Podcasts about Urs

Urs and Ted have an engaging conversation on the impact of Radical Humility when leading others. Urs shares empowering stories and processes that will help you help others. Ted's favorite part of the book is the idea that we can all be “tough on results and tender on people.”

Hej!Ursäkta att jag stör, men jag tar mig friheten att langa in en liten "mikropodd" här i flödet, egentligen bara för att göra dig som lyssnare uppmärksam på att vi nu har ett ovanligt saftigt och ambitiöst avsnitt tillgängligt på Patreon!I "Kosmos med Christer" tar upp de största av ämnen med allas vår ständigt efterfrågade Christer Engström...För närvarande har vi ett begränsat erbjudande: med koden TILL500 får du som ny patron halva priset på ett årsmedlemskap - men bara tills vi når 500 medlemmar - och det är nära nu!Patreon.com/Virtuellt - hoppas vi hörs där!

Ursäkta förseningen men livet kommer emellan ibland. I det här avsnittet provar vi en riktigt bra bourbon, japp det finns finbourbon också!Skål på er och ha en trevlig WhiskyVecka

Diabetes mellitus ist eine chronische Stoffwechselerkrankung, die durch dauerhaft erhöhte Blutzuckerwerte gekennzeichnet ist. Der Begriff stammt aus dem Griechischen und Lateinischen: Diabetes bedeutet „hindurchfließen“ und mellitus „honigsüß“. Dies beschreibt ein zentrales Merkmal der Krankheit – den vermehrten, zuckerhaltigen Urin, der bereits in der Antike auffiel. Ursächlich liegt eine Störung der Insulinproduktion oder -wirkung vor, wodurch die Regulation des Blutzuckers im Körper gestört ist. Wir werden uns über die nächsten Wochen sehr intensiv mit diesem Krankheitsbild beschäftigen und dich damit fit machen für deine Prüfungen und die praktischen Anleitungen auf Station. Wir gehen auf die unterschiedlichen Formen des Diabetes ein, Medikamentenlehre und natürlich auf jede Menge pflegerische Aspekte.

May 2nd, 2025 marked the 30th anniversary of Dežo Ursíny's passing. This radio show looks at the life and work of this Slovak musical legend, filmmaker, and thinker. With the help of his son Jakub Ursiny, poet Ivan Štrpka, film producer Marián Urban and music journalist Marián Jaslovský we explore what made him so special. From his early music to his deep, personal films, Dežo Ursiny's art still speaks to people today and his legacy remains.

Get in touch with Ultrarunning Sam here ⬅️In this episode of the Home Trails Podcast, I speak to Rebecca Hormann.Last week, Rebecca stormed to victory at the GB ULTRAS Pennine Barrier 50 in 8:45:58, to not only win, but take 4th place overallRebecca is well traveled and holds multiple passports due to her heritage. She grew up in America, then moved to Spain for her soccer career (football), then moved to Malaysia, followed by Northern Ireland, Switzerland and finally good old Blighty!During her travels Rebecca started to run, then the pandemic hit and she really got into running.Since then she's gone from strength to strength, either winning or podiuming in every race she enters! I first met Rebecca at Alston during her Spine Challenger North race back in January, where I mistook her for a Canadian I'd raced with previously! Fortunately, she saw the funny side and didn't hold it against meWe made arrangements to podcast after that race, but due to my poor scheduling its taken until now to sort out!Rebecca was a pleasure to speak to and

Get in touch with Ultrarunning Sam here ⬅️In this episode I speak to the ball of energy and enthusiasm that is Davy Newell!Since 2019 Davy has been putting on The LAP in the Lake District, a 47 mile ultramarathon around lake Windermere.Davy has gradually scaled up the race since its first inception before the pandemic, turning it into one of the UK's most recognised and iconic ultras in the Lakes.This year Davy has stepped up his media presence and next week I will be the official podcast in residence at the 2025 LAP!So in this episode, we meet the man behind the race and dive into his eclectic background. To say Davy has been there, done that, got the T-shirt is a bit of an understatement! Hailing from Northern Ireland, he's traveled around the globe from Africa to south America before finally settling in The Lakes to start a family.His own running was cut short with a diagnosis of multiple sclerosis, which left him with only partial use of one leg. But that didn't stop him from diving into the events organisation business and breaking Guinness world records! We talk about his life up until now, how the LAP got started and his plans for it for the future!URS

Get in touch with Ultrarunning Sam here ⬅️In this episode I speak to returning guest, Scott Jenkins.Scott was last on the show in 2024, when he became the first Brit to complete the Gland Slam of 200's in the US.Since then Scott has moved from the the UK to New Jersey in the States. This gives him access to some of his favourite long course ultramarathons, including his latest race, The Arizona Monster 300!Which as you've guest, is a 300 mile epic ultra across the desert put on by Destination Trails, who recently came under some criticism for how the race was organised and delivered.Scott gives his firsthand experience of the race and defends the organisers and lets us know what actually happened at the inaugural 300 miler.So listen up to find out if he had to 'poop in a bucket'!URS 

Jesse Valencia var en 23-årig student vid University of Missouri i Columbia. Han var ambitiös, omtyckt och hade hela livet framför sig. Men den 5 juni 2004 hittades Jesse brutalt mördad i ett bostadsområde nära campus, bara ett par kvarter från sitt eget hem. Händelsen skakade en hel universitetsstad, och när utredningen tog fart och fler detaljer började framträda, stod det klart att sanningen fanns närmare än någon hade kunnat ana – och att den misstänkte gärningspersonen inte bara kände till utredningen, utan också själv bar uniform. Obs. I början av avsnittet sker en felsägning. Columbia är givetvis en stad, ej delstat. Ursäkta oss! BONUSAVSNITT - "Kvinnan som föll" Via nedan länkar kan du ta del av ett 70 min långt bonusavsnitt om 24-åriga Phoebe Handsjuks bisarra dödsfall efter att ha fallit ned för ett sopnedkast i en lägenhetsbyggnad i Melbourne, Australien år 2010. Spotify: https://open.spotify.com/episode/6ooA2vVarqiEC3wR2mhQnz?si=ZKgUavcZT--T-18Zh82o4g Podcaster: https://podcasts.apple.com/se/podcast/rysarpodden-true-crime/id1455772712?i=1000660725526 Instagram: https://www.instagram.com/rysarpodden/ Facebook: https://www.facebook.com/rysarpodden Mail: rysarpodden@gmail.com

Urs und Beat Kipfer aus Gelterkinden sind kurz davor, das ESC-Maskottchen «Lumo» fertigzustellen. Die Figur, entworfen von der 20-jährigen Kunststudentin Lynn Brunner, schüttelt nächste Woche Regierungspräsident Conradin Cramer die Hand– und ist während der ESC-Woche in der Stadt unterwegs. Ausserdem Thema: · Saint Louis empfiehlt empfindlichen Personen kein Leitungswasser zu trinken wegen Schadstoff PFAS · Basler Kardinal Kurt Koch bei Konklave in Rom dabei · Streckensperrung auf Zuglinie im Laufental startet

Watch this episode featuring Dr. Urs Koenig, leadership expert and author of Radical Humility, to learn how the IDG skill "Humility" can foster stronger relationships, enhance trust, and drive meaningful results through humble leadership.In this compelling conversation, Urs shares insights from his journey—from military service to executive coaching—highlighting how true leadership is about prioritizing the needs of the situation over personal importance. He also emphasizes the value of a growth mindset, transparency, and vulnerability.00:00 Preview00:28 Introduction 01:05 About Dr. Urs Koenig02:36 Urs's Backstory05:13 How the IDG definition of “Humility” resonates with Urs08:04 Motivation behind writing Radical Humility13:08 Why “Humility” is useful in leadership and life17:35 What is a growth mindset?22:13 Business case for humble leadership25:17 The importance of vulnerability in leadership28:50 The role of feedback in humble leadership31:28 The inner work of humble leadership34:39 Urs Koenig's Purposeful Empathy storyCONNECT WITH ANITA✩ Email purposefulempathy@gmail.com ✩ Website https://www.anitanowak.com✩ Buy a copy of Purposeful Empathy http://tiny.cc/PurposefulEmpathyCA✩ LinkedIn https://www.linkedin.com/in/anitanowak/✩ Instagram https://tinyurl.com/anitanowakinstagram✩ Podcast Audio https://tinyurl.com/PurposefulEmpathyPodcast✩ Bluesky https://bsky.app/profile/anitanowak.bsky.socialCONNECT WITH URS✩ LinkedIn https://www.linkedin.com/in/urs-koenig-ab3828/✩ Website https://www.urskoenig.com/✩ Instagram https://www.instagram.com/koenigurs/?hl=enSHOW NOTES✩ Inner Development Goals✩ Radical HumilityVideo edited by Green Horizon Studio

Logiciel dans l'industrie pharma : et si on parlait vraiment du processus ? On vous a déjà demandé votre avis sur la conception ou la validation d'un logiciel dans l'industrie pharmaceutique ? Vous avez participé au déploiement d'un nouveau logiciel ? À la rédaction d'un URS ? À une montée de version ? ERP, LIMS, QMS... ? Moi, oui. Plusieurs fois. Et à chaque fois… j'ai été un peu déçu.

I had the pleasure of sitting down again with Urs Leonhardt Steiner, the Swiss-born conductor and founder of the Golden Gate Symphony Orchestra & Chorus, a truly unique and inspiring musical ensemble based in San Francisco. For over 33 years, this orchestra has been more than a performance group — it's been a community mission. Urs has a gift for making classical music feel alive and relevant. He talks to the audience during presentations in both English and Spanish, making sure audiences from all backgrounds feel welcome and engaged. At every concert, he shares the stories behind the music, offering context that makes even the most complex works approachable and meaningful. One of the most remarkable aspects of the Golden Gate Symphony is its inclusive structure: about half of the musicians are professionals, and the other half are highly talented non-professionals who bring the same level of passion and excellence. This is by design — the orchestra's mission has always been to open the world of music to everyone, not just the elite. And that mission extends to the audience, too. Every concert includes free tickets for Spanish-speaking families and local community members, making world-class music accessible to neighbors who might not otherwise have the opportunity. Mark your calendars for [...]

Tuve el placer de entrevistar a Urs Leonhard Steiner, director suizo y fundador de la Golden Gate Symphony Orchestra & Chorus, una orquesta que lleva 33 años transformando vidas a través de la música. Urs no solo dirige con pasión, sino que también comparte sus conciertos en inglés y español, explicando las historias y emociones detrás de cada pieza, haciéndolas accesibles y cercanas para todos. Desde su creación, esta orquesta ha mantenido una misión clara: hacer que la música clásica sea una experiencia abierta y accesible para toda la comunidad. La mitad de sus músicos son profesionales, y la otra mitad no lo son, pero todos comparten una calidad y compromiso excepcionales. Esta mezcla única refleja su espíritu comunitario: unir talento y corazón para compartir arte de alto nivel. Una de las cosas más hermosas que hablamos en esta entrevista es que en cada concierto ofrecen algunas entradas gratuitas a familias hispanas y vecinas, para que puedan disfrutar de música clásica de gran calidad sin barreras económicas o de idioma. Es un gesto poderoso que promueve la inclusión cultural y la equidad en el acceso a las artes. No se pierdan su próximo concierto: “SHOSTAKOVICH 5: A Soviet Artist's Reply to Criticism”, con un programa profundamente conmovedor [...]

Get in touch with Ultrarunning Sam here ⬅️This is a solo news episode.I opine on Northern Traverse results, who's going to Western States, the controversies surrounding Destination Trails race, The Monster 300 and what's being said about it on social media and Reddit.I also chat about my recent race at Ranger Ultras PB137 and and how I rolled my ankle 3 times, threw up 4 times, but still managed to hold onto 2nd place!URS  

In ihrer ersten gemeinsamen Podcast-Folge nehmen dich Thomas und Urs mit auf eine inspirierende Reise in die Welt der professionellen Marktgärtnerei. Zwei unterschiedliche Wege, die zeigen: Der Schritt in die naturnahe Landwirtschaft kann auf vielfältige Weise gelingen. Das erwartet dich: o Wertvolle Perspektiven aus zwei Welten: • Thomas: Von der Konzernkarriere zum erfolgreichen Market Gardening • Urs: Expertise aus Demeter-Ausbildung und ökologischer Landwirtschaft o Praxiserprobte Einblicke in: • Unternehmerisches Mindset für Marktgärtner:innen • Die Verbindung von Business-Knowhow und naturnahem Wirtschaften • Persönliche Entwicklung als Unternehmer:in o Konkrete Erkenntnisse für deinen Weg: • Herausforderungen und Chancen der Gründung • Erfolgsstrategien aus der Praxis • Aktuelle Entwicklungen der Market Garden-Bewegung Diese Episode zeigt dir: eine erfüllende Lebensgrundlage und naturnahes Wirtschaften können Hand in Hand gehen. Lass dich von zwei erfahrenen Praktikern auf deinem Weg in die Marktgartnerei begleiten.

Get in touch with Ultrarunning Sam here ⬅️This episode is an emotional one, so be prepared!Luke talks about the moment as a 24 year old, that he now says was the end of everything he ever knew to be right with the world. The moment he was diagnosed with terminal cancer.Having ignored a nagging pain in his shoulder for nearly 6 months, he finally went to the doctors and found that he had a tumour the size of a mango under his shoulder blade, as well as multiple metastasis in his lungs.Rather than wallow in sadness, (which nobody could have denied him) he did what he could during his treatment. Cycling on a stationary bike for a hour and walking around Bristol Harbour for an hour. He even managed to start running and somehow ran a half marathon in 80 minutes during his treatment! After treatment he upped his cardio and cycled from Bristol to Beijing on a tandem bike! (see the film 'A life in tandem")From there he realised that he had a diesel engine and turned his attention to trail and ultra. Wnning his first ultra in Wicklow Ireland and then a sky running race, all within 2 weeks! From there he has won Golden Trail races, races by UTMB and it seems there's no stopping him now!Lukes life may have been marred by tragedy, but his upbeat and positive attitude seem to exude from him and you can't help but be inspired!Good things to come for this lad from the South West!URS

Get in touch with Ultrarunning Sam here ⬅️In this podcast we speak to returning guest Fiona Pascall.Fi is back for a third time to talk about her recent success at Chianti by UTMB.Fi beat some of the best international ultra runners to win the race and secure her golden ticket to the big dance in Auburn for Western States this June.Although she is undecided about wether to take the ticket to WSER, we all know its probably to most likely outcome as even she admits that it could be a once in a lifetime situation. We talk about her training leading into the race, how it went on the day and how it didn't feel like a decisive win for her, even with a 19 minute gap over 2nd place.We also dive into her new project, Trail Retreats, to hear about the long term plan that Fi and her partner Matt have for the running camp that recently came to fruition.We can't wait to see how she does toeing the line at WSER in just a few short months!URS

Die frühen Mönche klebten sich Kerzenstummel auf den Daumennagel, wenn sie nachts in einer dunklen Kirche ihre Gebete lasen. Urs von Wulfen bedenkt Redewendungen christlichen Ursprungs.

Die frühen Mönche klebten sich Kerzenstummel auf den Daumennagel, wenn sie nachts in einer dunklen Kirche ihre Gebete lasen. Urs von Wulfen bedenkt Redewendungen christlichen Ursprungs.

Die frühen Mönche klebten sich Kerzenstummel auf den Daumennagel, wenn sie nachts in einer dunklen Kirche ihre Gebete lasen. Urs von Wulfen bedenkt Redewendungen christlichen Ursprungs.

I'm back, baby. I've been away traveling for podcasts and am excited to bring you new ones with Michael Levin, William Hahn, Robin Hanson, and Emily Riehl, coming up shortly. They're already recorded. I've been recovering from a terrible flu but pushed through it to bring you today's episode with Urs Schreiber. This one is quite mind-blowing. It's quite hairy mathematics, something called higher category theory, and how using this math (which examines the structure of structure) allows one manner of finding "something" from "nothing." Here, "nothing" means the empty set, and "something" is defined as fermions and even 11D supergravity. It's the first time this material has been presented in this manner. Enjoy. NOTE: Link to technical details are here from Urs Schreiber: https://ncatlab.org/schreiber/show/Peri+Pantheorias As a listener of TOE you can get a special 20% off discount to The Economist and all it has to offer! Visit https://www.economist.com/toe Join My New Substack (Personal Writings): https://curtjaimungal.substack.com Listen on Spotify: https://tinyurl.com/SpotifyTOE Become a YouTube Member (Early Access Videos): https://www.youtube.com/channel/UCdWIQh9DGG6uhJk8eyIFl1w/join Links Mentioned: - nLab website: https://ncatlab.org/nlab/show/HomePage - Paper on category theory: https://people.math.osu.edu/cogdell.1/6112-Eilenberg&MacLane-www.pdf - “Higher Topos Theory for Physics” (Urs's talk): https://www.youtube.com/watch?v=GD20W6vxMI4 - “Higher Topos Theory for Physics” (Urs's paper): https://arxiv.org/pdf/2311.11026 - Stephen Wolfram on TOE: https://www.youtube.com/watch?v=0YRlQQw0d-4 - Feynman's thesis: https://faculty.washington.edu/seattle/physics541/2012-path-integrals/thesis.pdf - Differential cohomology in a cohesive ∞-topos (Urs's paper): https://arxiv.org/pdf/1310.7930 - M-Theory from the Superpoint (paper): https://arxiv.org/pdf/1702.01774 - Character Map in Non-Abelian Cohomology, The: Twisted, Differential, and Generalized (textbook): https://amzn.to/4bFuz7H - TOE's String Theory Iceberg: https://www.youtube.com/watch?v=X4PdPnQuwjY Timestamps: 00:00 Introduction 01:27 The Creation of nLab 04:36 Philosophy Meets Physics 07:55 The Role of Mathematical Language 09:32 Emergence from Nothing 16:25 Towards a Theory of Everything 22:21 The Problem with Modern Physics 25:31 Diving into Category Theory 35:30 Understanding Adjunctions 41:46 The Significance of Duality 52:54 Exploring Toposes 1:14:20 The UNEDA Lemma and Generalized Spaces 1:16:37 Charts in Physics 1:20:55 Introduction to Infinitesimal Disks 1:23:56 The Emergence of Supergeometry 1:27:33 Transitioning to Gauge Theories 1:28:11 Exploring Singularities in Physics 1:32:50 The Role of Superformal Spaces 1:36:44 Functors and Their Implications 1:40:51 From Nothing to Emergent Structures 1:43:04 Hegel's Influence on Modern Physics 1:54:07 Discovering Higher-Dimensional Structures 1:56:30 The Path to 11-Dimensional Supergravity 1:57:21 Universal Central Extensions 2:03:21 The Journey to M-Theory 2:11:19 Globalizing the Structure of Supergravity 2:15:36 Understanding Global Charges in Physics 2:23:31 Dirac's Insights into Gauge Potentials 2:30:21 The Quest for Non-Perturbative Physics 2:39:04 Conclusion Support TOE on Patreon: https://patreon.com/curtjaimungal Twitter: https://twitter.com/TOEwithCurt Discord Invite: https://discord.com/invite/kBcnfNVwqs #science #theoreticalphysics Learn more about your ad choices. Visit megaphone.fm/adchoices

Die frühen Mönche klebten sich Kerzenstummel auf den Daumennagel, wenn sie nachts in einer dunklen Kirche ihre Gebete lasen. Urs von Wulfen bedenkt Redewendungen christlichen Ursprungs.

Die frühen Mönche klebten sich Kerzenstummel auf den Daumennagel, wenn sie nachts in einer dunklen Kirche ihre Gebete lasen. Urs von Wulfen bedenkt Redewendungen christlichen Ursprungs.

“Eventually, my dream would be to simulate a virtual cell.”—Demis HassabisThe aspiration to build the virtual cell is considered to be equivalent to a moonshot for digital biology. Recently, 42 leading life scientists published a paper in Cell on why this is so vital, and how it may ultimately be accomplished. This conversation is with 2 of the authors, Charlotte Bunne, now at EPFL and Steve Quake, a Professor at Stanford University, who heads up science at the Chan-Zuckerberg Initiative The audio (above) is available on iTunes and Spotify. The full video is linked here, at the top, and also can be found on YouTube.TRANSCRIPT WITH LINKS TO AUDIO Eric Topol (00:06):Hello, it's Eric Topol with Ground Truths and we've got a really hot topic today, the virtual cell. And what I think is extraordinarily important futuristic paper that recently appeared in the journal Cell and the first author, Charlotte Bunne from EPFL, previously at Stanford's Computer Science. And Steve Quake, a young friend of mine for many years who heads up the Chan Zuckerberg Initiative (CZI) as well as a professor at Stanford. So welcome, Charlotte and Steve.Steve Quake (00:42):Thanks, Eric. It's great to be here.Charlotte Bunne:Thanks for having me.Eric Topol (00:45):Yeah. So you wrote this article that Charlotte, the first author, and Steve, one of the senior authors, appeared in Cell in December and it just grabbed me, “How to build the virtual cell with artificial intelligence: Priorities and opportunities.” It's the holy grail of biology. We're in this era of digital biology and as you point out in the paper, it's a convergence of what's happening in AI, which is just moving at a velocity that's just so extraordinary and what's happening in biology. So maybe we can start off by, you had some 42 authors that I assume they congregated for a conference or something or how did you get 42 people to agree to the words in this paper?Steve Quake (01:33):We did. We had a meeting at CZI to bring community members together from many different parts of the community, from computer science to bioinformatics, AI experts, biologists who don't trust any of this. We wanted to have some real contrarians in the mix as well and have them have a conversation together about is there an opportunity here? What's the shape of it? What's realistic to expect? And that was sort of the genesis of the article.Eric Topol (02:02):And Charlotte, how did you get to be drafting the paper?Charlotte Bunne (02:09):So I did my postdoc with Aviv Regev at Genentech and Jure Leskovec at CZI and Jure was part of the residency program of CZI. And so, this is how we got involved and you had also prior work with Steve on the universal cell embedding. So this is how everything got started.Eric Topol (02:29):And it's actually amazing because it's a who's who of people who work in life science, AI and digital biology and omics. I mean it's pretty darn impressive. So I thought I'd start off with a quote in the article because it kind of tells a story of where this could go. So the quote was in the paper, “AIVC (artificial intelligence virtual cell) has the potential to revolutionize the scientific process, leading to future breakthroughs in biomedical research, personalized medicine, drug discovery, cell engineering, and programmable biology.” That's a pretty big statement. So maybe we can just kind of toss that around a bit and maybe give it a little more thoughts and color as to what you were positing there.Steve Quake (03:19):Yeah, Charlotte, you want me to take the first shot at that? Okay. So Eric, it is a bold claim and we have a really bold ambition here. We view that over the course of a decade, AI is going to provide the ability to make a transformative computational tool for biology. Right now, cell biology is 90% experimental and 10% computational, roughly speaking. And you've got to do just all kinds of tedious, expensive, challenging lab work to get to the answer. And I don't think AI is going to replace that, but it can invert the ratio. So within 10 years I think we can get to biology being 90% computational and 10% experimental. And the goal of the virtual cell is to build a tool that'll do that.Eric Topol (04:09):And I think a lot of people may not understand why it is considered the holy grail because it is the fundamental unit of life and it's incredibly complex. It's not just all the things happening in the cell with atoms and molecules and organelles and everything inside, but then there's also the interactions the cell to other cells in the outside tissue and world. So I mean it's really quite extraordinary challenge that you've taken on here. And I guess there's some debate, do we have the right foundation? We're going to get into foundation models in a second. A good friend of mine and part of this whole I think process that you got together, Eran Segal from Israel, he said, “We're at this tipping point…All the stars are aligned, and we have all the different components: the data, the compute, the modeling.” And in the paper you describe how we have over the last couple of decades have so many different data sets that are rich that are global initiatives. But then there's also questions. Do we really have the data? I think Bo Wang especially asked about that. Maybe Charlotte, what are your thoughts about data deficiency? There's a lot of data, but do you really have what we need before we bring them all together for this kind of single model that will get us some to the virtual cell?Charlotte Bunne (05:41):So I think, I mean one core idea of building this AIVC is that we basically can leverage all experimental data that is overall collected. So this also goes back to the point Steve just made. So meaning that we basically can integrate across many different studies data because we have AI algorithms or the architectures that power such an AIVC are able to integrate basically data sets on many different scales. So we are going a bit away from this dogma. I'm designing one algorithm from one dataset to this idea of I have an architecture that can take in multiple dataset on multiple scales. So this will help us a bit in being somewhat efficient with the type of experiments that we need to make and the type of experiments we need to conduct. And again, what Steve just said, ultimately, we can very much steer which data sets we need to collect.Charlotte Bunne (06:34):Currently, of course we don't have all the data that is sufficient. I mean in particular, I think most of the tissues we have, they are healthy tissues. We don't have all the disease phenotypes that we would like to measure, having patient data is always a very tricky case. We have mostly non-interventional data, meaning we have very limited understanding of somehow the effect of different perturbations. Perturbations that happen on many different scales in many different environments. So we need to collect a lot here. I think the overall journey that we are going with is that we take the data that we have, we make clever decisions on the data that we will collect in the future, and we have this also self-improving entity that is aware of what it doesn't know. So we need to be able to understand how well can I predict something on this somewhat regime. If I cannot, then we should focus our data collection effort into this. So I think that's not a present state, but this will basically also guide the future collection.Eric Topol (07:41):Speaking of data, one of the things I think that's fascinating is we saw how AlphaFold2 really revolutionized predicting proteins. But remember that was based on this extraordinary resource that had been built, the Protein Data Bank that enabled that. And for the virtual cell there's no such thing as a protein data bank. It's so much more as you emphasize Charlotte, it's so much dynamic and these perturbations that are just all across the board as you emphasize. Now the human cell atlas, which currently some tens of millions, but going into a billion cells, we learned that it used to be 200 cell types. Now I guess it's well over 5,000 and that we have 37 trillion cells approximately in the average person adult's body is a formidable map that's being made now. And I guess the idea that you're advancing is that we used to, and this goes back to a statement you made earlier, Steve, everything we did in science was hypothesis driven. But if we could get computational model of the virtual cell, then we can have AI exploration of the whole field. Is that really the nuts of this?Steve Quake (09:06):Yes. A couple thoughts on that, maybe Theo Karaletsos, our lead AI person at CZI says machine learning is the formalism through which we understand high dimensional data and I think that's a very deep statement. And biological systems are intrinsically very high dimensional. You've got 20,000 genes in the human genome in these cell atlases. You're measuring all of them at the same time in each single cell. And there's a lot of structure in the relationships of their gene expression there that is just not evident to the human eye. And for example, CELL by GENE, our database that collects all the aggregates, all of the single cell transcriptomic data is now over a hundred million cells. And as you mentioned, we're seeing ways to increase that by an order of magnitude in the near future. The project that Jure Leskovec and I worked on together that Charlotte referenced earlier was like a first attempt to build a foundational model on that data to discover some of the correlations and structure that was there.Steve Quake (10:14):And so, with a subset, I think it was the 20 or 30 million cells, we built a large language model and began asking it, what do you understand about the structure of this data? And it kind of discovered lineage relationships without us teaching it. We trained on a matrix of numbers, no biological information there, and it learned a lot about the relationships between cell type and lineage. And that emerged from that high dimensional structure, which was super pleasing to us and really, I mean for me personally gave me the confidence to say this stuff is going to work out. There is a future for the virtual cell. It's not some made up thing. There is real substance there and this is worth investing an enormous amount of CZIs resources in going forward and trying to rally the community around as a project.Eric Topol (11:04):Well yeah, the premise here is that there is a language of life, and you just made a good case that there is if you can predict, if you can query, if you can generate like that. It is reminiscent of the famous Go game of Lee Sedol, that world champion and how the machine came up with a move (Move 37) many, many years ago that no human would've anticipated and I think that's what you're getting at. And the ability for inference and reason now to add to this. So Charlotte, one of the things of course is about, well there's two terms in here that are unfamiliar to many of the listeners or viewers of this podcast, universal representations (UR) and virtual instrument (VIs) that you make a pretty significant part of how you are going about this virtual cell model. So could you describe that and also the embeddings as part of the universal representation (UR) because I think embeddings, or these meaningful relationships are key to what Steve was just talking about.Charlotte Bunne (12:25):Yes. So in order to somewhat leverage very different modalities in order to leverage basically modalities that will take measurements across different scales, like the idea is that we have large, may it be transformer models that might be very different. If I have imaging data, I have a vision transformer, if I have a text data, I have large language models that are designed of course for DNA then they have a very wide context and so on and so forth. But the idea is somewhat that we have models that are connected through the scales of biology because those scales we know. We know which components are somewhat involved or in measurements that are happening upstream. So we have the somewhat interconnection or very large model that will be trained on many different data and we have this internal model representation that somewhat capture everything they've seen. And so, this is what we call those universal representation (UR) that will exist across the scales of biology.Charlotte Bunne (13:22):And what is great about AI, and so I think this is a bit like a history of AI in short is the ability to predict the last years, the ability to generate, we can generate new hypothesis, we can generate modalities that we are missing. We can potentially generate certain cellular state, molecular state have a certain property, but I think what's really coming is this ability to reason. So we see this in those very large language models, the ability to reason about a hypothesis, how we can test it. So this is what those instruments ultimately need to do. So we need to be able to simulate the change of a perturbation on a cellular phenotype. So on the internal representation, the universal representation of a cell state, we need to simulate the fact the mutation has downstream and how this would propagate in our representations upstream. And we need to build many different type of virtual instruments that allow us to basically design and build all those capabilities that ultimately the AI virtual cell needs to possess that will then allow us to reason, to generate hypothesis, to basically predict the next experiment to conduct to predict the outcome of a perturbation experiment to in silico design, cellular states, molecular states, things like that. And this is why we make the separation between internal representation as well as those instruments that operate on those representations.Eric Topol (14:47):Yeah, that's what I really liked is that you basically described the architecture, how you're going to do this. By putting these URs into the VIs, having a decoder and a manipulator and you basically got the idea if you can bring all these different integrations about which of course is pending. Now there are obviously many naysayers here that this is impossible. One of them is this guy, Philip Ball. I don't know if you read the language, How Life Works. Now he's a science journalist and he's a prolific writer. He says, “Comparing life to a machine, a robot, a computer, sells it short. Life is a cascade of processes, each with a distinct integrity and autonomy, the logic of which has no parallel outside the living world.” Is he right? There's no way to model this. It's silly, it's too complex.Steve Quake (15:50):We don't know, alright. And it's great that there's naysayers. If everyone agreed this was doable, would it be worth doing? I mean the whole point is to take risks and get out and do something really challenging in the frontier where you don't know the answer. If we knew that it was doable, I wouldn't be interested in doing it. So I personally am happy that there's not a consensus.Eric Topol (16:16):Well, I mean to capture people's imagination here, if you're successful and you marshal a global effort, I don't know who's going to pay for it because it's a lot of work coming here going forward. But if you can do it, the question here is right today we talk about, oh let's make an organoid so we can figure out how to treat this person's cancer or understand this person's rare disease or whatever. And instead of having to wait weeks for this culture and all the expense and whatnot, you could just do it in a computer and in silico and you have this virtual twin of a person's cells and their tissue and whatnot. So the opportunity here is, I don't know if people get, this is just extraordinary and quick and cheap if you can get there. And it's such a bold initiative idea, who will pay for this do you think?Steve Quake (17:08):Well, CZI is putting an enormous amount of resources into it and it's a major project for us. We have been laying the groundwork for it. We recently put together what I think is if not the largest, one of the largest GPU supercomputer clusters for nonprofit basic science research that came online at the end of last year. And in fact in December we put out an RFA for the scientific community to propose using it to build models. And so we're sharing that resource within the scientific community as I think you appreciate, one of the real challenges in the field has been access to compute resources and industry has it academia at a much lower level. We are able to be somewhere in between, not quite at the level of a private company but the tech company but at a level beyond what most universities are being able to do and we're trying to use that to drive the field forward. We're also planning on launching RFAs we this year to help drive this project forward and funding people globally on that. And we are building a substantial internal effort within CZI to help drive this project forward.Eric Topol (18:17):I think it has the looks of the human genome project, which at time as you know when it was originally launched that people thought, oh, this is impossible. And then look what happened. It got done. And now the sequence of genome is just a commodity, very relatively, very inexpensive compared to what it used to be.Steve Quake (18:36):I think a lot about those parallels. And I will say one thing, Philip Ball, I will concede him the point, the cells are very complicated. The genome project, I mean the sort of genius there was to turn it from a biology problem to a chemistry problem, there is a test tube with a chemical and it work out the structure of that chemical. And if you can do that, the problem is solved. I think what it means to have the virtual cell is much more complex and ambiguous in terms of defining what it's going to do and when you're done. And so, we have our work cut out for us there to try to do that. And that's why a little bit, I established our North Star and CZI for the next decade as understanding the mysteries of the cell and that word mystery is very important to me. I think the molecules, as you pointed out earlier are understood, genome sequenced, protein structure solved or predicted, we know a lot about the molecules. Those are if not solved problems, pretty close to being solved. And the real mystery is how do they work together to create life in the cell? And that's what we're trying to answer with this virtual cell project.Eric Topol (19:43):Yeah, I think another thing that of course is happening concurrently to add the likelihood that you'll be successful is we've never seen the foundation models coming out in life science as they have in recent weeks and months. Never. I mean, I have a paper in Science tomorrow coming out summarizing the progress about not just RNA, DNA, ligands. I mean the whole idea, AlphaFold3, but now Boltz and so many others. It's just amazing how fast the torrent of new foundation models. So Charlotte, what do you think accounts for this? This is unprecedented in life science to see foundation models coming out at this clip on evolution on, I mean you name it, design of every different molecule of life or of course in cells included in that. What do you think is going on here?Charlotte Bunne (20:47):So on the one hand, of course we benefit profits and inherit from all the tremendous efforts that have been made in the last decades on assembling those data sets that are very, very standardized. CELLxGENE is very somehow AI friendly, as you can say, it is somewhat a platform that is easy to feed into algorithms, but at the same time we actually also see really new building mechanisms, design principles of AI algorithms in itself. So I think we have understood that in order to really make progress, build those systems that work well, we need to build AI tools that are designed for biological data. So to give you an easy example, if I use a large language model on text, it's not going to work out of the box for DNA because we have different reading directions, different context lens and many, many, many, many more.Charlotte Bunne (21:40):And if I look at standard computer vision where we can say AI really excels and I'm applying standard computer vision, vision transformers on multiplex images, they're not going to work because normal computer vision architectures, they always expect the same three inputs, RGB, right? In multiplex images, I'm measuring up to 150 proteins potentially in a single experiment, but every study will measure different proteins. So I deal with many different scales like larger scales and I used to attention mechanisms that we have in usual computer vision. Transformers are not going to work anymore, they're not going to scale. And at the same time, I need to be completely flexible in whatever input combination of channel I'm just going to face in this experiment. So this is what we right now did for example, in our very first work, inheriting the design principle that we laid out in the paper AI virtual cell and then come up with new AI architectures that are dealing with these very special requirements that biological data have.Charlotte Bunne (22:46):So we have now a lot of computer scientists that work very, very closely have a very good understanding of biologists. Biologists that are getting much and much more into the computer science. So people who are fluent in both languages somewhat, that are able to now build models that are adopted and designed for biological data. And we don't just take basically computer vision architectures that work well on street scenes and try to apply them on biological data. So it's just a very different way of thinking about it, starting constructing basically specialized architectures, besides of course the tremendous data efforts that have happened in the past.Eric Topol (23:24):Yeah, and we're not even talking about just sequence because we've also got imaging which has gone through a revolution, be able to image subcellular without having to use any types of stains that would disrupt cells. That's another part of the deep learning era that came along. One thing I thought was fascinating in the paper in Cell you wrote, “For instance, the Short Read Archive of biological sequence data holds over 14 petabytes of information, which is 1,000 times larger than the dataset used to train ChatGPT.” I mean that's a lot of tokens, that's a lot of stuff, compute resources. It's almost like you're going to need a DeepSeek type of way to get this. I mean not that DeepSeek as its claim to be so much more economical, but there's a data challenge here in terms of working with that massive amount that is different than the human language. That is our language, wouldn't you say?Steve Quake (24:35):So Eric, that brings to mind one of my favorite quotes from Sydney Brenner who is such a wit. And in 2000 at the sort of early first flush of success in genomics, he said, biology is drowning in a sea of data and starving for knowledge. A very deep statement, right? And that's a little bit what the motivation was for putting the Short Read Archive statistic into the paper there. And again, for me, part of the value of this endeavor of creating a virtual cell is it's a tool to help us translate data into knowledge.Eric Topol (25:14):Yeah, well there's two, I think phenomenal figures in your Cell paper. The first one that kicks across the capabilities of the virtual cell and the second that compares the virtual cell to the real or the physical cell. And we'll link that with this in the transcript. And the other thing we'll link is there's a nice Atlantic article, “A Virtual Cell Is a ‘Holy Grail' of Science. It's Getting Closer.” That might not be quite close as next week or year, but it's getting close and that's good for people who are not well grounded in this because it's much more taken out of the technical realm. This is really exciting. I mean what you're onto here and what's interesting, Steve, since I've known you for so many years earlier in your career you really worked on omics that is being DNA and RNA and in recent times you've made this switch to cells. Is that just because you're trying to anticipate the field or tell us a little bit about your migration.Steve Quake (26:23):Yeah, so a big part of my career has been trying to develop new measurement technologies that'll provide insight into biology. And decades ago that was understanding molecules. Now it's understanding more complex biological things like cells and it was like a natural progression. I mean we built the sequencers, sequenced the genomes, done. And it was clear that people were just going to do that at scale then and create lots of data. Hopefully knowledge would get out of that. But for me as an academic, I never thought I'd be in the position I'm in now was put it that way. I just wanted to keep running a small research group. So I realized I would have to get out of the genome thing and find the next frontier and it became this intersection of microfluidics and genomics, which as you know, I spent a lot of time developing microfluidic tools to analyze cells and try to do single cell biology to understand their heterogeneity. And that through a winding path led me to all these cell atlases and to where we are now.Eric Topol (27:26):Well, we're fortunate for that and also with your work with CZI to help propel that forward and I think it sounds like we're going to need a lot of help to get this thing done. Now Charlotte, as a computer scientist now at EPFL, what are you going to do to keep working on this and what's your career advice for people in computer science who have an interest in digital biology?Charlotte Bunne (27:51):So I work in particular on the prospect of using this to build diagnostic tools and to make diagnostics in the clinic easier because ultimately we have somewhat limited capabilities in the hospital to run deep omics, but the idea of being able to somewhat map with a cheaper and lighter modality or somewhat diagnostic test into something much richer because a model has been seeing all those different data and can basically contextualize it. It's very interesting. We've seen all those pathology foundation models. If I can always run an H&E, but then decide when to run deeper diagnostics to have a better or more accurate prediction, that is very powerful and it's ultimately reducing the costs, but the precision that we have in hospitals. So my faculty position right now is co-located between the School of Life Sciences, School of Computer Science. So I have a dual affiliation and I'm affiliated to the hospitals to actually make this possible and as a career advice, I think don't be shy and stick to your discipline.Charlotte Bunne (28:56):I have a bachelor's in biology, but I never only did biology. I have a PhD in computer science, which you would think a bachelor in biology not necessarily qualifies you through. So I think this interdisciplinarity also requires you to be very fluent, very comfortable in reading many different styles of papers and publications because a publication in a computer science venue will be very, very different from the way we write in biology. So don't stick to your study program, but just be free in selecting whatever course gets you closer to the knowledge you need in order to do the research or whatever task you are building and working on.Eric Topol (29:39):Well, Charlotte, the way you're set up there with this coalescence of life science and computer science is so ideal and so unusual here in the US, so that's fantastic. That's what we need and that's really the underpinning of how you're going to get to the virtual cells, getting these two communities together. And Steve, likewise, you were an engineer and somehow you became one of the pioneers of digital biology way back before it had that term, this interdisciplinary, transdisciplinary. We need so much of that in order for you all to be successful, right?Steve Quake (30:20):Absolutely. I mean there's so much great discovery to be done on the boundary between fields. I trained as a physicist and kind of made my career this boundary between physics and biology and technology development and it's just sort of been a gift that keeps on giving. You've got a new way to measure something, you discover something new scientifically and it just all suggests new things to measure. It's very self-reinforcing.Eric Topol (30:50):Now, a couple of people who you know well have made some pretty big statements about this whole era of digital biology and I think the virtual cell is perhaps the biggest initiative of all the digital biology ongoing efforts, but Jensen Huang wrote, “for the first time in human history, biology has the opportunity to be engineering, not science.” And Demis Hassabis wrote or said, ‘we're seeing engineering science, you have to build the artifact of interest first, and then once you have it, you can use the scientific method to reduce it down and understand its components.' Well here there's a lot to do to understand its components and if we can do that, for example, right now as both of AI drug discoveries and high gear and there's umpteen numbers of companies working on it, but it doesn't account for the cell. I mean it basically is protein, protein ligand interactions. What if we had drug discovery that was cell based? Could you comment about that? Because that doesn't even exist right now.Steve Quake (32:02):Yeah, I mean I can say something first, Charlotte, if you've got thoughts, I'm curious to hear them. So I do think AI approaches are going to be very useful designing molecules. And so, from the perspective of designing new therapeutics, whether they're small molecules or antibodies, yeah, I mean there's a ton of investment in that area that is a near term fruit, perfect thing for venture people to invest in and there's opportunity there. There's been enough proof of principle. However, I do agree with you that if you want to really understand what happens when you drug a target, you're going to want to have some model of the cell and maybe not just the cell, but all the different cell types of the body to understand where toxicity will come from if you have on-target toxicity and whether you get efficacy on the thing you're trying to do.Steve Quake (32:55):And so, we really hope that people will use the virtual cell models we're going to build as part of the drug discovery development process, I agree with you in a little of a blind spot and we think if we make something useful, people will be using it. The other thing I'll say on that point is I'm very enthusiastic about the future of cellular therapies and one of our big bets at CZI has been starting the New York Biohub, which is aimed at really being very ambitious about establishing the engineering and scientific foundations of how to engineer completely, radically more powerful cellular therapies. And the virtual cell is going to help them do that, right? It's going to be essential for them to achieve that mission.Eric Topol (33:39):I think you're pointing out one of the most important things going on in medicine today is how we didn't anticipate that live cell therapy, engineered cells and ideally off the shelf or in vivo, not just having to take them out and work on them outside the body, is a revolution ongoing, and it's not just in cancer, it's in autoimmune diseases and many others. So it's part of the virtual cell need. We need this. One of the things that's a misnomer, I want you both to comment on, we keep talking about single cell, single cell. And there's a paper spatial multi-omics this week, five different single cell scales all integrated. It's great, but we don't get to single cell. We're basically looking at 50 cells, 100 cells. We're not doing single cell because we're not going deep enough. Is that just a matter of time when we actually are doing, and of course the more we do get down to the single or a few cells, the more insights we're going to get. Would you comment about that? Because we have all this literature on single cell comes out every day, but we're not really there yet.Steve Quake (34:53):Charlotte, do you want to take a first pass at that and then I can say something?Charlotte Bunne (34:56):Yes. So it depends. So I think if we look at certain spatial proteomics, we still have subcellular resolutions. So of course, we always measure many different cells, but we are able to somewhat get down to resolution where we can look at certain colocalization of proteins. This also goes back to the point just made before having this very good environment to study drugs. If I want to build a new drug, if I want to build a new protein, the idea of building this multiscale model allows us to actually simulate different, somehow binding changes and binding because we simulate the effect of a drug. Ultimately, the redouts we have they are subcellular. So of course, we often in the spatial biology, we often have a bit like methods that are rather coarse they have a spot that averages over certain some cells like hundreds of cells or few cells.Charlotte Bunne (35:50):But I think we also have more and more technologies that are zooming in that are subcellular where we can actually tag or have those probe-based methods that allow us to zoom in. There's microscopy of individual cells to really capture them in 3D. They are of course not very high throughput yet, but it gives us also an idea of the morphology and how ultimately morphology determine certain somehow cellular properties or cellular phenotype. So I think there's lots of progress also on the experimental and that ultimately will back feed into the AI virtual cell, those models that will be fed by those data. Similarly, looking at dynamics, right, looking at live imaging of individual cells of their morphological changes. Also, this ultimately is data that we'll need to get a better understanding of disease mechanisms, cellular phenotypes functions, perturbation responses.Eric Topol (36:47):Right. Yes, Steve, you can comment on that and the amazing progress that we have made with space and time, spatial temporal resolution, spatial omics over these years, but that we still could go deeper in terms of getting to individual cells, right?Steve Quake (37:06):So, what can we do with a single cell? I'd say we are very mature in our ability to amplify and sequence the genome of a single cell, amplify and sequence the transcriptome of a single cell. You can ask is one cell enough to make a biological conclusion? And maybe I think what you're referring to is people want to see replicates and so you can ask how many cells do you need to see to have confidence in any given biological conclusion, which is a reasonable thing. It's a statistical question in good science. I think I've been very impressed with how the mass spec people have been doing recently. I think they've finally cracked the ability to look at proteins from single cells and they can look at a couple thousand proteins. That was I think one of these Nature method of the year things at the end of last year and deep visual proteomics.Eric Topol (37:59):Deep visual proteomics, yes.Steve Quake (38:00):Yeah, they are over the hump. Yeah, they are over the hump with single cell measurements. Part of what's missing right now I think is the ability to reliably do all of that on the same cell. So this is what Charlotte was referring to be able to do sort of multi-modal measurements on single cells. That's kind of in its infancy and there's a few examples, but there's a lot more work to be done on that. And I think also the fact that these measurements are all destructive right now, and so you're losing the ability to look how the cells evolve over time. You've got to say this time point, I'm going to dissect this thing and look at a state and I don't get to see what happens further down the road. So that's another future I think measurement challenge to be addressed.Eric Topol (38:42):And I think I'm just trying to identify some of the multitude of challenges in this extraordinarily bold initiative because there are no shortage and that's good about it. It is given people lots of work to do to overcome, override some of these challenges. Now before we wrap up, besides the fact that you point out that all the work has to be done and be validated in real experiments, not just live in a virtual AI world, but you also comment about the safety and ethics of this work and assuming you're going to gradually get there and be successful. So could either or both of you comment about that because it's very thoughtful that you're thinking already about that.Steve Quake (41:10):As scientists and members of the larger community, we want to be careful and ensure that we're interacting with people who said policy in a way that ensures that these tools are being used to advance the cause of science and not do things that are detrimental to human health and are used in a way that respects patient privacy. And so, the ethics around how you use all this with respect to individuals is going to be important to be thoughtful about from the beginning. And I also think there's an ethical question around what it means to be publishing papers and you don't want people to be forging papers using data from the virtual cell without being clear about where that came from and pretending that it was a real experiment. So there's issues around those sorts of ethics as well that need to be considered.Eric Topol (42:07):And of those 40 some authors, do you around the world, do you have the sense that you all work together to achieve this goal? Is there kind of a global bonding here that's going to collaborate?Steve Quake (42:23):I think this effort is going to go way beyond those 40 authors. It's going to include a much larger set of people and I'm really excited to see that evolve with time.Eric Topol (42:31):Yeah, no, it's really quite extraordinary how you kick this thing off and the paper is the blueprint for something that we are all going to anticipate that could change a lot of science and medicine. I mean we saw, as you mentioned, Steve, how that deep visual proteomics (DVP) saved lives. It was what I wrote a spatial medicine, no longer spatial biology. And so, the way that this can change the future of medicine, I think a lot of people just have to have a little bit of imagination that once we get there with this AIVC, that there's a lot in store that's really quite exciting. Well, I think this has been an invigorating review of that paper and some of the issues surrounding it. I couldn't be more enthusiastic for your success and ultimately where this could take us. Did I miss anything during the discussion that we should touch on before we wrap up?Steve Quake (43:31):Not from my perspective. It was a pleasure as always Eric, and a fun discussion.Charlotte Bunne (43:38):Thanks so much.Eric Topol (43:39):Well thank you both and all the co-authors of this paper. We're going to be following this with the great interest, and I think for most people listening, they may not know that this is in store for the future. Someday we will get there. I think one of the things to point out right now is the models we have today that large language models based on transformer architecture, they're going to continue to evolve. We're already seeing so much in inference and ability for reasoning to be exploited and not asking for prompts with immediate answers, but waiting for days to get back. A lot more work from a lot more computing resources. But we're going to get models in the future to fold this together. I think that's one of the things that you've touched on the paper so that whatever we have today in concert with what you've laid out, AI is just going to keep getting better.Eric Topol (44:39):The biology that these foundation models are going to get broader and more compelling as to their use cases. So that's why I believe in this. I don't see this as a static situation right now. I just think that you're anticipating the future, and we will have better models to be able to integrate this massive amount of what some people would consider disparate data sources. So thank you both and all your colleagues for writing this paper. I don't know how you got the 42 authors to agree to it all, which is great, and it's just a beginning of something that's a new frontier. So thanks very much.Steve Quake (45:19):Thank you, Eric.**********************************************Thanks for listening, watching or reading Ground Truths. Your subscription is greatly appreciated.If you found this podcast interesting please share it!That makes the work involved in putting these together especially worthwhile.All content on Ground Truths—newsletters, analyses, and podcasts—is free, open-access, with no ads..Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. And such support is becoming more vital In light of current changes of funding by US biomedical research at NIH and other governmental agencies.Thanks to my producer Jessica Nguyen and to Sinjun Balabanoff for audio and video support at Scripps Research. Get full access to Ground Truths at erictopol.substack.com/subscribe

Die frühen Mönche klebten sich Kerzenstummel auf den Daumennagel, wenn sie nachts in einer dunklen Kirche ihre Gebete lasen. Urs von Wulfen bedenkt Redewendungen christlichen Ursprungs.

Die frühen Mönche klebten sich Kerzenstummel auf den Daumennagel, wenn sie nachts in einer dunklen Kirche ihre Gebete lasen. Urs von Wulfen bedenkt Redewendungen christlichen Ursprungs.

In der Diskussion um die Hintergründe des russischen Angriffskriegs gegen die Ukraine beziehen sich viele Stimmen in Politik und Publizistik auf Willy Brandts Ostpolitik – aus teils ganz unterschiedlichen Motiven und mit verschiedenen Stoßrichtungen. Einige sehen in ihr die Ursünde, aus der alle folgenden Irrtümer der deutschen Russlandpolitik abzuleiten seien – von der Abhängigkeit von russischen Energielieferungen bis zum Appeasement gegenüber Putin. Andere wiederum wollen in ihr konkrete Handlungsanweisungen für den Friedensschluss erkennen. Gestritten wird auch darüber, ob die Politik des „Wandels durch Annäherung“ (Egon Bahr) die deutsche Einheit und die europäische Osterweiterung ermöglicht oder die Existenz der kommunistischen Diktaturen vielmehr verlängert habe. Worin die Ziele, Inhalte und Methoden von Brandts Neuer Ostpolitik tatsächlich bestanden, darüber herrscht jedoch verbreitete Unkenntnis. Der Historiker Dr. Bernd Rother blickt zurück auf die Ursprünge und Ergebnisse jener Ostpolitik und fragt auch danach, inwieweit sie als Blaupause für den Weg zu einem Ende des Krieges und für eine friedliche Zukunft für die Ukraine dienen kann. Im Anschluss an seinen Vortrag diskutiert Bernd Rother mit dem Publizisten Albrecht von Lucke.

Send us a textWhy have nightmares when you can have daymares? Visions of untold horrors awaiting you at every turn, wouldn't that be something? Urs, TEX, and Zo all think so!Urs Rex played by Steph of @EquinoxDiceVenia Venus played by Kayla of @acourtofkaylaElliana Zelerian “Eli” played by Hannah of @HannahmarieartworkTX-009 “Tex” and Phyll played by Scott of @the_gray_area_ Zolada “Zo” played by Lydia of @LydiakorynRenova played by Anna of @MistyMoutnainLegendsEveryone else played by Luke of @MistyMountainLegendsSupport the Podcast: https://ko-fi.com/mistymountainlegendsMusic by Amaksi on Pixabay, Jimmy Svensson, Kyle Preston, SEA and Alon Peretz on ArtlistLogo by Red Queen HailsSupport the show

David Druid och Linnea Wikblad går så få steg som möjligt, allt om Super Bowl och Kaliffa vill ha egen serie! Lyssna på alla avsnitt i Sveriges Radio Play. Hela veckans Morgonpasset i P3 hör du i Sveriges Radio Play.Allvarligt: David Druid orkar inte med gymboys. Linnea Wikblad berättar allt om nykterhetsrörelsen! Så få steg går du! Ursäkta röran, vi flyttar runt! Nattens Super Bowl: Vår hiphopexpert Petter Hallén går genom Kendrick Lamars halftime show. Philip Minja pratar om resten av Super Bowl! Kaliffa om helgens Mellouppträdande, husbygge i Gambia och mycket om hans lingo! Matilda Rånge på P3 Nyheter rapporterar om statsministers tal till nationen efter skolskjutningen i Örebro och Emily in Paris kritiserade surrogatmödraskap. Obekvämt falskt hål idag om: Förstå filmreferenser!Tidpunkter i avsnittet:14:41 Nyhetsfördjupning: Statsministerns tal till nationen.18:42 Super Bowl: Så var Kendrick Lamars halftime show.49:48 Nyhetsfördjupning: Emily in Paris irl-surrogatmödraskap.55:39 Super Bowl: Så var matchen.1:09:50 Matilda Rånges obekväma falska lilla hål: Austin Powers-referenser.1:21:01 Kaliffa.Kapitellänkarna ovan leder till avsnittet utan musik i Sveriges Radio Play.Programledare: David Druid och Linnea Wikblad.

Send us a textTo the library! We see heartfelt conversations between Urs and Eli and also get to learn some new information about the Zeroes and the destruction of Florf! And... our first F-bomb!Urs Rex played by Steph of @EquinoxDiceVenia Venus played by Kayla of @acourtofkaylaElliana Zelerian “Eli” played by Hannah of @HannahmarieartworkTX-009 “Tex” and Phyll played by Scott of @the_gray_area_ Zolada “Zo” played by Lydia of @LydiakorynRenova played by Anna of @MistyMoutnainLegendsEveryone else played by Luke of @MistyMountainLegendsSupport the Podcast: https://ko-fi.com/mistymountainlegendsMusic by Amaksi on Pixabay, Flint and Michael Vignola on ArtlistLogo by Red Queen HailsSupport the show

Violonistul Hector și câinele lui, Hugo, sunt cei mai buni prieteni. Când Hector se pensionează, Hugo învață să cânte chiar el la vioară. Curând, Urs, pianist celebru în întreaga lume, îi oferă ocazia să călătorească pe tot globul pământesc și să cânte în fața a mii de oameni – o șansă la care Hector visase dintotdeauna. Oare poate învăța Hector să-și lase deoparte mândria si să se bucure pentru Hugo, înainte să fie prea târziu?

Im ältesten «Bären» der Schweiz in Trubschachen BE wird Volksmusik gross geschrieben. «Potzmusig» bringt Top-Acts wie den Jodlerklub Trub, Chummlig und die Äntlibucher Giele auf die Bühne. Dazu: exklusive Einblicke in den Berner Bärenpark – tierisch gute Unterhaltung garantiert. Im bernischen Trubschachen steht der älteste «Bären» der Schweiz – ein Restaurant mit reicher Geschichte. Bereits 1356 wurde es erstmals erwähnt, brannte im 17. Jahrhundert vollständig ab und wurde danach wiederaufgebaut. Seit über 30 Jahren wird es von Urs Mäder geführt. Regelmässig erklingt in der traditionsreichen Gaststube Volksmusik. Das ehrwürdige Gebäude im typischen Berner Stil steht im Dorfkern von Trubschachen. Über dem Eingang thront ein riesiger Bär, der die Gäste zum Verweilen einlädt. Die Küche des Wirtes Urs Mäder serviert herzhafte Menüs – perfekt für Gäste mit «Bärenhunger». Dass der Wirt ebenfalls Urs heisst (vom lateinischen «ursus» für «Bär»), scheint kein Zufall zu sein. Hier passt einfach alles – ideal für eine bärenstarke «Potzmusig»-Sendung. Die musikalischen Highlights der Sendung spiegeln die reiche Volksmusiktradition der Region wider. Der Jodlerklub Trub, gegründet 1968, entstand, nachdem auch umliegende Gemeinden eigene Jodlerklubs ins Leben gerufen hatten. Bereits drei Wochen nach der ersten Informationsveranstaltung fand die Gründungsversammlung statt. In der Sendung präsentiert der Jodlerklub ein Lied des Berner Komponisten Ueli Moor, das vor der malerischen Kulisse der Emmentaler Höhen mit Blick auf Eiger, Mönch und Jungfrau gesungen wird . Eine Premiere feiert die junge Formation Chummlig, die 2022 von Urs Liechti und Simona Spichiger gegründet wurde. Ihr Stil verbindet den klassischen Berner Ländler mit Einflüssen aus irischer, schwedischer und deutscher Musik. Mit fast vier Jahrzehnten Bühnenerfahrung begeistern die Äntlibucher Giele ihr Publikum. Ihr Markenzeichen sind die zahlreichen Eigenkompositionen, die besonders beim treuen Fanclub grossen Anklang finden. Ihr lebhaftes Schwyzerörgeli-Spiel sorgt immer wieder für ausgelassene Stimmung. Aus Wiggen LU tritt die Familie Gerber auf. Mit einem urchigen, bodenständigen Stil spielen Vater Ruedi Gerber und seine drei Söhne ein einzigartiges Repertoire. Besonders hervorzuheben ist der älteste Sohn Daniel, der die Schwyzerörgeli nicht wie üblich mit einer Bassgeige, sondern mit einer Tuba begleitet – eine ungewöhnliche und klanglich interessante Kombination. Daniel Gerber tritt ausserdem gemeinsam mit Kollegen aus der Guggenmusig auf. Zusammen bringen sie einen Hit aus der Oberkrainer-Szene auf die Bühne: «Auf der Autobahn» von Slavko Avsenik. Ein weiteres musikalisches Highlight bietet das Dani Bösch Trio aus Appenzell. Mit Dani Bösch am Akkordeon, Urs Kryenbühl am Klavier und Oscar Della Dorr am Kontrabass interpretiert das Trio gepflegte Akkordeonmusik. Zum Abschluss spielen sie zusammen mit Nicolas Senn am Hackbrett den passenden Titel «Bäre-Schottisch». Einblicke in den Berner Bärenpark Kurz vor der Winterruhe im Oktober besuchte Moderator Nicolas Senn den Bärenpark in Bern. Dort gab Tierpfleger Roland Thomi spannende Einblicke in die Arbeit mit den Bären. Nicolas durfte sogar selbst Hand anlegen und den Pfleger bei seinen Aufgaben unterstützen.

Send us a textWill Eli and Venia FINALLY have that conversation? Probably not but we can hope! Urs meets with Professor PB and Renova explains espresso to TEX and Zo.Urs Rex played by Steph of @EquinoxDiceVenia Venus played by Kayla of @acourtofkaylaElliana Zelerian “Eli” played by Hannah of @HannahmarieartworkTX-009 “Tex” and Phyll played by Scott of @the_gray_area_ Zolada “Zo” played by Lydia of @LydiakorynRenova played by Anna of @MistyMoutnainLegendsEveryone else played by Luke of @MistyMountainLegendsSupport the Podcast: https://ko-fi.com/mistymountainlegendsMusic by Amaksi on Pixabay, Adrien De La Salle, Shahead Mostafafar, and Onyx Music on ArtlistLogo by Red Queen HailsSupport the show

Connect with Abdullah: https://www.linkedin.com/in/zaitera https://zaitech.dev Connect with Urs: https://www.linkedin.com/in/urs-peter-70a2882 Full episode on YouTube ▶️ https://youtu.be/hwTlKa1_CoE Beyond Coding Podcast with ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

In this thought-provoking episode of Mindset Mastery Moments, Dr. Alisa Whyte sits down with Urs Koenig, veteran executive coach, former UN peacekeeper, ultra-endurance athlete, and founder of the Radical Humility Leadership Institute. Together, they explore the transformative power of humility in leadership and why it is essential for today's complex and dynamic world.Urs shares powerful insights from his groundbreaking book, Radical Humility: Be a Badass Leader and a Good Human, including the five key shifts leaders must make to embrace a humble leadership model. Drawing from his experiences in NATO peacekeeping missions, corporate coaching for Fortune 500 companies, and ultra-endurance sports, Urs provides actionable strategies for leaders to elevate their teams, foster collaboration, and build meaningful relationships.In this engaging conversation, Urs and Dr. Alisa discuss:The importance of understanding team members' ambitions and helping them achieve their goals.How vulnerability and humility strengthen relationships and lead to collective wins.Why humility is not a weakness but a strength that complements confidence, ambition, and decisiveness.Leadership lessons from Urs's time as an ultra-endurance athlete and UN peacekeeper.The mindset shift from the outdated heroic paradigm to a more human-centered approach to leadership.This episode is packed with practical takeaways for leaders across all domains—whether you're leading a company, a team, or your own family. Don't miss this inspiring conversation with Urs Koenig, a leader who is redefining what it means to lead with humility.Connect with Urs Koenig:Website: www.urskoenig.comBook: Send us a textWorld of Work Experts on the People and Performance PodcastInterviews with experts and business leaders focused on ways to inspire employees. Everyday AI: Your daily guide to grown with Generative AICan't keep up with AI? We've got you. Everyday AI helps you keep up and get ahead.Listen on: Apple Podcasts SpotifySupport the showMindset Mastery Moments Podcast with Dr. Alisa WhyteThank you for tuning in to the Mindset Mastery Moments Podcast, hosted by Dr. Alisa Whyte, a global empowerment leader, the #1 mindset disruptor, and international best selling bestselling author. Dr. Alisa empowers individuals to break through barriers and master their mindset for success in life and business.

Emily Sander talks with Urs Koenig about his book, "Radical Humility: Be a Badass Leader and a Good Human." They discuss his experiences, including how tough feedback can piss people off but still foster growth. Urs shares leadership tips like "eyes on, hands off," referencing US Women's Soccer Team Captain Carla Overbeck's style, and a new twist on feedback called "feedforward." He mentions that one of the most powerful things a leader can say is, "I screwed that up." They also touch on training for hostage situations, and the value of meaningful connections for Chiefs of Staff.Links Mentioned:Urs Koenig's WebsiteUrs Koenig's Book: Radical HumilityClarity Call with EmilyFree Resources:Strategic Planning Checklist Chief of Staff Skills Assessment ChecklistA Day in the Life of a Chief of StaffChief of Staff ToolkitGet in touch with Emily:Connect on LinkedInFollow on YouTubeLearn more about coaching Sign up for the newsletterClarity Call with EmilyWho Am I?If we haven't yet before - Hi

Want to know what it means to be a UN Peacekeeper? How do humility and being a great leader go together? What's the difference between heroic and humble leadership? To help answer these questions, we have Urs Koenig joining us today on The Balancing Act Podcast. Urs is an internationally renowned keynote speaker, bestselling author, and leading expert on humble leadership. He is a former UN military peacekeeper and a NATO military peacekeeping commander. He's the author of Radical Humility: Be a Badass Leader and a Good Human. Tune into episode 171 to hear Urs' story, his career "rocket-booster" moment, and his perspectives on heroic versus humble leadership. Learn more about Urs Koenig at: https://www.urskoenig.com/  Learn more about Andrew Temte at: www.andrewtemte.com   #humbleleadership #radicalhumility #unpeacekeeper #employeeengagement 

Send us a textNote: After publishing, we noticed an error in the audio file for this episode that caused Scott's audio (Tex and Phyll) to overlap with others. Unfortunately, we are traveling for the next week without access to our editing software. We will correct the error ASAP, and we hope you will still enjoy the episode!Welcome back to Trip-U! A thriving university and home to the cash crew. We find the crew entering into their second year of university after surviving a harrowing first year. Urs and Eli work out together, Venia changes her name, Tex and Phyll start a band, and Zo makes some merch!Urs Rex played by Steph of @EquinoxDiceVenia Venus played by Kayla of @acourtofkaylaElliana Zelerian “Eli” played by Hannah of @HannahmarieartworkTX-009 “Tex” and Phyll played by Scott of @the_gray_area_ Zolada “Zo” played by Lydia of @Lydiakoryn(?) played by Anna of @MistyMoutnainLegendsEveryone else played by Luke of @MistyMountainLegendsSupport the Podcast: https://ko-fi.com/mistymountainlegendsMusic by Amaksi on Pixabay, Temuz Dekel, Roie Shpigler, and Borrtex on ArtlistLogo by Red Queen HailsSupport the show

Do you think mastering your leadership path means always having the answers? What if embracing humility could make you a more effective and respected leader? In a world where leadership demands more empathy, adaptability, and connection than ever before, this episode dives into how you can lead with confidence while staying human. Learn how to shift from a traditional, bottleneck leadership style to one that inspires trust, builds resilience, and drives high performance. Here's what you'll gain from tuning in: Practical strategies for shifting from a "heroic" to a "humble" leadership model. Insights into building psychological safety and trust within your team. Techniques for leading with clarity and empowering others without micromanaging. Don't miss this episode—unlock your full leadership potential and learn how to lead with radical humility. Hit play now to start transforming your leadership style! Check Out: [04:24] Heroic vs. Humble Leadership [08:02] Five Shifts to Transform Your Leadership [27:25] Lessons from Ultra-Endurance Connect with Urs: https://www.linkedin.com/in/urs-koenig-ab3828/ urskoenig.com Leadership Without Using Your Soul podcast offers insightful discussions on leadership and management, focusing on essential communication skills, productivity, teamwork, delegation, and feedback to help leaders navigate various leadership styles, management styles, conflict resolution, time management, and active listening while addressing challenges like overwhelm, burnout, work-life balance, and problem-solving in both online and in-person teams, all aimed at cultivating human-centered leadership qualities that promote growth and success. Learn more about your ad choices. Visit megaphone.fm/adchoices

"Leadership is about being tough on results but tender on people. You need to find that balance between achieving goals and caring for your team."In this episode of the Business is Human podcast, host Rebecca Fleetwood Hession welcomes Urs Koenig, Executive Coach, Military Peacekeeper, and Author of Radical Humility: Be a Badass Leader and a Good Human. Together, they unpack why humility is a crucial asset for today's leaders, breaking down how trust and connection impact long-term success in leadership. Urs also explains his journey from military command to executive coaching, sharing how his unique experiences reveal that humble leadership is anything but weak—it's a strategy for achieving both meaningful relationships and impactful results.In this episode, you'll learn:How humble leadership can improve performance and team alignmentWays to balance business goals with human connection for sustainable successWhy showing vulnerability as a leader can lead to deeper trust and cooperationThings to listen for:(00:00) Intro(01:46) The concept of radical humility(02:11) Urs's background and experiences in humble leadership(04:13) The journey to writing ‘Radical Humility'(06:50) How human connection and nurture play into leadership(15:46) Tough on results, tender on people(19:46) Building trust through vulnerability and connection(27:19) Balance discomfort with self-care for growth(29:51) Turning your inner critic into a first responderConnect with Urs:Website: https://www.urskoenig.com/LinkedIn: https://www.linkedin.com/in/urs-koenig-ab3828/Instagram: https://www.instagram.com/koenigurs/Facebook: https://www.facebook.com/urs.koenig.7X: https://twitter.com/urskoenigConnect with Rebecca:https://www.rebeccafleetwoodhession.com/

In today's episode we talked with former UN and NATO peacekeeper, professor, and bestselling author Oars COnig about why humble leadership is the key to winning in today's world. In this episode and his new book, Radical Humility: Be a Badass Leader AND a Good Human, Urs challenges the common misconception that humility equals weakness and presents the idea that winning in today's world requires a new kind of humble leadership. We explore the three core pillars of this leadership style: Deep self-awareness Focus on collaborative relationships Growth mindset Additionally, we break down the shift from "THEN" leadership, which organizations are used to, to "NOW" leadership, which embraces radical humility. This shift is explained through five key transformations: Dig Deep – Know yourself, focus like an elite athlete, and fail successfully. Tough on Results, Tender on People – Care deeply about others while maintaining high standards. Lead like a Compass – Prioritize clarity over control and create a leadership development culture. Full Transparency – Be honest about your weaknesses and share the truth. Champion a Fearless Culture – Build teams that challenge norms because "Everything you want is on the other side of fear" (Jack Canfield). Tune in to learn how you can embrace radical humility to become a badass leader and a good human! To connect with Urs, be sure to visit his website or follow him on social media. Website: https://www.urskoenig.com Linkedin: https://www.linkedin.com/in/urs-koenig-ab3828/ Instagram: https://www.instagram.com/koenigurs/ Buy His Book on Amazon: Radical Humility: Be a Badass Leader AND a Good Human *** I'm excited to share that I'm now a member of the Maxwell Leadership Certified Team! This means I can bring you the teachings of John C. Maxwell—yep, the country's No. 1 leadership authority. This certification isn't just about me leveling up, it's about showing you that I'm committed to delivering the very best guidance for you and your team. If you're ready to transform your leadership, go to leadershipontherocks.com and click the 'Schedule a Call' button. Whether it's personal development, company-wide training, or change management—let's connect and start your journey to success together. Let's thrive together! CONTACT US: Visit our website at https://www.leadershipontherocks.com/ Follow us online at: Facebook: Leadership on the Rocks Instagram: @leadershipontherocks Linked In: Bethany Rees Twitter: @Leadontherocks Email us at contact@bressentialservices.com

Check Urs Koenig's Speaking Availability: https://premierespeakers.com/speakers/urs-koenig In this episode of the Beyond Speaking podcast, Urs Koenig shares his journey from growing up in Switzerland to becoming a leadership expert, ultra-endurance athlete, UN peacekeeper, and professor. He delves into his philosophy of “radical humility,” which emphasizes deep self-awareness, relational leadership, and creating psychologically safe cultures. Urs shares insights from his experience in the military and ultra-endurance sports, showing how humility and resilience lead to success in leadership and life. The discussion also touches on tough love in leadership, learning from failure, and Urs' purpose-driven mission to give back through his speaking business and work with Junior Achievement.

IN EPISODE 197: Humble leaders don't see themselves as better than others - they try to make others better. In Episode 197, former NATO commander Urs Koenig explores the beliefs and behaviors of radical humility and why humble leaders stand out with their approach. We cover lots of ground here, including how to lead relationally and focus on strategy, not tactics; how to build a leadership factory where we train people to leave us; and how to get honest feedback from others without creating fear or friction. Humble leaders are less involved but more relevant - and after listening to Urs, you'll be ready to start practicing radical humility as well. ABOUT URS KOENIG: Urs Koenig is a former United Nations military peacekeeper and NATO military peacekeeping commander, a highly accomplished ultra-endurance champion, a widely published professor, bestselling author, and a seasoned executive coach and keynote speaker. He's the author of Radical Humility: Be a Badass Leader and Good Human.

What do dropbars on mountain bikes, our love for electric tyre inflators, and a random chirping noise have in common? Very little, but it's all covered in this week's jam-packed Geek Warning!Join Dave and Brad as they discuss emerging trends in gravel bikes, which are increasingly getting rowdy. The recent Leadville race and the new BMC URS both offer discussion points for this.This week, Dave is thinking about battery-powered tyre inflators, which will be covered in this week's edition of Threaded. The geeks then discuss their favourite bartapes and why they like them.You'll then hear three member questions answered in the recently returned “Ask a Wrench” segment. From chain lube for Cross to solving a mystery chirping noise, and the geek's most embarrassing/costly mistakes.Finally the episode wraps up with a few new tech bites from around the cycling industry. There are new shorter-length ShockStop suspension stems from Redshift. Forge+Bond brings its theromplastic technology to a handlebar. There are more bad e-bikes from the automotive world. And a heads-up of two custom bike shows coming this month.Enjoy!Time stamps:4:45 - Leadville showing bike trends or just one-offs for a specific event?15:48 - BMC has updated its URS gravel bike23:05 - Electric tyre inflators are all the buzz28:50 - Pick One: Bartapes34:25 - Ask a Wrench1:02:40 - Ford's new bad e-bikes1:06:05 - Forge+Bond has a handlebar1:09:05 - Redshift adds 55 and 70 mm versions of the ShockStop stem1:12:20 - MADE is nearly here

When veteran executive coach, professor, and ultra-endurance champion Urs Koenig signed up to be a NATO peacekeeping commander and United Nations peacekeeper in his fifties, he thought he knew a thing or two about leadership.In his new book Radical Humility he openly shares that what he discovered as he embarked on this journey was a new leadership paradigm. One that replaces the top-down, “heroic” leadership of the past,With a more human-centered approach that views humility as a strength and key to achieving goals in today's complex world.Today we will take a deep dive into the topic of humility as we explore:Urs stories of facing various challenges, including struggling with academics and getting kicked out of school, and how these moments helped shape his professional trajectory.Why humility is a strength, but not a replacement for competenceAn athletic dream of completinga race across America. How it unraveled, and what Urs learned from failure that helped him find the resilience to come back stronger.How to stay open and receptive to learning when it's hard. Including when we: Receive tough feedback, When we fail, And when we experience difficult emotions. Reflections on the intersection of backbone and heart in leadership and how leaders can get better at being tough on results but tender on people. The importance of building thriving relationships and practices that support doing so at work and in our lives.If you find this conversation intriguing I  would encourage you to check out Radical Humility: Be a Badass Leader and a Good Human, which you can find wherever books are sold. More about Urs:Urs Koenig is a former United Nations military peacekeeper and NATO military peacekeeping commander, a highly accomplished ultraendurance champion, a widely published professor, bestselling author of Radical Humility, and a seasoned executive coach and keynote speaker with more than three decades of experience helping hundreds of leaders and dozens of executive teams unlock new levels of achievement across four continents. He is the founder of the Radical Humility Leadership Institute and speaks frequently on the topic of leadership to corporations and associations across the globe. His message of Radical Humility in leadership has inspired teams from across the spectrum, including Amazon, Starbucks, the Society of Human Resource Management, Vistage, the University of Melbourne, and Microsoft. He holds a PhD in geography and a Master of Science from the University of Zürich, Switzerland, and an MBA from the Australian Graduate School of Management.  For more, please visit urskoenig.comDid you find this episode inspiring? Here are other conversations we think you'll loveMeeting Failure with Curiosity and Compassion | Amy EdmondsonThe Transformative Power of Humility | Dr. Daryl Van TongerenMeeting Challenges with Backbone and Heart | Roshi Joan Halifax and Rhonda MageeEnjoying the show? Please rate it wherever you listen to your podcasts. Thanks for listening!Support the Show.

As a manager, you are entrusted to lead and manage your team, but that doesn't mean you'll always get things right.When you have power and authority, it can be challenging to own your shortfalls and mistakes. After all, you are someone that your team members look up to. But our guest thinks otherwise.He believes that showing up with radical humility builds trust, fosters connection, and creates a psychologically safe environment. So, how do you practice humility as a leader?Today's guest is Urs Koenig, a former United Nations military peacekeeper and NATO military peacekeeping commander. He is a highly accomplished ultra-endurance champion, a widely published professor, and a seasoned executive coach and keynote speaker with more than three decades of experience helping hundreds of leaders and dozens of executive teams unlock new levels of achievement across four continents. He is the founder of the Radical Humility Leadership Institute and speaks frequently on the topic of leadership to corporations and associations across the globe. Urs and I talk about the importance of humility in leadership, emphasizing self-awareness, relational leadership, and a growth mindset.He also explains the need for modern leadership to depart from the traditional command-and-control model in favor of one that empowers team members and builds trust. Plus, in the extended episode available to Podcast+members, Urs breaks down the five mental shifts that every leader must make and how to lead like a compass.Join the conversation now!Get FREE mini-episode guides with the big idea from the week's episode delivered to your inbox when you subscribe to my weekly email.Conversation Topics(00:00) Intro(02:03) What is radical humility, and why is it important?(04:35) Leadership practices that were working before but not anymore(06:55) How to encourage honest feedback from your team(09:05) Mastering self-awareness to become a better leader(12:27) The Ted Lasso technique explained(18:38) The quickest way to build trust with your team(23:17) The importance of building psychological safety and nurturing a fearless culture(27:34) A great manager Urs has worked for(28:44) Keep up with Urs(29:05) [Extended Episode Only] 5 mental shifts that every leader must make(29:58) [Extended Episode Only] How to lead like a compass(37:12) [Extended Episode Only] A great example of when leaders lead with radical humilityAdditional Resources:- Get the extended episode by Joining The Modern Manager Podcast+ Community for just $15 per month- Read the full transcript here- Follow me on Instagram here - Visit my website for more here- Build your team's skills here- Subscribe to my YouTube Channel hereKeep up with Urs Koenig- Grab a copy of Urs book here- Follow Urs on LinkedIn here- Check his website for more information hereFREE  Radical Humility NOW Leadership PromptsUrs is providing members of Podcast+ a PDF of the Radical Humility NOW Leadership NOW Prompts. These are exercises from the book that can help you apply Radical Humility in your leadership and life. To get this bonus and many other member benefits, become a member of The Modern Manager Podcast+ Community.---------------------The Modern Manager is a leadership podcast for rockstar managers who want to create a working environment where people thrive, and great work gets done.Follow The Modern Manager on your favorite podcast platform so you won't miss

Urs Koenig is a veteran executive coach, professor, ultra-endurance champion, former UN Peacekeeper, author, and keynote speaker. All these seemingly disparate paths led him to one idea: that the best leaders lead from a place of humility. Urs has captured those ideas in his new book, Radical Humility: Be a Badass Leader and a Good Human. His lessons come from Big Events like having to pull out of the Race Across America because of a life-threatening condition and watching children in Kosovo enact brutalities they continue to witness in their region. They also come from Small Things like being told off by dad for not preparing properly for a camping trip and getting a dressing-down from a junior officer for a careless mistake. Connect wth him at urs@urskoenig.com NEW WOC MASTERMIND AND CERTIFICATION PROGRAM As you may have heard, we decided to cancel our 2024 Way of Champions Conference, which opens up the opportunity for us to begin a year long mastermind and coach certification program in the Way of Champions and CTGP materials. If you want to simply take a deeper dive then ever offered before into your coaching and personal development, or work within your school or club improving coaching or transforming the culture, or you want to hit the road as a speaker and presenter working with teams and youth sports organizations, we will give you the tools and support to do so. We are collecting names who are interested at this moment in learning more, you can do so by clicking here and adding your name and email to the list. PUT IN YOUR BULK BOOK ORDERS FOR OUR BESTSELLING BOOKS! Programs such as UNC soccer and lacrosse, Syracuse lacrosse, Stanford Lacrosse, Middlebury College, Colby College, Rutgers University, and many other champions are using THE CHAMPION TEAMMATE book with their athletes. Schools and clubs are using EVERY MOMENT MATTERS for staff development and book clubs. Are you?  We have been fulfilling numerous bulk orders for some of the top high school and collegiate sports programs in the country, will your team be next? Click here to visit John's author page on Amazon Click here to visit Jerry's author page on Amazon Please email John@ChangingTheGameProject.com if you want discounted pricing on 10 or more books on any of our books. Thanks everyone. This week's podcast is brought to you by our friends at Sprocket Sports.  Sprocket Sports is a new software platform for youth sports clubs.  There are a lot of these systems out there, but Sprocket provides the full enchilada. They give you all the cool front-end stuff to make your club look good– like websites and marketing tools – AND all the back-end transactions and services to run your business better so you can focus on what really matters – your players and your teams. Sprocket is built for those clubs looking to thrive, not just survive, in the competitive world of youth sports clubs.  So if you've been looking for a true business partner – not just another app – check them out today at https://sprocketsports.me/CTG. Become a Podcast Champion! This weeks podcast is also sponsored by our Patreon Podcast Champions. Help Support the Podcast and get FREE access to our most popular online courses, a $300 value. If you love the podcast, we would love for you to become a Podcast Champion, (https://www.patreon.com/wayofchampions) for as little as a cup of coffee per month (OK, its a Venti Mocha), to help us up the ante and provide even better interviews, better sound, and an overall enhanced experience. Plus, as a $10 per month Podcast Super-Champion, you will have access to never before released and bonus material, including: Downloadable transcripts of our best podcasts, so you don't have to crash your car trying to take notes! A code to get free access to our online course called “Coaching Mastery,” usually a $97 course, plus four other courses worth over $100, all yours for free for becoming a patron. Other special bonus opportunities that come up time to time Access to an online community of coaches like you who are dedicated listeners of the podcast, and will be able to answer your questions and share their coaching experiences

Urs Koenig reveals how to level up your leadership through the five shifts of radical humility. — YOU'LL LEARN — 1) Why leaders win more when they're humble 2) Two tricks to getting better quality feedback 3) How to make any tough conversation less intimidating Subscribe or visit AwesomeAtYourJob.com/ep975 for clickable versions of the links below. — ABOUT URS — Urs is a former United Nations military peacekeeper and NATO military peacekeeping commander, a highly accomplished ultraendurance champion, a widely published professor, bestselling author, and a seasoned executive coach and keynote speaker with more than three decades of experience helping hundreds of leaders and dozens of executive teams unlock new levels of achievement across four continents. He is the founder of the Radical Humility Leadership Institute and speaks frequently on the topic of leadership to corporations and associations across the globe. His message of Radical Humility in leadership has inspired teams from across the spectrum, including Amazon, Starbucks, the Society of Human Resource Management, Vistage, the University of Melbourne, and Microsoft. He holds a PhD in geography and a Master of Science from the University of Zürich, Switzerland, and an MBA from the Australian Graduate School of Management. Urs is the loving father of two teenage boys who make commanding soldiers look easy. He lives in Seattle, Washington. • Book: Radical Humility: Be a Badass Leader and a Good Human • LinkedIn: Urs Koenig • Website: UrsKoenig.com — RESOURCES MENTIONED IN THE SHOW — • Book: Endurance: Shackleton's Incredible Voyage (Anniversary Edition) by Alfred Lansing • Book: Team of Teams: New Rules of Engagement for a Complex World by General Stanley McChrystal, Tantum Collins, David Silverman, Chris Fussell • Past episode: 707: Amy Edmondson on How to Build Thriving Teams with Psychological Safety — THANK YOU, SPONSORS! — • Harvard Business Review. Get 10% off your subscription at HBR.org/subscriptions with the promo code AWESOME• Hello Bello. Get 30% off your first customizable bundle with HelloBello.com/awesomeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.