Podcasts about rfas

In Part 1 of our 2-part "Bruins Mock Offseason" series, we play GM and pick the next head coach of the Boston Bruins as well as decide on contracts for each of the Bruins RFAs and which RFAs we won't be extending an offer to. Plus, we talk about the news of Don Sweeney's contract extension that broke during the recoding. (In Part 2, we will fill in the roster with UFAs and trades and make the Bruins' 7th-overall draft pick.) Follow us on Twitter: @TheSkatePod | @smclaughlin9 | @briandefelice_ | @bridgetteproulx | Email us at skatepod@weei.com Jump to: 00:00 - Marchand & Panthers advance 16:00 - Bruins sign new goalie prospect 17:50 - Mock offseason GMing starts - we choose a head coach for Bruins 23:00 - We decide on contract extensions for the Bruins 5 RFAs 62:00 - Breaking: Sweeney extension info and statements To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

A Mikael Granlund hat trick led the Dallas Stars to a Game 4 win and 3-1 series lead over the President Trophy-winning Winnipeg Jets. We're joined by Ken Wiebe of thew Winnipeg Free Press to discuss what's going wrong for Connor Hellebuyck and company. Plus, we discuss the big pending RFAs now that the official offer sheet compensation tiers are set. 0:00 Welcome to What Chaos!8:05 Stars good or Jets bad?18:40 Ken Wiebe joins33:20 Tocchet to Flyers38:34 RFA compensation DONATE TO THE KOREATOWN COMMUNITY CENTER: https://fundraise.givesmart.com/f/5eru/n?vid=1j9e23 BUY OUR MERCH: https://store.allcitynetwork.com/collections/what-chaos JOIN OUR DISCORD: https://discord.gg/3brHQ2q5V2 Follow us on Twitter:https://twitter.com/WhatChaosShowhttps://twitter.com/DJ_Beanhttps://twitter.com/PeteBlackburnhttps://twitter.com/shawn_depaz VIVID SEATS is offering an exclusive discount on Playoff tickets! Head to https://www.vividseats.com/nhl-playoffs-tickets--sports-nhl-hockey/performer/1144?utm_source=impact&utm_medium=affiliate&utm_campaign=ALLCITY%20NETWORK&utm_promo=2A5Q91Y32KAWS2R or download the Vivid Seats app and use promo code CHAOS30 for $30 off your first ticket purchase of $300 or more. SHADY RAYS: Head to https://shadyrays.com and use code: AC35 for 35% off polarized sunglasses. Try for yourself the shades rated 5 stars by over 300,000 people. FACTOR MEALKITS: Head to https://factormeals.com/whatchaos50  and use code whatchaos50 to get 50% off! PrizePicks - Download the PrizePicks app today and use code WHATCHAOS for to get $50 instantly when you play $5. PrizePicks. Run your game! https://prizepicks.onelink.me/LME0/WHATCHAOS HelloFresh - Get 10 FREE meals at https://hellofresh.com/freechaos. Applied across 7 boxes, new subscribers only, varies by plan. Hall of Fame App: Get a 7-Day Free Trial + 50% Off your first month with code CHAOS. Just download the HOF app on iOS and Android or visit hofbets.com, enter code CHAOS, and you're all set.

On hour one of Flames Talk, Pat Steinberg and Wes Gilbertson break down what's next on Craig Conroy's offseason checklist. After sorting out the RFAs. with long-term talks likely for Kevin Bahl and a bridge deal making sense for Connor Zary, the focus shifts to the Flames' UFAs like Dan Vladar, Joel Hanley, and Anthony Mantha, as well as some of the members of the Calgary Wranglers.(43:49) The guys continue their dive on Justin Kirkland, Devin Cooley, and more!The views and opinions expressed in this podcast are those of the hosts and guests and do not necessarily reflect the position of Rogers Media Inc. or any affiliate. https://www.sportsnet.ca/960/flames-talk/

Katie, Nick and Dan return to talk the Flyers firing Rocky Thompson, the goalie disaster, Couts is a bad captain, do you trust Briere? potential RFAs, more!

On the latest episode of the Blackhawks Breakaway Podcast, Pat Boyle and Charlie Roumeliotis break down which pending unrestricted and restricted free agents the Blackhawks should consider bringing back for the 2025-26 season. They discuss what Ryan Donato's next contract might look like and what could be holding it up. The guys also react to the first round of the Stanley Cup Playoffs, including former Blackhawks forward Colin Blackwell's overtime winner in Game 2 for Dallas, the battle of Ontario, and more.

The CHGO Bulls crew get into the numbers of Coby White and Josh Giddey before and after the All Star break. Is what we've seen post all star break enough to conclude they are the backcourt of the future? Plus, with Giddey's contract due to be renewed, we look at what other RFAs are in position to receive this offseason. Also will Giddey's contract have any bearing on what Coby White will get on his next deal?

“Eventually, my dream would be to simulate a virtual cell.”—Demis HassabisThe aspiration to build the virtual cell is considered to be equivalent to a moonshot for digital biology. Recently, 42 leading life scientists published a paper in Cell on why this is so vital, and how it may ultimately be accomplished. This conversation is with 2 of the authors, Charlotte Bunne, now at EPFL and Steve Quake, a Professor at Stanford University, who heads up science at the Chan-Zuckerberg Initiative The audio (above) is available on iTunes and Spotify. The full video is linked here, at the top, and also can be found on YouTube.TRANSCRIPT WITH LINKS TO AUDIO Eric Topol (00:06):Hello, it's Eric Topol with Ground Truths and we've got a really hot topic today, the virtual cell. And what I think is extraordinarily important futuristic paper that recently appeared in the journal Cell and the first author, Charlotte Bunne from EPFL, previously at Stanford's Computer Science. And Steve Quake, a young friend of mine for many years who heads up the Chan Zuckerberg Initiative (CZI) as well as a professor at Stanford. So welcome, Charlotte and Steve.Steve Quake (00:42):Thanks, Eric. It's great to be here.Charlotte Bunne:Thanks for having me.Eric Topol (00:45):Yeah. So you wrote this article that Charlotte, the first author, and Steve, one of the senior authors, appeared in Cell in December and it just grabbed me, “How to build the virtual cell with artificial intelligence: Priorities and opportunities.” It's the holy grail of biology. We're in this era of digital biology and as you point out in the paper, it's a convergence of what's happening in AI, which is just moving at a velocity that's just so extraordinary and what's happening in biology. So maybe we can start off by, you had some 42 authors that I assume they congregated for a conference or something or how did you get 42 people to agree to the words in this paper?Steve Quake (01:33):We did. We had a meeting at CZI to bring community members together from many different parts of the community, from computer science to bioinformatics, AI experts, biologists who don't trust any of this. We wanted to have some real contrarians in the mix as well and have them have a conversation together about is there an opportunity here? What's the shape of it? What's realistic to expect? And that was sort of the genesis of the article.Eric Topol (02:02):And Charlotte, how did you get to be drafting the paper?Charlotte Bunne (02:09):So I did my postdoc with Aviv Regev at Genentech and Jure Leskovec at CZI and Jure was part of the residency program of CZI. And so, this is how we got involved and you had also prior work with Steve on the universal cell embedding. So this is how everything got started.Eric Topol (02:29):And it's actually amazing because it's a who's who of people who work in life science, AI and digital biology and omics. I mean it's pretty darn impressive. So I thought I'd start off with a quote in the article because it kind of tells a story of where this could go. So the quote was in the paper, “AIVC (artificial intelligence virtual cell) has the potential to revolutionize the scientific process, leading to future breakthroughs in biomedical research, personalized medicine, drug discovery, cell engineering, and programmable biology.” That's a pretty big statement. So maybe we can just kind of toss that around a bit and maybe give it a little more thoughts and color as to what you were positing there.Steve Quake (03:19):Yeah, Charlotte, you want me to take the first shot at that? Okay. So Eric, it is a bold claim and we have a really bold ambition here. We view that over the course of a decade, AI is going to provide the ability to make a transformative computational tool for biology. Right now, cell biology is 90% experimental and 10% computational, roughly speaking. And you've got to do just all kinds of tedious, expensive, challenging lab work to get to the answer. And I don't think AI is going to replace that, but it can invert the ratio. So within 10 years I think we can get to biology being 90% computational and 10% experimental. And the goal of the virtual cell is to build a tool that'll do that.Eric Topol (04:09):And I think a lot of people may not understand why it is considered the holy grail because it is the fundamental unit of life and it's incredibly complex. It's not just all the things happening in the cell with atoms and molecules and organelles and everything inside, but then there's also the interactions the cell to other cells in the outside tissue and world. So I mean it's really quite extraordinary challenge that you've taken on here. And I guess there's some debate, do we have the right foundation? We're going to get into foundation models in a second. A good friend of mine and part of this whole I think process that you got together, Eran Segal from Israel, he said, “We're at this tipping point…All the stars are aligned, and we have all the different components: the data, the compute, the modeling.” And in the paper you describe how we have over the last couple of decades have so many different data sets that are rich that are global initiatives. But then there's also questions. Do we really have the data? I think Bo Wang especially asked about that. Maybe Charlotte, what are your thoughts about data deficiency? There's a lot of data, but do you really have what we need before we bring them all together for this kind of single model that will get us some to the virtual cell?Charlotte Bunne (05:41):So I think, I mean one core idea of building this AIVC is that we basically can leverage all experimental data that is overall collected. So this also goes back to the point Steve just made. So meaning that we basically can integrate across many different studies data because we have AI algorithms or the architectures that power such an AIVC are able to integrate basically data sets on many different scales. So we are going a bit away from this dogma. I'm designing one algorithm from one dataset to this idea of I have an architecture that can take in multiple dataset on multiple scales. So this will help us a bit in being somewhat efficient with the type of experiments that we need to make and the type of experiments we need to conduct. And again, what Steve just said, ultimately, we can very much steer which data sets we need to collect.Charlotte Bunne (06:34):Currently, of course we don't have all the data that is sufficient. I mean in particular, I think most of the tissues we have, they are healthy tissues. We don't have all the disease phenotypes that we would like to measure, having patient data is always a very tricky case. We have mostly non-interventional data, meaning we have very limited understanding of somehow the effect of different perturbations. Perturbations that happen on many different scales in many different environments. So we need to collect a lot here. I think the overall journey that we are going with is that we take the data that we have, we make clever decisions on the data that we will collect in the future, and we have this also self-improving entity that is aware of what it doesn't know. So we need to be able to understand how well can I predict something on this somewhat regime. If I cannot, then we should focus our data collection effort into this. So I think that's not a present state, but this will basically also guide the future collection.Eric Topol (07:41):Speaking of data, one of the things I think that's fascinating is we saw how AlphaFold2 really revolutionized predicting proteins. But remember that was based on this extraordinary resource that had been built, the Protein Data Bank that enabled that. And for the virtual cell there's no such thing as a protein data bank. It's so much more as you emphasize Charlotte, it's so much dynamic and these perturbations that are just all across the board as you emphasize. Now the human cell atlas, which currently some tens of millions, but going into a billion cells, we learned that it used to be 200 cell types. Now I guess it's well over 5,000 and that we have 37 trillion cells approximately in the average person adult's body is a formidable map that's being made now. And I guess the idea that you're advancing is that we used to, and this goes back to a statement you made earlier, Steve, everything we did in science was hypothesis driven. But if we could get computational model of the virtual cell, then we can have AI exploration of the whole field. Is that really the nuts of this?Steve Quake (09:06):Yes. A couple thoughts on that, maybe Theo Karaletsos, our lead AI person at CZI says machine learning is the formalism through which we understand high dimensional data and I think that's a very deep statement. And biological systems are intrinsically very high dimensional. You've got 20,000 genes in the human genome in these cell atlases. You're measuring all of them at the same time in each single cell. And there's a lot of structure in the relationships of their gene expression there that is just not evident to the human eye. And for example, CELL by GENE, our database that collects all the aggregates, all of the single cell transcriptomic data is now over a hundred million cells. And as you mentioned, we're seeing ways to increase that by an order of magnitude in the near future. The project that Jure Leskovec and I worked on together that Charlotte referenced earlier was like a first attempt to build a foundational model on that data to discover some of the correlations and structure that was there.Steve Quake (10:14):And so, with a subset, I think it was the 20 or 30 million cells, we built a large language model and began asking it, what do you understand about the structure of this data? And it kind of discovered lineage relationships without us teaching it. We trained on a matrix of numbers, no biological information there, and it learned a lot about the relationships between cell type and lineage. And that emerged from that high dimensional structure, which was super pleasing to us and really, I mean for me personally gave me the confidence to say this stuff is going to work out. There is a future for the virtual cell. It's not some made up thing. There is real substance there and this is worth investing an enormous amount of CZIs resources in going forward and trying to rally the community around as a project.Eric Topol (11:04):Well yeah, the premise here is that there is a language of life, and you just made a good case that there is if you can predict, if you can query, if you can generate like that. It is reminiscent of the famous Go game of Lee Sedol, that world champion and how the machine came up with a move (Move 37) many, many years ago that no human would've anticipated and I think that's what you're getting at. And the ability for inference and reason now to add to this. So Charlotte, one of the things of course is about, well there's two terms in here that are unfamiliar to many of the listeners or viewers of this podcast, universal representations (UR) and virtual instrument (VIs) that you make a pretty significant part of how you are going about this virtual cell model. So could you describe that and also the embeddings as part of the universal representation (UR) because I think embeddings, or these meaningful relationships are key to what Steve was just talking about.Charlotte Bunne (12:25):Yes. So in order to somewhat leverage very different modalities in order to leverage basically modalities that will take measurements across different scales, like the idea is that we have large, may it be transformer models that might be very different. If I have imaging data, I have a vision transformer, if I have a text data, I have large language models that are designed of course for DNA then they have a very wide context and so on and so forth. But the idea is somewhat that we have models that are connected through the scales of biology because those scales we know. We know which components are somewhat involved or in measurements that are happening upstream. So we have the somewhat interconnection or very large model that will be trained on many different data and we have this internal model representation that somewhat capture everything they've seen. And so, this is what we call those universal representation (UR) that will exist across the scales of biology.Charlotte Bunne (13:22):And what is great about AI, and so I think this is a bit like a history of AI in short is the ability to predict the last years, the ability to generate, we can generate new hypothesis, we can generate modalities that we are missing. We can potentially generate certain cellular state, molecular state have a certain property, but I think what's really coming is this ability to reason. So we see this in those very large language models, the ability to reason about a hypothesis, how we can test it. So this is what those instruments ultimately need to do. So we need to be able to simulate the change of a perturbation on a cellular phenotype. So on the internal representation, the universal representation of a cell state, we need to simulate the fact the mutation has downstream and how this would propagate in our representations upstream. And we need to build many different type of virtual instruments that allow us to basically design and build all those capabilities that ultimately the AI virtual cell needs to possess that will then allow us to reason, to generate hypothesis, to basically predict the next experiment to conduct to predict the outcome of a perturbation experiment to in silico design, cellular states, molecular states, things like that. And this is why we make the separation between internal representation as well as those instruments that operate on those representations.Eric Topol (14:47):Yeah, that's what I really liked is that you basically described the architecture, how you're going to do this. By putting these URs into the VIs, having a decoder and a manipulator and you basically got the idea if you can bring all these different integrations about which of course is pending. Now there are obviously many naysayers here that this is impossible. One of them is this guy, Philip Ball. I don't know if you read the language, How Life Works. Now he's a science journalist and he's a prolific writer. He says, “Comparing life to a machine, a robot, a computer, sells it short. Life is a cascade of processes, each with a distinct integrity and autonomy, the logic of which has no parallel outside the living world.” Is he right? There's no way to model this. It's silly, it's too complex.Steve Quake (15:50):We don't know, alright. And it's great that there's naysayers. If everyone agreed this was doable, would it be worth doing? I mean the whole point is to take risks and get out and do something really challenging in the frontier where you don't know the answer. If we knew that it was doable, I wouldn't be interested in doing it. So I personally am happy that there's not a consensus.Eric Topol (16:16):Well, I mean to capture people's imagination here, if you're successful and you marshal a global effort, I don't know who's going to pay for it because it's a lot of work coming here going forward. But if you can do it, the question here is right today we talk about, oh let's make an organoid so we can figure out how to treat this person's cancer or understand this person's rare disease or whatever. And instead of having to wait weeks for this culture and all the expense and whatnot, you could just do it in a computer and in silico and you have this virtual twin of a person's cells and their tissue and whatnot. So the opportunity here is, I don't know if people get, this is just extraordinary and quick and cheap if you can get there. And it's such a bold initiative idea, who will pay for this do you think?Steve Quake (17:08):Well, CZI is putting an enormous amount of resources into it and it's a major project for us. We have been laying the groundwork for it. We recently put together what I think is if not the largest, one of the largest GPU supercomputer clusters for nonprofit basic science research that came online at the end of last year. And in fact in December we put out an RFA for the scientific community to propose using it to build models. And so we're sharing that resource within the scientific community as I think you appreciate, one of the real challenges in the field has been access to compute resources and industry has it academia at a much lower level. We are able to be somewhere in between, not quite at the level of a private company but the tech company but at a level beyond what most universities are being able to do and we're trying to use that to drive the field forward. We're also planning on launching RFAs we this year to help drive this project forward and funding people globally on that. And we are building a substantial internal effort within CZI to help drive this project forward.Eric Topol (18:17):I think it has the looks of the human genome project, which at time as you know when it was originally launched that people thought, oh, this is impossible. And then look what happened. It got done. And now the sequence of genome is just a commodity, very relatively, very inexpensive compared to what it used to be.Steve Quake (18:36):I think a lot about those parallels. And I will say one thing, Philip Ball, I will concede him the point, the cells are very complicated. The genome project, I mean the sort of genius there was to turn it from a biology problem to a chemistry problem, there is a test tube with a chemical and it work out the structure of that chemical. And if you can do that, the problem is solved. I think what it means to have the virtual cell is much more complex and ambiguous in terms of defining what it's going to do and when you're done. And so, we have our work cut out for us there to try to do that. And that's why a little bit, I established our North Star and CZI for the next decade as understanding the mysteries of the cell and that word mystery is very important to me. I think the molecules, as you pointed out earlier are understood, genome sequenced, protein structure solved or predicted, we know a lot about the molecules. Those are if not solved problems, pretty close to being solved. And the real mystery is how do they work together to create life in the cell? And that's what we're trying to answer with this virtual cell project.Eric Topol (19:43):Yeah, I think another thing that of course is happening concurrently to add the likelihood that you'll be successful is we've never seen the foundation models coming out in life science as they have in recent weeks and months. Never. I mean, I have a paper in Science tomorrow coming out summarizing the progress about not just RNA, DNA, ligands. I mean the whole idea, AlphaFold3, but now Boltz and so many others. It's just amazing how fast the torrent of new foundation models. So Charlotte, what do you think accounts for this? This is unprecedented in life science to see foundation models coming out at this clip on evolution on, I mean you name it, design of every different molecule of life or of course in cells included in that. What do you think is going on here?Charlotte Bunne (20:47):So on the one hand, of course we benefit profits and inherit from all the tremendous efforts that have been made in the last decades on assembling those data sets that are very, very standardized. CELLxGENE is very somehow AI friendly, as you can say, it is somewhat a platform that is easy to feed into algorithms, but at the same time we actually also see really new building mechanisms, design principles of AI algorithms in itself. So I think we have understood that in order to really make progress, build those systems that work well, we need to build AI tools that are designed for biological data. So to give you an easy example, if I use a large language model on text, it's not going to work out of the box for DNA because we have different reading directions, different context lens and many, many, many, many more.Charlotte Bunne (21:40):And if I look at standard computer vision where we can say AI really excels and I'm applying standard computer vision, vision transformers on multiplex images, they're not going to work because normal computer vision architectures, they always expect the same three inputs, RGB, right? In multiplex images, I'm measuring up to 150 proteins potentially in a single experiment, but every study will measure different proteins. So I deal with many different scales like larger scales and I used to attention mechanisms that we have in usual computer vision. Transformers are not going to work anymore, they're not going to scale. And at the same time, I need to be completely flexible in whatever input combination of channel I'm just going to face in this experiment. So this is what we right now did for example, in our very first work, inheriting the design principle that we laid out in the paper AI virtual cell and then come up with new AI architectures that are dealing with these very special requirements that biological data have.Charlotte Bunne (22:46):So we have now a lot of computer scientists that work very, very closely have a very good understanding of biologists. Biologists that are getting much and much more into the computer science. So people who are fluent in both languages somewhat, that are able to now build models that are adopted and designed for biological data. And we don't just take basically computer vision architectures that work well on street scenes and try to apply them on biological data. So it's just a very different way of thinking about it, starting constructing basically specialized architectures, besides of course the tremendous data efforts that have happened in the past.Eric Topol (23:24):Yeah, and we're not even talking about just sequence because we've also got imaging which has gone through a revolution, be able to image subcellular without having to use any types of stains that would disrupt cells. That's another part of the deep learning era that came along. One thing I thought was fascinating in the paper in Cell you wrote, “For instance, the Short Read Archive of biological sequence data holds over 14 petabytes of information, which is 1,000 times larger than the dataset used to train ChatGPT.” I mean that's a lot of tokens, that's a lot of stuff, compute resources. It's almost like you're going to need a DeepSeek type of way to get this. I mean not that DeepSeek as its claim to be so much more economical, but there's a data challenge here in terms of working with that massive amount that is different than the human language. That is our language, wouldn't you say?Steve Quake (24:35):So Eric, that brings to mind one of my favorite quotes from Sydney Brenner who is such a wit. And in 2000 at the sort of early first flush of success in genomics, he said, biology is drowning in a sea of data and starving for knowledge. A very deep statement, right? And that's a little bit what the motivation was for putting the Short Read Archive statistic into the paper there. And again, for me, part of the value of this endeavor of creating a virtual cell is it's a tool to help us translate data into knowledge.Eric Topol (25:14):Yeah, well there's two, I think phenomenal figures in your Cell paper. The first one that kicks across the capabilities of the virtual cell and the second that compares the virtual cell to the real or the physical cell. And we'll link that with this in the transcript. And the other thing we'll link is there's a nice Atlantic article, “A Virtual Cell Is a ‘Holy Grail' of Science. It's Getting Closer.” That might not be quite close as next week or year, but it's getting close and that's good for people who are not well grounded in this because it's much more taken out of the technical realm. This is really exciting. I mean what you're onto here and what's interesting, Steve, since I've known you for so many years earlier in your career you really worked on omics that is being DNA and RNA and in recent times you've made this switch to cells. Is that just because you're trying to anticipate the field or tell us a little bit about your migration.Steve Quake (26:23):Yeah, so a big part of my career has been trying to develop new measurement technologies that'll provide insight into biology. And decades ago that was understanding molecules. Now it's understanding more complex biological things like cells and it was like a natural progression. I mean we built the sequencers, sequenced the genomes, done. And it was clear that people were just going to do that at scale then and create lots of data. Hopefully knowledge would get out of that. But for me as an academic, I never thought I'd be in the position I'm in now was put it that way. I just wanted to keep running a small research group. So I realized I would have to get out of the genome thing and find the next frontier and it became this intersection of microfluidics and genomics, which as you know, I spent a lot of time developing microfluidic tools to analyze cells and try to do single cell biology to understand their heterogeneity. And that through a winding path led me to all these cell atlases and to where we are now.Eric Topol (27:26):Well, we're fortunate for that and also with your work with CZI to help propel that forward and I think it sounds like we're going to need a lot of help to get this thing done. Now Charlotte, as a computer scientist now at EPFL, what are you going to do to keep working on this and what's your career advice for people in computer science who have an interest in digital biology?Charlotte Bunne (27:51):So I work in particular on the prospect of using this to build diagnostic tools and to make diagnostics in the clinic easier because ultimately we have somewhat limited capabilities in the hospital to run deep omics, but the idea of being able to somewhat map with a cheaper and lighter modality or somewhat diagnostic test into something much richer because a model has been seeing all those different data and can basically contextualize it. It's very interesting. We've seen all those pathology foundation models. If I can always run an H&E, but then decide when to run deeper diagnostics to have a better or more accurate prediction, that is very powerful and it's ultimately reducing the costs, but the precision that we have in hospitals. So my faculty position right now is co-located between the School of Life Sciences, School of Computer Science. So I have a dual affiliation and I'm affiliated to the hospitals to actually make this possible and as a career advice, I think don't be shy and stick to your discipline.Charlotte Bunne (28:56):I have a bachelor's in biology, but I never only did biology. I have a PhD in computer science, which you would think a bachelor in biology not necessarily qualifies you through. So I think this interdisciplinarity also requires you to be very fluent, very comfortable in reading many different styles of papers and publications because a publication in a computer science venue will be very, very different from the way we write in biology. So don't stick to your study program, but just be free in selecting whatever course gets you closer to the knowledge you need in order to do the research or whatever task you are building and working on.Eric Topol (29:39):Well, Charlotte, the way you're set up there with this coalescence of life science and computer science is so ideal and so unusual here in the US, so that's fantastic. That's what we need and that's really the underpinning of how you're going to get to the virtual cells, getting these two communities together. And Steve, likewise, you were an engineer and somehow you became one of the pioneers of digital biology way back before it had that term, this interdisciplinary, transdisciplinary. We need so much of that in order for you all to be successful, right?Steve Quake (30:20):Absolutely. I mean there's so much great discovery to be done on the boundary between fields. I trained as a physicist and kind of made my career this boundary between physics and biology and technology development and it's just sort of been a gift that keeps on giving. You've got a new way to measure something, you discover something new scientifically and it just all suggests new things to measure. It's very self-reinforcing.Eric Topol (30:50):Now, a couple of people who you know well have made some pretty big statements about this whole era of digital biology and I think the virtual cell is perhaps the biggest initiative of all the digital biology ongoing efforts, but Jensen Huang wrote, “for the first time in human history, biology has the opportunity to be engineering, not science.” And Demis Hassabis wrote or said, ‘we're seeing engineering science, you have to build the artifact of interest first, and then once you have it, you can use the scientific method to reduce it down and understand its components.' Well here there's a lot to do to understand its components and if we can do that, for example, right now as both of AI drug discoveries and high gear and there's umpteen numbers of companies working on it, but it doesn't account for the cell. I mean it basically is protein, protein ligand interactions. What if we had drug discovery that was cell based? Could you comment about that? Because that doesn't even exist right now.Steve Quake (32:02):Yeah, I mean I can say something first, Charlotte, if you've got thoughts, I'm curious to hear them. So I do think AI approaches are going to be very useful designing molecules. And so, from the perspective of designing new therapeutics, whether they're small molecules or antibodies, yeah, I mean there's a ton of investment in that area that is a near term fruit, perfect thing for venture people to invest in and there's opportunity there. There's been enough proof of principle. However, I do agree with you that if you want to really understand what happens when you drug a target, you're going to want to have some model of the cell and maybe not just the cell, but all the different cell types of the body to understand where toxicity will come from if you have on-target toxicity and whether you get efficacy on the thing you're trying to do.Steve Quake (32:55):And so, we really hope that people will use the virtual cell models we're going to build as part of the drug discovery development process, I agree with you in a little of a blind spot and we think if we make something useful, people will be using it. The other thing I'll say on that point is I'm very enthusiastic about the future of cellular therapies and one of our big bets at CZI has been starting the New York Biohub, which is aimed at really being very ambitious about establishing the engineering and scientific foundations of how to engineer completely, radically more powerful cellular therapies. And the virtual cell is going to help them do that, right? It's going to be essential for them to achieve that mission.Eric Topol (33:39):I think you're pointing out one of the most important things going on in medicine today is how we didn't anticipate that live cell therapy, engineered cells and ideally off the shelf or in vivo, not just having to take them out and work on them outside the body, is a revolution ongoing, and it's not just in cancer, it's in autoimmune diseases and many others. So it's part of the virtual cell need. We need this. One of the things that's a misnomer, I want you both to comment on, we keep talking about single cell, single cell. And there's a paper spatial multi-omics this week, five different single cell scales all integrated. It's great, but we don't get to single cell. We're basically looking at 50 cells, 100 cells. We're not doing single cell because we're not going deep enough. Is that just a matter of time when we actually are doing, and of course the more we do get down to the single or a few cells, the more insights we're going to get. Would you comment about that? Because we have all this literature on single cell comes out every day, but we're not really there yet.Steve Quake (34:53):Charlotte, do you want to take a first pass at that and then I can say something?Charlotte Bunne (34:56):Yes. So it depends. So I think if we look at certain spatial proteomics, we still have subcellular resolutions. So of course, we always measure many different cells, but we are able to somewhat get down to resolution where we can look at certain colocalization of proteins. This also goes back to the point just made before having this very good environment to study drugs. If I want to build a new drug, if I want to build a new protein, the idea of building this multiscale model allows us to actually simulate different, somehow binding changes and binding because we simulate the effect of a drug. Ultimately, the redouts we have they are subcellular. So of course, we often in the spatial biology, we often have a bit like methods that are rather coarse they have a spot that averages over certain some cells like hundreds of cells or few cells.Charlotte Bunne (35:50):But I think we also have more and more technologies that are zooming in that are subcellular where we can actually tag or have those probe-based methods that allow us to zoom in. There's microscopy of individual cells to really capture them in 3D. They are of course not very high throughput yet, but it gives us also an idea of the morphology and how ultimately morphology determine certain somehow cellular properties or cellular phenotype. So I think there's lots of progress also on the experimental and that ultimately will back feed into the AI virtual cell, those models that will be fed by those data. Similarly, looking at dynamics, right, looking at live imaging of individual cells of their morphological changes. Also, this ultimately is data that we'll need to get a better understanding of disease mechanisms, cellular phenotypes functions, perturbation responses.Eric Topol (36:47):Right. Yes, Steve, you can comment on that and the amazing progress that we have made with space and time, spatial temporal resolution, spatial omics over these years, but that we still could go deeper in terms of getting to individual cells, right?Steve Quake (37:06):So, what can we do with a single cell? I'd say we are very mature in our ability to amplify and sequence the genome of a single cell, amplify and sequence the transcriptome of a single cell. You can ask is one cell enough to make a biological conclusion? And maybe I think what you're referring to is people want to see replicates and so you can ask how many cells do you need to see to have confidence in any given biological conclusion, which is a reasonable thing. It's a statistical question in good science. I think I've been very impressed with how the mass spec people have been doing recently. I think they've finally cracked the ability to look at proteins from single cells and they can look at a couple thousand proteins. That was I think one of these Nature method of the year things at the end of last year and deep visual proteomics.Eric Topol (37:59):Deep visual proteomics, yes.Steve Quake (38:00):Yeah, they are over the hump. Yeah, they are over the hump with single cell measurements. Part of what's missing right now I think is the ability to reliably do all of that on the same cell. So this is what Charlotte was referring to be able to do sort of multi-modal measurements on single cells. That's kind of in its infancy and there's a few examples, but there's a lot more work to be done on that. And I think also the fact that these measurements are all destructive right now, and so you're losing the ability to look how the cells evolve over time. You've got to say this time point, I'm going to dissect this thing and look at a state and I don't get to see what happens further down the road. So that's another future I think measurement challenge to be addressed.Eric Topol (38:42):And I think I'm just trying to identify some of the multitude of challenges in this extraordinarily bold initiative because there are no shortage and that's good about it. It is given people lots of work to do to overcome, override some of these challenges. Now before we wrap up, besides the fact that you point out that all the work has to be done and be validated in real experiments, not just live in a virtual AI world, but you also comment about the safety and ethics of this work and assuming you're going to gradually get there and be successful. So could either or both of you comment about that because it's very thoughtful that you're thinking already about that.Steve Quake (41:10):As scientists and members of the larger community, we want to be careful and ensure that we're interacting with people who said policy in a way that ensures that these tools are being used to advance the cause of science and not do things that are detrimental to human health and are used in a way that respects patient privacy. And so, the ethics around how you use all this with respect to individuals is going to be important to be thoughtful about from the beginning. And I also think there's an ethical question around what it means to be publishing papers and you don't want people to be forging papers using data from the virtual cell without being clear about where that came from and pretending that it was a real experiment. So there's issues around those sorts of ethics as well that need to be considered.Eric Topol (42:07):And of those 40 some authors, do you around the world, do you have the sense that you all work together to achieve this goal? Is there kind of a global bonding here that's going to collaborate?Steve Quake (42:23):I think this effort is going to go way beyond those 40 authors. It's going to include a much larger set of people and I'm really excited to see that evolve with time.Eric Topol (42:31):Yeah, no, it's really quite extraordinary how you kick this thing off and the paper is the blueprint for something that we are all going to anticipate that could change a lot of science and medicine. I mean we saw, as you mentioned, Steve, how that deep visual proteomics (DVP) saved lives. It was what I wrote a spatial medicine, no longer spatial biology. And so, the way that this can change the future of medicine, I think a lot of people just have to have a little bit of imagination that once we get there with this AIVC, that there's a lot in store that's really quite exciting. Well, I think this has been an invigorating review of that paper and some of the issues surrounding it. I couldn't be more enthusiastic for your success and ultimately where this could take us. Did I miss anything during the discussion that we should touch on before we wrap up?Steve Quake (43:31):Not from my perspective. It was a pleasure as always Eric, and a fun discussion.Charlotte Bunne (43:38):Thanks so much.Eric Topol (43:39):Well thank you both and all the co-authors of this paper. We're going to be following this with the great interest, and I think for most people listening, they may not know that this is in store for the future. Someday we will get there. I think one of the things to point out right now is the models we have today that large language models based on transformer architecture, they're going to continue to evolve. We're already seeing so much in inference and ability for reasoning to be exploited and not asking for prompts with immediate answers, but waiting for days to get back. A lot more work from a lot more computing resources. But we're going to get models in the future to fold this together. I think that's one of the things that you've touched on the paper so that whatever we have today in concert with what you've laid out, AI is just going to keep getting better.Eric Topol (44:39):The biology that these foundation models are going to get broader and more compelling as to their use cases. So that's why I believe in this. I don't see this as a static situation right now. I just think that you're anticipating the future, and we will have better models to be able to integrate this massive amount of what some people would consider disparate data sources. So thank you both and all your colleagues for writing this paper. I don't know how you got the 42 authors to agree to it all, which is great, and it's just a beginning of something that's a new frontier. So thanks very much.Steve Quake (45:19):Thank you, Eric.**********************************************Thanks for listening, watching or reading Ground Truths. Your subscription is greatly appreciated.If you found this podcast interesting please share it!That makes the work involved in putting these together especially worthwhile.All content on Ground Truths—newsletters, analyses, and podcasts—is free, open-access, with no ads..Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. And such support is becoming more vital In light of current changes of funding by US biomedical research at NIH and other governmental agencies.Thanks to my producer Jessica Nguyen and to Sinjun Balabanoff for audio and video support at Scripps Research. Get full access to Ground Truths at erictopol.substack.com/subscribe

Isaiah, Chef and Dan are back with special guest Kevin Durso, from 973espn.com. We begin the night discussing the Flyers recent post-4 nations tournament surge, going 4-0-1 over their last five games. Then we dive into the impending trade deadline and which Flyers could be on the move before March 7, along with some background behind the so-called “Laughts Supper”.  We close out the show discussing Matvei Michkov's rookie of the month award; the improvement of Jamie Drysdale; the mystery behind Aleksei Kolosov's usage; our speculation on the Flyers upcoming RFAs; Danny Briere's off-season planning and more!    

There was a bit in an old radio show (Kevin-and-Bean KROQ old, not Little Orphan Annie old) had Ralph Garman review movies he'd never seen, based only on watching the trailers. In this episode, we review some cases we haven't read. We discuss the cases below, which lead to some good tangents.When discovery objections have been waived, does serving responses that still contain the waived objections count as “substantial compliance”? Trial court said no, but the correct answer is Yes, says Katayama v. Cont'l Inv. Grp. (D4d3 Oct. 9, 2024 No. G063872) [published].Discussing the difference between waiver and forfeiture. N. Am. Title Co. v. The Superior Court. (Cal. Oct. 28, 2024 No. S280752).Satisfying judgment renders appeal moot: In Baker Entm't, LLC v. Emmett Furla Oasis Films, LLC . (2D7d Oct. 28, 2024. No. B323388) (nonpub. opn.)Failing to respond to demand for punitive damages information, defendant forfeited its challenge to $15M punitives award. (Mosley v. Pacifica Bakersfield, L.P. (D5 Sep. 19, 2024 No. F084699) (nonpub. opn.).To Avoid Unjust Result, Unambiguous Statute Held Ambiguous.  In re Marriage of Cady and Gamick (D2d1 Sep. 25, 2024 No. B326716)Other items discussed in the episode:Headnotes 11/21/24: Judge Bias Can Be Forfeited But Not Defective ServiceLate objections to RFAs do not invalidate otherwise substantive responsesHeadnotes: one-sentence summaries of this week's below-the-fold cases

Ryan Gilbert and Joe DeMarini discuss the Philadelphia Flyers' decision to send down Emil Andrae, the back-and-forth third period against the Blue Jackets, how the Owen Tippett and Travis Konecny contracts are looking, which pending RFAs the Flyers should lock up, and more!

NHL writer for Sportsnet, Luke Fox, joins JD at the top of the show to talk about the amount of RFAs in the NHL, deal trends, Evan Bouchard, Matthew Knies, Leafs duos, and how Toronto will split the net (00:00). Then, ESPN MLB insider and prospect specialist, Kiley McDaniel, talks with JD about the Blue Jays' farm system, Jake Bloss, Toronto's offseason, and the MLB reliever market (32:00). After, NFL writer for Yahoo, Charles McDonald, joins the program to speak about the fallout for the Bengals after their 35-34 loss to the Ravens, Joe Burrow, Zac Taylor, Baltimore's struggling defence, Roquan Smith, which NFC team could challenge the Lions, and if the Jets can upset the Cardinals in Week 10 (53:00). The show ends with 'What We Missed!' (1:21:30).The views and opinions expressed in this podcast are those of the hosts and guests and do not necessarily reflect the position of Rogers Sports & Media or any affiliates. 

Haize, Stevo & Big Kev discuss Moses Moody getting his extension & other pending RFAs who didn't get their deals. The guys also discuss Khris Middleton missing the start of the season and Kevin Durant's future.Podcast Links: https://linktr.ee/nbacentralGet at us:Email: NBACentralShow@gmail.comTwitter: @CEOHaizePhone: ‪(773) 270-2799‬

On This episode of The Chris Johnston show Julian McKenzie and Chris Johnston go over a variety of topics including: 0:00 Max Pacioretty signs with Maple Leafs 2:30 Nick Robertson extension 6:00 Any Leafs moves left? 8:30 UFAs & PTOs 11:50 James Van Riemsdyk 14:30 The RFAs left to sign 18:00 When Sidney Crosby going to sign? 28:35 Your questions on Ask CJ Follow us on Twitter: @sdpnsports Follow us on Instagram: @sdpnsports Reach out to https://www.sdpn.ca/sales to connect with our sales team and discuss the opportunity to integrate your brand within our content! Learn more about your ad choices. Visit megaphone.fm/adchoices

The Detroit Red Wings are not far away from hitting the ice for training camp in Traverse City, and Moritz Seider, Lucas Raymond, and Jonatan Berggren are still unsigned. Tune in as we start by discussing updates (or lack thereof) on Hockeytown's unsigned RFAs, whether there's anything to be concerned about with Raymond or Seider, how this compares to the Larkin or DeBrincat situations, Steve Yzerman's negotiation tactics across the board (3:55), where Berggren's contract fits in, and  lots more (22:50). After that, Leon Draisaitl's eye-watering $14 million dollar AAV contract, how this impacts McDavid & Bouchard, & stacks up to Matthews, MacKinnon, & other superstars, & whether Edmonton is headed for a Leafs-like situation (with Marner potentially on the outs) (26:55). Also, updates on Zadina & Kubalik, thoughts on Crosby's final phase, Ducks and Utah jerseys, & lots more (46:50) before we take your questions & comments in our Overtime segment (57:35) - enjoy the show! Head over to wingedwheelpodcast.com to find all the ways to listen, how to support the show, and so much more! HelloFresh: America's # Meal Kit. For FREE breakfast for life, go to HelloFresh.com/FreeWingedWheel. (One free breakfast item per box while subscription is active). #ad

Boys chat about Uncle Leon Ticket, unsigned RFAs...does Swayman become top paid goalie?! And Thornton and Marleau grooming the kids!

During Hour 4 Max Bultman from The Athletic covering the Detroit Red Wings joined the show discussing the Wings' offseason, RFAs, goaltending, and more. Hosted on Acast. See acast.com/privacy for more information.

The beauty of a daily show is what we don't get to one day, we always have tomorrow!Ryan Johansen, Kurt Overhardt, the NHL CBA and all that fun stuff took over “What if?” Wednesday, so we're tackling some hypotheticals today!What if Nolan Patrick was 4 days younger, making him draft eligible in 2016? What if the Flyers go after Peyton Krebs or one of the 20-or-so unsigned RFAs?Charlie & Bill get into these and more, plus a look at the NHL's top-20 centers.

In this exciting video, we take on the ultimate challenge of Building the BEST NHL Team from Each Region in 2024! Join us as we dive into the rich history and talent pool of hockey across North America, analyzing the top players from key regions. From the heart of Canada (Alberta, Ontario, Quebec, Saskatchewan) to the vibrant United States (Michigan, New York, Minnesota, and Massachusetts), we'll explore the unique strengths and styles that each region brings to the ice. Watch as we break down player stats, regional strengths, and fan favorites to assemble a powerhouse team that showcases the best talent from across the NHL landscape. Whether you're a die-hard hockey fan or new to the sport, this video is packed with insights, analysis, and plenty of hockey action!Don't forget to like, comment, and subscribe for more NHL content and let us know in the comments which region you think deserves the title of the best NHL team! #NHL2024 #Hockey #NHLTeams #BestNHLTeam #HockeyAnalysis #Sports #IceHockey #bigapplehockey #bah #nhlbartalk #nhl -For more articles and opinions go to X: www.twitter.com/bigapplehockey-Follow us on INSTAGRAM: https://www.instagram.com/big_apple_hockey_/-Listen to the PODCAST on Apple Podcasts: https://podcasts.apple.com/us/podcast/big-apple-hockey/id1581692698-Listen to the PODCAST on Spotify, iHeartRadio, Google Podcasts -Subscribe on YOUTUBE: www.youtube.com/c/bigapplehockey-For Big Apple Hockey MERCH buy here: https://www.ebay.com/usr/bigapplehockeySupport the channel on TipTopJar: https://tiptopjar.com/bigapplehockeyBAH linktree: https://linktr.ee/bigapplehockeyUse "BigAppleHockey" on Seat Geek for $20 off your first order!Go to Pure Hockey for the BEST hockey equipment! : https://shrtco.de/purehockeybahMarc uses Streamyard for his streaming broadcast! Check them out with this link:https://streamyard.com/?fpr=marc25What are your thoughts? Comment Below! We'd love to hear from you!Want more coverage? Go to www.BAHPod.com for more articles on your favorite teams all around the NHL!Any footage used is considered Fair Use and we do not own the copyright for anything NOT held by us. This video features materials protected by the Fair Use guidelines of Section 107 of the Copyright Act. All rights reserved to the copyright owners.If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800- GAMBLER (1-800-426-2537) (IL/IN/LA/MI/NJ/PA/TN/WV/WY), 1-800- NEXT STEP (AZ), 1-800-522-4700 (CO/NH), 888-789-7777/visit http://ccpg.org (CT), 1-800-BETS OFF (IA), 877-8-HOPENY/text HOPENY (467369) (NY), visit OPGR.org (OR), call/text TN REDLINE 1- 800-889-9789 (TN), or 1-888-532-3500 (VA). 21+ (18+ NH/WY). Physically present in AZ/CO/CT/IL/IN/IA/LA(select parishes)/MI /NJ/NY/PA/TN/VA/WV/WY only. Void in ONT. Valid 1 per new customer. Min. $5 deposit. Min $5 pregame moneyline bet. Bet must win. $150 issued as six (6) $25 free bets. Free Bets are non cashable and cannot be withdrawn. Free bets must be wagered 1x and stake is not included in any returns or winnings. Free Bets expire 7 days (168 hours) after being awarded. Promotional offer period ends 12/30/22 at 11:59pm ET.. See terms at sportsbook.draftkings.com/hockeyterms. NHL and the NHL Shield are registered trademarks of the National Hockey League. © NHL 2022. All Rights ReservedFor more Rangers coverage:Follow John Filkowski on Twitter: @92in82For more Islanders News:Follow Anthony LaRocco on Twitter: @ALaRocco0801

In this exciting video, we take on the ultimate challenge of Building the BEST NHL Team from Each Region in 2024! Join us as we dive into the rich history and talent pool of hockey across North America, analyzing the top players from key regions. From the heart of Canada (Alberta, Ontario, Quebec, Saskatchewan) to the vibrant United States (Michigan, New York, Minnesota, and Massachusetts), we'll explore the unique strengths and styles that each region brings to the ice. Watch as we break down player stats, regional strengths, and fan favorites to assemble a powerhouse team that showcases the best talent from across the NHL landscape. Whether you're a die-hard hockey fan or new to the sport, this video is packed with insights, analysis, and plenty of hockey action! Don't forget to like, comment, and subscribe for more NHL content and let us know in the comments which region you think deserves the title of the best NHL team! #NHL2024 #Hockey #NHLTeams #BestNHLTeam #HockeyAnalysis #Sports #IceHockey #bigapplehockey #bah #nhlbartalk #nhl -For more articles and opinions go to X: www.twitter.com/bigapplehockey -Follow us on INSTAGRAM: https://www.instagram.com/big_apple_hockey_/ -Listen to the PODCAST on Apple Podcasts: https://podcasts.apple.com/us/podcast/big-apple-hockey/id1581692698 -Listen to the PODCAST on Spotify, iHeartRadio, Google Podcasts -Subscribe on YOUTUBE: www.youtube.com/c/bigapplehockey -For Big Apple Hockey MERCH buy here: https://www.ebay.com/usr/bigapplehockey Support the channel on TipTopJar: https://tiptopjar.com/bigapplehockey BAH linktree: https://linktr.ee/bigapplehockey Use "BigAppleHockey" on Seat Geek for $20 off your first order! Go to Pure Hockey for the BEST hockey equipment! : https://shrtco.de/purehockeybah Marc uses Streamyard for his streaming broadcast! Check them out with this link: https://streamyard.com/?fpr=marc25 What are your thoughts? Comment Below! We'd love to hear from you! Want more coverage? Go to www.BAHPod.com for more articles on your favorite teams all around the NHL! Any footage used is considered Fair Use and we do not own the copyright for anything NOT held by us. This video features materials protected by the Fair Use guidelines of Section 107 of the Copyright Act. All rights reserved to the copyright owners. If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800- GAMBLER (1-800-426-2537) (IL/IN/LA/MI/NJ/PA/TN/WV/WY), 1-800- NEXT STEP (AZ), 1-800-522-4700 (CO/NH), 888-789-7777/visit http://ccpg.org (CT), 1-800-BETS OFF (IA), 877-8-HOPENY/text HOPENY (467369) (NY), visit OPGR.org (OR), call/text TN REDLINE 1- 800-889-9789 (TN), or 1-888-532-3500 (VA). 21+ (18+ NH/WY). Physically present in AZ/CO/CT/IL/IN/IA/LA(select parishes)/MI /NJ/NY/PA/TN/VA/WV/WY only. Void in ONT. Valid 1 per new customer. Min. $5 deposit. Min $5 pregame moneyline bet. Bet must win. $150 issued as six (6) $25 free bets. Free Bets are non cashable and cannot be withdrawn. Free bets must be wagered 1x and stake is not included in any returns or winnings. Free Bets expire 7 days (168 hours) after being awarded. Promotional offer period ends 12/30/22 at 11:59pm ET.. See terms at sportsbook.draftkings.com/hockeyterms. NHL and the NHL Shield are registered trademarks of the National Hockey League. © NHL 2022. All Rights Reserved For more Rangers coverage: Follow John Filkowski on Twitter: @92in82 For more Islanders News: Follow Anthony LaRocco on Twitter: @ALaRocco0801 Learn more about your ad choices. Visit megaphone.fm/adchoices

Join Jim Tatti, Dave Feschuk and Michael DiStefano for Hour 1 on OverDrive! Tatti, Feschuk and Al's Brother discuss the Blue Jays' offensive outburst against the Reds, Cole Sillinger's extension with the Blue Jackets and the RFAs around the NHL and Darrell Doucette's claim against Patrick Mahomes' skill. Host of Foul Territory and Former MLBer Erik Kratz joins to discuss the Blue Jays' organization's ceiling, Bo Bichette's future in Toronto and Paul Skenes' case for NL Rookie of the Year, Travis Kelce starring in Happy Gilmore 2 and his role in the film.

TSN Hockey Analyst Martin Biron joined OverDrive to discuss Thatcher Demko entering the season with injury concerns and the x-factor for the Canucks, the Oilers and Blues' offer sheets and the RFAs in the league, the Atlantic Division goaltending rankings, Jeremy Swayman's contract situation, Yaroslav Askarov's potential role with the Predators and more.

TSN Hockey Analyst Martin Biron joined OverDrive to discuss Thatcher Demko entering the season with injury concerns and the x-factor for the Canucks, the Oilers and Blues' offer sheets and the RFAs in the league, the Atlantic Division goaltending rankings, Jeremy Swayman's contract situation, Yaroslav Askarov's potential role with the Predators and more.

During Hour 4 Derek Van Diest from NHL.com joined the show discussing the coming decision on the Oilers' RFAs and the team's trades from Sunday. Hosted on Acast. See acast.com/privacy for more information.

Katie, Papa and Dan return to talk why players sign in Philly forever, what's coming in 2025, which other RFAs re-sign, Michkov vs Torts, developing prospects, a lack of a plan, more!

The Kings got great value on the Quinton Byfield deal. So what happens now with the other massive RFAs who are still without a contract? Who is happy and who is furious out of Lucas Raymond, Seth Jarvis, Martin Necas, Marty Beniers, and Alexis Lafreniere? Plus, the boys break down the best contracts in the NHL NEW EPISODES EVERY MONDAY & WEDNESDAY! SUBSCRIBE TO OUR YOUTUBE: https://www.youtube.com/channel/UCuf52MHW1O7guPMzsMvv2kA FOLLOW US ON INSTAGRAM: https://www.instagram.com/empty.netters/?hl=en FOLLOW US ON TIKTOK: https://www.tiktok.com/@empty.netters (0:00) – Intro (3:33) - Quinton Byfield (5:45) – Lucas Raymond (17:08) – Seth Jarvis & Martin Necas (26:48) - Matty Beniers (33:40) - Alexis Lafreniere (46:20) – 2020 Draft Reorder (51:03) – 10 Best Contracts in the NHL

Today, Fulemin and I do our deep dive of the Leafs' offseason, including the following: A recap of the players, coaches, and front office members who have left the team [0:55] The hiring of Craig Berube [26:43] The re-signings of Max Domi [33:38] and Timothy Liljegren [37:59] The acquisitions of Chris Tanev [42:58], Oliver Ekman-Larsson [59:31], Jani Hakanpaa [1:09:31], Dakota Mermis, and Philippe Myers [1:15:33] The Joseph Woll extension [1:18:40] and Anthony Stolarz signing [1:22:45] The RFAs the Leafs still need to sign (Nick Robertson, Conor Dewar) [1:27:45] The Marner trade the Leafs didn't end up making [1:39:25] Is this team better? [1:48:16]

In this engaging episode of High and Wide Radio, hosts Jim Iacovone and Jack Smith navigate through a myriad of Flyers news and offseason developments. They begin the show with a shoutout to Phans of Philly, emphasizing their unparalleled game day experience packages for Philadelphia sports fans. Visit www.phansofphilly.com for more information As the offseason commences, Jim and Jack dive into the Flyers' recent activities, including the re-signing of RFAs like Yegor Zamula and the first-round pick, Jett Luchanko. The hosts discuss the implications of these signings and what they mean for the team's future. They also hint at a prospect profile on Jack Berglund, the Flyers' second-round pick, to be featured later in the episode. The conversation takes a deeper turn as they address the hot topic: Are the Flyers truly rebuilding? Jim and Jack offer differing perspectives, with Jim advocating for patience and understanding the long-term goals, while Jack expresses concerns about the team's current strategy and the pressure on the 2025 offseason. They debate the potential re-signing of Travis Konecny, weighing the pros and cons of keeping him versus trading him for future assets. Jim and Jack also touch on the Flyers' need for a top-line center and defenseman, discussing the challenges of acquiring such players through trades or the draft. They explore the possibility of targeting Trevor Zegras and the complexities involved in making significant roster changes. The episode wraps up with a focus on the Flyers' draft picks, particularly Jack Berglund. Jim shares his initial impressions of Berglund's gameplay, expressing concerns about his speed and decision-making. The hosts invite listeners to share their thoughts and experiences watching Berglund, fostering an engaging discussion with their audience. Don't miss this thought-provoking episode filled with expert analysis, fan engagement, and all the latest news surrounding the Flyers and the NHL. Subscribe and set alerts for future episodes to stay in the loop! #philadelphiaflyers #philadelphia #flyers #flyershockey

We are about 12 hours away from the beginning of NHL free agency and there are a number of major storylines that are really coming down to the wire. From Steven Stamkos in Tampa Bay to Sam Reinhart in Florida, there are a number of negotiations that are still ongoing that will have a major effect on how things play out on Monday as the market opens up.Jason and Frank kicked off today's podcast by digging into both of those situations. From there, they got into some of the big moves that we got over the weekend, which led them into some talk about the Utah Hockey Club and their blueline reconstruction. Could they keep making moves? Frank seems to think so and he threw in a couple of other teams that could surprise the hockey world on July 1st.They also talked about some intriguing value options including the recently bought-out Jeff Skinner and some non-qualified RFAs who could find ways to bounce back next season.Tyler then swung by for a new edition of Fill in the Blank where he asked the guys about a few teams that have big question marks heading into free agency.After that, they talked about Patrick Kane re-signing in Detroit. The news broke while we were recording, so they gave their thoughts on that and more from around the league to wrap up the podcast.1:05 - Lightning make moves7:55 - Utah's future9:40 - Surprise teams for July 116:45 - The market for Jeff Skinner19:55 - Non-qualified RFAs23:10 - Fill in the Blank35:25 - Expectations in Nashville38:30 - What could the Oilers do?Want to hear more from Frank, Jason and the entire DFO team? Subscribe to our YouTube: https://www.youtube.com/@dailyfaceoff2563You can get involved with all the playoff action over on bet365 by using the promo code DAILY365 at bet365.com Hosted on Acast. See acast.com/privacy for more information.

Sam Driscoll is back with Sam Wallace for this episode as they first talk about some league-wide trades that was made before, during, and after the draft weekend in Las Vegas (4:28). Then they talk about the Hurricanes-side of things when it comes to the draft. They first talk about the biggest news with Guentzel being traded to Tampa (15:13). Then they talk about the RFAs they chose to qualify and see what free agency day looks like for them (24:55). Lastly they give their thoughts on the draft and the selections the Hurricanes made (37:59).If you have any questions or just want to contact us please email us at: thecaniacreport@gmail.comOur Twitter: https://twitter.com/TheCaniacReportOur Instagram: https://www.instagram.com/thecaniacreport/Donation Link: https://paypal.me/sgwallace917?country.x=US&locale.x=en_US

Sam Driscoll is back with Sam Wallace for this episode as they first talk about some league-wide trades that was made before, during, and after the draft weekend in Las Vegas (4:28). Then they talk about the Hurricanes-side of things when it comes to the draft. They first talk about the biggest news with Guentzel being traded to Tampa (15:13). Then they talk about the RFAs they chose to qualify and see what free agency day looks like for them (24:55). Lastly they give their thoughts on the draft and the selections the Hurricanes made (37:59). If you have any questions or just want to contact us please email us at: thecaniacreport@gmail.com Our Twitter: https://twitter.com/TheCaniacReport Our Instagram: https://www.instagram.com/thecaniacreport/ Donation Link: https://paypal.me/sgwallace917?country.x=US&locale.x=en_US Learn more about your ad choices. Visit megaphone.fm/adchoices

Welcome to Jersey Guy Sports, your sports talk home for the Yankees, Giants, Rangers and the Rutgers Scarlet Knights.   I'm your host Don.  Thanks for listening.   Today I'll be discussing:The Rangers season ended Saturday in Florida as tough questions arise for off-season.  The Rangers need more sandpaper, and less east-west play.  I discuss all the tough questions with UFAs and RFAs.  Jersey Guy Sports information: Jersey Guy Sports is available on all podcasting platforms. Start here for links to the podcast on your favorite podcasting platforms. Follow Jersey Guy Sports on Facebook: Facebook Follow Jersey Guy Sports on Twitter: JGS Twitter Follow Don on Twitter: Twitter Follow Don on Threads: Threads Follow Jersey Guy Sports on YouTube : YouTube

Here's our too-early San Jose Sharks' off-season plan!***Quick aside, Keegan's microphone is muffled a bit this episode. We're sorry, everyone! One day, we'll have pristine audio every single time. But not this day. This is kind of like those workplace accident signs where they knock off 100 days since the last accident and replace it with zero. Again. Sigh.***This week, Sheng and Keegan outline some potential off-season moves that could help make the 2024-2025 version of the Sharks be less embarrassing than this year's. (53:45)But before all that, we have a few quick-hitting topics this week (1:15). We start with Will Smith watch: Is he signing or not? (2:30)Sheng and Keegan preview the upcoming May 7th Draft Lottery odds and each run a simulation at Tankathon. Do the Sharks win? (6:10)We highlight what Sheng has heard about some potential candidates for Sharks head coach. (13:15)John McCarthy and the rest of the San Jose Barracuda coaching staff will be returning next season, despite some poor on-ice results. Why do Sheng and Keegan support their return? (29:30)The Sharks want goaltending coach Thomas Speer back, even after David Quinn was let go. (37:21)Finally, we revisit our pre-season bold predictions...how did Sheng and Keegan do? (42:20)Finally, our off-season plan! Which of their free agents should the Sharks keep or let go? Who should they target in the free agency market? Can they make a good trade? (53:45)How much cap and roster space could the San Jose Sharks have? (54:45)Which of the Sharks' UFAs and RFAs will they keep? Who should they allow to walk? (57:45)What's the order of positional need for San Jose this summer? (1:14:33)Let's talk to free agents first -- Sheng has a couple intriguing longshot UFA targets. (1:22:14)Keegan offers a longshot UFA signing at defense. (1:35:55)Then, Keegan shares his favorite lower-end UFA targets. (1:39:00)Sheng has a former Sharks defenseman in mind. (1:41:30)Finally, Keegan offers some forward UFAs with some upside. (1:46:10)That's free agency, how can the San Jose Sharks improve via trade? (1:58:24)Keegan proposes a Mikael Granlund trade. (1:58:44)Going back, Sheng discusses why the Mikey Eyssimont trade was such a mistake, and how the thinking behind the deal helped pave the way for a disastrous 2023-24. (2:03:30)What should Grier's trade philosophy be this summer? (2:16:25)Sheng is prioritizing distressed assets – who are a couple defenseman that the Sharks could target via trade? (2:17:55)How about a trio of center candidates? (2:20:51)Are the San Jose Sharks a better team with a couple of these realistic additions? (2:32:05) ★ Support this podcast ★

On the latest Blackhawks Talk Podcast, Pat Boyle and Charlie Roumeliotis dive into Chicago's pending restricted and unrestricted free agents. Who should be back and who might be let go? Plus, they share their thoughts on Alex Vlasic's six-year extension with the Blackhawks and why it was a win-win for both sides. Also, what will Lukas Reichel's next contract look like? The guys discuss. And finally, what type of players could the Blackhawks target in free agency? Pat and Charlie fire off some names.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode, Rishi breaks down the current contracts, potential franchise tags, RFAs, analytics, and rookies that got drafted. Enjoy as Rishi tries to ruin Nardo's hopes and dreams of getting a steal by exposing as many players and ideas as possible.

Wednesday's episode begins with a discussion on ALL the Chicago Blackhawks' pending restricted and unrestricted free agents & which players could receive contract offers during the 2024 offseason. Then, host Jack Bushman dives into Lukas Reichel joining the IceHogs for their run in the Calder Cup Playoffs, while prospects Alex Pharand and Samuel Savoie have also been assigned to Rockford. The episode concludes with some thoughts on 2022 2nd-round pick (No. 57 overall) Ryan Greene electing to remain in college and return to Boston University for his junior season. All that and more on Locked On Blackhawks. Part of the Locked On Podcast Network. Your Team. Every Day. Hawks RFAs & UFAs (3:20)Reichel, Savoie, & Pharand Join IceHogs (15:50)Greene Returning To BU (26:05) SUBSCRIBE: https://www.youtube.com/@LockedOnBlackhawksPODCAST: https://linktr.ee/JackBushmanTWITTER: https://twitter.com/LO_BlackhawksINSTAGRAM: https://www.instagram.com/lockedonblackhawks/?hl=en  Indeed knows when you're growing your own business, you have to make every dollar count. Visit Indeed.com/LOCKEDON to start hiring now. Download the Sleeper App and use promo code LOCKEDONNHL to get up to a $100 match on your first deposit. Terms and conditions apply. See Sleeper's Terms of Use for details. Download the Gametime app, create an account, and use code LOCKEDON for $20 off your first purchase. Monopoly GO!
Get in the game and join your friends. Download MONOPOLY GO! now free on The App Store or Google Pay. The mobile hit twist on classic MONOPOLY. 
Check life insurance off your to do list in no time with Policygenius. Head to policygenius.com/lockedonnhl to get your free life insurance quotes and see how much you could save. 
For parts that fit, head to eBay Motors and look for the green check. Stay in the game with eBay Guaranteed Fit at eBayMotos.com. Let's ride. eBay Guaranteed Fit only available to US customers. Eligible items only. Exclusions apply. New customers, join today and you'll get TWO HUNDRED DOLLARS in BONUS BETS if your first bet of FIVE DOLLARS or more wins. Visit FanDuel.com/LOCKEDON to get started.FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN)

The Blue Jackets looked lifeless against the Hurricanes last night, but it's to be expected. Malcolm Subban was surprisingly good, and the youth did their best but couldn't solve Freddie Andersen. Plus, it's a mailbag day, so we're talking the biggest offseason question for the Jackets, would I trade Elvis and Provorov for a first round pick if we had to retain salary, which RFAs would I re-sign this offseason, and who the Blue Jackets should draft at 4th overall!Support Us By Supporting Our Sponsors!Factor MealsGet started on your resolutions with Factor, so you're ready for the new year. Head to factormeals.com/lockedonnhl50 and use code lockedonnhl50 to get 50% off plus 20% off your next box. eBay MotorsFor parts that fit, head to eBay Motors and look for the green check. Stay in the game with eBay Guaranteed Fit at eBayMotos.com. Let's ride. eBay Guaranteed Fit only available to US customers. Eligible items only. Exclusions apply.IndeedIndeed knows when you're growing your own business, you have to make every dollar count. Visit Indeed.com/LOCKEDON to start hiring now. PolicygeniusCheck life insurance off your to do list in no time with Policygenius. Head to policygenius.com/lockedonnhl to get your free life insurance quotes and see how much you could save.  SleeperDownload the Sleeper App and use promo code LOCKEDONNHL to get up to a $100 match on your first deposit. Terms and conditions apply. See Sleeper's Terms of Use for details.GametimeDownload the Gametime app, create an account, and use code LOCKEDONNHL for $20 off your first purchase.FanDuelFanDuel, America's Number One Sportsbook. Right now, NEW customers get ONE HUNDRED AND FIFTY DOLLARS in BONUS BETS with any winning GUARENTEED That's A HUNDRED AND FIFTY BUCKS – win or lose! Visit FanDuel.com/LOCKEDON to get started. FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN)

The Calgary Flames might not be looking to make a splash this summer but they still need to ice a team. Which UFAs and RFAs might be the best targets for the Calgary Flames? Which players could the flip at the deadline for more assets? Plus, Jess and Nick discuss the loss of Chris Simon and the implications of denying CTE. Support Us By Supporting Our Sponsors!eBay MotorsFor parts that fit, head to eBay Motors and look for the green check. Stay in the game with eBay Guaranteed Fit at eBayMotos.com. Let's ride. eBay Guaranteed Fit only available to US customers. Eligible items only. Exclusions apply.IndeedIndeed knows when you're growing your own business, you have to make every dollar count. Visit Indeed.com/LOCKEDON to start hiring now. RobinhoodRobinhood has the only IRA that gives you a 3% boost on every dollar you contribute when you subscribe to Robinhood Gold. Now through April 30th, Robinhood is even boosting every single dollar you transfer in from other retirement accounts with a 3% match. Available to U.S. customers in good standing. Robinhood Financial LLC (member SIPC), is a registered broker dealer.SleeperDownload the Sleeper App and use promo code LOCKEDONNHL to get up to a $100 match on your first deposit. Terms and conditions apply. See Sleeper's Terms of Use for details.GametimeDownload the Gametime app, create an account, and use code LOCKEDON for $20 off your first purchase.FanDuelNew customers, join today and you'll get TWO HUNDRED DOLLARS in BONUS BETS if your first bet of FIVE DOLLARS or more wins. Visit FanDuel.com/LOCKEDON to get started. FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN)

The New York Islanders have some difficult decisions ahead of them after standing pat at last week's NHL Trade Deadline. Will Lou Lamoriello decide to extend Brock Nelson this offseason when he is eligible to negotiate one, or do they let him play out the final season of his contract? We also discuss the other players who will be UFAs and RFAs this offseason and debate what the team should do about letting them go or bringing them back.And we have a full preview of tonight's critical game against thew Buffalo Sabres. All this and more on today's Locked On Islanders Podcast with Gil Martin.  Support Us By Supporting Our Sponsors!eBay MotorsFor parts that fit, head to eBay Motors and look for the green check. Stay in the game with eBay Guaranteed Fit at eBayMotos.com. Let's ride. eBay Guaranteed Fit only available to US customers. Eligible items only. Exclusions apply.IbottaIbotta is a free app that gives you the most cash back every time you shop on hundreds of items from groceries to beauty supplies to toys. Right now, Ibotta is offering our listeners $5 just for trying Ibotta by using the code LOCKEDONNHL when you download the free app in the App Store or Google Play store.  RobinhoodRobinhood has the only IRA that gives you a 3% boost on every dollar you contribute when you subscribe to Robinhood Gold. Now through April 30th, Robinhood is even boosting every single dollar you transfer in from other retirement accounts with a 3% match. Available to U.S. customers in good standing. Robinhood Financial LLC (member SIPC), is a registered broker dealer.SleeperDownload the Sleeper App and use promo code LOCKEDONNHL to get up to a $100 match on your first deposit. Terms and conditions apply. See Sleeper's Terms of Use for details.GametimeDownload the Gametime app, create an account, and use code LOCKEDON for $20 off your first purchase.FanDuelGet buckets with your first bet on FanDuel, America's Number One Sportsbook. Right now, NEW customers get ONE HUNDRED AND FIFTY DOLLARS in BONUS BETS with any winning FIVE DOLLAR BET! That's A HUNDRED AND FIFTY BUCKS – if your bet wins! Visit FanDuel.com/LOCKEDON to get started. FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN)

Rumors abound from the NFL Combine as Kirk Cousins to the Atlanta Falcons picks up steam and Justin Fields to the Minnesota Vikings gains some traction. Plus, which QB is most trade-up worthy for the Vikings, and which other combine performers would look great in Purple. Also, which RFAs should the Vikings retain? All on the latest Minnesota Football Party. Find full episodes of The Ron Johnson Show and Team Postcasts on Apple Podcasts: https://podcasts.apple.com/us/podcast/locked-on-sports-minnesota/id1615249036Find full episodes of The Ron Johnson Show and Team Postcasts on Spotify:  https://open.spotify.com/show/2p4adMUTLFgk0l88NjkK5S Visit the Locked On Sports Minnesota HUB at KARE11.com: https://www.kare11.com/lockedon CHECK OUT OUR DAILY TEAM PODCASTS:Locked On Wild: https://podcasts.apple.com/us/podcast/locked-on-wild-your-daily-minnesota-wild-podcast/id1492739918Locked on Wolves: https://podcasts.apple.com/us/podcast/locked-on-wolves-daily-podcast-on-the-minnesota/id1153019457Locked on Vikings: https://podcasts.apple.com/us/podcast/locked-on-vikings-daily-podcast-on-the-minnesota-vikings/id1144153403Locked on Twins: https://podcasts.apple.com/us/podcast/locked-on-twins-daily-podcast-on-the-minnesota-twins/id1349600088Locked on Golden Gophers: https://podcasts.apple.com/us/podcast/locked-on-golden-gophers-daily-podcast-on-minnesota/id1536979266 #MinnesotaVikings --- Support Us By Supporting Our Sponsors!GametimeDownload the Gametime app, create an account, and use code LOCKEDON for $20 off your first purchase.FanDuelNew customers, join today and you'll get TONE HUNDRED AND FIFTY DOLLARS in BONUS BETS if your first bet of FIVE DOLLARS or more wins. Visit FanDuel.com/LOCKEDON to get started.FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN)

Locked on Kraken host Erica L. Ayala uses a very scientific metric to determine the fate of pending Kraken UFAs and RFAs.VIBES!Jokes aside, here is our first pass at who we think should stay or go. PLUS, a quick Kansas City Mavericks check-in.

Locked on Kraken host Erica L. Ayala uses a very scientific metric to determine the fate of pending Kraken UFAs and RFAs. VIBES! Jokes aside, here is our first pass at who we think should stay or go. PLUS, a quick Kansas City Mavericks check-in.

Griff and AB are back for Session 27 at the all-star break to talk about the Canes going 3-0 this past week while examining PLENTY of storylines! After discussing the past week, the guys examine AFPAnalytics NHL Extension Projections for the Canes' 2023-2024 pending UFAs and RFAs. Lastly, Griff sits down with his 8-year-old daughter & HUGE Caniac, Jaxie for a Q&A session about her love of the team. Brought to you by Draft Kings as a member of The Hockey Podcast Network (THPN). Use Promo Code "THPN" when you sign up for Draft Kings. Caniac Sessions is also a promotional partner of Seat Geek. Use Promo Code CANIACSESSIONS to get $20 off your first ticket purchase. Please rate, review, and subscribe! Check us out on X, Instagram, and Facebook @caniacsessions Let's Go Canes!

Griff and AB are back for Session 27 at the all-star break to talk about the Canes going 3-0 this past week while examining PLENTY of storylines! After discussing the past week, the guys examine AFPAnalytics NHL Extension Projections for the Canes' 2023-2024 pending UFAs and RFAs. Lastly, Griff sits down with his 8-year-old daughter & HUGE Caniac, Jaxie for a Q&A session about her love of the team. Brought to you by Draft Kings as a member of The Hockey Podcast Network (THPN). Use Promo Code "THPN" when you sign up for Draft Kings. Caniac Sessions is also a promotional partner of Seat Geek. Use Promo Code CANIACSESSIONS to get $20 off your first ticket purchase. Please rate, review, and subscribe! Check us out on X, Instagram, and Facebook @caniacsessions Let's Go Canes! Learn more about your ad choices. Visit megaphone.fm/adchoices

With Kaapo Kakko off to a disappointing start, does he have a long-term future with the Rangers? And after watching Filip Chytil, Jimmy Vesey and Ben Harpur ink long-term contract extensions in the middle of last season, we're wondering if Kakko and/or other impending unrestricted and restricted free agents will be extended by the Rangers. Will Jonathan Quick stick around as a backup for more than one year? Do the Rangers feel that Nick Bonino will hold up? Has Erik Gustafsson already priced himself out of the Rangers' range? Episode 941. Intro song is "Leave the Lights On" by Passafire.Support Us By Supporting Our Sponsors!eBay MotorsWith all the parts you need at the prices you want, it's easy to turn your car into the MVP and bring home that win. Keep your ride-or-die alive at EbayMotors.com. Eligible items only. Exclusions apply. eBay Guaranteed Fit only available to US customers.Parkview AdvanceFor more than 25 years, Parkview Advance has helped businesses secure working capital. We Invite the many entrepreneurs that are Locked On NHL to learn more by calling us at 203-675-0071 or go to parkviewadvance.com. If your business needs working capital, call Parkview Advance today!SleeperDownload the Sleeper App and use promo code LOCKEDONNHL to get up to a $100 match on your first deposit. Terms and conditions apply. See Sleeper's Terms of Use for details.GametimeToday's episode is brought to you by Gametime.Take the guesswork out of buying tickets with Gametime. Download the Gametime app, create an account, and use code LOCKEDONNHL for $20 off your first purchase.FanDuelScore early this NFL season with FanDuel, America's Number One Sportsbook! Right now, NEW customers get ONE HUNDRED AND FIFTY DOLLARS in BONUS BETS with any winning FIVE DOLLAR MONEYLINE BET! That's A HUNDRED AND FIFTY BUCKS – if your team wins! Visit FanDuel.com/LOCKEDON to get started.FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN)Follow & Subscribe on all Podcast platforms…

With Kaapo Kakko off to a disappointing start, does he have a long-term future with the Rangers? And after watching Filip Chytil, Jimmy Vesey and Ben Harpur ink long-term contract extensions in the middle of last season, we're wondering if Kakko and/or other impending unrestricted and restricted free agents will be extended by the Rangers. Will Jonathan Quick stick around as a backup for more than one year? Do the Rangers feel that Nick Bonino will hold up? Has Erik Gustafsson already priced himself out of the Rangers' range? Episode 941. Intro song is "Leave the Lights On" by Passafire. Support Us By Supporting Our Sponsors! eBay Motors With all the parts you need at the prices you want, it's easy to turn your car into the MVP and bring home that win. Keep your ride-or-die alive at EbayMotors.com. Eligible items only. Exclusions apply. eBay Guaranteed Fit only available to US customers. Parkview Advance For more than 25 years, Parkview Advance has helped businesses secure working capital. We Invite the many entrepreneurs that are Locked On NHL to learn more by calling us at 203-675-0071 or go to parkviewadvance.com. If your business needs working capital, call Parkview Advance today! Sleeper Download the Sleeper App and use promo code LOCKEDONNHL to get up to a $100 match on your first deposit. Terms and conditions apply. See Sleeper's Terms of Use for details. Gametime Today's episode is brought to you by Gametime.Take the guesswork out of buying tickets with Gametime. Download the Gametime app, create an account, and use code LOCKEDONNHL for $20 off your first purchase. FanDuel Score early this NFL season with FanDuel, America's Number One Sportsbook! Right now, NEW customers get ONE HUNDRED AND FIFTY DOLLARS in BONUS BETS with any winning FIVE DOLLAR MONEYLINE BET! That's A HUNDRED AND FIFTY BUCKS – if your team wins! Visit FanDuel.com/LOCKEDON to get started. FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN) Follow & Subscribe on all Podcast platforms…

The one sure thing your law-school loans purchased is instant recall of the fact that “federal courts are courts of limited jurisdiction.”But not as limited today as when you signed your promissory note. We discuss Impossible Foods Inc. v. Impossible X LLC, the recent 9th Circuit decision holding that specific jurisdiction over a defendant may be based on general historical contacts, even though not connected to the claims in the case. Judge Van Dyke dissented, calling the majority's holding “potentially the most radical reimagining and expansion of specific jurisdiction in decades.”We also discuss:Impeachment evidence improperly excluded at trial? Published authority says this is per se reversible, but a new case calls it harmless error. It's not published, but its reasoning is sound.Seeking costs-of-proof attorney fees because your adversary denied your RFAs? Some cases grant these fee motions liberally, but two recent cases caution that more precision is needed.Appealing on a pure issue of law? You still need an oral record on appeal. Denial of petition to compel arbitration affirmed because of the lack of a reporter's transcript.Startling: Ex-husband took out a life insurance policy on wife, naming himself beneficiary. Also startling: Court ordered him to change the beneficiary to wife's favorite charity, and keep the policy current.Uncivil attorney got a 40% fee cut. “Incivility between counsel is sand in the gears. … Excellent lawyers deserve higher fees, and excellent lawyers are civil.”Appellate Specialist Jeff Lewis' biography, LinkedIn profile, and Twitter feed.Appellate Specialist Tim Kowal's biography, LinkedIn profile, Twitter feed, and YouTube page.Sign up for Not To Be Published, Tim Kowal's weekly legal update, or view his blog of recent cases.The California Appellate Law Podcast thanks Casetext for sponsoring the podcast. Listeners receive a discount on Casetext Basic Research at casetext.com/CALP. The co-hosts, Jeff and Tim, were also invited to try Casetext's newest technology, CoCounsel, the world's first AI legal assistant. You can discover CoCounsel for yourself with a demo and free trial at casetext.com/CoCounsel.Other items discussed in the episode:Specific Jurisdiction May Be Based on Past Contacts with Forum, Says 9th Circuit Panel over Judge VanDyke Dissent. Impossible Foods Inc. v. Impossible X LLC, No. 21-16977 (9th Cir. Sep. 12, 2023).Exclusion of critical impeachment evidence held harmless error because the totality of evidence supported the judgment. People v. Bingham (D1d5 Sep. 26, 2023) No. A163112 (nonpub. opn.).Uncivil attorneys get a 40% fee haircut: Snoeck v. ExakTime Innovations, Inc., (D2d3 Oct. 2, 2023) No. B321566 (nonpub. opn.), discussing Karton v. Ari Design & Construction, Inc. (2021) 61 Cal.App.5th 734.Olague v. United Care Facilities, LLC, No. B323075 | CasetextParris J. v. Christopher U. (Oct. 4, 2023, B313470)Videos will be posted at Tim Kowal's YouTube channel.

Will the forthcoming cap increase affect how next year's RFAs handle extension negotiations this season? What does the start of the year look like for Ottawa with Shane Pinto and Josh Norris' statuses uncertain. Brendan Gallagher might be a 4th line player in Montreal. A bevy of 19-year olds are pushing to make difficult decisions for GMs. Minten, Poitras, Benson among them. Ask Ray & Dregs Anything checks in on the Lightning's goalie situation, where Dregs gets his "insider Info" from and if Ray has collected any cherished memorabilia over the years. Then a breakdown of TSN's top 50 players list, with a focus on how Ray would have ranked the top 5.See omnystudio.com/listener for privacy information.

On this episode of The Steve Dangle Podcast, Steve didn't get his money (00:00), You Can Bet That with Sports Interaction (19:00), the top remaining UFAs (25:30), the top remaining RFAs (56:00), Steve Yzerman speaks on Filip Zadina (1:22:30), winners from free agency (1:26:30), losers from free agency (1:34:00), and your Twitter questions! (1:53:00). Recorded: July 5, 2023 Visit https://sdpn.ca for merch and more. Any opinion expressed is not advice, a promise or suggestion that increases the chance of winning. Gambling can be addictive, please play responsibly. To learn more, visit: https://help.sportsinteraction.com/hc/en-us/articles/216779528-Responsible-Gaming-Self-Limitation-Self-Exclusion Or if you have concerns about a gambling problem, call ConnexOntario 1-866-531-2600. Ontario Only. Must be 19+ or older to play. Visit this episode's sponsors: https://sportsinteraction.com/sdpn Follow us on Twitter:@Steve_Dangle, @AdamWylde, & @JesseBlake Follow us on Instagram:@SteveDangle, @AdamWylde, & @Jesse.Blake Reach out to https://www.sdpn.ca/sales to connect with our sales team and discuss the opportunity to integrate your brand within our content! Learn more about your ad choices. Visit megaphone.fm/adchoices

With the signing of Cole Caufield, the first big RFA domino has fallen. How does this change the Avs' approach to signing their own RFAs? The DNVR Avalanche Podcast talks contracts. Learn more about your ad choices. Visit megaphone.fm/adchoices

The Avs have a lot of contract work to do this offseason including a few critical RFA extensions. Should they try to lock up Bowen Byram on a long term deal or would a bridge be better? The DNVR Avalanche Podcast talks RFA contracts. Learn more about your ad choices. Visit megaphone.fm/adchoices