Podcasts about penetrating

ASMR Tingly Brain Penetrating Invisible Triggers Mic PullingAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

It's Vesper's turn to pay the Ferry Man's toll. Can she and Edwin be trusted? The gang sails to Holovail and meets a whole new weird kind of entity - in a town that Zippy swore never to return to....This episode contains swearing, the tip of the rim, and some frankly extreme bullying of a perfectly innocent Edwin. Listener discretion advised.Support the show

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Hebrews 4:11-13

Label: Afterme Cat: DAM39 Format: Digital Released: 31 December 24 Genre: House Style: Minimal Tracklist: 1. Gudj - Lilypad (Original Mix) 2. Gudj - Fashionable (Original Mix) 3. Gudj - Sis (Original Mix) 4. Gudj - Fashionable (Canavezzi Remix) Artists: https://soundcloud.com/user-gudj https://www.instagram.com/maxgudj/ https://www.facebook.com/profile.php?id=61553649034877 Label: https://soundcloud.com/labelafterme https://www.facebook.com/labelafterme https://www.instagram.com/labelafterme/ Support&buy: https://labelafterme.bandcamp.com/album/gudj-dam39 Description: [DAM39] The new release from Gudj is a sonic journey through airy, technical textures that fill the space with a soft minimalist sound. Penetrating bass and deep pads transport the listener to an atmosphere where every element sounds thoughtful and precise, like the details of a mechanism. The remix by Canavezzi adds a new perspective to the sound, bringing fresh ideas while preserving Gudj's signature style. Dive into this release and discover the sonic palette of Manchester. Mastering by Kashatskikh Studio, Saint-Petersburg (RU) Design & Illustration by Kirill Kashatskikh

This week Landon, Jeremiah, and Steph get drunk and answer listener questions, while a sober Mike hosts. Don't listen to this one with kids. Questions and topics include:- Our most cancel-able Austin FC takes- The soccer field version of the "mile high club"- Lots of F/M/K matchups - Guessing Fagundez tattoos- Players as the Scooby-Doo gang - So much moreRemember to rate, review, and subscribe to the show at moontowersoccer.com or via your favorite podcasting app.Moontower Soccer is brought to you by FVF Law and McGuire Woods ConsultingSupport the show

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In This Hour:--  Aerokoil as a last-ditch option for breaking loose stuck parts.--  Purse snatching increases during the holidays, and sometimes there's a gun in the purse.--  Ways for women to carry guns securely. Gun Talk 12.22.24 After Show

BUFFALO, NY - December 11, 2024 – A #news feature on the #research paper “Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition” by Rackear et al. was #published in Oncotarget's Volume 15 on November 22, 2024, titled “Advancements in cell-penetrating monoclonal antibody treatment." This new publication by Sai Pallavi Pradeep and Raman Bahal from the Department of Pharmaceutical Sciences at the University of Connecticut highlights significant advancements in monoclonal antibody (mAb) therapies. The focus is on the 3E10 antibody, originally derived from autoimmune mouse studies in systemic lupus erythematosus. Unlike traditional mAbs, which struggle to reach intracellular targets, this cell-penetrating antibody targets cancer cells by addressing a major limitation of current therapies. By targeting RAD51, a key intracellular protein involved in DNA repair, the 3E10 antibody shows great promise for cancer treatment, particularly in cancers with defective DNA repair pathways. mAbs have already changed the landscape of cancer therapy, offering treatments that are more targeted and have fewer side effects compared to chemotherapy. However, current therapies are limited since mAbs only target proteins on the surface of cancer cells. This research pushes the boundaries by demonstrating how 3E10 antibodies can penetrate cells and access their internal molecules. This unique capability expands the potential of mAb therapies and targeted cancer treatments. Different humanized versions of the 3E10 antibody were created and carefully tested. Some versions were particularly effective at blocking RAD51, while others showed promise for carrying other therapeutic molecules like genetic material into the cancer cells. This flexibility means that 3E10 could be used to treat different cancer types and deliver various therapeutic molecules directly into tumor cells. This progress offers exciting new possibilities for treating cancer tumors that are resistant to conventional therapies. In conclusion, the 3E10 antibody's dual function—targeting DNA repair pathways and delivering therapeutic molecules—positions it as a transformative tool in cancer research and targeted cancer treatments. DOI - https://doi.org/10.18632/oncotarget.28674 Correspondence to - Raman Bahal - raman.bahal@uconn.edu Video short - https://www.youtube.com/watch?v=3uMdPvThFHA Sign up for free Altmetric alerts about this article: https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28674 Subscribe for free publication alerts from Oncotarget: https://www.oncotarget.com/subscribe/ Keywords - cancer, monoclonal anti-bodies, cell penetration, nucleic acid delivery, 3E10 About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

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In Part 2 of this series, Miyanovich and Yamane discuss: The Miyan-Starr-Yamane Borg-mind Weapon for social evolution, penetrating the mainstream media in an unprecedented way, the negatives of pleasing others, dealing with insecurities, same but different, Hitler's nuts redux, getting back-up from your compadres, critical morale boosts, Koi no Taki Nobori, and David's first ever F-word on the podcast.

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Harry sits down with Rick Wilson, co-founder of the Lincoln Project and a former Republican political strategist who did as much as anyone to warn the country of the dangers of a Trump presidency, including creating and distributing a dazzling series of ads that brought home Trump's essential know-nothingness, hypocrisy, and wickedness. The two begin with a discussion of whether in retrospect the election was winnable for Harris-Walz, or whether the forces that propelled Trump's victory were in retrospect insuperable. Wilson analyzes the result in terms of the media ecosystem that the extreme right has constructed and made common cause with since 2008 and especially since Covid. Penetrating that ecosystem is the chief task going forward, but it is way easier said than done. Trump's likely stumbles as President will provide some headway and perhaps provide openings for the Democrats to take back one of the Houses of Congress in 2026. But the immediate and pressing issue is whether Trump will use his virtually unchecked power to move the country towards autocracy along the model of say, Turkey, in a way that history demonstrates is very hard to reverse. That leaves little choice of patriots, who might well have been looking forward to a resumption of normal life and normal politics, than to continue to fight day to day and month to month against the coming waves of abuses of governmental power.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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In this episode of the PFC Podcast, Dennis and JP Kolcun, a neurosurgery resident, delve into the complexities of spinal trauma. They discuss the differences between spinal shock and neurogenic shock, the assessment and management of penetrating and blunt spinal injuries, and the critical importance of addressing secondary injuries. The conversation emphasizes the need for timely intervention and the nuances of trauma care in both field and hospital settings. This conversation delves into the complexities of spinal cord injury treatment, emphasizing the importance of timely surgical decompression, understanding spinal cord perfusion, and the role of intrathecal pressure. The discussion highlights the need for optimizing spinal cord perfusion pressure and the implications of using vasopressors. Innovations in treatment, including the potential for intrathecal medication delivery and advancements in brain-computer interfaces, are explored as future avenues for improving patient outcomes. Takeaways Spinal shock is a neurologic phenomenon, while neurogenic shock is hemodynamic. Penetrating spinal cord injuries are often more severe than blunt injuries. Immediate stabilization and ABCs are crucial in trauma care. Understanding the difference between spinal shock and spinal cord injury is vital. Secondary injury can worsen outcomes if not addressed promptly. Timely decompression of the spinal cord can improve recovery chances. Assessment of spinal stability is essential in blunt trauma cases. The presence of a bulbocavernous reflex can indicate spinal cord injury. Norepinephrine is preferred for treating neurogenic shock. Avoid hypotension to prevent further complications in spinal injuries. The timing of surgical decompression can significantly impact recovery. Surgical decisions must consider the overall health of the patient, not just the injury. Spinal cord perfusion is critical for recovery post-injury. Intrathecal pressure varies and can affect spinal cord perfusion. Targeting spinal cord perfusion pressure may improve outcomes over traditional MAP goals. Vasopressors can constrict blood vessels, potentially reducing perfusion to the spinal cord. Innovative treatments, such as lumbar drains, can enhance spinal cord perfusion. Research is ongoing into the use of intrathecal medications for spinal cord injury. The ultimate goal is to improve quality of life for spinal cord injury patients. Advancements in technology may lead to breakthroughs in treating chronic spinal cord injuries. Thank you to Delta Development Team for in part, sponsoring this podcast. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠deltadevteam.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ For more content go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.prolongedfieldcare.org⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠ Consider supporting us: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠patreon.com/ProlongedFieldCareCollective⁠⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠⁠www.lobocoffeeco.com/product-page/prolonged-field-care⁠

The American fine art photographer Tina Barney is known for giving us a glimpse into the soul of her subjects, deftly capturing a passing glance, a wistful gaze or a confident look. The artist has been honing that singular perspective from behind her traditional tripod set-up for more than four decades. As her exhibition "Family Ties" goes on show at the Jeu de Paume gallery in Paris, she speaks to us about returning to familiar subject matter, documenting the rites and rituals of the American upper classes and why she thinks the Instagram age is "pretty horrific" for photography.

BUFFALO, NY- October 21, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on October 1, 2024, entitled, “Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition.” As highlighted in the abstract, monoclonal antibody therapies for cancer have shown extraordinary clinical success in recent years. However, these strategies are primarily limited to targeting specific cell surface antigens, despite many disease targets being located intracellularly. In their paper, researchers Madison Rackear, Elias Quijano, Zaira Ianniello, Daniel A. Colón-Ríos, Adam Krysztofiak, Rashed Abdullah, Yanfeng Liu, Faye A. Rogers, Dale L. Ludwig, Rohini Dwivedi, Franziska Bleichert, and Peter M. Glazer from the Departments of Therapeutic Radiology and Genetics at Yale University School of Medicine, Gennao Bio, and the Department of Molecular Biophysics and Biochemistry at Yale University report on the humanization of the full-length, nucleic acid-binding monoclonal lupus-derived autoantibody 3E10, which exhibits a novel mechanism for cell penetration and tumor-specific targeting. The authors compare humanized variants of 3E10 and demonstrate that cell uptake relies on the nucleoside transporter ENT2. They also find that faster cell uptake and superior in vivo tumor targeting are associated with higher affinity nucleic acid binding. “We show that one human variant retains the ability of the parental 3E10 to bind RAD51, serving as a synthetically lethal inhibitor of homology-directed repair in vitro.” DOI - https://doi.org/10.18632/oncotarget.28651 Correspondence to - Peter M. Glazer - peter.glazer@yale.edu Video short - https://www.youtube.com/watch?v=sTHjJ0Qq0YQ Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28651 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, 3E10, cell penetration, nucleic acid binding, nucleic acid delivery, RAD51 About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

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ASMR Brain Penetrating Unpredictable Invisible Triggers Mic Pulling (Whispering）Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

ASMR Brain Penetrating 3D Tapping (No Talking)Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

ASMR Brain Penetrating Unpredictable Invisible Triggers Mic PullingAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

ASMR Cerebral Penetrating Scratching Triggers for Strong TinglesAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

ASMR Most Tingly Brain Penetrating Tapping for Instant Sleep Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

ASMR Tingly Brain Penetrating Tapping (No Talking)Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

ASMR Most Tingly Brain Penetrating Tapping for Instant Sleep Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

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Take Home Points Anticipate anatomically challenging airways and consider early intubation prior to loss of airway anatomy. Skip the zones of the neck and focus on hard signs of vascular (Shock w/o another source, Pulsatile bleeding, Expanding hematoma, Audible bruit, Signs of stroke) or aerodigestive (Airway compromise, Bubbling wound, Extensive SubQ air, Stridor, Significant hemoptysis/hematemesis). ... Read more The post REBEL Core Cast 127.0 – Penetrating Neck Injuries appeared first on REBEL EM - Emergency Medicine Blog.

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Penetrating and blunt trauma are bread and butter for most emergency physicians. Let's cover the rare, but scary presentation of traumatic arrest. Want to experience the greatest in board studying? Check out our interactive question bank podcast- the FIRST of its kind here. Cite this podcast as: Briggs, Blake; Husain, Iltifat. 232. Trauma Arrest. August 25th, 2024. Accessed [date].

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ASMR Tingly Brain Penetrating Invisible Triggers Mic PullingAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Dr. Matt Feng is joined by Dr. Thomas H. Dohlman to discuss the effectiveness of topical and subconjunctival bevacizumab in suppressing vascularization in graft and host bed after high-risk corneal transplantation, from his Ophthalmology Science article “Suppression of Neovascularization by Topical and Subconjunctival Bevacizumab After High-Risk Corneal Transplantation” Suppression of Neovascularization by Topical and Subconjunctival Bevacizumab After High-Risk Corneal Transplantation. Dohlman, Thomas H. et al. Ophthalmology Science, Volume 4, Issue 4.

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Continuing this season's theme of surgical horror stories, Neda Shamie, MD, joins Gary Wörtz, MD, to share an experience from early in her career when she faced an unexpected complication. While performing penetrating keratoplasty on a well-known patient, Dr. Shamie encountered an expulsive hemorrhage. She highlights the value of mentorship in these situations and having a trusted colleague to help shape one's approach to stressful complications during surgery. She also emphasizes the importance of learning from these situations and gaining new surgical skills.

Welcome to the Car Dealership Guy Podcast. In this episode, I'm speaking with Charles Mizrahi, Head of Automotive Partnerships at Uber, where we discuss evolving the customer experience at dealerships, killing the courtesy shuttle, how dealers hacked Uber, and much more! This episode of the Car Dealership Guy Podcast is brought to you by: AutoFi - AutoFi solves the everyday problems dealers face like bottlenecks at the sales desk, customer distrust, and decision overload. Their all-new showroom solution includes deal estimation, desking, lender routing, and an F&I menu all in one powerful Platform. Learn more @ https://www.autofi.com/cdg/ Uber for Business - With Central, you can request a ride on behalf of your customers even if they don't have the Uber app. If you're ready to reduce the costs associated with maintaining shuttles and limit the liability of loaner vehicles, it's time to partner with Uber. Visit t.uber.com/CDGauto today  Car Dealership Guy News - The #1 source for concise and unbiased car industry news. Stay informed with the most relevant and interesting stories by visiting https://cdg.news Interested in advertising with Car Dealership Guy? Drop us a line here Interested in being considered as a guest on the podcast? Add your name here Topics: (00:00:00) - Intro (00:03:15) - Charlie's background and career (00:04:42) - Ideating Uber for Business (00:10:42) - Penetrating the car business during Covid (00:12:16) - What are you working on today?  (00:14:59) - What's the value of offering a service that is so simple on the surface? (00:18:25) - What are the use cases for this product? (00:21:17) - What's the future for dealership transportation? (00:22:56) - What do you have on the horizon to bring innovation to the industry? Check out Uber for Business here - t.uber.com/CDGauto today  Check out the website for more (https://dealershipguy.com) and follow me on X @GuyDealership! (https://x.com/guydealership) This podcast is for informational purposes only and should not be relied upon as a basis for investment decisions.

06/12/2024, Keido Keith Baker, dharma talk at City Center. This talk was given by Keido Keith Baker at Beginner's Mind Temple, San Francisco. The Han's wooden knock calls countless practitioners to come to the Zendo for meditation. Indoors or outside, it's hard to miss its distinctive urgent rolldown. It's familiar hand-painted message encourages us all to not to waste time; that the life we have to understand birth and death, is short and passing quickly. Keido Keith shares some thoughts on the Great Matter of impermanence as seen from the view of the Han. Why is The Great Matter so urgent, and what are we being called to understand? Penetrating the surface of Birth and Death, we begin to find deeper meaning and a non-dualistic side by coming to understand impermanence, and interdependence.