Podcasts about Calico

Welcome back to the Abundance Hack Podcast, where we dive deep into the alchemy of turning life's challenges into gold and the magic of true embodiment. In this follow-up to a previous, thought-provoking episode, host Niajae sits down once again with sacred intimacy coach Cheri' Calico to explore the nuanced layers of modern relationships. After stirring up some intense reactions last time, they're here to go even deeper, unpacking topics like the resurgence of traditionalism, the real meaning behind the “soft life” trend, and the disconnects that arise between men's and women's expectations in relationships. Through candid conversations, Niajae and Cheri' tackle everything from emotional safety, the survival-based dynamics many couples unconsciously operate in, to the ways unchecked childhood wounds, especially around the mother archetype, can impact partnership today. They also discuss powerful tools like relationship agreements, inspired by practices in the kink and non-monogamy communities, and highlight the importance of clarity, healthy conflict resolution, and upholding authenticity on both sides. Whether you're curious about reparenting your inner child, identifying dysfunction loops, or learning how to create a sacred union, this episode is packed with insights, actionable advice, and plenty of soul. Get ready to challenge old beliefs and open your mind to healthier, more connected ways of loving. Get in touch with Cheri' https://bit.ly/ConnectwithCheri Follow her on Instagram https://www.instagram.com/chericalico   Ready to reparent your inner child and become an emotionally safe partner? The Healthy Love Healing App offers guided meditations, journal prompts, inner child healing, shadow work, and so much more to support your emotional growth and healing journey.

Our friend Ruby Karp has proposed one of our most wholesome adventures yet: a tour through a world of adorable animal figurines, cute playhouses, and fabulous accessories. But just like Sylvanian Drama, we will find the theatrics. Ruby's on Instagram and TikTok @rubykarp, and you can see her show now through May 3 at Soho Playhouse in New York. Can't get enough of Ruby? Neither can we: make sure to check out her episode of Worse Than You! One of Us is hosted and produced by Chris Renfro and Fin Argus. It's executive produced by Myrriah Gossett and Erica Getto for Good Get. Myrriah Gossett is our sound designer, and our theme music is produced by Fin Argus and Brendan Chamberlain-Simon. Our show art was drawn by Fin Argus, and photographed by Mike and Matt McCarty. You can follow One Of Us on Instagram and TikTok at @oneofus.pod. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Dr. Aubrey de Grey reveals why reversing aging may be easier than slowing it down in this mind-expanding conversation that challenges conventional wisdom about human longevity. The renowned biomedical gerontologist outlines his damage repair approach that's gaining mainstream scientific acceptance after initial skepticism.The financial landscape of longevity research has dramatically transformed, with billions flowing into the space. Dr. de Grey provides an insider's assessment of major players including HEvolution (Saudi-backed), Altos Labs (Bezos-funded), Calico (Google-funded) and Retro Biosciences (Sam Altman's venture), offering candid insights about which approaches show the most promise and why Google's Calico has struggled despite substantial resources.Regulatory innovation emerges as a crucial accelerator for progress. Montana's groundbreaking expansion of Right to Try legislation now allows anyone to access treatments that have passed FDA safety trials, while special economic zones like Prospera in Honduras are creating regulatory environments specifically designed for biomedical innovation. These developments could create the competitive pressure needed to modernize traditional regulatory structures worldwide.At the LEV Foundation, Dr. de Grey is conducting a thousand-mouse study combining four different damage repair interventions in middle-aged mice, aiming for a full year of life extension—far beyond the four months typically achieved. Unlike conventional approaches that rely on dietary modifications, this ambitious project incorporates advanced cell and gene therapies that target multiple forms of age-related damage simultaneously.Looking forward, Dr. de Grey offers his characteristic probabilistic prediction: a 50-50 chance of reaching "longevity escape velocity" within 12-15 years. This would enable taking 60-year-olds and rejuvenating them enough that they wouldn't be biologically 60 again for another 20 years, during which time further advances would enable additional rejuvenation cycles—potentially creating open-ended healthy lifespans for many alive today.Free sample chapter -Lies I Taught In Medical School : https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (20% off with 'LUFKIN20') https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (15% off) https://pathlongevity.com/Mimio Health (15% off with 'LUFKIN') https://mimiohealth.sjv.io/c/5810114/2745519/30611 *** CONNECT***Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmdBluesky: ...

Welcome back to the Abundance Hack Show, where we delve into the transformative power of alchemy, turning life's challenges into gold. In today's episode, our host Niajae explores the intricate dynamics of relationships, focusing on the concept of Female-Led Relationships (FLRs) and the often overlooked signs of emotional abuse. Following some intense feedback from the last episode with Cheri' Calico, Niajae addresses the misconceptions and societal programming that trigger heated reactions, particularly from men. She illuminates her perspective on why FLRs appeal to her, advocating for a shift away from traditional gender roles and encouraging emotional healing and growth on both sides of the relational spectrum. As an entrepreneur and creator, Niajae shares her journey towards embracing her full identity without shrinking for the comfort of traditionalism. Stick around as she offers insights into identifying emotionally abusive behavior and highlights the significance of mutual growth and emotional safety in cultivating Healthy Love. Whether you're familiar with the terms or not, this episode promises eye-opening discussions that invite us all to lean into the work of healing and transformation. The Healthy Love Healing App is your personal guide to deep healing, self-discovery, and empowerment.

In this episode, our host Niajae welcomes back the insightful Cheri' Calico. If you missed their enlightening discussion on Gene Keys and human design, you might want to check it out first for some foundational insights on Cheri'.  https://open.spotify.com/episode/272FXalT6yqzWhzgiEgZMv?si=WDdG0P2MSY-Hg26vCEmbKQ Now they are diving into something that's ever so pertinent, relationships and their various dynamics. Together, they peel back the layers of societal programming around what relationships should look like and introduce the concept of sacred unions. Cheri' elaborates on what healthy love means to her, rooted in the wholeness of individuals coming together. But that's not all. They take a close look at female-led relationships (FLRs), challenging the often narrow, traditional views of relationship roles. They discuss how these dynamics can defy outdated constructs of patriarchy and misogyny, empowering men and women to embrace their fullest selves. If you've ever questioned the roles we've been taught to play in relationships or want to explore how to create something more fulfilling and authentic, this episode promises to open new doors for you. Whether you're redefining what partnership means for you or curious about flipping the script on societal norms, Niajae and Cheri's dialogue is sure to inspire. Tune in for an insightful conversation that challenges the status quo and encourages profound personal and relational growth. Watch the episode on YouTube https://youtu.be/vVs0Ppspgjw Get in touch with Cheri' https://bit.ly/ConnectwithCheri https://www.instagram.com/chericalico Enroll in the Healthy Love Healing app https://healthylovehealing.com  

The STRANGE Disappearance of TARA CALICOBecome a supporter of this podcast: https://www.spreaker.com/podcast/missing-persons-mysteries--5624803/support.

In tonight's sleep story, Lance narrates, A Piece of Red Calico by Frank Stockton. Thank for being part of the Dozing Off community. Sleep well :)

This week your favorite co-op couple Luke Lewis and Claire Helmberger discuss their time playing Lost Records: Bloom & Rage, Afterlove EP, The Quilts and Cats of Calico and Avowed! Topics also include a news breakdown of the Last of Us Season 2 release date announcement! Thank you to Sandbox Strategies, Fellow Traveller and Monster Couch for providing us with review codes for this episode. New episodes of the LukeWarmGames Podcast launch every other week!Games Discussed During Today's Episode:Lost Records: Bloom & Rage - DON'T NOD Afterlove EP - Pikselnesia The Quilts and Cats of Calico - Monster CouchAvowed - Obsidian EntertainmentWe've Got The News Articles Discussed During Today's Episode:The Last of Us Season 2 Release Date Confirmed - Matt Kim, IGNFind us on Bluesky for show updates and more:Podcast: @lukewarmgames.bsky.socialLuke Lewis: @lukewarmlewis.bsky.socialClaire Helmberger: @clairebearrose.bsky.social

Vanished Without A Trace: The Tara Calico Disappearance!Become a supporter of this podcast: https://www.spreaker.com/podcast/missing-persons-mysteries--5624803/support.

  Andy Bowering, Chairman and interim-CEO at Apollo Silver (TSX.V:APGO - OTCQB:APGOF - FSE:6ZF0) joins us to introduce the Company, focused on the two asset, the Calico Project, in California and the Cinco de Mayo Project in Mexico.    At the Calico Silver Project, Andy walks us through its acquisition, historical resource, geological setting, and possible economic studies planned for this year. He highlights the significant silver and barite resources at Calico and the potential for gold discoveries. Additionally, Andy addresses concerns related to mining in California, emphasizing the project's mining-friendly location and existing infrastructure.    The discussion then shifts to the Cinco de Mayo project, a high-grade, historic carbonate replacement deposit (CRD) system. Andy dives deep into the complex history of the project, including previous ownership, substantial past drilling efforts, and the social challenges faced. However, Andy reveals recent positive developments: a new pro-development executive in the community and ongoing efforts to secure a social license. He explains Apollo's strategy to engage with the local community, develop partnerships, and navigate social challenges to unlock the project's full potential.   Click here to visit the Apollo Silver website.

Las acciones de Alphabet, la matriz de Google, cayeron el miércoles un 7% tras presentar unos ingresos que estaban por debajo de lo previsto en el cuarto trimestre. A pesar de ello, obtuvieron unos ingresos de más de 100.000 millones de dólares, un 36% más interanual. Su beneficio por acción fue de 2,15 dólares, dos centavos más de la previsión del mercado. También destacó su gran beneficio atribuido de 26.536 millones de dólares, un 28% más interanual. Debido a estas fortalezas, su CEO, Sundar Pichai, cree que ha sido un gran trimestre. Alphabet es un conglomerado que nació de una reestructuración corporativa de Google el 2 de octubre de 2015. En ella se alojan servicios como Fiber, Calico o Nest. Una de las grandes fortalezas de Google ha sido Google Cloud, su plataforma que ha reunido todas las aplicaciones de desarrollo web que Google estaba ofreciendo por separado. Anat Ashkenazi, Directora de finanzas de Alphabet. Es una de las causantes, eso sí, de la gran decepción de Alphabet en el mercado. La división cloud obtuvo 11.860 millones de dólares en ingresos, un volumen inferior a los 12.190 millones estimados por el mercado. Gemini es otra historia diferente. Gemini es el modelo de lenguaje de inteligencia artificial que presentó Google en mayo de 2023. Fue la gran apuesta de 2024 y este año no va a ser diferente. Alphabet anunció en su conferencia para inversores, que destinará 75.000 millones de dólares en gastos relacionados con la inteligencia artificial, de los que muchos acabarán siendo para Gemini. Así ve el futuro de la plataforma Pichai. Como otras grandes tecnológicas, como Facebook o META, Google ha tenido varias polémicas con algunos de sus servicios. Una de las grandes polémicas de los últimos años estuvo relacionada con su servicio Google Books. Fue en 2016, con el caso Authors Guild, la asociación de autores estadounidenses contra Google Books. En ella, los autores se quejaban que la digitalización de los libros por parte de la compañía, lo que suponía para ellos una vulneración contra los derechos de autor. La Corte Suprema de Estados Unidos acabó dando la razón a Google.

Calico Ghost Town, once a bustling mining community in California, now stands as a hauntingly empty relic of the past. There's the eerie history of this ghost town, where long-dead residents, including a mail-carrying dog, vengeful cowboys, and a grieving woman, continue to haunt the grounds. As you walk through the town, you might hear the sounds of forgotten music or feel the presence of spirits from its dark and tragic history. This is a tale of life, death, and the unwillingness to let go.You can find Edwin social media as @edwincovYou can get these ad-free through ScaryPlus.com free for 14 days, then 4.99 per month. Cancel anytime.Find out more about Horror Story on HorrorStory.comCheck out our other podcasts, like Scary Story Podcast on your favorite podcast app! Originally published in 2021 on our podcast, Dark Memory.

Calico Cats, Misheard Song Lyrics & Upset Sports FansSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

I do believe in StarClan! I do! I do!  Book: Warriors, Series 3: Power of Three #4: Eclipse Support us on Ko-fi! WCWITCast Ko-fi Follow us on BlueSky! WCWITCast Follow us on Instagram! WCWITCast  What We Are Reading (Not Sponsored): You & a Bike & a Road by Eleanor Davis The Elders' Quest - Warriors: Changing Skies #1 by Erin Hunter Cat Fact Sources: Willow the cat among awards finalists after saving the life of diabetic owner | UK News Cat saves owner's life by biting her boyfriend on the legs - Liverpool Echo Youtube - Cat saves diabetic owner's life Willow the cat who saved diabetic owner's life among finalists in National Cat Awards | The Independent National Cat Awards 2023: Meet the finalists! - BBC Newsround Deaf owner's hearing cat Zebby named National Cat of the Year 2023| Calico cat - Wikipedia Music: The following music was used for this media project: Happy Boy Theme by Kevin MacLeod  Link: https://incompetech.filmmusic.io/song/3855-happy-boy-themeLicense: http://creativecommons.org/licenses/by/4.0/

In this soul-stirring episode of The Abundance Hack Podcast, we dive deep into the profound wisdom of the Gene Keys with the incredible Cheri Calico, an expert in unlocking your higher potential through this transformational system.

This cat's major milestones all happened around Christmas!

In this episode, I reflect on stepping away from work to truly live. From an adventurous wheeling trip to Calico to ringing in New Year's Eve for the first time in years, I share how these moments have shaped my intentions for the new year. I'll also take you behind the lens at La Cruda Cruise, where getting out and creating—even with a slight hangover—felt like a refreshing start to 2025. I'll dive into my personal resolutions: being more present, prioritizing happiness, saying no to things that don't serve me, investing in meaningful relationships, and making time for passions like wrenching, cooking, and perfecting my craft. Plus, I'll share some advice inspired by serenity scripts to help you on your journey: embrace baby steps, harness the power of self-awareness, and remember that mindset changes begin with habit changes. Let's start this year by believing in ourselves and living intentionally. Stay Golden y'all

The Strange Disappearance of Tara CalicoBecome a supporter of this podcast: https://www.spreaker.com/podcast/missing-persons-mysteries--5624803/support.

Today, we have Emily Vincent, designer of the new game, Knitting Circle, a game in the wonderful cozy world of Calico. We talk to her about starting a party, and inviting wonderful guests that might make a difference! Or at least, try out this new Sauerkraut Sponge Cake we came up with. Thank you for listening!

In episode 130, we visit Calico Ghost Town in California. If you've ever made the drive from Los Angeles to Las Vegas, you might have passed right by this historic gem, tucked away just off Interstate 15 near Barstow. It's an iconic pit stop for road-trippers, and for good reason – Calico is an authentic Old West ghost town with a fascinating history and plenty to see. Episode Highlights In this episode, we discuss: The history of Calico, California Restoration of the town What to expect when visiting Calico Ghost Town The Places Where We Go Travel Resources The Places Where We Go Travel Resources TRAVEL BOOKS: While planning your travels, you can find links to several books to get you in the travel mindset on our Amazon Store Page - check out the section: Books That Inspire Travel  GEAR: Visit our Amazon Storefront for more travel resources - all we use personally. GET YOUR TRAVEL GEAR HERE! - The Places Where We Go Amazon Storefront Thanks for your support!   Inspiring Your Future Travels We hope this episode inspires you to consider visiting Wyoming.   The Places Where We Go PODCAST: Released every other week in your favorite podcast app WEBSITE & BLOG www.theplaceswherewego.com SUBSCRIBE TO OUR NEWSLETTER INSTAGRAM: https://www.instagram.com/theplaceswherewego TWITTER: https://twitter.com/theplaceswhere1 EMAIL: Write to us at comments@theplaceswherewego.com   We'll see you at the places where we go. Julie & Art   AFFILIATE LINK DISCLOSURE The Places Where We Go contains affiliate links and is a member of the Amazon Services LLC Associates Program. If you make a purchase using one of these Amazon links, we may receive compensation at no extra cost to you. Read our disclaimer and privacy policy for more information.

Vem chegando o final de ano, época de festas e natal. A demanda é alta para nossa lista de presentes. Para facilitar a sua vida e não precisar confiar em uma específica curadoria, o Fabuloso Podcast traz André Rumjanek compilando uma lista especial com Thais Petisquinho e Gabriel Googlebee, para ajudar você a escolher os melhores jogos para os melhores momento! Jogos mencionados neste episódio (mesmo que brevemente): Ticket to Ride, Azul, Marrakesh, King of Tokyo, Pandemic, Bang!, Bang! The Dice Game, Black Stories, Sintonia, Splendor, Jaipur, Schotten Totten, Trio, Uno, Exploding Kittens, Ark Nova, High Frontier 4 All, Projeto Gaia, Trickerion, Oath, Anachrony, Star Wars Rebellion, Destemidos: Normandia, Arkham Horror: The Card Game, Survive The Island, The Resistance, A Game of Throne, Everdell, Above And Below, Marvel Champions, Great Western Trail, Calico, Palm Island, Fate Flip, Paper Dungeons, Port Royal, Citadels, Secret Hitler, Coup, Heat: Pedal to the Metal, 7 Wonders, Insondável, Código Secreto, Entrelinhas, Harmonies, Detective, Chronicles of Crime Para saber mais sobre este episódio e os jogos mencionados: ⁠⁠⁠Jogos Para Todas As Ocasiões | Fabuloso Podcast⁠⁠⁠⁠ Se você ainda não conhece ou faz parte, fale conosco no nosso ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Fabuloso Discord⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ E para as redes sociais: ⁠⁠⁠⁠Fabuloso Podcast no ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠

Cats and Quilts..and iconic combo. In today's game we are going to discuss one of the more mechanically simple games we've played that also might be one of the thinkiest and crunchiest games we've discussed at the same time. In this Tile Laying Masterpiece you'll be assembling a quilt and attracting cats to cozy up on your beautifully masterpiece. How do the bards feel about it?? You'll have to watch to find out!!You can find Calico for yourself at:https://amzn.to/4g78GPoJason and Robbie have the goal of introducing non-gamers to the amazing world of tabletop gaming. With over 35 years of modern board gaming experience, we strive to open newer gamers to a variety of games that may be fun and exciting for them. Whether it's the theme, mechanics, or length of the game, we hope to demystify the negative stigma that often accompanies tabletop gaming and help players realize the tabletop gaming world is for everyone!We hope you accompany us on this journey … and join us at the table!Be sure to follow us on Instagram as well!https://www.instagram.com/bards_of_the_board/Chapters:0:00 Intro3:55 What We've Been Playing19:50 Calico55:15 Cookie Scale1:01:10 Final Thoughts

Welcome to the afterparty. We're gaming 'till we drop. Which might be pretty soon tbh because it turns out we're not as young as we once were. Alba articulates why we're still up gaming when all sensible souls have retired for the evening. Kenan's in charge of the quiz show this week which proves to be as bad an idea as it was last time. We explore the etymology of "meta" and Kenan recaps recent travels. Then we discuss games that keep us up when we're powering down, including Friday, Paleo, Hadrian's Wall, Lost Expedition, Eila and Something Shiny, Aqua, Cascadia, Meadow, Calico, Beacon Patrol, 8-bit difficulty, the Dylan of game design, modeling food chains, fast set-up, tactility, escalating challenges, and the limits of one's appetite for complexity. You tell us which games traipse across your tabletops in the wee hours, including Codenames Duet, The Seventh Citadel, Gloomhaven: Jaws of the Lion, Black Sonata, Akropolis, Nemesis: Lockdown, Next Station London, Unlock, Board Game Arena, and whatever Marvel Snap is. Finally, we congratulate ourselves for solving all the problems and challenge our listeners to be cool like us. Music by Alba and the Mighty Lions and Kenan. Sleep tight. Hosted on Acast. See acast.com/privacy for more information.

Land of the Lost: Tara CalicoBecome a supporter of this podcast: https://www.spreaker.com/podcast/missing-persons-mysteries--5624803/support.

Joining us this week is talented game composer Star Victoria Power, aka Slide20XX ⭐️ They've recently done work on games like Calico and Bloodstained: Dominique's Curse, and were even featured as part of Bandcamp's best soundtrack releases of 2022. Having worked towards making music for games since the age of 13, Star offers a lot of meaningful insight into how to balance pursuing your passions while still being practical. With music from Mistil! LINKS: ⭐️ Star's socials: @Slide20XX

It's time for the Comic Talk Headlines with Generally Nerdy! Netflix and Amazon implement new AI bitsNew horror movie trailersNew Joe Hill short storyAnd so much more...Plus, don't forget to subscribe for more fresh content. MusicFollow-ups/CorrectionsAs I Lay Dying - Tim Lambesis FINALLY responds. Acknowledges the environment has been toxic, and it trying to make that better for the next crew. Says that everyone leaving was due to Phil Sgrosso's decision to leave, which is odd considering his was the LAST announcement made. https://blabbermouth.net/news/tim-lambesis-admits-unhealthy-environment-within-as-i-lay-dying-led-to-split-with-his-bandmates Devildriver - Dez updates fans on positive health news. https://metalinjection.net/news/dez-fafara-gives-positive-health-update-promises-new-devildriver-coal-chamber New Music/VideoNeon Nightmare - They Look Like Shadows ttps://youtu.be/OyfYpMF8s_g?si=dDmFIwFE6vEScDvD More goth metal awesomeness… the video plays out like an 80s horror movie too. Faded Dream album out now. ALSO this video reveals the man behind the music. Nate Garrett from Spirit Adrift. Pre-Order the album!! https://www.20buckspin.com/collections/neon-nightmare Molotov Solution - Devour The Children https://youtu.be/HJxA5h0_L4Y politically charged deathcore. Very vocal heavy mix, but otherwise REALLY good. First new music since 2011. Title track from upcoming record.Extreme - Small Town Beautiful https://youtu.be/SIwU9T-SbdE trying to recapture that “More Than Words” spirit it seems. Not bad though.No Cure - Don't Need Your Help https://youtu.be/0tQ9RyLSAnw Bleeding Through labelmates. Featuring Jesse Clark of Wielded Steel and Nick Chance of Beautiful Child Of God. THAT is crushing!Paradise Slaves - A Fever to Defeat https://youtu.be/Tn_Iaj84phY featuring Joel Stroetzel's little brother Tyler, and 36 Crazyfists vocalist Brock Lindow. Kind of like a more melodic Crazyfists.Tours/FestivalsJudas Priest - 12-date trek will kick off on June 14, 2025 in Oslo, Norway and conclude on July 20, 2025 in Oberhausen, Germany.https://blabbermouth.net/news/judas-priest-announces-shield-of-pain-2025-european-tour Slipknot - EU Tour. June 4 in Sweden through June 28 in Spain for Resurrection Fest.https://blabbermouth.net/news/slipknot-announces-june-2025-european-tour Headbanger's Boat 2025 - LoG, Devildriver, Kublai Khan, Fear Factory, Obituary, Clutch MOREhttps://www.headbangersboat.com Reg ‘ol NewsQuincy Jones - Grammy winning producer passes at 91. The cause was not disclosed.https://variety.com/2024/film/news/quincy-jones-dead-grammy-winning-producer-1236199322/ KsE - New song “The Consequence” set for release Nov 20th.https://blabbermouth.net/news/killswitch-engage-announces-new-single-the-consequence Shadows Fall - Promise a new song in December.https://blabbermouth.net/news/shadows-fall-to-release-brand-new-song-next-month Slipknot - New logo… WTF?? Seems to ONLY be on certain limited merch.Limp Bizkit - Currently in the studio for a new record. John Otto LOST A TON OF WEIGHT!!SuggestsIron Never Lies - Now 6 episodes deep. This is a REALLY great podcast for fitness minded metalheads. Hosted by Brandon Schiepetti from Bleeding Through.Gaming/TechFollow-ups/CorrectionsNetflix - After closing their AAA game studio, they now are opening an AI game studio… nice…?Reg ‘ol NewsAmazon Prime - Amazon will now include AI generated recaps and summaries for shows. But they SWEAR they will be spoiler free.https://variety.com/2024/tv/news/prime-video-x-ray-artificial-intelligence-tv-show-recaps-1236199827/ Hogwarts Legacy 2 - Officially in the works, and will tie into the reboot tv show, creating a connected universe.https://comicbook.com/gaming/news/hogwarts-legacy-2-harry-potter-tv-show/ Mass Effect - Dragon Ages: Veilgard is not getting DLC, because BioWare is turning focus to Mass Effect 5.SuggestsDUHComic Books/BooksReg ‘ol NewsCalico - Mike Baron's new book. Book 2 is a 48 page double issue also featuring writer HH German. Kickstarter goes live Nov 12.https://www.kickstarter.com/projects/sigmacomics/here-comes-calico-prologue-for-book-2 Sherlock Holmes: Leviathan - ANOTHER new book from Mike Baron with art from Richard Bonk. Crowdfund campaign runs through Jan 3. https://www.indiegogo.com/projects/sherlock-holmes-leviathan Ushers - New Joe Hill book. Short story.https://www.goodreads.com/book/show/218362004-ushers SuggestsPenguin: Pain and Prejudice. 2011 by Gregg HurwitzTV ShowsFollow-ups/CorrectionsGen V - season 2 has finished principal photography. To be released in 2025. https://comicbook.com/tv-shows/news/gen-v-stars-confirm-major-update-about-season-2-of-the-boys-spinoff-series/ Lanterns - Garret Dillahunt has joined the cast of the Max series. https://thathashtagshow.com/2024/11/01/garret-dillahunt-lanterns-recurring-role/ TrailersStar Wars: Skeleton Crew - https://youtu.be/f19gfOMZTtg meh… though that's better than GAH! Still looks like fun though. The song choice is interesting… why go with something from the 80s like that? Even if it IS in Huttese. Begins Dec 3.Mayfair Witches - https://youtu.be/3MNwkfKwNwY season 2 Jan 5 2025 on AMC.The Walking Dead: Daryl Dixon - https://youtu.be/p1DH9-prniI season 3. Daryl and Carol in SPAIN.Landman - https://youtu.be/wXzhEhCOlnM New Taylor Sheridan series in Texas with Billy Bob Thornton, Demi Moore, and John Hamm. Paramount+ Nov 17.SuggestsPenguin - Just keeps giving!MoviesFollow-ups/CorrectionsPinocchio: Unstrung - Started casting with Robert Englund and Richard Brake. Brake will be Geppetto, while Englund's role has not been revealed. https://comicbook.com/horror/news/pinocchio-slasher-movie-recruits-horror-icons-robert-englund-richard-brake/ Twilight of the Dead - The George A Ramero zombie movie that is supposed to be the conclusion to the filmmaker's oeuvre is FINALLY casting after 7 years in the making, and after it's creator's passing. Mila Jovovich and Betty Gabriel have both been cast for the film, to work with Brad Anderson (Session 9) as director. Suzanne Romero has been working with screen writers Joe Knetter, Robert L Lucas, and Paolo Zelati, who were working with Gorge previous to his passing. https://deadline.com/2024/11/milla-jovovich-betty-gabriel-george-a-romero-zombie-movie-twilight-of-the-dead-1236164891/ TrailersDo Not Open - https://youtu.be/947I6zKNVfI New horror movie about the dangers of tech… not original, but looks interesting.Heart Eyes - https://youtu.be/P6rkV4NVrOg new Valentine's Day horror movie from the Freaky and Happy Death Day studio. Feb 7 2025. Looks SUPER gory…Presence - https://youtu.be/XfSNmYhV8Xc New Steven Soderbbergh horror movie. Jan 24 2025Reg ‘ol NewsLego: Ninjago - Live-action movie in the works? Kevin and Dan Hageman, who are responsible for the Ninjago animated series, are working on a new movie for Universal. To be part of a larger live-action slate of Lego movies all in development at Universal.https://deadline.com/2024/10/lego-ninjago-movie-kevin-hageman-dan-hageman-in-works-universal-1236163709/ Gundam - Live-action movie in the works. Jim Mickle chosen to write and direct by Legendary and Bandai Namco Filmworks.https://deadline.com/2024/10/gundam-movie-sweet-tooth-jim-mickle-1236163584/ House of the Dead - NEW movie in the works. THIS time from Paul WS Anderson. The MK ‘95 director (Resident Evil, Monster Hunter) will also co-write.https://deadline.com/2024/10/house-of-the-dead-movie-paul-w-s-anderson-sega-game-1236163599/ Orphan - A third movie in the franchise has been announced. Star Isabelle Fuhrman is set to return as the titular “orphan.” The writer and director from the second movie, Orphan: First Kill, David Coggeshall and William Brent Bell, will also be returning.https://variety.com/2024/film/global/orphan-3-official-lionsgate-isabelle-fuhrman-1236199428/ The Substance - Finally available to stream. Only it's on Mubi… who has Mubi? You can sign up for a 7-day free trial through Amazon Prime, or just purchase the movie on Prime directly.https://variety.com/2024/film/news/how-to-watch-the-substance-online-streaming-1236199912/#article-comments Godzilla - New Toho movie in the works from the director that gave us Godzilla Minus One, Takashi Yamazaki. Will be the 38th Godzilla movie.https://www.hollywoodreporter.com/movies/movie-news/new-godzilla-movie-takashi-yamazaki-1236051588/ Cliffhanger - Reboot in the works. Sylvester Stallone was originally attached to star, has left the project. Starring Lily James and Pierce Brosnan (replacing Stallone). Original movie was out in 1993.https://www.hollywoodreporter.com/movies/movie-news/cliffhanger-reboot-lily-james-pierce-brosnan-1236050367/ Emily the Strange - Feature length animated movie in the works from WB and Bad Robot.https://www.hollywoodreporter.com/movies/movie-news/emily-the-strange-animated-movie-warner-bros-1236049005/ SuggestsAddams Family Valuesa 1993 American supernatural black comedy film directed by Barry Sonnenfeld and written by Paul Rudnick, based on the characters created by Charles Addams. It is the sequel to The Addams Family (1991). The film features almost all the main cast members from the original filmRumor MillConfirmations/RefutationsCONFIRM: Agatha All Along - Aubrey Plaza's character IS Lady Death. And no one cares…New RumorsAgent Venom - Said to be in the works ALREADY! Flash Thompson the new host. Also said to be set for release PRE-Secret Wars, with ties to the Scarlet Witch, AND the Sinister Six that has been on the back burner forEVER.Game of Thrones - MOVIE in the works according to the trades. Said to be an extension of the HBO series. Weiss and Bennioff wanted to end the series originally with a 3-part movie…Wolverine - New game from Insomniac likely pushed back, as it is said that they have decided to “go in a new direction,” and are replacing the creative director and the game director on the project, Brian Horton. Now the Ratchet and Clank directors are in charge. Days of Thunder - Tom Cruise is apparently just trying to stay as busy as possible. This on top of Mission: Impossible Dead Reckoning, and the Top Gun: Maverick sequel?Fantastic Four - Sub-title changed to First Contact from First Steps.Death/Wiccan - Both characters are rumored to see a series based on one or both of them. Pilots for both?Agatha - Season 2???Blade - Eyeing the November 2026 release date on the Marvel release slate.You can support this show by visiting our merch store, or by leaving us an Apple Podcasts review.

It's time for the Comic Talk Headlines with Generally Nerdy! Netflix and Amazon implement new AI bitsNew horror movie trailersNew Joe Hill short storyAnd so much more...Plus, don't forget to subscribe for more fresh content. MusicFollow-ups/CorrectionsAs I Lay Dying - Tim Lambesis FINALLY responds. Acknowledges the environment has been toxic, and it trying to make that better for the next crew. Says that everyone leaving was due to Phil Sgrosso's decision to leave, which is odd considering his was the LAST announcement made. https://blabbermouth.net/news/tim-lambesis-admits-unhealthy-environment-within-as-i-lay-dying-led-to-split-with-his-bandmates Devildriver - Dez updates fans on positive health news. https://metalinjection.net/news/dez-fafara-gives-positive-health-update-promises-new-devildriver-coal-chamber New Music/VideoNeon Nightmare - They Look Like Shadows ttps://youtu.be/OyfYpMF8s_g?si=dDmFIwFE6vEScDvD More goth metal awesomeness… the video plays out like an 80s horror movie too. Faded Dream album out now. ALSO this video reveals the man behind the music. Nate Garrett from Spirit Adrift. Pre-Order the album!! https://www.20buckspin.com/collections/neon-nightmare Molotov Solution - Devour The Children https://youtu.be/HJxA5h0_L4Y politically charged deathcore. Very vocal heavy mix, but otherwise REALLY good. First new music since 2011. Title track from upcoming record.Extreme - Small Town Beautiful https://youtu.be/SIwU9T-SbdE trying to recapture that “More Than Words” spirit it seems. Not bad though.No Cure - Don't Need Your Help https://youtu.be/0tQ9RyLSAnw Bleeding Through labelmates. Featuring Jesse Clark of Wielded Steel and Nick Chance of Beautiful Child Of God. THAT is crushing!Paradise Slaves - A Fever to Defeat https://youtu.be/Tn_Iaj84phY featuring Joel Stroetzel's little brother Tyler, and 36 Crazyfists vocalist Brock Lindow. Kind of like a more melodic Crazyfists.Tours/FestivalsJudas Priest - 12-date trek will kick off on June 14, 2025 in Oslo, Norway and conclude on July 20, 2025 in Oberhausen, Germany.https://blabbermouth.net/news/judas-priest-announces-shield-of-pain-2025-european-tour Slipknot - EU Tour. June 4 in Sweden through June 28 in Spain for Resurrection Fest.https://blabbermouth.net/news/slipknot-announces-june-2025-european-tour Headbanger's Boat 2025 - LoG, Devildriver, Kublai Khan, Fear Factory, Obituary, Clutch MOREhttps://www.headbangersboat.com Reg ‘ol NewsQuincy Jones - Grammy winning producer passes at 91. The cause was not disclosed.https://variety.com/2024/film/news/quincy-jones-dead-grammy-winning-producer-1236199322/ KsE - New song “The Consequence” set for release Nov 20th.https://blabbermouth.net/news/killswitch-engage-announces-new-single-the-consequence Shadows Fall - Promise a new song in December.https://blabbermouth.net/news/shadows-fall-to-release-brand-new-song-next-month Slipknot - New logo… WTF?? Seems to ONLY be on certain limited merch.Limp Bizkit - Currently in the studio for a new record. John Otto LOST A TON OF WEIGHT!!SuggestsIron Never Lies - Now 6 episodes deep. This is a REALLY great podcast for fitness minded metalheads. Hosted by Brandon Schiepetti from Bleeding Through.Gaming/TechFollow-ups/CorrectionsNetflix - After closing their AAA game studio, they now are opening an AI game studio… nice…?Reg ‘ol NewsAmazon Prime - Amazon will now include AI generated recaps and summaries for shows. But they SWEAR they will be spoiler free.https://variety.com/2024/tv/news/prime-video-x-ray-artificial-intelligence-tv-show-recaps-1236199827/ Hogwarts Legacy 2 - Officially in the works, and will tie into the reboot tv show, creating a connected universe.https://comicbook.com/gaming/news/hogwarts-legacy-2-harry-potter-tv-show/ Mass Effect - Dragon Ages: Veilgard is not getting DLC, because BioWare is turning focus to Mass Effect 5.SuggestsDUHComic Books/BooksReg ‘ol NewsCalico - Mike Baron's new book. Book 2 is a 48 page double issue also featuring writer HH German. Kickstarter goes live Nov 12.https://www.kickstarter.com/projects/sigmacomics/here-comes-calico-prologue-for-book-2 Sherlock Holmes: Leviathan - ANOTHER new book from Mike Baron with art from Richard Bonk. Crowdfund campaign runs through Jan 3. https://www.indiegogo.com/projects/sherlock-holmes-leviathan Ushers - New Joe Hill book. Short story.https://www.goodreads.com/book/show/218362004-ushers SuggestsPenguin: Pain and Prejudice. 2011 by Gregg HurwitzTV ShowsFollow-ups/CorrectionsGen V - season 2 has finished principal photography. To be released in 2025. https://comicbook.com/tv-shows/news/gen-v-stars-confirm-major-update-about-season-2-of-the-boys-spinoff-series/ Lanterns - Garret Dillahunt has joined the cast of the Max series. https://thathashtagshow.com/2024/11/01/garret-dillahunt-lanterns-recurring-role/ TrailersStar Wars: Skeleton Crew - https://youtu.be/f19gfOMZTtg meh… though that's better than GAH! Still looks like fun though. The song choice is interesting… why go with something from the 80s like that? Even if it IS in Huttese. Begins Dec 3.Mayfair Witches - https://youtu.be/3MNwkfKwNwY season 2 Jan 5 2025 on AMC.The Walking Dead: Daryl Dixon - https://youtu.be/p1DH9-prniI season 3. Daryl and Carol in SPAIN.Landman - https://youtu.be/wXzhEhCOlnM New Taylor Sheridan series in Texas with Billy Bob Thornton, Demi Moore, and John Hamm. Paramount+ Nov 17.SuggestsPenguin - Just keeps giving!MoviesFollow-ups/CorrectionsPinocchio: Unstrung - Started casting with Robert Englund and Richard Brake. Brake will be Geppetto, while Englund's role has not been revealed. https://comicbook.com/horror/news/pinocchio-slasher-movie-recruits-horror-icons-robert-englund-richard-brake/ Twilight of the Dead - The George A Ramero zombie movie that is supposed to be the conclusion to the filmmaker's oeuvre is FINALLY casting after 7 years in the making, and after it's creator's passing. Mila Jovovich and Betty Gabriel have both been cast for the film, to work with Brad Anderson (Session 9) as director. Suzanne Romero has been working with screen writers Joe Knetter, Robert L Lucas, and Paolo Zelati, who were working with Gorge previous to his passing. https://deadline.com/2024/11/milla-jovovich-betty-gabriel-george-a-romero-zombie-movie-twilight-of-the-dead-1236164891/ TrailersDo Not Open - https://youtu.be/947I6zKNVfI New horror movie about the dangers of tech… not original, but looks interesting.Heart Eyes - https://youtu.be/P6rkV4NVrOg new Valentine's Day horror movie from the Freaky and Happy Death Day studio. Feb 7 2025. Looks SUPER gory…Presence - https://youtu.be/XfSNmYhV8Xc New Steven Soderbbergh horror movie. Jan 24 2025Reg ‘ol NewsLego: Ninjago - Live-action movie in the works? Kevin and Dan Hageman, who are responsible for the Ninjago animated series, are working on a new movie for Universal. To be part of a larger live-action slate of Lego movies all in development at Universal.https://deadline.com/2024/10/lego-ninjago-movie-kevin-hageman-dan-hageman-in-works-universal-1236163709/ Gundam - Live-action movie in the works. Jim Mickle chosen to write and direct by Legendary and Bandai Namco Filmworks.https://deadline.com/2024/10/gundam-movie-sweet-tooth-jim-mickle-1236163584/ House of the Dead - NEW movie in the works. THIS time from Paul WS Anderson. The MK ‘95 director (Resident Evil, Monster Hunter) will also co-write.https://deadline.com/2024/10/house-of-the-dead-movie-paul-w-s-anderson-sega-game-1236163599/ Orphan - A third movie in the franchise has been announced. Star Isabelle Fuhrman is set to return as the titular “orphan.” The writer and director from the second movie, Orphan: First Kill, David Coggeshall and William Brent Bell, will also be returning.https://variety.com/2024/film/global/orphan-3-official-lionsgate-isabelle-fuhrman-1236199428/ The Substance - Finally available to stream. Only it's on Mubi… who has Mubi? You can sign up for a 7-day free trial through Amazon Prime, or just purchase the movie on Prime directly.https://variety.com/2024/film/news/how-to-watch-the-substance-online-streaming-1236199912/#article-comments Godzilla - New Toho movie in the works from the director that gave us Godzilla Minus One, Takashi Yamazaki. Will be the 38th Godzilla movie.https://www.hollywoodreporter.com/movies/movie-news/new-godzilla-movie-takashi-yamazaki-1236051588/ Cliffhanger - Reboot in the works. Sylvester Stallone was originally attached to star, has left the project. Starring Lily James and Pierce Brosnan (replacing Stallone). Original movie was out in 1993.https://www.hollywoodreporter.com/movies/movie-news/cliffhanger-reboot-lily-james-pierce-brosnan-1236050367/ Emily the Strange - Feature length animated movie in the works from WB and Bad Robot.https://www.hollywoodreporter.com/movies/movie-news/emily-the-strange-animated-movie-warner-bros-1236049005/ SuggestsAddams Family Valuesa 1993 American supernatural black comedy film directed by Barry Sonnenfeld and written by Paul Rudnick, based on the characters created by Charles Addams. It is the sequel to The Addams Family (1991). The film features almost all the main cast members from the original filmRumor MillConfirmations/RefutationsCONFIRM: Agatha All Along - Aubrey Plaza's character IS Lady Death. And no one cares…New RumorsAgent Venom - Said to be in the works ALREADY! Flash Thompson the new host. Also said to be set for release PRE-Secret Wars, with ties to the Scarlet Witch, AND the Sinister Six that has been on the back burner forEVER.Game of Thrones - MOVIE in the works according to the trades. Said to be an extension of the HBO series. Weiss and Bennioff wanted to end the series originally with a 3-part movie…Wolverine - New game from Insomniac likely pushed back, as it is said that they have decided to “go in a new direction,” and are replacing the creative director and the game director on the project, Brian Horton. Now the Ratchet and Clank directors are in charge. Days of Thunder - Tom Cruise is apparently just trying to stay as busy as possible. This on top of Mission: Impossible Dead Reckoning, and the Top Gun: Maverick sequel?Fantastic Four - Sub-title changed to First Contact from First Steps.Death/Wiccan - Both characters are rumored to see a series based on one or both of them. Pilots for both?Agatha - Season 2???Blade - Eyeing the November 2026 release date on the Marvel release slate.You can support this show by visiting our merch store, or by leaving us an Apple Podcasts review.

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Rocco hops in the studio as we discuss the Top 5 Music Biopics of all time. Brittany and Mike are over Taylor... wait what?!!? We also play the Over/Under game and what is with this Calico hair TikTok Trend Learn more about your ad choices. Visit podcastchoices.com/adchoices

When I think of digital biology, I think of Patrick Hsu—he's the prototype, a rarified talent in both life and computer science, who recently led the team that discovered bridge RNAs, what may be considered CRISPR 3.0 for genome editing, and is building new generative A.I. models for life science. You might call them LLLMs-large language of life models. He is Co-Founder and a Core Investigator of the Arc Institute and Assistant Professor of Bioengineering and Deb Faculty Fellow at the University of California, Berkeley.Above is a brief snippet of our conversation. Full videos of all Ground Truths podcasts can be seen on YouTube here. The audios are also available on Apple and Spotify.Here's the transcript with links to the audio and external links to relevant papers and things we discussed.Eric Topol (00:06):Well hello, it's Eric Topol with Ground Truths and I'm really delighted to have with me today Patrick Hsu. Patrick is a co-founder and core investigator at the Arc Institute and he is also on the faculty at the University of California Berkeley. And he has been lighting things up in the world of genome editing and AI and we have a lot to talk about. So welcome, Patrick.Patrick Hsu (00:29):Thanks so much. I'm looking forward to it. Appreciate you having me on, Eric.The Arc InstituteEric Topol (00:33):Well, the first thing I'd like to get into, because you're into so many important things, but one that stands out of course is this Arc Institute with Patrick Collison who I guess if you can tell us a bit about how you two young guys got to meet and developed something that's really quite unique that I think brings together investigators at Stanford, UCSF, and Berkeley. Is that right? So maybe you can give us the skinny about you and Patrick and how all this got going.Patrick Hsu (01:05):Yeah, sure. That sounds great. So we started Arc with Patrick C and with Silvana Konermann, a longtime colleague and chemistry faculty at Stanford about three years ago now, though we've been physically operational just over two years and we're an independent research institute working at the interface of biomedical science and machine learning. And we have a few different aspects of our model, but our overall mission is to understand and treat complex human diseases. And we have three pillars to our model. We have this PI driven side of the house where we centrally fund our investigators so that they don't have to write grants and work on their very best ideas. We have a technical staff side of the house more like you'd see in a frontier AI lab or in biotech industry where we have professional teams of R&D scientists working cross-functionally on higher level organizational wide goals that we call our institute initiatives.(02:05):One focused on Alzheimer's disease experimentally and one that we call a virtual cell initiative to simulate human biology with AI foundation models. And our third pillar over time is to have things not just end up as academic papers, but really get things out into the real world as products or as medicines that can actually help patients on the translational side. And so, we thought that some really important scientific programs could be unlocked by enabling new organizational models and we are experimenting at the institutional scale with how we can better organize and incentivize and support scientists to reach these long-term capability breakthroughs.Patrick, Patrick and SilvanaEric Topol (02:52):So the two Patrick's. How did you, one Patrick I guess is a multi-billionaire from Stripe and then there's you who I suspect maybe not quite as wealthy as the other Patrick, how did you guys come together to do this extraordinary thing?Patrick Hsu (03:08):Yeah, no, science is certainly expensive. I met Patrick originally through Silvana actually. They actually met, so funny trivia, all three Arc founders did high school science together. Patrick and Silvana originally met in the European version of the European Young Scientist competition in high school. And Silvana and I met during our PhDs in her case at MIT and I was at Harvard, but we met at the Broad Institute sort of also a collaborative Harvard, MIT and Harvard hospitals Institute based in Kendall Square. And so, we sort of in various pairwise combinations known each other for decades and worked together for decades and have all collectively been really excited about science and technology and its potential to accelerate societal progress. Yet we also felt in our own ways that despite a lot of the tremendous progress, the structures in which we do this work, fund it, incentivize it and roll it out into the real world, seems like it's really possible that we'll undershoot that potential. And if you take 15 years ago, we didn't have the modern transformer that launched the current AI revolution, CRISPR technology, single-cell, mRNA technology or broadly addressable LNPs. That's a tremendous amount of technologies have developed in the next 15 years. We think there's a real unique opportunity for new institutes in the 2020s to take advantage of all of these breakthroughs and the new ones that are coming to continue to accelerate biological progress but do so in a way that's fast and flexible and really focused.Eric Topol (04:58):Yeah, I did want to talk with you a bit. First of all before I get to the next related topic, I get a kick out of you saying you've worked or known each other for decades because I think you're only in your early thirties. Is that right?Patrick Hsu (05:14):I was lucky to get an early start. I first started doing research at the local university when I was 14 actually, and I was homeschooled actually until college. And so, one of the funny things that you got to do when you're homeschooled is well, you could do whatever you want. And in my case that was work in the lab. And so, I actually worked basically full time as an intern volunteer, cut my teeth in single cell patch clamp, molecular biology, protein biochemistry, two photon and focal imaging and kind of spiraled from there. I loved the lab, I loved doing bench work. It was much more exciting to me than programming computers, which was what I was doing at the time. And I think these sort of two loves have kind of brought me and us to where we are today.Eric Topol (06:07):Before you got to Berkeley and Arc, I know you were at Broad Institute, but did you also pick up formal training in computer science and AI or is that something that was just part of the flow?Patrick Hsu (06:24):So I grew up coding. I used to work through problems sets before dinner growing up. And so, it's just something that you kind of learn natively just like learning French or Mandarin.New Models of Funding Life ScienceEric Topol (06:42):That's what I figured. Okay. Now this model of Arc Institute came along in a kind of similar timeframe as the Arena BioWorks in Boston, where some of the faculty left to go to Arena like my friend Stuart Schreiber and many others. And then of course Priscilla and Mark formed the Chan Zuckerberg Institute and its biohub and its support. So can you contrast for one, these three different models because they're both very different than of course the traditional NIH pathway, how Arc is similar or different to the others, and obviously the goal here is accelerating things that are going to really make a difference.Patrick Hsu (07:26):Yeah, the first thing I would say is zooming out. There have been lots of efforts to experiment with how we do science, the practice of science itself. And in fact, I've recently been reading this book, the Demon Under the Microscope about the history of infectious disease, and it talks about how in the 1910s through the 1930s, these German industrial dye manufacturing companies like Bayer and BASF actually launched what became essentially an early model for industrial scale science, where they were trying to develop Prontosil, Salvarsan and some of these early anti-infectives that targeted streptococcus. And these were some of the major breakthroughs that led to huge medical advances on tackling infectious disease compared to the more academic university bound model. So these trends of industrial versus academic labs and different structures to optimize breakthroughs and applications has been a through current throughout international science for the last century.(08:38):And so, the way that we do research today, and that's some of our core tenets at Arc is basically it hasn't always been this way. It doesn't need to necessarily be this way. And so, I think organizational experiments should really matter. And so, there's CZI, Altos, Arena, Calico, a variety of other organizational experiments and similarly we had MRC and Bell Labs and Xerox PARCS, NIBRT, GNF, Google Research, and so on. And so, I think there are lots of different ways that you can organize folks. I think at a high level you can think about ways that you can play with for-profit versus nonprofit structures. Whether you want to be a completely independent organization or if you want to be partnered with universities. If you want to be doing application driven science or really blue sky curiosity driven work. And I think also thinking through internally the types of expertise that you bring together.(09:42):You can think of it like a cancer institute maybe as a very vertically integrated model. You have folks working on all kinds of different areas surrounding oncology or immunotherapy and you might call that the Tower of Babel model. The other way that folks have built institutes, you might call the lily pad model where you have coverage of as many areas of biomedical research as possible. Places like the Whitehead or Salk, it will be very broad. You'll have planned epigenetics, folks looking at RNA structural biology, people studying yeast cell cycle, folks doing in vivo melanoma models. It's very broad and I think what we try to do at Arc is think about a model that you might liken more to overlapping Viking shields where there's sort of five core areas that we're deeply investing in, in genetics and genomics, computation, neuroscience, immunology and chemical biology. Now we really think of these as five areas that are maybe the minimal critical mass that you would need to make a dent on something as complicated as complex human diseases. It's certainly not the only thing that you need, but we needed a critical mass of investigators working at least in these areas.Eric Topol (11:05):Well, yeah, and they really converge on where the hottest advances are being made these days. Now can you work at Arc Institute without being one of these three universities or is it really that you maintain your faculty and your part of this other entity?Patrick Hsu (11:24):So we have a few elements to even just the academic side of the house. We have our core investigators. I'm one of them, where we have dually appointed faculty who retain their latter rank or tenured appointment in their home department, but their labs are physically cited at the Arc headquarters where we built out a lab in Stanford Research Park in Palo Alto. And so, folks move their labs there. They continue to train graduate students based on whatever graduate programs they're formally affiliated with through their university affiliation. And so, we have nearly 40 PhD students across our labs that are training on site every day.(12:03):So in addition to our core investigators, we also have what we call our innovation investigators, which is more of a grant program to faculty at our partner universities. They receive unrestricted funding from us to seed a new project or accelerate an existing area in their group and their labs stay at their home campus and they just get that funding to augment their work. The third way is our technical staff model where folks basically just come work at Arc and many of them also are establishing their own research groups focusing on technology R&D areas. And so, we have five of those technology centers working in molecular engineering, multi-omics, complex cellular models, in vivo models, and in machine learning.Discovery of Bridge RNAsEric Topol (12:54):Yeah, that's a great structure. In fact, just a few months ago, Patrick Collison, the other Patrick came to Stanford HAI where I'm on the board and you've summarized it really well and it's very different than the other models and other entities, companies included that you mentioned. It's really very impressive. Now speaking of impressive on June 26, this past few months ago, which incidentally is coincident with the draft genome in the year 2000, the human sequence. You and your colleagues, perhaps the most impressive jump in terms of an Arc Institute contribution published two papers back-to-back in Nature about bridge RNA: [Bridge RNAs direct programmable recombination of target and donor DNA] and [Structural mechanism of bridge RNA-guided recombination.] And before I get you to describe this breakthrough in genome editing, some would call it genome editing 3.0 or CRISPR 3.0, whatever. But what we have today in the clinic with the approval of CRISPR 1.0 for sickle cell and thalassemia is actually quite crude. I think most people will know it's just a double stranded DNA cleavage with all sorts of issues about repair and it's not very precise. And so, CRISPR 2.0 is supposed to be represented by David Liu's contributions and his efforts at Broad like prime and base editing and then comes yours. So maybe you can tell us about it and how it is has to be viewed as quite an important advance.Patrick Hsu (14:39):The first thing I would say before CRISPR, is that we had RNA interference. And so, even before this modern genome editing revolution with programmable CRISPRs, we had this technology that had a lot of the core selling points as well. Any target will now become druggable to us. We simply need to reprogram a guide RNA and we can get genetic access to things that are intracellular. And I think both the discovery of RNA interference by Craig Mello and Andy Fire or the invention or discovery of programmable CRISPR technologies, both depend on the same fundamental biological mechanism. These non-coding guide RNAs that are essentially a short RNA search string that you can easily reprogram to retarget a desired enzyme function, and natively both RNAi and CRISPR are molecular scissors. Their RNA or DNA nucleases that can be reprogrammed to different regions of the genome or the transcriptome to make a cut.(15:48):And as bioengineers, we have come up with all kinds of creative ways to leverage the ability to make site specific cuts to do all kinds of incredible things including genome editing or beyond transcriptional up or down regulation, molecular imaging and so on and so forth. And so, the first thing that we started thinking about in our lab was, why would mother nature have stopped only RNAi and CRISPR? There probably are lots of other non-coding RNAs out there that might be able to be programmable and if they did exist, they probably also do more complicated and interesting things than just guide a molecular scissors. So that was sort of the first core kind of intuition that we had. The second intuition that we had on the technology side, I was just wearing my biology hat, I'll put on my technology hat, is the thing that we call genome editing today hardly involves the genome.(16:50):It's really you're making a cut to change an individual base or an individual gene or locus. So really you're doing small scale single locus editing, so you might call it gene level or locus level cuts. And what you really want to be able to do is do things at the genome scale at 100 kb, a megabase at the chromosome scale. And I think that's where I think the field will inevitably go if you follow the technology curves of longer and longer range gene sequencing, longer and longer range gene synthesis, and then longer and longer range gene editing. And so, what would that look like? And we started thinking, could there be essentially recombination technologies that allow you to do cut and paste in a single step. Now, the reason for that is the way that we do gene editing today involves a cut and then a multi-step process of cellular DNA repair that resolves the cut to make the exertion or the error prone deletion or the modification that ends up happening.(17:59):And so, it's very complicated and whether that's nucleases or base or prime editing, you're all generally limited to the small-scale single locus changes. However, there are natural mechanisms that have solved this cut and paste problem, right? There are these viruses or bacterial versions of viruses known as phage that have generally been trying to exert their multi kilobase genomes into bacterial hosts and specialize throughout billions of years. So our core thought was, well, if there are these new non-coding RNAs, what kind of functions would we be excited about? Can we look in these mobile genetic elements, these so-called jumping genes for new mechanisms? They're incredibly widespread. Transposons are thought to be some of the most diverse enzyme mechanisms found in nature. And so, we started computationally by asking ourselves a very simple question. If a mobile element inserts itself into foreign DNA and it's able to somehow be programmable, presumably the inside or something encoded in the inside of the element is predictive of some sequence on the outside of the element.(19:15):And so, that was the core insight we took, and we thought let's look across the boundaries of many different mobile genetic elements and we zoomed in on a particular sub family of these MGE known as insertion sequence (IS) elements which are the most autonomous minimal transposons. Normally transposons have all kinds of genes that they use to hitchhike around the genomic galaxy and endow the bacterial host with some fitness advantage like some ability to metabolize some copper and some host or some metal. And these IS elements have only the enzymes that they need to jump around. And if you identify the boundaries of these using modern computational methods, this is actually a really non-trivial problem. But if you solve that problem to figure out with nucleotide resolution where the element boundaries end and then you look for the open reading frame of the transposases enzyme inside of this element, you'll find that it's not just that coding sequence.(20:19):There are also these non-coding flanks inside of the element boundaries. And when we looked across the non-coding, the entire IS family tree, there are hundreds of these different types of elements. We found that this particular family IS110, had the longest non-coding ends of all IS elements. And we started doing experiments in the lab to try to figure out how these work. And what we found was that these elements are cut and paste elements, so they excise themselves into a circular form and paste themselves back in into a target site linearly. But the circularization of this element brings together two distal ends together, which brings together a -35 and a -10 box that create and reconstitute a canonical bacterial transcriptional promoter. This essentially is like plugging a plug into an electrical socket in the wall and it jacks up transcription. Now you would think this transcription would turn on the transposase enzyme so it can jump around more but it transcribes a non-coding RNA out of this non-coding end.(21:30):We're like, holy crap, are these RNAs actually involved in regulating the transposon? Now the boring answer would be, oh, it regulates the expression. It's like an antisense regulate or something. The exciting answer would be, oh, it's a new type of guide RNA and you found an RNA guided integrase. So we started zooming in bound dramatically on this and we undertook a covariation analysis where we were able to show that this cryptic non-coding RNA has a totally novel guide RNA structure, totally distinct from RNAi or CRISPR guide RNAs. And it had a target site that covaried with the target site of the element. And so we're like, oh wow, this could be a programmable transposase. The second thing that we found was even more surprising, there was a second region of complementarity in that same RNA that recognized the donor sequence, which is the circularized element itself. And so, this was the first example of a bispecific guide RNA, and also the first example of RNA guided self-recognition by a mobile genetic element.Eric Topol (22:39):It's pretty extraordinary because basically you did a systematic assessment of jumping genes or transposons and you found that they contain things that previously were not at all recognized. And then you have a way to program these to edit, change the genome without having to do any cuts or nicks, right?Patrick Hsu (23:05):Yeah. So what we showed in a test tube is when we took this, so-called bridge RNA, which we named because it bridges the target and donor together along with the recombinase enzyme. So the two component system, those are the only two things that you need. They're able to cut and paste DNA and recombine them in a test tube without any DNA repair, meaning that it's independent of cellular DNA repair and it does strand nicking, exchange, junction resolution and religation all in a single mechanism. So that's when we got super excited about its potential applications as bioengineering tool.Eric Topol (23:46):Yeah, it's pretty extraordinary. And have you already gone into in vivo assessment?Patrick Hsu (23:54):Yes, in our initial set of papers, what we showed is that these are programmable and functional or recombinases in a test tube and in bacterial cells. And by reprogramming the target and donor the right way, you can use these enzymes not just for insertion, but also for flipping and cutting out DNA. And so, we actually have in a single mechanism the ability to do bridge editing, if you will, for universal DNA recombination, insertion, excision or inversion, similar to what folks have been doing for decades with Cre recombinase, but with fully programmable recognition sequences. The work that we're doing now in the lab as you can imagine is to adapt these into robust tools for mammalian genome editing, including of course, human genomes. We're excited about this, we're making good progress. The CRISPR has had thousands of labs over the last 10, 15 years working on it to make these therapeutic level potency and selectivity. We're going to work and follow that same blueprint for getting bridge systems to get to that level of performance, but we're on the path and we're very optimistic for the future.Exemplar of Digital BiologyEric Topol (25:13):Yeah, I think it's quite extraordinary and it's a whole different look to what we've been seeing in the CRISPR era for over the past decade and how that's been advancing and getting more specific and less need for repair and being able to be more versatile. But this takes it to yet another dimension. Now, this brings me to the field that when I think of this term digital biology, I think of you and now our mutual acquaintance, Jensen Huang, who everybody knows now. Back some months ago, he wrote and said at a conference, “Where do I think the next amazing revolution is going to come? And this is going to be flat out one of the biggest ones ever. There's no question that digital biology is going to be it. For the first time in human history, biology has the opportunity to be engineering, not science.” So can you critique Jensen? Is he right? And tell us how you conceive the field of digital biology.Patrick Hsu (26:20):If you look at gene therapy today, the core concepts are actually remarkably simple. They're elegant. Of course, you're missing a broken gene, you need to put it back. And that can be curative. Very simple, powerful concept. However, for complex diseases where you don't have just a single gene that goes wrong, in many cases we actually have no idea what to do. And in fact, when you're trying to put in DNA, that's over more than a gene scale. We kind of very quickly run out of ideas. Is it a CAR and a cytokine, a CAR and a cytokine and another thing? And then we're kind of out of ideas. And so, we started thinking in the lab, how can we actually design genomes where it's not just let's reduce the genome into individual Lego blocks, iGem style with promoters and different genes that we just sort of shuffle the Lego blocks around, but actually use AI to design genome sequences.(27:29):So to do that, we thought we would have to first of all, train a model that can learn and decode the foreign language of biology and use that in order to design sequences. And so, we sort of have been training DNA foundation models and virtual cell models at Arc, sort of a major effort of ours where the first thing that we tried was to take a variance of transformer architecture that's used to train ChatGPT from OpenAI, but instead apply this to study the next DNA token, right? Now, the interesting thing about next token prediction in English is that you can actually learn a surprising amount of information by just predicting the next word. You can learn world knowledge is the capital of Azerbaijan, is it Baku or is it London, right? Or if you're walking around in the kitchen, then the next text is, I then left the kitchen or the bathroom, right?(28:33):Now you're learning about spatial reasoning, and so you can also learn translation obviously. And so similarly, I think predicting the next token or the next base and DNA can lead you to learn about molecular biochemistry, is the next amino acid residue, hydrophobic or hydrophilic. And it can teach you about the mechanics of some catalytic binding pocket or something. You can learn about a disease mutation. Is the next base, the sick linked base or the wild type base and so on and so forth. And what we found was that at massive scale, DNA foundation models learn about molecular function, not just at the DNA level, but also at the RNA and the protein. And indeed, we could use these to design molecular systems like CRISPR-Cas systems, where you have a protein and the guide RNA. It could also design new DNA transposons, and we could design sequences that look plausibly like real genomes, where we generate a megabase a million bases of continuous genome sequence. And it really looks and feels like it could be a blurry picture of something that you would actually sequence. This has been a wonderful collaboration with Brian Hie, a PI at Stanford and an Arc investigator, and we're really excited about what we've seen in this work because it promises the better performance with even more scale. And so, simply by scaling up these models, by adding in more compute, more training data or more powerful models, they're going to get sharper and sharper.New A.I. Models in Life ScienceEric Topol (30:25):Yeah. Well, this whole use of large language models for the language of life, whether it's the genome proteins and on and on, actually RNA and even cells has really taken root. And of course, this is really one of the foundations of that field of digital biology, which brings together generative AI, AI tools and trying to push forward our understanding in biology. And also, obviously what's been emphasized in drug discovery, perhaps it's been emphasized even too much because we still have a lot to learn about biology, but that gets me to these models. Like today, AlphaProteo was announced by DeepMind, as we all know, AlphaFold 1, 2, now 3. They were kind of precursors of being able to predict proteins from amino acid 3D structure. And that kind of took the field by a little bit like ChatGPT for life science, but now it's a new model all the time. So you've been working on various models and Arc Institute, how do you see this unfolding? Are we just going to have every aspect of the language of life being approached in all the different interactions? And this is going to help us get to a much more deep level of understanding.Patrick Hsu (31:56):I'll say two things. The first is a lot of models that you just described are what I would call task specific models. A model for de novo design of a binder, a model for protein structure prediction. And there are other models for protein fitness or for RNA structure prediction, et cetera, et cetera. And I think what we're going to move towards are more unifying models where there's different classes of models at different levels of scale. So we will have these atomic level models for looking at generative chemistry or ligand docking. We have models that can unify genomes and their molecules, and then we have models that can unify cells and tissues. And so, for example, if you took an H&E stain of some liver, there are folks building models where you can then predict what the single cell spatial transcriptome will look like of that model. And that's obviously operating at a very different level of abstraction than a de novo protein binder. But in the long run, all of these are going to get, I think unified. I think the reason why this is possible is that biology, unlike physics, actually has this unifying theory of evolution that runs across all of its length scales from atomic, molecular, cellular, organismal to entire ecosystem. And the promise of these models is no short then to make biology a predictive discipline.Patrick Hsu (33:37):In physics, the experimentalists win the big prizes for the theorists when they measure gravitational waves or whatever. But in biology, we're very practical people. You do something three times and do a T-test. And I think my prediction is we can actually gauge the success of these LLMs or whatever in biology by how much we respect theory in this field.The A.I. ScientistEric Topol (34:05):Yeah. Well, that's a really interesting perspective, an important perspective because the proliferation of models, which we're going to get into not just doing the things that you described, but also being able to be “pseudo” scientists, the so-called AI scientist. Maybe you could comment about that concept because that's been the idea that everything from the question that could be asked to the hypothesis and the experiment design and the analysis of data and then the feedback. So what is the role of the scientists, that seems to have been overplayed? And maybe you can put that in context.Patrick Hsu (34:48):So yeah, right now there's a lot of excitement that we can use AI agents not just to do software enterprise workflows, but to be a research assistant. And then over time, itself an autonomous research scientist that can read the literature, come up with an idea, maybe run a bunch of robots in the lab or do a bunch of computational analyses and then potentially even analyze data, conclude what is going on and actually write an entire paper. Now, I think the vision of this is compelling in the long term. I think the question is really about timescale. If you break down the scientific method into its constituent parts, like hypothesis generation, doing an experiment, analyzing experiment and iterating, we're clearly going to use AI of some kind at every single step of this cycle. I think different steps will require different levels of maturity. The way that I would liken this is just wet lab automation, folks have dreamed about having pipetting robots that just do their western blots and do their cell culture for them for generations.(36:01):But of course, today they don't actually really feel fundamentally different from the same ones that we had in the 90s, let's say. Right? And so, obviously they're getting better, but it seems to me one of the trends I'm very bullish about is the explosion of humanoid robots and robot foundation models that have a world model and a sense of physics and proportionate space loaded onto them. Within five years, we're going to have home robots that can fold your clothes, that can organize your kitchen and do all of this while you're sleeping, so you wake up to a clean home every day.Eric Topol (36:40):It's not going to be just Roomba anymore. There's going to be a lot more, but it isn't just the hardware, it's also the agents playing in software, right?Patrick Hsu (36:50):It's the integrated loop of the hardware and the software where the ability to make the same machine generally intelligent will make it adaptable to a broad array of tasks. Now, what I'm excited about is those generally intelligent humanoid robots coming into the lab, where instead of creating a centrifuge or a new type of pipetter that's optimized for your Beckman or Hamilton device, instead you just have robot arms that you snap onto the edge of the bench and then they just work alongside you. And I do think that's coming, although it'll take a lot of hardware and software and computer vision engineering to make that possible.A Sense of HumorEric Topol (37:32):Yeah, and I think also going back to originating the question, there still is quite a debate about the creativity and the lack of any simulation of AGI, whatever that means anymore. And so, the human in the loop part of this is obviously I think it's still of critical nature. Now, the other thing I learned about you is you have a great sense of humor, which is really important by the way. And recently, which is great that you're active on X or Twitter because that's one way we get to see what you're thinking on a day-to-day basis. But I think you put out a poll which was really quite provocative , and it was about, here's what it said, “do more people in the world *truly* understand transformers or health insurance?” And interestingly, you got 49% for transformers at 51% for health insurance. Can you tell us what you're thinking when you put that poll together? Because obviously a lot of people don't understand either of these.Patrick Hsu (38:44):I think the core question is, there are different ways of looking at the world, some of which are very bottom up and some of which are very top down. And one of the very surprising things about transformers is they're taking something that is in principle, an incredibly simple task, which is if you have a string of text, what is the next letter? And somehow at massive, massive scale, you can unlock something that looks an awful lot like reasoning, and you've got these emergent behaviors. Now the bottoms up theory of just the linear algebra that's going on in these models couldn't possibly really help us predict that we have these emerging capabilities. And I think similarly in healthcare, there's a literal set of parts that are operating in some complex way that at massive scale becomes this incredibly confusing and dynamic system for how we can actually incentivize how we make medicines, how we actually take care of people, and how we actually pay for any of this from an economic point of view. And so, I think it was, in some sense if transformers can actually be an explainable by just linear algebra equations, maybe there will be a way to decompose the seemingly incredibly confusing world of healthcare in order to actually build a better way forward.Computing Power and the GPU Arms RaceEric Topol (40:12):Yeah. Well that's great. Now the other thing I wanted to ask you about, we open source and the arms race of GPUs and this whole kind of idea is you touched on the need for coalescing a lot of these tools to exploit the synergy. But we have an issue because many academic labs like here at Scripps Research and so many others, including as I learned even at Stanford, have limited access to GPUs. So computing power of large language models is a problem. And then the models that exist today that can be adopted like Llama or others, and they're somewhat limited. And then we also have a movement towards trying to make things more open source, like for example, recently OpenCRISPR with Profluent Bio that is basically trying to use AI for CRISPR guides. And so, how do you deal with this arms race, computing power, open source, proprietary models that are not easily accessible without a lot of resources?Patrick Hsu (41:30):So the first thing I would say is, we are in the academic science sphere really unprepared for the level of resources that are required for doing this type of cutting edge computational work. There are top Stanford computer science professors or computational researchers who have a single GPU in their office, and that's actually what their whole lab runs off of.(41:58):The UC Berkeley campus, the grid runs on something like 12 megawatts of power and how are they going to build an on-premises GPU clusters, like a central question that can scale across the entire needs? And these are two of the top computer science universities in the world. And so, I think one of our kind of core beliefs at Arc is, as science both experimentally and computationally has gotten incredibly complex, not just in terms of conceptually, but also just the actual infrastructure and machines and know-how that you need to do things. We actually need to essentially support this. So we have a private GPU cloud that we use to train our models, and we have access to significantly large clusters for large burst kind of train outs as necessary. And I think infrastructurally for running genomics experiments or doing scalable brain organoid screens, right, we're also building out the infrastructure to support that experimentally.Eric Topol (43:01):Yeah, no, I think this is one of the advantages of the new model like the Arc Institute because not many centers have that type of plasticity with access to computing power when needed. So that's where a brilliant mind you and the Arc Institute together makes for a formidable recipe for future advances and of course building on the ones you've already accomplished.The Primacy of Human TalentPatrick Hsu (43:35):I would just say, my main skill, if I have one, is to recruit really, really smart people. And so, everything that you're seeing and hearing about is the work of unbelievable colleagues who are curious, passionate, and incredible scientists.Eric Topol (43:53):But it also takes the person who can judge those who are in that category set as a role model. And you're certainly doing that. I guess just in closing, I mean, it's just such a delight to get to meet you here and kind of get your thoughts on what is the hottest thing in life science without question, which brings together the fields of AI and what's going on, not just obviously in genome editing, but this digital biology era that we're still in the early phases of, I mean, I think you could say that it's just going to continue to accelerate the exponential curve. We're still kind of on the bottom of that, I would imagine where we're headed. Any other things that you want to bring up that I haven't touched on that will round out this conversation?Patrick Hsu (44:50):I mean, I think it's very early days here at Arc.Patrick Hsu (44:53):When we founded Arc, we asked ourselves, how do we measure success? We don't have customers or revenue in the way that a typical startup does. And we felt sort of three things. The first was research institutes live and die by their talent. Can we actually hire incredible people when we make offers to people we want to come, do they come? The second was, when those folks do come to Arc, do they feel like they're able to work on important research programs that they couldn't do sort of at their prior university or company? And then longer term, the third thing was, and there's just no shortcut around this, you need to do important work. And I think we've been really excited that there are early signs that we're able to do all three of these things, and we're still, again, just following the same scaling laws that we're seeing in natural language and vision, but for the domain of biology. And so, we're excited about what's ahead and think if there are folks who are interested in learning more about Arc, just shoot me an email or DM.Eric Topol (46:07):Yeah, well I would just say, congratulations on what you've already achieved. I know you're going to keep rocking it because you already have in a short time. And for anybody who doesn't know about Arc Institute and your work and your team, I hope this is going to be putting them on notice actually what can be accomplished outside of the usual NIH funded model, which is kind of a risk-free zone where you basically have to have your results nailed down before you send in your proposal frequently, and it doesn't do great things for young people. Really, I think you actually qualify in that demographic where it's hard for them to break in for getting NIH grants and also for this type of work that you're doing. So we'll look for the next bridge beyond bridge RNAs of your just fantastic efforts. So Patrick, thanks so much for joining us today, and we'll be checking back with you and following all the great work that you'll be doing in the times ahead.Patrick Hsu (47:14):Thanks so much, Eric. It was such a pleasure to be here today. Appreciate the opportunity.*******************Thanks for listening, reading or watching!The Ground Truths newsletters and podcasts are all free, open-access, without ads.Please share this post/podcast with your friends and network if you found it informative!Voluntary paid subscriptions all go to support Scripps Research. Many thanks for that—they greatly help fund our summer internship programs.Thanks to my producer Jessica Nguyen and Sinjun Balabanoff for audio and video support at Scripps Research.Note: you can select preferences to receive emails about newsletters, podcasts, or all I don't want to bother you with an email for content that you're not interested in. Get full access to Ground Truths at erictopol.substack.com/subscribe

Vanished Without A Trace: The Tara Calico Disappearance!Become a supporter of this podcast: https://www.spreaker.com/podcast/missing-persons-mysteries--5624803/support.

Mark and Scott take on two games of the Flatout Trilogy, Calico and Cascadia, and break down the way the games work, why they like the one they do, and what they don't enjoy in the other. At the end of the episode, they also give a recommendation to explore similar games.   This episode's segments: 00:00:00 - Intro  00:00:55 - Calico vs. Cascadia 00:16:56 - Recommendations / Outro You can email us at boardallthetimegaming@gmail.com. We can be found at www.boardallthetime.com and on Facebook at Board All The Time.  If you'd like to help support the show and assist with the hosting costs, you can do so with our Ko-Fi: https://ko-fi.com/boardallthetime Our Discord server, which is still in Beta, can be joined at https://discord.gg/VbRWEpc6 We'd like to thank our sponsors as well: Robin's Nerd Supply: www.robinsnerdsupply.com Eco Owl Press: www.ecoowlpress.com  We'd also like to thank SoulProdMusic for the intro/outro music. 

I recorded this song using a Deering Calico banjo. I love my Calico, it has more resonance than any banjo I've played so far. It might be too thin and bright for recording, for some musicians. I personally think Deering's Golden Era series is best for recording, but for just picking I love the Calico! I'm using Dave Hum's backing track, which you can purchase on his website. Enjoy!

Our guest in this episode is Karl Pfleger. Karl is an angel investor in rejuvenation biotech startups, and is also known for creating and maintaining the website Aging Biotech Info. That website describes itself as “Structured info about aging and longevity”, and has the declared mission statement, “Everything important in the field (outside of academia), organized.”Previously, Karl worked at Google from 2002 to 2013, as a research scientist and data analyst, applying AI and machine learning at scale. He has a BSE in Computer Science from Princeton, and a PhD in Computer Science and AI from Stanford.Previous London Futurists Podcast episodes mentioned in this conversation:Ep 74: The Longevity Singularity, with Daniel IvesEp 45: Generative AI drug discovery breakthrough, with Alex ZhavoronkovEp 12: Pioneering AI drug development, with Alex ZhavoronkovOther selected follow-ups:AgingBiotech.InfoLifespan.io rejuvenation roadmapAgingDB listStealth BiotherapeuticsNewLimitJuvenityJuvena TherapeuticsImmunisPartnership between Calico and AbbVieHevolutionUnity BiotechnologyHere's Why resTORbio Fell Over 83% TodayA4LI Responds to NIH Reform ProposalGreat Desire for Extended Life and Health amongst the American Public - a paper by Karl Pfleger. Kristen Fortney, Joe Betts-LaCroix and others, LEV achieved for young people before it is achieved for old peopleLongevity Biotech FellowshipForesight InstituteLongevity GlobalVitalism.IOMusic: Spike Protein, by Koi Discovery, available under CC0 1.0 Public Domain Declaration

This week, the story of 3 pirates unfolds before us! Join us as we learn all about Anne Bonny, Mary Read, & Calico Jack.

Vanished Without A Trace: The Tara Calico Disappearance!Become a supporter of this podcast: https://www.spreaker.com/podcast/missing-persons-mysteries--5624803/support.

Board Boys are back, baby, to play Evenfall from new dev Stefano de Silva as well as chat with pal David Kuntz about this year's Capital City Gaming Con (formerly Cardboard Caucus) coming up Oct 11-13 0:00 Intro, E.V.A. - Jean Jacques Perrey  12:00 Capital City Gaming Con Preview w/David Kuntz 23:30 Ziggurat  26:45 Arcs 29:45 Cats and Quilts of Calico 36:45 Bomb Busters 40:15 Evenfall: Overview 44:15 Bring Me To Life - Evanescence (karaoke from Bob and Bev) 45:15 Evenfall: Review 1:13:00 Evenfall: Verdict 1:19:30 Board Boys Bump: The Wolves 1:26:15 Ain't No Stoppin' Us Now - DJ Steve Walsh  

GGG 346 Cyberpunk Gauntlet - This week we talk history drones 5.7, Calico, and the gunfighter gauntlet match.  DJI Neo 5.7 Sub2000 Calico Calico Mac Conversion kit 80's Lasers Gunfighter Gauntlet Twitch Channel Instagram (Matt) Instagram (Heinrich) LFD Research Youtube LFD Research Playur Facebook Apple Podcasts Stitcher  Contact the show directly at geeksgadgetsandguns@gmail.com

Vanished Without A Trace: The Tara Calico Disappearance!Become a supporter of this podcast: https://www.spreaker.com/podcast/missing-persons-mysteries--5624803/support.

Welcome to episode 67! In this episode we get caught up on some of the games we've been playing lately plus games we're excited about! Games we've been playing lately: A Gest of Robin Hood - 00:04:18 Sea Dragons - 00:24:53 SpellBook - 00:31:52 Potion Explosion: Tonic of Glacial Preservation - 00:37:46 Seers Catalog - 00:43:55 CuBirds - 00:53:24 Colosseum - 00:58:44 Exit The Game: The Hunt Through Amsterdam - 01:09:10 Calico - 01:17:20 Things we're excited about - 01:28:10: Cthulhu Death May Die (Fear of the Unknown) Mistborn: Deckbuilding Game Ascension Star Wars Unlimited: Shadows of the Galaxy Unconscious Mind Join our Discord: https://discord.gg/F4kX3Faxxf  Other links : https://linktr.ee/Longestturn Affiliate codes: GameNerdz, Boardlandia (5% discount) Support us on Buy Me a Coffee!

I was skeptical about whether "Virtual Care" would be a good service for home care agencies, but I was proven wrong.  In summary, this is a great way to differentiate your agency and to add a high-margin service.  Our guest is Stephan Habermeyer who is the CEO at Calico.Care. Here are some highlights of what we learned:Virtual Care provides a way to monitor the well-being of home care clients throughout the day and night.Some agencies are using this for the classic scenario where the family wants home care for their mom, but the mom is not ready. They combine the virtual care with visits (live and/or virtual) from a care coordinator (at a high charge) and usually within a short time, the client agrees to add caregiver hours.The margins are high. As an example, some agencies are charging $1/hour for virtual care ($720 a month) and the cost is generally $200. Other agencies are charging $1,000/month or more.Another way that agencies are deploying the service is to add virtual care to a 30 or 40 hour a week client.The basic system comes with motion sensors and an Amazon Alexa. Plus the system comes with its own internet (no need to connect to wifi)Everything comes in a preconfigured kit and the devices are labeled, plus they walk the home care agency through it on facetime.  All they need to do is plug in two plugs and stick the sensors on the wall. Batteries will need to be replaces in around 2 years (but by that time, you'll have made $15,000.The family gets to monitor their own loved one with an app, but agencies are also providing a monitoring service by paying overnight caregivers an extra fee for monitoring.Bottom line, this looks like a great way to add high-margin revenue and to differentiate your service from competitors.To learn more about the solution, go to the website https://www.calico.care/ or email them at info@calico.care. Home Care Heroes and Day Service Stars is produced and sponsored by Ankota - If you provide services that enable older or disabled people to continue living at home , Ankota can provide you the software to successfully run your agency. Visit us at https://www.ankota.com. 

Here's to friendship on the Irish & Celtic Music Podcast #671 . Subscribe now! Hanneke Cassel, Old Blind Dogs, Wylde Nept, Conor Mallon, Tarren, Ironwood, Jesse Ferguson, Runa, CaliCeltic, The Town Pants, The Fire, Bealtaine, The Elders, Vicki Swan & Jonny Dyer GET CELTIC MUSIC NEWS IN YOUR INBOX The Celtic Music Magazine is a quick and easy way to plug yourself into more great Celtic culture. Enjoy seven weekly news items for Celtic music and culture online. Subscribe now and get 34 Celtic MP3s for Free. VOTE IN THE CELTIC TOP 20 FOR 2024 This is our way of finding the best songs and artists each year. You can vote for as many songs and tunes that inspire you in each episode. Your vote helps me create next year's Best Celtic music of 2024 episode. You have just three weeks to vote this year. Vote Now! You can follow our playlist on Spotify to listen to those top voted tracks as they are added every 2 - 3 weeks. It also makes it easier for you to add these artists to your own playlists. You can also check out our Irish & Celtic Music Videos. THIS WEEK IN CELTIC MUSIC 0:06 - Hanneke Cassel "The Captain" from Dot the Dragon's Eyes 4:39 - WELCOME 8:43 - Old Blind Dogs "Suite Bretonne" from Knucklehead Circus 12:51 - Wylde Nept "Between Moonbeams" from All's Fair 15:35 - Conor Mallon "One Four Four" from Unearthed 20:03 - Tarren "Searching for Lambs" from Revel 22:39 - FEEDBACK 28:17 - Ironwood "Lovelace" from Gretna Green 33:20 - Jesse Ferguson "Skye Boat Song" from The Bard of Cornwall 37:09 - Runa "Liam's Lullaby" from When The Light Gets In 39:25 - CaliCeltic "Steam Beer" from Whiskey Mustache 42:34 - THANKS 44:35 - The Town Pants "Something to Say" from Something to Say 47:47 - The Fire "Rip the Calico" from Marigold 51:56 - Bealtaine “Tears in your Beer” from The Founders' Room Vol 2 56:17 - The Elders "Common Man" from Wanderin' Life & Times 59:51 - CLOSING 1:00:53 - Vicki Swan & Jonny Dyer "We Were Friends" from Paper of Pins 1:05:39 - CREDITS The Irish & Celtic Music Podcast was produced by Marc Gunn, The Celtfather and our Patrons on Patreon. The show was edited by Mitchell Petersen with Graphics by Miranda Nelson Designs. Visit our website to follow the show. You'll find links to all of the artists played in this episode. Todd Wiley is the editor of the Celtic Music Magazine. Subscribe to get 34 Celtic MP3s for Free. Plus, you'll get 7 weekly news items about what's happening with Celtic music and culture online. Best of all, you will connect with your Celtic heritage. Please tell one friend about this podcast. Word of mouth is the absolute best way to support any creative endeavor. Finally, remember. Reduce, reuse, recycle, and think about how you can make a positive impact on your environment. Promote Celtic culture through music at http://celticmusicpodcast.com/. WELCOME THE IRISH & CELTIC MUSIC PODCAST * Helping you celebrate Celtic culture through music. I am Marc Gunn. This podcast is for fans of Celtic music. My goal is to build a diverse Celtic community and help the incredible artists who so generously share their music with you. If you hear music you love, please email artists to let them know you heard them on the Irish and Celtic Music Podcast. Musicians depend on your generosity to keep making music. So please find a way to support them. Buy a CD, Album Pin, Shirt, Digital Download, or join their communities on Patreon. You can find a link to all of the artists in the shownotes, along with show times, when you visit our website at celticmusicpodcast.com. IrishFest Atlanta takes place Nov 8 - 10, 2024 with headliners Cherish the Ladies and The Friel Sisters. You can grab tickets to watch these concerts or enjoy tons of other great entertainment.  Go to https://www.irishfestatlanta.org/ for details. IrishFest Atlanta, which offers ticketed events and FREE programming for the public, includes: Traditional Irish music, song, dance, language, sports, films Workshops in music, dance and language A traditional Irish tea, whiskey - tasting, and an Irish bread - making competition Free family events including an Irish dance (Céilí), arts and crafts, and sports. Go to https://www.irishfestatlanta.org for more event information. If you are a Celtic musician or in a Celtic band, then please submit your band to be played on the podcast. You don't have to send in music or an EPK. You will get a free eBook called Celtic Musicians Guide to Digital Music and learn how to follow the podcast. It's 100% free. Just email Email follow@bestcelticmusic and of course, listeners can learn how to subscribe to the podcast and get a free music - only episode. Plastic Free July. Plastic Free July® is a global movement that helps millions of people be part of the solution to plastic pollution – so we can have cleaner streets, oceans, and beautiful communities. Will you be part of Plastic Free July by choosing to refuse single - use plastics? THANK YOU PATRONS OF THE PODCAST! You are amazing. It is because of your generosity that you get to hear so much great Celtic music each and every week. Your kindness pays for our engineer, graphic designer, Celtic Music Magazine editor, promotion of the podcast, and allows me to buy the music I play here. It also pays for my time creating the show each and every week. As a patron, you get ad - free and music - only episodes before regular listeners, vote in the Celtic Top 20, stand - alone stories, you get a private feed to listen to the show or you can listen through the Patreon app.  All that for as little as $1 per episode. A special thanks to our Celtic Legends: Bruce, Brian McReynolds, Marti Meyers, Brenda, Alan Schindler, Karen DM Harris, Emma Bartholomew, Dan mcDade, Miranda Nelson, Nancie Barnett, Kevin Long, Gary R Hook, Lynda MacNeil, Kelly Garrod, Annie Lorkowski, Shawn Cali HERE IS YOUR THREE STEP PLAN TO SUPPORT THE PODCAST Go to our Patreon page. Decide how much you want to pledge every week, $1, $5, $25. Make sure to cap how much you want to spend per month. Keep listening to the Irish & Celtic Music Podcast to celebrate Celtic culture through music. You can become a generous Patron of the Podcast on Patreon at SongHenge.com. TRAVEL WITH CELTIC INVASION VACATIONS Every year, I take a small group of Celtic music fans on the relaxing adventure of a lifetime. We don't see everything. Instead, we stay in one area. We get to know the region through its culture, history, and legends. You can join us with an auditory and visual adventure through podcasts and videos. Learn more about the invasion at http://celticinvasion.com/ #celticmusic #irishmusic #celticmusicpodcast I WANT YOUR FEEDBACK What are you doing today while listening to the podcast? Please email me. I'd love to see a  picture of what you're doing while listening or of a band that you saw recently. How are you listening to this podcast? I'd love to know that as well. The show is available on a bunch of podcast apps like Apple Podcast, Amazon Music, Podcast Addict, iHeartRadio, Player.FM, Pocket Casts, Cast Box, Pandora, Podbean, and my favorite Overcast Email me at follow@bestcelticmusic. Margaret and Bill Sneddon emailed a photo from Connecticut: "Hi, Marc, Enjoying your podcast aboard our sailboat, Isle of Skye, docked today at Pilot's Point in Westbrook, CT" Peter Wood replied to a post on Facebook: "So I'm sitting here listening to the podcast on Pocket Casts as I have for years and I hear that Podcast Addict, Amazon Music, and Patreon are the only Android apps you can listen to the show on? There's still an RSS feed easily linked on the website too, so any non - cloud based podcatcher should be able to subscribe too. I recently installed AntennaPod because I'm considering moving from Pocket Casts and I see this show among my imported subscriptions like any other." Corey Fitch emailed: "Hi Marc, I've been listening to your podcast for the past year or so and its been keeping me great company on my drive to work! We had a big family celebration last year. It was our 250th anniversary on our small family farm in New Hampshire—my kids are the 10th generation living on the farm. For musical entertainment, we had the Jordan TW Trio (led by Jordan Tirrell - Wysocki) and they were absolutely fantastic—everyone was up dancing and they ended the night with an beautiful acapella Parting Glass. I haven't heard them on the podcast yet so I figured I would put the plug in to get them in the rotation. Thank you for everything you do!"

Welcome! Jenna and Rachel discuss tabletop games we have been playing, games we are excited to play, and other nerdy news!Games RadarRaising RobotsCalicoGames ForecastShipwreck ArcanaRats of WistarOther Nerdy NewsLorcanaPaliaPlease reach out to us at friendlylgpmail@gmail.com, we would love to hear from you!

In this episode we sail round the Horn and back again as we look into the lives, trial and mysteries of the Naussau Pirates Anne Bonny and Mary Read.  Part of Calico Jack Rackham's crew, these two dressed as men, cursed, drank, fought and killed with their pirate brethren and for two months lived completely free, a rare thing for women in the Early 1700's.  We dig into what little is known about their early lives, what led them to become pirates and how their two months as lawless pirates made them so famous they are still talked about to this day.  Laura has Covid AND the Flu, she never does anything by halves.  Arthur discusses people mocking the trans movement by identifying as helicopters and toasters and in the end, we are forced to admit that Anne Bonny disappeared sometime after she had been imprisoned on the Bahamas and we do not know how or where her life ended.  So join us for this special episode all about these two pirates and so much more in this Jolly Roger Episode of the Family Plot Podcast!Become a supporter of this podcast: https://www.spreaker.com/podcast/family-plot--4670465/support.

Send us a Text Message.After learning to play guitar at age 17 in the mid 1960s, Dave Van Amburg would spend the next 11 years playing solo and in bands such as Back Country Jam and Calico. Then he took a 40-year break from music. In 2013, he began playing again in bands such as 2Blue, Bootlegger Bible Club, Matty B & the Dirty Pickles, House of Rhythm, The V Band, and others, and he hasn't let up. Listen to Dave's fascinating and inspiring musical journey in episode 78.Thanks to the JPT Foundation for sponsoring the Erie Music History podcast. The goal of the foundation is to provide education scholarships to grade school-age children as well as annual giving to local organizations and charities. The foundation has a large hall that hosts bingo four days a week and is available for rentals, and it is also the home of this podcast's monthly music night, which is the first Tuesday of the month from 6PM-9PM.  Many thanks to folks like Angelo Phillips, Tom Lane, and Mike Miller who have donated to the podcast. If you would like to help out, Venmo me at @Dan-Schell-6. For information on what bands/musicians are playing in Erie, PA and the surrounding area, please check out Jack Stevenson's 2 Man Happy Hour podcast and webpage.www.ErieMusicHistory.comhttps://www.facebook.com/ErieMusicHistoryPodcast

Aurora Reservoir has banned alcohol and loud music. Jamie got sprayed tanned yesterday and she looks like a Calico cat. 

Hour 3 - Aurora Reservoir has banned alcohol and loud music. Jamie got sprayed tanned yesterday and she looks like a Calico cat. Today is national donut day! 

Capt. Ben Florentino joins BTL Guide Day to talk about catching bass from the salt in California.  

Former gamer turned prepper says quit gaming, Princess Peach: Showtime!, Unicorn Overlord, Tribes 3 Rivals, Steller Blade Demo drama, Dragons Dogma 2 Character Creator and Storage Demo, Backpack Battles, Quilts and Cats of Calico, Call of Duty WWII prep map, upcoming games, consoles and exclusives are dead says IGN. For weekly bonus shows and the entire back catalog of VGO, support us for only 1.99 a month and download or listen on the web at ilovevgo.com or on the free VGO mobile apps for iOS/Android! Sub and support on VideoGameOutsiders.com right now! We also have a Patreon.com/videogameoutsiders to be listed as a supporter, sponsor an episode, or more! You can also join our Discord and enter to win Dragon's Dogma 2!

This episode we get to talk with the guys about Sea Bass, Calico ,Halibut ,Poop Stories , Beer and Fishing . Check out Vikingheads @https://vikingheads.com Learn more about your ad choices. Visit megaphone.fm/adchoices