Podcasts about seeg

Au Gabon, la popularité du président de la transition, le général Oligui Nguema, est-elle en train de s'effriter ? « Oui », affirmait hier notre invité, le syndicaliste Jean-Rémy Yama. « Non », répond ce matin François Ndong Obiang, qui est le premier vice-président de l'Assemblée nationale et qui affirme que 70 % des Gabonais soutiennent l'ancien officier putschiste du 30 août 2023. La présidentielle, c'est dans deux mois, le 12 avril, mais aucun poids lourd n'a encore annoncé sa candidature. Que fera le général Oligui Nguema ? De passage à Paris, le premier vice-président de la Chambre répond à Christophe Boisbouvier. RFI : On est à moins de deux mois de la présidentielle et le général Brice Oligui Nguema reste muet sur ses intentions. Est-ce à dire qu'il hésite à être candidat ? François Ndong Obiang : Non, je ne pense pas qu'il y ait d'hésitations. Nous sommes dans les temps. Je pense que s'il a la volonté et la détermination d'être candidat, il annoncera sa candidature dans les jours prochains. Je pense que d'ailleurs cette candidature est souhaitée par le peuple gabonais, parce qu'il a commencé quelque chose qui a été perçu comme un profond changement. Et donc vous pensez qu'il annoncera sa candidature d'ici à la fin de ce mois de février ? Oui, nous sommes à deux mois, nous sommes le 14 février aujourd'hui, il faudra effectivement que, dans les jours qui viennent, monsieur Oligui se prononce sur sa candidature. Alors vous-même, François Ndong Obiang, vous avez appelé à voter « oui » à la nouvelle Constitution, c'était au mois de novembre dernier. Vous êtes député, premier vice-président de l'Assemblée nationale, est-ce que vous soutiendrez son éventuelle candidature ? Oui, nous partageons cette vision. Nous partageons une vision de tranquillité, une vision de prospérité et une vision de rupture apaisée. Vous savez, le Gabon vit une transition spécifique où il n'y a pas eu d'emprisonnement et de chasse aux sorcières, et où le chronogramme qui a été arrêté en septembre 2023 est suivi et respecté. Donc, si nous marchons dans cette voie, je suis prêt à continuer à soutenir cette logique et probablement la candidature de monsieur Oligui quand il se prononcera. Voilà 18 mois que le général Oligui préside la transition. Alors, juste après le putsch, il était très populaire. Mais aujourd'hui, avec les difficultés de la vie quotidienne, avec les pannes d'électricité qui sont nombreuses en ce moment à Libreville, est-ce que vous ne craignez pas que cette popularité s'effondre ?Elle ne peut pas s'effondrer en deçà de 50 % de l'électorat gabonais. Je peux reconnaître effectivement tous les dysfonctionnements sur la SEEG [la société d'électricité - NDLR] qui sont dramatiques, qui sont pénibles pour tous les Gabonais. C'est vrai. Encore que ces problèmes soient là depuis longtemps, la société n'a pas été restructurée. Bon, mais même le bon Dieu a des contradicteurs. Donc, Oligui Nguema, légitimement, devrait avoir des contradicteurs, mais sa popularité ne peut pas être en deçà de 70 % aujourd'hui. On ne peut pas tout faire maintenant, mais ce qui se fait au moins est visible et apprécié par les Gabonais. Donc oui, il peut y avoir des dysfonctionnements avec le courant et l'eau, mais on va réparer tout cela.  À lire aussiAu Gabon, la population vit au rythme des délestages d'électricitéÀ la présidentielle d'août 2023, François Ndong Obiang, vous étiez le président de la plateforme Alternance 2023 et donc le premier soutien du candidat Albert Ondo Ossa contre le parti au pouvoir PDG et son candidat Ali Bongo. Or, aujourd'hui, vous êtes aux côtés du PDG pour soutenir le probable candidat Brice Clotaire Oligui Nguema. Pourquoi cette volte-face ?Oh, ce n'est pas une volte-face. Moi, je suis sur mes convictions. Moi, je ne suis pas PDGiste, et je crois que je ne l'ai pas été et que je ne le serai jamais. Mais, par conséquent, on peut avoir des acteurs de ce parti qui sont des hommes convenables et respectables. Donc, si le PDG soutient le candidat Oligui, c'est leur affaire, mais moi, je ne suis pas dans la logique du PDG. Moi, je soutiendrai le candidat Oligui parce que je sais que c'est un homme authentique dont on ne recherche pas l'acte de naissance pendant six jours, qui a une trajectoire scolaire établie et qui a un père et une mère qui sont visibles.À la différence d'Ali Bongo, en fait ?Je ne vous le fais pas dire... Donc, je soutiendrai Oligui pour la vision du bâtisseur qu'il a. Il ne sera pas le candidat du PDG.Au vu des conditions très restrictives de la Charte de la transition et du Code électoral, il y a très peu de figures politiques gabonaises qui seront éligibles ce 12 avril. Est-ce que vous ne craignez pas que le général Oligui se retrouve tout seul comme candidat de poids face à simplement deux ou trois figurants ?Mais il faut justement qu'Oligui ait des candidats contre lui. Il faut que l'élection soit ouverte, sinon on va proclamer autre chose. Bon, attendons voir.Hier, on a entendu sur RFI le syndicaliste Jean-Rémy Yama qui vient de créer son parti et qui semble penser sérieusement à une candidature. Qu'est-ce que vous lui conseillez ? Je lui conseillerai simplement de garder et de conserver ses énergies et de participer à un mouvement collectif qui nous permettrait de capter toutes les capacités qu'il y a de bon dans ce pays pour avancer. Vous lui conseillez de rejoindre la future plateforme pour le candidat Oligui Nguema ?Mais oui, c'est un monsieur courageux. C'est un monsieur qui a souffert dans sa chair. Je pense qu'il ne serait pas bon qu'il se disperse. À lire aussiPrésidentielle au Gabon: «C'est un mauvais signal que le président Oligui soit le candidat du PDG»

In der 72. Folge des Originalteile-Podcasts gewährt Sven Seeg tiefe Einblicke in seine persönlichste Lebensphase. Mit entwaffnender Ehrlichkeit spricht er darüber, wie er als erfolgreiche Führungskraft 2019 in eine schwere Krise geriet und wie er ohne Medikamente seinen Weg zurück ins Leben fand. Ab Minute 48 nimmt Sven uns mit in seine dunkelsten Stunden: Die schlaflosen Nächte, die körperlichen Beschwerden, das Gedankenkarussell, das nicht aufhören wollte. Er beschreibt eindrücklich den Moment, als nichts mehr ging und Sven mit der Malerrolle in der Hand nicht fähig war, das Zimmer seines Sohnes zu streichen - und wie dieser Tiefpunkt zum Wendepunkt wurde. Seine Geschichte macht Hoffnung und zeigt einen ungewöhnlichen Weg aus der Krise durch Meditation und bewusstes Atmen. Zu Beginn erzählt Sven auch von seiner Vergangenheit als Torwart beim VfR Heilbronn und VfB Stuttgart sowie seinem beruflichen Werdegang, nachdem der Traum vom Profifußball geplatzt war. Der Kern dieser Folge ist jedoch seine authentische Schilderung der Krisenbewältigung und wie er dadurch heute anderen Menschen helfen möchte. Erfahrt mehr über wirksame Techniken zur Stressbewältigung, die transformative Kraft der Meditation und warum manchmal der tiefste Punkt der Beginn von etwas Neuem sein kann. Wenn du dich in einer ähnlichen Situation befindest wie Sven damals, wenn du jemanden kennst, der gerade durch eine Krise geht, oder wenn du einfach präventiv etwas für deine mentale Gesundheit tun möchtest: Zögere nicht, mit Sven Kontakt aufzunehmen. Er steht dir als Ansprechpartner zur Verfügung - per Mail unter kontakt@innerer-anker.de oder über sein LinkedIn-Profil: https://www.linkedin.com/in/sven-seeg-556317237/. Manchmal ist der erste Schritt der schwerste, aber wie Svens Geschichte zeigt: Es gibt einen Weg aus der Krise. Audio: Philipp Seitz (www.philipp-seitz.de) Werbung wegen Namensnennung Unterstützer und Möglichmacher ist das Autozentrum Hagelauer als Premium-Freund dieses Podcasts! Neuwagen und Elektromobilität vom #HeilbronnerOriginal gibt's hier: www.hagelauer.de Infos zu den neuen Fahrrädern: www.bhbikes.com/de_DE #mentalhealth #achtsamkeit #meditation #burnout #podcast #atmen #originalteile #torwart #selbstfindung #stressbewältigung #heilbronn

Die Menschen in der kleinen Gemeinde Seeg im Ostallgäu sind die Hängepartie Leid, ihr Ort kommt nicht zur Ruhe: Vor mehr als eineinhalb Jahren wurde der Bürgermeister der Gemeinde verhaftet. Ein Neustart in Seeg ist auch nach mehr als eineinhalb Jahren nicht möglich. Die Gemeinde hängt weiter in der Luft. Ein Szenario, das auch andernorts denkbar wäre.

Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice. In this episode, epilepsy expert Imad Najm, MD, PhD, sat down to discuss the upcoming Cleveland Clinic Epilepsy Summit, an educational symposium that takes place September 11-15, in Cleveland, Ohio. Najm, who serves as the director of Cleveland Clinic's Epilepsy Center at the Cleveland Clinic Neurological Institute, spoke about the objectives and goals of the meeting, including updates on sEEG, epilepsy surgery, treatments for drug-resistant epilepsy, and gene therapy. In addition, he provided an overview of the latest advances in epilepsy surgery, genetics, and seizure controlling approaches. Furthermore, he spoke on some of the educational challenges with adjusting to changes in neurosurgery, the potential benefits and limitations of gene therapy, and the future of epilepsy treatment.  Looking for more Epilepsy discussion? Check out the NeurologyLive® Epilepsy clinical focus page. Episode Breakdown: 1:10 – Mission and goals of Epilepsy Summit  3:05 – Overviewing sessions and educational attainment 4:55 – Changes to epilepsy surgery, advances over the years 9:15 – Neurology News Minute 11:50 – Learning curve for understanding new epilepsy surgery tactics 13:50 – Closing thoughts on the upcoming meeting 15:50 – Potential benefits and challenges to gene therapy for epilepsy The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: EMA Accepts Marketing Authorization Application for Huntington Disease Agent Pridopidine BTK Inhibitor Tolebrutinib Slows Disability Progression in Phase 3 HERCULES Study of Non-Relapsing Secondary Progressive MS FDA Accepts Resubmitted New Drug Application for Migraine Treatment AXS-07 Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.

Have you ever wondered if it's possible to give speech back to those who've lost it using advanced brain technology? Dear Listeners, welcome to episode #82 of our “Neurocareers: Doing the Impossible!” podcast, where we're diving deep into the world of speech neuroprostheses and exploring how brain-computer interfaces (BCIs) are unlocking new ways to communicate. Speech-decoding BCIs are gaining ground rapidly. They promise a new way to communicate for those who cannot speak by tapping directly into brain activity. The secret to making these devices work is understanding how speech is produced in the brain, from the timing to the specific brain regions involved. Interestingly, it looks like even deeper brain areas, including the insula, hippocampus, and thalamus are involved in this process. I am your podcast host Dr. Milena Korostenskaja or simply Dr. K. and joining us today is Maxime Verwoert, a researcher with the long-term goal of developing speech neuroprostheses. After her studies in Psychology and Neuroscience at Utrecht University, Maxime is now a PhD candidate at Maastricht University in Netherlands focusing on decoding speech signals in real-time with stereo-EEG. This technology is less invasive than other methods, such as ECoG, offering hope for long-term use in BCIs. Maxime's recent work, published in Nature's Scientific Data, involved collecting a rich dataset from participants reading aloud while their brain activity was meticulously recorded. This dataset covers a broad spectrum of brain regions and offers deep insights into how we produce speech. In our chat, Maxime explains how this cutting-edge technology is developed, the hurdles of interpreting complex brain signals into speech, and what the future holds for people needing speech neuroprostheses. Maxime will also share her advice for those who are planning to get into the field of neurotechnologies. Whether you're a tech enthusiast, a healthcare professional, or just curious about how neuroscience changes lives, this conversation promises to bring unique knowledge and inspiration. So tune in, and get ready to be amazed by how close we are to turning thoughts into words! About the Podcast Guest: Get in touch with Maxime Verwoert via LinkedIn: https://www.linkedin.com/in/maxime-verwoert-756966105/ Lab:  https://neuralinterfacinglab.github.io/ Dataset: https://osf.io/nrgx6/ https://www.nature.com/articles/s41597-022-01542-9 Articles: https://doi.org/10.3389/fnins.2020.00123 (sEEG for BCIs) https://ieeexplore.ieee.org/document/10394550 (sEEG semantics) https://www.nature.com/articles/s42003-021-02578-0 (sEEG speech BCI proof-of-concept) https://doi.org/10.1007/s13311-022-01190-2 (speech BCI review)  Courses: https://www.codecademy.com/ https://www.codecademy.com/ https://www.coursera.org/ https://scikit-learn.org/stable/  https://neuromatch.io/ Mental Health: “Feeling Great” Book (https://www.amazon.com/stores/page/E0B7C5D5-CD14-405B-BD0A-253F8D94A3B4?channel=db-website) “Feeling Good” Podcast (https://feelinggood.com/subscribe/)   About the Podcast Host: The Neurocareers podcast is brought to you by The Institute of Neuroapproaches (https://www.neuroapproaches.org/) and its founder, Milena Korostenskaja, Ph.D. (Dr. K), a neuroscience educator, research consultant, and career coach for people in neuroscience and neurotechnologies. As a professional coach with a background in the field, Dr. K understands the unique challenges and opportunities job applicants face in this field and can provide personalized coaching and support to help you succeed. Here's what you'll get with one-on-one coaching sessions from Dr. K: Identification and pursuit of career goals Guidance on job search strategies, resume, and cover letter development Neurotech / neuroscience job interview preparation and practice Networking strategies to connect with professionals in the field of neuroscience and neurotechnologies Ongoing support and guidance to help you stay on track and achieve your goals You can always schedule a free neurocareer consultation/coaching session with Dr. K at https://neuroapproaches.as.me/free-neurocareer-consultation Subscribe to our Nerocareers Newsletter to stay on top of all our cool neurocareers news at updates https://www.neuroapproaches.org/neurocareers-news   

Se você acompanha esse podcast, sabe que aqui a gente discute as tecnologias, os incentivos e as políticas públicas para descarbonizar os vários setores da economia. Esse é um processo complexo, que envolve cadeias inteiras de produção e que coloca em xeque as fontes de energia fóssil, das quais o mundo ainda depende. Mas no Brasil essa história é um pouco diferente. Claro que que o país também precisa deixar o petróleo, o carvão e o gás natural no passado. E claro que várias atividades econômicas precisam ser redesenhadas. Mas no Brasil o mais importante mesmo é acabar com o desmatamento e mudar a forma como criamos gado. É por isso que eu achei particularmente interessante um estudo recente da ong Observatório do Clima. O projeto SEEG, Sistema de Estimativas de Emissões de Gases de Efeito Estufa, identificou que sozinho, o setor de alimentos respondeu por mais de 70% das emissões de gases do efeito estufa do Brasil em 2021. Só para você ter uma ideia, globalmente, o impacto dos alimentos não passa de 30%. Isso reflete a forma como a comida é produzida no país: o que inclui a destruição de florestas e uma pecuária pouco adaptada à realidade climática.Nesse episódio eu converso com David Tsai, coordenador do projeto SEEG do Observatório do Clima. Ele explica como desmatamento, bois e aquecimento global estão conectados. Nós também falamos do que precisa ser feito para tirar o setor de alimentos da posição de vilão - especialmente diante do aumento da população global e do papel do Brasil como grande exportador de commodities agrícolas. Support the show

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.26.546582v1?rss=1 Authors: Stieger, J., Pinheiro-Chagas, P., Fang, Y., Lusk, Z., Perry, C., Wagner, A. D., Contreras, D., Chen, Q., Huguenard, J., Buch, V., Parvizi, J. Abstract: For the human mind to operate, populations of neurons across remote regions of the brain need to coordinate their activity in the subsecond temporal scale. To date, our knowledge of such fast interactions involving cortical and subcortical structures in large brains, such as the human brain, remains limited. Here, we used stereo-electroencephalography (sEEG) recordings across four brain regions that are known, from decades of work, to be important for autobiographical memory processing. Our recordings involved 31 human participants implanted with intracranial electrodes in the hippocampus (HPC), posteromedial cortex (PMC), and ventromedial, as well as orbital subregions of the prefrontal cortex (OFC). In 14 subjects, we also recorded simultaneously in the anterior thalamus (ANT) across various experimental conditions and with direct electrical stimulations. Our observations provide new lines of correlative and causal evidence about the spatiotemporal profile of oscillatory coordination of cortical and subcortical activity during self-referential memory-based processing. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.31.535153v1?rss=1 Authors: Koenig, S. D., Safo, S., Miller, K. J., Herman, A. B., Darrow, D. P. Abstract: Background: Time series analysis is critical for understanding brain signals and their relationship to behavior and cognition. Cluster-based permutation tests (CBPT) are commonly used to analyze a variety of electrophysiological signals including EEG, MEG, ECoG, and sEEG data without a priori assumptions about specific temporal effects. However, two major limitations of CBPT include the inability to directly analyze experiments with multiple fixed effects and the inability to account for random effects (e.g. variability across subjects). Here, we propose a flexible multi-step hypothesis testing strategy using CBPT with Linear Mixed Effects Models (LMEs) and Generalized Linear Mixed Effects Models (GLMEs) that can be applied to a wide range of experimental designs and data types. Methods: We first evaluate the statistical robustness of LMEs and GLMEs using simulated data distributions. Second, we apply a multi-step hypothesis testing strategy to analyze ERPs and broadband power signals extracted from human ECoG recordings collected during a simple image viewing experiment with image category and novelty as fixed effects. Third, we assess the statistical power differences between analyzing signals with CBPT using LMEs compared to CBPT using separate t-tests run on each fixed effect through simulations that emulate broadband power signals. Finally, we apply CBPT using GLMEs to high-gamma burst data to demonstrate the extension of the proposed method to the analysis of nonlinear data. Results: First, we found that LMEs and GLMEs are robust statistical models. In simple simulations LMEs produced highly congruent results with other appropriately applied linear statistical models, but LMEs outperformed many linear statistical models in the analysis of suboptimal data and maintained power better than analyzing individual fixed effects with separate t-tests. GLMEs also performed similarly to other nonlinear statistical models. Second, in real world human ECoG data, LMEs performed at least as well as separate t-tests when applied to predefined time windows or when used in conjunction with CBPT. Additionally, fixed effects time courses extracted with CBPT using LMEs from group-level models of pseudo-populations replicated latency effects found in individual category-selective channels. Third, analysis of simulated broadband power signals demonstrated that CBPT using LMEs was superior to CBPT using separate t-tests in identifying time windows with significant fixed effects especially for small effect sizes. Lastly, the analysis of high-gamma burst data using CBPT with GLMEs produced results consistent with CBPT using LMEs applied to broadband power data. Conclusions: We propose a general approach for statistical analysis of electrophysiological data using CBPT in conjunction with LMEs and GLMEs. We demonstrate that this method is robust for experiments with multiple fixed effects and applicable to the analysis of linear and nonlinear data. Our methodology maximizes the statistical power available in a dataset across multiple experimental variables while accounting for hierarchical random effects and controlling FWER across fixed effects. This approach substantially improves power and accuracy leading to better reproducibility. Additionally, CBPT using LMEs and GLMEs can be used to analyze individual channels or pseudo-population data for the comparison of functional or anatomical groups of data. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.27.534002v1?rss=1 Authors: Campbell, J. M., Davis, T. S., Nesterovich Anderson, D., Arain, A., Inman, C. S., Smith, E. H., Rolston, J. D. Abstract: Emerging evidence suggests that the temporal dynamics of cortico-cortical evoked potentials (CCEPs) may be used to characterize the patterns of information flow between and within brain networks. At present, however, the spatiotemporal dynamics of CCEP propagation cortically and subcortically are incompletely understood. We hypothesized that CCEPs propagate as an evoked traveling wave emanating from the site of stimulation. To elicit CCEPs, we applied single-pulse stimulation to stereoelectroencephalography (SEEG) electrodes implanted in 21 adult patients with intractable epilepsy. For each robust CCEP, we measured the timing of the maximal descent in evoked local field potentials and broadband high-gamma power (70-150 Hz) envelopes relative to the distance between the recording and stimulation contacts using three different metrics (i.e., Euclidean distance, path length, geodesic distance), representing direct, subcortical, and transcortical propagation, respectively. Many evoked responses to single-pulse electrical stimulation appear to propagate as traveling waves (~17-30%), even in the sparsely sampled, three-dimensional SEEG space. These results provide new insights into the spatiotemporal dynamics of CCEP propagation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Dr. Alexander Whiting is a neurosurgeon and director of epilepsy surgery for Allegheny Health Network's Neuroscience Institute. He specializes in state-of-the-art epilepsy treatments, including stereoelectroencephalography (SEEG), seizure focus resections, laser ablations, vagal nerve stimulation, and responsive neurostimulation. Additionally, he has clinical interests in complex spine and brain disorders, and offers a range of surgical options and interventions for these conditions. Dr. Whiting completed his residency at the Barrow Neurological Institute in Phoenix, Arizona. He completed his fellowship in epilepsy surgery at the Cleveland Clinic in Cleveland, Ohio, and was awarded the American Epilepsy Society's prestigious Young Investigator Award. Today we speak to Dr. Whiting about SEEG.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.13.523921v1?rss=1 Authors: Alonso, F., Mercadal, B., Salvador, R., Ruffini, G., Bartolomei, F., Wendling, F., Modolo, J. Abstract: Intracranial electrodes are used clinically for diagnostic or therapeutic purposes, notably in drug-refractory epilepsy (DRE) among others. Visualization and quantification of the energy delivered through such electrodes is key to understanding how the resulting electric fields modulate neuronal excitability, i.e. the ratio between excitation and inhibition. Quantifying the electric field induced by electrical stimulation in a patient-specific manner is challenging, because these electric fields depend on a number of factors: electrode trajectory with respect to folded brain anatomy, biophysical (electrical conductivity / permittivity) properties of brain tissue and stimulation parameters such as electrode contacts position and intensity. Here, we aimed to evaluate various biophysical models for characterizing the electric fields induced by electrical stimulation in DRE patients undergoing stereoelectroencephalography (SEEG) recordings in the context of pre-surgical evaluation. This stimulation was performed with multiple-contact intracranial electrodes used in routine clinical practice. We introduced realistic 3D models of electrode geometry and trajectory in the neocortex. For the electrodes, we compared point (0D) and line (1D) sources approximations. For brain tissue, we considered three configurations of increasing complexity: a 6-layer spherical model, a toy model with a sulcus representation, replicating results from previous approaches; and went beyond the state-of-the-art by using a realistic head model geometry. Electrode geometry influenced the electric field distribution at close distances (~3 mm) from the electrode axis. For larger distances, the volume conductor geometry and electrical conductivity dominated electric field distribution. These results are the first step towards accurate and computationally tractable patient-specific models of electric fields induced by neuromodulation and neurostimulation procedures. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.01.518775v1?rss=1 Authors: Wu, T. Q., Kaboodvand, N., Veit, M., McGinn, R. J., Davey, Z., Datta, A., Graber, K. D., Meador, K. J., Fisher, R., Buch, V., Parvizi, J. Abstract: Neuromodulation of the anterior nuclei of the thalamus (ANT) has shown to be efficacious in patients with refractory focal epilepsy, but it is not uniformly effective. One important uncertainty is to what extent thalamic subregions other than the ANT are recruited earlier and more prominently in the propagation of seizures in patients with presumed temporal lobe epilepsy (TLE). To address this unknown, we studied 11 patients with clinical manifestations of TLE planned to undergo invasive stereo-encephalography (sEEG) monitoring. We extended cortical electrodes to reach thalamic nuclear subdivisions in the anterior (ANT), middle (mediodorsal) and or posterior (pulvinar) sites. This multisite thalamic sampling was without any adverse events. Intracranial EEG (iEEG) recordings confirmed seizure onset in medial temporal lobe, insula, orbitofrontal and temporal neocortical sites, thereby highlighting the importance of iEEG for more accurate localization of seizure foci. Visual review of EEGs documented early and prominent involvement of specific thalamic sites. Seizures originating from the same brain origin produced a stereotyped thalamic EEG signature. Visual review of EEGs, validated with single-pulse corticothalamic evoked potentials, documented early and prominent involvement of thalamic sites that would have not been predicted given the anatomy of seizure onset zones. Pulvinar was involved earlier and more prominently than other sampled nuclear subgroups in 60% of patients, even though all patients had a presumed diagnosis of TLE prior to invasive monitoring. Our findings document the feasibility and safety of multisite sampling from the human thalamus and suggest that the anatomy of thalamic involvement may not be entirely predictable on the basis of clinical information or lobar localization of seizures. Future clinical trials can establish whether offering more personalized targets for thalamic neuromodulation will lead to greater meaningful improvements in outcome. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.24.517800v1?rss=1 Authors: Fusca, M., Siebenhuhner, F., Wang, S. H., Myrov, V., Arnulfo, G., Nobili, L., Palva, J. M., Palva, S. Abstract: Moderate levels of synchronization of neuronal oscillations are essential for healthy brain dynamics. Synchronization levels exhibit large inter-individual variability the origins of which are unknown. Neuronal systems have been postulated to operate near a critical transition point or in an extended regime between disorder (subcritical) and order (supercritical phase) characterized by moderate synchronization and emergent power-law long-range temporal correlations (LRTCs). We investigated whether inter-individual variability in synchronization levels is explained by the individual position along the critical regime by analyzing magnetoencephalography (MEG) and intra-cerebral stereo-electroencephalography (SEEG) human resting-state data. Here we show that variability in synchronization levels exhibits a positive linear and quadratic relationships with LRTCs in healthy participants and brain areas. In the epileptogenic zone this correlation was negative. These results show that variability in synchronization levels is regulated by the individual position along an extended critical-like regime, with healthy brain areas tending to operate in its subcritical and epileptogenic areas in its supercritical side. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.01.514655v1?rss=1 Authors: Haast, R. A., Testud, B., Makhalova, J., Dary, H., Cabane, A., Le Troter, A., Ranjeva, J.-P., Bartolomei, F., Guye, M. Abstract: Focal epilepsy is characterized by repeated spontaneous seizures that originate from one or multiple epileptogenic zones (EZ). These epileptic activities rapidly propagate to other regions in the brain following a hierarchical organization defined by a decrease in epileptogenicity and the anatomical specificity of subnetworks, also known as EZ networks (EZN). More recently, analysis of intracerebral recordings showed that subcortical structures, and in particular the thalamus, play an important role in facilitating and/or propagating epileptic activity. This supports previously reported structural alterations of these structures. Nonetheless, between-patient differences in EZN (e.g., temporal vs. non-temporal lobe epilepsy) as well as other clinical features (e.g., number of EZs) might impact the magnitude and spatial distribution of subcortical structural changes. Here we used 7 Tesla MRI T1 data to provide a comprehensive description of subcortical morphological (volume, tissue deformation, and shape) and longitudinal relaxation (T1) changes in focal epilepsy patients to evaluate the impact of the EZN and patient-specific clinical features. Our results revealed widespread morphometric alterations as well as reduction in T1, with volume acting as the dominant discriminator between patients and controls, while thalamic T1 measures looked promising to further differentiate patients based on EZN. In particular, the observed differences in T1 changes between thalamic nuclei indicated differential involvement of thalamic nuclei based on EZN. Finally, the number of EZs was found to best explain the observed variability between patients. To conclude, this work revealed multi-scale subcortical alterations in focal epilepsy as well their dependence on several clinical characteristics. Our results provide a basis for further, in-depth investigations using (quantitative) MRI and SEEG data and warrant further personalization of intervention strategies, such as deep brain stimulation, for treating focal epilepsy patients. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.11.511706v1?rss=1 Authors: Shih, W.-Y., Yu, H.-Y., Lee, C.-C., Chou, C.-C., Chen, C., Glimcher, P. W., Wu, S.-W. Abstract: During economic choice, evidence from monkeys and humans suggest that activity in the orbitofrontal cortex (OFC) encodes the subjective values of options under consideration. Monkey data further suggests that value representations in the OFC are context dependent, representing subjective value in a way influenced by the decision makers recent experience. Using stereo electroencephalography (sEEG) in human subjects, we investigated the neural representations of both past and present subjective values in the OFC, insula, cingulate and parietal cortices, amygdala, hippocampus and striatum. Patients with epilepsy (n=20) reported their willingness to pay, a measure of subjective value, for snack food items in a Becker-DeGroot-Marschack (BDM) auction task. We found that the high frequency power (gamma and high-gamma bands) in the OFC positively correlated with the current subjective value but negatively correlated with the subjective value of the good offered on the last trial, a kind of temporal context dependency not yet observed in humans. These representations were observed at both the group level (across electrode contacts and subjects) and at the level of individual contacts. Noticeably, the majority of significant contacts represented either the present or past subjective value, but not both. A dynamic dimensionality-reduction analysis of OFC population trajectories suggested that the past trial begin to influence activity early in the current trial after the current offer was revealed, and that these two properties, current and past subjective values, dominate the electrophysiological signals. Together, these findings indicate that information about the value of the past and present rewards are simultaneously represented in the human OFC, and offer insights into the algorithmic structure of context-dependent computation during human economic choice. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Tocsin is a noun that refers to an alarm bell or signal. Our word of the day combines the French word for ‘touch' with the Latin word signum (SEEG noom) which means ‘bell' or ‘signal.' Here's an example of tocsin in use: We should have realized those howls in the night were a tocsin of what was to come. If we had we'd have known there were bears in the area.

Eine Verletzte durch gerissenes Bungeeseil auf Straubinger Gäubodenvolksfest / Wie gehen Menschen in Bayern mit der neuen Gasumlage um? / Auswirkungen der steigenden Energiepreise auf einen Sportverein in Erlangen / European Championships in München bringen Erinnerungen an Olympia 1972 zurück / Fünf bayerische Städte erhalten die Landesgartenschauen von 2028 bis 2032 / Wegen Personalmangel muss eine Traditionsmetzgerei in Seeg im Ostallgäu schließen / Erntebilanz zeigt zweigeteiltes Bayern / Trockenheit macht Kirchenorgeln zu schaffen / Geldauflage für Pfarrer in Gundelfingen wegen Kirchenasyl / Musikmanager Hans R. Beierlein tot / Mysteriöses Gewaltverbrechen in Ingolstadt mit einer Doppelgängerin / Seeadler-Paar im Landkreis Dillingen hat Nachwuchs

Many patients with epilepsy can manage their seizures with medications and lifestyle changes. But for nearly one-third of patients with severe epilepsy, other treatment plans, including surgery, may be necessary.In this podcast, Stephen Schuele, MD, MPH, chief of Epilepsy and Neurophysiology and professor of Physical Medicine and Rehabilitation at Northwestern Medicine, discusses the latest advancements in epilepsy diagnosis and surgical treatment. He talks about indications for epilepsy surgery and pre-surgical evaluation, including the 5-SENSE score, which can predict the outcome of more invasive explorations with stereotactic depth electrodes (SEEG), according to a study published in JAMA Neurology that he co-authored. Dr. Schuele also discusses exciting clinical trials currently underway and innovative treatment options offered at the Northwestern Medicine Comprehensive Epilepsy Center, including neuromodulation and laser ablation.

This episode compares and contrasts the use of grid versus stereoEEG electrodes for intracranial epilepsy focus localization. Dr. Joseph Neimat will provide his input into the diverse and potentially controversial viewpoints surrounding this topic. Guest Faculty: Joseph Neimat, MD, MS Co-hosts: Rushna Ali, MD and Seth F. Oliveria, MD, PhD

Às vésperas da abertura da 26ª Conferência das Nações Unidas sobre as Mudanças Climáticas (COP26), em Glasgow (Escócia), o governo do Brasil espera convencer o mundo de que passou a levar a sério o desmatamento da Amazônia e que integrou um planejamento de crescimento verde na sua economia. Mas, na prática, o maior compromisso do país com a comunidade internacional chega atualizado “para pior" no evento. Lúcia Müzell, da RFI No fim de 2020, o então ministro do Meio Ambiente, Ricardo Salles, aumentou a base de cálculo que permite ao país emitir ainda mais gases de efeito estufa do que o estabelecido no Acordo de Paris sobre o Clima, em 2015. A manobra foi apelida de "pedalada ambiental”. O governo modificou a Contribuição Nacionalmente Determinada do Brasil (NDC, na sigla em inglês), que previa a redução de 37% das emissões até 2025 e 43% até 2030, em comparação às de 2005. Esses índices permaneceram idênticos – embora especialistas apontem que o país teria condições de diminuir bem mais. O pior, porém, é que a base de cálculo foi alterada para cima (de 2,1 para  2,8 bilhões de toneladas de CO2), o que dá ao país uma margem extra para despejar na atmosfera 400 milhões de toneladas de carbono a mais do que estava previsto há seis anos. O maior objetivo da COP26 é justamente o contrário: que os países aumentem as suas promessas de corte de emissões, já que na trajetória atual, o planeta se encaminha para uma elevação de 2,7ºC da temperatura global até o fim do século, na comparação com a era pré-industrial. “Nós temos um procedimento na Justiça pedindo para o governo brasileiro reapresentar a sua promessa porque as que foram colocadas são totalmente vexatórias. Esse é um tipo de movimento que vem crescendo pelo mundo, de pressão da sociedade pelas vias judiciais”, afirma o secretário-executivo do Observatório do Clima (OC), Márcio Astrini. Nesta terça-feira (26), a entidade protocolou uma ação civil pública na Justiça Federal do Amazonas contra a União e o Ministério do Meio Ambiente, para pedir a atualização do Plano Nacional sobre Mudança do Clima. "Lançado em 2008, o plano é a espinha dorsal das políticas públicas de redução de gases-estufa no Brasil, mas nunca foi atualizado", argumenta o OC.  Fim do desmatamento Para a COP26, o único avanço concreto até agora é que o Brasil antecipou em 10 anos a sua promessa de atingir a neutralidade de carbono, até 2050. A expectativa é de que, durante a conferência, o governo também adiante a meta de acabar com desmatamento ilegal até o fim desta década – analistas garantem que esse objetivo seria possível já em 2025, com ações efetivas de fiscalização e combate. Nesta semana, o ministro do Meio Ambiente, Joaquim Leite, e o da Economia, Paulo Guedes, apresentaram o Programa Nacional de Crescimento Verde, ao lado da cúpula do governo federal, incluindo o presidente Jair Bolsonaro. O plano, num total de US$ 400 bilhões, integra a estratégia para apresentar o Brasil como “a maior economia verde do mundo”. A iniciativa, no entanto, não deve bastar para que o país desembarque na COP com mais credibilidade. Na principal lição de casa do Brasil, a queda do desmatamento, o governo tem resultados catastróficos a apresentar: desde 2018, a devastação da Amazônia aumentou 46%, ressalta Astrini. “É um governo que induz ao desmatamento, ao crime ambiental, e isso vai danificando a imagem do país mundo afora e diminui capacidade do Brasil de ter assento e voz nesses fóruns internacionais”, avalia. "O Brasil acaba ficando mais para o final da fila, falando por menos tempo e sendo menos considerado, afinal está andando na contramão do que o mundo precisa”, constata. Importância da Amazônia para o mundo A maior parte das emissões brasileiras tem origem no desmatamento, que responde por 44% do total, segundo o SEEG, o Sistema de Estimativas de Emissões de Gases de Efeito Estufa do Observatório do Clima. Conforme a metodologia, o país se situa entre a quarta e a sexta posição entre os que mais emitiram gases de efeito estufa, que provocam o aquecimento do planeta. O que acontece no Brasil impacta, portanto, diretamente nos objetivos globais para enfrentar o problema: sozinha, a Amazônia tem a capacidade de estocar o equivalente a cinco anos das emissões do mundo inteiro, como explica Marcelo Furtado, facilitador da Coalizão Brasil Clima Florestas e Agricultura. A entidade reúne mais de 300 empresas, organizações da sociedade civil e pesquisadores sobre as mudanças climáticas. "O fato de a gente ter 60% da Amazônia no nosso território é uma bênção e é uma tremenda responsabilidade. O mundo sem a floresta amazônica em pé não vai chegar no objetivo de só 1,5ºC de aumento da temperatura até 2100. É por isso que as pessoas olham tanto para o Brasil e estão tão preocupadas com o que a gente está fazendo aqui”, frisa Furtado. "Eles sabem que sem essa floresta em pé, a gente não vai conseguir chegar lá. Então, tem uma expectativa de que nós façamos a nossa parte: é manter a floresta amazônica em pé, recuperar tudo que foi degradado, construir uma economia sustentável e pegar toda a nossa agricultura e mudá-la para uma agricultura sustentável”, destaca o especialista.

One summer weekend in northern Michigan years ago, I ate breakfast at a Bob Seger themed diner. Pretty much just a few Seger album covers framed and on the wall and an autographed photo signed by Alto Reed. The menu items did not have any Seeg related puns. Just regular breakfast item names.  They missed the boat on not naming something Kat-ham-du. What you'll hear. Gaunt – Insangel  Zurich Cloud Motors – Trails Of No Return  Giant Sand – Searchlight  Midnight Steppers – Diamonds On The Golden Road To Hell  -words from your host-  The Sueves – Mop Bucket  Daughter Bat and the Lip Strings – No Excuse For You  Spiritual Mafia – Hybrid Animal  Red Asphalt – Phone Call From God  -words from your host-  Mononegatives – Trauma  Cabaret Voltaire – The Set Up  Delilah Holliday – Feel  JSBX – Lovin’ Machine  -words from your host-  Collate – Genesis Fatigue  Nick & the Nod – New Content  Piranhas - Blinking Light  Germ House – Final Touches  -words from your host-  Reigning Sound – A Little More Time  Smirk – Violent Game  Lousy Sue – Rats  Blue Cheer – Just A Little Bit  -words from your host-   We gladly accept tips!   Get even more Smashin' Transistors action at Facebook, Tumblr, Twitter and Instagram

Giridhar  Kalamangalam, MD evaluates surgical options for medically refractory epilepsy. He helps to identify patients who may benefit from invasive EEG (SEEG) studies and helps us to understand the principles, benefits and limitations of SEEG.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.18.256669v1?rss=1 Authors: Lin, F.-H., Lee, H.-J., Ahveninen, J., Jaaskelainen, I. P., Yu, H.-Y., Lee, C.-C., Chou, C.-C., Kuo, W.-J. Abstract: Intracranial stereoelectroencephalography (sEEG) provides unsurpassed sensitivity and specificity for human neurophysiology. However, sEEG group analyses are complicated because the electrode implantations differ greatly across individuals. Here, using an auditory experiment as the test case, we developed a distributed, anatomically realistic sEEG source-modeling approach for within- and between-subject analyses. In addition to intracranial event-related potentials (iERP), we also estimated the sources of high broadband gamma activity (HBBG), a putative correlate of local neural firing. The source models accounted for a significant portion of the variance of the sEEG measurements in leave-one-out cross-validation. After logarithmic transformations, the sensitivity and signal-to-noise ratio were linearly inversely related to the minimal distance between the brain location and electrode contacts (slope{approx}-3.6). The HGGB source estimates were remarkably consistent with analyses of intracranial-contact data. In conclusion, distributed sEEG source modeling provides a powerful neuroimaging tool, which facilitates anatomically-normalized group analyses of both iERP and HBBG. Copy rights belong to original authors. Visit the link for more info

Heute mit dem Böblinger Seegärtle-Wirt Uwe Hutfilz, der während der Aufnahme die Hiobsbotschaft erhält, dass Gaststätten ab Samstag komplett geschlossen bleiben müssen.

Unsere Reise durch die Region führt uns diesmal ins Ostallgäu: Wir nehmen Sie mit nach Seeg, Rückholz, Eisenberg, Wald, Hopferau und Lengenwang. Hören Sie rein.

Als Schaffhausen den Atem anhielt: Chronik des Kettensägen-Angriffs; Mindestens 50 Feuertote in Griechenland; Seegrundstück «Seegüetli» in Wädenswil ist nicht sicher genug

Als Schaffhausen den Atem anhielt: Chronik des Kettensägen-Angriffs; Mindestens 50 Feuertote in Griechenland; Seegrundstück «Seegüetli» in Wädenswil ist nicht sicher genug

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