guerra. Ella no prende la luz, no hace ruido; ni siquiera abre una ventana para que el aroma no atraiga la atención de sus enemigos. Los madianitas asediaban Israel. Tan pronto como los dorados granos de trigo eran recogidos o almacenados en los graneros, ellos aparecían para arrasarlo todo, como una plaga de langostas. Por eso encontramos a Gedeón completamente fuera de lugar, intentando hacer lo imposible: trillar trigo en el fondo de un lagar.En aquella época, el trigo se trillaba al aire libre, sacudiéndolo para que el viento se llevara la cáscara, y los granos pesados cayeran al suelo. Pero, como Gedeón está escondido en el fondo un lagar, ¡no había viento que lo ayude! Las prensas de uva de esa época se hacían cavando dos hoyos en la roca, uno encima del otro. Las uvas se aplastaban arriba y el jugo drenaba al de abajo. Gedeón estaba en el fondo del lagar, en el hoyo más profundo. Es justamente a este hombre, escondido en las entrañas de la roca, a quien el ángel del Señor le dice: "¡Guerrero valiente, el Señor está contigo!" (Jue. 6:12, NTV). Gedeón está completamente fuera de lugar; no porque está trillando en un lagar, sino porque cree que es demasiado pequeño y débil como para actuar. En ese encuentro, Dios le revela su verdadera identidad y le muestra su lugar.Muchas veces, como Gedeón, estamos fuera de lugar: presas de una identidad falsa, desperdiciando años, tratando de trillar trigo en el fondo de un lagar, pensando que somos demasiado débiles y que no hay nada que podamos hacer. Sin embargo, Dios nos encuentra, escondidas en lo profundo de nuestra inseguridad, y nos dice: “¡Guerrera valiente, el Señor está contigo!” Si aceptamos nuestra verdadera identidad y recibimos su llamado, nos enfrentaremos a los madianitas y destruirlos como si peleáramos contra un solo hombre. Dios te dio poder, fortaleza y sabiduría. Eres una guerrera valiente: esta es tu verdadera identidad. Sal del escondite, ¡es tiempo de luchar!Señor, cuando pienso que soy débil e insignificante, tú me recuerdas mi verdadera identidad, me recibes y me das una misión. Soy una guerrera valiente porque tú vas a mi lado.
On this episode, Liz sits down with CEO of hair care company Olaplex, JuE Wong to discuss how she started her career as a commodities trader and rose to the top of the haircare industry. JuE shares the challenges she faced trying to raise her children while also trying to grow in the business world. JuE later reveals how she overcame instances of harassment in the workplace, the death of her husband, and a massive pay cut that all contributed to her immense success at Olaplex. Follow Liz on Twitter: @LizClaman Learn more about your ad choices. Visit megaphone.fm/adchoices
This month on Episode 38 of Discover CircRes, host Cynthia St. Hilaire highlights original research articles featured in the Jue 24th, July 8th and July 22nd issues of the journal. This episode also features an interview with the 2022 BCBS Outstanding Early Career Investigator Award finalists, Dr Hisayuki Hashimoto, Dr Matthew DeBerge and Dr Anja Karlstadt. Article highlights: Nguyen, et al. miR-223 in Atherosclerosis. Choi, et al. Mechanism for Piezo1-Mediated Lymphatic Sprouting Kamtchum-Tatuene, et al. Plasma Interleukin-6 and High-Risk Carotid Plaques Li, et al. 3-MST Modulates BCAA Catabolism in HFrEF Cindy St. Hilaire: Hi, and welcome to Discover CircRes, the podcast of the American Heart Association's journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire, from the Vascular Medicine Institute at the University of Pittsburgh. And today I'm going to be highlighting articles from our June 24th, July 8th and July 22nd issues of Circulation Research. I'm also going to have a chat with the finalists for the 2022 BCBS Outstanding Early Career Investigator Award, Dr Hisayuki Hashimoto, Dr Matthew DeBerge and Dr Anja Karlstadt. Cindy St. Hilaire: The first article I want to share is from our June 24th issue and is titled, miR-223 Exerts Translational Control of Proatherogenic Genes in Macrophages. The first authors are My-Anh Nguyen and Huy-Dung Hoang, and the corresponding author is Katey Rayner and they're from the University of Ottawa. A combination of cholesterol accumulation in the blood vessels and subsequent chronic inflammation that's derived from this accumulation drive the progression of atherosclerosis. Unfortunately, current standard medications tackle just one of these factors, the cholesterol. And this might explain why many patients on such drugs still have vascular plaques. In considering treatments that work on both aspects of the disease, meaning lipid accumulation and inflammation, this group investigated the micro RNA 223 or miR-223, which is a small regulatory RNA that has been shown to suppress expression of genes involved in both cholesterol uptake and inflammatory pathways in both liver and immune cells. Cindy St. Hilaire: The team showed that mouse macrophages deficient in miR-223, exhibited increased expression of pro-inflammatory cytokines and reduced cholesterol efflux compared with control cells. Overexpression of miR-223 had the opposite effects. Furthermore, atherosclerosis prone mice, whose hematopoietic cells lacked miR-223, had worse atherosclerosis with larger plaques and higher levels of pro-inflammatory cytokines than to control animals with normal levels of miR-223. These findings highlight miR-223's dual prompt, antiatherogenic action, which could be leveraged for future therapies. Cindy St. Hilaire: The second article I want to share is from our July 8th issue of Circulation Research and is titled, Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymph Expansion. The first author is Dongwon Choi and the corresponding author is Young-Kwon Hong, and they're from UCLA. As well as being super highways for immune cells, lymph vessels are drainage channels that help maintain fluid homeostasis in the tissues. This network of branching tubes grows as fluids begin to flow in the developing embryo. This fluid flow induces calcium influx into the lymphatic endothelial cells, which in turn promotes proliferation and migration of these cells, leading to the sprouting of lymph tubules. But how do LECs, the lymphatic endothelial cells, detect fluid flow in the first place? Piezo1 is a flow and mechanosensing protein known for its role in blood vessel development and certain mutations in Piezo1 cause abnormal lymphatic growth in humans. Cindy St. Hilaire: This script found that Piezo1 is expressed in the embryonic mouse LECs and that the suppression of Piezo1 inhibits both flow activated calcium entry via the channel ORAI1, as well as downstream target gene activation. Overexpression of Piezo1, by contrast, induced the target genes. The team went on to show that mice lacking either Piezo1 or ORAI1 had lymphatic sprouting defects and that pharmacological activation of Piezo1 in mice enhanced lymphogenesis and prevented edema after tail surgery. Together, the results confirmed Piezo1's role in flow dependent lymphatic growth and suggest it might be a target for treating lymphedema. Cindy St. Hilaire: The third article I want to share is also from our July 8th issue and is titled, Interleukin-6 Predicts Carotid Plaque Severity, Vulnerability and Progression. The first and corresponding author of this study is Joseph Kamtchum-Tatuene from University of Alberta. Excessive plasma cholesterol and systemic inflammation are contributing factors in atherosclerosis. While traditional remedies have been aimed at lowering patient's lipid levels, drugs that tackle inflammation are now under investigation, including those that suppress Interleukin-6, which is an inflammatory cytokine implicated in the disease. Focusing on carotid artery disease, this group conducted a prospective study to determine whether IL-6 levels correlated with disease severity. 4,334 individuals were enrolled in the cardiovascular health study cohort. They had their blood drawn and ultrasounds taken at the start of the study and five years later. This group found IL-6 was robustly correlated with and predicted plaque severity independent of other cardiovascular risk factors. This study also determined that an IL-6 blood plasma level of 2.0 picograms/mls, identified individuals with the highest likelihood of plaque, vulnerability and progression. This threshold value could be used to select patients who might benefit from novel IL-6 lowering medications. Cindy St. Hilaire: The last article I want to share is from our July 22nd issue of Circulation Research and is titled, Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure. The first author is Zhen Li, and the corresponding author is David Lefer from Louisiana State University. Hydrogen sulfide, or H2S, is a compound that exerts mitochondrial specific actions that include the preservation of oxidative phosphorylation, mitochondrial biogenesis and ATP synthesis, as well as inhibiting cell death. 3-mercaptopyruvate sulfurtransferase, or 3-MST, is a mitochondrial H2S producing enzyme, whose functions in cardiovascular disease are not fully understood. Cindy St. Hilaire: This group investigated the global effects of 3-MST deficiency in the setting of pressure overload induced heart failure. They found that 3-MST was significantly reduced in the myocardium of patients with heart failure, compared with non failing controls. 3-MST knockout mice exhibited increased accumulation of branch chain amino acids in the myocardium, which was associated with reduced myocardial respiration and ATP synthesis, exacerbated cardiac and vascular dysfunction, and worsened exercise performance, following transverse aortic constriction. Restoring myocardial branched-chain amino acid catabolism, or administration of a potent H2S donor, ameliorated the detrimental effects of 3-MST deficiency and heart failure with reduced injection fraction. These data suggest that 3-MST derived mitochondrial H2S, may play a regulatory role in branch chain amino acid catabolism, and mediate critical cardiovascular protection in heart failure. Cindy St. Hilaire: Today, I'm really excited to have our guests, who are the finalists for the BCVS Outstanding Early Career Investigator Awards. Welcome everyone. Hisayuki Hashimoto: Thank you. Anja Karlstaedt: Hi. Hisayuki Hashimoto: Hi. Matthew DeBerge: Hello. Thank you. Cindy St. Hilaire: So the finalists who are with me today are Dr Hisayuki Hashimoto from Keio University School of Medicine in Tokyo, Japan, Dr Matthew Deberge from Northwestern University in Chicago and Dr Anja Karlstaedt from Cedar Sinai Medical Center in LA. Thank you again. Congratulations. And I'm really excited to talk about your science. Hisayuki Hashimoto: Thank you. Yes. Thanks, first of all for this opportunity to join this really exciting group and to talk about myself and ourselves. I am Hisayuki Hashimoto, I'm from Tokyo, Japan. I actually learned my English... I went to an American school in a country called Zaire in Africa and also Paris, France because my father was a diplomat and I learned English there. After coming back to Japan, I went to medical school. During my first year of rotation, I was really interested in cardiology, so I decided to take a specialized course for cardiology. Then I got interested in basic science, so I took a PhD course, and that's what brought me to this cardiology cardiovascular research field. Matthew DeBerge: So I'm currently a research assistant professor at Northwestern University. I'm actually from the Chicagoland area, so I'm really excited to welcome you all to my hometown for the BCVS meeting. Cindy St. Hilaire: Oh, that's right. And AHA is also there too this year. So you'll see a lot of everybody. Matthew DeBerge: I guess I get the home field advantage, so to speak. So, I grew up here, I did my undergrad here, and then went out in the east coast, Dartmouth College in New Hampshire for my PhD training. And actually, I was a viral immunologist by training, so I did T cells. When I was looking for a postdoctoral position, I was looking for a little bit of something different and came across Dr Edward Thorpe's lab at Northwestern university, where the interest and the focus is macrophages in tissue repair after MI. So, got into the macrophages in the heart and have really enjoyed the studies here and have arisen as a research assistant professor now within the Thorpe lab. Now we're looking to transition my own independent trajectory. Kind of now looking beyond just the heart and focusing how cardiovascular disease affects other organs, including the brain. That's kind of where I'm starting to go now. Next is looking at the cardiovascular crosstalk with brain and how this influences neuroinflammation. Anja Karlstaedt: I am like Hisayuki, I'm also a medical doctor. I did my medical training and my PhD in Berlin at the Charité University Medicine in Berlin, which is a medical faculty from Humboldt University and Freie University. II got really interested in mathematical modeling of complex biological systems. And so I started doing my PhD around cardiac metabolism and that was a purely core and computationally based PhD. And while I was doing this, I got really hooked into metabolism. I wanted to do my own experiments to further advance the model, but also to study more in crosstalk cardiac metabolism. I joined Dr Heinrich Taegteyer lab at the University of Texas in the Texas Medical Center, and stayed there for a couple of years. And while I was discovering some of the very first interactions between leukemia cells and the heart, I decided I cannot stop. I cannot go back just after a year. I need to continue this project and need to get funding. And so after an AHA fellowship and NIHK99, I am now here at Cedars Sinai, an assistant professor in cardiology and also with a cross appointment at the cancer center and basically living the dream of doing translational research and working in cardio-oncology. Cindy St. Hilaire: Great. So, Dr Hashimoto, the title of your submission is, Cardiac Reprogramming Inducer ZNF281 is Indispensable for Heart Development by Interacting with Key Cardiac Transcriptional Factors. This is obviously focused on reprogramming, but why do we care about cardiac reprogramming and what exactly did you find about this inducer ZNF281? Hisayuki Hashimoto: Thank you for the question. So, I mean, as I said, I'm a cardiologist and I was always interested in working heart regeneration. At first, I was working with pluripotent stem cells derived cardiomyocyte, but then I changed my field during my postdoc into directly programming by making cardiomyocyte-like cells from fiberblast. But after working in that field, I kind of found that it was a very interesting field that we do artificially make a cardiomyocyte-like cell. But when I dissected the enhanced landscape, epigenetic analysis showed that there are very strong commonalities between cardiac reprogramming and heart development. So I thought that, hey, maybe we can use this as a tool to discover new networks of heart development. And the strength is that cardiac reprogramming in vitro assay hardly opens in vivo assay, so it's really time consuming. But using dark programming, we can save a lot of time and money to study the cardiac transitional networks. And we found this DNF281 from an unbiased screen, out of 1000 human open reading frames. And we found that this gene was a very strong cardiac reprogramming inducer, but there was no study reporting about any functioning heart development. We decided to study this gene in heart development, and we found out that it is an essential gene in heart development and we were kind of able to discover a new network in heart development. Cindy St. Hilaire: And you actually used, I think it was three different CRE drivers? Was that correct to study? Hisayuki Hashimoto: Ah, yes. Yeah. Cindy St. Hilaire: How did you pick those different drivers and what, I guess, cell population or progenitor cell population did those drivers target? Hisayuki Hashimoto: So I decided to use a mesodermal Cre-driver, which is a Mesp1Cre and a cardiac precursor Cre-driver, which is the Nkx2-5 Cre and the cardiomyocyte Cre, which is the Myh6-Cre. So three differentiation stages during heart development, and we found out that actually, DNF281 is an essential factor during mesodermal to cardiac precursor differentiation state. We're still trying to dig into the molecular mechanism, but at that stage, if the DNF281 is not there, we are not able to make up the heart. Cindy St. Hilaire: That is so interesting. Did you look at any of the strains that survived anyway? Did you look at any phenotypes that might present in adulthood? Is there anything where the various strains might have survived, but then there's a kind of longer-term disease implicating phenotype that's observed. Hisayuki Hashimoto: Well, thank you for the question. Actually, the mesodermal Cre-driver knocking out the DNF281 in that stage is embryonic lethal, and it does make different congenital heart disease. And they cannot survive until after embryonic day 14.5. The later stage Nkx2-5 Cre and Myh6-Cre, interestingly, they do survive after birth. And then in adult stage, I did also look into the tissues, but the heart is functioning normally. I haven't stressed them, but they develop and they're alive after one year. It looks like there's really no like phenotype at like the homeostatic status. Cindy St. Hilaire: Interesting. So it's kind of like, once they get over that developmental hump, they're okay. Hisayuki Hashimoto: Exactly. That might also give us an answer. What kind of network is important for cardiac reprogramming? Cindy St. Hilaire: So what are you going to do next? Hisayuki Hashimoto: Thank you. I'm actually trying to dig into the transitional network of what kind of cardiac transitional network the ZNF281 is interacting with, so that maybe I can find a new answer to any etiology of congenital heart disease, because even from a single gene, different mutation, different variants arise different phenotypes in congenital heart disease. Maybe if I find a new interaction with any key cardiac transitional factors, maybe I could find a new etiology of congenital heart disease phenotype. Cindy St. Hilaire: That would be wonderful. Well, best of luck with that. Congratulations on an excellent study. Hisayuki Hashimoto: Thank you. Cindy St. Hilaire: Dr DeBerge, your study was titled, Unbiased Discovery of Allograft Inflammatory Factor-1 as a New and Critical Immuno Metabolic Regulatory Node During Cardiac Injury. Congrats on this very cool study. You were really kind of focused on macrophages in myocardial infarction. And macrophages, they're a Jeckel Hyde kind of cell, right? They're good. They're bad. They can be both, almost at the same time, sometimes it seems like. So why were you interested in macrophages particularly in myocardial infarction, and what did you discover about this allograft inflammatory factor-1, or AIF1 protein? Matthew DeBerge: Thank you. That's the great question. You really kind of alluded to why we're interested in macrophages in the heart after tissue repair. I mean, they really are the central mediators at both pro-inflammatory and anti-inflammatory responses after myocardial infarction. Decades of research before this have shown that inflammation has increased acutely after MI and has also increased in heart failure patients, which really has led to the development of clinical efforts to target inflammatory mediators after MI. Now, unfortunately, the results to target inflammation after MI, thus far, have been modest or disappointing, I guess, at worst, in the respect that broadly targeting macrophage function, again, hasn't achieved results. Again, because these cells have both pro and anti-inflammatory functions and targeting specific mediators has been somewhat effective, but really hasn't achieved the results we want to see. Matthew DeBerge: I think what we've learned is that the key, I guess, the targeting macrophage after MI, is really to target their specific function. And this led us to sort of pursue novel proteins that are mediating macrophage factor function after MI. To accomplish this, we similarly performed an unbiased screen collecting peri-infarct tissue from a patient that was undergoing heart transplantation for end stage heart failure and had suffered an MI years previously. And this led to the discovery of allograft inflammatory factor-1, or AIF1, specifically within cardiac macrophages compared to other cardiac cell clusters from our specimen. And following up with this with post-mortem specimens after acute MI to show that AIF1 was specifically increased in macrophages after MI and then subsequently then testing causality with both murine model of permanent inclusion MI, as well as in vitro studies using bone marrow drive macrophages to dig deeper mechanistically, we found that AIF1 was crucial in regulating inflammatory programing macrophages, which ultimately culminated in worse in cardiac repair after MI. Cindy St. Hilaire: That's really interesting. And I love how you start with the human and then figure out what the heck it's doing in the human. And one of the things you ended up doing in the mouse was knocking out this protein AIF1, specifically in macrophage cells or cells that make the macrophage lineage. But is this factor in other cells? I was reading, it can be intracellular, it can be secreted. Are there perhaps other things that are also going on outside of the macrophage? Matthew DeBerge: It's a great question. First, I guess in terms of specificity, within the hematopoietic compartment, previous studies, as well as publicly available databases, have shown that AIF1 is really predominantly expressed within macrophages. We were able to leverage bone marrow chimera mice to isolate this defect to the deficiency to macrophages. But you do bring up a great point that other studies have shown that AIF1 may be expressed in other radio-resistant cell populations. I mean, such as cardiomyocytes or other treatable cells within the heart. We can't completely rule out a role for AIF1 and other cell populations. I can tell you that we did do the whole body knockout complementary to our bone marrow hematopoetic deficient knockouts, and saw that deficiency of AIF1 within the whole animal, recapitulate the effects we saw within the AIF1 deficiency within hematopoietic department. Matthew DeBerge: It was encouraging to us that, again, the overall role of AIF1 is pro-inflammatory after MI. Cindy St. Hilaire: I mean, I know it's early days, but is there a hint of any translational potential of these findings or of this protein? Matthew DeBerge: Yeah, I think so. To answer your question, we were fortunate enough to be able to partner with Ionis that develops these anti-sensible nucleotides so that we could specifically target AIF1 after the acute phase during MI. We saw that utilizing these anti-sensible nucleotides to deplete AIF1, again, within the whole mouse, that we were able to reduce inflammation, reduce in heart size and preserve stock function. I think there really is, hopefully a therapeutic opportunity here. And again, with it being, perhaps macrophage specific is, even much more important as we think about targeting the specific function of these cells within the heart. Cindy St. Hilaire: Very cool stuff. Dr Karlstaedt, the title of your submission is, ATP Dependent Citrate Lyase Drives Metabolic Remodeling in the Heart During Cancer. So this I found was really interesting because you were talking about, the two major killers in the world, right? Cardiovascular disease and cancer, and you're just going to tackle both of them, which I love. So obviously this is built on a lot of prior observations about the effects of cancer on cardiac metabolic remodeling. Can you maybe just tell us a little bit about what is that link that was there and what was known before you started? Anja Karlstaedt: Yeah. Happy to take that question. I think it's a very important one and I'm not sure if I will have a comprehensive answer to this, because like I mentioned at the beginning, cardio-oncology is a very new field. And the reason why we are starting to be more aware of cancer patients and their specific cardiovascular problems is because the cancer field has done such a great job of developing all these new therapeutics. And we have far more options of treating patients with various different types of cancers in particular, also leukemias, but also solid tumors. And what has that led to is an understanding that patients survive the tumors, but then 10, 20 years later, are dying of cardiovascular diseases. Those are particular cardiomyopathies and congestive heart failure patients. What we are trying, or what my lab is trying to do, is understanding what is driving this remodeling. And is there a way that we can develop therapies that can basically, at the beginning of the therapy, protect the heart so that this remodeling does not happen, or it is not as severe. Anja Karlstaedt: Also, identifying patients that are at risk, because not every tumor is created equally and tumors are very heterogeneous, even within the same group. To get to your question, what we found is, in collaboration actually with a group at Baylor College of Medicine, Peggy Goodell's group, who is primarily working on myeloid malignancies, is that certain types of leukemias are associated with cardiomyopathies. And so when they were focusing on the understanding drivers of leukemia, they noticed that the hearts of these animals in their murine models are enlarged on and actually developing cardiomyopathies. And I joined this project just very early on during my postdoc, which was very fortunate and I feel very lucky of having met them. What my lab is now studying here at Cedars is how basically those physiological stress and mutations coming from the tumors are leading to metabolic dysregulation in the heart and then eventually disease. Anja Karlstaedt: And we really think that metabolism is at the center of those disease progressions and also, because it's at the center, it should be part of the solution. We can use it as a way to identify patients that are at risk, but also potentially develop new therapies. And what was really striking for us is that when we knock down ACLY that in a willdtype heart where the mouse doesn't have any tumor disease, ACLY actually is critically important for energy substrate metabolism, which seems counterintuitive, because it's far away from the mitochondria, it's not part of directly ADP provision. It's not part of the Kreb cycle. But what we found is that when we knock it out using a CRISPR-Cas9 model, it leads to cardiomyopathy and critically disrupts energy substrate metabolism. And that is not necessarily the case when the mouse has leukemia or has a colorectal cancer, which upregulated in the beginning, this enzyme expression. And so we have now developed models that show us that this could be potentially also therapeutic target to disrupt the adverse remodeling by the tumor. Cindy St. Hilaire: That is so interesting. So one of the things I was thinking about too is we know that, I mean, your study is showing that, the tumor itself is causing cardiac remodeling, but we also know therapies, right? Radiation, chemotherapy, probably some immune modulatory compounds. Those probably do similar, maybe not exactly similar, but they also cause, adverse cardiac remodeling. Do you have any insights as to what is same and what is different between tumor driven and therapy driven adverse remodeling? Anja Karlstaedt: So we do not know a lot yet. It's still an open question about all the different types of chemotherapeutics, how they are leading to cardio toxicities. But what we know, at least from the classic anti-cyclic treatments, is right now at the core, the knowledge is that this is primarily disrupting cardiac mitochondrial function. And through that again, impairing energy provision and the interaction, again, with the immune system is fairly unknown, but we know through studies from Kathryn Moore and some very interesting work by Rimson is that myocardial infarction itself can lead to an increase in risk for tumor progression. And what they have shown as independent of each other, is that the activation of the immune system in itself can lead to an acceleration of both diseases, both the cardiac remodeling, and then also the tumor disease. We don't fully understand which drivers are involved, but we do know that a lot of the cardiomyopathies on cardiotoxicities that are chemotherapeutically driven, all have also metabolic component. Cindy St. Hilaire: Nice. Thank you. When I prepare for these interviews, I obviously read the abstracts for the papers, but I found myself also Googling other things after I read each of your abstracts. It was a rabbit hole of science, which was really exciting. I now want to transition to kind of a career angle. You all are obviously quite successful, scientifically, at the bench, right? But now you are pivoting to a kind of completely opposite slash new job, right? That of, independent researcher. I would love to hear from each of you, if there was any interesting challenge that you kind of overcame that you grew from, or if there was any bit of advice that you wish you knew ahead of time or anything like that, that some of our trainee listeners and actually frankly, faculty who can pass that information onto their trainees, can benefit from. Anja Karlstaedt: I think the biggest challenge for me in transitioning was actually the pandemic. Because I don't know how it was for Hisa and Matt, but trying to establish a lab, but also applying for faculty position during a major global pandemic, is challenging is not quite something that I expected that would happen. And so I think saying that and looking more conceptually and philosophically at this as, you can prepare as much as you want, but then when life just kicks in and things happen, they do happen. And I think the best is to prepare as much as you can. And then simply go with the flow. Sometimes one of my mentors, Dave Nikon, mentioned that to me when I was applying for faculty positions, it's sometimes good to just go with the flow. And as a metabolism person, I absolutely agree. And there are some things that you can do as a junior investigator. Anja Karlstaedt: We need to have a good network. So just very important to have good mentors. I was blessed with have those mentors, Peggy Goodell's one of them, Heinrich Taegtmeyer was another. And now with this study that we are publishing, Jim Martin and Dave Nikon were incredible. Without them, this study wouldn't have been possible and I would not be here at Cedars. Anja Karlstaedt: You need to reach out to other people because those mentors have the experience. They have been through some of this before. Even if they have never had a major event, like COVID-19 in their life before, because none of us had before, they had other experiences and you can rely on them and they set you then up for overcoming these challenges. And the other thing I would say, is put yourself out there, go and talk to as many people as possible or set conferences, present a poster, not only talks. Don't be disappointed if you don't get a talk, posters are really great to build this network and find other people that you probably wouldn't have encountered and apply for funding. Just again, put yourself out there and try to get the funding for your research. Even if it's small foundations, it builds up over time and it is a good practice to then write those more competitive grants. Cindy St. Hilaire: Dr Hashimoto, would you like to go next? Hisayuki Hashimoto: Just my advice is that, could be like a culture of difference, but in east Asia, like in Japan, we were taught to, do not disturb people, don't interrupt people and help people. But I realized that I wasn't really good at asking for help. After I am still not like fully independent, but I do have my own group and I have to do grant writing. I still work at the bench and then have to teach grad students, doing everything myself. I just realized it's just impossible. I didn't have time. I need like 48 hours a day. Otherwise, you won't finish it. I just realized that I wasn't really good at asking for help. So my advice would be, don't hesitate to ask for help. It's not a shame. You can't do everything by just yourself. I think, even from the postdoc, even from grad school, I think, ask for help and then get used to that. And then of course, help others. And that is the way I think to probably not get overwhelmed and not stress yourself. Science should be something fun. And if you don't ask for help and if you don't help someone, I think you are losing the chance of getting some fun part from the science. Cindy St. Hilaire: That's great advice. I really like that, especially because I find at least, I started my lab seven years ago now. And I remember the first couple months/year, it was extremely hard to let go, right? Like I taught my new people how to do the primary cell culture we needed, but I was terrified of them doing it wrong or wasting money or making too many mistakes. But you realize, you got to learn to trust people. Like you said, you got to learn to ask for help. And sometimes that help is letting them do it. And you doing, you're being paid now to write grants and papers. That's a big brain, you're not paid to do the smaller things. That's really great advice. I like that. Thank you. Dr DeBerge, how about you? Matthew DeBerge: So I guess towards a bit of life advice, I think two obvious things is one, be kind, science is hard enough as it is. So I think we should try to lift each other up and not knock each other down. And along those lines as the others have alluded to as well, one of the mantras we sort of adapted on the lab, is a rising tide raises all ships, this idea that we can work together to elevate each other's science and really, again, collaborate. Towards the career side of things I'll just touch on, because I guess one thing I'll add, there's more than one path, I guess, to achieving your goals. I've been fortunate enough to have an NIH post-doctoral fellowship and had an AHA career development award, but I'm not a K99 recipient. Oftentimes, I think this is the golden ticket to getting the faculty job, so I'm trying to, I guess, buck trend, I just submitted an RO1. So fingers crossed that leads to some opportunity. Even beyond academia, I'm not certain how much everyone here is involved in science Twitter, it's really become a thing over the last couple years, but I think, kind of the elephant in the room is that academia, it's really hard on the trainees nowadays to have a living wage, to go through this. I mean, I'm really excited to see my, fellow finalists here are starting their own groups and stuff, but for many, that's not the reality for many, it's just not financially feasible. So I think, kind of keeping in mind that there's many, many alternative careers, whether it's industry, whether it's consulting, science writing, etcetera, going back to what Dr Hash says, find what you love and really pursue that with passion. Cindy St. Hilaire: I think it's something only, I don't know, five to 10% of people go into or rather stay in academia. And that means, 90 to 95% of our trainees, we need to prepare them for other opportunities, which I think is exciting, because it means it can expand our network for those of us in academia. Anja Karlstaedt: I think right now it's even worse because it's about 2% of old postdocs that are actually staying and becoming independent researchers, independent or tenure track or research track. And I think I second, as what Matt said, because I play cello. I do music as a hobby and people always ask me if I'm a musician. And at the beginning I felt like, no, of course not. I'm not like Yoyo Ma. I'm just playing, it's a hobby. And then I, that got me thinking. I was like, no, of course you are because there's so many different types. And what we need to understand is that scientists, like you are always a scientist. It doesn't matter if you are working at Pfizer or if you are working at a small undergrad institution and you're teaching those next generation scientists, you are still scientist and we all need those different types of scientists because otherwise, if everybody is just a soloist, you are never going to listen to symphony. You need those different people and what we need to normalize beyond having those different career paths, is also that people are staying in academia and becoming those really incredible resources for the institutions and labs, quite frankly, of being able to retain those technologies and techniques within an institution. And I think that's something to also look forward to, that even if you're not the PI necessarily, you're the one who is driving those projects. And I hope to pass this on at some point also to my trainees that they can be a scientist, even if they're not running a lab and they become an Institute director and that's also critically important. Cindy St. Hilaire: There's lots of ways to do science. Thank you all so much for joining me today. Either waking up at 5:00 AM or staying up past midnight, I think it is now in Japan or close to it. So Matt and I kind of made it out okay. It's like 8:00 or 9:00 AM. Matthew DeBerge: Thank you. Hisayuki Hashimoto: My apologies for this time zone difference. Cindy St. Hilaire: I'm very glad to make it work. Congratulations to all of you, your presentations. I forget which day of the week they are on at BCVS, but we are looking forward to the oral presentations of these and congratulations to all of you. You are amazing scientists and I know I'm really looking forward to seeing your future work so best of luck. Matthew DeBerge: Thank you. Hisayuki Hashimoto: Thank you. Anja Karlstaedt: Thank you so much. Cindy St. Hilaire: That's it for the highlights from the June 24th, July 8th and July 22nd issues of Circulation Research. Thank you for listening. Please check out the CircRes Facebook page and follow us on Twitter and Instagram with the handle at CircRes and hashtag Discover CircRes. Thank you to our guests. The BCVS Outstanding Early Career Investigator Award Finalists, Dr Hisayuki Hashimoto, Dr Matthew DeBerge and Dr Anja Karlstaedt. This podcast is produced by Ashara Ratnayaka, edited by Melissa Stoner and supported by the editorial team of Circulation Research. Some of the copy text for the highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire. And this is Discover CircRes, you're on the go source for the most exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association, 2022. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more information visit ahajournals.org.
While there are more female CEOs in beauty today than there ever has been, men still dominate the C-Suite and boardroom, at least the biggest companies. The women who have broken through the glass ceiling to reach the top of the organizational chart are using their influence to pave the way for others to follow in their footsteps. Kelly Kovack is joined this week by one of these women, JuE Wong, the CEO and Executive Board Member of Olaplex. Kelly talks to JuE about her impressive track record of scaling emerging brands and globalizing established ones. See omnystudio.com/listener for privacy information.
Glam & Grow - Fashion, Beauty, and Lifestyle Brand Interviews
Shortly after accepting her new role with Olaplex, CEO JuE Wong fearlessly took the brand public during the pandemic. Since then, Olaplex has continued to pave the way in bond-building technology.In today's episode, JuE gives insight into Olaplex's innovative approach to hair care and how partnering with hair care professionals has caused the brand to thrive. JuE also shares:The pros and cons of social mediaThe brand's method to managing and dissecting dataOlaplex's approach to navigating the supply chain and the residual effects of the pandemicTips on building a great leadership teamYou'll also hear about JuE's daily routine as she leads one of the largest independent hair care brands in the world.This episode is sponsored by AttentiveAttentive is a personalized text message marketing platform that lets you communicate with your customers in real-time, engage them with timely campaigns, and help your business drive revenue. Thousands of brands like CB2, Pura Vida, and Coach have created magical customer experiences and driven over 20% of their online revenue using Attentive-powered personalized text messages. And you, too, can turn SMS into one of your top-three revenue channels in just a few months. Visit attentivemobile.com/wavebreak to learn how you can try it for free.This episode is also brought to you by WavebreakLeading direct-to-consumer brands hire Wavebreak to turn email marketing into a top revenue driver.Most eCommerce brands don't email right... and it costs them. At Wavebreak, our eCommerce email marketing agency helps qualified stores recapture 6-7 figures of lost revenue each year.From abandoned cart emails to Black Friday campaigns, our best-in-class team of email specialists manage the entire process: strategy, design, copywriting, coding, and testing. All aimed at driving growth, profit, brand recognition, and most importantly, ROI.Curious if Wavebreak is right for you? Reach out at Wavebreak.co
Welcome to the Conversations with CommerceNext podcast, I'm your host Michael LeBlanc, and this podcast is brought to you in conjunction with CommerceNext and presented by Bloomreach.Having held leadership roles at some of the biggest prestige beauty brands such as Elizabeth Arden, Perricone MD, Stivectin and Moroccan Oil, JuE Wong is the perfect leader to take this cult brand to the next level, the phenomenon that is Olaplex.Olaplex is a rocket ship having grown 112% just in the last year after expanding from salons into retail and DTC. Fueled by the passion for the product, people and technology that is taking this brand to new heights, JuE shares with the CommerceNext community part of the elusive formula for triple-digit, sustainable growth and the potential new opportunities for the business.About JuECore competence in driving material growth in all channels and medium of growth. An early adopter of omni channel of sales, including social commerce and alternative media in digital and social.Below is a link to my online Resume:www.juewong888.wix.com/juewong ABOUT US: Scott SilvermanAn ecommerce veteran, Scott Silverman has been active in the industry since 1999 and is passionate about digital retail and the innovation driving the industry. Scott Silverman is the Co-Founder of CommerceNext. Previously, he spent 10 years as Executive Director of Shop.org where he launched the Shop.org Annual Summit. Scott co-invented “Cyber Monday” in 2005 and was the founder of Cybermonday.com in 2006, a shopping site that has generated more than $2.5 million for Shop.org's scholarship fund.Veronika SonsevVeronika Sonsev is the Co-Founder of CommerceNext. She also leads the retail practice for Chameleon Collective and is a contributor for Forbes on how to grow retail and ecommerce in the age of Amazon. Having spent the last 10+ years working with some of the largest retailers and direct-to-consumer brands, Veronika has intimate knowledge of the challenges facing retail and ecommerce today. She is also an advocate for women in business and founded the global non-profit mBolden, which is now part of SheRunsit. Michael LeBlanc is the Founder & President of M.E. LeBlanc & Company Inc and a Senior Advisor to Retail Council of Canada as part of his advisory and consulting practice. He brings 25+ years of brand/retail/marketing & eCommerce leadership experience, and has been on the front lines of retail industry change for his entire career. Michael is the producer and host of a network of leading podcasts including Canada's top retail industry podcast, The Voice of Retail, plus Global E-Commerce Tech Talks and The Food Professor with Dr. Sylvain Charlebois. You can learn more about Michael here or on LinkedIn.
Earned: Strategies and Success Stories From the Best in Beauty + Fashion
In Episode 46 of Earned, we sit down with a true industry leader: JuE Wong, CEO of Olaplex, a top-ranking haircare brand valued at $15 billion. We start the episode with JuE sharing her general leadership philosophies, as well as how her leadership style has evolved since her first executive role. We then explore the investments that JuE made when she joined Olaplex in January of 2020 that helped accelerate the brand's growth, before hearing how the company maintained its culture after quadrupling in size over the following two years. Next, JuE emphasizes the importance of omnichannel synergy between retail, professional, and DTC, and we learn how Olaplex supported its professional hairstylist community during the COVID shutdowns. Switching gears, we hear why JuE, who grew up in Singapore, wanted to move to the US, before JuE opens up about how the passing of her husband made her a more empathetic leader. To close the show, JuE shares how she wants to use her professional influence in the industry for good.
(Víspera del Día Internacional de la Mujer) «Su nombre y su rostro estarán ahora en uno de los salones del Salón Azul de la Asamblea Legislativa, pero ¿qué papel jugó en la historia salvadoreña esta mujer? Es considerada desde 1976 como una heroína de la Patria gracias a un decreto legislativo de ese entonces. Sin embargo, en cada 5 de noviembre que se conmemora el Primer Grito de Independencia su nombre no es mencionado en ningún acto alusivo ni conmemorativo.» Así comenzó El Metropolitano Digital el 25 de septiembre de 2014 su artículo titulado «¿Quién fue María Feliciana de los Ángeles Miranda?». «María Feliciana, junto a su hermana Manuela Miranda, fueron las encargadas de difundir el primer movimiento independentista en San Salvador que fue lanzado... aquel 5 de noviembre de 1811 —explicó el periódico digital salvadoreño—. Las hermanas difundieron la noticia del movimiento patriota en la campiña de Sensuntepeque, promoviendo un levantamiento general contra los realistas.... »Ahora, su valentía [ha sido] reconocida al develar su retrato en el Parlamento salvadoreño. “Hoy cumplimos con un nuevo acto de justicia. Hoy les dedicamos este tributo a las heroínas que estuvieron presentes en el proceso independentista”, dijo el presidente de la Asamblea, Sigfrido Reyes.»1 Según el reconocido historiador Carlos Cañas Dinarte, las hermanas Miranda encabezaron a los patriotas que «lograron que ese territorio norteño se alzara en insurrección el 29 de diciembre... en el punto conocido como Piedra Bruja. Capturadas por las autoridades españolas, fueron procesadas en Sensuntepeque. Recluidas después en el convento de San Francisco de la localidad de San Vicente de Austria y Lorenzana, las hermanas Miranda fueron condenadas a sufrir [cien] azotes, para ingresar más tarde como siervas sin paga en la casa del párroco doctor Manuel Antonio de Molina y Cañas», relata el investigador salvadoreño.2 María Feliciana de los Ángeles murió en 1812 a los veintidós años de edad, algún tiempo después de haber recibido las descargas del látigo del verdugo frente a la multitud aglomerada en la Plaza Central de San Vicente. De ahí que, además de haber sido declarada Heroína de la Patria en 1976, una alegoría de ella figure en una conocida pintura de los hechos de aquel 5 de noviembre, y que la Asamblea Legislativa salvadoreña en 2003 dispusiera también que su nombre y el de otras mujeres patriotas se inscribieran en el nuevo Monumento a la Libertad, inaugurado el año siguiente en el Museo Militar.3 Gracias a Dios, la historia sagrada nos ha legado asombrosas heroínas cuyo ejemplo han podido seguir mujeres valerosas como María Feliciana y sus compatriotas, a quienes se les rinde tributo en monumentos a la libertad alrededor del mundo. Tal vez la más influyente, llamada Débora, fue no sólo profetiza, poeta y cantautora, sino que llegó a ser también jueza y gran guerrera de Israel.4 De modo que desde tiempos antiguos todos los hombres debiéramos haber sido tan ecuánimes como Dios mismo en cuanto a la importancia del papel que juegan las mujeres en nuestra sociedad. Carlos ReyUn Mensaje a la Concienciawww.conciencia.net 1 «¿Quién fue María Feliciana de los Ángeles Miranda?», El Metropolitano Digital, 25 septiembre 2014 En línea 20 octubre 2021. 2 Carlos Cañas-Dinarte, «Las mujeres de Sensuntepeque», en Historia de mujeres protagonistas de la independencia (1811-1814), pp. 29-31 En línea 20 octubre 2021. 3 Cañas-Dinarte; Wikipedia, s.v. «María Feliciana de los Ángeles Miranda» En línea 20 octubre 2021. 4 Jue 4-5