Podcasts about boltz

X11Libre is a fork of xorg, do the developers of xorg not want xorg to continue? This week Steve and Noah give you the details of what can only be described as a weird situation. SELF is coming up this weekend, Steve, Noah and executive producer JT will be there and we hope to see you! -- During The Show -- 00:52 Intro Two ways of traveling Noah's airline story Personal entertainment Ente (https://next.ente.io/) 10:28 Self This year is "retro year" old tech could be loaded anything requiring sign in can't be used retro swap Free admission Free HAM radio test Free HAM cram session Lan Party GPG Signing party HAM Radio Meshtastic 22:22 XLibre Project to continue the Xorg display server Xorg developed over several decades Xorg server client model Wayland comes in less developement in Xorg, more in Wayland Freedesktop.org Lots of merge requests closed People running RHEL just take what comes down the pipe Cool that they are improving not just keeping it alive theregister.com (https://www.theregister.com/2025/06/10/xlibre_new_xorg_fork/?td=rt-3a) Github (https://github.com/X11Libre/xserver) Lunduke YouTube Video (https://www.youtube.com/watch?v=ujJCyXfWpOo) Fedora Project Wiki (https://fedoraproject.org/wiki/Changes/X11Libre) 36:06 News Wire Snapd 2.69 - github.com (https://github.com/canonical/snapd/releases) Sway 1.11 - github.com (https://github.com/swaywm/sway/releases) PeerTube 7.2 - joinpeertube.org (https://joinpeertube.org/news/release-7.2) RockyLinux 9.6 - rockylinux.org (https://rockylinux.org/news/rocky-linux-9-6-ga-release) Linux Mint 20 EOL - news.itsfoss.com (https://news.itsfoss.com/linux-mint-20-eol/) Open Source Supply Chain Attacks - thehackernews.com (https://thehackernews.com/2025/06/malicious-pypi-npm-and-ruby-packages.html) Chaos RAT - scworld.com (https://www.scworld.com/news/open-source-chaos-rat-used-in-recent-attacks-targeting-linux) Kali AI - gbhackers.com (https://gbhackers.com/kali-gpt-revolutionizing/) Dots.llm1 - compterworld.com (https://www.computerworld.com/article/4004272/rednote-joins-chinas-open-source-ai-wave-with-the-launch-of-dots-llm1.html) Boltz-2 - nasdaq.com (https://www.nasdaq.com/articles/mit-and-recursion-unveil-boltz-2-revolutionary-open-source-biomolecular-co-folding-model) ChatGPT Used to Disable SecureBoot - tomshardware.com (https://www.tomshardware.com/tech-industry/artificial-intelligence/chatgpt-used-to-disable-secureboot-in-locked-down-device-modded-bios-reflash-facilitated-fresh-windows-and-linux-installs) 37:25 Warp Terminal Foss Force (https://fossforce.com/2025/06/warp-takes-your-terminal-to-light-speed-and-beyond/) It is closed source Uses AI How does Warp stack up against the new RHEL AI? RHEL AI will probly run on the local machine Where it may make sense What is the target audiance? 43:22 Ereader for Music - Steven Tablets? Convertible laptops? Noah bought the PineTab2 for this purpose Nashville Number System SongbookPro (https://songbook-pro.com/) Tabbed PDF viewer Trying proton 51:07 Run OPNsense - Kevin You can't install anything else on netgate appliances Used Sophos with sata drives -- The Extra Credit Section -- For links to the articles and material referenced in this week's episode check out this week's page from our podcast dashboard! This Episode's Podcast Dashboard (http://podcast.asknoahshow.com/445) Phone Systems for Ask Noah provided by Voxtelesys (http://www.voxtelesys.com/asknoah) Join us in our dedicated chatroom #GeekLab:linuxdelta.com on Matrix (https://element.linuxdelta.com/#/room/#geeklab:linuxdelta.com) -- Stay In Touch -- Find all the resources for this show on the Ask Noah Dashboard Ask Noah Dashboard (http://www.asknoahshow.com) Need more help than a radio show can offer? Altispeed provides commercial IT services and they're excited to offer you a great deal for listening to the Ask Noah Show. Call today and ask about the discount for listeners of the Ask Noah Show! Altispeed Technologies (http://www.altispeed.com/) Contact Noah live [at] asknoahshow.com -- Twitter -- Noah - Kernellinux (https://twitter.com/kernellinux) Ask Noah Show (https://twitter.com/asknoahshow) Altispeed Technologies (https://twitter.com/altispeed)

A gene therapy clinical trial for Danon disease run by Rocket Pharmaceuticals has been suspended following the death of a patient. MIT and Recursion have released Boltz-2, an open-source tool that predicts molecular binding affinity at newfound speed and accuracy, aiming to democratize commercial drug discovery. Intellia Therapeutics saw its stock nosedive late last week after a patient in its Phase III trial of the CRISPR-based therapy experienced non-lethal liver toxicity. In other news, a therapeutic plasma exchange regimen combined with intravenous immunoglobulin reduced some biomarkers of biological age in humans. Sanofi has agreed to acquire Blueprint Medicines for up to $9.5 billion, and a universal CAR T cell therapy was produced by applying CRISPR gene editing to cells donated by healthy individuals. Join GEN editors Corinna Singleman, PhD, Alex Philippidis, Fay Lin, PhD, and Uduak Thomas for a discussion of the latest biotech and biopharma news.  Listed below are links to the GEN stories referenced in this episode of Touching Base Danon Disease Patient Dies in Rocket Gene Therapy Trial By Alex Philippidis, GEN, May 27, 2025 Boltz-2 Released to Democratize AI Molecular Modeling for Drug Discovery By Fay Lin, PhD, GENEdge, June 6, 2025 StockWatch: Intellia Stumbles on News of Patient's Severe Liver Toxicity By Alex Philippidis, GEN, May 30, 2025 The State of CRISPR Summit Registration https://bit.ly/CRISPR25 Plasma Exchange in Humans Reduces Biological Age by Over Two Years GEN, June 1, 2025 Sanofi to Acquire Blueprint Medicines for Up to $9.5B By Alex Philippidis, GEN Edge, June 2, 2025 "Universal" CAR-T Immunotherapy Targets Relapsed/Refractory Blood Cancers GEN, May 30, 2025 Hosted on Acast. See acast.com/privacy for more information.

Send us a textIn an obtuse world Mark & Jefe are here to keep you vertical.This time Boltz N Holez talks about our recent Kalashni-Con experience and shooting competitions in general. FIND BOLTZ ON INSTAGRAM HERE: https://www.instagram.com/boltz_n_holez/THANK YOU TO OUR SPONSOR XS SightsXS Sights - https://xssights.com/20% Discount with code LARPBooks We Recommend:Herbal Medic: https://amzn.to/3ArhUGXTriphasic Tactical Training Manual: https://a.co/d/0I1iYRuThe Merck Manual of Diagnosis and Therapy : https://a.co/d/6jU0EDWTarascon Pocket Pharmacopoeia: https://a.co/d/fZm4jqpFollow us on Instagram @livelaughlarp_podcastEmail us questions/topics at live.laugh.larp.podcast@gmail.comFind the Fit'n Fire YouTube Channel at https://www.youtube.com/fitnfireIntro/Outro Music: Elysium · Karl Casey

Persino la BBC si accorge del potenziale trasformativo del mining di Bitcoin. Noi lo diciamo da tempo: è il rapporto univoco tra corrente elettrica e mining ad essere l'incentivo più potente all'adozione. Africa, Asia, Sud America e persino l'Europa iniziano ad accorgersene.Inoltre: Electrum wallet pionierizza il coordinamente dei coinjoin usando il protocollo NOSTR, Boltz censura le transazioni nella blacklist OFAC, e arriva il BIP del "great consensus cleanup".It's showtime!

“Eventually, my dream would be to simulate a virtual cell.”—Demis HassabisThe aspiration to build the virtual cell is considered to be equivalent to a moonshot for digital biology. Recently, 42 leading life scientists published a paper in Cell on why this is so vital, and how it may ultimately be accomplished. This conversation is with 2 of the authors, Charlotte Bunne, now at EPFL and Steve Quake, a Professor at Stanford University, who heads up science at the Chan-Zuckerberg Initiative The audio (above) is available on iTunes and Spotify. The full video is linked here, at the top, and also can be found on YouTube.TRANSCRIPT WITH LINKS TO AUDIO Eric Topol (00:06):Hello, it's Eric Topol with Ground Truths and we've got a really hot topic today, the virtual cell. And what I think is extraordinarily important futuristic paper that recently appeared in the journal Cell and the first author, Charlotte Bunne from EPFL, previously at Stanford's Computer Science. And Steve Quake, a young friend of mine for many years who heads up the Chan Zuckerberg Initiative (CZI) as well as a professor at Stanford. So welcome, Charlotte and Steve.Steve Quake (00:42):Thanks, Eric. It's great to be here.Charlotte Bunne:Thanks for having me.Eric Topol (00:45):Yeah. So you wrote this article that Charlotte, the first author, and Steve, one of the senior authors, appeared in Cell in December and it just grabbed me, “How to build the virtual cell with artificial intelligence: Priorities and opportunities.” It's the holy grail of biology. We're in this era of digital biology and as you point out in the paper, it's a convergence of what's happening in AI, which is just moving at a velocity that's just so extraordinary and what's happening in biology. So maybe we can start off by, you had some 42 authors that I assume they congregated for a conference or something or how did you get 42 people to agree to the words in this paper?Steve Quake (01:33):We did. We had a meeting at CZI to bring community members together from many different parts of the community, from computer science to bioinformatics, AI experts, biologists who don't trust any of this. We wanted to have some real contrarians in the mix as well and have them have a conversation together about is there an opportunity here? What's the shape of it? What's realistic to expect? And that was sort of the genesis of the article.Eric Topol (02:02):And Charlotte, how did you get to be drafting the paper?Charlotte Bunne (02:09):So I did my postdoc with Aviv Regev at Genentech and Jure Leskovec at CZI and Jure was part of the residency program of CZI. And so, this is how we got involved and you had also prior work with Steve on the universal cell embedding. So this is how everything got started.Eric Topol (02:29):And it's actually amazing because it's a who's who of people who work in life science, AI and digital biology and omics. I mean it's pretty darn impressive. So I thought I'd start off with a quote in the article because it kind of tells a story of where this could go. So the quote was in the paper, “AIVC (artificial intelligence virtual cell) has the potential to revolutionize the scientific process, leading to future breakthroughs in biomedical research, personalized medicine, drug discovery, cell engineering, and programmable biology.” That's a pretty big statement. So maybe we can just kind of toss that around a bit and maybe give it a little more thoughts and color as to what you were positing there.Steve Quake (03:19):Yeah, Charlotte, you want me to take the first shot at that? Okay. So Eric, it is a bold claim and we have a really bold ambition here. We view that over the course of a decade, AI is going to provide the ability to make a transformative computational tool for biology. Right now, cell biology is 90% experimental and 10% computational, roughly speaking. And you've got to do just all kinds of tedious, expensive, challenging lab work to get to the answer. And I don't think AI is going to replace that, but it can invert the ratio. So within 10 years I think we can get to biology being 90% computational and 10% experimental. And the goal of the virtual cell is to build a tool that'll do that.Eric Topol (04:09):And I think a lot of people may not understand why it is considered the holy grail because it is the fundamental unit of life and it's incredibly complex. It's not just all the things happening in the cell with atoms and molecules and organelles and everything inside, but then there's also the interactions the cell to other cells in the outside tissue and world. So I mean it's really quite extraordinary challenge that you've taken on here. And I guess there's some debate, do we have the right foundation? We're going to get into foundation models in a second. A good friend of mine and part of this whole I think process that you got together, Eran Segal from Israel, he said, “We're at this tipping point…All the stars are aligned, and we have all the different components: the data, the compute, the modeling.” And in the paper you describe how we have over the last couple of decades have so many different data sets that are rich that are global initiatives. But then there's also questions. Do we really have the data? I think Bo Wang especially asked about that. Maybe Charlotte, what are your thoughts about data deficiency? There's a lot of data, but do you really have what we need before we bring them all together for this kind of single model that will get us some to the virtual cell?Charlotte Bunne (05:41):So I think, I mean one core idea of building this AIVC is that we basically can leverage all experimental data that is overall collected. So this also goes back to the point Steve just made. So meaning that we basically can integrate across many different studies data because we have AI algorithms or the architectures that power such an AIVC are able to integrate basically data sets on many different scales. So we are going a bit away from this dogma. I'm designing one algorithm from one dataset to this idea of I have an architecture that can take in multiple dataset on multiple scales. So this will help us a bit in being somewhat efficient with the type of experiments that we need to make and the type of experiments we need to conduct. And again, what Steve just said, ultimately, we can very much steer which data sets we need to collect.Charlotte Bunne (06:34):Currently, of course we don't have all the data that is sufficient. I mean in particular, I think most of the tissues we have, they are healthy tissues. We don't have all the disease phenotypes that we would like to measure, having patient data is always a very tricky case. We have mostly non-interventional data, meaning we have very limited understanding of somehow the effect of different perturbations. Perturbations that happen on many different scales in many different environments. So we need to collect a lot here. I think the overall journey that we are going with is that we take the data that we have, we make clever decisions on the data that we will collect in the future, and we have this also self-improving entity that is aware of what it doesn't know. So we need to be able to understand how well can I predict something on this somewhat regime. If I cannot, then we should focus our data collection effort into this. So I think that's not a present state, but this will basically also guide the future collection.Eric Topol (07:41):Speaking of data, one of the things I think that's fascinating is we saw how AlphaFold2 really revolutionized predicting proteins. But remember that was based on this extraordinary resource that had been built, the Protein Data Bank that enabled that. And for the virtual cell there's no such thing as a protein data bank. It's so much more as you emphasize Charlotte, it's so much dynamic and these perturbations that are just all across the board as you emphasize. Now the human cell atlas, which currently some tens of millions, but going into a billion cells, we learned that it used to be 200 cell types. Now I guess it's well over 5,000 and that we have 37 trillion cells approximately in the average person adult's body is a formidable map that's being made now. And I guess the idea that you're advancing is that we used to, and this goes back to a statement you made earlier, Steve, everything we did in science was hypothesis driven. But if we could get computational model of the virtual cell, then we can have AI exploration of the whole field. Is that really the nuts of this?Steve Quake (09:06):Yes. A couple thoughts on that, maybe Theo Karaletsos, our lead AI person at CZI says machine learning is the formalism through which we understand high dimensional data and I think that's a very deep statement. And biological systems are intrinsically very high dimensional. You've got 20,000 genes in the human genome in these cell atlases. You're measuring all of them at the same time in each single cell. And there's a lot of structure in the relationships of their gene expression there that is just not evident to the human eye. And for example, CELL by GENE, our database that collects all the aggregates, all of the single cell transcriptomic data is now over a hundred million cells. And as you mentioned, we're seeing ways to increase that by an order of magnitude in the near future. The project that Jure Leskovec and I worked on together that Charlotte referenced earlier was like a first attempt to build a foundational model on that data to discover some of the correlations and structure that was there.Steve Quake (10:14):And so, with a subset, I think it was the 20 or 30 million cells, we built a large language model and began asking it, what do you understand about the structure of this data? And it kind of discovered lineage relationships without us teaching it. We trained on a matrix of numbers, no biological information there, and it learned a lot about the relationships between cell type and lineage. And that emerged from that high dimensional structure, which was super pleasing to us and really, I mean for me personally gave me the confidence to say this stuff is going to work out. There is a future for the virtual cell. It's not some made up thing. There is real substance there and this is worth investing an enormous amount of CZIs resources in going forward and trying to rally the community around as a project.Eric Topol (11:04):Well yeah, the premise here is that there is a language of life, and you just made a good case that there is if you can predict, if you can query, if you can generate like that. It is reminiscent of the famous Go game of Lee Sedol, that world champion and how the machine came up with a move (Move 37) many, many years ago that no human would've anticipated and I think that's what you're getting at. And the ability for inference and reason now to add to this. So Charlotte, one of the things of course is about, well there's two terms in here that are unfamiliar to many of the listeners or viewers of this podcast, universal representations (UR) and virtual instrument (VIs) that you make a pretty significant part of how you are going about this virtual cell model. So could you describe that and also the embeddings as part of the universal representation (UR) because I think embeddings, or these meaningful relationships are key to what Steve was just talking about.Charlotte Bunne (12:25):Yes. So in order to somewhat leverage very different modalities in order to leverage basically modalities that will take measurements across different scales, like the idea is that we have large, may it be transformer models that might be very different. If I have imaging data, I have a vision transformer, if I have a text data, I have large language models that are designed of course for DNA then they have a very wide context and so on and so forth. But the idea is somewhat that we have models that are connected through the scales of biology because those scales we know. We know which components are somewhat involved or in measurements that are happening upstream. So we have the somewhat interconnection or very large model that will be trained on many different data and we have this internal model representation that somewhat capture everything they've seen. And so, this is what we call those universal representation (UR) that will exist across the scales of biology.Charlotte Bunne (13:22):And what is great about AI, and so I think this is a bit like a history of AI in short is the ability to predict the last years, the ability to generate, we can generate new hypothesis, we can generate modalities that we are missing. We can potentially generate certain cellular state, molecular state have a certain property, but I think what's really coming is this ability to reason. So we see this in those very large language models, the ability to reason about a hypothesis, how we can test it. So this is what those instruments ultimately need to do. So we need to be able to simulate the change of a perturbation on a cellular phenotype. So on the internal representation, the universal representation of a cell state, we need to simulate the fact the mutation has downstream and how this would propagate in our representations upstream. And we need to build many different type of virtual instruments that allow us to basically design and build all those capabilities that ultimately the AI virtual cell needs to possess that will then allow us to reason, to generate hypothesis, to basically predict the next experiment to conduct to predict the outcome of a perturbation experiment to in silico design, cellular states, molecular states, things like that. And this is why we make the separation between internal representation as well as those instruments that operate on those representations.Eric Topol (14:47):Yeah, that's what I really liked is that you basically described the architecture, how you're going to do this. By putting these URs into the VIs, having a decoder and a manipulator and you basically got the idea if you can bring all these different integrations about which of course is pending. Now there are obviously many naysayers here that this is impossible. One of them is this guy, Philip Ball. I don't know if you read the language, How Life Works. Now he's a science journalist and he's a prolific writer. He says, “Comparing life to a machine, a robot, a computer, sells it short. Life is a cascade of processes, each with a distinct integrity and autonomy, the logic of which has no parallel outside the living world.” Is he right? There's no way to model this. It's silly, it's too complex.Steve Quake (15:50):We don't know, alright. And it's great that there's naysayers. If everyone agreed this was doable, would it be worth doing? I mean the whole point is to take risks and get out and do something really challenging in the frontier where you don't know the answer. If we knew that it was doable, I wouldn't be interested in doing it. So I personally am happy that there's not a consensus.Eric Topol (16:16):Well, I mean to capture people's imagination here, if you're successful and you marshal a global effort, I don't know who's going to pay for it because it's a lot of work coming here going forward. But if you can do it, the question here is right today we talk about, oh let's make an organoid so we can figure out how to treat this person's cancer or understand this person's rare disease or whatever. And instead of having to wait weeks for this culture and all the expense and whatnot, you could just do it in a computer and in silico and you have this virtual twin of a person's cells and their tissue and whatnot. So the opportunity here is, I don't know if people get, this is just extraordinary and quick and cheap if you can get there. And it's such a bold initiative idea, who will pay for this do you think?Steve Quake (17:08):Well, CZI is putting an enormous amount of resources into it and it's a major project for us. We have been laying the groundwork for it. We recently put together what I think is if not the largest, one of the largest GPU supercomputer clusters for nonprofit basic science research that came online at the end of last year. And in fact in December we put out an RFA for the scientific community to propose using it to build models. And so we're sharing that resource within the scientific community as I think you appreciate, one of the real challenges in the field has been access to compute resources and industry has it academia at a much lower level. We are able to be somewhere in between, not quite at the level of a private company but the tech company but at a level beyond what most universities are being able to do and we're trying to use that to drive the field forward. We're also planning on launching RFAs we this year to help drive this project forward and funding people globally on that. And we are building a substantial internal effort within CZI to help drive this project forward.Eric Topol (18:17):I think it has the looks of the human genome project, which at time as you know when it was originally launched that people thought, oh, this is impossible. And then look what happened. It got done. And now the sequence of genome is just a commodity, very relatively, very inexpensive compared to what it used to be.Steve Quake (18:36):I think a lot about those parallels. And I will say one thing, Philip Ball, I will concede him the point, the cells are very complicated. The genome project, I mean the sort of genius there was to turn it from a biology problem to a chemistry problem, there is a test tube with a chemical and it work out the structure of that chemical. And if you can do that, the problem is solved. I think what it means to have the virtual cell is much more complex and ambiguous in terms of defining what it's going to do and when you're done. And so, we have our work cut out for us there to try to do that. And that's why a little bit, I established our North Star and CZI for the next decade as understanding the mysteries of the cell and that word mystery is very important to me. I think the molecules, as you pointed out earlier are understood, genome sequenced, protein structure solved or predicted, we know a lot about the molecules. Those are if not solved problems, pretty close to being solved. And the real mystery is how do they work together to create life in the cell? And that's what we're trying to answer with this virtual cell project.Eric Topol (19:43):Yeah, I think another thing that of course is happening concurrently to add the likelihood that you'll be successful is we've never seen the foundation models coming out in life science as they have in recent weeks and months. Never. I mean, I have a paper in Science tomorrow coming out summarizing the progress about not just RNA, DNA, ligands. I mean the whole idea, AlphaFold3, but now Boltz and so many others. It's just amazing how fast the torrent of new foundation models. So Charlotte, what do you think accounts for this? This is unprecedented in life science to see foundation models coming out at this clip on evolution on, I mean you name it, design of every different molecule of life or of course in cells included in that. What do you think is going on here?Charlotte Bunne (20:47):So on the one hand, of course we benefit profits and inherit from all the tremendous efforts that have been made in the last decades on assembling those data sets that are very, very standardized. CELLxGENE is very somehow AI friendly, as you can say, it is somewhat a platform that is easy to feed into algorithms, but at the same time we actually also see really new building mechanisms, design principles of AI algorithms in itself. So I think we have understood that in order to really make progress, build those systems that work well, we need to build AI tools that are designed for biological data. So to give you an easy example, if I use a large language model on text, it's not going to work out of the box for DNA because we have different reading directions, different context lens and many, many, many, many more.Charlotte Bunne (21:40):And if I look at standard computer vision where we can say AI really excels and I'm applying standard computer vision, vision transformers on multiplex images, they're not going to work because normal computer vision architectures, they always expect the same three inputs, RGB, right? In multiplex images, I'm measuring up to 150 proteins potentially in a single experiment, but every study will measure different proteins. So I deal with many different scales like larger scales and I used to attention mechanisms that we have in usual computer vision. Transformers are not going to work anymore, they're not going to scale. And at the same time, I need to be completely flexible in whatever input combination of channel I'm just going to face in this experiment. So this is what we right now did for example, in our very first work, inheriting the design principle that we laid out in the paper AI virtual cell and then come up with new AI architectures that are dealing with these very special requirements that biological data have.Charlotte Bunne (22:46):So we have now a lot of computer scientists that work very, very closely have a very good understanding of biologists. Biologists that are getting much and much more into the computer science. So people who are fluent in both languages somewhat, that are able to now build models that are adopted and designed for biological data. And we don't just take basically computer vision architectures that work well on street scenes and try to apply them on biological data. So it's just a very different way of thinking about it, starting constructing basically specialized architectures, besides of course the tremendous data efforts that have happened in the past.Eric Topol (23:24):Yeah, and we're not even talking about just sequence because we've also got imaging which has gone through a revolution, be able to image subcellular without having to use any types of stains that would disrupt cells. That's another part of the deep learning era that came along. One thing I thought was fascinating in the paper in Cell you wrote, “For instance, the Short Read Archive of biological sequence data holds over 14 petabytes of information, which is 1,000 times larger than the dataset used to train ChatGPT.” I mean that's a lot of tokens, that's a lot of stuff, compute resources. It's almost like you're going to need a DeepSeek type of way to get this. I mean not that DeepSeek as its claim to be so much more economical, but there's a data challenge here in terms of working with that massive amount that is different than the human language. That is our language, wouldn't you say?Steve Quake (24:35):So Eric, that brings to mind one of my favorite quotes from Sydney Brenner who is such a wit. And in 2000 at the sort of early first flush of success in genomics, he said, biology is drowning in a sea of data and starving for knowledge. A very deep statement, right? And that's a little bit what the motivation was for putting the Short Read Archive statistic into the paper there. And again, for me, part of the value of this endeavor of creating a virtual cell is it's a tool to help us translate data into knowledge.Eric Topol (25:14):Yeah, well there's two, I think phenomenal figures in your Cell paper. The first one that kicks across the capabilities of the virtual cell and the second that compares the virtual cell to the real or the physical cell. And we'll link that with this in the transcript. And the other thing we'll link is there's a nice Atlantic article, “A Virtual Cell Is a ‘Holy Grail' of Science. It's Getting Closer.” That might not be quite close as next week or year, but it's getting close and that's good for people who are not well grounded in this because it's much more taken out of the technical realm. This is really exciting. I mean what you're onto here and what's interesting, Steve, since I've known you for so many years earlier in your career you really worked on omics that is being DNA and RNA and in recent times you've made this switch to cells. Is that just because you're trying to anticipate the field or tell us a little bit about your migration.Steve Quake (26:23):Yeah, so a big part of my career has been trying to develop new measurement technologies that'll provide insight into biology. And decades ago that was understanding molecules. Now it's understanding more complex biological things like cells and it was like a natural progression. I mean we built the sequencers, sequenced the genomes, done. And it was clear that people were just going to do that at scale then and create lots of data. Hopefully knowledge would get out of that. But for me as an academic, I never thought I'd be in the position I'm in now was put it that way. I just wanted to keep running a small research group. So I realized I would have to get out of the genome thing and find the next frontier and it became this intersection of microfluidics and genomics, which as you know, I spent a lot of time developing microfluidic tools to analyze cells and try to do single cell biology to understand their heterogeneity. And that through a winding path led me to all these cell atlases and to where we are now.Eric Topol (27:26):Well, we're fortunate for that and also with your work with CZI to help propel that forward and I think it sounds like we're going to need a lot of help to get this thing done. Now Charlotte, as a computer scientist now at EPFL, what are you going to do to keep working on this and what's your career advice for people in computer science who have an interest in digital biology?Charlotte Bunne (27:51):So I work in particular on the prospect of using this to build diagnostic tools and to make diagnostics in the clinic easier because ultimately we have somewhat limited capabilities in the hospital to run deep omics, but the idea of being able to somewhat map with a cheaper and lighter modality or somewhat diagnostic test into something much richer because a model has been seeing all those different data and can basically contextualize it. It's very interesting. We've seen all those pathology foundation models. If I can always run an H&E, but then decide when to run deeper diagnostics to have a better or more accurate prediction, that is very powerful and it's ultimately reducing the costs, but the precision that we have in hospitals. So my faculty position right now is co-located between the School of Life Sciences, School of Computer Science. So I have a dual affiliation and I'm affiliated to the hospitals to actually make this possible and as a career advice, I think don't be shy and stick to your discipline.Charlotte Bunne (28:56):I have a bachelor's in biology, but I never only did biology. I have a PhD in computer science, which you would think a bachelor in biology not necessarily qualifies you through. So I think this interdisciplinarity also requires you to be very fluent, very comfortable in reading many different styles of papers and publications because a publication in a computer science venue will be very, very different from the way we write in biology. So don't stick to your study program, but just be free in selecting whatever course gets you closer to the knowledge you need in order to do the research or whatever task you are building and working on.Eric Topol (29:39):Well, Charlotte, the way you're set up there with this coalescence of life science and computer science is so ideal and so unusual here in the US, so that's fantastic. That's what we need and that's really the underpinning of how you're going to get to the virtual cells, getting these two communities together. And Steve, likewise, you were an engineer and somehow you became one of the pioneers of digital biology way back before it had that term, this interdisciplinary, transdisciplinary. We need so much of that in order for you all to be successful, right?Steve Quake (30:20):Absolutely. I mean there's so much great discovery to be done on the boundary between fields. I trained as a physicist and kind of made my career this boundary between physics and biology and technology development and it's just sort of been a gift that keeps on giving. You've got a new way to measure something, you discover something new scientifically and it just all suggests new things to measure. It's very self-reinforcing.Eric Topol (30:50):Now, a couple of people who you know well have made some pretty big statements about this whole era of digital biology and I think the virtual cell is perhaps the biggest initiative of all the digital biology ongoing efforts, but Jensen Huang wrote, “for the first time in human history, biology has the opportunity to be engineering, not science.” And Demis Hassabis wrote or said, ‘we're seeing engineering science, you have to build the artifact of interest first, and then once you have it, you can use the scientific method to reduce it down and understand its components.' Well here there's a lot to do to understand its components and if we can do that, for example, right now as both of AI drug discoveries and high gear and there's umpteen numbers of companies working on it, but it doesn't account for the cell. I mean it basically is protein, protein ligand interactions. What if we had drug discovery that was cell based? Could you comment about that? Because that doesn't even exist right now.Steve Quake (32:02):Yeah, I mean I can say something first, Charlotte, if you've got thoughts, I'm curious to hear them. So I do think AI approaches are going to be very useful designing molecules. And so, from the perspective of designing new therapeutics, whether they're small molecules or antibodies, yeah, I mean there's a ton of investment in that area that is a near term fruit, perfect thing for venture people to invest in and there's opportunity there. There's been enough proof of principle. However, I do agree with you that if you want to really understand what happens when you drug a target, you're going to want to have some model of the cell and maybe not just the cell, but all the different cell types of the body to understand where toxicity will come from if you have on-target toxicity and whether you get efficacy on the thing you're trying to do.Steve Quake (32:55):And so, we really hope that people will use the virtual cell models we're going to build as part of the drug discovery development process, I agree with you in a little of a blind spot and we think if we make something useful, people will be using it. The other thing I'll say on that point is I'm very enthusiastic about the future of cellular therapies and one of our big bets at CZI has been starting the New York Biohub, which is aimed at really being very ambitious about establishing the engineering and scientific foundations of how to engineer completely, radically more powerful cellular therapies. And the virtual cell is going to help them do that, right? It's going to be essential for them to achieve that mission.Eric Topol (33:39):I think you're pointing out one of the most important things going on in medicine today is how we didn't anticipate that live cell therapy, engineered cells and ideally off the shelf or in vivo, not just having to take them out and work on them outside the body, is a revolution ongoing, and it's not just in cancer, it's in autoimmune diseases and many others. So it's part of the virtual cell need. We need this. One of the things that's a misnomer, I want you both to comment on, we keep talking about single cell, single cell. And there's a paper spatial multi-omics this week, five different single cell scales all integrated. It's great, but we don't get to single cell. We're basically looking at 50 cells, 100 cells. We're not doing single cell because we're not going deep enough. Is that just a matter of time when we actually are doing, and of course the more we do get down to the single or a few cells, the more insights we're going to get. Would you comment about that? Because we have all this literature on single cell comes out every day, but we're not really there yet.Steve Quake (34:53):Charlotte, do you want to take a first pass at that and then I can say something?Charlotte Bunne (34:56):Yes. So it depends. So I think if we look at certain spatial proteomics, we still have subcellular resolutions. So of course, we always measure many different cells, but we are able to somewhat get down to resolution where we can look at certain colocalization of proteins. This also goes back to the point just made before having this very good environment to study drugs. If I want to build a new drug, if I want to build a new protein, the idea of building this multiscale model allows us to actually simulate different, somehow binding changes and binding because we simulate the effect of a drug. Ultimately, the redouts we have they are subcellular. So of course, we often in the spatial biology, we often have a bit like methods that are rather coarse they have a spot that averages over certain some cells like hundreds of cells or few cells.Charlotte Bunne (35:50):But I think we also have more and more technologies that are zooming in that are subcellular where we can actually tag or have those probe-based methods that allow us to zoom in. There's microscopy of individual cells to really capture them in 3D. They are of course not very high throughput yet, but it gives us also an idea of the morphology and how ultimately morphology determine certain somehow cellular properties or cellular phenotype. So I think there's lots of progress also on the experimental and that ultimately will back feed into the AI virtual cell, those models that will be fed by those data. Similarly, looking at dynamics, right, looking at live imaging of individual cells of their morphological changes. Also, this ultimately is data that we'll need to get a better understanding of disease mechanisms, cellular phenotypes functions, perturbation responses.Eric Topol (36:47):Right. Yes, Steve, you can comment on that and the amazing progress that we have made with space and time, spatial temporal resolution, spatial omics over these years, but that we still could go deeper in terms of getting to individual cells, right?Steve Quake (37:06):So, what can we do with a single cell? I'd say we are very mature in our ability to amplify and sequence the genome of a single cell, amplify and sequence the transcriptome of a single cell. You can ask is one cell enough to make a biological conclusion? And maybe I think what you're referring to is people want to see replicates and so you can ask how many cells do you need to see to have confidence in any given biological conclusion, which is a reasonable thing. It's a statistical question in good science. I think I've been very impressed with how the mass spec people have been doing recently. I think they've finally cracked the ability to look at proteins from single cells and they can look at a couple thousand proteins. That was I think one of these Nature method of the year things at the end of last year and deep visual proteomics.Eric Topol (37:59):Deep visual proteomics, yes.Steve Quake (38:00):Yeah, they are over the hump. Yeah, they are over the hump with single cell measurements. Part of what's missing right now I think is the ability to reliably do all of that on the same cell. So this is what Charlotte was referring to be able to do sort of multi-modal measurements on single cells. That's kind of in its infancy and there's a few examples, but there's a lot more work to be done on that. And I think also the fact that these measurements are all destructive right now, and so you're losing the ability to look how the cells evolve over time. You've got to say this time point, I'm going to dissect this thing and look at a state and I don't get to see what happens further down the road. So that's another future I think measurement challenge to be addressed.Eric Topol (38:42):And I think I'm just trying to identify some of the multitude of challenges in this extraordinarily bold initiative because there are no shortage and that's good about it. It is given people lots of work to do to overcome, override some of these challenges. Now before we wrap up, besides the fact that you point out that all the work has to be done and be validated in real experiments, not just live in a virtual AI world, but you also comment about the safety and ethics of this work and assuming you're going to gradually get there and be successful. So could either or both of you comment about that because it's very thoughtful that you're thinking already about that.Steve Quake (41:10):As scientists and members of the larger community, we want to be careful and ensure that we're interacting with people who said policy in a way that ensures that these tools are being used to advance the cause of science and not do things that are detrimental to human health and are used in a way that respects patient privacy. And so, the ethics around how you use all this with respect to individuals is going to be important to be thoughtful about from the beginning. And I also think there's an ethical question around what it means to be publishing papers and you don't want people to be forging papers using data from the virtual cell without being clear about where that came from and pretending that it was a real experiment. So there's issues around those sorts of ethics as well that need to be considered.Eric Topol (42:07):And of those 40 some authors, do you around the world, do you have the sense that you all work together to achieve this goal? Is there kind of a global bonding here that's going to collaborate?Steve Quake (42:23):I think this effort is going to go way beyond those 40 authors. It's going to include a much larger set of people and I'm really excited to see that evolve with time.Eric Topol (42:31):Yeah, no, it's really quite extraordinary how you kick this thing off and the paper is the blueprint for something that we are all going to anticipate that could change a lot of science and medicine. I mean we saw, as you mentioned, Steve, how that deep visual proteomics (DVP) saved lives. It was what I wrote a spatial medicine, no longer spatial biology. And so, the way that this can change the future of medicine, I think a lot of people just have to have a little bit of imagination that once we get there with this AIVC, that there's a lot in store that's really quite exciting. Well, I think this has been an invigorating review of that paper and some of the issues surrounding it. I couldn't be more enthusiastic for your success and ultimately where this could take us. Did I miss anything during the discussion that we should touch on before we wrap up?Steve Quake (43:31):Not from my perspective. It was a pleasure as always Eric, and a fun discussion.Charlotte Bunne (43:38):Thanks so much.Eric Topol (43:39):Well thank you both and all the co-authors of this paper. We're going to be following this with the great interest, and I think for most people listening, they may not know that this is in store for the future. Someday we will get there. I think one of the things to point out right now is the models we have today that large language models based on transformer architecture, they're going to continue to evolve. We're already seeing so much in inference and ability for reasoning to be exploited and not asking for prompts with immediate answers, but waiting for days to get back. A lot more work from a lot more computing resources. But we're going to get models in the future to fold this together. I think that's one of the things that you've touched on the paper so that whatever we have today in concert with what you've laid out, AI is just going to keep getting better.Eric Topol (44:39):The biology that these foundation models are going to get broader and more compelling as to their use cases. So that's why I believe in this. I don't see this as a static situation right now. I just think that you're anticipating the future, and we will have better models to be able to integrate this massive amount of what some people would consider disparate data sources. So thank you both and all your colleagues for writing this paper. I don't know how you got the 42 authors to agree to it all, which is great, and it's just a beginning of something that's a new frontier. So thanks very much.Steve Quake (45:19):Thank you, Eric.**********************************************Thanks for listening, watching or reading Ground Truths. Your subscription is greatly appreciated.If you found this podcast interesting please share it!That makes the work involved in putting these together especially worthwhile.All content on Ground Truths—newsletters, analyses, and podcasts—is free, open-access, with no ads..Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. And such support is becoming more vital In light of current changes of funding by US biomedical research at NIH and other governmental agencies.Thanks to my producer Jessica Nguyen and to Sinjun Balabanoff for audio and video support at Scripps Research. Get full access to Ground Truths at erictopol.substack.com/subscribe

Trumpot és kormányát perlik az amerikai őslakosok Telex     2025-03-10 05:42:03     Külföld USA A kormányzati leépítések sértik az amerikai kormány és az őslakosok között létrejött több száz éves egyezséget a felperesek szerint. Perelnek az osztrákok a Gysev miatt 24.hu     2025-03-10 05:55:30     Gazdaság Ausztria Bíróság A bíróságnak kell eldöntenie, rendben van-e, hogy a magyar fél erőből lenyomta a kisebbségben lévő üzlettársát. Európa védelmi erőfeszítései semmit nem érnek műholdak nélkül - márpedig azok Elon Musknál vannak vg.hu     2025-03-10 06:00:00     Külföld háború Washington Elon Musk Műhold Európa gigantikus fegyverkezési programot hirdetett meg, miután megijedt attól, hogy Washington magára hagyja. Műholdak nélkül azonban nem lehet háborúzni, márpedig ezen a téren óriási az öreg kontinens lemaradása. Még magasabb fokozatba kapcsolt a nyugdíjasok kifosztása mfor.hu     2025-03-10 05:54:09     Belföld Orbán Viktor Nyugdíj Index Áfa Március elejére még tovább drágultak az Mfor Nyugdíjas Árkosárban szereplő termékek. Az áremelkedés olyan mértékű, hogy a drágulás egyéves indexe ismét megközelítette a 20 százalékot. Lapunk ettől a hónaptól kezdve azt is kiszámolja, Orbán Viktor február végi ígérete alapján mennyi általános forgalmi adó járna vissza az időseknek, ha a termékeket a Boltzár jön: erre készülj, ha március 15-én vásárolnál Startlap Vásárlás     2025-03-10 05:47:13     Gazdaság Lidl Március 15. SPAR Auchan Aldi Tesco Penny Market Szombaton, a március 15-i nemzeti ünnepen több nagy üzletlánc - így az Aldi, a Lidl, a Tesco, a Spar, a Penny, az Auchan - zárva lesz, akadnak azonban kivételek. Lezárták a Balaton egyik ékkövét, tilos a látogatása Startlap Utazás     2025-03-10 06:03:29     Utazás Balaton Természetvédelem Határozatlan időre lezárták a Hegyestű területét, a Balaton-felvidék látványosságát természetvédelmi okokra hivatkozva nem lehet látogatni. Saját otthonában verték agyon a Juventust Rangadó     2025-03-09 22:49:30     Foci Olaszország Juventus Az Atalanta úgy lőtt négy gólt, hogy közben a torinóiak kapusa volt csapata legjobbja. Kerkez Milos látványos üzenetet küldött haza Marco Rossinak Magyar Nemzet     2025-03-10 05:05:00     Foci Marco Rossi Kerkez Milos A szövetségi kapitány kedden keretet hirdet, amelyben szokás szerint sok légiós kap helyet. Viharos idő váltja fel a napsütést Kiderül     2025-03-10 05:06:01     Időjárás A következő napokban változékonyra fordul időjárásunk. Gyakran számíthatunk esőre, helyenként akár zivatarok is kialakulhatnak. A további adásainkat keresd a podcast.hirstart.hu oldalunkon.

Trumpot és kormányát perlik az amerikai őslakosok Telex     2025-03-10 05:42:03     Külföld USA A kormányzati leépítések sértik az amerikai kormány és az őslakosok között létrejött több száz éves egyezséget a felperesek szerint. Perelnek az osztrákok a Gysev miatt 24.hu     2025-03-10 05:55:30     Gazdaság Ausztria Bíróság A bíróságnak kell eldöntenie, rendben van-e, hogy a magyar fél erőből lenyomta a kisebbségben lévő üzlettársát. Európa védelmi erőfeszítései semmit nem érnek műholdak nélkül - márpedig azok Elon Musknál vannak vg.hu     2025-03-10 06:00:00     Külföld háború Washington Elon Musk Műhold Európa gigantikus fegyverkezési programot hirdetett meg, miután megijedt attól, hogy Washington magára hagyja. Műholdak nélkül azonban nem lehet háborúzni, márpedig ezen a téren óriási az öreg kontinens lemaradása. Még magasabb fokozatba kapcsolt a nyugdíjasok kifosztása mfor.hu     2025-03-10 05:54:09     Belföld Orbán Viktor Nyugdíj Index Áfa Március elejére még tovább drágultak az Mfor Nyugdíjas Árkosárban szereplő termékek. Az áremelkedés olyan mértékű, hogy a drágulás egyéves indexe ismét megközelítette a 20 százalékot. Lapunk ettől a hónaptól kezdve azt is kiszámolja, Orbán Viktor február végi ígérete alapján mennyi általános forgalmi adó járna vissza az időseknek, ha a termékeket a Boltzár jön: erre készülj, ha március 15-én vásárolnál Startlap Vásárlás     2025-03-10 05:47:13     Gazdaság Lidl Március 15. SPAR Auchan Aldi Tesco Penny Market Szombaton, a március 15-i nemzeti ünnepen több nagy üzletlánc - így az Aldi, a Lidl, a Tesco, a Spar, a Penny, az Auchan - zárva lesz, akadnak azonban kivételek. Lezárták a Balaton egyik ékkövét, tilos a látogatása Startlap Utazás     2025-03-10 06:03:29     Utazás Balaton Természetvédelem Határozatlan időre lezárták a Hegyestű területét, a Balaton-felvidék látványosságát természetvédelmi okokra hivatkozva nem lehet látogatni. Saját otthonában verték agyon a Juventust Rangadó     2025-03-09 22:49:30     Foci Olaszország Juventus Az Atalanta úgy lőtt négy gólt, hogy közben a torinóiak kapusa volt csapata legjobbja. Kerkez Milos látványos üzenetet küldött haza Marco Rossinak Magyar Nemzet     2025-03-10 05:05:00     Foci Marco Rossi Kerkez Milos A szövetségi kapitány kedden keretet hirdet, amelyben szokás szerint sok légiós kap helyet. Viharos idő váltja fel a napsütést Kiderül     2025-03-10 05:06:01     Időjárás A következő napokban változékonyra fordul időjárásunk. Gyakran számíthatunk esőre, helyenként akár zivatarok is kialakulhatnak. A további adásainkat keresd a podcast.hirstart.hu oldalunkon.

Kilian Rausch is the founder and CEO of Boltz, a non-custodial Bitcoin bridge, allowing swaps between Bitcoin and layer 2 technologies such as Lightning, Liquid, and more to come. We discuss the history of Boltz, the current state of the Lightning network, the future of layer 2 technologies on Bitcoin, and much more!  Connect with Kilian: https://x.com/kilrau https://x.com/boltzhq https://boltz.exchange/ Connect with Us: https://www.bitcoininfinityshow.com/ https://bitcoininfinitystore.com https://primal.net/freedom https://primal.net/knut https://primal.net/luke https://twitter.com/BtcInfinityShow https://twitter.com/knutsvanholm https://twitter.com/lukedewolf Thanks to our sponsors - check out their websites for info: BitBox: https://bitbox.swiss/infinity StampSeed: https://www.stampseed.com/shop/21m-titanium-seed-plate.html Bitcoin Adviser: https://content.thebitcoinadviser.com/freedom ShopInBit: https://shopinbit.com/bitcoininfinity - Use code INFINITY for a €5 discount!    The Bitcoin Infinity Show is a Bitcoin podcast hosted by Knut Svanholm and Luke de Wolf.

Lenny and Jackie join Joe on this episode of the podcast to talk about their fight for conservative principles in Langlade County and how that impacts the rest of the state and even the country!See omnystudio.com/listener for privacy information.

This week Eric Hendricks joins us to help us solve problems, and bring some insight to RHEL 10 beta! -- During The Show -- 00:52 Intro Eric Hendricks ITGuyEric Red Hat Technical Marketer Fedora Podcast Host Steve's PSA - Spook (https://spook.boo/) Entities Other problems Help Steve Out - Firefox and authenticated proxy Mac OS breaking open source Gatekeeper 20:05 Threema for Messaging - Michael Technology is a tool for relationships Paid app Designed for private communication Checks a lot of boxes Network effect threematrix (https://github.com/bitbetterde/Threematrix) not updated recently Beeper 31:30 7 Inch Touch Screen Make the touch screen the primary display USB cable emulates a mouse Crash cart tech 35:07 News Wire Gnome 46.7 - gnome.org (https://discourse.gnome.org/t/gnome-46-7-released/25560) KDE Frameworks 6.9 - kde.org (https://kde.org/announcements/frameworks/6/6.9.0/) KDE Gear 24.12 - kde.org (https://kde.org/announcements/gear/24.12.0/) XFCE 4.20 - github.io (https://alexxcons.github.io/blogpost_14.html) QEMU 9.2 - qemu.org (https://wiki.qemu.org/ChangeLog/9.2) CentOS Stream 10 - centos.org (https://blog.centos.org/2024/12/introducing-centos-stream-10/) Red Hat has announced that CentOS Stream 10 is available. Kali Linux 2024.4 - bleepingcomputer.com (https://www.bleepingcomputer.com/news/security/kali-linux-20244-released-with-14-new-tools-deprecates-some-features/) Fedora Asahi 41 - forbes.com (https://www.forbes.com/sites/jasonevangelho/2024/12/17/fedora-asahi-remix-41-released-linux-on-your-apple-silicon-mac/) Fedora Asahi Remix 41 Released Pumakit - bleepingcomputer.com (https://www.bleepingcomputer.com/news/security/new-stealthy-pumakit-linux-rootkit-malware-spotted-in-the-wild/) Open Source Malware - helpnetsecurity.com (https://www.helpnetsecurity.com/2024/12/11/open-source-malware/) Boltz-1 - mit.edu (https://news.mit.edu/2024/researchers-introduce-boltz-1-open-source-model-predicting-biomolecular-structures-1217) 36:30 Self Hosting Hiccups SwiftFin app Jellyfin (https://jellyfin.org/) Nextcloud photo sync PhotoSync app Infuse app had to update the server side infuse plugin Immich (https://immich.app/) 47:10 RHEL 10 Public Beta Do Not install in production Relation between RHEL 10 Beta and CentOS 10 Special Interest Groups (SIGs) Get it for free with a developer account -- The Extra Credit Section -- For links to the articles and material referenced in this week's episode check out this week's page from our podcast dashboard! This Episode's Podcast Dashboard (http://podcast.asknoahshow.com/420) Phone Systems for Ask Noah provided by Voxtelesys (http://www.voxtelesys.com/asknoah) Join us in our dedicated chatroom #GeekLab:linuxdelta.com on Matrix (https://element.linuxdelta.com/#/room/#geeklab:linuxdelta.com) -- Stay In Touch -- Find all the resources for this show on the Ask Noah Dashboard Ask Noah Dashboard (http://www.asknoahshow.com) Need more help than a radio show can offer? Altispeed provides commercial IT services and they're excited to offer you a great deal for listening to the Ask Noah Show. Call today and ask about the discount for listeners of the Ask Noah Show! Altispeed Technologies (http://www.altispeed.com/) Contact Noah live [at] asknoahshow.com -- Twitter -- Noah - Kernellinux (https://twitter.com/kernellinux) Ask Noah Show (https://twitter.com/asknoahshow) Altispeed Technologies (https://twitter.com/altispeed) Special Guest: Eric Hendricks.

Debbie de Boltz, Head of Fundraising at Farleigh Hospice in Essex talks about the Christmas Tree recycling programme. #gardeningtips #gardeningadvice #winter #xmas #garden == We're delighted to have Gro-rite Horticulture sponsoring World Radio Gardening, find out about automatic pot watering systems available for mail order delivery: bit.ly/3wCPyHy For 2024, World Radio Gardening is planning a series of 4 exclusive newsletters. These will be loaded with extra special content and deals for you as a gardener. Make sure you don't miss out by signing up today via sign-up page: bit.ly/3RWwhYR The second newsletter is out now here: bit.ly/3RWwhYR – don't miss the next one! Also, don't forget – if you like what we do, why not tip Ken and team with a coffee – Buy us a coffee (bit.ly/48RLP75) – as a thank you for the work done to bring this website to life.

Thema: OMV kündigt Gas-Liefervertrag mit Gazprom

Thema: OMV kündigt Gas-Liefervertrag mit Gazprom

I'm joined by guests Stephan Livera, Rijndael & Ben Carman to go through the list.Housekeeping (00:05:29) Bitcoin Black Friday (00:06:05) AnchorWatch gains Lloyd's of London Coverholder statusMajor/Urgent Vulnerability Disclosures(00:10:25) Krux releases security fix for AES-CBC encryption flawBitcoin • Software Releases & Project Updates (00:16:05) Bitcoin-script-hints(00:17:14) BDK(00:17:38) BTCPay Server(00:19:53) Nunchuk Desktop(00:20:20) Proton Wallet(00:23:58) Bitcoin Keeper(00:24:40) Nix Bitcoin(00:25:09) Krux(00:26:49) RoboSats(00:26:57) Bitkey App(00:31:07) RewindBitcoin(00:35:15) Umbrel(00:35:32) ESP-Miner(00:35:36) Boltz web-app• Project Spotlight(00:35:43) Wallet Dev Kit(00:35:51) ScriptLab(00:36:04) Mempal(00:36:44) Debifi(00:37:41) Dart-bip85 package(00:37:45) Descriptors Go(00:37:47) Tick-tock-tui App(00:37:56) Awesome-Bitcoin-guide(00:38:30) BitAxe HAS Dashboard(00:38:39) Radpool(00:38:43) SatadelicaVulnerability Disclosures(00:39:16) Nearest neighbor attack - Exploiting nearby Wi-Fi for covert access(00:39:27) New Ghost Tap attack exploits NFC mobile payments(00:39:38) Graykey partially unlocks iPhones with iOS 18/18.0.1, from iPhone 12 to 16 series(00:40:38) OverSecured finds seven flaws in Android and Google Pixel, affecting millions of users(00:41:03) Apple urgently patches vulnerabilities affecting macOS and iOS(00:41:32) Decades-old security flaws in Ubuntu's Needrestart Package(00:41:48) Chinese man arrested in Bangkok for operating from a van-based SMS blaster(00:42:28) Five dollar wrench attackPrivacy & Other Related Bitcoin Projects• Software Releases & Project Updates(00:42:53) SimpleX(00:43:06) Signal• Project Spotlight(00:43:28) DeFlockLightning & L2(+)• Project Spotlight(00:43:56) Phoenix Server Lightning Wallet(00:44:32) Cashu Brrr(00:45:08) SING4SATS• Software Releases & Project Updates(00:45:44) Primal(00:47:27) LND(00:48:05) CDK Cashu Development Kit(00:48:36) Phoenix Wallet(00:48:47) Zeus(00:49:56) Nutstash(00:49:59) Nutshell(00:50:07) Fountain(00:50:10) Breez SDK(00:50:14) Lnp2pBot(00:50:17) BoardWalk(00:50:19) Geyser(00:50:20) Aqua Wallet(00:50:47) Clams RemoteNostr • Project spotlight (00:50:52) NDK Mobile(00:50:55) Olas(00:51:26) Knox(00:51:32) Nostraut(00:51:35) Ezdvm(00:51:40) Futr(00:51:45) Nosey(00:51:49) Nos2x for Firefox• Software Releases & Project Updates(00:52:00) GifBuddyBoosts(00:52:30) Shoutout to top boosters Chris, podconf & btconboardNews & Noteworthy• Bitcoin(00:55:05) Chaincode Labs launches the 2025 BOSS program• Nostr(00:55:49) Kagi HQ joins Nostr• Business & Finance(00:57:06) Block, Inc. unveils Proto(00:57:11) Casa introduces Casa Enterprise(00:57:30) Swan Bitcoin sues former law firm for conflict of interest in Tether case• Tradfi(00:57:46) Revolut X expands to 30 European countries(00:57:58) Newmarket Capital, launches Battery Finance• Funding(00:58:06) OpenSats announces long term support and educational grants• Mining(00:58:12) Russia bans winter digital currency mining in Siberia• Privacy(00:58:40) U.S. Congress critiques Tornado Cash and urges for stricter regulations(00:58:44) Chinese government employees are selling citizen data for profit(00:59:20) Mullvad VPN cancels remaining PayPal subscriptions and aligns with privacy-focused policy• Cryptography(01:00:59) Two mathematicians break an 18-year record with an elliptic curve of rank 29• Events(01:01:22) SATS'N'FACTS, Bitcoin Technical Unconference(01:01:26) Hackalajara, Guadalajara's first Bitcoin-focused hackathon(01:01:39) Bengaluru BitDevs SummitReads:(01:01:46) Here's a list of our top recently published readsLinks & Contacts: Website: https://bitcoin.review/ Substack: https://substack.bitcoin.review/ Twitter: https://twitter.com/bitcoinreviewhq NVK Twitter: https://twitter.com/nvk Telegram: https://t.me/BitcoinReviewPod Email: producer@coinkite.com Nostr & LN: ⚡nvk@nvk.org (not an email!) Full show notes: https://bitcoin.review/podcast/episode-88

In this episode Brian Barney sits down with his friend Jim Boltz. Jim is an incredibly talented artist and avid outdoorsman. Jim has some great perspectives on being productive, finding happiness and living one's best life. The guys have a great conversation including discussing practices to help mitigate stress and making changes to the way we think about things. Black Ovis - www.blackovis.com Camo Fire - www.camofire.com Eberlestock - www.eberlestock.com Kryptek - www.kryptek.com Mathews - www.mathews.com Savage - www.savagearms.com Sig Sauer - www.sigsauer.com/electro-optics.html Silencer Central - www.silencercentral.com Zamberlan - www.zamberlan.com

The stars aligned just right for this episode as a very special guest @Boltz_n_Holes joined me and we had a great talk about Guns, shooting competition,practice,working out and of course favorite cereal. So give this a thumbs up while you listen and ENJOY IT!! Please follow my guest on Instagram you'll be happy you did.https://www.instagram.com/boltz_n_holez?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw== Please check out the store at https://akallday.net/ and help support all the things we do and it is greatly appreciated.

Imagina crear una empresa, 100% legal y que no toque en ningún momento el sistema fiat tradicional. Sin cuentas bancarias. Nunca. Eso es Boltz Exchange, que además es un servicio increíble - que debes conocer - para pasar de Bitcoin a Lightning, Liquid y Rootstock de la forma más cómoda. En el pod de hoy, Kilian, su CEO, me lo cuenta todo tanto a nivel empresa como a nivel proyecto bitcoin. LINKS: Boltz exchange: https://boltz.exchange/ Boltz en testnet: https://testnet.boltz.exchange/ Nostr Boltz: https://njump.me/nprofile1qyfhwumn8ghj7ur4wfcxcetsv9njuetn9uqsuamnwvaz7tmwdaejumr0dshsqgqvxu04ak2swesngslgxvwykcyz3mt8hn004gtf376ua8tmx2zllv2rhafu X: https://x.com/Boltzhq Escúchame en Fountain aquí https://fountain.fm/lunaticoin Más información en mi BLOG https://lunaticoin.blog Nostr: ⁠https://njump.me/nprofile1qy88wumn8ghj7mn0wvhxcmmv9uq3qamnwvaz7tmwdaehgu3wd4hk6tcqyqjwxlq7tvxgh2xauf65hnluvw6m9x0cqe8clwfghne3twwyje0nk0weuag⁠ X: https://twitter.com/lunaticoin Canal de Telegram: https://t.me/lunaticoinpodcast Contenido adicional en mi Patreon: https://www.patreon.com/lunaticoin Mención especial a los sponsors de este podcast: Compra bitcoin en HodlHodl: https://bit.ly/hodlhodl-luna Custodia tus bitcoin con Coldcard de Coinkite: https://bit.ly/coinkite-lunaticoin Vive con bitcoin en Bitrefill: https://bit.ly/Luna_Bitrefill Crea, edita y comparte hypertexto sin que nadie te frene en Seed Hypermedia (antes Mintter) https://seedhypermedia.com/ Aprende Bitcoin desde 0 con la Mentoría de Custodia https://bit.ly/Luna_Semilla

In my latest episode, I chat with Brooke Boltz, founder of Boltz Legal. Raised in Volusia County and a Political Science graduate, Brooke spent years in civil litigation before starting her own firm in 2017. Her unique experience working for and against insurance companies gives her a strategic edge in representing clients. I met Brooke at a rotary club where she was presenting on personal injury, and she inspired me to take action and start my own grassroots marketing. Brooke is simply a wonderful person, dedicated attorney, and loving mother of three. Don't miss this episode to hear her incredible journey and insights. Become a supporter of this podcast: https://www.spreaker.com/podcast/the-lawman-s-lounge--4267400/support.

Just like how English is the international language of business, Bitcoin's lightning network is how various layers and apps and products will ‘talk' to each other. Roy Sheinfeld, founder and CEO of Breez (@Breez_Tech) rejoins me to talk about updates in lightning and what's new with Breez SDK.  We discuss the various layers and ways of interacting with Bitcoin and lightning, using Liquid (@Liquid_BTC) with swaps, and Bitcoin as a medium of exchange.  Summary: In this conversation, Stephan and Roy discuss the current state of Bitcoin and Lightning. They explore the contrasting narratives of Lightning startups shutting down and new partnerships being formed. Roy emphasizes that Lightning is a manifestation of the payments use case of Bitcoin and that the majority of Bitcoin usage is still for trading and as an asset. He believes that the value proposition of Bitcoin lies in its potential as peer-to-peer electronic cash. They also discuss the role of custodial and non-custodial solutions, the regulatory landscape, and the control exerted by governments and private companies.  Roy argues that Lightning is the common language of the Bitcoin economy, enabling interoperability between different subnetworks and protocols. He highlights the importance of Lightning as a rail for communication and the incentives for moving Bitcoin within the Lightning network. Breez is working on integrating Lightning Network into existing applications to make Bitcoin more accessible and usable. They have developed the Breez SDK, which allows developers to easily integrate Lightning functionality into their apps.  Breez offers two implementations: Greenlight, which is a pure Lightning implementation, and Liquid, which is a nodeless implementation of Lightning using the Liquid sidechain. The goal is to provide a seamless user experience for Lightning transactions and make Bitcoin a common language for payments. Breez is also exploring hybrid solutions and partnerships to expand the adoption of Lightning. Key Takeaways: The majority of Bitcoin usage is currently for trading and as an asset, but the value proposition lies in its potential as peer-to-peer electronic cash. Lightning is the common language of the Bitcoin economy, enabling interoperability between different subnetworks and protocols. There is a need for both custodial and non-custodial solutions, with a growing focus on self-custodial options. The regulatory landscape and control exerted by governments and private companies pose challenges to the use of Bitcoin as a medium of exchange. Incentives within the Lightning network encourage the movement of Bitcoin and the use of Lightning as a rail for communication. Breez is focused on integrating Lightning Network into existing applications to make Bitcoin more accessible and usable. They have developed the Breez SDK, which allows developers to easily integrate Lightning functionality into their apps. Breez offers 2 implementations: Greenlight, which is a pure Lightning implementation, and Liquid, which is a nodeless implementation of Lightning using the Liquid sidechain. The goal is to provide a seamless user experience for Lightning transactions and make Bitcoin a common language for payments. Breez is exploring hybrid solutions and partnerships to expand the adoption of Lightning. Timestamps: (00:00) - Intro (00:56) - The current state of Bitcoin & Lightning network (03:17) - Mutiny wallet's contributions to Bitcoin (04:54) - Regulatory landscape, Dollarisation of Bitcoin & Importance of non-custodial solutions (14:43) - Sponsor (16:07) - HODLing vs Spending Bitcoin (18:55) - Lightning is the common language of the Bitcoin economy (22:50) - Lightning: Bitcoin's interoperability protocol (29:42) - Liquid network - overview (31:27) - Existing frictions with the Lightning network; Greenlight implementation, Liquid implementation  (36:55) - Sponsors (38:57) - Boltz.exchange ( @Boltzhq ) X Breez (40:33) - Differences b/w Greenlight & Liquid implementation (49:00) - Lightning on Liquid soon? (52:25) - Possible future integrations & way forward for Breez (57:25) - Outro Links:  https://medium.com/breez-technology/lightning-is-the-common-language-of-the-bitcoin-economy-eb8515341c11  https://x.com/Breez_Tech  Sponsors: CoinKite.com (code LIVERA) Mempool.space Nomadcapitalist.com/apply Stephan Livera links: Follow me on X: @stephanlivera Subscribe to the podcast Subscribe to Substack

She's a Mom...and entrepreneur, and a former professional football player! She also leads a very successful law firm in Oviedo. Brooke Boltz shares how she went from being a PK (preacher's kid) to running an insurance and personal injury law firm.

Send us a Text Message.Brooke Boltz - Managing Attorney at Boltz Legal - invites us into her faith journey including growing up a pastor's kid and a rule follower; being surrounded by friends that didn't share the same values, but respecting their choices; how her commitment to staying pure until marriage made relationships almost non-existent; the confusion around her divorce; the premature birth of her daughter; how she used a guitar and a dictaphone to worship in the hospital; playing tackle football on the boys team; how a degree in political science actually steered her to her career in law; moving from the defense to the plaintiff side and the challenges, and eventual blessing, that came with that; how her own firm gives her a freedom to express her faith and much more. https://boltzlegal.com/Support the Show.

"Submarine Swaps employ hash time-locked contracts (HTLCs), which in layperson’s terms, enable two transactions (both sides of the swap) to happen simultaneously by linking them together cryptographically inside of a smart contract. Using this technology, there is no way for one exchange to occur without the other occurring at the same moment. This is the most trustless solution that exists for moving sats between Bitcoin layers." ~ Frank Corva What role do trustless bridges play in connecting Bitcoin's various layers? Dive into the world of Boltz, a non-custodial exchange service that's quietly revolutionizing how we move Bitcoin between the base chain, Lightning Network, and Liquid. Discover how atomic swaps and submarine swaps are making cross-layer transfers more efficient and seamless. What implications do they hold for the future of Bitcoin's layered ecosystem? Check out the original article at Between Bitcoin Layers: Boltz Builds Trustless Transfers (Link: https://tinyurl.com/3rv7xuar) Links to check out: Boltz (Link: boltz.exchange) What Are Taproot Swaps? by Che Kohler (Link: https://tinyurl.com/4kwekbar) Breeze Wallet [iOS (Link: https://tinyurl.com/3yyfeh6d) / Android (Link: https://tinyurl.com/mr2xdatd)] Aqua Wallet [iOS (Link: https://tinyurl.com/3uekhxhu)/ Android (Link: https://tinyurl.com/358wjk8x)] Phoenix Wallet [iOS (Link: https://tinyurl.com/4np9k8me) / Android (Link: https://tinyurl.com/2hkwbrer)] Pears (Link: https://pears.com/) Keet (Link: https://keet.io/) Nostr.com (Link: https://nostr.com/) Nostr.how (Link: https://nostr.how/) Hedgehog: A protocol for improved layer two bitcoin payments (Link: https://github.com/supertestnet/hedgehog) Host Links ⁠Guy on Nostr ⁠(Link: http://tinyurl.com/2xc96ney) ⁠Guy on X ⁠(Link: https://twitter.com/theguyswann) Guy on Instagram (Link: https://www.instagram.com/theguyswann) Guy on TikTok (Link: https://www.tiktok.com/@theguyswann) Guy on YouTube (Link: https://www.youtube.com/@theguyswann) ⁠Bitcoin Audible on X⁠ (Link: https://twitter.com/BitcoinAudible)

Ashley is a mom of 3 and is currently nursing her 18 month old twins girls. She breastfed her son through 16 months and has started the process of slowly weaning her twins. She shares her everyday life and relatable mom content as a 2 mom family on instagram @lovedby2moms. This episode is brought to you by the free Extended Breastfeeding Quiz. Click here to learn which of the 5 stages of extended breastfeeding you are in today!

Rachel Boltz is the founder of Boltz Media. who are a full service digital marketing agency. and serve business owners who are looking for a striking difference in digital marketing and also the co-host of the Ms. Biz Podcast. Our podcast is geared toward Christian female business owners with a focus on extreme marketing.Here's where to find more:www.boltzmedia.comhttps://www.facebook.com/BoltzMedia1https://www.instagram.com/boltzmedia1https://www.tiktok.com/@boltz_mediahttps://twitter.com/boltz_mediahttps://www.linkedin.com/company/boltzmediahttps://www.youtube.com/@boltzmedia1___________________________________________________________Welcome to The Unforget Yourself Show where we use the power of woo and the proof of science to help you identify your blind spots, and get over your own bullshit so that you can do the fucking thing you ACTUALLY want to do!We're Mark and Katie, the founders of Unforget Yourself and the creators of the Unforget Yourself System and on this podcast, we're here to share REAL conversations about what goes on inside the heart and minds of those brave and crazy enough to start their own business. From the accidental entrepreneur to the laser-focused CEO, we find out how they got to where they are today, not by hearing the go-to story of their success, but talking about how we all have our own BS to deal with and it's through facing ourselves that we find a way to do the fucking thing.Along the way, we hope to show you that YOU are the most important asset in your business (and your life - duh!). Being a business owner is tough! With vulnerability and humor, we get to the real story behind their success and show you that you're not alone._____________________Find all our links to all the things like the socials, how to work with us and how to apply to be on the podcast here: https://linktr.ee/unforgetyourself

Brooke Boltz is the founder of Boltz Legal - Brooke is a 15 year attorney, practicing injury and insurance law and also has a podcast called "Ms. Biz".Here's where to find more:https://www.facebook.com/BoltzLegal?mibextid=LQQJ4dhttps://www.facebook.com/MsBizPodcast?mibextid=LQQJ4dWww.boltzlegal.comWww.msbiz.com___________________________________________________________Welcome to The Unforget Yourself Show where we use the power of woo and the proof of science to help you identify your blind spots, and get over your own bullshit so that you can do the fucking thing you ACTUALLY want to do!We're Mark and Katie, the founders of Unforget Yourself and the creators of the Unforget Yourself System and on this podcast, we're here to share REAL conversations about what goes on inside the heart and minds of those brave and crazy enough to start their own business. From the accidental entrepreneur to the laser-focused CEO, we find out how they got to where they are today, not by hearing the go-to story of their success, but talking about how we all have our own BS to deal with and it's through facing ourselves that we find a way to do the fucking thing.Along the way, we hope to show you that YOU are the most important asset in your business (and your life - duh!). Being a business owner is tough! With vulnerability and humor, we get to the real story behind their success and show you that you're not alone._____________________Find all our links to all the things like the socials, how to work with us and how to apply to be on the podcast here: https://linktr.ee/unforgetyourself

► Bitcoin Needs Unstoppable Privacy Tools! We are joined by creator of the boltz exchange Michael, this 20 something wiz kid is attempting to solve some of the biggest challenges for scaling and privacy. ✔ Special Guest/Fireside Chat: ► @michael1011at ► https://boltz.exchange/ ► https://twitter.com/boltzhq ► michael1011.at ✔ Numbers: ► https://x.com/jebus/status/1788615986607735132?s=61&t=KglbeFNESvZWy6xNoYX4YQ ► https://x.com/italiansatoshi/status/1787221142035390808?s=52&t=CKH2brGypO5fEYTgQ-EFhQ ✔ REKT: ► https://twitter.com/bitcoinnewscom/status/1788227216708411573?s=52&t=CKH2brGypO5fEYTgQ-EFhQ ► https://twitter.com/mononautical/status/1788739557418320323?s=61&t=KglbeFNESvZWy6xNoYX4YQ ✔ Bitcoin Hopium: ► https://en.bitcoinsistemi.com/is-china-the-next-step-for-bitcoin-and-ethereum-etfs-much-talked-about-btc-eth-step-from-the-giant-company/ ► https://en.wikipedia.org/wiki/Harvest_Fund_Management ► https://www.harvestglobal.us/hgi/index.php ✔ Twitter Handles: @coinicarus @AEHW1 ✔ ShoutOuts: ► @BitkoYinowsky - our PlebUnderground Logo ► @WorldofRusty - Our YT backgrounds and segment transitions ► @luckyredfish - Outro Graphic ► @plebsTaverne - Intro video ► @robbieP808x - Outro music ✔ Links Mentioned: ► https://timechaincalendar.com/en ► https://timechainstats.com/ ✔ Check out our Sponsor, support Bitcoin ONLY Businesses: ► https://cyphersafe.io/ We offer a full line of physical stainless steel and brass products to help you protect your bitcoin from various modes of failure. CypherSafe creates metal BIP39 / SLIP39 bitcoin seed word storage devices that backup your bitcoin wallet and protect them from physical disaster ► http://btcpins.com/ Pick up the latest pin about the latest thing! Btcpins has it all; rare bitcoiner themed pins, stickers, apparel and a whole lot more. Get a 5% discount on any of the iconic gear found here using code ‘plebunderground' ► https://proofofink.com/ Come check out awesome high quality clothes using screen printed tech for long lasting bright colorful prints that last. NO third parties, Bitcoin Only Designs! Get a 5.8% discount on any of the amazing gear found here using code ‘plebunderground' For Awesome pleb content daily http://plebunderground.com/ GM #Bitcoin (mon-fri 10:00 am ET) and The #Bitcoin Council of Autism Spaces on twitter Timecodes: 0:00 - Intro 00:24 - Waltons Rap 02:04 - Numbers 19:00 - FiresideChat: Michael(boltz Exchange) 41:13 - REKT 51:41 - Hopium #Bitcoin #crypto #cryptocurrency #weekly The information provided by Pleb Underground ("we," "us," or "our") on Youtube.com (the "Site") our show is for general informational purposes only. All information on the show is provided in good faith, however we make no representation or warranty of any kind, express or implied, regarding the accuracy, adequacy, validity, reliability, availability, or completeness of any information on the Site. UNDER NO CIRCUMSTANCE SHALL WE HAVE ANY LIABILITY TO YOU FOR ANY LOSS OR DAMAGE OF ANY KIND INCURRED AS A RESULT OF THE USE OF THE SHOW OR RELIANCE ON ANY INFORMATION PROVIDED ON THE SHOW. YOUR USE OF THE SHOW AND YOUR RELIANCE ON ANY INFORMATION ON THE SHOW IS SOLELY AT YOUR OWN RISK.

- OpenSats Receives Additional $21M Funding from #startsmall Initiative https://opensats.org/blog/opensats-receives-additional-funding-of-dollar21m-from-startsmall - Block to Invest 10% of Bitcoin Profits into BTC Each Month for the Rest of 2024 https://www.nobsbitcoin.com/block-to-invest-10-of-bitcoin-profits-into-btc-each-month/ - Spiral Renews Grants to Bitcoin Zavior and Matt Morehouse https://www.nobsbitcoin.com/spiral-renews-grants-to-bitcoin-zavior-matt-morehouse/ - Lightning Payments Biz Mash to Shut Down https://x.com/getmash/status/1787863323825893499 - AgoraDesk / LocalMonero P2P Exchange to Shut Down on November 7 https://www.nobsbitcoin.com/agoradesk-localmonero-shutting-down/ - libsecp256k1 v0.5.0: Faster Key Generation & Signing https://www.nobsbitcoin.com/libsecp256k1-v0-5-0/ - COLDCARD Mk4 v5.3.0 and Q v1.2.0Q: Shared Codebase https://www.nobsbitcoin.com/coldcard-mk4-v5-3-0-and-v1-2-0q/ - Geyser v0.8.0: On-chain to Lightning Donation Swaps via Boltz https://www.nobsbitcoin.com/geyser-v0-8-0/ - LDK v0.0.123: 'BOLT12 Dust Sweeping' https://www.nobsbitcoin.com/ldk-v0-0-123/ - BDK v1.0.0-alpha.10: Improved Address API, Simplified Esplora API https://www.nobsbitcoin.com/bdk-v1-0-0-alpha-10/ - Zeus v0.8.4: Select Wallet/Node on Start-up https://www.nobsbitcoin.com/zeus-v0-8-4/ - Bitcoin Keeper v1.2.6: Canary Wallets to Detect Unauthorized Key Usage https://www.nobsbitcoin.com/bitcoin-keeper-v1-2-6/ - Emessbee: Construct Coinjoin Transactions Without a Coordinator https://www.nobsbitcoin.com/introducing-emessbee/ - Blockstream Green Desktop v2.0.5: Add Singlesig Watch-only Wallets & More https://www.nobsbitcoin.com/blockstream-green-desktop-v2-0-5/ - Swan Discloses Mining Partnership with Tether https://twitter.com/Swan/status/1787951439576232315 - Tether Enhances Compliance Measures with Chainalysis Ecosystem Monitoring Solution https://tether.io/news/tether-enhances-compliance-measures-with-chainalysis-ecosystem-monitoring-solution/ 3:41 - US/Japan swap line 8:22 - Dashboard 11:16 - OpenSats receives funding 18:52 - Social engineering attacks 27:41 - Block investing in bitcoin 32:19 - Spiral grants 33:31 - Mash 36:12 - AgoraDeak shutting down 37:31 - Boosts 40:09 - Open source fixes this 44:17 - Software updates 52:25 - Pubkey RHR 56:29 - Swan mining 1:01:56 - Tether Chainalysis 1:04:57 - Final thoughts Shoutout to our sponsors: Unchained Capital https://unchained.com/concierge/ Coinkite https://coinkite.com/ TFTC Merch is Available: Shop Now https://merch.tftc.io/ Join the TFTC Movement: Main YT Channel https://www.youtube.com/c/TFTC21/videos Clips YT Channel https://www.youtube.com/channel/UCUQcW3jxfQfEUS8kqR5pJtQ Website https://tftc.io/ Twitter https://twitter.com/tftc21 Instagram https://www.instagram.com/tftc.io/ Follow Marty Bent: Twitter https://twitter.com/martybent Newsletter https://tftc.io/martys-bent/ Podcast https://tftc.io/podcasts/ Follow Odell: Twitter https://twitter.com/ODELL Newsletter https://tftc.io/the-sat-standard/ Podcast https://citadeldispatch.com/

Welcome back to the regularly scheduled 2nd Opinion Podcast! We are back in full swing with the show and are excited to share our opinions! We plan on setting up a lot of content for the future, including interviews, bringing back our Head2Head segment, as well as having our co-host rejoin the show! We hope you enjoy this episode of the podcast and please make sure to subscribe! “In this audio episode, Caleb “Soleb” Gayle and Boltz discuss Star Wars: Outlaws, Xbox's New Console Coming in 2028, Helldivers II, and more!" “LIFE A BITCH, HOW ABOUT YOU?” Show introduction, this used to be called “what you've been drinking and gaming” but …who has time for that now? GAMING TOPICS 1. "Star Wars Outlaws Gets New Trailer and a Release Date" “In-depth with a discussion on Star Wars: Outlaws.What we've seen so far and what we want from this game" 2. “Players Have Defeated An Entire Enemy Faction In Helldivers 2 but now they are back!” “Discuss the ongoing development of Helldivers 2, the eradication of the Automatons, and the future of the game!” 3. Xbox Moving 'Full Speed Ahead' on Next-Gen Console 4. Ermac Coming to Mortal Kombat 1 on April 16th 5. All 8 Episodes Of Amazon's Fallout TV Series Now Dropping One Day Earlier 6. Motive Studio To Work On Battlefield As Iron Man Game Hits 'Major Internal Milestone' **END SHOW** --- Send in a voice message: https://podcasters.spotify.com/pod/show/2ndopinionpodcast/message

Welcome back to the regularly scheduled 2nd Opinion Podcast! We are back in full swing with the show and are excited to share our opinions! We plan on setting up a lot of content for the future, including interviews, bringing back our Head2Head segment, as well as having our co-host rejoin the show! We hope you enjoy this episode of the podcast and please make sure to subscribe! “In this audio episode, Caleb “Soleb” Gayle and Boltz discuss Dragons Dogma II, Video Game Shows and Movies, New Consoles Already Coming, and more!" “LIFE A BITCH, HOW ABOUT YOU?” Show introduction, this used to be called “what you've been drinking and gaming” but …who has time for that now? GAMING TOPICS 1. Dragons Dogma II, Is it a Big Deal that it has MicroTransactions? 2. Should Video Game Shows & Movies Follow Game Lore? 3. New Video Game Consoles are already on the way? 4. New Video Game Coming Soon! **END SHOW** --- Send in a voice message: https://podcasters.spotify.com/pod/show/2ndopinionpodcast/message

Welcome back to the regularly scheduled 2nd Opinion Podcast! Things have been rough these past few weeks, with the holidays upon us things have been getting crazier every day! We plan on setting up a lot of content for the future, including interviews, bringing back our Head2Head segment, as well as having our co-host rejoin the show! We hope you enjoy this episode of the podcast and please make sure to subscribe! “In this audio episode, Caleb “Soleb” Gayle and Boltz discuss Toys for Bob, Fallout 5, and more! “LIFE A BITCH, HOW ABOUT YOU?” Show introduction, this used to be called “what you've been drinking and gaming” but …who has time for that now? GAMING TOPICS 1. "Toys for Bob is Going Independent" 2. "Marvel 1943: Rise of Hydra has been Announced" 3. "Todd Howard talks Fallout 5" "END SHOW" --- Send in a voice message: https://podcasters.spotify.com/pod/show/2ndopinionpodcast/message

How do we interact with Bitcoin in a multi layer world? What cost savings and trade offs are necessary here? What even counts as a layer? Kilian from boltz.exchange joins me to talk about swapping across Bitcoin on-chain, Lightning and Liquid. We discuss: How swapping works What makes it atomic and non-custodial What counts as layer 2 Fee savings and trade offs Links: X: @kilrau Site: boltz.exchange X: @boltzhq Taproot feature blog post: Introducing Taproot Swaps: Putting the "Fun" Back into Refunds!  Sponsors: Swan.com (code LIVERA) CoinKite.com (code LIVERA) Mempool.space Nomadcapitalist.com Stephan Livera links: Follow me on X: @stephanlivera Subscribe to the podcast Subscribe to Substack Chapters/Timestamps: 00:00 - Introduction and Background 03:07 - Bolts.exchange: Moving Between Bitcoin Layers 05:35 - Use Cases for Lightning Service Providers 09:45 - Enhancing Wallet Functionality 13:20 - Non-Custodial Atomic Swaps 21:43 - Coinkite.com 23:07 - NomadCapitalist.com 24:25 - Fees and Fee Savings 29:35 - Trust Model of Liquid 32:40 - Regulatory Risks for Liquid 37:10 - Transaction Limits on Liquid 38:58 - Mempool.space 39:59 - Swan.com 41:02 - Scalability of Liquid 44:15 - Integration of Liquid with Other Services and Wallets 51:22 - Pragmatism in Bitcoin Adoption 55:45 - Operating in a High-Fee Environment 57:45 - Closing Thoughts

We were very fortunate to have Al Boltz from A Scent Like Wolves on the podcast to talk about their new album, "Distant Dystopia". Enjoy! A Scent Like Wolves Socials: Twitter: https://twitter.com/aslwofficial Instagram: https://www.instagram.com/aslwofficial/ Facebook: https://www.facebook.com/ascentlikewolves/ TikTok: https://www.tiktok.com/@aslwofficial Apple Music: https://music.apple.com/us/artist/a-scent-like-wolves/428805018 Spotify: https://open.spotify.com/artist/45MtkhYiPMUHwT4Wv7qBji Bandcamp: https://ascentlikewolves.bandcamp.com/ Website: https://www.aslwofficial.com/ Grab some GNP Merch!: https://goodnoisepodcast.creator-spring.com/ Check out the recording gear we use: https://www.amazon.com/shop/goodnoisepodcast Support the show on Patreon: https://www.patreon.com/goodnoisepodcast Good Noise Podcast Socials: Twitter: https://twitter.com/good_noise_cast Instagram: https://www.instagram.com/goodnoisepodcast/ Facebook: https://www.facebook.com/goodnoisepod Discord: https://discord.gg/nDAQKwT YouTube: https://www.youtube.com/channel/UCFHKPdUxxe1MaGNWoFtjoJA Spotify: https://open.spotify.com/show/04IMtdIrCIvbIr7g6ttZHi All other streaming platforms: https://linktr.ee/goodnoisepodcast Bandcamp: https://goodnoiserecords.bandcamp.com/

Welcome to a brand new episode of Ian's Untitled Scene Show! In this episode, we welcome back the great Al Boltz of A Scent Like Wolves! Al returns, once again, to talk everything A Scent Like Wolves, early 2000s screamo/post-hardcore scene music, and so much more! PLUS, A Scent Like Wolves' brand new full-length album, ‘Distant Dystopia,' is out RIGHT NOW, through Theoria Records! I bet we discuss that in-depth as well…Prepare for a great catch-up episode with a lot of insight into A Scent Like Wolves and the scene!Note: Al is feeling a bit sick and Ian lost his voice earlier in the week, so nothing is perfect, haha.Check out the exclusive interview below, including iTunes, Spotify, and more:Spotify

How do you transform a high-stress law firm into a culture of balance and shared values? In this refreshing episode, we engage with Brooke Boltz, an accomplished attorney who specializes in injury and insurance law. Brooke candidly shares her journey from working at a firm with a high-demand culture to founding her own firm where she prioritizes work-life balance, employee well-being, and the integration of faith into her business practices. Join us as our host Nicole Jansen and Brooke Boltz discuss how to create a business environment that values not just productivity, but also the personal happiness and fulfillment of its employees. They talk about the impact of firm culture on profitability, stress management, and employee retention, and how faith can play a role in guiding a company's ethos. Discover the actionable steps Brooke took to pivot her business approach, her strategies for time management, and her initiatives to foster community among Christian entrepreneurs through her Facebook groups and top-performing podcast, the Ms. Biz Podcast. What We Discuss in this Episode Brooke's unexpected career path to injury and insurance law. The significance of work-life balance and faith in personal and professional life. Strategies for achieving a humane and employee-centric workplace. The advantages of Christian-based businesses and faith-driven decision-making. Building unity and community among Christians in the business world. Tips on maintaining employee satisfaction and retention through workplace culture. Insights into managing a successful multi seven-figure business and personal commitments. The effects of legislative changes on law firm profitability and adaptation strategies. How blending personal values with business can offer unique challenges and rewards. Managing increased responsibilities, delegation, and effective prioritization. Podcast Highlights 0:00 - Unexpected Career Paths: From Criminal Law to Injury and Insurance 5:15 - Work-Life Balance: Making Time for What Matters 7:30 - Faith in Business: The Foundation of Success 9:55 - Employee Motivation: Recognition and Rewards 12:40 - "Jesus Tribe": Fostering Community Among Christians 17:00 - Legal Landscape: Adaptation in the Face of Change 19:25 - Delegation Mastery: Brooke's Approach to Workload Management 22:30 - Corporate Culture and Faith: Integrating Personal Values 24:50 - A Discussion on Firm Culture Transformation 29:15 - Ms. Biz Podcast and Contributions to Nonprofits Dive deep into the conversation as Brooke Boltz shares her experiences and strategies on fostering a transformative and fulfilling business culture. Episode Show Notes: https://leadersoftransformation.com/podcast/business/483-faith-law-leadership-redefining-success-with-brooke-boltz  Check out our complete library of episodes and other leadership resources here: https://leadersoftransformation.com ________

Mark “Murch” Erhardt and Mike Schmidt are joined by Gloria Zhao, callebtc, Chris Stewart, Fabian Jahr, and Pierre Corbin to discuss ⁠Newsletter #290⁠. News DNS-based human-readable Bitcoin payment instructions (1:41) Thinking about mempool incentive compatibility (9:50) Cashu and other ecash system design discussion (29:15) Continued discussion about 64-bit arithmetic and `OP_INOUT_AMOUNT` opcode (39:52) Improved reproducible ASMap creation process (49:17) Changes to services and client software Multiparty coordination protocol NWC announced (1:11:00) Mutiny Wallet v0.5.7 released (1:19:07) GroupHug transaction batching service (1:19:48) Boltz announces taproot swaps (1:22:43) Releases and release candidates Core Lightning 24.02rc1 (1:24:07) Notable code and documentation changes Bitcoin Core #27877 (1:24:58) BOLTs #851 (1:29:00)

Moving from chain to chain is a pain in the ass. Layer on custodian risk and this area is ripe for better solutions. That was Boltz is working on with their non-custodial cross-chain/multi-layer swaps from different Bitcoin focued chains. Kilian is the co-founder of Boltz. We discuss: - How he got into Bitcoin? - The benefits of building things non-custodial - Using L2s to solve Lightning scaling problems and much more! Follow Kilian on Twitter: @kilrau Check out Boltz at https://boltz.exchange/

Meet

Meet

Pre-Show At least one person is living on bitcoin (https://blog.bitmex.com/getting-paid-in-btc-in-sin/) in Singapore, all you need is a master's in finance and higher income than expenses News Warren Expands Coalition of Banking Committee Support for Bill Cracking Down on Crypto's Use in Money Laundering, Drug Trafficking, Sanctions Evasion | U.S. Senator Elizabeth Warren of Massachusetts (https://www.warren.senate.gov/newsroom/press-releases/warren-expands-coalition-of-banking-committee-support-for-bill-cracking-down-on-cryptos-use-in-money-laundering-drug-trafficking-sanctions-evasion) Cosponsors - S.2669 - 118th Congress (2023-2024): Digital Asset Anti-Money Laundering Act of 2023 | Congress.gov | Library of Congress (https://www.congress.gov/bill/118th-congress/senate-bill/2669/cosponsors?s=1&r=19&overview=closed) Economics Arthur Hayes thinks that China and the US (https://cryptohayes.substack.com/p/panda-power) will coordinate a weak dollar policy to help China grow and the Democratic party win the 2024 election Bitcoin And Crypto To Be Measured At Fair Value Under New FASB Rules | Nasdaq (https://www.nasdaq.com/articles/bitcoin-and-crypto-to-be-measured-at-fair-value-under-new-fasb-rules) Bitcoin to be recorded at fair value under new FASB rules issued toda (https://twitter.com/BTC_Archive/status/1734954990165275103) Why is the EU supporing a French bank backed Euro stablecoin (https://amycastor.com/2023/12/09/societe-generales-useless-euro-stablecoin-when-bank-blockchain-units-go-feral/)? It's dollarization fears Privacy US Mass surveillance is increasing House Intel Committee Approves FISA Reform and Reauthorization Act of 2023 | Permanent Select Committee On Intelligence (https://archive.ph/n1vSs#selection-412.0-412.1) A 'broadening' of the term “electronic service communications provider” means that every wifi network (https://threadreaderapp.com/thread/1734249938333167889.html?ref=nobsbitcoin.com) or business in the USA will need to give the government your data without a warrant (https://www.nobsbitcoin.com/house-intelligence-committees-section-702-reform-bill-marks-the-biggest-expansion-of-surveillance-in-united-states-since-the-patriot-act/) Even a former FISA judge is alarmed at this overreach (https://www.zwillgen.com/law-enforcement/fisa-reform-bill-702-surveillance/) The EFF is on alert (https://www.eff.org/deeplinks/2023/12/section-702-needs-reform-and-oversight-not-expansion-congress-should-oppose-hpsci?ref=nobsbitcoin.com) Even IT industry publications like the Register (https://www.theregister.com/2023/12/14/congress_renews_fisa_section_702/) are reporting on this privacy monstrosity Is late stage liberalism when democratic state become de-facto authoritarian (https://podverse.fm/episode/loEoeZR1R) by ignoring the political ramifications of wealth? Ledger Wallet is a surveillance application (https://www.nobsbitcoin.com/ledger-live-tracks-and-sends-out-all-user-information-by-default/) and they have had their fragile cloud infrastructure compromised do not use ledger or their dApp ecosystem (https://twitter.com/MatthewLilley/status/1735285684070461534?t=Dn4QkFt9jP0QOTc0VW2S2A) "FINAL TIMELINE AND UPDATE TO CUSTOMERS" (https://twitter.com/Ledger/status/1735326240658100414) Ledger Connect Kit Exploited (https://www.nobsbitcoin.com/ledger-connect-kit-exploited/) Bitcoin Education Bitcoin Optech mentions another stratum V2 mining pool (https://bitcoinops.org/en/newsletters/2023/12/13/) launch More developments on ecash wallet recovery (https://www.nobsbitcoin.com/minibits-v0-1-5-beta/), interesting technology but difficult legally Feedback Remember to get in touch bitcoindadpod@protonmail.com or @bitcoindadpod (https://mobile.twitter.com/bitcoindadpod) on twitter Consider joining the matrix channel (https://matrix.to/#/#bitcoin:jupiterbroadcasting.com) using a matrix client like element (https://element.io/get-started), details here (https://www.jupiterbroadcasting.com/community/matrix/) Boosts From: @meremortalspodcast Through the podcast and I've recently got the opportunity to convert from lightning to onchain. 2 questions. How traceable are these sats from lightning (considering they come via a very identifiable Alby wallet)? And do you know many stories of people having non-KYC BTC who actually needed them? I know theoretically why non-KYC is important, but I'll be more persuaded with real life examples of where they were vital for economic freedom. reply on: I'm Kilian, Co-Founder of Boltz. AMA. stacker news ~bitcoin (https://stacker.news/items/339218) Thank you Boosters If you get some value from this show, please consider sending a boost. Hearing from you means a lot to us! Send a Boost via the Podcast Index web page. No Podcast app upgrade required. Install Alby (https://getalby.com/) Find the Bitcoin Dad Pod on the Podcast Index (https://podcastindex.org/podcast/5049889) Boost right from the page! Send a re-ocurring or one-off lightning boost to the show with no message at bdadpod@getalby.com or directly to Chris at chrislas@getalby.com Value for Value Podcasting 2.0 to support an indepenent podcasting ecosystem (https://podcastindex.org/) Recomended Podcasting2.0 apps: Fountain (https://www.fountain.fm/) podcast app (Android) Podverse (https://podverse.fm/) (Cross platform and self hostable) + Alby (https://getalby.com/) for boosts Castamatic (https://apps.apple.com/us/app/castamatic-podcast-player/id966632553) (Apple) Sponsors and Acknowledgements Music by Lesfm from Pixabay Self Hosted Show (https://selfhosted.show/) courtesy of Jupiter Broadcasting (https://www.jupiterbroadcasting.com/)

Follow Lisa Follow Base58Follow Bitcoin++Follow Jesse

As Only7Seconds has heavily shifted our focus to youth, we wanted to bring on one of our partners to share a perspective on why youth belonging is critical to making change in the youth loneliness epidemic. Our guest today is Erich Boltz from The Center For Educational Effectiveness (CEE). CEE develops and delivers quality surveys, data tools and services that catalyze community, district, school, and individual growth. For more on this collaborative conversation, our team joined CEE on their podcast, you can listen to Eric Driessen & Luke Wall chat with the CEE team here. Learn more about CEE and the work they do at www.effectiveness.org — Learn more about ⁠⁠Only7Seconds⁠⁠ Connect with us on social media: ⁠⁠Instagram⁠⁠ | ⁠⁠Facebook⁠⁠ | ⁠⁠Twitter⁠⁠ | ⁠⁠LinkedIn⁠⁠ — Music written & produced: ⁠⁠Dash8 --- Send in a voice message: https://podcasters.spotify.com/pod/show/only7seconds/message

Welcome back to the regularly scheduled 2nd Opinion Podcast! Things have been rough these past few weeks, with the holidays upon us things have been getting crazier every day! We plan on setting up a lot of content for the future, including interviews, bringing back our Head2Head segment, as well as having our co-host rejoin the show! We hope you enjoy this episode of the podcast and please make sure to subscribe! “In this audio episode, Caleb “Soleb” Gayle and Boltz discuss some of the latest gaming information and talk about their top games of 2023! “LIFE A BITCH, HOW ABOUT YOU?” Show introduction, this used to be called “what you've been drinking and gaming” but …who has time for that now? "THE GAME AWARDS Best Reveals, Worst Snubs, and other Bullshit" SOLEB and Boltz discuss The Game Awards 2023 and why it was exciting but a big let down as well! "END SHOW" --- Send in a voice message: https://podcasters.spotify.com/pod/show/2ndopinionpodcast/message

Join Car and Keyan to discuss Stacker News' top posts of the week, Car & Keyan's favorite posts of the week, and top stackers for the week of Dec 8th, 2023.Time stamps:04:11 - Find Your Co-Founder/Building Partner on Stacker News!08:33 - Lightning Prediction Market MVP - delphi.market11:05 - Stacker News Privacy Directory V1 - Q4 202313:11 - Multiplication in Bitvm16:26 - What's really scarce in BTC?18:30 - I'm Kilian, Co-Founder of Boltz. AMA.20:30 - SN release: territories, formerly known as user-generated subs24:56 - I stacked 40Thousand Sats On Stacker News More Than My Entire Life On Twitter27:18 - Stacker SaloonShoutout @Wumbo for time stamps. Zap em!Stacker News Live WebsiteThriller Bitcoin SN NewsletterZap us on Zap.StreamPlease find us streaming on YouTube & Twitter & NostrStacker News Live WebsiteThriller Bitcoin SN NewsletterZap us on Zap.StreamPlease find us streaming on YouTube & Twitter & NostrWe love the Fountain app for Lightning 2.0 podcastingSend us a Boost, and we will read it on the next SNLFind Car on NostrFollow Car on SNFollow Thriller on NostrFollow Thriller on TwitterFollow Thriller on YouTubeContribute to ~buildersLearn more about PlebLabFollow Keyan on TwitterFollow Keyan on NostrFollow Keyan on SNFollow Stacker News on NostrLearn more about Stacker News

Welcome back to the regularly scheduled 2nd Opinion Podcast! Things have been rough these past few weeks, with the holidays upon us things have been getting crazier every day! We plan on setting up a lot of content for the future, including interviews, bringing back our Head2Head segment, as well as having our co-host rejoin the show! We hope you enjoy this episode of the podcast and please make sure to subscribe! “In this audio episode, Caleb “Soleb” Gayle and Boltz discuss some of the latest gaming information and talk about their top games of 2023! “LIFE A BITCH, HOW ABOUT YOU?” Show introduction, this used to be called “what you've been drinking and gaming” but …who has time for that now? "THE GAME AWARDS? HOW ABOUT 2ND OPINIONS BEST GAMES OF 2023!?" SOLEB and Boltz discuss their top games of 2023 as well as mentioning their Honorable Mention Titles! "END SHOW" --- Send in a voice message: https://podcasters.spotify.com/pod/show/2ndopinionpodcast/message

Welcome to another episode of the "Just DeW It" podcast! In this episode, Anne Duffy has two incredible guests joining us, Susan Cotten and Kristie Boltz, who are passionate advocates for their respective charities. Susan will share her inspiring journey of fundraising for "Fire relief for Maui and Lahaina Dental Community," highlighting the critical work being done to aid those affected by fires in Maui. She'll delve into the personal connections that drive her commitment to this cause and how you can get involved in making a difference. Our second guest, Kristie Boltz, will open up about her involvement with the "Challenged Athletes Foundation (CAF)". Kristie is a staunch supporter of adaptive sports and will discuss the transformative impact that CAF has on athletes with physical challenges, as well as why it's such a meaningful cause to her. These two charities, "Fire relief for Maui and Lahaina Dental Community" and "Challenged Athletes Foundation," are not only close to Susan and Kristie's hearts but are also top donation choices for our 2023 DeW Good Fund. Tune in to learn more about these remarkable causes and how you can help raise awareness and make a positive impact today! Fire relief for Maui and Lahaina Dental Community Fund: https://www.gofundme.com/f/fire-relief-Maui-dental-community Get Involved with the Challenged Athletes Foundation (CAF): https://www.challengedathletes.org/get-involved/ Just DeW It Podcast is the official podcast of Dental Entrepreneur Women (DeW), founded by Anne Duffy, RDH. The mission of DeW is to inspire, highlight, empower, and connect all women in dentistry. To join the movement or to learn more, please visit dew.life. Together, we can DeW amazing things! Join the DeW Life movement by becoming a member using this link.Join the Dental Entrepreneur movement by becoming a member using this link.Read the most recent edition of DeW Life Magazine here. References: Dew Good Fund Dental Hygiene Program: University of Hawaii Leanne Higa Rosie Vierra Cindy Ishimoto Elijah Desmond Dentistry's Got Talent Dental Festival Mark LeBlanc Janet Hagerman Jim MacLaren Zoom

Our guest this week is Nate Boltz of Anchorage, AK who is executive director at Challenge Alaska and father of two, including one with Spina Bifida.Nate and his wife, Leah, have been married for 20 years and are the proud parents of two: Adeline (5) and Anna (16) who has Spina Bifida.Born in Bozeman, MT and raised in Fairbanks and Anchorage, Nate has always enjoyed the outdoors and athletics, including: skiing, hiking and endurance sports. Challenge Alaska is a non-profit dedicated to adaptive athletics and therapeutic recreation. Leah is also co-founder of Parks for All, a non-profit that designs and builds playgrounds that emphasize accessibility and inclusion, which has spread across the state of Alaska. We also learn about a range of other organizations, including: Equate Assist Therapy Alaska, Move United Association Therapeutics, Stay Focused and the National Ability Center. It's an uplifting story about strong family values, a love of athletics, merged with inclusion, acceptance and service to the community all on this episode of the Special Fathers Network Dad to Dad Podcast.Show LinksEmail – Nate@challengealaska.orgWebsite - https://www.challengealaska.org/Phone – 907-344-7399LinkedIn – https://www.linkedin.com/in/nate-boltz-11a92137/Parks For All – https://www.facebook.com/parksforall/Stay Focused – https://stay-focused.org/Move United - https://moveunitedsport.org/Program for Infants and Children - https://www.picak.org/home Special Fathers Network - SFN is a dad to dad mentoring program for fathers raising children with special needs. Many of the 500+ SFN Mentor Fathers, who are raising kids with special needs, have said: "I wish there was something like this when we first received our child's diagnosis. I felt so isolated. There was no one within my family, at work, at church or within my friend group who understood or could relate to what I was going through."SFN Mentor Fathers share their experiences with younger dads closer to the beginning of their journey raising a child with the same or similar special needs. The SFN Mentor Fathers do NOT offer legal or medical advice, that is what lawyers and doctors do. They simply share their experiences and how they have made the most of challenging situations.Check out the 21CD YouTube Channel with dozens of videos on topics relevant to dads raising children with special needs - https://www.youtube.com/channe... Please support the SFN. Click here to donate: https://21stcenturydads.org/do...Special Fathers Network: https://21stcenturydads.org/SFN Dads Mastermind Group - https://21stcenturydads.org/sfn-mastermind-group/Discover more about the Dads Honor Ride 2023 - https://21stcenturydads.org/2023-dads-honor-ride/Find out about Horizon Therapeutics – Science and Compassion Working Together To Transform Lives. https://www.horizontherapeutics.com/

They call her Mrs. Macros as Henem:1) Owns a macro-based meal plan company here in Bali (Macro Kitchen)2) Consistently and easily hits her macros to support her performance and her incredible shapeIn this episode, Henem and I discuss the ins and outs of all things Macros, meal planning, performance, aesthetics, lifestyle factors, and so much more. You will learn so much in this episode along with tangible tips and stories from our experiences with our own journeys and working with so many clients. Hemem's Bio:Physiotherapist by trade converted to nutrition coach currently specializing in Performance nutrition, Co-founder of Macro Kitchen Bali, deeply in love with weightlifting, fitness freak, food lover,  Mom of 2 of Beya and Nyx and happy wife of Boltz.Work with Jenny the Nutritionist in Create Your Shape:https://jennythenutritionist.com/create-your-shape/Follow Jenny the Nutritionist on Instagram:@jennythenutritionist

Today I'm interviewing my personal trainer, Matt Boltz.  He's recently helped me recover from my injuries, regain strength, and feel like an athlete again.  We cover the 3 phase strategy for healing injuries, specific ways to use exercises to heal while still building strength, and how to combine physical therapy and strength training to work smarter. When we "Treat Rehab like Training" it becomes more fun and intentional.  This will be a beneficial episode for anyone who is injured, has nagging injuries, wants to improve performance or functionality for the long term, or wants to put preventative measures in place.  For all Create Your Shape current and alumni ladies, Matt has also been generous enough to offer a Free Pain-Free Performance Consultation call where he'll also provide a 21-day Pain-Free plan and follow-up. Click here to schedule with him. (Valid until Sept 6th 2023)Coach Boltz (The Body Mechanic) Bio:14 years strength and conditioning coach, ex-military, and PTI. Helping soldiers get fit for purpose and now helping people to build better bodies, cultivate more confidence, and rebound from injuries stronger, fitter, and faster!Work with Jenny the Nutritionist in Create Your Shape:https://jennythenutritionist.com/create-your-shape/Follow Jenny the Nutritionist on Instagram:@jennythenutritionist

Join Kathleen Darling as she hosts David de Boltz, Managing Director of Leveraged Finance Capital Markets, to discuss the tech sector's current financing activities and trends. They dive into drivers and challenges, from macroeconomic dynamics, institutional demand to the market technicals. Find out why tech financing is in a “Goldilocks” scenario, and how the resurgent M&A and AI wave could turn up the heat.  This episode was recorded on July 24, 2023. This material was prepared by certain personnel of JPMorgan Chase & Co. and its affiliates and subsidiaries worldwide and not the firm's research department. It is for informational purposes only, is not intended as an offer or solicitation for the purchase, sale or tender of any financial instrument and does not constitute a commitment, undertaking, offer or solicitation by any JPMorgan Chase entity to extend or arrange credit or to provide any other products or services to any person or entity. © 2023 JPMorgan Chase & Company. All rights reserved.

“In this audio episode, Caleb “Soleb” Gayle and Boltz discuss some of the latest gaming information as well as talk about Cloud gaming and The Xbox Buy-Out! “LIFE A BITCH, HOW ABOUT YOU?” Show introduction, this used to be called “what you've been drinking and gaming” but …who has time for that now? “Sony PlayStation needs to move on” “Bolts and Soleb will discuss the ongoing Xbox Activision Buy out and new developments in the case” https://gamerant.com/playstation-boss-jim-ryan-starfield-xbox-exclusivity-comments/ https://gamerant.com/xbox-game-pass-bad-playstation-jim-ryan/ https://www.kitguru.net/gaming/matthew-wilson/call-of-duty-almost-abandoned-xbox-this-generation/ https://www.gamingbible.com/news/xbox-spencer-whatever-it-takes-keep-franchise-playstation-335167-20230626 "RED DEAD REDEMPTION 1 REMASTER POSSIBLY COMING" “Bolts and Soleb will discuss the possibility of an RDR 1 remake and GTA6 Rumors" https://gamerant.com/rumor-red-dead-redemption-remaster-korean-rating/ “IT'S TIME FOR A 2ND OPINION” “Soleb and Bolts discuss the reality of Cloud gaming in a world that's still not fully online” MORTAL KOMBAT 1 STRESS TEST IMPRESSIONS! ENDING SHOW --- Send in a voice message: https://podcasters.spotify.com/pod/show/2ndopinionpodcast/message