Podcasts about cd5

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Best podcasts about cd5

Latest podcast episodes about cd5

Ian McKenzie's Blues Podcasts
Episode 647: ACOUSTIC BLUES CLUB #609, OCTOBER 09, 2024

Ian McKenzie's Blues Podcasts

Play Episode Listen Later Oct 9, 2024 58:59


 | Artist  | Title  | Album Name  | Album Copyright  |  | Heritage Blues Orchestra, Junior Mac, Bill Sims & Chaney Sims  | Get Right Church  | And Still I Rise  | 2012 Stoney Plain  |   | Henry Townsend  | Now Or Never  | Cairo Blues  |   |   | Freddie Spruell  | Freddie Spruell/Let's Go Riding  | When The Levee Breaks, Mississippi Blues (Rare Cuts CD A)  | 2007 JSP Records  |   | CeDell Davis  | Rollin' and Tumblin'  | Playing for the Man at the Door Disc 2  | Arthur Crudup  | Train Fare Blues (Remastered)  | Crudups After Hours  |   | Chris O  | Stocking Feet Blues  | Peckman's Plateau  |   |   | Hans Theessink & Terry Evans  | Got To Keep Moving  | Visions  |   |   |   | Blind Willie Johnson  | Nobody's Fault But Mine  | The Complete Blind Willie Johnson (1 of 2)  | Andres Roots  | Trouble In Mind  | Mono  |   |   |   | Martin McNeil  | Ain't No Love In The Heart Of The City  | Sweet Soul Slide  |   |   | Robert Johnson  | Hell Hound On My Trail  | The Complete Recordings;  The Centennial Collection  | Sue Foley  | Lonesome Homesick Blues  | One Guitar Woman  |   |   | Andy Cohen  | Reverend Gary Rag  | Andy Cohen Small But Mighty  | Mean Mary  | Cranberry Gown  | Portrait of a Woman Part 1  |   | Half Deaf Clatch  | The Superlative Spiel  | Dr Bloodwort's Nefarious Medicine Show  | Mississippi Fred Mc Dowell  | Highway 61  | American Folk Blues Festival 1962-1965  CD5

Ian McKenzie's Blues Podcasts
Episode 643: ACOUSTIC BLUES CLUB #607, SEPTEMBER 25, 2024.

Ian McKenzie's Blues Podcasts

Play Episode Listen Later Sep 25, 2024 58:59


 | Artist  | Title  | Album Name  | Album Copyright  |  | Seasick Steve  | Just Because I Can  | Man From Another Time  |   | Amedie Ardoin & Dennis McGee  | Two Step De La Prairie Soileau  | The Stuff that Dreams are Made Of (disc 1)  | Pink Anderson  | In The Jailhouse Now  | Blues Legend  |   |   | Charles -Cow Cow- Davenport  | Alabama Strut  | Complete Recorded Works, Vol. 1  | Guy Davis  | Ramblin' All Over  | The Adventures Of Fishy Waters In Bed With The Blues (2012)  -   | Ma Rainey  | Little Low Mama Blues  | Classic Blues Artwork From  the 1920's  | Gary Fletcher.  | It's Just Feel.  | River Keeps Flowing'  |   |   | Seasick Steve & The Level Devils  | Cheap  | Cheap  |   |   |   | Big Bill Broonzy  | Why Do You Do That To Me  | Chicago 1937-1938 (CD8)  1937-1940 Part 2  | The Jake Leg Jug Band  | Your Feet's Too Big  | Fifth Avenue  |   |   | Arthur Montana Taylor  | Five O' Clocks (NYC 28/6/47)  | Montana Taylor  |   |   | Bukka White  | The Promise True And Grand  | The Vintage Recordings 1930 -1940  | Gladys Bentley  | Ground Hog Blues (1928)  | Broadcasting the Blues, volume 2  | Merle Travis  | Louisiana Boogie  |   |   |   | Blind Willie McTell  | That Will Never Happen No More (Remastered 2018)  | Last Session - Remastered  | Prestige/Bluesville Records  | J.B. Lenoir  | If I Get Lucky  | American Folk Blues Festival 1962-1965  CD5  |  

Chuck and Julie Show with Chuck Bonniwell and Julie Hayden
Chuck and Julie Show, June 21, 2024

Chuck and Julie Show with Chuck Bonniwell and Julie Hayden

Play Episode Listen Later Jun 22, 2024 47:24


The Chuck & Julie Show with Chuck Bonniwell and Julie Hayden With Guests, Tim Leonard and grassroots candidate in Weld County, Trent Leisy In the last few days before the primary, The UniParty RINOs double down on attacks against grassroots CD5 candidate Dave Williams. Supporter Tim Leonard sets the record straight. Plus another grassroots candidate in Weld County, Trent Leisy censored by the Establishment.

BBS Radio Station Streams
Chuck and Julie Show, June 21, 2024

BBS Radio Station Streams

Play Episode Listen Later Jun 22, 2024 47:24


The Chuck & Julie Show with Chuck Bonniwell and Julie Hayden With Guests, Tim Leonard and grassroots candidate in Weld County, Trent Leisy In the last few days before the primary, The UniParty RINOs double down on attacks against grassroots CD5 candidate Dave Williams. Supporter Tim Leonard sets the record straight. Plus another grassroots candidate in Weld County, Trent Leisy censored by the Establishment.

The Johnny Beane Podcast
Talking About The Police SYNCHRONICITY 40TH ANNIVERSARY Box Sets LIVE! 5/30/24

The Johnny Beane Podcast

Play Episode Listen Later May 31, 2024 48:52


https://youtube.com/live/YyKsnl_D6Ps?feature=share The Police are set to release a 6CD super deluxe edition of their acclaimed 1983 album, Synchronicity. This extensive reissue includes a wealth of previously unheard alternate takes, outtakes, and demos. As their fifth and final studio album, Synchronicity features hit singles such as "Every Breath You Take," "Wrapped Around Your Finger," "King of Pain," and "Synchronicity II." The album has sold 15 million copies globally, with 8.5 million in the USA alone. This reissue project, which took three years to complete, was created with the band's involvement and endorsement. It includes a 60-page hardcover book with comprehensive new sleeve notes by music journalist Jason Draper, detailing the album's creation and history. The box set contains: CD1: The original album, including "Murder By Numbers," remastered from the original tapes. CD2: 18 tracks featuring all original 7" / 12" B-sides plus 11 exclusive non-album bonus tracks, available on CD for the first time. CD3 and CD4: Previously unreleased alternate takes of all the Synchronicity songs. CD4 also includes unreleased Police tracks, such as an early version of Andy Summers' "Goodbye Tomorrow" (later renamed "Someone To Talk To"), a demo of Stewart Copeland's "I'm Blind" (later "Brothers on Wheels" for the Rumble Fish soundtrack), a first take of "Truth Hits Everybody," and rare covers of Eddie Cochran's "Three Steps To Heaven" and Chuck Berry's "Rock and Roll Music." CD5 and CD6: 19 previously unreleased live recordings from the September 10, 1983, concert at the Oakland-Alameda Coliseum, USA. The 6CD box also includes four art prints. Additional formats include a 2CD set (repeating the first two discs of the super deluxe edition), a 4LP vinyl edition (42 tracks), and a vinyl picture disc with a revised track order. #thepolice #Synchronicity #sting #stewartcopeland #andysummers #johnnybeaneTV

Matt Kim Podcast
Can a Korean American Republican make it to Congress? | w/ George Song | Matt Kim #095

Matt Kim Podcast

Play Episode Listen Later May 30, 2024 77:23


George Song is running for Congress in CD5 in Northern NJ. Bergen, Passaic, and Sussex County. His Republican primary is next week. Listen to what he has to say. George Song X: https://twitter.com/georgesong IG: https://www.instagram.com/george4nj/ Support and Learn: www.george4nj.com --- Support this podcast: https://podcasters.spotify.com/pod/show/mattkimpodcast/support

Ian McKenzie's Blues Podcasts
Episode 598: ACOUSTIC BLUES CLUB #583, APRIL 10, 2024

Ian McKenzie's Blues Podcasts

Play Episode Listen Later Apr 10, 2024 59:00


 | Artist  | Title  | Album Name  | Album Copyright  | Sue Foley  | Oh Babe It Ain't No Lie  | One Guitar Woman  |   | Joe Bonamassa  | Richmond  | Acoustic Evening at the Vienna Opera House  | Tampa Red  | It's Red Hot  | Bottleneck Guitar 1928-1937  | Big Walter Horton  | Blues Harp Shuffle  | American Folk Blues Festival 1962-1965  CD5  | Sue Foley  | Freight Train  | One Guitar Woman  |   | Mary Flower  | Raise the Devil  | Instrumental Breakdown  | Robert Johnson  | Honeymoon Blues  | The Complete Recordings;  The Centennial Collection  | Half Deaf Clatch  | Coney Island Baby  | Songs From The Clatch Cave -Vol 3  | Jo Carley &The Old Dry Skulls  | Little Limbs Of Satan  | Voodoo Bones & Vaudeville Blues MP3's  | Snooks Eaglin  | Drifting Blues  | New Orleans Street Singer  | Sue Foley  | Motherless Child Blues  | One Guitar Woman  |   | Lonnie Johnson and Eddie Lang  | Two Tone Stomp  | Jazz Legends  |   | Adam Franklin  | Tuckin' With My Baby (On A Friday  | England's Newest Hit Maker - The Best Of Adam Franklin  | Jimmy Yancey  | 1. Yancey Stomp  | Blues and Boogie  |   | Sue Foley  | Nothing in Rambling  | One Guitar Woman  |   | Big Bill Broonzy  | Beedle Um Bum  | Complete Recorded Works in Chronological Order Vol. 1

The Chuck and Julie Show
Cue Establishment Attacks

The Chuck and Julie Show

Play Episode Listen Later Mar 26, 2024 49:35


Grassroots candidate Dave Williams wins big in CD5 assembly.  Right on cue UniParty/Eatablishment launch divisive attacks.  Plus the latest on Trump lawfare.  

Political Coffee with Jeff Kropf
Political Coffee 3-20-2024: Josh Michael interview about ORP convention, Appeals Court blocks TX law that SCOTUS just said ok, CD5 embarassment for Dems? Sen Bonham calls for Kotek to veto union money kickback bill and Does govt have a right to censure fr

Political Coffee with Jeff Kropf

Play Episode Listen Later Mar 20, 2024 43:17


Josh Michael interview on what happened down at the ORP convention: https://noncompliantamerica.transistor.fm/ Appeals Court blocks new TX law that allows TX to arrest and deport illegal aliens after SCOTUS says its ok: https://www.thegatewaypundit.com/2024/03/just-appeals-court-blocks-texas-arresting-deporting-illegals/ CD5 embarrassment for Dems? https://oregoncatalyst.com/76294-senate-2-lawsuit-bentz-backs-despain-cd5-embarrassment-fear.html Sen Bonham calls for Kotek to veto union money kickback bill: https://oregoncatalyst.com/76304-sen-bonham-call-kotek-veto-political-kickback-bill.html Does the Government have a right to censure our speech? https://www.thegatewaypundit.com/2024/03/supreme-court-judge-jackson-says-quiet-part-loud/ 

The Craig Silverman Show
Episode 202 - Colorado Democratic Party Chair Shad Murib

The Craig Silverman Show

Play Episode Listen Later Mar 16, 2024 163:56


Rundown -    Shad Murib - 08:19   Troubadour Dave Gunders - 01:36:50   "If God Was Watching" by Dave Gunders - 01:53:53   Senate Majority Leader Chuck Schumer's Speech - 01:57:52   Find out why Colorado Dems elected this dynamic leader. Murib grew up in Littleton, Colorado, the son of Arab Lebanese immigrants. Murib learned valuable life lessons growing up in his south Denver suburb, especially when his sibling announced as a lesbian. Murib is a proud progressive.   As a Democratic stalwart with talent, Shad Murib has worked for and with Senator John Hickenlooper, Colorado AG Phil Weiser and Colorado Governor Jared Polis. He's married to former State Senator Kerry Donovan and they were married by their friend and political colleague, State Senator Dylan Roberts.    We find out about the Copper Bar Ranch that Shad and Kerry own and run high up in Edwards, Colorado. They raise Scottish Highland cattle and wait till you hear the taste described, especially the tenderloin. Stress-free ethical slaughter makes the taste difference. Hear it explained at the end. https://www.thecopperbarranch.com/   This name-dropping episode features further mentions of Colorado's top elected officials with a special shout-out to Rep. Jason Crow and Senator Michael Bennet for their dedication to trying to protect freedom in Ukraine. The host and guest salute the performance of President Biden too, standing up to Putin, Trump and the GOP.   Colorado Republican Chair Dave Williams gets discussed, including his taunts at his party chair counterpart. When MAGA goes low, Shad Murib responds with winning policies, strategies and powerful responses. The process in the Colorado CD4 special election necessitated by Rep. Ken Buck's resignation is thoroughly explained.   Murib intends for Democrats to be competitive in every part of Colorado including CD5. What will the impact be of Trump's endorsements of Boebert (CD4) and Dave “Let's Go Brandon” Williams in CD5? The connections of Putin to Trump to MAGA-GOQP gets reviewed with Murib worried about fascism.   Shad Murib goes on Fox News and will debate any semi-honest broker, but we discuss how far gone Twitter (X) is now with Elon Musk platforming the likes of Alex Jones. Modern media get discussed as do conflicts amongst Dems at the Colorado Capitol.   DA races are partisan in Colorado as are Sheriff races. Dems need to compete smarter and harder especially with disingenuous MAGA law enforcers refusing to enforce gun laws like Red Flag which they do not like. Local races are big, but the huge political issue is Trump v the rest of us. Dems must lead us now. ​​ https://www.coloradodems.org/   Troubadour Dave Gunders provides a lively conversation about the NYC trial delay. He also loved the SOU by POTUS. His song, If G-d was Watching is aimed at MAGA-GOP-type hypocrites who make money off of Big Lies like Big Con Don, the MAGA-GOQP nominee. https://soundcloud.com/dave-gunders/7-if-god-was-watching   The Craig Silverman Show - Every Saturday morning at 9 a.m. Colorado time

The Chuck and Julie Show
GOP Primaries Galore. The Chuck and Julie Show January 8, 2024

The Chuck and Julie Show

Play Episode Listen Later Jan 9, 2024 50:33


It's a great 2024 election season for CO GOP as grassroots warriors lead the field congressional primaries.   Dave Williams for CD5 and Ron Hanks for CD3 join the show.  Plus an unexpected boost for Trump's Colorado Supreme Court case.

The George Show Podcast
George 1-8-24 7am

The George Show Podcast

Play Episode Listen Later Jan 8, 2024 42:00


The Colorado GOP Party Chair is running for Congress, while staying in the job.  That news breaks 1/2 way through the hour.  George kicks this hour off with Editor of Westword, Patty Calhoun to talk about the Supreme Court taking up the Colorado Trump ballot case, the Broncs lose again, and more.  Next, former CO GOP Party Chair Kristi Burton Brown talks about her fight for religious educational funding in Colorado.  She is calling out the Dems for pulling back funding that was okay last year but is not now for a really bogus reason.  Next, she and George talk about Dave Williams running for CD5 while remaining as party chair.  See omnystudio.com/listener for privacy information.

T'agrada el blues?
Ted Horowitz, Popa Chubby

T'agrada el blues?

Play Episode Listen Later Jan 3, 2024 56:22


El programa "T'agrada el blues" d'aquesta setmana presenta el darrer disc del bluesman de blues rock Ted Horowitz, Popa Chubby (tamb

Ian McKenzie's Blues Podcasts
Episode 546: ACOUSTIC BLUES CLUB #554 SEPTEMBER 20, 2023

Ian McKenzie's Blues Podcasts

Play Episode Listen Later Sep 20, 2023 59:00


 | Artist  | Title  | Album Name  | Album Copyright  |  | Charles -Cow Cow- Davenport  | Everybody Likes That Thing  | Complete Recorded Works, Vol. 2  (1929-1945) | Otis Spann  | One More Mile to Go  | The Blues Never Die!  |  | J.B. Lenoir  | Slow Down Woman  | American Folk Blues Festival 1962-1965  CD5 | Paul Rishell  | Special Rider Blues [Skip James]  | Talkin' Guitar  |   |  | Big Bill Broonzy  | Double Trouble Blues  | Do That Guitar Rag  |   |  | John Hammond  |  Drop Down Mama  | Timeless  |   |   |  | Lightnin' Hopkins  | I'm Comin' Home  | Morning Blues - Charley Blues Masterworks Vol. 8 | Mike Ross  | None Of Your Business  | Tennessee Transition  |  | Seasick Steve  | Man From Another Time  | Man From Another Time  |  | Henry Townsend  | Henry's Worry Blues  | Searching For Secret Heroes  | Document Records  |  | Duster Bennett  | Got A Tongue In Your Head  | Smiling Like I'm Happy (Vinyl) - 1968  | Fiona Boyes  | Easy Baby  | Fiona Boyes Box & Dice promo  |  | Half Deaf Clatch  | Astrally Challenged  | Short Songs for the Barely Conscious | Skip James  | Omaha Blues  | Studio Sessions Rare & Unreleased | Bill Abel  | Special Rider  | Celestial Train  |   |  | Tampa Red  | You Can't Come In  | Tampa Red Vol. 1 (1928-1929)  | 

Ian McKenzie's Blues Podcasts
Episode 524: ACOUSTIC BLUES CLUB #540 JUNE 14, 2023

Ian McKenzie's Blues Podcasts

Play Episode Listen Later Jun 14, 2023 58:58


 | Artist  | Title  | Album Name  | Album Copyright | Arthur Montana Taylor  | Sweet Sue (rec Chicago 18/4/46)  | Montana Taylor  |  | Tampa Red  |  It's Red Hot  | Bottleneck Guitar 1928-1937 | Lightnin' Hopkins  | Wake Up Old Lady  | Goin' Away (1963)  |  | Half Deaf Clatch  | The Elysian Blues  | Simple Songs For These Complicated Times | Seasick Steve  | Purple Shadows  | Hubcap Music  |  | Blind Willie Johnson  | If I Had My Way I'd Tear The Building Down  | The Complete Blind Willie Johnson (1 of 2) | Sonny Terry & Brownie McGhee  | Hey Baby Hey Baby You're So Sweet - [ASH GROVE 1-21-1967 1ST SH  | Ash Grove 01-21-1967 1st Show | Bill Abel  | Don't You Hurt (Instrumental)  | One-Man Band  |  | Tony Joe White  | Baby Please Don't Go  | Bad Mouthin' (2018) | Andres Roots  | Thanks For Bringing Me Down  | Winter  |   |  | Washboard Sam  | Phantom Black Snake  | Washboard Swing  |  | Paul Cowley  | Preaching Blues  | Stroll Out West  |  | R. L. Burnside  | Goin' Down South  | First Recordings  |  | Lonnie Johnson  | C.C. Rider (Traditional)  | American Folk Blues Festival 1962-1965  CD3 | John Hammond  | Sugar Mama  | Sooner Or Later (2002 reissue) - 2002 - 320 - FC | Mississippi Fred Mc Dowell  | Highway 61  | American Folk Blues Festival 1962-1965  CD5

Ian McKenzie's Blues Podcasts
Episode 519: ACOUSTIC BLUES CLUB #538 MAY 31, 2023

Ian McKenzie's Blues Podcasts

Play Episode Listen Later May 31, 2023 58:58


 | Artist  | Title  | Album Name  | Album Copyright  |  | Skip James  | Hard Time Killin' Floor Blues  | The Complete Early Recordings of Skip James - 1930 | James Cotton  | River's Invitation  | 22 Special Blues Tracks  |  | Tina Turner-  | Let's Stay Together [acoustic]  |   |  | John Lee Hooker  | Let's Make It Baby  | American Folk Blues Festival 1962-1965  CD1 | Half Deaf Clatch  | Mind Over  Matter  | Short Songs for the Barely Conscious | Bessie Jones & with the Georgia Sea Island Singers  | Once There Was No Sun (II)  | Get In Union  | Alan Lomax Archives/Association For Cultural Equity | John James  | Remembering The Blossoms  | Cafe Vienna  |   |  | Blind Willie Johnson  | God Don't Never Change  | The Complete Blind Willie Johnson (1 of 2) | Hans Theessink and Big Daddy Wilson  | Virus Blues  | Pay Day  |   |   |  | Mean Mary  | Merry Eyes  | Portrait of a Woman Part 1  |  | Andres Roots  | Winter Blues  | Winter  |   |   |  | Bukka White  | Hambone Blues  | Furry Lewis, Bukka White & Friends Party! at Home - 1968 | Big Bill Broonzy  | The Banker's Blues  | Complete Recorded Works in Chronological Order Vol. 1 | Stompin' Dave's Blues3  | My Heart Belongs To You  | The Mayfair Studio  |   |  | Doc Watson and Gaither Carlton  | Groundhog (Blind Lemon's Version)  | Doc Watson and Gaither Carlton  | Smithsonian Folkways | Furry Lewis With Bukka White And Gus Cannon  | Why Don't You Come Home Blues  | On The Road Again  |   |  | J.B. Lenoir  | If I Get Lucky  | American Folk Blues Festival 1962-1965  CD5

Ian McKenzie's Blues Podcasts
Episode 516: ACOUSTIC BLUES CLUB #537 MAY 24, 2023

Ian McKenzie's Blues Podcasts

Play Episode Listen Later May 24, 2023 58:59


 | Artist  | Title  | Album Name  | Album Copyright  |   |  | Son House  | Clarksdale Moan  | When The Levee Breaks, Mississippi Blues (Rare Cuts CD A)  | 2007 JSP Records  |   |  | Roosevelt Sykes  | Come On Back Home  | American Folk Blues Festival 1962-1965  CD5 | Doc Watson & Rec Live Newport Folk Fest 1963/4  | Little Orphan Girl  | The Essential Doc Watson  |   |  | Sonny Terry and Brownie McGhee  | John Henry (Recorded Live At The Free Trade Hall, Manchester, E  | Chris Barber Presents The Blues Legacy Lost & Found Series  | Lightnin' Hopkins  | 4. Stool Pigeon Blues  | Folk Blues Revival  |   |   |  | Snooks Eaglin  | Mailman Passed  | That's Alright  |   |   |  | John Hammond  | My Starter Won't Start  | You Can't Judge A Book By The Cover - 1993 | Half Deaf Clatch  | Waiting For The Storm to Pass  | The Album With No Name  |   |  | Blind Willie McTell  | Experience Blues  | Complete Recorded Works, Vol. 2 (1931-1933) | Jelly Jaw Short  | Barefoot Blues  | When The Levee Breaks, Mississippi Blues (Rare Cuts CD C)  | 2007 JSP  Records  |   |  | Andres Roots Roundabout  | Miss Carmen James  | Three!  |   |   |   |  | Tony Joe White  | Heartbreak Hotel  | Bad Mouthin' (2018)  |   |  | Fiona Boyes  | Party at Red's  | Voodoo In The Shadows  |   |  | Seasick Steve & The Level Devils  | Cheap  | Cheap  |   |   |   |  | Seasick Steve  | Happy (To Have A Job)  | Man From Another Time  |   |  | David Evans  | Don't Leave Me Here  | Lonesome Midnight Dream  |   | 

Small Town Charm
C-Deez Overlays

Small Town Charm

Play Episode Listen Later Mar 6, 2023 27:47


We'll discuss how CD5 got brought back essentially in all its glory, and we dig in to what the anti-CD5 commissioners might have been thinking in pressing so hard not to just bring it back- but bring it back larger and denser than ever. Hosted on Acast. See acast.com/privacy for more information.

Small Town Charm
Zoning Public Forum Recap

Small Town Charm

Play Episode Listen Later Feb 27, 2023 28:18


Liz and Caitlin join us for a brief recap of the public forum on the Zoning Rewrite. As we inch closer to the vote, and hopefully compromise, here's how you can get involved:SHOW UP in Purple! March 2 at 6:30PM at Town Hall for the BOC meeting.SPEAK UP by coming prepared with up to 3 minutes of public comments supporting your vision for a Village Center in Nolensville.If you can't speak, or are uncomfortable doing so: email your thoughts to our 5 commissioners:jmiller@nolensvilletn.govhgallik@nolensvilletn.govjsalamida@nolensvilletn.govdadams@nolensvilletn.govkcortner@nolensvilletn.govSIGN UP on the petition to bring CD5 back: https://change.org/wearethevillage Hosted on Acast. See acast.com/privacy for more information.

Small Town Charm
Save Our Village

Small Town Charm

Play Episode Listen Later Feb 20, 2023 51:50


Liz and Caitlin join us again to discuss why it is that Brentwood has the same tax rate as Nolensville, but has amazing fire stations, one of the best libraries in the state. Meanwhile Nolensville's public works department doesn't have a bathroom, and one of our police officer's office is a closet. And what does all of this have to do with CD5? We'll discuss...Important Upcoming Meetings:February 21 @ around 6pm (Meeting Starts at 4 but Public Comments typically start around 6pm)Public HearingMarch 2 @ 6:30pmBOC Meeting - arrive early to secure a seatEmail Your BOC Members:hgallik@nolensvilletn.govjmiller@nolensvilletn.govjsalamida@nolensvilletn.govdadams@nolensvilletn.govkcortner@nolensvilletn.govSign the petition to bring back CD5 Hosted on Acast. See acast.com/privacy for more information.

Small Town Charm
Doctors Recommend Pizza and Candy

Small Town Charm

Play Episode Listen Later Feb 16, 2023 28:57


We continue our discussion about the positive aspects of CD5 and how we have a unique opportunity to positively shape our town for generations to come.Click here to sign the petition to bring back CD5 Hosted on Acast. See acast.com/privacy for more information.

Small Town Charm
Her Argument Does Make Sense... To Her

Small Town Charm

Play Episode Listen Later Feb 13, 2023 27:07


Just when we thought the BOC would compromise for the sake of the Town of Nolensville, they suddenly removed CD5 from the new zoning ordinance. What is CD5 and what benefits would we all see as a result? Two special guests join us to discuss...Click here to sign the petition to Save CD5 Hosted on Acast. See acast.com/privacy for more information.

T'agrada el blues?
Joe Bonamassa

T'agrada el blues?

Play Episode Listen Later Jan 11, 2023 59:07


El programa "T'agrada el blues?" d'aquesta setmana i primer d'aquest any 2023 que tot just comen

Chad Hartman
Minneapolis Mayor Jacob Frey on new Commissioner of Community Safety Cedric Alexander and safety downtown

Chad Hartman

Play Episode Listen Later Aug 4, 2022 16:48


Mayor Jacob Frey joins Chad just hours after the City Council approved the appointment of Cedric Alexander as the first Commissioner of Community Safety. He also discusses crime and violence downtown and his recent endorsement of Don Samuels in the CD5 race against Ilhan Omar. 

I Spy Radio Show
Whoa! Oregon Primed & Ready… For Conservative Candidates & First-Time Politicians?

I Spy Radio Show

Play Episode Listen Later Apr 30, 2022 48:00


Show Summary: This week, we welcome three guests, all candidates for office. Dr. Angela Plowhead (running for U.S. Congress in Oregon's CD 6), Marc Thielman (running for Oregon's governor), and Dr. John Di Paola (running for U.S. Congress in CD5). All three need your help to cross the finish line. Find out why they should … Read More Read More The post Whoa! Oregon Primed & Ready… For Conservative Candidates & First-Time Politicians? appeared first on The I Spy Radio Show.

Justice & Drew
Hour 2: Royce White

Justice & Drew

Play Episode Listen Later Apr 7, 2022 39:48


Justice & Drew fall down a Cracker Jacks rabbit hole after a recent news story broke about how they are introducing "Cracker Jills." Later, they are joined by Royce White, a candidate running for Congress in CD5.

Justice & Drew
Hour 3: Shukri Abdirahman vs. Ilhan Omar

Justice & Drew

Play Episode Listen Later Mar 3, 2022 45:35


Justice & Drew discuss the crisis in Ukraine before they're joined by CD5 candidate Shukri Abdirahman, and they discuss her campaign against Ilhan Omar.

Bike Talk
Bike Talk - What Can a Mayor Do (Or a Mom)?

Bike Talk

Play Episode Listen Later Jan 23, 2022 58:00


John Bauters, The Mayor of the City of Emeryville, California, campaigned on a platform that supported affordable housing, expanding active transit infrastructure, and making Emeryville more sustainable and environmentally resilient. John bikes the talk on his 41 mile commute to Bay Area Air Quality Management District meetings, where he's the Vice Chair. Melanie Curry, Editor of Streetsblog California, did this interview specially for Bike Talk. https://sf.streetsblog.org/2022/01/19/what-can-a-mayor-do-to-make-a-city-more-livable/ Then: Sarah Risser survived the crash that killed her son, Henry, in 2019. After the DA brushed off factors which implicated the other driver, Sarah began her journey of advocating for victims' rights. Taylor Nichols, Los Angeles Bicycle Advisory Committee Representative for CD5, interviews Sarah. https://twitter.com/Henryz_mom Edited by Kevin Burton

Blood & Cancer
How I treat CLL and MCL: From ‘watch and wait’ to BCL2 and BTK inhibitors, CAR T-cell therapy, and transplant

Blood & Cancer

Play Episode Listen Later Mar 11, 2021 22:51


Treatments for chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) have advanced in recent years, with more new developments on the horizon. James Gerson, MD, of the University of Pennsylvania, Philadelphia, reviewed some of these advances and future directions while describing how he would treat three patients. Host David H. Henry, MD, posed the following cases for consideration. Case 1 In a 75-year-old male with no comorbid illness, routine blood work revealed a WBC count of 15,000/mcL. The manual differential showed mature lymphocytes and smudge cells. The patient has no constitutional symptoms, but there is suspicion of CLL. What to do? An incidental finding of elevated WBC is the most common presentation for CLL, Dr. Gerson noted. Flow cytometry is how most diagnoses are made. If the patient’s blood sample is CD5+ and CD20+, in the vast majority of cases, the patient has CLL. The main alternative diagnosis is MCL, so Dr. Gerson recommends checking for cyclin-D1 overexpression and translocation (11;14), which would be present in MCL. Dr. Gerson also recommends fluorescence in situ hybridization (FISH), cytogenetics, and next-generation sequencing to assist with prognostication. When the exam is normal and the patient is asymptomatic, no imaging is required. For this patient, treatment should be deferred until disease progression. Case 2 A 75-year-old, fit male has a WBC of 25,000/mcL, noted after the patient reported not feeling well, having a distended abdomen, night sweats, and weight loss. Blood work shows a hemoglobin level of 10.5 g/dL and a platelet count of 130 x 103/mcL. What to do? Because this patient is symptomatic, treatment is indicated, Dr. Gerson said. However, because of the pandemic, Dr. Gerson would likely delay therapy, perhaps until after COVID-19 vaccination. To assess risk, Dr. Gerson would perform immunohistochemistry, FISH, and next-generation sequencing in this patient. Patients with 17p deletion have high-risk disease, those with TP53 missense or nonsense mutations have even higher-risk disease, and patients with both a deletion and a mutation are “at excessively high risk,” Dr. Gerson said. He favors giving a BTK inhibitor to patients with TP53 mutation/17p deletion because of results from the CLL14 trial (N Engl J Med 2019; 380:2225-36. https://bit.ly/38pVHbf). However, because of the “small signal” in the trial, Dr. Gerson said plenty of his colleagues use a BTK inhibitor interchangeably with a BCL2 inhibitor and anti-CD20 therapy (e.g., venetoclax and obinutuzumab). Dr. Gerson said ibrutinib and acalabrutinib have similar efficacy, according to unpublished results of the ELEVATE-RR trial (https://bit.ly/38onIjy). Both drugs inhibit platelets, and there appears to be a higher risk of atrial fibrillation with ibrutinib. Case 3 A 75-year-old, fit male has an elevated WBC, noted after complaints of bone pain, weight loss, night sweats, and enlarged lymph nodes. There is suspicion of MCL. What to do? MCL is a complicated disease and “incredibly” heterogeneous in clinical and pathological behavior, Dr. Gerson noted. The classic finding in MCL is cyclin-D1 overexpression caused by (11;14) translocation, but there are atypical translocations as well. The approach to first-line treatment of MCL varies and may include cytarabine-based induction, bendamustine plus rituximab, or rituximab alone. Brexucabtagene autoleucel, a chimeric antigen receptor T-cell therapy, is changing the landscape of treatment for relapsed/refractory MCL, Dr. Gerson said, as this treatment may offer a cure. Investigational therapies for MCL include the BTK inhibitor pirtobrutinib (LOXO-305) and hematopoietic stem cell transplant. Pirtobrutinib is under investigation in patients with MCL, CLL, and other indolent lymphomas that have progressed on or are intolerant to first-line therapy (Lancet. 2021 Mar 6;397[10277]:892-901. https://bit.ly/3rvRv1h). Show notes written by Ronak Mistry, DO, a resident at Pennsylvania Hospital, Philadelphia. Disclosures Dr. Gerson disclosed relationships with Loxo Oncology, Genentech, Pharmacyclics, and TG Therapeutics. Dr. Henry has no relevant disclosures. *  *  * For more MDedge Podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com Interact with us on Twitter: @MDedgehemonc David Henry on Twitter: @davidhenrymd

Justice & Drew
Hour 3: Lacy Johnson & Andrew Langer

Justice & Drew

Play Episode Listen Later Oct 28, 2020 42:07


Ilhan Omar challenger Lacy Johnson joins Justice & Drew to discuss his campaign in CD5 as well as Omar's calls to pack the court following ACB's confirmation. Later, they chat with D.C. Correspondant Andrew Langer about the Bobulinski claims.

The Bella Dangelo Show
criminal defense attorney needed took the mask ripping a tad too far

The Bella Dangelo Show

Play Episode Listen Later Oct 14, 2020 64:00


Back from 3 Trump rally's , I will not comply nor deny there may be a few body bags .... this masking new nation of genius police must end. Join us to hear from Lacy Johnson from CD5 , Omar has a real challenger finallly ! Matt Bliss the former and future state rep from Bemidji . Listen in to the unique voice in Conservative talk radio , here to entertain you , get you laughing learning , listening ! 

The Bella Dangelo Show
criminal defense attorney needed took the mask ripping a tad too far

The Bella Dangelo Show

Play Episode Listen Later Oct 14, 2020 63:12


Back from 3 Trump rally's , I will not comply nor deny there may be a few body bags .... this masking new nation of genius police must end. Join us to hear from Lacy Johnson from CD5 , Omar has a real challenger finallly ! Matt Bliss the former and future state rep from Bemidji . Listen in to the unique voice in Conservative talk radio , here to entertain you , get you laughing learning , listening ! 

Justice & Drew
Hour 2: Trump's Taxes & Ilhan's Ballot Harvesting

Justice & Drew

Play Episode Listen Later Sep 28, 2020 44:09


D.C. Correspondant Andrew Langer joins Justice & Drew to discuss Trump's tax returns being reported on by the New York Times. Later, they discuss recent Project Veritas video that was released that seems to show evidence of ballot harvesting in Minnesota's CD5.

Let's Pod This
Do candidates really moderate after a primary?

Let's Pod This

Play Episode Listen Later Aug 29, 2020 70:27


We discuss some of the most notable results from this week's primary run-off election, including: (1) Bice squeaks out a win over Neese for CD5 nomination (and what happens to Bice's campaign now as she turns to face Congresswoman Horn in November), (2) Tommie Johnson bests incumbent PD Taylor for OK County Sheriff, thereby guaranteeing OK County will have its first black sheriff, and (3) three #okleg incumbents lost their seats, all for very different reasons. Only 10 weeks until the general election! Support this podcast

money.power.land.solidarity.
30. Antone's Oligarchs

money.power.land.solidarity.

Play Episode Listen Later Aug 10, 2020 45:49


We dive into the tricky waters of electoral politics with a special report on the eve of the CD 5 primary.  The squad looks into the donations from members of the Billionaire Pohlad family to Antone Melton-Meaux in his effort to primary Ilhan Omar, contrast the visions of the two candidates and the discuss the battle between the forces of reaction and progress playing out in the CD5 race. Isaac also reports on the Pohlad's hefty donations to Mayor Jacob Frey and tracks donations from other big money real estate interests at the city level. Season 2 coming soon!  Please rate, review and subscribe us on your podcast app and become a patron:)  patreon.com/moneypowerlandsolidarity

Best of Interviews - AM950 The Progressive Voice of Minnesota
Antone Melton Meaux (FYI Politics 7/10/20)

Best of Interviews - AM950 The Progressive Voice of Minnesota

Play Episode Listen Later Jul 13, 2020 19:40


Brett Johnson recently spoke to Antone Melton Meaux, who is challenging current rep. Ilhan Omar for the DFL nomination in CD5.

The 365 Days of Astronomy, the daily podcast of the International Year of Astronomy 2009
Travelers in the Night Eps. 531 & 532: Alex's Catch & Teddy's Debut

The 365 Days of Astronomy, the daily podcast of the International Year of Astronomy 2009

Play Episode Listen Later Apr 12, 2020 5:29


Dr. Al Grauer hosts. Dr. Albert D. Grauer ( @Nmcanopus ) is an observational asteroid hunting astronomer. Dr. Grauer retired from the University of Arkansas at Little Rock in 2006. travelersinthenight.org Today's 2 topics: - Alex Gibbs discovered 8 new celestial visitors with the 60 inch telescope, including 2019 CR4 & 2019 CD5. - Teddy Pruyne & Richard Kowalski discovered six new Earth Approaching Objects, including 2019 CL5.   We've added a new way to donate to 365 Days of Astronomy to support editing, hosting, and production costs. Just visit: https://www.patreon.com/365DaysOfAstronomy and donate as much as you can! Share the podcast with your friends and send the Patreon link to them too! Every bit helps! Thank you! ------------------------------------ Do go visit http://astrogear.spreadshirt.com/ for cool Astronomy Cast and CosmoQuest t-shirts, coffee mugs and other awesomeness! http://cosmoquest.org/Donate This show is made possible through your donations. Thank you! (Haven't donated? It's not too late! Just click!) The 365 Days of Astronomy Podcast is produced by Astrosphere New Media. http://www.astrosphere.org/ Visit us on the web at 365DaysOfAstronomy.org or email us at info@365DaysOfAstronomy.org.

Justice & Drew
Hour 3: Dalia Al-Aquidi & Katie Pavlich

Justice & Drew

Play Episode Listen Later Jan 30, 2020 42:31


Justice & Drew are joined by CD5 candidate Dalia Al-Aquidi to discuss her campaign and her choice to run against Ilhan Omar. Later, they're joined by Katie Pavlich.

Justice & Drew
Hour 2: Gun Laws & Chris Kelly

Justice & Drew

Play Episode Listen Later Aug 8, 2019 43:01


Justice & Drew discuss Amy Klobuchar and the rally against gun violence that happened at the capitol yesterday before chatting with Chris Kelly, who is challenging Ilhan Omar in the CD5 race.

Impact SoFlo
The REAL REAL

Impact SoFlo

Play Episode Listen Later Jul 31, 2019 12:34


"The REAL REAL" from the "Impact Summer" series by Minister Lonay Bostic. Released 2019. Genre: Gospel. CD5

Community Solutions Podcast
Episode 80- We Call Shenanigans

Community Solutions Podcast

Play Episode Listen Later Sep 12, 2018 75:53


www.commsolutionsmn.com- Cities are pretty much known for raising your taxes every year. They incrementally spend a little more and a little more. They may throw in some bonding for big projects, franchise fees, permits, and a general assessment, and it's all meant to keep your property taxes low by hiding these taxes somewhere else. Other cities just go for it. Some cities are so bad, that they continually get used as an example by surrounding cities to say "at least we're not that bad". New Hope is one such city. They have set their initial property tax levy at for 18.99% 2019! Why do they do it? Because no one will stand up and challenge them. No one runs for office to challenge the incumbents. Listen to how bad it gets when no one cares enough to challenge the status quo. You may say it's not a big deal because the economy is good. What happens when the economy tanks and your city is double digit million of dollars in debt. Don't let this happen to your city. We also discuss the charges against Keith Ellison, and what that means to his run at Minnesota Attorney General. While we agree that everyone deserves to face their accuser and be considered innocent until proven guilty, we were surprised at the lengths the Star Tribune went to cover for Rep. Ellison instead of do any investigative journalism to uncover the facts to get down to the truth. In related news, Rep. Ilhan Omar has a laundry list of traffic/moving violations over the past few years, plus an ongoing investigation of violations of House rules and state law. We believe that due to the sheer number, that it exposes a more troubling trend. She obviously has no regard for our laws, yet we will most certainly send her to Washington to make them. We called her campaign for more information, and they refused to answer our questions. Do you think that she will protect the constitution that protects us? How do you think this ends for us? The socialist "tear it down" crowd is getting stronger, and we need to stand now, more than ever. Where are our George Washingtons and Thomas Jeffersons? We need you, and we need you now. Please contact us. Have you checked out our Spotify playlist? At the beginning of each episode Jason quotes some song lyrics that have to do with the subject matter of the podcast. Andrew never knows what they are, but now he can… and so can you! We’ve launched the Spotify playlist: “Community Solutions Music From the Podcast“! You can listen to Roundabout from Yes after listing to Episode 30 on Roundabouts… or kick back and enjoy a rocking playlist just for the thrill of it. We add a new song every week. Subscribe and enjoy! Don’t forget that you can also subscribe to our podcast on iTunes, Google Play, and Spotify, or go out to the PodBabble Podcast Network!  

Latina Theory
29: WOC in Politics: Commissioners Irene Fernando and Angela Conley, Rep. Erin Maye Quade, and Congresswoman Ilhan Omar

Latina Theory

Play Episode Listen Later Aug 14, 2018 61:07


**Latina Theory** hosted a special episode at Irene Fernando's **Hype Crew Concert** celebrating WOCI in politics in Minnesota.   Tune into our conversations with these four incredible leaders: * **[Irene Fernando](https://www.voteirene.com/),** Hennepin County Commissioner, District 2 * **[Rep. Erin Maye Quade](https://murphyformn.com/)**, joined Erin Murphy and ran as LT Governor in 2018 race * **[Angela Conley,](https://www.voteconley.com/) H**ennepin County Commissioner, District 2 * **[Rep. Ilhan Omar](https://www.ilhanomar.com/)**, Congresswoman, CD5 Get a behind the scenes conversation with each powerful WOC elected officials on the campaign trail; hear the stories of how they got involved in politics and why.  Each of these muxeres is running to make a difference and to show that women of color can and will continue to be a force to be reckoned with.  **Episode Playlist** Ain’t No Mountain High Enough- Marvin Gaye and Tammi Terrell Electric Lady- Janell Monáe Family Feud - Jay-Z Feat. Beyoncé Waving’ Flag- K’naan Django Jane - Janelle Monáe

The Humanist Hour
The Humanist Hour #124: James Woods, Too Sensible to Be Electable

The Humanist Hour

Play Episode Listen Later Nov 12, 2014


In this episode, Bo Bennett speaks with James Woods, an openly-atheist congressional candidate for Arizona's 5th district. Though he lost in the November 4 general election, his trailblazing campaign helped pave the way for other openly secular candidates in the future. Read about James Woods (in his own words): I've lived in Arizona my whole life. I was born in the Arizona East Valley and raised by good-hearted working class parents. My dad is one of my best friends and supporters. We lost my mom to cancer in 2002, but I think she would be proud of how close and strong our family has remained. I graduated from Dobson High in ‘97 and went to Mesa Community College, working toward a career in the tech industry. I wanted the kind of job where I could support myself and a family, but also contribute to the quality of life in Arizona by developing technology-based solutions to the problems our state faces. A month before my 27th birthday, I was hospitalized for a rare illness that nearly killed me. I didn't have health coverage. I survived organ failure and amputations. While my medical team fought to keep me alive, my vision started fading. On a Monday I told the doctor that things were starting to look dim, and by Friday I never saw again. I ended up on dialysis and even spent time in hospice. I would not be alive today without all the people who invested in me. You invested in me through your contributions to government programs like Medicaid, Social Security Disability and Nutrition Assistance. My dad invested in me and became my caregiver. And someone I never met gave me a new chance at a healthy life through organ donation. After all of that generosity and support, it's time for me to start giving back. Last February I received a new kidney, and from my hospital bed in Phoenix I signed the paperwork to run for the US Congress in Arizona's CD5. After my long struggle to get the health care I needed and the losses I experienced when I couldn't get it, I knew I had an opportunity to start advocating for change. There is a damaging disparity between the decision-makers in Washington and the people who have to live with the decisions they make. We deserve representatives who know what it's like to face hard times and what's needed to overcome them. I can provide that representation. I have already overcome some tough odds, and I believe it's time to overcome the conservative ideology that hurts the most vulnerable among us.

Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 01/19
Verlaufsuntersuchung zellulärer Immunparameter bei schizophrenen Patienten

Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 01/19

Play Episode Listen Later Jun 26, 2003


Schizophrenia has often been observed to be associated with alterations of the cellular immune system. In this study we monitored numerous immune parameters in the course of antipsychotic treatment. 40 patients diagnosed with an acute exacerbation of schizophrenia were tested before and during treatment with antipsychotics. The percentual distribution of lymphocyte subgroups (CD3, CD4, CD8, CD19, CD5, CD16/56, CD25, HLA-DR, gd, CD11a, CD11b and CD49d) was measured by FACS analysis. 20 healthy volunteers served as controls. In the acute state of psychosis a significant elevation of the B-lymphocyte fraction was observed, while the percentage of T-lymphocytes was decreased. These values levelled to those of the control group in the course of treatment. Natural killer cells, integrine expressing cells and CD5+ B-cells showed alterations in numbers after several months of treatment. The latter may be a side effect of antipsychotic treatment. The findings in the acute state of schizophrenia could be seen as a nonspecific stress reaction or an effect of the altered metabolism of neurotransmitters. On the other hand the observed changes in the immune system could be due to infectious diseases or autoimmune processes provoking the symptoms of schizophrenia.

natural patienten schizophrenia facs cd4 cd3 cd8 cd19 zellul cd5 ddc:600 hla dr cd25 cd16 cd11b schizophrenen
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 01/19
Untersuchung des zellulären Immunsystems schizophrener Patienten mittels Durchflusszytometrie

Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 01/19

Play Episode Listen Later Oct 31, 2002


Bei schizophrenen Patienten sind immunologische Veränderungen nachweisbar, die auf eine Aktivierung des Immunsystems hinweisen und die seit langem diskutierte Hypothese stützen, dass das Immunsystem in der Pathogenese der Schizophrenie involviert ist. Es gibt Anhaltspunkte, die die Annahme eines inflammatorischen - sei es infektiös oder autoimmunologisch getriggerten - Prozesses im Gehirn schizophrener Patienten stützen, der zu einer erhöhten Permeabilität der Blut-Hirnschranke führt und für die psychopathologische Symptomatik verantwortlich gemacht wird. In dieser Arbeit wurden mittels Dreifarben-Durchflusszytometrie (FACS-Analyse) Lymphozyten-Subpopulationen von 31 schizophrenen Patienten bestimmt und sowohl mit Befunden gesunder Kontrollpersonen, als auch desselben Patienten vor und nach Neuroleptikabehandlung verglichen. Gemessen wurde die Expression einer Auswahl von Oberflächenantigenen, die den Aktivierungszustand des Immunsystems anzeigen bzw. mit autoimmunologischen Prozessen in Verbindung gebracht werden. Dadurch war es möglich allgemeine immunologische Veränderungen des peripheren Immunsystems schizophrener Patienten zu erfassen und diese auch im Verlauf der Therapie mit Neuroleptika, sowie in Korrelation mit psychopathologischem Befund und Prognose zu betrachten. Die in dieser Arbeit gezeigten Ergebnisse stützen die Hypothese, dass bei schizophrenen Patienten eine Aktivierung des Immunsystems vorliegt. So fand sich bei Schizophrenen nach Behandlung im Vergleich zu Kontrollen eine Erhöhung der CD4-positiven T-Zellen – ein Befund, der auch bei Autoimmunerkrankungen gesehen wird und dort für die chronische Stimulation von B-Lymphozyten verantwortlich gemacht wird. Zusätzlich wurden Patientengruppen anhand des psychopathologischen Verlaufes und des Therapieerfolgs gebildet. Ein Zusammenhang bestand zwischen dem Ansprechen auf Therapie und CD8-positiven T-Lymphozyten: Die Patientengruppe mit niedrigerem Anteil von CD8+- Zellen, also weniger Suppressorzellen, zeigte ein schlechteres Ansprechen. Ein weiteres Aktivierungszeichen des zellulären Immunsystems ist die Expression des CD45RO-Moleküls anstelle von CD45RA auf CD4-positiven Lymphozyten. Auch hier konnte bei schizophrenen Patienten ein erhöhter Anteil von CD4+/CD45RO+- (Gedächtnis-) Zellen, insbesondere nach Behandlung, beobachtet werden, wobei wiederum Patienten mit schlechterem Ansprechen auf Therapie stärkere Veränderungen zeigen. Unterstrichen wird dieser Befund durch die parallele Zunahme der Expression des Adhäsionsmoleküls CD58 und CD60 bei Schizophrenen unter Behandlung, sowie zusätzlich bei schlechter Therapieantwort. Eine Expression dieser Moleküle weist auf die Fähigkeit zur transepithelialen Migration der Zellen, auf eine weitere Immunaktivierung und Stimulation von B-Zellen hin. Ebenfalls ähnlich wie bei Autoimmunerkrankungen wurde in der hier untersuchten Patientengruppe eine erhöhte Expression von HLA-DR gefunden. Dies, wie auch eine geringe Zahl von CD4+/45RA+-Lymphozyten, die als Suppressor-Inducer-Zellen bekannt sind, kann als fehlende Suppression von Autoimmunreaktionen interpretiert werden. Darüberhinaus scheint ein schlechtes Outcome der Patienten mit insgesamt erhöhter immunologischer Aktivität assoziiert zu sein. Die Ergebnisse im Bezug auf CD5+/19+- Zellen und NK-Zellen runden das Bild einer Modulation immunologischer Mechanismen im Verlauf einer schizophrenen Störung und durch neuroleptische Therapie ab. In der Literatur beschriebene Störungen der Blut-Hirnschranke und Reaktionen des hirneigenen Immunsystems weisen auf eine Interaktion von peripherem und zentralem Immunsystem im Rahmen der Erkrankung hin. In der akuten Phase der Schizophrenie scheint dabei die Aktivierung des Th2-Systems im Vordergrund zu stehen. Im Verlauf der neuroleptischen Behandlung findet dann ein Wechsel zum Th1-System statt. Veränderungen im Zytokinsystem sind von besonderem Interesse, da diesen Botenstoffen eine Vermittlerrolle zwischen Immunsystem und Nervensystem zukommt und so ein Einfluss auf neurometabolische Vorgänge erklärbar ist. Die in dieser Arbeit beobachteten Veränderungen unter Neuroleptikatherapie sprechen für einen immunmodulatorischen Wirkmechanismus dieser Substanzen. Für die Substanz Clozapin sind beispielsweise derartige Effekte bekannt. Bei der Schizophrenie handelt es sich um eine heterogene Krankheitsentität, für die es zahlreiche Erklärungsmodelle gibt. Die hier erhobenen Befunde stehen in Einklang mit Ergebnissen anderer Studien und können diese zum Teil bestätigen und ergänzen. Allerdings finden sich in der Literatur diskrepante und umstrittene Befunde bezüglich der zellulären und humoralen Veränderungen des Immunsystems, die die Komplexität des Krankheitsbildes deutlich machen und vielleicht als Ausdruck ätiologischer Unterschiede angesehen werden können.

Tiermedizin - Open Access LMU
Identification of a Candidate CD5 Homologue in the Amphibian Xenopus laevis

Tiermedizin - Open Access LMU

Play Episode Listen Later Jan 1, 1995


We identified a novel T cell Ag in the South African clawed toad (Xenopus laevis) by a mAb designated 2B1. This Ag is present in relatively high levels on most thymocytes, approximately 65% of splenocytes, 55% of PBL, and 65% of intestinal lymphocytes, but is rarely seen on IgM+ B cells in any of these tissues. Lymphocytes bearing the 2B1 Ag proliferate in response to stimulation with Con A or PHA, whereas the 2B1- lymphocytes are reactive to LPS. Biochemical analysis indicates that this Ag is a differentially phosphorylated glycoprotein of 71 to 82 kDa. The protein core of 64 kDa bears both N- and O-linked carbohydrate side chains. The amino-terminal protein sequence of the 2B1 Ag shares significant homology with both the macrophage scavenger receptor type 1 motif and the mammalian CD5/CD6 family. The biochemical characteristics and cellular distribution of the 2B1 Ag suggest that it represents the CD5 homologue in X. laevis. While T cells constitutively express this highly conserved molecule, Xenopus B cells acquire the CD5 homologue only when they are stimulated in the presence of T cells