Podcasts about Horowitz

Get personalized root-cause care with Empower Functional Health.Learn more at empowerfunctionalhealth.com_____Why do some people remain chronically ill even after treating Lyme disease, mold exposure, or Long COVID? Dr. Richard Horowitz joins me to break down his 16-point MSIDS model and the overlapping factors he looks for in complex chronic illness, including Lyme and Bartonella, Babesia, mold and mycotoxins, mast cell activation (MCAS), gut dysfunction, POTS, mitochondrial dysfunction, immune dysregulation, and nervous system health.We also get into some of the most provocative areas of his recent work: Alzheimer's disease and p-tau217, his dapsone protocols for persistent Lyme and Bartonella, why some patients struggle with treatment, how he decides what to address first, and what may determine why one person recovers after an infection while another develops chronic illness. Dr. Horowitz also explains why looking beyond a single diagnosis may change how we think about Long COVID, chronic Lyme disease, mold illness, brain health, and recovery.We discuss the following:The 16-point MSIDS model and episode previewLyme, mold, MCAS, Long COVID: what do you treat first?How long does meaningful healing actually take?Long COVID, mast cells, Lyme, Bartonella, and moldWhy Bartonella can be so difficult to identify and treatWhat to do when your doctor isn't looking at the full pictureAlzheimer's disease, Lyme, and the p-tau217 case studyThe surprising dementia statistic Dr. Horowitz discussesDapsone, inflammation, and Alzheimer's researchWhat if you can't tolerate the dapsone protocol?Herbal protocols, biofilms, and persistent LymeDr. Horowitz's approach to mold and mycotoxinsWhy chronic illness requires a different frameworkWhat happens when the infection is gone but the body still feels unsafe?Stress, mast cells, histamine, and the mind-body connectionWhy do some people develop chronic Lyme or Long COVID while others don't?The philosophy that shaped Dr. Horowitz's approach to medicineFinal message for people struggling with chronic illness_____EPISODE RESOURCESWork with us one-on-oneEnding Chronic Illness: A Revolutionary New Program to Reverse Inflammation and Heal Persistent Disease Medical Detective SubstackDr. Richard Horowitz WebsiteDr. Richard Horowitz FacebookDr. Richard Horowitz InstagramCan Carnivore Heal Chronic Lyme? – Understanding Chronic Lyme Symptoms - Interview with Dr. Richard Horowitz_____WEEKLY NEWSLETTER

In this episode, Dr. David Jockers sits down with Dr. Richard Horowitz, integrative medicine pioneer, creator of the MSIDS model, and author of the new book Ending Chronic Illness, to talk about solving the toughest chronic illnesses, from Lyme disease and Alzheimer's to autoimmune conditions and chronic fatigue.   You will learn about Dr. Horowitz's groundbreaking case study in the Journal of Alzheimer's Disease Reports, where a nine-week oral dapsone combination protocol fully reversed the Alzheimer's biomarker p-tau 217, plus why Lyme is called "the great imitator" and how the three Bs (Borrelia, Babesia, and Bartonella), mold toxins, and POTS are driving so much of today's chronic illness.   Dr. Jockers and Dr. Horowitz also cover the six rivers of inflammation and the 16-point MSIDS model, the daily supplements Dr. Horowitz takes to block key inflammatory pathways, how to start with highly sensitive patients, gut healing and H. pylori strategies, and why trauma, limbic retraining, and vagal retraining can be the missing piece in recovery.   In This Episode:  00:00 Overmedicated Lyme Patient 00:18 Meet Dr Richard Horowitz 00:54 Alzheimers Biomarker Breakthrough 11:12 Lyme Mimics Chronic Disease 14:01 MSIDS Six Rivers Explained 16:33 Where To Start Testing 23:51 New Trends Bartonella Mold POTS 34:45 Bioengineered Lyme Debate 36:24 Biofilm Infection Basics 37:43 Dapsone Breakthrough Story 39:18 Root Causes MSIDS Approach 40:14 Lifestyle Foundations 41:49 Anti Inflammation Supplements 46:55 Inflammatory Pathways Explained 51:32 Sensitive Patients Detox First 54:29 Gut Healing And H Pylori 56:52 Trauma Limbic Vagal Reset 01:00:20 Closing Hope And Next Steps   Nearly every benefit of turmeric comes down to its ability to encourage a healthy inflammatory response, and research shows whole food turmeric can be even more powerful than isolated curcumin, with nearly 300 beneficial compounds. That's why I love the Turmeric Complex from Paleovalley, which pairs organic turmeric with coconut oil and black pepper to boost absorption by up to 2,000%, plus organic ginger, rosemary, and cloves for added brain, digestive, immune, and blood sugar support. Go to paleovalley.com/jockers for 15% off your order.   Red light therapy is one of the simplest ways to restore your skin's glow, calm the complexion, and soften visible signs of aging, and you can now get professional-grade results at home in just 10 to 20 minutes a day. The red light face mask from Bon Charge uses red and near-infrared wavelengths to energize the mitochondria in your skin cells, with a cordless, flexible design that's comfortable to wear and HSA/FSA eligible for tax-free savings of up to 40%. Go to boncharge.com and use promo code DRJOCKERS for 15% off, plus free shipping and a 12-month warranty.   Two people can have completely different microbiomes, and completely different needs, even when their symptoms look the same, which is why it pays to test rather than guess. An at-home gut test from Tiny Health uses metagenomic sequencing to analyze your full gut ecosystem, revealing signs of inflammation, leaky gut, and imbalances, then gives you a personalized action plan for diet, lifestyle, and supplements. Go to tinyhealth.com/drjockers for $50 off your first at-home test kit.   Inflammaging, the chronic low-grade inflammation that accelerates aging, often shows up first in your skin as puffiness, fine lines, and wrinkles. A simple way to fight back is the Frankincense Castor Oil roll-on from Holistic Goddess, which combines organic castor oil and organic frankincense to deeply moisturize and soften the look of fine lines, with a cooling rose quartz roller that feels great around puffy eyes. It's USDA organic, cold pressed, hexane free, and third-party tested. Go to holisticgoddess.com and use code DRJOCKERS for free shipping. "Sixty percent of Americans have one chronic illness, twenty-five percent have two or more."   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean  TuneIn Radio   Resources:  Visit paleovalley.com/jockers to get 15% off Paleovalley Turmeric Complex and other products Visit boncharge.com and use promo code DRJOCKERS to get 15% off the Bon Charge Red Light Face Mask Visit tinyhealth.com/drjockers to get $50 off your first Tiny Health at-home gut test kit Visit holisticgoddess.com and use code DRJOCKERS to get free shipping on Holistic Goddess Frankincense Castor Oil   Connect with Dr. Richard Horowitz: Book: https://a.co/d/03XW4lQs Website: https://cangetbetter.com/ Substack: https://medicaldetective.substack.com/ Facebook: https://www.facebook.com/drrichardhorowitz YouTube: https://www.youtube.com/@richardhorowitz1963   Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/

Tick-borne illnesses are, unfortunately, something many of us who love spending time outdoors have a personal relationship with. If you haven't had one yourself, you likely can think of someone you know who has had one.And I questioned putting out an episode on tick-borne illnesses in late Autumn, but then I remembered an article that I wrote a couple of years back about how tick season is not only expanding to new areas across the country, but in many places the season is much longer than it used to be, too. Dr. Horowitz is a board-certified internal medicine doctor and medical director of the Hudson Valley Healing Arts Center, an integrative medical center that combines both mainstream and integrative approaches in the treatment of Lyme disease and other tick-borne disorders. He has treated over 13,000 Lyme and tick-borne disease patients over the last 42 years, with patients coming from around the world to his clinic, and has advised HHS, the NY State Department of Health, as well as government agencies across the globe. His research and dedication to studying, understanding, and listening to patient concerns have helped lead many of his patients into long-term remission from Lyme disease.And in episode 232 of the Outdoor Minimalist podcast, we benefit from him sharing that knowledge with us so we can get outside more safely and help protect our families, including our pets, from ticks and the many diseases they carry. Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/outdoor.minimalist.book/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.theoutdoorminimalist.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/@theoutdoorminimalist⁠⁠⁠⁠⁠⁠⁠⁠Buy Me a Coffee: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://buymeacoffee.com/outdoorminimalist⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----------------Dr. HorowitzEnding Chronic Illness: https://cangetbetter.com/Facebook: https://www.facebook.com/drrichardhorowitzSubstack: https://medicaldetective.substack.com/----------------Episode Sourceshttps://lymeconnection.org/support_and_resources/meet_the_lyme_disease_experts.html/title/dr-richard-horowitz-latest-treatments-in-lyme-disease https://www.prnewswire.com/news-releases/first-published-case-of-alzheimers-biomarker-reversal-in-a-chronic-lyme-disease-patient-using-dapsone-combination-therapy-302754488.html https://www.neurologylive.com/view/dapsone-combination-therapy-linked-alzheimer-biomarker-changes-single-lyme-disease-case-studyhttps://journals.sagepub.com/doi/full/10.1177/25424823261445434https://lifesciencedaily.news/first-alzheimers-biomarker-reversal-linked-to-lyme-disease-treatment/

This week on the ADSN Rundown, Daniel Druger and James Borow unpack Meta's decision to open Muse to developers and why connectors from Shopify, Stripe, Expedia, Instacart and others could turn it into a new consumer platform. They explore a potential open-web coalition between Meta, Shopify and Stripe, debate whether Meta will eventually acquire Shopify, and explain why the combination of social distribution, commerce data and advertising could reshape how people discover and buy products.Daniel and James also cover Alex Heath's move into investing, Peter Sellis's 90-minute product masterclass, Ramp's Broadway musical, the widening US-China divide around AI and robotics, and the $42 million Horowitz and Andreessen Academy. They close with tech trades at Pinterest and Crexi, Toby Lütke's approach to high-stakes decisions, and Nikita Bier's argument that probabilistic AI products will favor builders who are not constrained by decades of deterministic software thinking.Thank you to our sponsors:AdQuick – Making OOH advertising as easy to plan, buy, and measure as digital. adquick.comThrad.ai — Building the advertising infrastructure for AI. thrad.aibeehiiv — The all-in-one platform for newsletters, websites, and every tool you need to grow and earn. beehiiv.comThe Farm — Fraction commercial legal with an in-house approach to outside counsel. thefarmllp.comSTAY CONNECTEDJames on Twitter & LinkedIn – /jamesborowDaniel on LinkedIn, Instagram, TikTok – /danieldrugerSubscribe & leave a ⭐⭐⭐⭐⭐ review on Spotify & Apple Podcasts.

Apple Music Hall has 16 cameras and 600 seats… it's built for live concert… recordings.A16z's new alt-college in San Francisco is for future tech founders… It's Dropout University.Meta new AI app is #1 in all the app stores… But Amazon just canceled them.Plus, should you bring an Iced Coffee into a job interview?$AAPL $META $SBUXGrab your Tickets to the IPO Tour: Our In-Person OfferingSan Francisco 9/23: https://www.ticketmaster.com/event/1C0064AFB5F688BDBoston 10/14: https://tickets.citywinery.com/event/tboy-the-ipo-tour-in-person-offering-8cdhupSeattle 11/4 (21+): https://www.axs.com/events/1446394/the-best-one-yet-ticketsNEWSLETTER:https://tboypod.com/newsletter OUR 2ND SHOW:Want more business storytelling from us? Check our weekly deepdive show, The Best Idea Yet: The untold origin story of the products you're obsessed with. Listen for free to The Best Idea Yet: https://wondery.com/links/the-best-idea-yet/NEW LISTENERSFill out our 2 minute survey: https://qualtricsxm88y5r986q.qualtrics.com/jfe/form/SV_dp1FDYiJgt6lHy6GET ON THE POD: Submit a shoutout or fact: https://tboypod.com/shoutouts SOCIALS:Instagram: https://www.instagram.com/tboypod TikTok: https://www.tiktok.com/@tboypodYouTube: https://www.youtube.com/@tboypod Linkedin (Nick): https://www.linkedin.com/in/nicolas-martell/Linkedin (Jack): https://www.linkedin.com/in/jack-crivici-kramer/Anything else: https://tboypod.com/ About Us: The daily pop-biz news show making today's top stories your business. Formerly known as Robinhood Snacks, The Best One Yet is hosted by Jack Crivici-Kramer & Nick Martell. Hosted on Acast. See acast.com/privacy for more information.

Erik Torenberg sits down with Replit founder and CEO Amjad Masad and Horowitz and Andreessen Academy co-founder and CEO Gagan Biyani to ask what education should look like for a generation growing up with AI.Amjad argues that one of the most valuable things young people bring to society is their willingness to question deeply held assumptions. They discuss how education could create more room for that instinct through project-based learning, intellectual side quests, and giving students the freedom to follow an idea deeply rather than optimizing around grades and credentials.They also explore whether young founders are being pushed to professionalize too early, why Amjad thinks starting a company can sometimes be a form of “premature optimization,” and how curiosity led him from learning chess to experimenting with AI that can conduct machine-learning research.Finally, they discuss trust, judgment, and what it means to develop as a person, not just a builder, including why being contrarian and ambitious still needs to be balanced with the ability to work with other people.Resources:Follow Amjad Masad on X: https://x.com/amasadFollow Gagan Biyani on X: https://x.com/gaganbiyani Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show on SpotifyListen to the a16z Show on Apple PodcastsFollow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Ben Horowitz and Erik Torenberg sit down with Gagan Biyani to introduce the Horowitz and Andreessen Academy and discuss a bigger question: what should education look like when AI is rapidly changing the skills people need to build, work, and create?Ben and Gagan explain why they believe learning should be more focused on doing rather than studying about doing, with students building real projects, developing people skills, and working alongside companies and builders in San Francisco. The goal isn't to replace college for everyone, but to create a different path for young people who already know they want to build.They also discuss why AI could make this an unusually powerful time to be young, how project-based learning changes when everyone has access to powerful tools, why failure can be valuable when it produces real learning, and what it takes to develop the judgment and people skills that can't simply be learned from a textbook.Resources:Follow Gagan Biyani on X: https://x.com/gaganbiyaniFollow Ben Horowitz on X: https://x.com/bhorowitz Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show on SpotifyListen to the a16z Show on Apple PodcastsFollow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode, Dean Mark Trodden sits down with Michael Horowitz, Richard Perry Professor of Political Science and Director of Penn's Perry World House. They discuss Horowitz's experience working at the Pentagon, the new partnerships developing between the government and frontier AI labs like Anthropic, and the impact of autonomous weapons—both on the battlefield and U.S. defense strategy.In this season of Horizons: Beyond the Machine: AI in the World, we explore the intellectual, ethical, and societal implications of artificial intelligence through a range of disciplinary perspectives.The Omnia Podcast is a production of Penn Arts & Sciences. Be sure to subscribe to the Omnia Podcast on Apple Podcasts or wherever you get your podcasts to listen to new episodes.Learn more about Horizons, a vision that will help the School of Arts & Sciences navigate a changing world: web.sas.upenn.edu/horizons

Could Lyme disease and other chronic inflammatory triggers play a role in Alzheimer's disease—and could addressing those underlying factors change measurable Alzheimer's biomarkers? In this episode of the Tick Boot Camp Podcast, Dr. Richard Horowitz returns to discuss a provocative new case report he published exploring the relationship between Lyme disease, neuroinflammation, Alzheimer's disease biomarkers, and dapsone combination therapy. The conversation centers on a patient with a long history of Lyme disease who had an elevated phosphorylated tau 217 (p-tau217) level, an increasingly important blood biomarker associated with Alzheimer's disease. After completing a nine-week dapsone combination protocol, the patient's p-tau217 declined by approximately 63% and returned to the normal range. Her amyloid-beta 42/40 ratio also moved in a favorable direction, and she reported improved cognitive clarity. This case provides a new research question: Could infections, toxins, metabolic dysfunction, sleep disorders, microbiome disturbances, and other inflammatory drivers contribute to Alzheimer's pathology in subsets of patients—and could identifying and addressing those drivers change the course of the disease? Read the Published Study Read Dr. Horowitz's published study on SAGE Journals The case report provides the scientific foundation for much of the discussion in this episode, including the changes in p-tau217 and amyloid biomarkers following treatment. In This Episode, You'll Learn Lyme Disease and Alzheimer's Disease Dr. Horowitz reviews research that has investigated possible relationships between Borrelia burgdorferi, neuroinflammation, amyloid, phosphorylated tau, and Alzheimer's pathology. Much of the earlier work examining spirochetes and Alzheimer's disease involved brain tissue and postmortem studies. Dr. Horowitz explains why he believes studying Alzheimer's biomarkers in living Lyme disease patients may provide another way to investigate these questions. The discussion also explores an important distinction: finding an association between infection and Alzheimer's pathology does not mean every case of Alzheimer's disease is caused by Lyme disease. The Patient Who Sparked the New Case Report Dr. Horowitz describes a longtime patient with Lyme disease whose p-tau217 was substantially elevated despite her perception that her cognition was relatively good. After the patient underwent his nine-week dapsone combination protocol, repeat testing showed a substantial reduction in p-tau217, bringing the biomarker into the normal range. Dr. Horowitz also discusses changes in the patient's amyloid-beta 42/40 ratio, rheumatoid factor, and subjective cognitive function. The case led him to ask whether treatment directed at persistent infection and inflammation could influence biomarkers normally associated with Alzheimer's disease. What Is p-Tau217? A major portion of the interview focuses on the emerging use of blood-based biomarkers for evaluating Alzheimer's pathology. Dr. Horowitz discusses four primary biomarkers: p-tau217 – phosphorylated tau 217 p-tau181 – phosphorylated tau 181 Amyloid-beta 42/40 ratio Neurofilament light chain (NfL) He also discusses GFAP (glial fibrillary acidic protein) and the potential relevance of APOE genetics. Dr. Horowitz describes p-tau217 as one of the most sensitive and specific currently available blood biomarkers associated with Alzheimer's disease pathology. Amyloid May Be More Than Just “Plaque” Why does amyloid accumulate in the brain in the first place? The episode explores the concept of amyloid-beta as an antimicrobial peptide and the hypothesis that amyloid production may, in some circumstances, be part of the brain's response to biological threats. Dr. Horowitz discusses research examining potential infectious and environmental contributors to amyloid production, including: Borrelia and other bacteria Viral infections Fungal organisms Other microbes Environmental toxins The conversation then explores how a response that may initially be protective could potentially become harmful when amyloid accumulates and interferes with normal neuronal function. Amyloid, Tau and Neurodegeneration Dr. Horowitz breaks down two major features associated with Alzheimer's disease. Amyloid-beta plaques accumulate outside neurons and are associated with disrupted communication between brain cells. Tau proteins normally help stabilize structures inside neurons. Abnormally phosphorylated tau can become associated with neuronal dysfunction and neurodegeneration. The discussion also explores why some patients may have abnormal tau biomarkers without corresponding abnormalities in amyloid markers—and why much more research is needed to understand these patterns in people with chronic Lyme disease. Dapsone Combination Therapy and Cognitive Symptoms Dapsone has been a major focus of Dr. Horowitz's research into persistent Lyme disease. In this episode, he explains that his protocols involve combination therapy rather than dapsone alone and discusses his previous published work examining dapsone combination therapy in patients with persistent Lyme disease symptoms. According to Dr. Horowitz, improvements in memory, concentration, cognition, and word-finding difficulties have repeatedly been among the most notable improvements reported in his patient cohorts. He believes this observation deserves greater attention now that blood-based Alzheimer's biomarkers make it possible to investigate biological changes alongside cognitive symptoms. Dapsone, the Brain and the NLRP3 Inflammasome The discussion goes beyond dapsone's antimicrobial activity. Dr. Horowitz explains his interest in the NLRP3 inflammasome, an inflammatory pathway implicated in neuroinflammation and studied in relation to Alzheimer's disease. He proposes that dapsone could potentially have more than one relevant effect—targeting certain microorganisms as part of combination therapy while also influencing inflammatory pathways. This remains an area requiring further clinical investigation. Alzheimer's Disease May Have Multiple Drivers One of the most important themes of the interview is that Alzheimer's disease is unlikely to have a single universal cause. Dr. Horowitz applies his 16-point MSIDS (Multiple Systemic Infectious Disease Syndrome) model to cognitive decline and Alzheimer's disease. Potential contributors discussed include: Lyme disease and other infections Mold and mycotoxin exposure Heavy metals and environmental toxins Chronic inflammation Insulin resistance and blood sugar dysregulation Sleep disorders and sleep apnea Gut microbiome dysfunction Nutritional deficiencies Mitochondrial dysfunction Cardiovascular and metabolic factors Other sources of systemic inflammation Rather than focusing exclusively on amyloid or tau, Dr. Horowitz argues for investigating what may be driving those abnormalities in an individual patient. Lyme Disease Is Not the Only Possible Infectious Trigger The episode also examines the broader question of infection and neurodegeneration. Dr. Horowitz discusses scientific literature investigating organisms and infections beyond Borrelia, including Chlamydia pneumoniae, Helicobacter pylori, Coxiella burnetii, herpesviruses, and other microbial exposures. His central argument is not that every Alzheimer's patient has an infection. Instead, he believes clinicians and researchers should investigate whether infectious, toxic, metabolic, environmental, and inflammatory factors may coexist and contribute differently from patient to patient. The Challenge of Lyme Disease Testing The conversation also addresses limitations surrounding Lyme disease diagnostics. A negative standard Lyme disease test does not necessarily answer every clinical question surrounding prior exposure or persistent symptoms. The hosts and Dr. Horowitz discuss why testing methodology, timing, immune response, strain diversity, clinical history, and other factors may need to be considered when evaluating a complex patient. Dr. Horowitz also explains how he combines laboratory findings with clinical history and his MSIDS framework when evaluating patients. Why More Data Is Critical A single case can generate a hypothesis. It cannot establish a treatment standard. Dr. Horowitz repeatedly emphasizes the need for: Additional documented cases Standardized biomarker testing Long-term patient follow-up Larger patient cohorts Collaboration among Lyme-literate physicians and neurologists Shared research databases Multicenter studies Randomized controlled clinical trials The episode explores the possibility of physicians systematically collecting Alzheimer's biomarkers before and after treatment of specific MSIDS factors to determine which interventions, if any, consistently change those biomarkers. That type of data could help researchers move beyond individual clinical observations toward testable conclusions. Could Patient Data Accelerate Lyme and Alzheimer's Research? Matt and Dr. Horowitz discuss the potential for a secure research repository where physicians could contribute standardized patient data. For example, researchers could track a patient's infections, mold exposure, metabolic factors and other MSIDS variables alongside p-tau217, p-tau181, amyloid-beta 42/40 and NfL measurements. Repeating those measurements after individual interventions could help researchers identify patterns that would otherwise take years to discover through isolated clinical practices. Dr. Horowitz Is Developing an MSIDS App Dr. Horowitz also shares a major project currently in development. He says he is working with researchers from the University of California, Irvine on an application designed to translate his MSIDS framework into a digital tool. The goal is for users to enter information based on the MSIDS questionnaire and other health data, allowing the software to help guide them through the framework. Dr. Horowitz also discusses how a sufficiently large and secure database could eventually create opportunities for collecting real-world patient data and generating new research hypotheses. Lifestyle, Metabolic Health and Brain Health Not every potential driver discussed in this episode is infectious. Dr. Horowitz highlights several established areas of brain-health research, including: Mediterranean/MIND-style dietary patterns Regular physical activity Healthy blood sugar and insulin regulation Cardiovascular health Adequate sleep Addressing sleep apnea Omega-3 fatty acids Nutritional status Gut and microbiome health This reinforces one of the episode's central messages: cognitive decline may result from multiple interacting biological pressures rather than one isolated mechanism. Ending Chronic Illness The discussion also previews Dr. Horowitz's upcoming book, Ending Chronic Illness, scheduled for publication on October 13, 2026. The book expands on his 16-point MSIDS model and explores how overlapping infectious, inflammatory, environmental, metabolic, immune, neurological, and lifestyle factors may contribute to chronic disease. A separate Tick Boot Camp interview dedicated to the new book will be released this fall. Learn More About Dr. Richard Horowitz Dr. Richard Horowitz is one of the best-known physicians in the Lyme disease community and has spent decades treating patients with Lyme disease, tick-borne infections, and complex chronic illness. Tick Boot Camp has interviewed Dr. Horowitz multiple times about Lyme disease, Babesia, Bartonella, dapsone combination therapy, MSIDS, chronic inflammation, and emerging research. Visit Dr. Richard Horowitz's Tick Boot Camp page for all of our interviews, articles, and resources Additional Resources Explore all Tick Boot Camp interviews and information Key Topics Richard Horowitz, MD; Lyme disease; Alzheimer's disease; Alzheimer's biomarkers; Lyme disease and Alzheimer's; Lyme disease and dementia; cognitive decline; neuroinflammation; p-tau217; p-tau181; phosphorylated tau; amyloid beta; amyloid-beta 42/40 ratio; neurofilament light chain; NfL; GFAP; APOE4; Borrelia burgdorferi; chronic Lyme disease; persistent Lyme disease; dapsone; dapsone combination therapy; MSIDS; Multiple Systemic Infectious Disease Syndrome; biofilms; persister bacteria; brain inflammation; memory problems; brain fog; cognitive dysfunction; mold toxicity; mycotoxins; microbiome; infections and Alzheimer's disease; tick-borne disease; Lyme disease research; dementia research; Alzheimer's research.

In dieser Folge des Trending-Topics-Podcasts spricht Jakob Steinschaden mit Chris Schnabl, Investing Partner bei Andreessen Horowitz, über folgende Themen:

In this episode, we're continuing with Part 8 of the Back to the Basics series by exploring the vital role that comprehensive lab work plays in healing anxiety and depression. I break down why we take a physiology-first—but not physiology-only—approach, the truth behind the outdated “chemical imbalance” theory, and how functional labs can uncover real root causes that are often missed in standard care.3 Takeaways:Physiology First, Not Only: There's an interplay between physiology and psychology but if your body is depleted or stressed, it changes how your brain functions. You can't mindset your way out of a nervous system stuck in survival mode.The Chemical Imbalance Theory is outdated and debunked. This oversimplified narrative can prevent people from exploring the root causes of their symptoms and keeps many stuck in medication-only treatment plans that don't fully support their healing.Comprehensive Lab Work can take out some of the guesswork. It helps uncover hidden imbalances—like nutrient deficiencies or hormone issues—that may be driving anxiety or depression. It gives you clear, personalized data to support your healing.CLICK HERE for the full show notes, resources, and 3 tangible takeaways!—Ps. This is a re-run of this series.  It originally aired in February 2025, and is still the series I hear back about the most. Since there's been a wave of new listeners joining lately, I wanted to bring it back around.And for those of you who were here the first time, I invite you to listen again through the lens of where you are right now, it's likely shifted over the last year and a half, and just see what lands differently.Looking for more personalized support? 1:1 Coaching (RESTORE):  Learn more or book a free discovery call (HSA/FSA eligible & includes comprehensive bloodwork)Regulated Living Membership:  A mental health membership and nervous system healing space (sliding scale pricing available). Join here.Order my book: Healing Through the Vagus Nerve*Want me to talk about something specific on the podcast? Let me know HERE.—Disclaimer: This podcast is for informational and educational purposes only and is not a substitute for professional medical or mental health advice, diagnosis, or treatment.**Referenced Sources: Moncrieff, J., Cooper, R. E., Stockmann, T., Amendola, S., Hengartner, M. P., & Horowitz, M. A. (2022). The serotonin theory of depression: A systematic umbrella review of the evidence. Molecular Psychiatry, 28(8), 1–14. https://doi.org/10.1038/s41380-022-01661-0Website: https://www.regulatedliving.com/podcastEmail: amanda@regulatedliving.comInstagram: @amandaontheriseTikTok: https://www.tiktok.com/@amandaontherise

What does it mean when the most respected adviser in Silicon Valley tells you that you are the best chief executive he works with, while your company is heading straight into a wall?Bill Campbell said exactly that to Ben Horowitz. Campbell was advising Steve Jobs, Jeff Bezos and Eric Schmidt at the time, so Horowitz assumed the compliment was absurd. Campbell explained himself: there are plenty of good peacetime chief executives and plenty of good wartime ones, and almost nobody who can do both.Horowitz's own accounting of his career: peacetime chief executive for three days, wartime chief executive for eight years.This is the second half of a review of The Hard Thing About Hard Things. Part one covered how to survive the worst weeks. This half is about the job itself, and the way it changes underneath you while you are busy doing it.[AFFILIATE LINK TO THE BOOK]Four lessons, and two places where I part company with the book.Wartime CEO, peacetime CEO. Two situations that reward opposite behaviour, and the sixteen contrasts Horowitz draws between them. My first disagreement: his wartime leader is loud, and the ones I have watched save companies are calm, well dressed and listening. Volume is not decisiveness, and a generation of founders read that list and concluded otherwise. My second: Horowitz treats wartime as an episode. In deep tech and life science it is the standing condition, for decades. Moderna, BioNTech and Katalin Karikó are the evidence, and the numbers are in the episode.Ones and Twos. The chief executive's job splits into knowing what to do and getting the company to do it, and founders reliably come apart on the second one. Where I push back: at scale, the first skill is not knowing the answers. It is judging who has them, and holding one story that points a hundred expert answers in the same direction. Horowitz's own book says so in two passages he files under a different heading.Why the impressive senior hire produces nothing. Three new initiatives a quarter in a large company. Eight to ten a day in a small one. Rhythm mismatch, skill mismatch, the three interview questions that expose both, and what Berkshire Hathaway did when it faced the biggest succession in modern corporate history.Look for a market of one. Thirty investors say no and one says yes, and the round is closed. Why most of those thirty were never a judgment about your company, how to tell a fit rejection from a real one, and the discipline that keeps this from becoming permission to stop listening.This is a practical review for founders, chief executives, board members, investors and senior executives who build or finance hard companies, particularly in deep tech and life sciences.Part one is the previous episode, and it stands on its own if you want to start there.Chapters(00:00) Introduction: Two Chief Executives, Two Different Jobs (01:30) Lesson 4: Wartime CEO, Peacetime CEO, and Why Running the Wrong One Kills Companies (16:38) Lesson 5: Ones and Twos, and the Half of the Job Founders Get Wrong(28:26) Lesson 6: Why the Impressive Hire From the Big Company Produces Nothing (40:26) Lesson 7: Look for a Market of One, and What a Rejection Really Means (50:16) Key Takeaways and Wrap UpFollow Beginner's Mind for long-form conversations on leadership, capital, technology, and the people shaping what comes next. Ranked in the global top 10% of all podcasts, named #1 Deep Tech Podcast in 2025, and #8 Deep Tech Podcast in 2026Send us Fan Mail Join Christian Soschner for expert coaching. 50% Off - With 35+ years in deep tech, startups/scaleups, and public companies, Christian offers power video sessions. Elevate strategy, execution, and leadership. Book Now.Support the showJoin the Podcast Newsletter: Link

What do you do on the morning when there are no good moves left?In March 2001, Ben Horowitz took Loudcloud public in the middle of the dot-com collapse. The bankers cut the price from ten dollars a share to six in the week of the offering. The day before the deal, Yahoo announced its chief executive was stepping down. Neither of the two banks that took the company public offered the traditional closing dinner. On the plane home, Horowitz turned to his director of finance and said they had done it. The reply was that the company was still in very serious trouble.He was right. What followed was a share price of thirty-five cents, three rounds of layoffs, four hundred people gone, and business magazines running cover stories on the collapse.Six years later the same company sold to Hewlett-Packard for 1.6 billion dollars.The distance between those two moments is The Hard Thing About Hard Things, and it is the rare book about building companies written from inside repeated near-death rather than reconstructed afterwards from the winner's chair.[AFFILIATE LINK TO THE BOOK]Horowitz opens by attacking the genre he is writing in. Most management books offer a recipe. He argues that the situations which decide a company have no recipe, and that hunting for one is itself the failure. He then organises the book around that claim, putting the endgame material first, and explains the choice by quoting the first principle of the Bushido: keep death in mind at all times.Part one of this review covers the three lessons that belong together.The Struggle. Horowitz names the psychological state every founder recognises and almost nobody describes out loud, and then refuses to sell a way out of it. What he offers instead is a set of survival habits and one instruction: find the move.CEOs should tell it like it is. Shielding a team from bad news feels like leadership and works like sabotage. Trust is communication bandwidth. A brain cannot solve a problem it does not know about. And a healthy culture is one where bad news travels faster than good news.Lay people off yourself. The hardest act in the book, executed as a written procedure rather than improvised on the day. Why the manager has to do it rather than HR, why a layoff and a performance firing are two different acts that companies constantly blur, and why the message is always for the people who stay.Along the way: what Jensen Huang at Nvidia and Roland Busch at Siemens have in common, why Dale Carnegie's most famous principle has aged into something he never intended, and where Reed Hastings and Ben Horowitz disagree about what you owe the person you are letting go.This is a practical review for founders, CEOs, board members, investors and senior executives who build or finance hard companies, particularly in deep tech and life sciences, where the conditions Horowitz calls wartime are the default rather than the exception.Part two covers the remaining four lessons: wartime and peacetime leadership, the two halves of the chief executive's job and the half where founders reliably come apart, why the impressive executive you hire out of a large company so often produces nothing, and the rule about raising money that changes what a rejection means.Chapters(00:00) Introduction: The Least Celebratory IPO in History (02:26) The Big Idea: Keep Death in Mind at All Times (04:16) Who Is Ben Horowitz, and Why Trust Him (08:55) Lesson 1: The Struggle, and Why No Formula Exists (20:37) Lesson 2: CEOs Should Tell It Like It Is, and Why Trust Is Bandwidth (32:26) Lesson 3: Lay People Off Yourself, Because the Message Is for the People Who Stay (45:21) What Comes in Part TwoSend us Fan Mail Join Christian Soschner for expert coaching. 50% Off - With 35+ years in deep tech, startups/scaleups, and public companies, Christian offers power video sessions. Elevate strategy, execution, and leadership. Book Now.Support the showJoin the Podcast Newsletter: Link

Story of the Week (DR):L3Harris ousts CEO after investigation into conduct MML3Harris Technologies, the company that overhauled a Qatari plane now used as Air Force One, has replaced Christopher Kubasik as chairman and chief executive after an investigation determined he violated the defense contractor's code of conduct.Kubasik's alleged conduct didn't involve and has no impact on the Melbourne, Fla., company's financial reporting, controls, customer relationships or operational performance, L3Harris said Monday.The company didn't give details on when it received a report of the potential violation. With the aid of independent counsel, the board determined that Kubasik's removal would be in the company's best interest, L3Harris said. He will be allowed to retain and exercise some previously vested stock options but won't receive severance payments, benefits or accelerated stock-based awards.L3Harris Technologies Appoints Sam Mehta, Proven Aerospace and Defense Executive, as President and Chief Executive Officer“The Board determined that the Executive engaged in conduct that was not consistent with the values of the Company as outlined in its Code of Conduct.”Kubasik will still hold onto some of his options that can net him stock worth about $23 million, as well as more than 200,000 shares of stock in L3Harris that he already owns, valued at nearly $57 million. L3Harris has paid Kubasik compensation valued at $66.3 million during the past three years, including $25.6 million in fiscal 2025.The separation disclosure says the L3Harris board decided to reach a deal with Kubasik to get him to leave rather than trying to fire him for cause. Kubasik did not admit to any violation of the company code of conduct, and the deal expressively forbids any of the parties or their representatives from making public statements “inconsistent” with Monday's disclosure.AND THIS:Women at L3Harris Shared Concerns About CEO's Behavior Years Before OusterIt was a warning that was shared among women who worked for Chris Kubasik: Avoid being alone with the executive and be careful on the corporate jet.Multiple women at defense contractor L3Harris Technologies LHX had raised concerns about Kubasik's behavior, including a formal complaint from one woman to human resources that was made around 2023, according to people familiar with the matter. The employee accused the CEO of sexual harassment, the people said.Kubasik stayed on in his role. The woman left L3Harris. Not all L3Harris board members were briefed on the 2023 complaint and it is unclearOusted L3Harris CEO was previously forced out of Lockheed Martin jobChristopher Kubasik's ouster as the L3Harris CEO was not the first time he was forced out of a company amid an allegation of misconduct.In 2012, Kubasik was set to become the CEO of Lockheed Martin when he was forced to resign after an ethics investigation confirmed that he had a close personal relationship with a subordinate employee.Why Do Boards Keep Giving Misbehaving CEOs Second Chances?L3Harris Technologies' LHX chief executive is out because of misconduct allegations, and it isn't the first time: More than a decade ago, Christopher Kubasik resigned from Lockheed Martin because he was accused of having a relationship with a subordinate.The Crucial Moment That Companies Miss After They Oust a CEOIt matters how a company responds to a scandal once it's caught in one, most blow the moment by choosing secrecy over transparency. It's an opportunity to reset the culture that led to the breach in the first place, but instead “your PR team and your legal team tell you ‘Don't dig into these things—it's not good for the company,' so you silence all the debates.”.Meta faces a $1.4 trillion threat that could mean ‘turning in the keys and walking away'—but the stakes of the case reach across techThe trial involves a coalition of 29 state attorneys general in a unified case against Meta that was brought in 2023, and will be argued by lawyers representing California, Colorado, New Jersey and Kentucky. The stakes are enormous as leading government officials across the country push for Meta to be held accountable for allegedly violating federal and state laws, including the Children's Online Privacy Protection Act, or COPPA, and various consumer protection statutes.States accuse Meta of targeting children for Facebook, Instagram addiction: 'The young ones are the best ones'Meta whistleblower told jury the company took a 'don't ask, don't tell' approach to kids' safety‘Harvest their data and hide the truth from the public': Four states seek billions from Meta over child safety practicesSEC says it will stop responding to no-action requests ‘entirely'The Securities and Exchange Commission plans to stop responding to no-action requests “entirely … effective immediately,” the agency said in a statement Friday.The decision comes after the SEC sat out the bulk of the no-action process during the 2025-26 proxy season. Investor advocates have since sued the agency, alleging the change violates the Administrative Procedure Act.AI data center outrage is showing up everywhere from ads to electionsAI data center outrage is showing up everywhere from ads to electionsGOP Begs AI Firms to Fix Data Centers' “Toxic Brand” to Help Midterm Chances As A.I. Data Centers Spread, Pressure Mounts to Share ProfitsThe Data Center Industry's PR Blitz Is BackfiringData center backlash echoes fossil-fuel politicsMajor data center bills advance in California despite industry pushbackThe ‘Country Hicks' Who Refused $26 Million from an AI Data Center Bad news for Jason Kelce: Postal Service rules say you shouldn't mail pee to data centersPoliticians Who Once Championed Data Centers Are Now Bashing ThemPennsylvania Gov. Josh Shapiro cracks down on data centers, says speculators are 'scaring our communities'Data centers are using more electricity than anyone predicted. What happens next?Trump oblivious to voter fury about data centers, saying ‘the jobs are enormous and the money paid, the taxes paid, are just enormous'Politicians Turn Against Data Centers as Anger Over AI SpreadsAmazon is buying rare books and destroying them to train its AI modelsThe team's logo features a dinosaur holding a book.Data center hysteria is the new woke | OpinionBring back the corporate death penaltyMore formally known as judicial dissolution, the corporate death penalty basically happens when the government is so pissed off by the corruption or damage a corporation causes that it yanks away their charter.Andreessen Horowitz Focus of DOJ Probe Over Board DirectorsVenture capital firm Andreessen Horowitz is the focus of a Justice Department antitrust probe over whether its investment partners are improperly serving on the boards of competing artificial intelligence companies, according to people familiar with the matter.The companies at issue include Databricks Inc., one of the most valuable privately held technology companies in the world, and Fivetran Inc., both backed by the VC firm, according to the people, who asked not to be named discussing a confidential matter. Andreessen Horowitz co-founder Ben Horowitz serves on the board of Databricks, and partner Martin Casado is a board member of Fivetran. Both companies help businesses collect, organize and analyze massive troves of data.Goodliest of the Week (MM/DR):MacKenzie Scott gave California public education $461 million—and let the recipients decide how to spend every dollarMM: Andreessen Horowitz Focus of DOJ Probe Over Board Directors DRAssholiest of the Week (MM):Bill Brown and Robert Millard DRNever accountable for anything directorsL3Harris ousts CEO after investigation into conductHistory lesson:Kubasik hired in 2015 after Lockheed disaster firing, hired as COO and PresidentPresiding CEO: Michael Strianese, Chair from 2008, CEO from 2006Board: Claude Canizares (71, MIT physics professor, 2003)Thomas Corcoran (72, Carlyle, consulting, 1997)Ann Dunwoody (64, only woman, US Army Gen, 2013)Lewis Kramer (69, EY accountant, 2009)Robert Millard (66, MIT Chair, Lehman until 2008 collapse, LID, 1997)Lloyd Newton (74, only PoC - token black guy - US Air Force General, 2012)Vincent Pagano, Jr (66, lawyer, Simpson Thacher, chair of nom, 2013)Hugh Shelton (75, US Army Gen, 2011), Arthure Simon (85, accountant, 2001)8 white men, 1 woman, 1 black dude2018, Kubasik named CEO of L3 TechnologiesMichael Strianese retires and Kubasik takes overSame exact board minus Strianese2019, L3 and Harris merge to be L3HarrisKubasik added to L3Harris board, named COO and President of the company under Bill Brown, CEO and ChairSurviving the board merger:Thomas CorcoranRobert Millard - LID, nom memberLloyd Newton - chair of nomLewis KramerAdjacent - Roger Fradin of Carlyle on board, Corcoran also of CarlyleJune 2021, Kubasik becomes CEO and Bill Brown moves to exec chair (obviously)Board:Sallie BaileyBill BrownPeter ChiarelliThomas CorcoranThomas Dattilo (nom) - ex tire CEORober GradinHarry HarrisLewis Hay III (nom) - lawyer, ex CEo of NextEraLewis KramerRita LanRobert Millard (nom) - MIT Chair, LehmanLloyd Newton (nom chair) - generalSo given that the CEOs choose their successors, the nom committees approve them, the rest of the board rubber stamps it… we can thank:Michael Strianese - hires Kubasik, names him CEO at L3, despite Lockheed problemsNom approval: Ann Dunwoody (64, only woman, US Army Gen, 2013), Vincent Pagano, Jr (66, lawyer, Simpson Thacher, chair of nom, 2013), Hugh Shelton (75, US Army Gen, 2011) - a nom committee composed of the ONLY woman, two generals and a lawyer - all of whom are the LOWEST TENURED ON THE BOARD at the timeThen Bill Brown - names Kubasik CEO of combined L3Harris, one year of babysitting as exec chairNom approval: Thomas Dattilo (nom) - ex tire CEO, Robert Millard (nom) - MIT Chair, Lehman, Lloyd Newton (nom chair) - generalFamiliar names: Millard and Newton - see Kubasik all the way throughAnd the CEOs and directors can keep failing… Bill Brown on the Becton Dickinson boardRobert Millard on the Green Dot Corp (nom!), iHeartMedia, Evercore (nom!) boardsBrought on to iHeart board just 3 years after an exec there went on a racial slur rant, the company was sued for gender and wage discrimination, and a radio host of the companies were accused of severe harassment - not sure what will change?Dario Amodei“Public benefit corporation” Anthropic: Anthropic Prepares Supervoting Power for Founders as it Readies for Mega-IPOBoard: Dario Amodei, Daniela Amodei (President, Dario's sister), Yasmin Razavi (VC, crypto and prediction market investor), Reed Hastings (Netflix), Chris Liddell (ex Trump WH Deputy Secretary), and Vas Narasimhan (Novartis) - zero “public benefit” (or even public safety) peoplePublic Benefit Corporation: “A benefit corporation's directors and officers operate the business with the same authority and behavior as in a traditional corporation, but are required to consider the impact of their decisions not only on shareholders but also on employees, customers, the community, and the local and global environment”What is the impact of supervoting shares? AI on society? AI on the environment? Who on this board is even remotely qualified to answer those questions?Paul AtkinsExhausting and perpetual gaslightingSEC says it will stop responding to no-action requests ‘entirely'In order to focus Division resources on the review of Securities Act and Exchange Act filings, including those reviews that are statutorily required, for the protection of investors and facilitation of capital formation, and in light of the extensive body of guidance from the Commission and the staff available to both companies and proponents on Rule 14a-8, the Division has determined to discontinue responding to Rule 14a-8 no-action requests entirely, including those submitted under Rule 14a-8(i)(1),[2] effective immediately, unless and until the Division announces otherwise. It also will no longer respond to notices filed under Rule 14a-8(j) with a letter indicating that it will not object if a company omits a proposal from its proxy materials.From the 1934 House Report about the importance of Rule 14a-8: “Fair corporate suffrage is an important right that should attach to every equity security bought on a public exchange.”“Managements of properties owned by the investing public should not be permitted to perpetuate themselves by the misuse of corporate proxies. Insiders having little or no substantial interest in the properties they manage have often retained their control without an adequate disclosure of their interest and without an adequate explanation of the management policies they intend to pursue. Insiders have at times solicited proxies without fairly informing the stockholders of the purposes for which the proxies are to be used and have used such proxies to take from the stockholders for their own selfish advantage valuable property rights. Inasmuch as only the exchanges make it possible for securities to be widely distributed among the investing public, it follows as a corollary that the use of the exchanges should involve a corresponding duty of according to shareholders fair suffrage. For this reason the proposed bill gives the . . . Commission power to control the conditions under which proxies may be solicited with a view to preventing the recurrence of abuses which have frustrated the free exercise of the voting rights of stockholders.Investors Slam SEC Plan to Remove Best-Price RuleAtkins also is listening to the crypto bros who want to offer “tokenized securities” off exchanges and is hoping to eliminate a really basic rule that says “investors are entitled to the best price available for stocks they buy”Separately, DOJ Withdraws Antitrust Guidance for Proxy Advisory Industry - no antitrust protections for ISS (good!) but still can't do anything about the socialist NFL, MLB, NHL, NBA (bad!)Headliniest of the WeekDR: Popular breakfast chain closes half its restaurantsDR: The man leading Trump's RTO charge for government workers says he filmed a video in front of a blank wall to avoid work-from-home suspicionOffice of Personnel Management (OPM) Director Scott Kupor, the key driver of President Donald Trump's return-to-office agenda, admitted in a hot mic moment that he intentionally filmed a video in front of a blank wall while he was working from home so he wouldn't get blowback over working at home.“I was in my bedroom, but I was trying to find—because I knew someone was going to give me shit if like, they knew, ‘You were out of the office.' …I was trying to find something that was not recognizable as being in my house, basically. So I was just trying to find a plain corner with a white wall, which was not that easy to find.”Kupor was the first employee hired by Andreessen and Horowitz's venture capital firm, Andreessen Horowitz.MM: Flock Says It's “Taking a Break” From Responding to Media RequestsMM: Eric Schmidt is selling his superyachtWho is this headline for? Billionaire yacht buyers? Poor people who hate billionaires with yachts?Who Won the Week?DR: The women at L3Harris Shared Concerns About CEO's Behavior Years Before OusterMM: Joshua Ramer, the CEO at PeopleReturn (one of the last vestiges of diversity data in the US), whose newsletter today did the most Free Float thing I've seen anyone other than us do: they tracked a single Getty Image across SIX different company reportsThe image was called 1325876463 “Young Boy Leaping Into Father Arms In Playground”, mostly for sustainability reports because it's brown peopleThey found it in Danaher, Crown Castle, TD, Capital One, CSL Plasma, and Toyota EuropePredictionsDR: The meritocro-mano-sphere-o hires Christopher Kubasik again without any push back from anything or anyoneMM: We decide that, since everyone is trying to make companies immune from climate change lawsuits, that we just make CEOs personally immune for any behavior

In this episode of Taking Healthcare by Storm, Quality Insights Medical Director Dr. Jean Storm speaks with Alan Horowitz, Esq., RN,  an innovative healthcare lawyer who helps providers such as skilled nursing facilities, hospices, and home health agencies navigate the most complex regulatory challenges, bridging clinical care, government regulation, and legal advocacy with his deep understanding of both clinical issues and law.Alan breaks down how the nursing home survey and enforcement process works, why it can feel adversarial, and why appealing CMS actions is so difficult and time-consuming. He also highlights emerging challenges for long-term care providers—including marijuana use, medical aid in dying, and consent and capacity issues for residents with dementia—while stressing the importance of strong preparation and clinical leadership during surveys.If you have any topics or guests you'd like to see on future episodes, reach out to us on our website.The views and opinions expressed by the host and guests are their own and do not necessarily reflect the views, positions, or policies of Quality Insights. Publication number QI-082126-GK

In this episode of the 18Forty Podcast, we return to the topic of teshuva by talking to Mendel Horowitz, a Jerusalem-based psychotherapist, researcher, and author who introduces us to the notion of having a Good Enough Elul.In this episode we discuss:—What is the nature of the inner work we do over Elul?—How do our psychological and religious work overlap and interact?—How can we detach ourselves from external expectations and learn how to live comfortably in pursuit of our purest desires?Interview begins at 27:00.Tune in to hear a conversation about how we discover our most essential selves.Mendel Horowitz, M.S., is a Jerusalem-based psychotherapist, researcher, and author certified by the International Board for Certification of Group Psychotherapists. His research interests include group therapy and the intersection of masculinity, loneliness, and faith. He is a founding member of United Hatzalah's Psychotrauma & Crisis Response Unit and a member of the Public Outreach Committee of the American Group Psychotherapy Association. His essays have appeared in The New York Times, The Washington Post, The Jerusalem Post, JTA, The Forward, and the Jewish Journal, among other publications, and his professional writing has appeared in the International Journal of Group Psychotherapy.References:TurPirkei DeRabbi EliezerSong of Songs 6:3Psychoanalysis: The Impossible Profession by Janet MalcolmThe Examined Life: How We Lose and Find Ourselves by Stephen Grosz"I'm a Psychodynamic Therapist. Here's What That Means." by Mendel HorowitzGood Enough Elul on 18Forty"Good Enough Elul: What This Is and Is Not" by Mendel Horowitz For more 18Forty:NEWSLETTER: 18forty.org/joinSign up for Talmud DailyCALL: (212) 582-1840EMAIL: info@18forty.orgWEBSITE: 18forty.orgIG: @18fortyX: @18_fortyWhatsApp: join hereBecome a supporter of this podcast: https://www.spreaker.com/podcast/18forty-podcast--4344730/support.

⚠️ This episode discusses antidepressants, mental health treatment, withdrawal and sensitive topics around psychiatric medication. Please seek professional guidance before making any changes to your medication.This week I'm joined by Dr Mark Horowitz, clinical research fellow in psychiatry, co-author of the Maudsley Prescribing Guidelines, and one of the most important voices in the world right now on antidepressants and how to come off them safely.We explore the science behind antidepressants, what they actually do to the brain, and what nobody told you about coming off them.Dr Mark Horowitz is a clinical research fellow at University College London and North East London NHS Foundation Trust. He co-authored the Maudsley Deprescribing Guidelines, which have begun to change clinical guidance on antidepressant withdrawal worldwide. His research on tapering and withdrawal has been published in leading medical journals and has directly influenced NHS and international prescribing guidelines. He founded the National Prescribing Support Service and has trained clinicians at Outro Health in America in safer tapering approaches. He has personal experience of antidepressant withdrawal, which led him to dedicate his career to helping others through the same process.What we explore together:Why 1 in 6 people in England are on antidepressants — and whether we are overprescribingWhat antidepressants actually do to the brain and why the chemical imbalance theory is misleadingWhy the clinical trial data on antidepressants is far less impressive than most people realiseThe emotional blunting effect — what it is, why it happens and what to do about itWhy 85% of people recover from depression within 12 months with no intervention at allWhat withdrawal actually feels like — and why doctors so often get it wrongHow to taper safely and why doing it too fast causes so much unnecessary sufferingWhat the alternatives to antidepressants are and why they are rarely offered firstLove, Sarah Ann

Send us Fan MailDigital dentistry has transformed the way clinicians and laboratories work together—but effective communication is still the key to predictable outcomes.This week on Humpday Happy Hour™, Dr. Jeff Horowitz welcomes a very special guest—his son, Luke Horowitz—for a behind-the-scenes look at the world of digital design and laboratory communication. Drawing from his experience as a digital designer, Luke shares valuable insights into what dental labs need from clinicians to create successful restorations and how stronger communication can improve efficiency, reduce remakes, and enhance patient care.In this episode, we discuss common communication pitfalls between practices and labs, how digital workflows have changed the restorative process, and the details that can make the difference between a good case and a great one. Whether you're sending intraoral scans, planning complex restorations, or simply looking to strengthen your relationship with your lab, this conversation offers practical takeaways for every dentist embracing digital dentistry.Join us as we explore what your lab wishes every clinician knew—and how better collaboration leads to better outcomes.Join us live every Wednesday at 8:00 p.m. ET.#Dentistry #DigitalDentistry #DentalLab #DigitalWorkflow #RestorativeDentistry #DentistsInTheKnow #HumpdayHappyHour

Rabbi Avi Horowitz grew up in Scranton, PA. He studied in Baltimore in Yeshivat Ner Israel where he received his Semicha. He has a Masters in Philosophy from Johns Hopkins University in Maryland. He studied at YU at Azrieli where he received a Masters in Education. Rabbi Horowitz was a community rabbi and school principal for 23 years in Santiago, Chile. In 2019, he made Aliyah and started an elementary school in Israel. Now he's a tour guide and works for Moreshet Hakotel in the Old City. Rabbi Horowitz is also completing a Masters in Jewish History. He's married with six children and many grandchildren. He loves biking and tennis. www.rootsandroutesisrael.com/home-1-2https://www.maagalot.orgGems:If you can't explain complex ideas to laymen, then you can't understand what you're learning.Make sure to get a mentor.Knowing Hebrew as a Jew is completely different.Help students feel comfortable with the basics of the language and Tanach.Expose students to Israeli culture.Jewish education is about building relationships.Students need us to be the “guide on the side”. Education is passed down parents to children first.Return to the basics.Book: Wisdom of Jewish EducatorsFeaturing 100 of the most notable tips from educators who were featured on the podcast.TikvahTikvah focuses on Classical Jewish Education.Wellnesse Natural Personal Care ProductsWellnesse was founded by a mom who wanted healthier options for families. Check out my unique link!Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the show

Topics: Naftali Horowitz's Life Story | Mental Health | Addiction | Surrender.Guest: Naftali Horowitz | CEO at Rocklay Behavioral HealthContact Guest: Nh@rocklaybh.com | +1561-917-8355Rocklaybh.com | Rocklay.com-------------This Episode Is Sponsored By:• EL AL Airlines | Know who cares for you - Fly EL AL• United Refuah HealthShare | +1914-908-3300 https://UnitedRefuah.org• Luxury Kosher Villas | +1305-650-8830 | https://LuxuryKosherVillas.com-------------Host: Pinchus RaabCo-Host: Yiddy MoskowitzAdvertisements: ads@latesttalks.com

Living with chronic illness can feel like collecting diagnoses without getting real answers. Symptoms are treated one at a time, but the underlying causes can easily be missed. What if asking a different question is the first step toward feeling better? In this episode, I'm joined by Dr. Richard Horowitz, an internationally recognized Lyme disease expert and author of the new book Ending Chronic Illness. After caring for thousands of patients over more than four decades, he explains why many seemingly unrelated conditions share common underlying drivers—and why thinking like a medical detective may help uncover them. We discuss: Why treating the diagnosis isn't always the same as treating the problem—and how to start looking deeper How hidden infections, environmental toxins, gut health, and other overlooked factors can quietly drive chronic illness What new research may reveal about the links between infection, inflammation, and brain health How to begin uncovering what's really driving persistent symptoms Our bodies are constantly communicating with us. The challenge isn't that they're silent—it's that we haven't always known how to listen. Sometimes finding better answers begins with asking different questions. Continue Exploring If you'd like to explore Dr. Horowitz's work further, here are two great places to start: Take his Symptom Assessment Quiz to better understand what may be contributing to your symptoms. Subscribe to his Medical Detective Substack ****for ongoing insights into chronic illness, Lyme disease, and root-cause medicine. Interested in getting tested? Many of the lab tests discussed in this episode are available through Function, making it easier to get a more comprehensive picture of your health. View Show Notes From This Episode Sign up for Dr. Hyman's Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link Get Free Weekly Health Tips from Dr. Hymanhttps://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman's Weekly Longevity Journalhttps://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Healthhttps://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Resultshttps://drhyman.com/pages/hyman-hive This episode is brought to you by Timeline, Cozy Earth, Seatopia, Perfect Amino, BON CHARGE, and Made In. Support healthy aging and get up to 20% off when you subscribe on top of the new starting price of $79 at timeline.com/drhyman. Upgrade your sleep setup with cozyearth.com and enjoy 20% off  with code HYMAN. Find a cleaner source of seafood. Check out seatopia.fish and use code HYMAN for free shipping on your first order. Help fill protein gaps at bodyhealth.com and use code HYMAN20 for 20% off. Explore red light products at boncharge.com/hyman  and enjoy 15% off with code HYMAN. Explore kitchen essentials at madeincookware.com and save 10% off your first order with code HYMAN-HIVE. (0:00) Infections and toxins as root causes of chronic illness; Dr. Horowitz's background and journey to functional medicine (5:37) Discovering and treating various infections, toxins, and Dr. Hyman's personal health story (9:16) Root causes of chronic disease, inflammation, and testing for infections and toxins (15:11) Sponsor: Seatopia and PerfectAmino (16:42) Importance of diet, addressing multiple health factors, and autoimmune misdiagnosis (19:26) Role of infections, toxins, microbiome, and leaky gut in autoimmune diseases and inflammation (21:06) Treating underlying causes and neuroinflammation in chronic diseases (24:37) Nutritional deficiencies, COVID-19, and the importance of sleep in chronic illness management (30:19) Plant medicines, supplements, and dapsone in treating neuroinflammation, Lyme, and Alzheimer's (41:30) Use of methylene blue in treatment protocols (44:56) Sponsor: Bon Charge (45:58) Sponsor: Made In (46:43) Evolution of treatment protocols and six principal causes of inflammation (50:18) Importance of adrenal function and hormone treatment in chronic illness (52:17) Differential diagnosis vs. root cause analysis and root cause testing (56:38) Horowitz's questionnaire and protocols for treating chronic infections (58:39) Addressing mold-related health issues and Dr. Hyman's personal experience (1:01:01) Mold testing, detoxification, and controversies in treatment (1:07:47) Insurance challenges and HHS innovation grant for chronic illness research (1:09:04) Importance of root cause medicine and Mark Hyman's upcoming book on longevity (1:11:56) Personalized medicine, reversing Alzheimer's biomarkers, and research funding priorities (1:15:02) Influence of Buddhist principles and personal experiences with chronic illness (1:16:01) Hope for patients, resources for learning, and closing remarks

Do tanque e do porta-aviões do século XX aos drones baratos que destroem tanques de milhões, da IA que escolhe alvos em segundos (Lavender, Maven, Claude Mythos) aos robôs que já caminham no campo de batalha: neste episódio mergulhamos na maior revolução da tecnologia de guerra dos últimos 100 anos. Do “laboratório” da Ucrânia de drones FPV e fibra óptica, a IA transformou a decisão de matar em algoritmo, passando pela guerra de narrativas com deepfakes que ninguém mais sabe o que é real e o que está acontecendo. Guerra mais eficiente significa guerra melhor… ou só mais frequente e impessoal? Patronato do SciCast: 1. Patreon SciCast 2. Apoia.se/Scicast 3. Nos ajude via Pix também, chave: contato@scicast.com.br ou acesse o QRcode: Sua pequena contribuição ajuda o Portal Deviante a continuar divulgando Ciência! Contatos: contato@scicast.com.br https://twitter.com/scicastpodcast https://www.facebook.com/scicastpodcast https://www.instagram.com/PortalDeviante/ Fale conosco! E não esqueça de deixar o seu comentário na postagem desse episódio! Expediente: Produção Geral: Tarik Fernandes e André Trapani Equipe de Gravação: Luis Filipe Herdy, Gustavo Rebello, Gabriela Reciputti, Roberto Spinelli, Willian Spengler Citação ABNT: Scicast #692: Guerra sem humanos. Locução: Luis Filipe Herdy, Gustavo Rebello, Gabriela Reciputti, Roberto Spinelli, Willian Spengler. [S.l.] Portal Deviante, 20/07/2026. Podcast. Disponível em: https://www.deviante.com.br/podcasts/scicast-692 Imagem de capa: O drone russo KNV, com munição (verde) à frente e unidade de desenrolar de fibra óptica (em preto) atrás - Divulgação/Uchkuinik Referências e Indicações Sugestões de literatura: REBELLO, Gustavo. O uso militar de IAs: a ficção científica parou de ser inofensiva. Portal Deviante, 17 mar. 2026. Disponível em: https://www.deviante.com.br/noticias/o-uso-militar-de-ias-a-ficcao-cientifica-parou-de-ser-inofensiva/. Acesso em: 29 abr. 2026. HOROWITZ, Michael. Entrevista concedida a Tyler Rogoway et al. How America’s Shahed-136 Kamikaze Drone Clone Became an Indispensable Weapon of War. The War Zone, 9 abr. 2026. Disponível em: https://www.twz.com/news-features/how-americas-shahed-136-clone-became-an-indispensable-weapon-of-war. Acesso em: 29 abr. 2026. BERNSTEIN, Yuval et al. ‘Lavender’: The AI machine directing Israel’s bombing spree in Gaza. +972 Magazine, Tel Aviv, 3 abr. 2024. Disponível em: https://www.972mag.com/lavender-ai-israeli-army-gaza/. Acesso em: 29 abr. 2026. CUKOR, Drew et al. Project Maven: A Marine Colonel, His Team, and the Dawn of AI Warfare. Nova York: HarperCollins, 2026. (Trechos disponíveis em: https://www.wired.com/story/project-maven-katrina-manson-book-excerpt/). DEPARTMENT OF DEFENSE (EUA). Project Maven (Algorithmic Warfare Cross Functional Team). Washington, DC: DoD, 2017. Disponível em: https://en.wikipedia.org/wiki/Project_Maven. Acesso em: 29 abr. 2026. FEDOROV, Mykhailo. Ukraine overcomes critical obstacle to using fiber-optic drones. Defense Ministry of Ukraine, Kiev, 21 abr. 2026. Disponível em: https://www.msn.com/en-us/news/world/ukraine-overcomes-critical-obstacle-to-using-fiber-optic-drones/vi-AA21o96u. Acesso em: 29 abr. 2026. FOUNDATION ROBOTICS. Phantom MK-1 humanoid robot deployed to Ukraine for testing. Business Insider, 25 mar. 2026. Disponível em: https://www.businessinsider.com/foundation-humanoid-robot-soldier-ukraine-testing-2026-4. Acesso em: 29 abr. 2026. LEE, Lloyd. Foundation Wants to Build an Army of Humanoid Robot Soldiers. Business Insider, 25 mar. 2026. Disponível em: https://www.businessinsider.com/foundation-humanoid-robot-soldier-ukraine-testing-2026-4. Acesso em: 29 abr. 2026. SCHANAHAN, Jack. Inside the Pentagon’s Project Maven. YouTube, 2026. Disponível em: https://www.youtube.com/watch?v=Il-DWtgfqTk. Acesso em: 29 abr. 2026.WIRED. Meet the Gods of AI Warfare. Wired, 23 mar. 2026. Disponível em: https://www.wired.com/story/project-maven-katrina-manson-book-excerpt/. Acesso em: 29 abr. 2026. Sugestões de filmes: Decisão de Risco (2015, dir. Gavin Hood) – Eye in the Sky: Drone warfare, “human in the loop” Slaughterbots (2017, curta-metragem da Future of Life Institute) – 8 minutos que mostram enxames de drones autônomos Resistência (2023, dir. Gareth Edwards) – The Creator: Guerra futurista com IA e robôs humanoides Jogos de Guerra (1983) – WarGames: Clássico sobre IA e guerra nuclear automatizada (liga direto com o “Dead Hand”). Sugestões de vídeos: https://www.youtube.com/watch?v=fa8k8IQ1_X0 Sugestões de links: https://www.bloomberg.com/news/articles/2024-07-22/ubi-study-backed-by-openai-s-sam-altman-bolsters-support-for-basic-income https://www.anthropic.com/research/exploring-model-welfare https://www.anthropic.com/research/impact-software-development https://arxiv.org/pdf/2411.00986 Sugestões de games: Call of Duty: Modern Warfare II / III (2022-2023) – Uso realista de drones FPV, enxames e guerra eletrônica. DEFCON (2006, ou remakes modernos) – Simulação de guerra nuclear com sistemas automatizados de retaliação. Arma 3 com mods de drones ucranianos (comunidade) – Simulação tática de guerra assimétrica com FPV e fibra óptica. Six Days in Fallujah (2021) – Combate urbano moderno com IA e robótica See omnystudio.com/listener for privacy information.

Do tanque e do porta-aviões do século XX aos drones baratos que destroem tanques de milhões, da IA que escolhe alvos em segundos (Lavender, Maven, Claude Mythos) aos robôs que já caminham no campo de batalha: neste episódio mergulhamos na maior revolução da tecnologia de guerra dos últimos 100 anos. Do “laboratório” da Ucrânia de drones FPV e fibra óptica, a IA transformou a decisão de matar em algoritmo, passando pela guerra de narrativas com deepfakes que ninguém mais sabe o que é real e o que está acontecendo. Guerra mais eficiente significa guerra melhor… ou só mais frequente e impessoal? Patronato do SciCast: 1. Patreon SciCast 2. Apoia.se/Scicast 3. Nos ajude via Pix também, chave: contato@scicast.com.br ou acesse o QRcode: Sua pequena contribuição ajuda o Portal Deviante a continuar divulgando Ciência! Contatos: contato@scicast.com.br https://twitter.com/scicastpodcast https://www.facebook.com/scicastpodcast https://www.instagram.com/PortalDeviante/ Fale conosco! E não esqueça de deixar o seu comentário na postagem desse episódio! Expediente: Produção Geral: Tarik Fernandes e André Trapani Equipe de Gravação: Luis Filipe Herdy, Gustavo Rebello, Gabriela Reciputti, Roberto Spinelli, Willian Spengler Citação ABNT: Scicast #692: Guerra sem humanos. Locução: Luis Filipe Herdy, Gustavo Rebello, Gabriela Reciputti, Roberto Spinelli, Willian Spengler. [S.l.] Portal Deviante, 20/07/2026. Podcast. Disponível em: https://www.deviante.com.br/podcasts/scicast-692 Imagem de capa: O drone russo KNV, com munição (verde) à frente e unidade de desenrolar de fibra óptica (em preto) atrás – Divulgação/Uchkuinik Referências e Indicações Sugestões de literatura: REBELLO, Gustavo. O uso militar de IAs: a ficção científica parou de ser inofensiva. Portal Deviante, 17 mar. 2026. Disponível em: https://www.deviante.com.br/noticias/o-uso-militar-de-ias-a-ficcao-cientifica-parou-de-ser-inofensiva/. Acesso em: 29 abr. 2026. HOROWITZ, Michael. Entrevista concedida a Tyler Rogoway et al. How America's Shahed-136 Kamikaze Drone Clone Became an Indispensable Weapon of War. The War Zone, 9 abr. 2026. Disponível em: https://www.twz.com/news-features/how-americas-shahed-136-clone-became-an-indispensable-weapon-of-war. Acesso em: 29 abr. 2026. BERNSTEIN, Yuval et al. ‘Lavender': The AI machine directing Israel's bombing spree in Gaza. +972 Magazine, Tel Aviv, 3 abr. 2024. Disponível em: https://www.972mag.com/lavender-ai-israeli-army-gaza/. Acesso em: 29 abr. 2026. CUKOR, Drew et al. Project Maven: A Marine Colonel, His Team, and the Dawn of AI Warfare. Nova York: HarperCollins, 2026. (Trechos disponíveis em: https://www.wired.com/story/project-maven-katrina-manson-book-excerpt/). DEPARTMENT OF DEFENSE (EUA). Project Maven (Algorithmic Warfare Cross Functional Team). Washington, DC: DoD, 2017. Disponível em: https://en.wikipedia.org/wiki/Project_Maven. Acesso em: 29 abr. 2026. FEDOROV, Mykhailo. Ukraine overcomes critical obstacle to using fiber-optic drones. Defense Ministry of Ukraine, Kiev, 21 abr. 2026. Disponível em: https://www.msn.com/en-us/news/world/ukraine-overcomes-critical-obstacle-to-using-fiber-optic-drones/vi-AA21o96u. Acesso em: 29 abr. 2026. FOUNDATION ROBOTICS. Phantom MK-1 humanoid robot deployed to Ukraine for testing. Business Insider, 25 mar. 2026. Disponível em: https://www.businessinsider.com/foundation-humanoid-robot-soldier-ukraine-testing-2026-4. Acesso em: 29 abr. 2026. LEE, Lloyd. Foundation Wants to Build an Army of Humanoid Robot Soldiers. Business Insider, 25 mar. 2026. Disponível em: https://www.businessinsider.com/foundation-humanoid-robot-soldier-ukraine-testing-2026-4. Acesso em: 29 abr. 2026. SCHANAHAN, Jack. Inside the Pentagon's Project Maven. YouTube, 2026. Disponível em: https://www.youtube.com/watch?v=Il-DWtgfqTk. Acesso em: 29 abr. 2026.WIRED. Meet the Gods of AI Warfare. Wired, 23 mar. 2026. Disponível em: https://www.wired.com/story/project-maven-katrina-manson-book-excerpt/. Acesso em: 29 abr. 2026. Sugestões de filmes: Decisão de Risco (2015, dir. Gavin Hood) – Eye in the Sky: Drone warfare, “human in the loop” Slaughterbots (2017, curta-metragem da Future of Life Institute) – 8 minutos que mostram enxames de drones autônomos Resistência (2023, dir. Gareth Edwards) – The Creator: Guerra futurista com IA e robôs humanoides Jogos de Guerra (1983) – WarGames: Clássico sobre IA e guerra nuclear automatizada (liga direto com o “Dead Hand”).   Sugestões de vídeos: https://www.youtube.com/watch?v=fa8k8IQ1_X0 Sugestões de links: https://www.bloomberg.com/news/articles/2024-07-22/ubi-study-backed-by-openai-s-sam-altman-bolsters-support-for-basic-income https://www.anthropic.com/research/exploring-model-welfare https://www.anthropic.com/research/impact-software-development https://arxiv.org/pdf/2411.00986 Sugestões de games: Call of Duty: Modern Warfare II / III (2022-2023) – Uso realista de drones FPV, enxames e guerra eletrônica. DEFCON (2006, ou remakes modernos) – Simulação de guerra nuclear com sistemas automatizados de retaliação. Arma 3 com mods de drones ucranianos (comunidade) – Simulação tática de guerra assimétrica com FPV e fibra óptica. Six Days in Fallujah (2021) – Combate urbano moderno com IA e robótica

Today's guest is the genius and gem of a human- Dr. Richard Horowitz! Dr. Richard is board-certified internist, published researcher, pioneer in integrative medicine, and creator of the MSIDS (Multiple Systemic Infectious Disease Syndrome) model. He is also a 2x best selling author and one of the foundational doctor's helping people finally taking their health back from chronic disease. Today we discuss how his MSIDS model provides a systems-based framework for understanding how chronic infections, gut dysfunction, environmental toxins, immune dysregulation, mitochondrial dysfunction, hormonal imbalances, nutrient deficiencies, and other overlapping stressors contribute to persistent illness- and how you can help diagnose AND treat to get your health back. We also discuss various items such as:-Why some get Lyme and some don't-Why some get long COVID and some don't-What holds people back from healing-The foundations you need to ask yourself when trying to heal your bodySome random nuggets of wisdom in this podcast include:Lyme/Alzheimer's link: First published reversal of Alzheimer's biomarkers in a chronic Lyme patient after 9-week dapsone protocol. Bartonella identified as a major driver of long COVID, neuropsychiatric illness, and immune suppression; transmitted via cat scratches, fleas, mites, spider bites — not only tick bites. Emotional trauma / limbic dysfunction blocks biological recovery; limbic retraining (EMDR, DNRS, Primal Trust) is often required before other treatments become effective. Glutathione depletion enables COVID-19 (and other viruses) to replicate; blocking NF-κB and stimulating NRF2 pathways provided protection during the pandemic. Autism biomarkers (neurofilament light, P-tau) appear in children before symptom onset — same Alzheimer's markers found in adults. SO you can say- we get deep and nerdy!!Find Dr. Horowitz and his new book at:https://cangetbetter.com/His questionnaire hereFind his publications and research hereTo preorder his book - go hereMy Website & Work with Me: Instagram: ⁠⁠⁠⁠www.instagram.com/faithandfit⁠⁠⁠⁠⁠⁠⁠⁠www.upliftfitnutrition.com⁠⁠⁠⁠Email for coaching & phone consults: laceydunn@upliftfitnutrition.com & fitandfaith@gmail.comOrder my book ⁠"The Women's Guide to Hormonal Harmony" ⁠on amazon! 

As we have seen, even if wearing a Kippa cannot be defined as an outright Halachic obligation (except while praying, reciting Berachot, and eating), it is proper to ensure not to walk four Amot (cubits) with one's head uncovered. It is considered a special act of piety to avoid walking even shorter distances without a Kippa. The Maharshal (Rav Shlomo Luria, Poland, 1510-1573), surprisingly, writes that this entire concept applies only outdoors. Indoors, he writes, there is no need to wear a Kippa – even as a measure of piety – because there is a roof over one's head, and this suffices to remind him of G-d. Most later Poskim, however, including the Mishna Berura, disagreed, and maintained that one should wear a Kippa both outdoors and indoors. Is it recommended to wear a Kippa even while sleeping? From the Rambam's comments it appears, at least at first glance, that he assumed people did not wear a head-covering while sleeping. The Rambam ruled that the Birkot Ha'shahar – the series of morning blessings which we recite praising Hashem for certain phenomena we experience each morning – are recited only as we experience each phenomenon. For example, when one hears the crowing of the rooster, he recites "Ha'noten La'sechvi Bina…"; when one opens his eyes, he recites "Poke'ah Ivrim"; when one stands up from his bed, he recites, "Zokef Kefufim"; and so on. Toward the end of this sequential list of blessings, the Rambam mentions that upon putting on one's head-covering, he recites "Oter Yisrael Be'tifara." The Rambam seems to presume that people's heads were uncovered at night, and only in the morning they put on a covering. However, Rav Yisrael Bitan noted that the Rambam may have assumed that people slept with a small covering – like a Kippa – and then recited this Beracha when putting on their turban or larger hat. In any event, the Mishna Berura and others bring the teaching of the Shela (Rav Yeshaya Ha'levi Horowitz, d. 1630) that it is proper to sleep with a head-covering, though it seems clear that this was intended as a special measure of piety, and is not required. As a practical matter, it is very difficult to keep a Kippa on one's head during the night, and oftentimes it becomes difficult to find it in the morning. Certainly, if a man would end up waking up his wife early in the morning as he searches for Kippa, then he should not sleep with a Kippa. Some people avoid this problem by sleeping with a special hat that stays fastened on the head throughout the night. While this is commendable, it is certainly not required. Summary: One should wear a Kippa both indoors and outdoors. Some sources mention that one should sleep with a Kippa as a measure of special piety, though this is not required, especially given the practical difficulty entailed, though there are those who sleep with a cap that remains fastened on the head throughout the night.

Flock cameras are all the new rage. We have finally forgotten or lost interest in smart meters, Stingray, Dirtbox, PRISM, etc. Flock Safety systems are being installed without consultation of the public, and sometimes reinstalled without permission from local authorities. Sometimes they're randomly placed. These cameras and sensors are supposed to keep communities safer, but what they ultimately do, even according to law-enforcement, is create a dragnet surveillance grid in local communities. They've already been used to fine and jail people for crimes that they did not commit. Perhaps the worst part, but not unlike Axonius, Palantir, Waze, ShieldAI, and so forth, is that the two primary investors are the Peter Thiel group and Andreessen Horowitz, a company directly rooted in Israel. Furthermore, resistance to these cameras being installed is being labeled terrorism. It's also not out of the realm of possibility that many of the cameras that have been cut down, have been removed by law-enforcement, community officials, or the company itself in order to paint the technology as a victim of ignorant and violent citizens.*The is the FREE archive, which includes advertisements. If you want an ad-free experience, subscribe below.

durée : 01:28:01 - par : Aurélie Moreau - « Horowitz était un homme que l'on ne pouvait séparer de sa musique, et dont le jeu révélait les sentiments les plus profonds. Les sonorités qu'il produisait avaient une présence dramatique intense… » Témoignage de Murray Perahia pour Diapason. - équipe : Cécile Bonnet des Claustres, Ferdinand Prevaux - invités : Aurélie Moreau Productrice Vous aimez ce podcast ? Pour écouter tous les épisodes sans limite, rendez-vous sur Radio France

Writers of the Catskills: In Conversation with Mikhail HorowitzA series of self-portraits by Catskills' literary voices (Photo Credit: Dion Ogust)These are clips from my conversation on November 21, 2025, with Mikhail Horowitz, poet, writer, journalist, musician, satirist, performance artist and activist. Mikhail has written more than 1,000 poems (“maybe 25 are any good,” he says), along with book reviews, spoofs and satires. His work includes “Spoon River Apology,” performed at the Woodstock Community Center last June. Mikhail lived in the Town of Saugerties for 34 years, has been living in Woodstock for the past three years, and also lived in Woodstock briefly in the 1980s. In our conversation Mik described his creative process as relying on “a gift from the Muse.”Mik was introduced to me by my Woodstock friend, Frank Spinelli, who participated in the discussion, as did my Woodstock friend, Dion Ogust.They were both also photographing Mik as we talked.A condensed and edited version of this interview was published on December 25, 2025, in The Overlook, a nonprofit news outlet serving the Catskills communities of Hunter, Hurley, Olive, Saugerties, Shandaken, and Woodstock. and my interview with Mikhail can be heard on my podcast, “Tell Me What You're Reading”, available on Apple Podcasts,  Spotify  and wherever else you listen to podcasts.Howard Altarescu

A16z Podcast: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- In this commencement address to Columbia University's Fu Foundation School of Engineering and Applied Science Class of 2015, Ben Horowitz challenges some of the most common advice given to graduates. Rather than urging students to “follow their passion,” Horowitz argues that people should focus on developing their strengths and making meaningful contributions to the world. Drawing on stories from his own time at Columbia, the founding of technology companies, and investments in startups like Airbnb, he explores the importance of independent thinking, conviction, and pursuing ideas that others may initially dismiss. Along the way, Horowitz discusses technological progress, entrepreneurship, opportunity, and why he believes today's graduates are entering a world defined less by unprecedented challenges than by unprecedented possibilities. ee Resources: Follow Ben Horowitz on X: https://x.com/bhorowitz Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show on SpotifyListen to the a16z Show on Apple PodcastsFollow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

A16z Podcast In this commencement address to Columbia University's Fu Foundation School of Engineering and Applied Science Class of 2015, Ben Horowitz challenges some of the most common advice given to graduates. Rather than urging students to “follow their passion,” Horowitz argues that people should focus on developing their strengths and making meaningful contributions to the world. Drawing on stories from his own time at Columbia, the founding of technology companies, and investments in startups like Airbnb, he explores the importance of independent thinking, conviction, and pursuing ideas that others may initially dismiss. Along the way, Horowitz discusses technological progress, entrepreneurship, opportunity, and why he believes today's graduates are entering a world defined less by unprecedented challenges than by unprecedented possibilities. ee Resources: Follow Ben Horowitz on X: https://x.com/bhorowitz Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show on SpotifyListen to the a16z Show on Apple PodcastsFollow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this commencement address to Columbia University's Fu Foundation School of Engineering and Applied Science Class of 2015, Ben Horowitz challenges some of the most common advice given to graduates. Rather than urging students to “follow their passion,” Horowitz argues that people should focus on developing their strengths and making meaningful contributions to the world. Drawing on stories from his own time at Columbia, the founding of technology companies, and investments in startups like Airbnb, he explores the importance of independent thinking, conviction, and pursuing ideas that others may initially dismiss. Along the way, Horowitz discusses technological progress, entrepreneurship, opportunity, and why he believes today's graduates are entering a world defined less by unprecedented challenges than by unprecedented possibilities. ee Resources: Follow Ben Horowitz on X: https://x.com/bhorowitz Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show on SpotifyListen to the a16z Show on Apple PodcastsFollow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

THE PCE report is out – now the Fed has a decision. Micron blew away estimates – chip prices are soaring. The annual stress tests showing – all clear and banks respond. A great time to bring on our guest – Carley Garner of DeCarley Trading. NEW! DOWNLOAD THIS EPISODE'S AI GENERATED SHOW NOTES (Guest Segment) Carley Garner is a futures and options broker with DeCarley Trading, a division of Zaner Financial Services in Las Vegas, Nevada. With nearly two decades of experience, her commodity market analysis is often referenced on Jim Cramer’s Mad Money on CNBC, and she is a regular guest on Bloomberg Television’s Options Insight segment with Abigail Doolittle. You might also see her on the Cow Guy Close hosted by Scott Shellady on RFD-TV and “Futures” aired on Schwab Network. Garner is a regular contributor to TheStreet.com and its Pro service and is also a regular on the speaking circuit. She can be found at TradersEXPOs and MoneyShows throughout the country. Garner is also an award-winning author of commodity futures and options trading books. In addition to Trading Commodity Options with Creativity, Garner has authored Higher Probability Commodity Trading; A Trader’s First Book on Commodities (three editions); Currency Trading in the Forex and Futures Markets; and Commodity Options. She pens a monthly column for the long-running Technical Analysis of Stocks & Commodities Magazine. Her e-newsletters, The DeCarley Perspective and The Financial Futures Report have garnered a loyal following; she is also proactive in providing free trading education at www.DeCarleyTrading.com Follow @andrewhorowitz More information available on Horowitz & Company’s TDI Managed Growth Strategy Check this out and find out more at: http://www.interactivebrokers.com/ Stocks mentioned in this episode: (GLD), (SLV), (SPY)

Marc Horowitz has built a career across multiple industries—from energy derivatives trading and hedge funds to satellite imagery technology and custom jewelry. After retiring from trading in his early forties, Marc found himself searching for a new challenge that would allow him to build something meaningful. Today, he is the founder of Ilmeo, a jewelry company that transforms photos and impressions of loved ones into personalized keepsakes. In this episode, Marc shares lessons from finance, entrepreneurship, risk-taking, and the importance of creating products that carry emotional value. On this episode we talk about: How a career in energy derivatives trading led to financial independence Why retiring early isn't always the finish line people expect it to be The lessons Marc learned from helping build satellite imagery marketplace SkyFi The origin story behind Ilmeo and turning meaningful moments into a business Building customer-centric brands and navigating the challenges of e-commerce growth Top 3 Takeaways Financial success creates freedom, but fulfillment often comes from building something meaningful and lasting. If you don't know what your edge is, you're probably gambling—not investing. Strong relationships and a reputation for helping others become invaluable assets throughout your entrepreneurial journey. Notable Quotes "The harder you work, the luckier you get." "If you don't know what your edge is, you're gambling." "Money only exists so you can do things you enjoy, build memories, and live a meaningful life." Connect with Marc Horowitz: LinkedIn: https://www.linkedin.com/in/marc-horowitz-83a0b21aa/ Website: https://ilmiojewelry.com/ Email: marc@ilmio.com A Word from Our Sponsors: Today's episode is brought to you by our valued sponsors. Their support helps us continue bringing you conversations with entrepreneurs, investors, and innovators who are finding unique ways to create wealth and build meaningful businesses. Be sure to check out the sponsors in the episode description and support the brands that make this show possible. - Are you ready to start your own creatorjourney and make it big? Visitwww.fanvue.com today and launch yourcareer! - To learn more about Mode Mobile and its investor community, go to https://invest.modemobile.com/travismakesmoney -Travis Makes Money is made possible by High Level – the All-In-One Sales & Marketing Platform built for agencies, by an agency.Capture leads, nurture them, and close more deals—all from one powerful platform.Get an extended free trial at gohighlevel.com/travis Learn more about your ad choices. Visit megaphone.fm/adchoices

Mace and Jeff put Matt Walsh's antidepressant episode under the clinical microscope — and it does not pass the functional impairment test. They break down the 2022 Molecular Psychiatry umbrella review that dismantled the low-serotonin narrative, explain why that finding doesn't indict SSRIs as a category, and make the case that the “chemical imbalance” pitch was always more pharmaceutical advertising than clinical science. They also tackle what functional impairment actually means in diagnosis, the gender disparity in antidepressant prescribing, whether the SSRI-to-mass-violence argument is causal or just really committed to showing up in the same sentence, and what clinicians should actually be telling clients about medications they can't fully explain. For anyone who has ever explained serotonin to a client and quietly wondered if they knew what they were talking about: this one's for you. Music: “Machine Heart – Instrumental version” by Icarus. Licensed via Artlist Pro License #JeMO9k. Bielefeldt, A. Ø., Danborg, P. B., & Gøtzsche, P. C. (2016). Precursors to suicidality and violence on antidepressants: systematic review of trials in adult healthy volunteers. Journal of the Royal Society of Medicine, 109(10), 381–392. https://doi.org/10.1177/0141076816666805 Brody, D. J., & Gu, Q. (2020). Antidepressant use among adults: United States, 2015–2018. NCHS Data Brief, No. 377. https://www.cdc.gov/nchs/products/databriefs/db377.htm Chua, K. P., Volerman, A., Zhang, J., Hua, J., & Conti, R. M. (2024). Antidepressant dispensing to US adolescents and young adults: 2016–2022. Pediatrics, 153(3), e2023064245. https://doi.org/10.1542/peds.2023-064245 Healy, D., & Mangin, D. (2024). Post-SSRI sexual dysfunction: barriers to quantifying incidence and prevalence. Epidemiology and Psychiatric Sciences, 33, e44. https://doi.org/10.1017/S2045796024000441 Kuehner, C. (2017). Why is depression more common among women than among men? The Lancet Psychiatry, 4(2), 146–158. https://doi.org/10.1016/S2215-0366(16)30263-2 Moncrieff, J., Cooper, R. E., Stockmann, T., Amendola, S., Hengartner, M. P., & Horowitz, M. A. (2023). The serotonin theory of depression: a systematic umbrella review of the evidence. Molecular Psychiatry, 28, 3243–3256. https://doi.org/10.1038/s41380-022-01661-0 Salk, R. H., Hyde, J. S., & Abramson, L. Y. (2017). Gender differences in depression in representative national samples: Meta-analyses of diagnoses and symptoms. Psychological Bulletin, 143(8), 783–822. https://doi.org/10.1037/bul0000102 Stone, M., Laughren, T., Jones, M. L., Levenson, M., Holland, P. C., Hughes, A., Hammad, T. A., Temple, R., & Rochester, G. (2009). Risk of suicidality in clinical trials of antidepressants in adults: analysis of proprietary data submitted to US Food and Drug Administration. BMJ, 339, b2880. https://doi.org/10.1136/bmj.b2880

What if some people diagnosed with chronic fatigue, fibromyalgia, autoimmune disease, anxiety, or even early Alzheimer's are actually dealing with an underlying infection that was never properly identified? Today, I'm sharing my conversation with Dr. Richard Horowitz, a board-certified internist who has treated more than 13,000 patients with Lyme and tick-borne disease over the last four decades, many of whom had already seen countless doctors and collected diagnoses like chronic fatigue syndrome, fibromyalgia, depression, anxiety, multiple sclerosis, and early dementia before discovering Lyme may have been part of the picture. Dr. Horowitz calls Lyme "the great imitator" because its symptoms can overlap with so many other conditions, and since 2016, Dr. Horowitz has published 11 papers on treatment approaches. In one of his latest studies, he and his colleagues explored a possible connection between Lyme disease and Alzheimer's biomarkers, reporting major improvements in certain inflammatory and cognitive-related markers after treatment. We discuss his broader "MSIDS" model, which looks at chronic illness through a much wider lens. Instead of looking for one single cause, the model examines multiple overlapping factors that may contribute to illness, including infections, toxins, gut dysfunction, nutrient deficiencies, sleep issues, immune imbalance, and inflammation. In this podcast, Dr. Horowitz and I discuss: Why Lyme disease is called "the great imitator" and how it can resemble chronic fatigue syndrome, fibromyalgia, multiple sclerosis, anxiety, depression, and Alzheimer's disease The often-overlooked migratory pain that is one of the hallmark symptoms of chronic Lyme The Lyme symptom questionnaire, which he developed and validated on 6,400 patients How research from Johns Hopkins and other universities changed our understanding of Lyme as a persistent infection Why Dr. Horowitz began using drugs like dapsone and rifampin in Lyme treatment protocols His published research on dapsone combination therapy and the improvements he has observed in patients His recent findings on Lyme disease and Alzheimer's biomarkers, including reductions in tau217 levels Dr. Horowitz's unique MSIDS model and the many overlapping factors that may drive chronic illness Why chronic illness rates continue rising and what conventional medicine may still be missing Why Dr. Horowitz believes recovery is possible, even for patients who have been sick for years  

Jeremy Horowitz, the Managing Partner of Because Ventures and CEO of CoCo AI, adds his page to the Marketing Playbook. Hear how to differentiate your brand, how to use AI as an efficiency tool, why business owners make the best business buyers, what to look for when investing in a business, and Jeremy's passions for sports & entrepreneurship. Connect with Jeremy at Because.Ventures, My-CoCo.AI, on LinkedIn, and his Let's Buy a Biz! newsletter

#489> To purchase the book:https://mosaicapress.com/product/abled/?sld=seforimchatter use code CHATTER for 15% off> To join the SeforimChatter WhatsApp community: https://chat.whatsapp.com/DZ3C2CjUeD9AGJvXeEODtK> To join the SeforimChatter WhatsApp status: https://wa.me/message/TI343XQHHMHPN1>  To support the podcast or to sponsor an episode follow this link: https://seforimchatter.com/support-seforimchatter/or email seforimchatter@gmail.com (Zelle/QP this email address)Support the show

In this episode of New Frontiers in Functional Medicine, Richard Horowitz joins Kara Fitzgerald to explore the connection between persistent infections, inflammation, and chronic disease. The discussion highlights emerging research linking Borrelia burgdorferi (Lyme disease) to amyloid production and Alzheimer's biomarkers, along with the clinical implications of Dr. Horowitz's MSIDS model. Topics include biofilm persistence, co-infections, treatment resistance, and multi-targeted strategies for addressing complex, chronic conditions such as Lyme disease, ME/CFS, fibromyalgia, and long COVID. This episode offers clinicians a more integrated framework for evaluating and managing treatment-resistant patients. Full show notes + references: https://www.drkarafitzgerald.com/fxmed-podcast/ GUEST DETAILS Richard Horowitz is a board-certified internist and founder of the Hudson Valley Healing Arts Center. For more than 40 years, he has treated over 13,000 patients with Lyme disease and complex chronic illness using both conventional and integrative approaches. Dr. Horowitz is the developer of dapsone combination therapy and author of the New York Times bestsellers Why Can't I Get Better? and How Can I Get Better? His newest book, Ending Chronic Illness, explores how his MSIDS model may apply to many chronic diseases beyond Lyme, offering a broader systems-based framework for diagnosis and treatment. https://cangetbetter.com/ THANKS TO OUR DIAMOND SPONSORS Time—Line Nutrition: http://pro.timeline.com/ DUTCH: https://dutchtest.com/for-providers Biotics Research: https://www.bioticsresearch.com/ THANKS TO OUR GOLD SPONSORS Equelle: http://equelle.com Fullscript Journeys: http://www.fullscript.com/journeys-kara CONNECT with DrKF Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Younger You Practitioner Training Program: https://www.drkarafitzgerald.com/trainingyyi/ Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

In this episode, Kelly interviews Dr. Mark Horowitz, a psychiatrist and author, about the long-term impacts of antidepressants, the challenges of coming off these medications, and the future of deprescribing. This conversation sheds light on why many people remain trapped on these drugs and what can be done to change this reality. Key Topics: The origins of Dr. Horowitz's involvement in deprescribing and his personal experience The widespread use of antidepressants in America and the long-term health risks How withdrawal symptoms can be mistaken for a need to stay on medication The insidious side effects of antidepressants, including weight gain, sexual dysfunction, and increased risk of fractures The lack of long-term studies and regulatory oversight on the effects of antidepressants The importance of informed consent and alternative treatment options How marketing and legal factors influence prescribing habits Strategies for safe tapering and support resources for deprescribing The evolving awareness and cultural shift regarding antidepressant risks Deprescribing book https://markhorowitz.org/ Listen to my Tedx Talk: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Why we need adult sex ed⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Take my ⁠⁠⁠⁠⁠⁠⁠⁠⁠Adult Sex Ed Master Class:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠My Website⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Interested in my sexual health and hormone clinic? ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Waitlist is open⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ To learn more about Via vaginal moisturizer from Solv Wellness, visit ⁠⁠⁠⁠⁠via4her.com⁠⁠⁠⁠⁠ and get 20% off your first order. For an additional $5 off, use coupon code DRKELLY5. Clinicians can request patient materials or samples at ⁠⁠⁠⁠⁠hcp.solvwellness.com⁠⁠⁠⁠⁠. Thanks to our sponsor ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Midi Women's Health⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Designed by midlife experts, delivered by experienced clinicians, covered by insurance.Midi is the first virtual care clinic made exclusively for women 40+. Evidence-based treatments. Personalized midlife care.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.joinmidi.com⁠ Learn more about your ad choices. Visit podcastchoices.com/adchoicesSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode, Kelly interviews Dr. Mark Horowitz, a psychiatrist and author, about the long-term impacts of antidepressants, the challenges of coming off these medications, and the future of deprescribing. This conversation sheds light on why many people remain trapped on these drugs and what can be done to change this reality. Key Topics: The origins of Dr. Horowitz's involvement in deprescribing and his personal experience The widespread use of antidepressants in America and the long-term health risks How withdrawal symptoms can be mistaken for a need to stay on medication The insidious side effects of antidepressants, including weight gain, sexual dysfunction, and increased risk of fractures The lack of long-term studies and regulatory oversight on the effects of antidepressants The importance of informed consent and alternative treatment options How marketing and legal factors influence prescribing habits Strategies for safe tapering and support resources for deprescribing The evolving awareness and cultural shift regarding antidepressant risks Deprescribing book https://markhorowitz.org/ Listen to my Tedx Talk: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Why we need adult sex ed⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Take my ⁠⁠⁠⁠⁠⁠⁠⁠⁠Adult Sex Ed Master Class:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠My Website⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Interested in my sexual health and hormone clinic? ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Waitlist is open⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ To learn more about Via vaginal moisturizer from Solv Wellness, visit ⁠⁠⁠⁠⁠via4her.com⁠⁠⁠⁠⁠ and get 20% off your first order. For an additional $5 off, use coupon code DRKELLY5. Clinicians can request patient materials or samples at ⁠⁠⁠⁠⁠hcp.solvwellness.com⁠⁠⁠⁠⁠. Thanks to our sponsor ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Midi Women's Health⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Designed by midlife experts, delivered by experienced clinicians, covered by insurance.Midi is the first virtual care clinic made exclusively for women 40+. Evidence-based treatments. Personalized midlife care.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.joinmidi.com⁠ Learn more about your ad choices. Visit podcastchoices.com/adchoices

In Ilona Bannister's Five, five strangers wait on a train platform. One will die in the next five minutes but only one person knows: the reader. In Anthony Horowitz's A Deadly Episode, his real 2018 novel The Word is Murder becomes a fictional film adaptation with one problem: the actor playing the protagonist is dead. Today's episode features conversations on metafiction with both authors. First, Bannister talks to NPR's Ayesha Rascoe about writing a novel with a five-minute timespan. Then, Horowitz talks to NPR's Scott Simon about poking fun at true crime — with a novel about true crime.To listen to Book of the Day sponsor-free and support NPR's book coverage, sign up for Book of the Day+ at plus.npr.org/bookofthedaySee pcm.adswizz.com for information about our collection and use of personal data for sponsorship and to manage your podcast sponsorship preferences.NPR Privacy Policy

In this episode of Resiliency Radio with Dr. Jill, Dr. Jill Carnahan welcomes Dr. Richard Horowitz, one of the world's leading experts in chronic illness and tick-borne disease, to discuss the groundbreaking science behind the MSIDS model and its implications for conditions ranging from Lyme disease to Alzheimer's. Dr. Horowitz shares revolutionary findings connecting chronic infections, inflammation, environmental toxins, gut dysfunction, and immune imbalance to persistent disease. He also discusses a surprising breakthrough involving Alzheimer's biomarkers and chronic Lyme treatment using his innovative dapsone protocol. This powerful conversation explores how addressing the root causes of inflammation and chronic illness may transform the future of medicine and offer hope for patients struggling with complex, unresolved health conditions.

Ben Horowitz shares lessons from building and scaling companies, drawing on his experience as a founder and CEO. He explains why a founder's primary responsibility comes down to one thing: delivering the right product at the right time. The conversation covers how strategy actually develops in practice, why a company's story is inseparable from its strategy, and how founders should think about hiring, fundraising, and decision-making in fast-changing environments. Horowitz also discusses how AI is reshaping teams, the increasing importance of creativity and relationships, and why roles may evolve toward more generalist “builders.” He also reflects on navigating uncertainty, the reality of pivots, and why defensibility still comes down to solving hard problems and building meaningful relationships with customers.   Resources: Follow Ben Horowitz on X: https://x.com/bhorowitz Follow Speedrun on YouTube: https://x.com/speedrun Apply for Speedrun: https://speedrun.a16z.com/ Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show on SpotifyListen to the a16z Show on Apple PodcastsFollow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

David Ulevitch speaks with Ben Horowitz about what it means to lead the technology industry at scale, and the responsibilities that come with it. Following the firm's largest-ever fundraise, they discuss how venture capital, technology, and national strategy are increasingly intertwined. The conversation covers America's role in the next technological revolution, from AI to advanced manufacturing, and why maintaining technological leadership is critical not just for economic growth, but for global influence. Horowitz also shares his perspective on working with government, supporting national security innovation, and building systems that give more people the opportunity to contribute. They also discuss how venture capital is evolving, the shift toward larger firms and specialized strategies, and why optimism about technology, and its potential to improve lives, remains essential even amid growing skepticism.   Resources: Follow Ben Horowitz on X: https://x.com/bhorowitz Follow David Ulevitch on X: https://x.com/davidu   Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show on SpotifyListen to the a16z Show on Apple PodcastsFollow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

If you enjoy this episode, we're sure you will enjoy more content like this on The Occult Rejects.  In fact, we have curated playlists on occult topics like grimoires, esoteric concepts and phenomena, occult history, analyzing true crime and cults with an occult lens, Para politics, and occultism in music. Whether you enjoy consuming your content visually or via audio, we've got you covered - and it will always be provided free of charge.  So, if you enjoy what we do and want to support our work of providing accessible, free content on various platforms, please consider making a donation to the links provided below.  Thank you and enjoy the episode!Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Cash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejects1. Patel, A. K., et al. *Physiology, Sleep Stages*. StatPearls / NCBI Bookshelf, 2024.2. Jensen, O., & Mazaheri, A. “Shaping Functional Architecture by Oscillatory Alpha Activity: Gating by Inhibition.” *Frontiers in Human Neuroscience*, 2010.3. Cavanagh, J. F., & Shackman, A. J. “Frontal Midline Theta Reflects Anxiety and Cognitive Control: Meta-Analytic Evidence.” *Journal of Physiology-Paris*, 2015.4. Axmacher, N., et al. “Cross-Frequency Coupling Supports Multi-Item Working Memory in the Human Hippocampus.” *PNAS*, 2010.5. Lacaux, C., et al. “Sleep Onset Is a Creative Sweet Spot.” *Science Advances*, 2021.6. Horowitz, A. H., et al. “Targeted Dream Incubation at Sleep Onset Increases Post-Sleep Creative Performance.” *Scientific Reports*, 2023.7. Caporro, M., et al. “Functional MRI of Sleep Spindles and K-Complexes.” *Clinical Neurophysiology*, 2012.8. Ng, T., et al. “Bayesian Meta-Analysis Reveals the Mechanistic Role of Slow Oscillation-Spindle Coupling in Sleep-Dependent Memory Consolidation.” *eLife*, 2025.9. Datta, K., et al. “Electrophysiological Evidence of Local Sleep During Yoga Nidra Practice in Young Male Volunteers.” *Frontiers in Neurology*, 2022.10. Jensen, M. P., et al. “Brain Oscillations, Hypnosis, and Hypnotizability.” *American Journal of Clinical Hypnosis*, 2015.11. Huels, E. R., et al. “Neural Correlates of the Shamanic State of Consciousness.” *Frontiers in Human Neuroscience*, 2021.12. Ingendoh, R. M., et al. “Binaural Beats to Entrain the Brain? A Systematic Review...” *PLOS ONE*, 2023.13. Páez, A., et al. “Sleep Spindles and Slow Oscillations Predict Cognition and Biomarkers of Neurodegeneration in Mild to Moderate Alzheimer's Disease.” *Alzheimer's & Dementia*, 2025.14. Askitopoulou, H. “Sleep and Dreams: From Myth to Medicine in Ancient Greece.” *Journal of Anesthesia History*, 2015.15. Pavli, A. “Asclepieia in Ancient Greece: Pilgrimage and Healing.” *Journal of Integrative Medicine and Research*, 2024.Also want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. Now let me introduce the rest of the panel and guests.

Today on Scope Conditions: when the bombs don't go off, the war isn't over.We tend to think of peace as beginning when the bombs stop falling. But as our guest today shows us, this is only half the story. Over the course of the Vietnam War, the United States engaged in massive bombing in Cambodia. Between 1965 and 1973, the U.S. dropped 500,000 tons of explosives there — more than the combined weight of every man, woman, and child in the country. Dr. Erin Lin, an Associate Professor of Political Science at the Ohio State University, set out to understand the continued impacts of this cataclysmic bombing campaign on Cambodian society. A landmark 2011 study had given us a partial answer: it had concluded that US bombing had no measurable long-term effects on economic outcomes in Southeast Asia. For years, that finding set the terms of the debate.In her award-winning book, When the Bombs Stopped: The Legacy of War in Rural Cambodia, published by Princeton University Press, Erin pushes back. She argues that those analyses were looking at the wrong level — that district-level aggregates conceal devastating effects on individual households and farms. More than that, they were looking at only half the intervention. It's the bombs that didn't detonate — an estimated 26 million cluster munitions still embedded in the soil — that are shaping life today in rural Cambodia.Erin spent years farming alongside families, combing through declassified military records, and building some of the most granular data ever assembled on the American bombing campaign. Her creative multi-method research design allows her to trace the dramatic long-term consequences of unexploded ordinance for the economic livelihood of Cambodian farmers.We talk with Erin about the many ironies laced through her findings: that cluster munitions are most likely to fail in soft, fertile soil, meaning Cambodia's most agriculturally valuable land is also its most contaminated; that bomb contamination can paradoxically shield farmers from predatory land seizures by political elites; and that unexploded ordnance, rather than forging solidarity among those living with it, tends to deepen ethnic divisions within villages.We hope you learn from this conversation. To stay informed about future episodes, follow us on X and Bluesky @scopeconditions and check out our website, scopeconditionspodcast.com, where you can also find references to all the academic works we discuss. And if you like the show, please rate and review us on Apple Podcasts or Spotify.We note that we recorded this interview before the recent US-Israeli war with Iran. Now, here's our conversation with Erin Lin.Works cited in this episodeBiddle, Steven. 2004. Military Power: Explaining Victory and Defeat in Modern Battle. Princeton University Press.Brooks, Rosa. 2014. “Cross-Border Targeted Killings: ‘Lawful but Awful'?” Harvard Journal of Law and Public Policy 38:233–50.________. 2014. “Drones and the International Rule of Law.” Ethics & International Affairs 28(1):83–103. ________. 2016. How Everything Became War and the Military Became Everything: Tales from the Pentagon. Simon and Schuster.Horowitz, Michael C. 2010. The Diffusion of Military Power. Princeton University Press.Lyall, Jason, and Isaiah Wilson. 2009. “Rage against the Machines: Explaining Outcomes in Counterinsurgency Wars.” International Organization 63(1):67–106.Reiter, Dan, and Allan C. Stam. 2010. Democracies at War. Princeton University Press.Pape, Robert A. 2014. Bombing to Win: Air Power and Coercion in War. Cornell University Press.Schelling, Thomas. 2008. Arms and Influence. Yale University Press.Sheehan, Neil. 1971. “Should We Have War Crime Trials?” New York Times Book Review. 

To get live links to the music we play and resources we offer, visit www.WOSPodcast.comThis show includes the following songs:Jill Detroit - Mother and Daughter FOLLOW ON SPOTIFYBeth McDonald - My Baby FOLLOW ON SPOTIFYEd & Carol Nicodemi - A Mother's Love Reimagined FOLLOW ON SPOTIFYChrista Wells - Oh Your Love FOLLOW ON SPOTIFYMina Reya - The Only Direction FOLLOW ON SPOTIFYKaren Turner - Jacaranda FOLLOW ON SPOTIFYJeannine Barr - Choose Love FOLLOW ON SPOTIFYDoreen Pinkerton - Tides (flute) FOLLOW ON SPOTIFYMarsh Gothic - Manifestation FOLLOW ON SPOTIFYAnanda - Mother's Lullabye FOLLOW ON SPOTIFYCarlene Thissen - Mama In Your Heart FOLLOW ON SPOTIFYSyrendip - Mother FOLLOW ON SPOTIFYJenny Van Alstyne - Let Love Carry Us FOLLOW ON SPOTIFYDr. Sue Horowitz - Teach You In Time FOLLOW ON SPOTIFYHarmonious Wail - Dat Dere FOLLOW ON SPOTIFYFor Music Biz Resources Visit www.FEMusician.com and www.ProfitableMusician.comTry our Sponsor Songtools for 50% off with code PM50 at http://profitablemusician.com/SongTools Visit our Sponsor Ed & Carol Nicodemi at edandcarolnicodemi.com Visit our Sponsor Susan Tamoosh at susantahmoosh.comVisit our Sponsor Nick & Ashley at nickandashleysanders.comVisit www.wosradio.com for more details and to submit music to our review board for consideration.Visit our resources for Indie Artists: https://www.wosradio.com/resourcesBecome more Profitable in just 3 minutes per day. http://profitablemusician.com/join

Today's show features: - Stephen M. Rowley, President of Cox Automotive - Aharon Horwitz is the Co-Founder and CEO of Fullpath - David Boice, Co-Founder and CEO of Team Velocity - Ron Almeida, General Manager of Colonial Ford of Plymouth This episode is brought to you by: Zurich – Zurich delivers The Zurich Advantage to dealerships nationwide by combining comprehensive F&I products, consultative training, revenue‑generating programs, and wealth‑building profit participation strategies. Grounded in our mission to provide clarity, confidence, and certainty, we help dealers protect what matters, strengthen performance, and build a legacy for the road ahead. Learn more at https://carguymedia.com/4cNTwyu Team Velocity – Team Velocity helps dealerships deliver faster, smarter, and more connected customer experiences through fully integrated platform technology. From websites and advertising to retention solutions and a native CDP, Team Velocity provides the tools dealerships need to succeed in every stage of the customer journey. Visit https://teamvelocitymarketing.com/ for more information or to request a demo. Check out Car Dealership Guy's stuff: CDG Circles ➤ https://cdgcircles.com/ CDG News ➤ https://news.dealershipguy.com/ CDG Jobs ➤ https://jobs.dealershipguy.com/ CDG Recruiting ➤ https://www.cdgrecruiting.com/ My Socials: X ➤ ⁠https://www.twitter.com/GuyDealership⁠ Instagram ➤ ⁠https://www.instagram.com/cardealershipguy/⁠ TikTok ➤ ⁠https://www.tiktok.com/@guydealership⁠ LinkedIn ➤⁠ https://www.linkedin.com/company/cardealershipguy/⁠ Threads ➤ ⁠https://www.threads.net/@cardealershipguy⁠ Facebook ➤⁠ https://www.facebook.com/profile.php?id=100077402857683⁠

Can you influence what you dream about tonight? Are you spending years of your life in a world you don’t recall? Can nightmares be manipulated as a therapy? Are dreams sometimes predictive of changes in your health before you become aware of them? Join Eagleman with Adam Haar Horowitz, a neuroscientist and dream engineer who spends his working days trying to help people during their night time.

Newt talks with Michael Horowitz, senior fellow at the Council on Foreign Relations and Richard Perry Professor at the University of Pennsylvania. They discuss the AI company Anthropic and its model, Claude Gov, which is the first AI model used on classified systems. A recent meeting between Secretary Hegseth and Anthropic's CEO Dario Amodei at the Pentagon failed to reach an agreement on assurances against the use of the model for surveillance or autonomous weapons, leading Anthropic to sue the Department of Defense over being labeled a supply chain risk. Horowitz discusses the slow adoption of AI in the military, attributing it to the U.S. military's historical reluctance to change due to its current superiority. He outlines three AI applications in the military: logistics, intelligence surveillance, and autonomous weapon systems, emphasizing the potential for AI to transform warfare. They also discuss OpenAI working with the military. Horowitz sees AI as an inevitable part of military evolution, comparable to past technological revolutions like electricity.See omnystudio.com/listener for privacy information.