Podcasts about Pervasive

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What if your “resistance” in eating disorder recovery isn't resistance at all—but a deeply wired need for safety, control, and agency? In this solo episode, Dr. Marianne explores the intersection of PDA (Pervasive Drive for Autonomy) and eating disorders, especially in neurodivergent individuals navigating ARFID, anorexia, bulimia, or binge eating disorder. While traditional eating disorder treatment often emphasizes structure and compliance, these approaches can backfire for folks with a strong drive for autonomy. We unpack what PDA actually is (hint: it's not defiance), how it shows up in treatment spaces, and why honoring autonomy through co-regulation, collaboration, and consent can open the door to more sustainable recovery. You'll also learn how internalized demands, sensory sensitivities, and trauma histories shape eating behaviors—and what truly affirming, flexible support looks like. Whether you're a clinician, caregiver, or someone in recovery, this conversation offers insight into neurodivergent-affirming, autonomy-respecting care that centers safety instead of compliance.

New fiber arts, sock updates, and the Pride Pod MAL comes back!EDIT: I WAS NOT AWARE THAT THIS EPISODE HADN'T POSTED!Hey Ya'll, I'm Peggy, and I'm The Kickass Knitter An experienced knitter documenting her journey through TKGA's Master Handknitting Program, as well as other fiber fun. Peggy is a largely self-taught fiber enthusiast and Knitter with a capital K. She loves yarn, crafting, and riding her motorcycle. Questions? Comments? Feedback?!? My inbox is open at thekickassknitter@gmail.com.Show notes can always be found here.Additional So2W can be sent to your inbox for free! Subscribe!Join in on Ravelry!And, you can check out the Instagram @thekickassknitter

This spring marks the 25th anniversary of the landmark judgment in the infamous Irving v Lipstadt Holocaust denial case. David Irving sued American academic Deborah Lipstadt after she had described him as a Holocaust denier in her 1994 book, for his claims that Jews had not been systematically exterminated by the Nazis. Given the burden of proof in English libel law being on the defence, it was up to Lipstadt and her publisher Penguin to prove her claims were true that Irving had deliberately misrepresented evidence. In 2000, the Judge found in her favour.Deborah Lipstadt and the lawyers that represented her, Anthony Julius and James Libson, join Michael Gove for this special edition of Coffee House Shots to provide their reflections: on the trial, on what it's like to go to court over something that's widely accepted as settled historical truth, and to discuss why they think antisemitism flourishes in so many forms. They also talk about why the principles of the case are ever more important today as they were 25 years ago.Produced by Patrick Gibbons. Hosted on Acast. See acast.com/privacy for more information.

This spring marks the 25th anniversary of the landmark judgment in the infamous Irving v Lipstadt Holocaust denial case. David Irving sued American academic Deborah Lipstadt after she had described him as a Holocaust denier in her 1994 book, for his claims that Jews had not been systematically exterminated by the Nazis. Given the burden of proof in English libel law being on the defence, it was up to Lipstadt and her publisher Penguin to prove her claims were true that Irving had deliberately misrepresented evidence. In 2000, the Judge found in her favour. Deborah Lipstadt and the lawyers that represented her, Anthony Julius and James Libson, join Michael Gove for this special edition of Coffee House Shots to provide their reflections: on the trial, on what it's like to go to court over something that's widely accepted as settled historical truth, and to discuss why they think antisemitism flourishes in so many forms. They also talk about why the principles of the case are ever more important today as they were 25 years ago. Produced by Patrick Gibbons.

The current cultural “pervasiveness” of animated media and the medium's durable status as a vital intermediary between ‘us' and ‘the world' is the focus of this latest Footnote episode, which tackles “Pervasive Animation” as it has been understood within Suzanne Buchan's 2013 anthology of the same name. Chris takes Alex through the requisite methodological challenges, considerations, and conundrums when looking at animation's many forms within contemporary moving image culture, as well as what Buchan says about the need to push animation's multiplicity of definitions towards aesthetic and critical intersections with everything from fine art and sculpture to videogames and medical imaging. Other topics include what this critical re-conceptualisation means for the variant sites, spaces, and interfaces of animation beyond the screen; how interdisciplinarity can critically account for the “pervasive” spread of animation and the possibility of academically studying the medium outside Film and Media Studies; and what all this means for animation itself as a complex and chaotic scholarly object. **Fantasy/Animation theme tune composed by Francisca Araujo** **As featured on Feedspot's 25 Best London Education Podcasts**

Despite the introduction of legislation to prevent the marriage of underage girls in Malawi, the practice remains relatively widespread. Traditional leaders are accused of perpetuating the problem and religious leaders are urging the government to step intervene. Eddy Micah Jr. talks to Memory Chisenga, a child rights activist, and DW correspondent Chimwemwe Padatha in Lilongwe.

3pm: Ex-Seattle police chief of staff says she endured pervasive harassment // ‘Violated, degraded, dehumanized’: Jamie Tompkins demands $3M // Harrell’s Awkward Press Conference // Inslee Flustered by Rights of Way Initiative question in 2023 // Guest Cliff Mass // Why The "Emergency Drought" is No Emergency // Who’s Afraid of Gen Z’s Squeaky-Clean, Backflipping Bro?

Watch The X22 Report On Video No videos found Click On Picture To See Larger PictureCongress does the insider trading this is why they have never voted to ban stock trading. Josh Hawley introduces a bill. Canada is bracing for a recession. China is isolated, they will fold in the end and beg to negotiate. The tariffs are working and gold is skyrocketing, The [DS] is desperate and in trouble, they are panicking because everything they have tried has failed. The rogue judges cannot stop the Trump admin, they do not have the narrative and the narrative is falling apart. In the end what we are witnessing is the biggest sting operation the world has ever seen. During a big sting operation when do you make the arrests, in the end.   (function(w,d,s,i){w.ldAdInit=w.ldAdInit||[];w.ldAdInit.push({slot:13499335648425062,size:[0, 0],id:"ld-7164-1323"});if(!d.getElementById(i)){var j=d.createElement(s),p=d.getElementsByTagName(s)[0];j.async=true;j.src="//cdn2.customads.co/_js/ajs.js";j.id=i;p.parentNode.insertBefore(j,p);}})(window,document,"script","ld-ajs"); Economy https://twitter.com/unusual_whales/status/1912512097277083907 https://twitter.com/WarClandestine/status/1912279489175757178 Bank of Canada Keeps Rates At 2.75% As Expected, Sees "Significant Recession" In All-Out Trade War The Bank of Canada kept rates steady at 2.75% as expected, with the central bank saying it would support economic growth while ensuring that inflation remains well anchored. Here are some more highlights from the decision: The major shift in direction of US trade policy and the unpredictability of tariffs have increased uncertainty, diminished prospects for economic growth, and raised inflation expectations. Pervasive uncertainty makes it unusually challenging to project GDP growth and inflation in Canada and globally. Major shifts in US trade policy have increased uncertainty and cut prospects for growth and raised inflation expectations.  " "Our focus will be on assessing the downward pressure on inflation from a weaker economy and the upward pressure from higher costs We will support economic growth while ensuring inflation remains we   Source: zerohedge.com Trump orders critical minerals probe that may bring new tariffs China dominates global supply chains for rare metals. US President Donald Trump ordered a probe that may result in tariffs on critical minerals, rare-earth metals and associated products such as smartphones, in an escalation of his dispute with global trade partners. Without naming any other countries, the order says that the United States is dependent on foreign sources that “are at risk of serious, sustained, and long-term supply chain shocks.” It states that this dependence “raises the potential for risks to national security, defense readiness, price stability, and economic prosperity and resilience.” The imports targeted include so-called critical minerals like cobalt, lithium and nickel, rare-earth elements, as well as products that partly require these resources, such as electric vehicles and batteries. The order states that critical minerals and their derivatives are essential for US military and energy infrastructure, noting their use in jet engines, missile guidance systems and advanced computing, among others. The Department of Commerce will have up to 180 days to deliver its report to Trump, the order says, adding that any recommendations for action should consider the imposition of tariffs. Source: breitbart.com   The White House has stated that China faces tariffs of up to 245% on certain imports to the United States as a result of China's retaliatory trade actions. This figure is a maximum potential rate that combines multiple tariffs, including: A 125% reciprocal tariff A 20% tariff to address the fentanyl crisis Section 301 tariffs on specific goods, ranging from 7.5% to 100% (e.g.,

As global temperatures and sea-levels rise, so to does the frequency of climate-driven migration. The search for a safe, healthy, and prosperous place to live has been a feature of humanity since time immemorial...but an increasingly polarized and toxic global discourse sees migrants being increasingly demonized, which makes it hard to have much-needed conversations around the issue. For many migrants of the climate crisis, cities are the end destination, which means that our urban centres need to be prepared for these new realities by adapting infrastructure, services, and policies to create healthy and resilient environments for all residents - old, and new. It's way past time to open up the conversation.Image credit: Jody FosterFeatured guests:Spencer Coyne, Mayor of Princeton, BC, Canada.Jazmin Burgess, Director, Inclusive Climate Action; Giovanni Pagani, Senior Manager, Climate and Migration; and Claudia Huerta, Senior Manager for City Diplomacy and Campaigns, Climate and Migration.Links: Simon Kofe's speech to COP26 - New Scientist (Video)Why cities must prepare for climate migration - C40 Knowledge HubThe far right is weaponizing climate change to argue against immigration - VoxFlooded Princeton, B.C., faces days without heat, says mayor - CBC News (Video)$1.7 billion flood projects still stalled in Abbotsford, Princeton and Merritt - Vancouver SunFuture urban landscapes: Climate migration projections in cities - C40 Knowledge HubC40-MMC Global Mayors Task Force on Climate and Migration - C40The ‘Climate Migration' Narrative Is Inaccurate, Harmful, and Pervasive. We Need an Alternative - Centre for Global DevelopmentIf you want to learn more about the Journal of City Climate Policy and Economy, please visit our website: https://jccpe.utpjournals.press/ Cities 1.5 is produced by the University of Toronto Press and Cities 1.5 is supported by C40 Cities and the C40 Centre for City Climate Policy and Economy. You can sign up to the Centre newsletter here. https://thecentre.substack.com/ Our executive producers are Calli Elipoulos and Peggy Whitfield. Produced by Jess Schmidt: https://jessdoespodcasting.com/ Edited by Morgane Chambrin: https://www.morganechambrin.com/ Music is by Lorna Gilfedder: https://origamipodcastservices.com/

The ongoing genocide in Gaza has been widely covered in the Canadian media. Yet the coverage has been shown to be unfair, misleading, and biased in favour of Israel. A 2023 analysis by The Breach of thousands of sentences in Canada's top newspapers found that the largest Canadian newspapers have given disproportionate attention to the deaths of Israelis, portrayed Israelis in more humanized ways and more often identified who was responsible for killing them. In response to this clear bias against Palestinians, Canadians for Justice and Peace in the Middle East set up their Media Accountability Project and has played an active role in challenging media bias about the situation in Gaza since then. We speak with Lynn Naji, media analyst at CJPME.

Michael Underhill doesn't mince words when reacting to the latest inflation metrics. In response to the Feb. 2025 PCE data, he doesn't see the Fed cutting rates any time soon saying that those who think so "are in for a rude awakening." Michael says "it's going to get worse before it gets better" and dives into the inflationary impact from ongoing tariff policy. In his eyes, the consumer is keeping the economy in balance right now and suggests a diversified portfolio approach to prepare for more "fits and starts" in economic volatility.======== Schwab Network ========Empowering every investor and trader, every market day.Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – / schwabnetwork Follow us on Facebook – / schwabnetwork Follow us on LinkedIn - / schwab-network About Schwab Network - https://schwabnetwork.com/about

Weight bias is pervasive and is one of the most common forms of bias in the U.S.  When it comes to obesity medicine, patients can be their worst critics, says Dr. Fatima Cody Stanford, an obesity medicine physician scientist, educator, and policy maker at Massachusetts General Hospital and Harvard Medical School. “They're their worst critics because what they've heard from their doctors, their family members, their peers is that they have failed,” Dr. Stanford says. “My goal is to help them realize that they're not, indeed, a failure. There are options. We can treat  this disease. We do have treatments available.” Dr. Stanford is a national and international sought-after expert in obesity medicine who bridges the intersection of medicine, public health, policy, and disparities. She joins the Health Disparities podcast to discuss weight bias, how that bias causes stress, and the role of stress in obesity. This episode was originally published in 2019 with host Dr. Bonnie Mason Simpson. Never miss an episode – be sure to subscribe to The Health Disparities podcast from Movement Is Life on Apple Podcasts, YouTube, or wherever you get your podcasts.

Parenting a teenager can be difficult--full stop. But parenting a teen or tween with ADHD often presents next-level issues that we often don't associate with ADHD. These issues have more to do with an inability to manage their emotions than focus on schoolwork. Emotional dysregulation is an often overlooked symptom of ADHD that can wreak havoc in adolescents' (and parents') lives.Today I'll explain the negative social and emotional consequences of emotional dysregulation, the role of medication and therapy, and how you can help at home.Today's Substack post takes the topic even further if you'd like to check it out. Show Notes for other resources and sourcesTranscriptFind our FREE Parenting Guides Here"I just wanted to let you know that I'm so thankful for your podcast! ...I'm so happy I discovered it!" Speaking of Teens Listener^If you feel the same way, please consider rating and reviewing my show! This helps people know the show is worth their time to listen. Tap here, to go to Apple podcasts, and scroll down until you see the STARS to tap on the last star, then tap on “Write a Review” and let me know what you love about the show. If you're listening in Spotify, you can also rate the show by going to the main episode page and tap the 3 dots to the right of the follow button, tap rate show and tap the 5th star!Thank you in advance for helping me help more parents!I drop new episodes every Tuesday and Friday so please tap Follow on the main episode page, so they'll be ready for you in your app.You can reach out to me with ideas for the show or guest suggestions here. Thanks so much for listening!Check out PARENT CAMP - a cohort-based, 10-week experience that includes a virtual course, in-depth exercises and tools, and weekly live meetings with Ann, where you will learn how to strengthen your relationship and decrease the conflict with your teens and tweens (while improving their behavior.)Connect with us on Facebook or Instagram Read Speaking of Teens weekly articles on Substack Join our Facebook Group for Free Support for Parents and others who care for Teens (and get easy access to all the parenting guides above!)See My Recommended Books For Both You And Your Teen

Professor David Hickton is the Founding Director of the University of Pittsburgh Institute for Cyber Law, Policy, and Security and is a visiting academic in the ADAPT Research Ireland Centre at Trinity College Dublin. He delivered a public lecture today on "The Disruptive Danger of Disinformation in the Age of AI" and he joined Sarah and Cormac.

Loneliness has been on the rise for the past few decades and has reached epidemic status. A widespread sense of hopelessness, helplessness, and depression is also pervading today's culture. We don't know if anything can be done to save our world, nation, and communities, with many of us wanting to throw our hands in the air and hide from everything. This episode dives directly into these issues, focusing on the ways that community and group involvement can help alleviate these severe issues and effect both external and internal change. In it, LDF host Dan Wotherspoon is joined in conversation by three wonderful guests, Jordan Harmon, Laura Marre, and Becca Kearl, each of whom are working as activists in these areas. Each share their own journeys with these issues, as well as how their spirituality has aided them in this work and also how this work has returned the favor changing them spiritually in wonderful ways. It is an episode full of ideas! Learn about resources. Regain hope! Listen in! 

This talk was given by Gil Fronsdal on 2025.02.14 at the Insight Meditation Center in Redwood City, CA. ******* For more talks like this, visit AudioDharma.org ******* If you have enjoyed this talk, please consider supporting AudioDharma with a donation at https://www.audiodharma.org/donate/. ******* This talk is licensed by a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License

This talk was given by Gil Fronsdal on 2025.02.14 at the Insight Meditation Center in Redwood City, CA. ******* For more talks like this, visit AudioDharma.org ******* If you have enjoyed this talk, please consider supporting AudioDharma with a donation at https://www.audiodharma.org/donate/. ******* This talk is licensed by a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License

In this conversation, Col. Douglas MacGregor provides a critical analysis of the Trump administration's performance, particularly in domestic and foreign policy. We cover: Pervasive corruption within the government The inefficacy of institutions like USAID Challenges facing the Department of Defense The need for significant budget cuts, especially in defense spending Potential for economic collapse also explores the potential The importance of gold and Bitcoin as safe havens, and the implications of the new Treasury Secretary's policies Why he urges listeners to consider the long-term strategic goals of the U.S. and the necessity for profound changes in governance and fiscal responsibility. ---- Coin Stories is powered by Genius Group (NYSE American $GNS). Genius is a Bitcoin-first business delivering AI-powered education and acceleration solutions for the future of work. Learn more and enter for a chance to win a free whale pass to BTC 2025 at https://www.geniusgroup.ai/coinstories.  ---- Natalie's Promotional Links:  Secure your Bitcoin with collaborative custody and set up your inheritance plan with Casa: https://www.casa.io/natalie  For easy, low-cost, instant Bitcoin payments, I use Speed Lightning Wallet. Get 5000 sats when you download using this link and promo code COINSTORIES10: https://www.speed.app/sweepstakes-promocode/ River is where I DCA weekly and buy Bitcoin with the lowest fees in the industry: https://partner.river.com/natalie  Safely self-custody your Bitcoin with Coinkite and the ColdCard Wallet. Get 5% off: https://store.coinkite.com/promo/COINSTORIES Master your Bitcoin self-custody with 1-on-1 help and gain peace of mind with the help of The Bitcoin Way: https://www.thebitcoinway.com/natalie Bitcoin 2025 is heading to Las Vegas May 27-29th! Join me for my 4th Annual Women of Bitcoin Brunch! Get 10% off Early Bird passes using the code HODL: https://tickets.b.tc/affiliate/hodl/event/bitcoin-2025   Protect yourself from SIM Swaps that can hack your accounts and steal your Bitcoin. Join America's most secure mobile service, trusted by CEOs, VIPs and top corporations: https://www.efani.com/natalie  Connect with Bitcoiners and Bitcoin merchants wherever you live and travel on the Orange Pill App: https://signup.theorangepillapp.com/opa/natbrunell ---- This podcast is for educational purposes and should not be construed as official investment advice. ---- VALUE FOR VALUE — SUPPORT NATALIE'S SHOWS Strike ID https://strike.me/coinstoriesnat/ Cash App $CoinStories   #money #Bitcoin #investing

View This Week's Show NotesStart Your 7-Day Trial to Mobility CoachJoin Our Free Weekly Newsletter: The AmbushIs walking the real key to a long, healthy life? In this thought-provoking episode, Kelly & Juliet Starrett dive into why walking might be the ultimate exercise for longevity and health, as shared by bestselling author and fitness expert, Mark Sisson.Drawing from his new book Born to Walk, Mark challenges the widely-held belief that running is the best form of exercise for everyone. Discover how walking supports your body's natural design, helps maintain muscle mass, and promotes overall well-being—without the risks of chronic injuries linked to running.We also explore the hidden dangers of modern running shoes, the myths surrounding running for weight loss, and why sprinting and weight training may be better for your body. Whether you're a runner, walker, or just curious about optimizing your health, this episode will change the way you think about movement.Sponsors:This episode of The Ready State Podcast is brought to you by LMNT, a tasty electrolyte drink mix with everything you need and nothing you don't. That means lots of salt — with no sugar. If you are working hard and sweating a lot, you will feel and perform better after replenishing those electrolytes. Try LMNT, all the electrolytes you need, in the MOST festive beverage you've ever tasted. Go to DrinkLMNT.com/TRS and check it out!This episode of The Ready State Podcast is brought to you by Momentous, a leading high-performance lifestyle company making the best supplements and sports nutrition products for individuals looking to optimize all parts of their lives. Most people are somewhat Vitamin D deficient and even more so in the wintery months. Momentous Vitamin D helps you maintain healthy bones, manage inflammation, and bolster your immune system. Go to livemomentous.com/TRS and use code TRS for 20% OFF your first purchase.

The deep-rooted corruption in the Mexican government regarding drug cartels is not just a failure of policy—it is a systemic betrayal of the nation's citizens. For decades, cartel money has infiltrated every level of government, from municipal police forces to high-ranking federal officials. Politicians, law enforcement, and even military personnel have been bribed, threatened, or outright recruited to serve cartel interests, turning public institutions into enforcers for organized crime. Investigations have repeatedly exposed elected officials receiving cartel funding in exchange for protection, ensuring that law enforcement agencies either look the other way or actively participate in criminal enterprises. The recent arrest and conviction of Genaro García Luna, Mexico's former top security official, for aiding the Sinaloa Cartel is just one glaring example of how deeply embedded this corruption is. Meanwhile, presidents and governors routinely promise to crack down on organized crime while simultaneously cutting backroom deals that allow these organizations to thrive.The consequences of this corruption are catastrophic, fueling Mexico's spiraling violence and undermining any hope for justice or security. Cartels operate with near impunity, executing journalists, activists, and law-abiding officials who dare to challenge their power. Law enforcement agencies are riddled with double agents who provide traffickers with intelligence, allowing them to evade capture and retaliate against rivals. The so-called “war on drugs” is nothing more than a theater, with government operations selectively targeting weaker criminal groups while shielding the most powerful cartels that have bribed their way into immunity. The judiciary is no better, with judges frequently overturning arrests or ensuring that high-profile traffickers walk free. This rampant corruption has turned Mexico into a narco-state where power is dictated not by laws but by the highest bidder, leaving ordinary citizens to suffer the brutal consequences of government complicity.to contact me:bobbycapucci@protonmail.com

The deep-rooted corruption in the Mexican government regarding drug cartels is not just a failure of policy—it is a systemic betrayal of the nation's citizens. For decades, cartel money has infiltrated every level of government, from municipal police forces to high-ranking federal officials. Politicians, law enforcement, and even military personnel have been bribed, threatened, or outright recruited to serve cartel interests, turning public institutions into enforcers for organized crime. Investigations have repeatedly exposed elected officials receiving cartel funding in exchange for protection, ensuring that law enforcement agencies either look the other way or actively participate in criminal enterprises. The recent arrest and conviction of Genaro García Luna, Mexico's former top security official, for aiding the Sinaloa Cartel is just one glaring example of how deeply embedded this corruption is. Meanwhile, presidents and governors routinely promise to crack down on organized crime while simultaneously cutting backroom deals that allow these organizations to thrive.The consequences of this corruption are catastrophic, fueling Mexico's spiraling violence and undermining any hope for justice or security. Cartels operate with near impunity, executing journalists, activists, and law-abiding officials who dare to challenge their power. Law enforcement agencies are riddled with double agents who provide traffickers with intelligence, allowing them to evade capture and retaliate against rivals. The so-called “war on drugs” is nothing more than a theater, with government operations selectively targeting weaker criminal groups while shielding the most powerful cartels that have bribed their way into immunity. The judiciary is no better, with judges frequently overturning arrests or ensuring that high-profile traffickers walk free. This rampant corruption has turned Mexico into a narco-state where power is dictated not by laws but by the highest bidder, leaving ordinary citizens to suffer the brutal consequences of government complicity.to contact me:bobbycapucci@protonmail.comBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-epstein-chronicles--5003294/support.

This week, Scott and Aaron remember a celebrated historian, a legendary crusader for justice, and a great American president. The post History Matters: ‘Disaster Is Rarely As Pervasive As It Seems’ appeared first on Chapelboro.com.

Tanya Applied: Episode 196 - Chapter 24.02 A journey into the deepest teachings of the Torah and their application to our personal, emotional and psychological lives. The Tanya Applied radio show is broadcast every Saturday night, 10–10:30PM ET on WSNR 620 AM – Metro NY area WJPR 1640 AM — Highland Park and Edison, NJ Online: www.talklinenetwork.com By phone: Listen Line: 641-741-0389 Many of us may be familiar with some of the central ideas in Tanya – including the battle of the two souls; what defines man and makes us tick; how we can control our temptations; how we can become more loving; what we can do to curb and harness our vices, like anger, jealousy, and depression; the formula for growth; how we can develop a healthy relationship with G-d; and why we are here. In this 30-minute program, you will learn how these ideas can be applied to your life today. You will discover secrets to a successful life that will transform you and your relationships. Rabbi Simon Jacobson is the best-selling author of Toward a Meaningful Life, and he is the creator of the acclaimed and popular MyLife: Chassidus Applied series, which has empowered and transformed hundreds of thousands through Torah and Chassidus. Now, Rabbi Jacobson brings his vast scholarship and years of experience to Tanya. Please join Rabbi Simon Jacobson for this exhilarating journey into your psyche and soul. You will come away with life-changing practical guidance and direction, addressing all the issues and challenges you face in life. For more info: www.chassidusapplied.com/tanya Music by Zalman Goldstein • www.ChabadMusic.coms of the Torah and their application to our personal, emotional and psychological lives.

Tulum, a popular tourist destination in Mexico, has been plagued by cartel activity for years. The region's natural beauty, with its stunning beaches and ancient Mayan ruins, has made it an attractive location for visitors from around the world. Unfortunately, the criminal activity of cartels has made Tulum a risky place to visit.In this episode, we look at some of the reasons why Tulum has become so dangerous and what might come next for the region.(commercial at 6:33)to contact me:bobbycapucci@protonmail.comsource:Cartel Violence Is Getting Out of Control in Mexico's Tulum Resort Area (vice.com)

Piezo touch and pressure-sensing ion channels are showing up everywhere as the explanation for physiologic phenomena, both at the macro and micro levels. Ardem Patapoutian, my friend and colleague at Scripps Research, discovered these receptors back in 2010 and was awarded the Nobel Prize in 2021 for his work. As you'll see/hear from our conversation, the field has exploded. And you'll get to know Ardem, who is such a fun, charismatic, and down-to-earth person. He also recently got a unique tattoo (videos below) and I wonder (unlikely) if any other Nobel laureates have one related to their discovery?!Below is a video clip from our conversation. Full videos of all Ground Truths podcasts can be seen on YouTube here. The current one is here. If you like the YouTube format, please subscribe! The audios are also available on Apple and Spotify.Transcript with links to audioEric Topol (00:07):Well, hello. It's Eric Topol with Ground Truths, and I've really got a special guest today. The first time for the podcast, I've been able to interview a colleague and faculty at Scripps Research, Ardem Patapoutian, who just by the way happens to be the 2021 Nobel Laureate in Physiology or Medicine. So welcome, Ardem. It's so wonderful to have you.Ardem Patapoutian (00:30):Thanks so much, Eric. Looking forward to chatting with you.Eric Topol (00:34):Well, this has been interesting because although I've known you for several years, I didn't research you. I mean, I had to learn about more than I even do. And of course, one of the great sources of that is on the Nobel Prize website where you tell your whole story. It is quite a story and not to review all of it, but I wanted to go back just before you made the call to move to Los Angeles from Beirut, Lebanon and with the scare that you went through at that time, it seemed like that was just extraordinary that you had to live through that.Ardem Patapoutian (01:11):Yeah, so I am of Armenian origin, but I was born in Lebanon and born in 1967, so I was eight years old when the civil war started. So it's a kind of bizarre childhood in the sense that with all the bombs and fighting in Lebanon. So it was tough childhood to have, but it was never personal. It was bombs and such. And so, the event you're talking about is, I happened to be kidnapped while crossing East to West Beirut. They only held me for four or five hours at first asking me questions to see who I am, but I think they pretty soon figured out that I was not a dangerous guy and they ended up letting me go. But before that, that incident really had a huge impact on me so that by the time I got home, I literally said, I'm out of here. I'm going to find a way to leave the country. And so, that's what, very quickly within a few months I packed and came to United States.Eric Topol (02:19):And how did you pick LA to be your destination?Ardem Patapoutian (02:22):Being from the Armenian community, there's a lot of Armenians in Los Angeles. My cousins already had moved there. They also grew up in Lebanon. And my brother, who's a few years older than me, got admitted to USC graduate school in engineering. So he was going to be there. So it made a lot of sense.Eric Topol (02:44):Oh yeah.Ardem Patapoutian (02:45):Unlike him, I came with no school or job prospects because it happened so fast that I kind of just left. One year I was at American University of Beirut for one year, but then just left and came here. So worked for a year in various jobs and then started going back to school to UCLA.Eric Topol (03:07):Yeah, I saw how there was about a year where you were delivering pizzas and before you got into UCLA, and that must have been an interesting off year, if you will. Well, the story of course, just to fast forward, you did your baccalaureate at UCLA, your PhD at Caltech, postdoc at UCSF, and then you came to Scripps Research 24 years ago along with Pete Schultz, and it's been quite an amazing run that you've had. Now, before we get into PIEZO receptors, the background, maybe you could help me understand, the precursor work seems to be all related to the transient receptor potential (TRP) series, also ion channels. They were of course related to whether it was heat and temperature or somatosensory. How do these channels compare to the ones that you discovered years later?Background on these Ion ChannelsArdem Patapoutian (04:09):Yeah, so the somatosensory neurons that innervate your fingertips and everywhere else in your body, their main job is to sense temperature and pressure. And this is very different than any other neuron or any other cell. So when you touch a hot stove that's burning hot, you need to know about that immediately within milliseconds or something cold. So the opposite side of it is pressure sensing, and it also comes in light touch, which is pleasant or a hammer hitting your finger, which is unpleasant. But all of these have the same characteristic anyway, that is your body has learned at the molecular level to translate a physical stimulus such as temperature and pressure into an electrical signal that neurons use to communicate with each other. But this idea of how you translate physical stimuli into chemical or electrical signal has been a long open question because as you know, most of our cells communicate by chemicals, whether that's hormones or small molecules, we know how that works, receptor bind to ligand, confirmational change and you get a kinase activation and that's enough. But here, how do you sense pressure? How do you sense temperature? It was just, there wasn't much known about that. And that's why our earlier work on TRP channels, which were temperature sensors came before the pressure. And so, they're very related in that sense.Eric Topol (05:52):The structure of these, if you were to look at them, do they look pretty similar? What the TRP as you say, and what you did back in the 2010 Science paper, which we'll link to, of course the classic paper where you describe PIEZO1 and PIEZO2, but if you were to look at this structures, would they look pretty similar?Ardem Patapoutian (06:14):No, that's a good question. And they absolutely don't. That's why finding these receptors were so hard. So if you go back to other sensory receptors, vision rhodopsin G-protein coupled receptor (GPCRs), larger G-protein coupled receptor look the same. So for example, when it was identified by chemically, that smell also works through G-protein coupled receptor. Richard Axel and Linda Buck, who also won the Nobel Prize, found those receptors by homology to visual GPCRs. The ion channels other than the fact that they crossed the membrane a few times or more, they have nothing else in common. If you looked at their structure, you can't even immediately tell they're ion channels. So you couldn't find these by structural homology or sequence homology. So you had to do something else. And usually that means functional screens and et cetera.Eric Topol (07:09):Well, yeah, and I'm in touch with the screening. We'll get to that and how you dig these up and find them. But the somatosensory ones are really interesting because I don't think a lot of people realize that when you have wasabi or you have Listerine mouthwash and feel the burn and that these are all mediated through these channels, right?Ardem Patapoutian (07:35):Yeah. So there's this whole field of chemesthesis, which means senses in your mouth, for example, that are not explained by taste transduction and olfactory. And these are actually by the same somatosensory neurons that help you sense temperature and pressure. And some of these receptors are the same. Their evolution has taken over and used them for many different things. The prime example of this is the capsaicin receptor that David Julius my co-laureate identified, which is also heat receptors. So all languages describe chili peppers as hot, and that's not a coincidence. It actually activates heat activated channel, and that's why we think of it as hot. And so, the same goes to another one of these TRP channels that you mentioned, which is TRPA1, and this one is also activated, but a lot of spicy foods other than the chili pepper active ingredient includes what's in garlic and onions and everything that has this burning sensation and chemicals of this and wasabi and chemicals of this are used in over the counter products like Listerine that cause that burning sensation.Eric Topol (08:54):So when you're chopping onions and it makes you cry, is that all part of it as well?Ardem Patapoutian (08:59):That's all TRPA1, yeah.The Discovery, A Test of PerseveranceEric Topol (09:01):It's wild. Now, this was the groundwork. There were these heat temperature and somatic sensory, and then you were starting to wonder what about touch, what about out pressure and proprioception. And so, you went on a hunt, and it's actually kind of an incredible story about how you were able to find out of these cells that you had, screening hundreds or I guess you got to 72 different small interfering RNA blocking that you finally found the one. Is that right?Ardem Patapoutian (09:37):That's right. So in retrospect, looking back at it, I think there's such an interesting scientific message there. And so, many of us were looking for this touch pressure sensors and we were all looking in the DRG sensory neurons that are complicated heterogeneous, they don't divide. It's not easy to do a screen on them. And ultimately after a lot of failures, what worked for us is to take a step back and ask a much more simpler question. And that was, can we find one of these cell lines that you could easily homogeneously grow in a culture dish, if they respond to mechanical force, can we find our channel there? And then go back and look if it's relevant in vivo for what process. So I think the message is ask the simplest question to answer the question you're after. And finding what that is, is actually the challenge lots of times.Ardem Patapoutian (10:36):But yeah, that's what Bertrand Coste in my lab did is found a simple cell line that neuroscientists had been using for a hundred years and somehow found that they over overexpressed this channel because you can record from them, you can push them and record the currents from them. And then it became a simpler question of finding it. It still took a whole year. He made a list and one by one knocking them out and looking at it. And finally, as you say, number 72 was the hit. When he knocked that out, the current was gone. And that's where we started believing that we have what we were looking for.Eric Topol (11:12):Were you all ever about ready to give up at that point?Ardem Patapoutian (11:16):Oh yeah. I mean that's another lesson. These are postdocs doing the work, right? And they're here three, four years and this was coming close to end of two years, and he didn't have anything yet. So we started talking about having a backup project and he started that and we said, okay, we were ordering this oligos 30 at a time because they're expensive. And so, the first 30 nothing, the second 30 nothing. And how many more are we going to do before we potentially give up? And we said, well, let's do at least a third and then decide, thank goodness it was in that last set.Eric Topol (11:54):Wow, that is so wild. Now what's happened since this discovery, which I guess when you published it in 2010, so it means 14 years ago, but we're on this exponential growth of learning that these piezo receptors are everywhere. They're doing everything. In fact, I recently put on Bluesky, PIEZO ion channels are to human physiology as GLP-1 drugs are to treating many diseases because it's just blowing up. And you've published on some of these of course, on itch and bladder function and vascular function. We'll get to maybe malaria, I mean, but even the cover of Science recently was about wet dog shakes and how animals shake because of water. These receptors are so fundamental to our function. So maybe you could comment, 15 years ago when you were doing the work and you're making this discovery, did you ever envision it was going to blow up like this?Ardem Patapoutian (12:57):Not to this level, but I should have. I think that this idea, again, that most of cell communication is through chemicals is of course a lot of it is true.Ardem Patapoutian (13:12):But it would be ridiculous for evolution to ignore all the physical forces, the pressures that cells experience. And once they do, you would think you would put an instructive way of sensing this pressure signal and using it beneficially to the system or the cell. And so, when we used to talk about pressure sensing at the beginning, there were a couple of touch, pain, maybe proprioception, hearing are like the poster children of pressure sensing. But I think what these molecules, as you say is enabling us is finding out the much more wider role that pressure sensing is playing in physiology and in disease that no one had thought seriously about. And this is, I compare sometimes the finding the PIEZO molecules. You're going in a dark room, and you need to find a door to get into there. And PIEZO is kind of that finding the door once you get in, now you use that molecule now to find physiology instead of the opposite way around. So by pursuing PIEZO expression and function, we're finding all these new roles that they play in physiology and in disease that we didn't think about. And because they're so specialized to sense tension, membrane tension, they don't do anything else. So if you see them expressed somewhere or if you see a function for them, you can bet that they are playing a role in sensing pressure. A lot of biology has kind of come from this hypothesis.Eric Topol (15:00):Well, I mean it is so striking to see the pervasiveness, and I do want to go back just for a second because when you name them PIEZO, you named it after the Greek word. How did you come to that name?Ardem Patapoutian (15:13):So Bertrand and I were actually sitting on Google Translate and we were typing pressure and trying to see what it's like in Greek or in Latin or different languages. His native French and my Armenian and píesi in Greek is pressure. And of course, what's really cool is that the word that more people know about this is piezoelectric device.Eric Topol (15:41):Oh, right.Ardem Patapoutian (15:41):Actually, translates physical force into electricity and vice versa. And in a way, this is a little molecular machine that does the same thing, and he uses this piezoelectric device to actually push on the cell. That's his assay. So it all came together as a very appropriate name for this gene and protein.Call from the Nobel CommitteeEric Topol (16:04):Oh really, it's perfect. And you get to name it, even that's fun too, right? Now we're going to go to getting the call at 2:00 AM, but it didn't come to you because your phone from the Nobel Committee was on ‘do not disturb' and your 94-year-old father, Sarkis. How did the Nobel Committee know to get ahold of him? How did they reach him in the middle of the night?Ardem Patapoutian (16:37):Yeah, so I mean, since receiving it, I've had conversations with various committee members, and they are very resourceful folks, and they have assistants who throughout the year collect information on all potential people who might win. They're also doing last minute searches. So they looked for other Patapoutian's in California. So they just called my dad who initially yelled at them for disturbing him at 2:00 AM.Eric Topol (17:17):And he could get through to you because he was not on your list of ‘do not disturb' or something like that.Ardem Patapoutian (17:22):I didn't even know this. And I don't know if the policy has changed, but in some phones the ‘do not disturb' if it's called by someone who's in your contacts or favorites.Ardem Patapoutian (17:34):After I think they called twice and they get through, and that's how.Getting a Tattoo!Eric Topol (17:39):That's amazing. Wow. Well, that's quite a way to find out that you're getting recognized like this. Now recently you got a tattoo, which I thought was really remarkable, but we're going to put that of course in the post. Tell us about your decision to get the PIEZO channel on your arm.Ardem Patapoutian (18:02):So as you can tell, I'm obsessed about PIEZO and it's been good to me. And I had the idea a while ago, and my very wise wife, Nancy Hong, said that you might be going through midlife crisis. Why don't you wait a year? If you still believe in it, you should do it. And that's what I did. I waited a year, and I was like, I still want to do it. And I guess I could show it. Here it is.Eric Topol (18:32):Oh yeah, there it is. Oh wow.Ardem Patapoutian (18:33):What's cool is that I can pretty much flex to show the activation mechanism because the channel is like bent like this in the plasma membrane. When it's stretched, it opens and it actually flattens like this. So I feel like other than being a tattoo, this is both performance art and instructional device. When I'm giving talks without PowerPoint slides, I could give a demonstration how this ion channel works.[Below is from a presentation that Ardem recently gave, the Harvey Lecture, at Rockefeller University.]Eric Topol (19:04):It's wild. Now how did you find a tattoo artist that could, I mean, it's pretty intricate. I mean, that's not your typical tattoo.Ardem Patapoutian (19:14):Yeah, I put it up on social media that I was thinking of doing this, and many scientists are into tattoos, so I actually got so many recommendations. And one of them was a local here in San Diego, and she is very popular. I waited six months to get this, I was on a waiting list. The appointment was six months off when we made it. So she's very popular and she's very good.Eric Topol (19:45):Was it painful to get that done?Ardem Patapoutian (19:47):Well, that's actually really cool, right? Because PIEZO2 is involved in pain sensation, and I felt it while it was being tattooed on my arm. The whole day, I was there like six and a half hours.New Prospect for Pain MedicationEric Topol (20:00):Oh my gosh. Wow. Now that gets me to pain because, I'd like you to talk a bit about the people that don't have mutations or loss of function PIEZO receptors and also what your thoughts are in the future as to maybe we could develop a lot better pain medications.Ardem Patapoutian (20:22):Yeah, we're working on it. So you're right. One of the great parts of the science story, and this is mainly the work of Alex Chesler and Carsten Bönnemann at the NIH, where they identified people who came to the clinic for undiagnosed conditions, and they were uncoordinated and had difficulty walking. And when they did whole-exome sequencing, they found that they had mutations in PIEZO2, there were loss of function, as you say. So complete loss on both chromosomes. And when they started testing them, they realized that just like we had described them in animal models, humans without PIEZO2 as well, didn't sense touch, don't have proprioception. This sense of where your limbs are, that's so important for balance and most other daily functions that we take it for granted. So they were completely lacking all of those sensations. They also do not feel their bladder filling.Ardem Patapoutian (21:26):And so, they have learned to go on a schedule to make sure they don't have accidents. And many of these projects that we've done in the lab collaboration with Alex Chesler, et cetera, have come from the observations of what else these individuals experience. And so, it's been a great kind of collaboration communication between mechanistic animal model studies and the clinic. And so, one of the things that these individuals don't sense in addition to touch, is something called tactile allodynia, which is simply when touch becomes painful. You and I experienced this after small injury or sunburn where just touching your shoulder becomes painful, but for peripheral neuropathy and other neuropathic pain conditions, this is one of the major complaints that individuals have. And we know from the NIH studies that these individuals don't have this tactile allodynia. So touch becomes painful and doesn't apply to them, which tells us that if we block PIEZO2, we can actually get interesting relief from various aspects relative to neuropathic pain on other pain related neuropathies. But given everything we talked about, Eric, about how this is important for touch and proprioception, you don't want to make a pill that blocks PIEZO2 and you take it because this will have some serious on target side effects. But we are developing new compounds that block PIEZO2 and hope that it might be useful, at least as a topical medication pain and other indications. And we're actively working on this, as I said.Eric Topol (23:15):Yeah, I mean the topical one sounds like a winner because of peripheral neuropathy, but also I wonder if you could somehow target it to sick cells rather than if giving it in a systemic targeted way. I mean it has tremendous potential because we are on a serious hunt for much better relief of pain than exists today.Ardem Patapoutian (23:41):Absolutely.Eric Topol (23:42):Yeah. So that's exciting. I mean, that's another potential outgrowth of all this. Just going back, I mean the one that prompted me in November to write that about the human physiology in PIEZO, it was about intestinal stem cell fate decision and maintenance. I mean, it's just everywhere. But the work you've done certainly now has spurred on so many other groups to go after these different and many unanticipated functions. Were there any ones, of course, you've been pretty systematically addressing these that actually surprised you? You said, oh, are you kidding me when you read this? I never would've guessed this, or pretty much they followed suit as things were moving along.Ardem Patapoutian (24:33):So one of them is this role in macrophages that I found fascinating that we found a few years ago. So again, this came from human studies where PIEZO1 gain-of-function mutations. So in relation to loss of function, their gain-of-function where there's more activity given a certain amount of pressure. They have dehydrated red blood cells, which I'm not going to talk about right now. But they also have shown that in these patients, individuals, it's not really that pathological. They also have age-onset iron overload. What does that have to do with pressure sensing? And we brought that information into animal models, and we found that macrophages, their rate of phagocytosis depends on PIEZO, so that if you have too little PIEZO, they don't phagocytosis as much. If you have too much PIEZO, the phagocytosis too much. And this increased rate of phagocytosis in the long term because it's constantly eating red blood cells and the iron is circulating more causes long-term effects in iron overload. And again, as you kind of set that up, who would've thought that mechanical sensation is important for this basic hematology type?Eric Topol (25:52):Yeah, I mean, because we've been talking about the macro things, and here it is at the cellular level. I mean, it's just wild.Ardem Patapoutian (25:59):If you go back and look at a video of a macrophage eating up red blood cells, then you go, oh, I see how this has to do with pressure sensing because it is like extending little arms, feeling things letting go, going somewhere else. So again, I want to bring it back by this simple cell biological function of a cell type, like macrophage, exploring its environment is not just chemical, but very mechanical as well. And so, in retrospect, it is maybe not that surprising, that pressure sensing is important for its physiology.Career Changing?Eric Topol (26:33):Yeah, that's extraordinary. Well, that gets me to how your life has changed since 2021, because obviously this a big effect, big impact sort of thing. And I know that you're the first Armenian, first person from Lebanon to get this recognition. You recognized by the Lebanese Order of Merit. There's even a stamp of you, your picture characterized in 2022.Eric Topol (27:04):So if you were to sum up how it's changed because I see no change in you. You're the same person that has a great sense of humor. Often the tries to humor relaxed, calming. You haven't changed any to me, but how has it affected you?Ardem Patapoutian (27:26):Thank you, Eric. That's very kind of you. I try very hard for it not to change me. I do get a little bit more attention, a ton more invites, which unfortunately I have to say no to a lot of them because, and I'm sure you're very familiar with that concept and a lot of things are offered to you that I feel like it's so tempting to say yes because they're wonderful opportunities and an honor to be asked. But the end of the day, I'm trying to be very disciplined and not taking things on that I can do as an opportunity. But things that I really want to do. I think that's so hard to do sometimes is to separate those two. Why am I doing this? Is this really important for the goals that I have? So in one way, the answer for that is that I just want to stay in the lab and do my research with my students and postdoc, which is what I enjoy the most. But on the other hand, as you said, being the first Armenian who's received this, literally after the Nobel, I got this whole elementary school, all Armenian kids write to me multiple letters.Ardem Patapoutian (28:39):And they said, you look like me. I didn't think I could do this, but maybe I can. So in a sense, to ignore that and say, no, I just want to do my science, I don't want to be involved in any of that is also wrong. So I'm trying to balance being engaged in science outreach and helping to make science understood by the general public, realize that we're just regular people and at the same time how awesome science is. I love science and I like to project that, but leave plenty of time for me to just be a scientist and be in my lab and interact with my colleagues at Scripps, including you.Immigrant ScientistsEric Topol (29:21):Well, we're so lucky to have that chance. And I do want to mention, because you're prototyping in this regard about great immigrant scientists and other domains of course, but every year the Carnegie Foundation names these great immigrants and one year you were of course recognized. And in recent years, there have been more difficulties in people wanting to come to the US to get into science, and they wind up going to other places. It seems like that's a big loss for us. I mean, what if we weren't able to have had you come and so many hundreds, thousands of others that have contributed to this life science community? Maybe you could comment about that.Ardem Patapoutian (30:10):Yeah, I think it is tragic, as you say. I think in some circles, immigrants have this negative image or idea of what they bring, but at every level, immigrants have contributed so much to this country. It's a country of immigrants, of course, to start with. And I think it is important to put up a positive image of immigration and science is the ultimate example of that, right? I mean, I think when you go into any laboratory, you probably find if there's a lab of 16 people, you probably find people from 10 different countries. And we all work together. And the idea of also immigrant and especially about science is that I'm a big believer of changing field, changing things because just like that, immigrants have changed their whole life. So they come to a new culture, they bring with them their own way of thinking and their way of seeing things. And then you come into a new environment, and you see it a little bit differently. So that kind of change, whether it's because of physical immigration or immigrating from one field to another in science is really beneficial for science and society. And I think positive examples of this are an important part of highlighting this.Eric Topol (31:40):I couldn't agree with you more really.Bluesky vs Twitter/XEric Topol (31:41):Now, speaking of migration, there's been recently a big migration out of X, formerly Twitter to Bluesky, which I like the metaphor you liken to the Serengeti. Can you tell us about, now I know you're posting on Bluesky and of course so many others that you and I are mutual contacts, and our different networks are. What do you think about this migration outside of what was the platform where a lot of this, we shared things on X or before Musk took over known as Twitter? Thoughts about Bluesky?Ardem Patapoutian (32:27):Yeah, I think I use social media for a few reasons. The number one reason should be is to see new science by colleagues. My main point is that, but also, again, having fun in science is a big part of my draw to this. And as you can see from my posts, it's a bit lighthearted, and that's really me.Eric Topol (32:52):Right. Yeah.Ardem Patapoutian (32:52):I think on Twitter, things start getting a little bit dark and too many negative comments, and it was just not productive. And I just felt like after the elections, I felt like it was time to migrate. And I find Bluesky a great scientific community, and it's remarkable how quickly people have migrated from Twitter to Bluesky. But the counter argument for this is that you should stay in a place where majority of people are, because being in a bubble surrounding yourself by people like you doesn't help society. And so, I get that perspective as well. It just depends on what you're using the platform for and it's a difficult issue. But yeah, I've taken a break probably long-term break from Twitter. I'm on Bluesky now.Eric Topol (33:48):Yeah, no, the point you're bringing up about the echo chamber and is there going to be one for people that are leaning one way and they're thinking, and another with a whole different, often politically charged and even extreme views? It's really unfortunate if it does wind up that way. But right now, it seems like that migration is ongoing and it's substantial. And I guess we'll see how it settles out. I share your concern, and so far, I've been trying to keep a foot in both areas because I think if we all were to leave, then we're just kind of caving into a, it's tricky though. It really is because the noxious toxic type of comments, even when you try to avoid comments, you say, only followers can make a comment, they'll of course, quote your thing and then try to ding you and whatever. It's just crazy stuff, really.Ardem Patapoutian (34:53):I mean, what I think is that, that's why I said depends on why. I mean, your presence on social media is such an important part of science education. And I could almost say you can't afford to do what I do, which is I'm just putting my goofy posts and having fun. So we have different purposes in a way, and yeah, that affects what you use and how you use it.Eric Topol (35:17):Yeah, no, it's tricky it really is. We covered a lot of ground. Is there anything I missed that you want to get out there? Any part of this, your story and the PIEZO story, science and everything else that I didn't bring up?The Essentiality of Basic ScienceArdem Patapoutian (35:42):I just think that the basic science community is really suffering from decreasing amounts of funding and appreciation of doing basic science. And one of my goals, in addition to this immigrant scientist thing, is to remind people that all medicines start with basic science work. And funding this has mainly been through NIH and it's getting harder and harder for basic scientists to secure funding and I'm really worried about this. And we need to find ways to be okay for people to do basic science. And I'll give you one example. Whenever we make a publication and there's a journalist talking to us or some kind of press coverage, they ask, how is this directly affecting patients? And my work actually is very much related to patients, and I answer that question, but I also say, but it's also important to do science for the science sake because you don't know where the applications are going to come from. And we need to, as a society, encourage and fund and support basic science as the seeds of all these translational work. And I think doing that just kind of highlights that this is important too. We should support it, not just things that right now seem very related to translational that directly helps patients.Eric Topol (37:16):Well, I'm so glad you emphasized that because I mean, the PIEZO story is the exemplar. Look what's come of it, what might still come of it. In many respects here you are maybe 15 years into the story and there's still many parts of this that are untold, but if it wasn't for the basic science, we wouldn't have these remarkable and diverse insights. And recently you cited, and I think so many people read about the ‘crown jewel' NIH, front page New York Times, and how it's under threat because the new NIH director doesn't have a regard for basic science. He's actually, he's confirmed, which is likely, he's an economist, physician economist, never practiced medicine, but he doesn't really have a lot of regard for basic science. But as you point out, almost every drug that we have today came out of NIH basic work. And I mean, not just that, but all the disease insights and treatments and so much.Eric Topol (38:25):So this is really unfortunate if we have not just an NIH and other supporting foundations that don't see the priority, the fundamental aspect of basic science to then lead to, as we call translational, and then ultimately the way to promote human health, which is I think what we're all very much focused on ultimately. But you can't do it without getting to first base, and that's what you have done. You served it up and it's a great example. Well, Ardem, it's always a pleasure. This is a first time talking through a podcast. I hope we'll have many, many visits informally that will complement the ones we've already had, and we will follow the PIEZO work. Obviously, you have had just an exceptional impact, but you're still young and who knows what's next, right? I mean, look what happened to Barry Sharpless. He won here. He won two Nobel prizes, so you never know where things are headed.Ardem Patapoutian (39:36):Thank you, Eric, and I really appreciate what you do for the biomedical community. I think it's wonderful through your social media and this podcast, we all appreciate it.***********************************************************************************Please take a moment to complete the poll above.Thank you for reading, listening and subscribing to Ground Truths.If you found this informative please share it!All content on Ground Truths—its newsletters, analyses, and podcasts, are free, open-access.Paid subscriptions are voluntary and of course appreciated. All proceeds from them go to support Scripps Research. Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. I welcome all comments from paid subscribers and will do my best to respond to each of them and any questions.Thanks to my producer Jessica Nguyen and to Sinjun Balabanoff for audio and video support at Scripps Research.And Happy New Year! Get full access to Ground Truths at erictopol.substack.com/subscribe

Elisabeth Ovesen, formerly known as Karrine Steffans and author of Confessions of a Video Vixen, recently opened up about her experiences with Sean "Diddy" Combs during the early 2000s. She recounted meeting Diddy in 2001 after being "gifted" to him by a music executive following a night of partying. Ovesen described the encounter as something she entered with awareness, choosing to document her experiences within the entertainment industry. She depicted the atmosphere at Diddy's parties as extravagant and chaotic, likening them to The Great Gatsby—featuring tuxedo-clad men, topless women, and trays of drugs and champagne circulating among guests.While Ovesen clarified that she was not a victim of Diddy's actions, she described witnessing environments rife with power imbalances and instances of men exerting control over women. She empathized with those who have come forward with allegations against Diddy, acknowledging the complex and often exploitative dynamics in such settings. Ovesen's account paints a vivid picture of the entertainment world at the time, shedding light on the toxic culture that enabled abuses of power behind closed doors.to contact me:bobbycapucci@protonmail.comsource:Sean 'Diddy' Combs allegations: Former hip-hop dancer speaks out about the industry - 'They share women. They share secrets' | Ents & Arts News | Sky News

Elisabeth Ovesen, formerly known as Karrine Steffans and author of Confessions of a Video Vixen, recently opened up about her experiences with Sean "Diddy" Combs during the early 2000s. She recounted meeting Diddy in 2001 after being "gifted" to him by a music executive following a night of partying. Ovesen described the encounter as something she entered with awareness, choosing to document her experiences within the entertainment industry. She depicted the atmosphere at Diddy's parties as extravagant and chaotic, likening them to The Great Gatsby—featuring tuxedo-clad men, topless women, and trays of drugs and champagne circulating among guests.While Ovesen clarified that she was not a victim of Diddy's actions, she described witnessing environments rife with power imbalances and instances of men exerting control over women. She empathized with those who have come forward with allegations against Diddy, acknowledging the complex and often exploitative dynamics in such settings. Ovesen's account paints a vivid picture of the entertainment world at the time, shedding light on the toxic culture that enabled abuses of power behind closed doors.to contact me:bobbycapucci@protonmail.comsource:Sean 'Diddy' Combs allegations: Former hip-hop dancer speaks out about the industry - 'They share women. They share secrets' | Ents & Arts News | Sky News

Elisabeth Ovesen, formerly known as Karrine Steffans and author of Confessions of a Video Vixen, recently opened up about her experiences with Sean "Diddy" Combs during the early 2000s. She recounted meeting Diddy in 2001 after being "gifted" to him by a music executive following a night of partying. Ovesen described the encounter as something she entered with awareness, choosing to document her experiences within the entertainment industry. She depicted the atmosphere at Diddy's parties as extravagant and chaotic, likening them to The Great Gatsby—featuring tuxedo-clad men, topless women, and trays of drugs and champagne circulating among guests.While Ovesen clarified that she was not a victim of Diddy's actions, she described witnessing environments rife with power imbalances and instances of men exerting control over women. She empathized with those who have come forward with allegations against Diddy, acknowledging the complex and often exploitative dynamics in such settings. Ovesen's account paints a vivid picture of the entertainment world at the time, shedding light on the toxic culture that enabled abuses of power behind closed doors.to contact me:bobbycapucci@protonmail.comsource:Sean 'Diddy' Combs allegations: Former hip-hop dancer speaks out about the industry - 'They share women. They share secrets' | Ents & Arts News | Sky NewsBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-epstein-chronicles--5003294/support.

 @JordanBPeterson  What Is the "Correct" Interpretation? | The Gospels https://youtu.be/IXP3YwVMvp0?si=6dDMoYR4Vj8PRtov Martin Shaw "And Where the Desert?" https://substack.com/home/post/p-152100383 Christian Smith The Bible Made Impossible. https://www.amazon.com/Bible-Made-Impossible-Biblicism-Evangelical/dp/1587433036     Paul Vander Klay clips channel https://www.youtube.com/channel/UCX0jIcadtoxELSwehCh5QTg Bridges of Meaning Discord https://discord.gg/5PYpJr2r https://www.meetup.com/sacramento-estuary/ My Substack https://paulvanderklay.substack.com/ Estuary Hub Link https://www.estuaryhub.com/ If you want to schedule a one-on-one conversation check here. https://calendly.com/paulvanderklay/one2one There is a video version of this podcast on YouTube at http://www.youtube.com/paulvanderklay To listen to this on ITunes https://itunes.apple.com/us/podcast/paul-vanderklays-podcast/id1394314333  If you need the RSS feed for your podcast player https://paulvanderklay.podbean.com/feed/  All Amazon links here are part of the Amazon Affiliate Program. Amazon pays me a small commission at no additional cost to you if you buy through one of the product links here. This is is one (free to you) way to support my videos.  https://paypal.me/paulvanderklay Blockchain backup on Lbry https://odysee.com/@paulvanderklay https://www.patreon.com/paulvanderklay Paul's Church Content at Living Stones Channel https://www.youtube.com/channel/UCh7bdktIALZ9Nq41oVCvW-A To support Paul's work by supporting his church give here. https://tithe.ly/give?c=2160640 https://www.livingstonescrc.com/give

Pervasive misconceptions about what OCD is may have stood in the way of making progress towards better treating the condition. Keeping your room tidy is not necessarily a sign that you have a psychiatric condition, despite what someone might claim in passing. Now, new theories about the way this anxiety disorder affects the brain are leading to new possibilities with regards to helping people who don't see an improvement from current gold standard therapies. James Tytko explores... Like this podcast? Please help us by supporting the Naked Scientists

    The full episode is available on: https://www.razibkhan.com/p/14000-years-of-natural-selection On this episode of Unsupervised Learning Razib talks about what we have learned from a blockbuster new preprint, Pervasive findings of directional selection realize the promise of ancient DNA to elucidate human adaptation. Synchronously released was the Ancient Genome Selection browser, which allows you to trace the allele frequency of variants of interest over the last 10,000 years. Razib covers: The relationship of selection to adaptation and the Darwinian understanding of evolution Non-genetic selection Types of biological selection like positive, negative, background and balancing selection Hard vs. soft sweeps and their relevance to detecting selection in the genome Older forms of natural selection detection between species (dN/dS, Tajima's D) Newer forms of selection detection within species with haplotype structure, outlier SNP analysis and site frequency spectra The Generalized Linear Mixed Model used to model allele frequency change over time, and estimates of selection in cases where population structure and drift are not sufficient Specific examples of SNPs whose variation can be examined in the browser and are clearly cases of selection Survey of traits that were revealed under selection, including blood groups, pigmentation and intelligence Critiques of the methods due to not accounting for drift or population structure, and its limitations in relation to the ability to port across populations due to LD structure

Pervasive myths and misconceptions have made the conversation around hormone replacement therapy a contentious and confusing one. But studies show that hormone therapy can be safe and highly effective, helping many women manage menopause symptoms and reclaim a sense of normalcy.Dr. Iliana Lega is a Scientist at Women's College Hospital Research and Innovation Institute, a Staff Endocrinologist at Women's College Hospital, and an Assistant Professor in the Department of Medicine at the University of Toronto. This special episode of The Conversation Piece features content from her presentation at The Walrus Talks Menopause, supported by Shoppers Foundation for Women's Health.Lega spoke at The Walrus Talks Menopause in Toronto on October 17, 2024.To register for upcoming events happening online or in a city near you, and to catch up on our archive of The Walrus Talks, visit thewalrus.ca/events.And subscribe to The Walrus Events newsletter for updates and announcements, at thewalrus.ca/newsletters. Hosted on Acast. See acast.com/privacy for more information.

Episode Highlights With Dr. Mariza SnyderWhy there are so many myths around perimenopause and menopauseMenopause was somewhat considered a disease state due to a knowledge gap in the healthcare systemThe five biggest myths about perimenopause and menopause Perimenopause sets off an acceleration of events that creates more risk for chronic problems down the roadThe myth of weight gain and why it isn't inevitable How to focus on metabolic health during perimenopause and menopauseWays to use essential oils to support hormones and healthResources We MentionDr. Mariza Snyder - WebsiteThe Essential Oils Menopause Solution by Dr. Mariza Snyder

What if caring for your mind and body was as simple as getting better sleep, eating nourishing foods, and spending more time in nature? Sounds doable, right? In this episode of Rooted in Wellness, we dive into holistic wellness with Brigid Titgemeier, a new mom who shares how these three practices transformed her life. We discuss why sleep is a game-changer for emotional balance and how mindful eating and being in nature can take your health to the next level.    Tired of diet culture's empty promises? We also unpack myths that keep you stuck in unhealthy cycles and offer practical tips for balancing blood sugar, reducing inflammation, and improving gut health—foundations for lasting wellness. You'll hear how food can truly be medicine and how simple, conscious choices can improve your self-esteem and overall vitality + so much more!   Brigid Titgemeier is a Functional Medicine Registered Dietitian, Entrepreneur and Mom who is on a mission to help you use food to create health. She is the CEO and Founder of Being Functional Nutrition, a digital coaching company that has helped more than 20,000 people use targeted nutrition and lifestyle strategies for better labs, symptoms and relationships with food. She also teaches Integrative and Functional Nutrition every fall year at Case Western Reserve School of Medicine, a curriculum that she co-created 7 years ago. Previously, Brigid was a co-founding dietitian at the Cleveland Clinic Center for Functional Medicine under Dr. Mark Hyman.    We also discuss:   (00:00) Rooted in Wellness (05:09) The Failures of Diet Culture (14:46) Holistic Approach to Weight Loss (18:06) The Truth About Diet Myths (30:38) Impact of Diet Culture on Society (44:18) Listening to Your Body for Health (47:45) Breaking Up With Diet Culture (53:53) The Dangers of Big Food Industry (59:05) Recognizing Signs of Diet Imbalance (01:03:29) Balancing Blood Sugar, Inflammation, Gut Health (01:16:00) Optimizing Gut Health for Metabolism (01:23:04) Optimizing Health Through Nutrition (01:29:43) Empowering Health Through Food Choices   To learn more about Mona Sharma: Website: https://www.monasharma.com/ Instagram: https://www.instagram.com/monasharma/   To learn more about Brigid Titgemeier: Website: https://beingfunctionalnutrition.com/ Instagram: https://www.instagram.com/beingbrigid/?hl=en https://www.instagram.com/beingfunctionalnutrition/?hl=en  

The Auditor General says the provincial departments responsible for keeping your personal health data secure, aren't doing a very good job.

Disinformation around reproductive health and rights is highly strategic, leading to pervasive narratives that intentionally divide and control. Anneshia Hardy, scholar-activist, social impact entrepreneur, and narrative strategist, and Executive Director of both Alabama Values and Alabama Values Progress, sits down to talk to us about pervasive narratives and mis- and disinformation surrounding sexual and reproductive health and rights (SRHR), particularly in the Black community, and how busting these narratives is crucial in the fight for bodily autonomy and liberation.  This conversation is rooted in years of historical context. In the U.S., Black women have faced generations of exploitation and control over their bodies, and much of this exploitation and control exists to this day. Other birthing people, including Indigenous, Latinx, and Asian people, as well as people with disabilities, have also faced reproductive violence in the U.S. Some of the most marginalized communities are also unduly impacted by false narratives around SRHR, including: SRHR is separate from racial justice or only a “woman's issue”; abortion bans are about “protecting babies,”; or abortion is a moral and religious imperative. Control over our bodies is fundamental to liberation, and these narratives not only impede—but disproportionately so—people's ability to live freely. Support the showFollow Us on Social: Twitter: @rePROsFightBack Instagram: @reprosfbFacebook: rePROs Fight Back Email us: jennie@reprosfightback.comRate and Review on Apple PodcastThanks for listening & keep fighting back!

Ahwooooooooo there Herders, and welcome back the wolves episode! We have been holding off on all the good episodes for when the deployment ended!Wolf, any of two species of wild doglike carnivores. The gray, or timber, wolf (Canis lupus) is the better known. It is the largest nondomestic member of the dog family (Canidae) and inhabits vast areas of the Northern Hemisphere. The Ethiopian, or Abyssinian, wolf (C. simensis) inhabits the highlands of Ethiopia; until recently it was considered a jackal. Pervasive in mythology, folklore, and language, the gray wolf has had an impact on the human imagination and has been the victim of levels of misunderstanding that few animals have shared. With the exception of humans and the lion, the gray wolf 

Today I share a lot more about how I experience PDA as an adult, what triggers it and how I am learning to manage it day to day.Toni's email is autisticat40@outlook.com. Instagram is @autistic_at_40_podcast.You can support this podcast and the free online community, Autistihood, here: buymeacoffee.com/autisticat40

Warning: This episode contains profane language and detailed descriptions of sexual assault allegations.More than 20 women say a man who went by Officer “Champagne” sexually assaulted them while they were held at the Rikers Island women's jail. Their allegations span decades and they are now suing the city for more than $500 million. But the Department of Correction says there was no one with that name who worked there during that time.WNYC spoke with several women who say they were assaulted by Champagne, and started to unravel the mystery. Who was Correction Officer Champagne?What the WNYC investigation found led to more questions — including why city officials have done so little to investigate more than 700 recent claims of sexual assault at the troubled jail?.Related links:He was Officer 'Champagne' at Rikers. 24 women accused him of sexual assault in jailRikers guard charged with rape while off duty has a string of accusations from detaineesCREDITSReporter: Jesse EdwardsEditor: Christopher WerthExecutive producer: Ave CarrilloProducer: Jared MarcelleContributors: Jared Marcelle, Samantha MaxTechnical Director: Wayne ShulmisterAudio Mixing: Wayne Shulmister, Liora Noam-KravitzMusic: Jared Paul, Owen KaplanEpisode art: Rhe CivitelloThanks to:  Sean Bowditch, Stephanie Clary, Audrey Cooper, Lauren Cooperman and Ann Givens Tell us what you think. We're @noteswithkai on Instagram and X (Twitter). Email us at notes@wnyc.org. Send us a voice message by recording yourself on your phone and emailing us, or record one here.Notes from America airs live on Sundays at 6 p.m. ET. The podcast episodes are lightly edited from our live broadcasts.

Amazon says get in the office… Jeff Bezos falls to third… Security for Elon, Jeff and Mark… Mark Davis says it wasn't about the money… RFK Jr. being investigated… chewingthefat@theblaze.com Off The Record with Pat Gray tomorrow... www.blazetv.com/jeffy Promo Code: Jeffy40 / $40 off ( as long as it lasts )... Tomorrow is National Cheeseburger Day… Stouffers Box Mac and Cheese hitting the shelves.. New episodes of Only Murders in the Building / Tulsa King / The Old Man / The Penguin starts up / Dexter is back and not dead… Oceangate hearing is two weeks?... NYC fire chiefs arrested for corruption… Boeing strike affecting entire company… Sean “Diddy” Combs in a tad bit of trouble… Social post about Heinz and Hunts… NCAA top 25… Joke of The Day from Paul… Learn more about your ad choices. Visit megaphone.fm/adchoices

A reading and discussion inspired by Ikigai's Travis Kling https://x.com/Travis_Kling/status/1830981118566244633 Enjoying this content? SUBSCRIBE to the Podcast: https://pod.link/1438693620 Watch on YouTube: https://www.youtube.com/nathanielwhittemorecrypto Subscribe to the newsletter: https://breakdown.beehiiv.com/ Join the discussion: https://discord.gg/VrKRrfKCz8 Follow on Twitter: NLW: https://twitter.com/nlw Breakdown: https://twitter.com/BreakdownNLW

Nonfiction writer Alissa Quart joins co-hosts V.V. Ganeshananthan and Whitney Terrell to discuss how the American obsession with “bootstrap narratives” led to the publishing industry championing Hillbilly Elegy, the bestselling and problematic memoir by J.D. Vance, who was subsequently elected to the Senate and is now the Republican vice presidential nominee. Quart talks about Vance's failure to credit those who have contributed to his success and reflects on both the fetishization of poverty and the importance of authentic representation. She also explains the long tradition of self-made man narratives and their underlying queer romantic elements, and compares Vance's work to that of writers like Laura Ingalls Wilder and Horatio Alger. She critiques Vance's recent remarks about childless and professional women and suggests the need for a more nuanced and expansive understanding of community. Quart talks about the nonprofit she leads, the Economic Hardship Reporting Project, and reads from her book, Bootstrapped: Liberating Ourselves from the American Dream. To hear the full episode, subscribe through iTunes, Google Play, Stitcher, Spotify, or your favorite podcast app (include the forward slashes when searching). You can also listen by streaming from the player below. Check out video versions of our interviews on the Fiction/Non/Fiction Instagram account, the Fiction/Non/Fiction YouTube Channel, and our show website: https://www.fnfpodcast.net/ This episode of the podcast was produced by Anne Kniggendorf. Alissa Quart Bootstrapped: Liberating Ourselves from the American Dream Thoughts and Prayers  Squeezed: Why Our Families Can't Afford America  Monetized  Republic of Outsiders: The Power of Amateurs, Dreamers, and Rebels  Economic Hardship Reporting Project   "JD Vance is the Toxic Byproduct of America's Obsession with Bootstrap Narratives" | Literary Hub Others: Laura Ingalls Wilder Horatio Alger Barbara Ehrenreich Dorothy Allison Elizabeth Catte Alex Miller Bobbi Dempsey Ann Larson Fiction/Non/Fiction Season 6, Episode 32: “The East Palestine Train Derailment and Your Health: Kerri Arsenault on the Pervasive and Ongoing Risks of Dioxin”  “‘Dangerous and un-American': new recording of JD Vance's dark vision of women and immigration” by Jason Wilson | The Guardian Hillbilly Elegy: A Memoir of a Family and Culture in Crisis Going for Broke with Ray Suarez | The Nation Going for Broke | NPR Learn more about your ad choices. Visit megaphone.fm/adchoices

For this hour, we hear from two Muslim women who resigned from the Biden administration in reaction to the administration's support for the genocide in Gaza. Maryam Hassanein, was a special assistant in land minerals and management at the Department of the Interior. Hala Rharrit is a former career diplomat with 18 years in the U.S. Foreign service. Her last assignment was as an Arabic language spokesperson for the State Department in the United Arab Emirates. In April 2024, Rharrit became the first American diplomat to publicly resign in protest of the Biden administration's Gaza policy, condemning it as failed, illegal and inhumane. They were both interviewed in an online forum sponsored by CAIR, the Council on American-Islamic Relations, on Tuesday, August 27, 2024.  The show is made possible only by our volunteer energy, our resolve to keep the people's voice on the air, and by support from our listeners. In this new era of fake corporate news, we have to be and support our own media! Please click here or click on the Support-Donate tab on this website to subscribe for as little as $3 a month. We are so grateful for this small but growing amount of monthly crowdsource funding on Patreon. PATREON NOW HAS A ONE-TIME, ANNUAL DONATION FUNCTION! You can also give a one-time or recurring donation on PayPal. Thank you!

The past ten days have been some of the most historic AND bizarre of our lifetimes. Pervasive corruption continues to be revealed, and democracy continues to be challenged--but not by the "villain" many thought was the tyrant. We talk about all of this and more and invite you into the conversation.

You can put your hope in God's unfailing love. God cares for the lonely, heals the brokenhearted, and uplifts the humbled. In today's message, we will discuss Psalm 25 and the truths of the 3Ps of anxiety: Personal, Pervasive, and Permanent. For more information, visit lakepointe.church/dailydrive

Nurses Out Loud with Melissa Schreibfeder, BSN, RN – In today's world, we face the pervasive threat of toxicity from chemicals and pollutants. With less than 1% of over 85,000 chemicals tested for safety, the health risks are significant. Minimizing exposure and supporting the body's detoxification through organic foods, non-toxic products, and essential nutrients can help reduce this toxic burden and promote well-being...

"I just called out to Heavenly Father and said, help. I was very aware that there were angels all around me protecting me, I knew that Heavenly Father was rescuing me. He was hearing my prayer and That black feeling immediately was replaced with warmth, and love, and total mercy. It was like, I've been waiting for you, I got you. And I just was totally honest with Him and I told Him everything that I needed to say. I told him 'I'm so insecure. I don't know how to do this. I don't know who to be. I don't know how to commit to being a good girl. I don't know what that looks like. I'm attracted to all of these things that I don't know how to reconcile.' I just didn't know what to do next, but I knew that I couldn't continue in that life that I was in. I was so honest and submissive and just like, I'm gonna give this all to you and you help me figure out what to do next. And it was beautiful, it was amazing, it was the most sacred thing that's ever happened in my life. Then I felt like I should go see a bishop." Come Back Team: Director, Founder & Host: Ashly Stone Producer and Senior Editor: Lauren Rose Outreach Manager: Jenna Carlson Editor: Michelle Berger Art Director: Jeremy Garcia