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Dr Deb Muth 00:03Well, welcome back to Let’s Talk Wellness Now. I am your host, Dr. Deb. And what is the most talked-about peptides in functional medicine? aren’t actually FDA approved. Not because they don’t work, but because no one’s funded the research to prove it yet. The truth is, some of the compounds that dominate wellness forums, BPC-157, TB-500, thymosin beta-4, epitalin, occupy a fascinating space between breakthrough science and unregulated experimentation. In today’s episode, we’re stepping into that grey zone, the world of investigational peptides, to separate mechanism from marketing. I’m going to walk you through the science that actually shows and where it stops, how to evaluate claims when human data don’t yet exist, and the quality, purity, and safety red flags that you need to recognise. Dr Deb Muth 01:06I created it in a previous episode, so go check that one out. And why honesty is the most important prescription in peptide medicine. If you’ve ever wondered whether these research-only peptides are the frontier of healing or the next functional medicine fad, this episode is for you. So grab your cup of tea or coffee, get comfortable, and let’s talk about what it really means to use peptides that are promising but still under investigation. So we’re going to break just for a second here and have a word from our sponsor. It is because of them that we stay on the air. So thank you for this. And we will be right back. Did you know sweating can literally heal your cells? Infrared saunas don’t just relax you. They detox your body, balance hormones, and boost mitochondrial energy. I’m obsessed with my Health Tech sauna. And right now, you can save $500 with my code at healthtechhealth.com slash dr-muth-req-25. Dr. Deb Muth 02:15All right, guys, welcome back. Let’s dive into investigational peptides, the evidence gap. So the following peptides we’re about ready to discuss are extensively in integrative, functional, and regenerative medicine circles. They may have intriguing mechanisms and promising preclinical data. However, they lack FDA approval, and the evidence quality varies dramatically. from interesting preliminary research to essentially no human data at all. And this distinction is really critical for maintaining scientific integrity. So let’s talk about immune-modulating peptides. There’s thymus and alpha-1, and this is an international story on the thymic peptides. Thymusin alpha-1, known as TA1, is marketed internationally as zidaxin. Dr. Deb Muth 03:16It’s a 28-amino acid polypeptide originally isolated from thymusin fraction 5, which was extracted from bovine thymus tissue. Modern production uses synthetic peptide synthesis. The thymus gland is located behind the sternum and is the primary site for T cell maturation, and thymic peptides like TA1 play roles in human system development and regulation. Now, I love thymus peptides. I love thymus glandular products. I’ve used thymus glandular products for decades. Ground-up animal thymus gland is basically what it is. There are a couple of different supplement companies that I’ve used over the years that are amazing with this. And they do a fantastic job, and they really do help to support the immune system. So when thymus peptides came out, it was really exciting because it took the whole idea of thymus support to a new level. Dr. Deb Muth 04:17The mechanism actually behind the thymus in alpha-1 is complex and involves multiple aspects of immune function. At the cellular level, TA1 enhances T cell maturation and differentiation, particularly the development of helper T cells and cytotoxic T cells. It modulates T cell receptor expression and can influence the balance between Th1 cell-mediated immunity and Th2 humoral immunity responses. And it also enhances the natural killer cell activity and modulates dendritic cell function, which are critical for antigen presentation. and initiation of adaptive immune responses. And on the cytokine level, TA1 influences production of interleukin-2, IL-2, interferon gamma, IFN-γ, and interleukin-10, IL-10. Dr. Deb Muth 05:19These create immune modulatory rather than simple immune stimulatory effects. This is a very important distinction because TA1 appears to help balance the immune system rather than simply ramping this up, which theoretically makes it safer in conditions where immune overstimulation would be a problem, such as an autoimmune disease. Hashimoto’s, autoimmune, lupus, Sjogren’s, any of those autoimmune diseases, we don’t want to overstimulate their immune system. So you want to use a product like this that’s non-stimulating. Now, the regulatory status on TA1 is geographically variable and represents one of the challenges in discussing this peptide with patients. It is not FDA-approved in the United States. However, it is approved in several other countries for specific conditions. Dr. Deb Muth 06:19In Italy, it’s approved for the treatment of chronic hepatitis B and hepatitis C. In China, it’s approved for chronic hepatitis B and adjunct immune compromised patients receiving vaccinations or suffering from certain infections. It has an orphan drug designation in the United States for certain cancer indications, but its designation does not constitute approval. It simply provides regulatory incentives for further development. So the evidence base for thymosin alpha-1 is substantial in some areas but comes primarily from non-US populations and research groups, which creates challenges in evaluating quality and generalizable information. So in hepatitis B and C, multiple clinical trials, many conducted in China and Italy, have examined TA1 as an adjunct to antiviral therapy. Dr. Deb Muth 07:21A meta-analysis by Wu and colleagues published in the Journal of Viral Hepatitis in 2013 examined 23 randomized controlled trials, including over 2,000 patients with chronic hepatitis B. The analysis found that combining TA1 with nucleoside analogs like LAMVDUDE or an and TCAVAR improved the hepatitis antigen seroconversion rates by HBV DNA clearance compared to its nucleoside analogs alone. And the effect sizes were modest but statistically significant, with the HBE-AG seroconversion rates improving from about 24% with antivirals alone to 38% in combined therapy. Now in hepatitis C, early trials before the development of direct-acting antivirals showed that TA1 combined with interferon alpha improved sustained virological responses, and compared to interferon alpha, Dr. Deb Muth 08:30Furon alone, particularly in difficult-to-treat populations like those with a genotype one or a high viral load. However, the advent of highly effective direct acting antivirals that achieve SRV rates, sorry, SVR rates exceeding 95%, the role of TA1 in hepatitis C has become less clear. Now in sepsis and critical illness, more recent interest has focused on TA1 in severe cases of sepsis and septic shock. Ren and colleagues published a systematic review and meta-analysis in the Frontiers of Immunology in 2022, analyzing 18 randomized controlled trials, including 1787 patients with severe sepsis or septic shock the pooled analysis showed that ta1 administration was associated with reduced 28-day mortality relative risk at 0.70 meaning a 30 reduction in mortality compared to the standard care alone and the effect appeared Dr. Deb Muth 09:39most pronounced in patients with sepsis-induced immunosuppression measured by HLA-DR expression in monocytes. Now, this is amazing because going forward, we’re going to talk about something that’s commonly known as cytokine storm. Now, cytokine storm really became apparent since 2020 with the viral infection that we’re dealing with in the world today. But they were already looking at this kind of cytokine storm produced by sepsis or sepsis-induced immunosuppression. And it triggered this hyperinflammatory response called the cytokine storm. And many patients who survived the initial phase of the immune suppressed stata, characterized by a T cell exhaustion, reduced antigen presentation, and increased susceptibility to secondary infections. Thymusin alpha-1, TA1, may help restore this immune competence in this phase. However, it’s important to note that patient selection and timing are critical. Dr. Deb Muth 10:43Giving this immune stimulant during a hyperinflammatory phase could theoretically worsen outcomes. So you don’t want to give it to them while they’re in the flare up or the sepsis or the infection, but given to them during the immunosuppression phase afterwards might be beneficial. Now there is also some cancer immunotherapy that we see with TA1 and has been studied as an adjunct in cancer treatment with the hypothesis that it could enhance immune surveillance and response to tumors. And a comprehensive review of Garci and colleagues published in Expert Opinion on Biological Therapy in 2007 examined multiple trials in melanoma, lung cancer, hepatocellular carcinoma, and other malignancies. And the results were mixed. Some trials showed improvement in the immune parameters, increased CD4 in T-cells. improved lymphocyte proliferation responses and some actually showed trends toward improved progression free survival but overall survival benefits were inconsistent and the heterogeneity of the cancer types treatment protocols and outcome measures makes a definitive conclusion difficult as a vaccine adjunct several studies particularly from china have examined ta1 as an adjunct to enhance vaccine responses Dr. Deb Muth 12:11in immune-compromised populations, including the elderly, dialysis patients, and transplant recipients. The rationale is sound. These populations often mount suboptimal antibody responses to vaccines, and TA1’s immune-enhancing effects might improve protection. There are small trials. They have shown improvement in seroconversion rates of hepatitis B vaccines and influenza vaccine in these populations. And though large-scale confirmatory studies are limited, there is a possibility here. Now, on their safety profile, one of the appealing aspects of thymusin alpha-A TA1 is that it’s apparently favorable safety profile in clinical trials. There are some injection site reactions with a little redness, a mild discomfort, and most commonly reported adverse effects. is that their severe adverse events attributable to TA1 have been rare in published trials. However, comprehensive long-term safety data are limited Dr. Deb Muth 13:13And theoretically, concern exists that immune modulation could potentially trigger or exasperate autoimmune conditions in susceptible individuals. Though this hasn’t been clearly demonstrated in clinical trials, integrative medicine considerations for integrative practitioners concerning the thymus and alpha-1, several factors require careful thought. First, sourcing and quality control are critical concerns. Since it’s not FDA approved, TA1 available in the United States typically will come from a compounding pharmacy or an international supplier with variable quality assurance. And pharmaceutical grade product with certificates of analysis showing purity, sterility, and endotoxin testing is essential, but it is readily available from many of these companies. Second, patient selection matters immensely. TA1 should be considered in complex cases where conventional approaches have been insufficient, such as chronic viral infections not responding adequately Dr. Deb Muth 14:21to standard antivirals, post-viral syndromes with evidence of immune dysfunction, cancer patients with immune suppression in consultation with oncology, and it should generally be avoided in active autoimmune disease unless there’s a compelling rationale and close monitoring. Now, TA1 is not a standalone therapy. In cases of chronic viral infection, Comprehensive immune support includes addressing nutritional deficiencies, optimizing vitamin D levels to be between 50 and 80, adequate zinc, selenium, and vitamin A, optimizing gut health since 80% of our immune function is in the gut, you need to optimize gut function. Managing stress from the HPA access dysfunction, chronic cortisol elevation, suppression, and immunity, ensuring adequate sleep, immune memory consolidations during sleep, addressing any metabolic dysfunction, insulin resistance, repairs in the immune function, and the bottom line on thymus and alpha-1 is Dr. Deb Muth 15:26is that it represents legitimate medicine in other countries with a substantial evidence base in specific contexts, but it remains experimental in the U.S., and practitioners using it should provide comprehensive, informed consent about its regulatory status, evidence quality, and source verification. while ensuring it’s part of comprehensive protocols. It is not a magic bullet. And again, what you’re gonna hear me say quite often here is that many of these peptides should be used in conjunction with something else. They should not be used alone. And can peptides be stacked? The answer is yes, they can. So if somebody has an insulin resistance, or a metabolic dysfunction, they can tier TA1 with a GLP-1 like terzepatide or semiglutide. That is not a problem to do that. You need to just work with a practitioner that understands how to do that effectively. So let’s look at BPC-157. Dr. Deb Muth 16:26This is a phenomenon I love BPC-157. Let’s separate it from marketing to actual mechanism of actions here. So BPC-157 stands for Body Protection Compound 157. It is a chain of 15 amino acids that are described as a partial sequence of body protection compound, a protein found in human gastric juice. It has become one of the most hyped peptides in regenerative medicine inside the athletic performance and biohacking communities with claims ranging from healing tendons and ligaments to repairing gut lining or reversing organ damage. The challenge is separating the legitimate mechanisms of science from the marketing hype. The proposed mechanism of BPC-157 are biologically plausible and intriguing. The research suggests that it may influence several growth factor pathways, including vascular endothelial growth factor, VEGF, which promotes new blood vessel formation and has improved better supply of blood flow to injured tissues, theoretically accelerating healing. Dr. Deb Muth 17:40It may also affect fibrous blast growth factor, FGF, and transforming growth factor beta, TGF beta pathways. both involved in tissue repair and remodeling. And some studies actually suggest that BPC-157 modulates inflammatory cascades, potentially reducing excessive inflammation while promoting the resolution phase that allows tissue rebuilding. Now I want to talk just a few moments here about these different tests that we’re talking about tgf beta veg f for those of you who are in our mold world you are very familiar with these uh lab tests we do this to see if you have a mold exposure what’s happening to your body and it’s been very challenging to try to heal this part of the mold illness and manipulate these VEGFs and TGF betas. And so with the fact that BPC helps us modulate this inflammatory cascade, BPC can be very helpful in the world of mold or mycotoxin illness in repairing those parts of the body that have been damaged by the mycotoxins. Dr. Deb Muth 18:48Now there is animal research on BPC-157. It is extensive and primarily from a research group led by pre-drag, oh, I can never say these names, Cyrek at the University of Zagreb in Croatia. Published studies in animal models have shown accelerated healing in a remarkable variety of injury types. A 2011 paper by Chang and colleagues in the Journal of Applied Physiology demonstrated that BPC-157 improved therapy tendon healing in rats with Achilles tendon injuries, and the treated rats showed increased tendon outgrowth, better cell survival in the injured area, enhanced cell migration to the injury site, and improved biochemical strength of the healed tendon compared to controls. Multiple other animal studies have shown similar promising effects. Ligament tears, healing faster in rabbits, muscle damage recovering more quickly in rodent models, gastric ulcers healing in rats given experimental induced ulcerations, inflammatory bowel lesions improving in mouse models of colitis, and even bone to tendon healing showing enhancement in animal studies. Dr. Deb Muth 20:02The breadth of injury types showing benefit in preclinical models explains the enthusiasm of this peptide. However, this is critical. These animal studies, primarily in rodents and rabbits, animal models of injury healing don’t reliably translate to human clinical outcomes. And the doses used in these animal studies when converted to human equivalent doses vary widely. And optimal human dosing is completely unknown at this point. it is all considered experimental and perhaps most importantly there are essentially no peer-reviewed controlled clinical trials in human published in humans published in major medical journals in a 2001 review of arthroscopy and the journal of arthroscopic and related surgery specifically examined in the evidence of bpc 157 and other peptides in musculoskeletal medicine The authors concluded bluntly that BPC-157 lacks evidence from randomized controlled trials and has an unknown safety profile in humans. Dr. Deb Muth 21:09 They emphasized that the jump from animal data to recommending peptides for humans use bypasses the fundamental requirement for Phase I safety studies, Phase II dose-finding studies, and Phase III efficacy trials that would establish whether BPC-157 actually works in humans and whether or not it’s safe. The absence of human safety data is particularly concerning given BPC-157’s proposed mechanisms. Peptides that influence growth factor signaling and angiogenesis could theoretically have off-target effects. Uncontrolled angiogenesis, for instance, is a hallmark of cancer progression. Tumors require blood vessel formation to grow beyond a certain size. And while there’s no evidence that BPC 157 promotes cancer, The complete absence of long term human safety studies means we simply don’t know. This isn’t fear mongering. It’s acknowledging uncertainty and uncertainty exists and understanding that if you’re choosing to use peptides like BPC 157, you are doing it in an experimental model. Dr. Deb Muth 22:17We’re experimenting with the doses that are being used. And there is potential for it to cause cancer cells in your body to grow. And you need to be aware of this and understand the risks that you’re taking when you’re using an investigational or off label use peptide. Now, quality control issues with BPC also exist. It’s not FDA approved for any indication in the US. It’s not approved in any major regulatory jurisdiction worldwide. It’s marketed as a research chemical explicitly to bypass FDA oversight. And commercial sources selling BPC-157 range from compounding pharmacies, which have some quality standards but are not FDA inspected. You can take that for what you want to believe on that one. to overseas suppliers operating with absolutely no quality assurance whatsoever. If you are choosing to use BPC-157, you have to understand who’s manufacturing it for you, where you are getting it from, how pure it is. Dr. Deb Muth 23:26You want to make sure that you have the certificate of analysis and that it does not contain bacterial endotoxins that can contaminate the peptide or degrade the peptide and cause other issues for you. So when you talk about peptides with patients regarding BPC-157 or if you’re listening to this and you’re already using BPC-157 or other peptides, that are quote-unquote not for human consumption, an evidence-based response acknowledges both the appeal and the limitations. And you want to talk about the animal data that’s definitely showing some progress and some potential, but we don’t know what we don’t know in humans. If people are willing to take that risk, that is up to them to do that. But using BPC right now is experimental and people need to be aware of that. Are there evidence-based alternatives for patients with tendon or ligament injuries? Dr. Deb Muth 24:26And there are. There’s PRP, which has been studied in multiple randomized controlled trials. for conditions like lateral epicondylitis, tennis elbow, Achilles issues, patellar issues, knee issues. However, I want to caution you on this too. So the study that was done by Cox and colleagues in muscles, ligaments, and tendons in the Journal of 2014 showed modest benefits in pain and function compared to controls. And though the effects vary by injury type, PRP preparations can be helpful. You have to understand that a lot of times when people are doing PRP injections in their office, they are not doing it exactly the same way it was done in the study. And not to mention, if you’re using your own PRP to heal a ligament or a tendon or help your arthritis and you’re 60 or 70 years old, That is not good quality protein rich plasma. It is old protein rich plasma. And you’re not going to see necessarily the same benefits that you would see if you were using placental tissue or umbilical tissue. Dr. Deb Muth 25:33You also want to address the nutritional deficiencies or support that’s needed for connective tissue healing. And these are collagen peptides dosed at 15 grams a day. And this has been shown in a study by Shaw and colleagues in the American Journal of Clinical Nutrition in 2017 to augment collagen synthesis when combined with intermittent loading. Vitamin C is also an essential cofactor for collagen production and stabilization of collagen structure at a dose of around 500 to 1000 milligrams a day to support this process. You also need to have good adequate intake of copper and zinc. These are cofactors in collagen. Silica is also important. This comes from horsetail extract. This provides additional support as well. So more importantly, I think remembering that rehabilitation matters as well. Doing these protocols without doing some rehab is not going to get you where you want to go. Dr. Deb Muth 26:33There’s a research study by Alfredson and others for Achilles tendinopathy using the control lengthening of muscle tendon units under load to promote tendon remodeling and healing. These protocols have solid evidence and cost nothing beyond professional guidance from a physical therapist. They are important for patients seeking cutting edge regenerative approaches. Stem cell therapies, growth factors, concentrates derived from patients’ own tissues like PRP. These have a lot of good endogenous materials and they have good safety profiles. BPC-157 represents the perfect example of how promising Preclinical science gets marketed far beyond the evidence and it may eventually prove to be valuable. I think it will. But right now that determination does require some human studies and hopefully with the administration that we have right now and Bobby Kennedy, we will actually start to see some of that occur. Now the next peptide I want to talk about is TB4, thymus and beta-4. Dr. Deb Muth 27:36This is a wound healing peptide. It is a 43 amino acid peptide that’s naturally present in virtually all human cells except red blood cells. It’s actually one of the most abundant peptides in the human body, particularly concentrated in blood platelets, wound fluid, and many tissues. It’s naturally ubiquity makes it mechanistically interesting. The body wouldn’t produce it in such abundance if it didn’t serve a function. So the primary role of TB4 involves building G-actin. It’s a form of monomeric actin. And it’s structural protein that forms the microfilaments within the cells, providing cellular structure and enabling cell movement. TB4 prevents from F-actin filaments. I’m not going to talk too much about this. It’s really critical for wound healing as cells need to migrate into the injury sites. Dr. Deb Muth 28:37so the cell shape changes and the cellular response to the injury. So think of this as though you tore your meniscus and the body created all this TB4 to come to that injury to try to heal that site. That’s exactly what the TB4 is doing inside the body when there’s an injury. It’s been shown in research to help produce new blood vessel formation, promote endothelial cells, It helps modulate inflammatory cytokines, potentially reducing TNF-alpha, IL-1, and possibly protecting in programmed cell death, which we call apoptosis. And some studies suggest that it is cardioprotective in its effects in animal models of myocardial infarction, so heart attack, and neuroprotective in other models for brain injury. Now, these remain to be preliminary, but they are being seen. So the regulatory status on TB4 can create some confusion. Dr. Deb Muth 29:40The natural TB4 molecule itself is not FDA approved as a drug. However, TB4 based drug candidates called RGN259, formerly TB4, has been in the development by regen tree for corneal injuries of the dry eye disease. And as of recent updates, this drug is completed phase three trials for its neurotrophic keratopathy, severe corneal condition. But the FDA approval is still pending. So that means that the most advanced TB4-based pharmaceuticals hasn’t yet crossed the finish line for approval. The commercial peptide market further muddies the picture with TB500, which is often described as the synthetic fragment of TB4. However, this extract’s relationship between TB500 and TB4 varies depending on the source. Dr. Deb Muth 30:41So some claim that TB500 is identical to TB4, but positions 1 through 4 suggest it’s a different fragment. and the quality control across suppliers is not existent. So this confusion is part of why recommending TB500 becomes problematic for practitioners and patients, often because they aren’t certain what molecule they’re actually getting. The evidence base for TB4 in humans is limited, primarily to eye research, and the studies from Sohn’s and colleagues published in journals like Vitamins and Hormones in 2016 have examined topical TB4 for corneal injuries and neurotrophic keratopathy, dry eye, and other surface diseases. Now, these studies showed some promise in promoting this, and there is, however, a topical application to the cornea that is vastly different from a systemic injection. So for systemic use in wound healing, musculoskeletal issues, Dr. Deb Muth 31:42cardiac protection, neuroprotection, human clinical trials. There is scarce to non-existent evidence in humans. Most of the evidence remains in animal models or cell culture studies. And a review by Flip and colleagues in the Journal of Investigational Dermatology in 2006 detailed TB4’s effects on the matrix remodeling during wound repair in animal models, showing effects on collagen disposition, granulation, tissue reformation, and wound contraction. Another review by Ho and colleagues in expert opinion on biological therapy in 2007 discussed TB4’s potential in tissue regeneration and regenerative medicine, but noted the field remained largely blank. preclinical. So this is really important again to understand that there is just not enough human data. So there is a concern with cell division and migration. This theoretically exists Dr. Deb Muth 32:45for the potential effects on cancer cells, which would also rely on migration and division and other intended consequences of disrupting normal cellular architecture. These aren’t proven risks, but they are unexplored questions that we need to be aware of when we’re using peptides. This can cause cancerous tissue to grow. Very similar to what we talked about with BPC-157. These are also sold as research chemicals. There is no FDA oversight. So purity, potency, contaminations all still exist for these peptides. Now from an integrative perspective, the natural presence of TB4 in wound fluid and its biological roles in healing are legitimate science. in presence does not equal therapeutic utility. The body tightly regulates where and when and how much TB4 is present through natural production and bypassing that regulation with external dosing may or may not cause us to have beneficial or introduce risk. Dr. Deb Muth 33:49So we need to know that this is experimental use. Those people who are seeking wound healing and tissue repair the evidence-based approach of the body’s own capacity to heal is huge definitely want to be increasing your protein intake optimizing your zinc copper vitamin c and vitamin a and then managing glucose is really important during this time as well so let’s talk about a fun topic now and that’s growth hormone secretagogues this is the anti-aging hype machine these peptides in this category are things like semoralin ipameralin cjc 1220 1295 and others and among the most aggressively marketed in anti-aging and longevity medicine they all share a common goal stimulating the pituitary gland to release more growth hormone and the appeal is understandable. GH levels decline with age, and this decline is associated with increased fat mass, decreased lean muscle, reduced bone density, and other aspects of aging. Dr. Deb Muth 34:55The other times we’ll see growth hormone levels decline significantly is with chronic illness, and the logic is to restore youthful GH levels and youthful physiology. Now, semirelin from an FDA approved diagnostic to compound anti-aging product. Semirelin is a 29 amino acid peptide representing the first 29 amino acids of the full 44 amino acid human growth releasing hormone, GHRH. We talked about this on another episode of the podcast. And you can go back and listen to that one a little bit if you want. This fragment contains the complete biological activity of the full GHRH molecule and it binds to GHRH receptors in the anterior pituitary and stimulates growth releasing peptides, growth hormone releasing peptides. Semirelin was previously FDA approved as diagnostic testing of growth hormone secretion, essentially, to determine if the pituitary could still respond to GHRH stimulation in patients being evaluated for growth hormone deficiency. Dr. Deb Muth 36:06However, the manufacturer was discontinued and there was no longer an FDA approved semirelin product on the market in the United States. What exists now is semirelin available from compounding pharmacies used off label for anti-aging, body composition, and general growth hormone optimization purposes. This represents a significant gray area. Again, compounding medications serve a very important role, but they need to meet certain recommendations and regulations, as we’ve talked about in the past. You want to make sure that your compounding pharmacy that you’re obtaining semirelin from is qualified to do that, that they are doing best practices, and that you’re getting a good product. The theoretical advantage to semirelin over direct growth hormone administration is that it preserves more of the physiological growth hormone secretion patterns. Natural GH is released in pulses, primarily during sleep, not as a continuous elevation. Dr. Deb Muth 37:07So semirelin stimulates the pulses rather than providing a constant super physiological growth hormone level. And that pulsatile pattern is thought to reduce some of the side effects and metabolic concerns that we have with continuous growth hormone exposure. However, the evidence supporting semirelin for anti-aging and body composition in healthy adults is minimal. Most of the data comes from studies conducted in the 1990s when the FDA approved product existed. Not that that means it’s bad. We have drugs that have been in the market for over a hundred years that are still there, that still have the research and are still being used successfully and safely today. So we don’t want to let that really make us think that this product isn’t safe. So a 2006 review from Walker in Clinical Interventions of Aging suggested that semirelin might be a better approach than direct GH for adult onset growth hormone insufficiency, but they do acknowledge that the evidence was limited. Dr. Deb Muth 38:12And although we don’t have any large scale trials that we can examine for semirelin’s efficacy, it is now commonly prescribed. And the optimal dosing for anti-aging purposes is still unknown. It is considered experimental and it does vary from person to person, but it is still unstudied. The effects on cancer risk, cardiovascular disease, metabolic dysfunction over long time periods are also still unknown. I would argue that the side effects or the risk factors of not having growth hormone are equally as bad as the unknowns that we have here. We’re not looking to try to get super physiological doses. We’re trying to restore youthful GH levels. Typically, we’re not trying to restore back to a 20-year-old. We’re trying to restore back maybe 10 years. That is a better way of doing this. And I think that’s important for people to understand. Now, ipamirelin is the ghrelin mimicker. Dr. Deb Muth 39:12Ipamirelin is a pent-up peptide, five amino acid, that acts as a growth hormone secretagogue receptor, a GHS-R agonist. It mimics the action of ghrelin, the hunger hormone, that also stimulates growth hormone release. The proposed advantage over earlier secretagogues is that ipamirelin stimulates growth hormone release without significantly affecting cortisol, prolactin, or other glucose things, which can be increased by growth hormone secretagogues. The regulatory status is clear. Ipamirelin is not FDA approved for any indication. It’s sold as a research chemical. Human evidence is thin. It’s limited to single dose studies examining how quickly it’s absorbed and metabolized with minimal data on dosing and clinical outcomes. Now there are marketing claims for ipamirelin and they are extensive. Dr. Deb Muth 40:13It increases lean muscle mass, it decreases body fat, it improves sleep quality, faster recovery from workouts, enhanced injury healing, better skin quality. The evidence supporting these claims in humans is not available we don’t have it these are claims that are made by the effects that we know from growth hormone so it’s not necessarily a bad thing we know what growth hormone does we know growth hormone does all of these things if ipamorelin is a precursor to that it will obviously help improve those things making that correlation of what growth hormone does So there are safety concerns that mirror the same as any other growth hormone elevating therapy. It can cause fluid retention, joint pain, carpal tunnel syndrome, insulin resistance, glucose intolerance, and theoretically, can it increase calcium? cancer risks? It can because IGF-1 promotes cell proliferation and can inhibit apoptosis in cancer cells. Now remember, your body makes IGF-1. Dr. Deb Muth 41:15If it’s not making enough of it, that’s a problem. If it’s making too much of it, That’s a problem. So just understand that if you are adding these things, and especially in elevated doses, you are taking a potential risk. So there is also now CJC 1295 is a modified GHRH analog of 30 amino acid peptide based on GHRH structure, but with modifications. So it includes the addition of drug affinity complex, DACC, DAC, which involves conjugation with a small albumin binding molecule, dramatically extends the peptide’s half-life from minutes to as much as potentially a week or more. And this creates sustained growth hormone elevation rather than that pulsatile release. There are actually two versions of this. There’s CJC 1295 with DAC, longer acting version, and CJC 1295 without DAC, which is essentially a shorter duration of semirelin. Dr. Deb Muth 42:19And so when we’re comparing products, it is… only the difference between long acting and short acting. The human evidence for CJC 1295 is limited to a single published phase one study by Techman and colleagues in the Journal of Clinical Nutrition and Metabolism in 2006. And the study involves 18 healthy young adults showed that CJC 1295 with DAC produced a sustained elevation of GH and IGF-1 lasting several days after the injection. That’s essentially the entire published human evidence of this peptide. There are no phase two studies examining optimal dose. So that is all considered experimental. And there is no phase three studies examining clinical efficacy. So the sustained GH levels created by CJC 1295 with DAC raises specific concerns because the natural GH secretion It goes up and down, up and down, up and down. Dr. Deb Muth 43:19And that constant elevation may have a different metabolic and cellular effect. And we just really don’t know what that’s going to be yet. So we can understand that elevated IGF-1 levels can theoretically increase cancer concerns and metabolic risks. So rather than always injecting peptides, which are very expensive… You can do other things. And there was a study by Hartman and colleagues in the Journal of Clinical Endocrinology and Metabolism in 1992 that demonstrated the 48-hour fast increased integrated growth hormone secretion five-fold through increased GH levels. Now, the problem with this is fasting for 48 hours is a challenge. And how long is it going to increase the growth hormone secretion without causing issues? Or in general, how long is it going to go up? Dr. Deb Muth 44:19So we have to be cautious about that as well. Sleep optimization is non-negotiable. The majority of growth hormone secretion occurs during sleep, slow wave sleep, typically the first sleep cycle, and poor sleep quality or insufficient sleep typically. can dramatically affect your growth hormone levels. And then high intensity interval training, HIIT resistance training can stimulate growth hormone as well. This was seen in a study by Godfrey and colleagues in sports medicine in 2003 and was examined in exercise-induced growth hormone responses to athletes. So we definitely see these kinds of things. So let’s talk about some longevity peptides now. These expand the telomere. So there’s epitalin and epithalamin and when these are used in anti-aging they can produce some amazing results. Dr. Deb Muth 45:22So epitalin is a synthetic terapeptide, just four amino acids. It was originally synthesized as a simplified version of epithalamine. a pineal gland extract containing multiple peptides. The synthetic four amino acid version was created to isolate what researchers believed might be the active anti-aging component. The mechanism produced for epitalin centers on telomere and telomerase, Telomeres are protective caps at the end of the chromosomes consisting of repetitive DNA sequencing. And every time a cell divides, telomeres shorten slightly because DNA polymers cannot fully replicate the ends of the linear chromosomes. So this progressive shortening acts as a molecular clock. After 50 or 70 divisions, the telomeres become critically short, triggering a cellular senescence. Dr. Deb Muth 46:22This telomere shortening is one mechanism of cellular aging and telomeres in the enzyme that can rebuild telomeres by adding these caps back onto the end of the chromosome. It’s active in stem cells, germ cells, and unfortunately in about 85 to 90% of the cancer cells. In most adult somatic cells, telomerase is inactive or present at very low levels, allowing the telomeres to shorten with division. The research on epitalin suggests it might activate this telomeres act telomeres process primarily from a research group led by Vladimir in Russia. Vladimir Kavasan in Russia. He is a huge peptide researcher or was he passed away with publications dating back to the early 2000s and a study published in bio gerontology in 2000 by Kavasan Dr. Deb Muth 47:25and colleagues examined the effect of epitalin on the lifespan of fruit flies, and they treated fruit flies that showed a modest increase in mean and maximum lifespan compared to its controls by approximately 10 to 15% lifespan extension in some experimental groups. And there were other studies in 2003 that examined epitalamine in a female Swiss-derived mouse. This was done by Ann Simove and colleagues. And the researchers reported that epitalin treatment was associated with increased lifespan as well. And the most cited mechanistic work comes from cell culture studies. And that is also Cavason’s group that published this research in 2003, showing increased telomeres activity in cultured somatic cells again. More recently, between 20 and 25, the series of publications have continued to explore epithelial effects on telomere dynamics in cell cultures. Dr. Deb Muth 48:32So there is a lot of research that’s been done. The mass majority has been done on epithelin. And most of it has been done by a single research group in Russia. There is some restrictions on some of the cell culture data that we’re seeing. And it does show that epithelin sometimes can be described as a regulating hormone. Carcadian rhythm for melatonin production, which is derived by the penile extracts. And however the evidence for this affects minimally and mechanistically unclear, the pineal gland primarily functions as melatonin secretion in that light-dark cycles. So Epithalin or epitalin is not FDA approved. It is not approved for any major regulatory jurisdiction. It is sold as a research chemical only. Dr. Deb Muth 49:33So you need to follow the same safety profiles that we’ve talked about in other episodes and in today’s episodes. And when we’re talking about epithalin, and we’re excited about it being an anti-aging science, we should balance this with the honesty and the evidence of the quality of that evidence. We don’t know its safety effect. We don’t know if it’s going to increase the risk of cancer. We can’t verify that. And we need to be using it in an experimental use of unknown risks only. Of course, diet, physical activity, stress management, sleep quality, all of those things are important for us to be looking at when we’re looking at these peptides. Now, I want to get into some of the brain peptides. This is the nootrophic frontier. C-Max and C-Lank, there is Russian pharmacology that’s done. C-Max and C-Lank represent an interesting case study in how different regulatory environments and research traditions Dr. Deb Muth 50:36create challenges in evaluating this evidence. Both peptides were developed in Russia, are approved for their specific indications and have substantial Russian language and literature supporting their use. However, the FDA approval in the United States is still not there. C-Max is a seven amino acid. It’s a synthetic analog. It is a fragment, particularly ACTH 4 through 10. It’s sometimes called the melanocortin effects because it involves the melanocortin receptors of the central nervous system. CMAX was developed by the Institute of Molecular Genetics of Russia Academy of Sciences and is approved in Russia for several indications, including acute stroke, transient ischemic attacks, cognitive disorders. It has Russian approval and is based on clinical trials primarily in Russia. Dr. Deb Muth 51:39It does help to increase brain-derived neurotrophic factor, BDNF, a protein critical for neuroplasticity, the brain’s ability to form new connections and adapt to the challenges. BDNF supports neuronal survival and promotes growth of these new neurons. C-Max also influences neurotransmitter systems, particularly dopamine and serotonin, and there is some research that suggests it affects on metabolism as well, and endogenous opioid peptides that involve pain reception and mood regulation. So it has some good potentials there. There is also C-Link, which is a hepatopeptide structurally similar to Tufts’ and an immune modulatory peptide. It was also developed in Russia and was approved for anxiety disorders as a neurotropic. Its effects involve anxiolytic effects, possibly through the GABAnergic system or the GABA system of the brain, and immune modulation. Dr. Deb Muth 52:44The Russian research is examined by C-Link for anxiety disorders. and finding reductions in anxiety without sedation. There is a dependency potential or cognitive impairment does not exist like it does with benzodiazepines with C-Link. So that is really good. And they do report attention and memory improvement using C-Link. There is a study that was done in neuroscience and behavioral psychology in 2018 that examined C-Linx effects and proposed that it exerts cytoprotective effects through BDNF pathways similar to C-Max. So both of these are Russian research-based They’re not wrong or fraudulent. It’s just that they are from Russia and we all have our concerns with Russia. However, that does not necessarily mean their research doesn’t hold quality. Dr. Deb Muth 53:49Neither peptide is approved by the FDA, and so you are using this off-label. The same rules apply for all of the other peptides that we’ve talked about that are produced off label. You want to do the same things that you would do with anything else. Good protein, omegas, B vitamins, acetylcarnitine, exercise, sleep, all of that still applies when we’re using these peptides. So I want to talk briefly about clinical decision and framework when we’re looking at this. First and foremost, we always want to go to FDA-approved peptides. Secondly, we would look at international approval with peptides that are established in other countries but lack FDA approval. And then preclinical evidence only or experimental peptides. These can be used, but they are not ethically recommended in the traditional medicine world. Dr. Deb Muth 54:50 If patients use them, we need to have appropriate counseling about the evidence surrounding them, the safety, and where to find them. how to find them and how to ask for these certificates of analysis. So I think it’s really good that we were exploring all these peptides and understanding what they are. There’s a lot of controversy out there. There’s a lot of concern out there. And what we can say with confidence is that peptides are powerful biological signaling molecules. Some peptide based medications, semi-glutide, triseptide, PT 141, Lupron that are all FDA approved. can dramatically improve outcomes in patients that are obviously selected for the correct ones. There are many other peptides that we address that are integrative and longevity space in the regenerative medicine. These peptides are all experimental. That does not automatically make them wrong. Dr. Deb Muth 55:50It just means that we need to be honest about what we’re doing with them and we need to be cautious with the patients so that they can make a decision to be part of an experimental study. in looking at how to use these peptides. So peptides are tools like any other tools. They work best in the hands of skilled people, and they are applied to appropriate situations, integrating into comprehensive approaches that address root causes. The most powerful peptide administered to a patient with untreated inflammation, hormonal chaos, nutritional deficiencies, and disorders of sleep will disappoint. The simplest evidence-based interventions apply. to a patient whose foundational physiology has been optimized. And this is the art of the science of peptide, right? If done right, respecting both the power of these molecules and the complexity of human beings that we are privileged to serve can make a difference in their lives. So thank you for listening to this episode. Dr. Deb Muth 56:52I hope this was helpful. If you can know of somebody that might benefit from this, please like, share, and subscribe. It means a lot to us. And I hope you join us for our next episode of Let’s Talk Wellness Now. Welcome to Let’s Talk Wellness Now, where we bring expert insights directly to you. Please note that the views and information shared by our guests are their own and do not necessarily reflect those of Let’s Talk Wellness Now, its management, or our partners. Each affiliate, sponsor, and partner is an independent entity with its own perspectives. Today’s content is provided for informational and educational purposes only and should not be considered specific advice, whether financial, medical, or legal. While we strive to present accurate and useful information, we cannot guarantee its completeness or relevance to your unique circumstances. We encourage you to consult with a qualified professional to address your individual needs. Dr. Deb Muth 57:54Your use of information from this broadcast is entirely at your own risk. By continuing to listen, you agree to indemnify and hold Let’s Talk Wellness Now and its associates harmless from any claims or damages arising from the use of this content. We may update this disclaimer at any time and changes will take effect immediately upon posting or broadcast. Thank you for tuning in. We hope you find this episode both insightful and thought-provoking. Listener discretion is advised.The post Episode 258 – Investigational Peptides: What's Promising, What's Hype & What You Must Know first appeared on Let's Talk Wellness Now.
Host Lara Conklin and DACC All-Star Alec Harrison shared hosting duties as they welcome Jessica Aquino into the studio. Jessica is the Manager of Financial Aid at DACC.
Welcome back to the Outdoor Adventure Series podcast! In this special episode, recorded at the Illinois Destinations Association Fall Meeting in Danville, IL, we're chatting with an all-star panel to spotlight the remarkable legacy of the NJCAA Division II Men's Basketball Tournament, which has been hosted in Danville for an impressive 33 consecutive years.You'll hear from Scott Eisenhower, who helps drive the tournament's success as a committee member; Mike Hulvey, media representative and national radio industry leader; Brian Hensgen, chair of the championship committee; and Tim Bunton, athletic director at Danville Area Community College. Together, they share how this iconic tournament has grown—from welcoming just eight teams in its early days to now hosting twenty—and why it serves as a powerful anchor for Danville's community spirit and economy.Discover behind-the-scenes stories, the tournament's impact on local youth and businesses, and how Danville has become a destination for basketball fans nationwide. Whether you're a sports enthusiast, a destination marketer, or simply someone who loves hearing about community-driven events, this episode highlights the lasting magic of sports and local collaboration. So get ready to dive into the energy and excitement of one of the country's longest-running junior college basketball championships!LEARN MORELearn more about Danville, IL local attractions and experiences by visiting the Danville Area Visitors Bureau website at https://www.visitdanvillearea.com/ or on these social sites:Facebook: https://www.facebook.com/danvillecvbInstagram: https://www.instagram.com/danvillecvb/ 2026 NJCAA Division II Men's Basketball Championships: https://www.visitdanvillearea.com/event/2026-njcaa-division-ii-mens-basketball-championships/Event Tags: Basketball, Championships, DACC, Division II, Men's, NJCAAWebsite: https://www.njcaa.org/championships/sports/mbkb/div2/indexNEXT STEPSVisit us at https://outdooradventureseries.com to like, comment, and share our episodes.KEYWORDSIllinois Destinations Association, Danville Area Visitors Bureau, Basketball, Championships, DACC, Division II, Men's, NJCAA, Outdoor Adventure Series, Podcast#IllinoisDestinationsAssociation #DanvilleAreaVisitorsBureau #NJCAA #Basketball #OutdoMy Favorite Podcast Tools: Production by Descript Hosting Buzzsprout Show Notes by Castmagic Website powered by Podpage Be a Podcast Guest by PodMatch
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The ZENERGY Podcast: Climate Leadership, Finance and Technology
Welcome to The Zenergy Podcast! Today, Karan sits down with Jason Hochman, Co-Founder and Executive Director at Direct Air Capture Coalition to discuss the genesis of DACC as well as what the early days of getting the company off the ground looked like and the four pillars they operate under. They dive into how to engage with policy makers and how the inflation reduction act and infrastructure bill assist in building up the direct air capture industry. Jason walks us through a few direct air capture projects to explain exactly how this process happens and shares why it's important we include direct air capture in our climate solution plans. Finally, Jason lets us in on the place that has had the biggest impact on his environmental perspective. If you haven't subscribed to the podcast yet, be sure to do so, and follow us on all the socials. New episodes go out every Thursday.Listen to The Zenergy Podcast: Spotify: https://open.spotify.com/show/5HEZXoEfuDa548Ty81gBWN Apple Podcasts: https://podcasts.apple.com/us/podcast/the-zenergy-podcast-climate-leadership-finance/id1556215421Follow The Zenergy Podcast on all the socials: X (Twitter): @TakharK2 Facebook: https://www.facebook.com/Znrg.org Instagram: @zen_rgy LinkedIn: ZNRG YouTube: ZNRG – The ZENERGY PodcastConnect with Jason: https://daccoalition.org/ Extantia Capital Article: "Will Direct Air Capture Ever Be Affordable? The Rise of DAC 3.0"Timestamps:0:00 - Intro 0:20 - Welcome 1:30 - What Jason would be doing if he never started DACC3:20 - Origin of DACC10:30 - The early days of DACC14:30 - What does it look like to participate in the coalition 17:45 - DACC's 4 strategic pillars25:05 - How legislation has helped DACC30:45 - Details on carbon removal projects37:50 - Targets for DACC technologies 42:50 - How the election outcome will impact DACC45:20 - Why some in the climate community are not supporters of DACC50:00 - Antarctica52:05 - The place that has had the biggest impact on JasonCredits:Editing/Graphics: Desta Wondirad, Wondir Studios
In this episode, we discuss the connections between autism and eye movements, starting with the underappreciated role of eyes in human biology. We emphasize the significance of the retina, which is central to both image-forming and non-image-forming functions of vision. The discussion takes a turn towards how blind individuals also leverage their eyes for biological functions beyond sight, highlighting the pervasive influence of visual systems on human physiology. We explore the superior colliculus, an essential brain region that integrates sensory information from various sources, including vision, to direct our attention and reflexive responses. This area is crucial in understanding how sensory input differently, particularly in terms of attention bias and threat detection, which could explain some of the unique sensory experiences in Autism.We then touch upon the dorsal anterior cingulate cortex (dACC) and the roles in error detection, conflict monitoring, and effort evaluation. The dACC's involvement in these cognitive processes can provide insights into why certain social cues or environmental stimuli might be overwhelming or less salient for individuals on the spectrum. Additionally, the episode covers oxytocin, a hormone/neuropeptide involved in social bonding and emotional regulation, discussing its synthesis through magnocellular and parvocellular pathways in vision. What do you think oxytocin is doing here, for the cub and for you? https://www.reddit.com/r/NatureIsFuckingLit/comments/11q03yn/a_cub_puma_admiring_his_mother/?rdt=64743Eye-Tracking as an Early Biomarker of Autism https://youtu.be/fJpIRHOZZO4The Roles of Oxytocin and Vasopressin in the Autistic phenotype https://youtu.be/DAtmC-s1_e0Mesencephalon https://en.wikipedia.org/wiki/Midbrain#:~:text=The%20midbrain%20or%20mesencephalon%20is,view%20of%20one%20cerebellar%20hemisphere.00:00 - Introduction to Autism and Eye Movements; importance of eyes in biology, specifically mentioning the retina as a key player.04:19 - Non-Image Functions and Master Clock; Melanopsin; SCN- master clock08:13 - Eye Tracking and Autism Diagnosis; effectiveness at 14 months of age12:23 - Biological Underpinnings of Eye Movements in Autism; dorsal anterior cingulate cortex (dACC), Superior Colliculus & Mesencephalon & sensory integration, attention in the context of Autism & brain development16:48 - Sensory Integration & Superior Colliculus and Reflexive Responses & Biasing Attention.20:58 - Developmental Aspects of Autism; embryonic stage before the central nervous system25:11 - Vision and Autonomic Nervous Systemvision and breathing can influence stress and calmness & bidirectional connections27:47 Reviews/Ratings and Contact InformationX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com
Reimagining Justice: Exploring Texas Innovations in Mental Health
In this episode, we are joined by Yvonne Mboss, a Clinical Case Manager Supervisor, and Jennifer Sowinski, a Clinical Operations Manager, of the Downtown Austin Community Court. They tell us about DACC, a problem-solving court established in 1999, and its different programs. The mission of DACC is to empower people to thrive by providing impartial justice and compassionate community-based services. If you have an innovation in mental health that you'd like to see on the podcast, email JCMH@txcourts.gov with the subject line "Reimagining Justice." *Disclaimer: The views, thoughts, and opinions expressed are the speaker's own and do not represent the views, thoughts, and opinions of the JCMH, the Supreme Court of Texas, or the Texas Court of Criminal Appeals. The material and information presented here are for general information purposes only.
What is the future of dehumidification? Turns out this simple question opens up an exciting view of the future of IAQ generally. The goal of a low energy method for removing water molecules from a flowing airstream boils down to some way of identifying, grabbing and holding onto them. Essentially we are talking about a designer desiccant or molecular filter that lets the air pass through while it filters out water molecules. If we can do this, the next logical question is “Why stop there?” Why not identify a broad range of pollutants and contaminants in the airstream and also select and remove them as well? Enter metal molecularly sensitive filtration based on Metal Oxide Framework (MOF) technology. MOFs are a type of advanced material that scientists are developing to tackle a wide range of challenges, from clean energy, to environmental protection via direct air carbon capture (DACC), to health and drug delivery.. While the name may sound complex, the basic idea behind MOFs is relatively simple—they are materials made by combining metal ions (like zinc, iron, or copper) with organic molecules to create a kind of 3D structure that is highly porous, meaning it has lots of tiny holes or cavities - and they operate as a molecular sieve or filter. Join Kristof as he interviews Todd DeMonte of Madison IAQ to unpack the future of dehumidification and learn about desiccants, and the potential for metal oxide frameworks. Along the way we learn whether the “good old” compressor-based dehumidifier is likely to remain the preferred and appropriate approach for many years to come. This is an episode that will bring you up to date at this important edge of the industry. Enjoy!Important Links!Article on MOFs:https://pubs.acs.org/doi/10.1021/jacs.7b04132SMECO Document discussing 3Å wheels:https://www.semcohvac.com/hubfs/Importance_of_3A_Molecular_Sieve.pdf?hsLang=enLithium Chloride Examples:https://www.alfalaval.us/products/heat-transfer/dehumidification/liquid-desiccant-dehumidification/https://temaprocess.com/products/dehumidifier/https://www.ventilex.com/working-principle-drygenic-air-dehumidification/Todd DemonteTodd DeMonte is the Chief Innovation Officer of Madison Indoor Air Quality (MIAQ), a Madison Industries business vertical that holds the following companies: Nortek, Broan-NuTone, StatePoint, NGH, Big Ass Fans, UV-Resources, Therma-Stor, DAS, Addison, Specified Air, Air Xchange, Novel Aire, United Cool Air, Conviron, Argus Controls, and Steril-Aire. As Chief Innovation Officer, Todd identifies and leads the development of innovative new product concepts, markets, and solutions across all MIAQ companies, increasing vitality and driving long-term value creation.Prior, Todd was President and General Manager of Therma-Stor from 2004-2019, where he and his team grew the company's revenue over 600% ($100M+) and created over $250M in enterprise value through innovation in products and markets.Before joining Therma-Stor, Todd was a business owner and worked as a manager and technician in the automotive business for more than 10 years. During that time, he won awards from Mercedes-Benz, Land Rover and for being among the top 15 and top 10 (respectively) technicians in the United States.Todd earned a B.S. in Mechanical Engineering from Cornell University and an M.B.A. from Tulane University. He has been awarded 28 U.S. patents with several more pending.TeamHosted by Kristof IrwinEdited by Nico MignardiProduced by M. Walker
Welcome to The Coaches Zone! In this episode, Ramon, founder of BrainFirst, explores the topic of enhancing decision-making through cognitive flexibility, based on insights from his book, "The Handbook of Professional Coaching Competencies." This episode is packed with neuroscience and psychology insights, case studies, and practical takeaways that are invaluable for coaches and professionals alike. www.professionalcoachingcompetencies.com BrainFirst Institute: https://www.brainfirstinstitute.com Connect with me: https://www.linkedin.com/in/ramondavidmsc/ Key Topics Covered The Neuroscience of Decision-Making: Understanding how the prefrontal cortex and the limbic system influence our choices, and how emotional responses and memories play a significant role. Enhancing Cognitive Flexibility: Techniques to improve mental agility, allowing individuals to consider multiple perspectives and outcomes effectively. Emotional Regulation Techniques: Methods like mindfulness meditation and deep breathing to manage stress and approach decisions with clarity. Decision-Making Exercises: Practical activities such as scenario planning and pros and cons lists to strengthen decision-making skills. Reflective Journaling: Using journaling to explore how emotions and past experiences influence decisions, increasing self-awareness and conscious choice-making. Case Study: Jane's Journey with Coach Alex Jane, a mid-career professional, sought guidance from Coach Alex to navigate a significant career transition. Despite her successful track record in corporate finance, she felt unfulfilled and was considering a shift to the non-profit sector. Coach Alex employed various techniques to help Jane enhance her cognitive flexibility and emotional regulation, leading her to a well-informed decision to pursue a Master's in Public Administration while maintaining her current role. Key Techniques Used Scenario Planning: Envisioning different career paths and evaluating their outcomes. Role-Playing Exercises: Articulating and defending decisions in hypothetical scenarios. Mindfulness Meditation: Managing anxiety and stress related to career changes. Practical Takeaways for Coaches Enhancing Cognitive Flexibility: Encourage clients to engage in brain games, puzzles, and learning new skills to strengthen the prefrontal cortex. Emotional Regulation Techniques: Teach mindfulness meditation and deep breathing to help clients manage their emotions and approach decisions with a clear mind. Decision-Making Exercises: Implement structured exercises like pros and cons lists or scenario planning to train the dorsal anterior cingulate cortex (dACC). Reflective Journaling: Promote journaling to help clients explore how their emotions and past experiences influence their decision-making. Conclusion Incorporating these strategies into your coaching practice can significantly enhance your clients' decision-making abilities. By fostering cognitive flexibility, emotional regulation, structured decision-making, and reflective journaling, you empower your clients to navigate complex decisions with greater clarity and confidence. For more neuroscience-based resources and education for coaches, visit www.brainfirstinstitute.com. Don't forget to subscribe and leave a review if you enjoyed this episode of The Coaches Zone. Catch you in the next episode!
Zes ‘Dutch Houses' in Brisbane zijn genomineerd voor erfgoedbescherming. Het Dutch Australian Cultural Centre (DACC) bracht een aantal jaar geleden de geschiedenis van deze huizen onder de aandacht van de lokale gemeenschap. Als gevolg hiervan heeft de lokale geschiedenisgroep een verzoek ingediend om de huizen te beschermen. Met Paul Budde van de DACC praten we over dit goede nieuws.
Guido came from Chicago, IL moved to Champaign IL and stayed, this is where he connected with his now music family. Guido. wears many hats, Bass Player/ Bass Player in 90's Daughter (Party Band), First Gig Rock n Roll Camp for kids leader/teacher/part of the founding structures of FGRRCFK. Music Director for Rod Sickler's Red Hot Winter, and Works at Danville Area Community College, currently has put together a band with the kids form DACC called "Project M". and has also written original music which is currently being recorded at High Cross Studio. LINKS: https://www.facebook.com/90sDaughterDanville Area Community College: https://dacc.eduhttps://www.facebook.com/events/2240936552835872https://firstgigrockcamp.comhttps://www.facebook.com/livekaraokebandCURed Hot Winter: https://redhotwinter.comSave the date March 29th for Guido's 50th bday jam at the Cowboy Monkey! Feat: Temple of Low Men, Curb Service, Brandon T., Tom Grassman Band, 90s Daughter, Mike Ingram, Brother Embassy, THE BRAT PACK proceeds and donations will go to Ian Shepherd (Drummer, band mate) of 90's Daughter to offset Medical expenses due to his very recent diagnosis of cancer.HOME GROWN KIO Sunday Nights at 7pm HOME GROW KIO (Classic Rock WKIO 107.9 FM) A stellar show featuring the great songs that have comDisclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showFind us on Social Media Facebook: https://www.facebook.com/CuBandsandFansInstagram: https://www.instagram.com/cubaf2018/Website: https://cubandsfan4.wixsite.com/cubandsandfansPodcast are on our web site CU Bands and Fans "Where Musicians Tell Their Story" Podcast Group https://www.facebook.com/groups/695230782250029Home Grown KIO Group on Facebook: https://www.facebook.com/groups/876171327104082Classic Hits WKIO ( Home Grown KIO Show Sunday's at 7pm)https://www.news-gazette.com/wkio/CI Direct Connect https://www.cidirectconnect.com/
This audio article suggests that Defence Assistance to the Civil Community should be seen not just as a duty and opportunity to help the nation, but also as an opportunity to improve Defence itself.
Girl Scouts donate to U of I vet clinic, DACC grant aims to boost EV training, and new Illinois university admissions law. Hosted by Emily HuffmanStories by Joaquim O'Malley-Macias, Adelyn Mui, and Kate Morris. Music by Outbox
Het bestuur van de Dutch Australian Cultural Centre is met een gemiddelde leeftijd van 80 jaar zwaar vergrijsd. Om ervoor te zorgen dat de club (opgericht in 1983) nog tientallen jaren mee kan is men dringend op zoek naar nieuwe vrijwilligers voor uiteenlopende taken. We belden met voorzitter Paul Budde.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.30.547251v1?rss=1 Authors: Strohman, A., Payne, B., In, A., Stebbins, K., Legon, W. Abstract: Homeostasis is the process of maintaining physiologic balance in the body that is critical for maintaining health and is dysfunctional in several disorders like chronic pain. The dorsal anterior cingulate cortex (dACC) is a critical brain area for homeostatic cardiovascular responses and pain processing, making it a promising non-invasive therapeutic target. We leverage the high spatial resolution and deep focal lengths of low-intensity focused ultrasound (LIFU) to non-invasively modulate the dACC for an effect on behavioral and cardiac autonomic responses using a transient heat pain stimulus. N = 16 healthy human volunteers (6M/10F) received transient contact heat pain during either LIFU to the dACC or Sham stimulation. Continuous electroencephalogram (EEG), electrocardiogram (ECG), and electrodermal response (EDR) were recorded. Outcome measures included perceived pain ratings, homeostatic measures including heart-rate variability, blood pressure, EDR response as well as the amplitude of the contact heat-evoked potential (CHEP). LIFU reduced pain ratings by 1.08 {+/-} 0.21 points relative to Sham. LIFU increased heart rate variability indexed by the standard deviation of normal sinus beats (SDNN), low frequency (LF) power, and the low-frequency/high-frequency (LF/HF) ratio. There were no effects on blood pressure or EDR. LIFU resulted in a 25.1% reduction in the N1-P1 CHEP amplitude driven primarily by effects on the P1 amplitude. Our results demonstrate LIFU to the dACC reduces perceived pain and alters homeostatic cardiovascular responses to a transient heat pain stimulus. These results have implications for the causal understanding of human pain and autonomic processing in the dACC and the potential for future therapeutics for pain relief and homeostatic modulation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
In this audio article, LT Price shares lessons from Operation Flood Assist 22: from logistics to empowering your subordinates with key information.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.03.531040v1?rss=1 Authors: Kuehnel, A., Hagenberg, J., Knauer-Arloth, J., Koedel, M., Czisch, M., Saemann, P. G., BeCOME Working Group,, Binder, E. B., Kroemer, N. B. Abstract: Background: Stress is associated with elevated risk for overweight and obesity, especially in women. Since body mass index (BMI) is correlated with increased inflammation and reduced baseline cortisol, obesity may lead to altered stress responses. However, it is not well understood whether stress-induced changes in brain function scale with BMI and if peripheral inflammation contributes to this. Methods: We investigated the subjective, autonomous, endocrine, and neural stress response in a transdiagnostic sample (N=192, 120 women, MBMI=23.7+/-4.0 kg/m2; N=148, 89 women, with cytokines). First, we used regression models to examine effects of BMI on stress reactivity. Second, we predicted BMI based on stress-induced changes in activation and connectivity using cross-validated elastic-nets. Third, to link stress responses with inflammation, we quantified the association of BMI-related cytokines with model predictions. Results: BMI was associated with higher negative affect after stress and an increased response to stress in the substantia nigra and the bilateral posterior insula (pFWE less than .05). Moreover, stress-induced changes in activation of the hippocampus, dACC, and posterior insula predicted BMI in women (pperm less than .001), but not in men. BMI was associated with higher baseline cortisol while cytokines were not associated with predicted BMI scores. Conclusions: Stress-induced changes in the hippocampus and posterior insula predicted BMI in women, indicating that acute brain responses to stress might be more strongly related to a higher BMI in women compared to men. Altered stress-induced changes were associated with baseline cortisol but independent of cytokines, suggesting that the endocrine system and not inflammation contributes to stress-related changes in BMI. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.28.530543v1?rss=1 Authors: Lee, H., Lee, S.-H. Abstract: Boundary-updating, a process of updating decision boundaries, has been known to induce a history effect on binary choices. However, the history effect that boundary-updating has on decision uncertainty has been previously overlooked. Our study revealed that boundary-updating can also impact decision uncertainty, as evidenced by changes in response time, pupil-size, and dACC response, suggesting that boundary-updating is a source of history effect not only on choice but also decision uncertainty. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.25.529925v1?rss=1 Authors: Jhang, J., Liu, S., O'Keefe, D. D., Han, S. Abstract: Breathing is profoundly influenced by both behavior and emotion and is the only physiological parameter that can be volitionally controlled. This indicates the presence of cortical-to-brainstem pathways that directly control brainstem breathing centers, but the neural circuit mechanisms of top-down breathing control remain poorly understood. Here, we identify neurons in the dorsal anterior cingulate cortex (dACC) that project to the pontine reticular nucleus caudalis (PnC) and function to slow breathing rates. Optogenetic activation of this corticopontine pathway (dACC[->]PnC neurons) in mice slows breathing and alleviates behaviors associated with negative emotions without altering valence. Calcium responses of dACC[->]PnC neurons are tightly correlated with changes in breathing patterns entrained by behaviors, such as drinking. Activity is also elevated when mice find relief from an anxiety-provoking environment and slow their breathing pattern. Further, GABAergic inhibitory neurons within the PnC that receive direct input from dACC neurons decrease breathing rate by projecting to pontomedullary breathing centers. They also send collateral projections to anxiety-related structures in the forebrain, thus comprising a neural network that modulates breathing and negative affect in parallel. These analyses greatly expand our understanding of top-down breathing control and reveal circuit-based mechanisms by which slow breathing and anxiety relief are regulated together. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
(Airdate 2/16/23) Marcia Mayeda has served as Los Angeles County's Director of Animal Care and Control (DACC) since July, 2001. DACC provides animal care and control services for all unincorporated Los Angeles County and the 45 cities that contract with DACC for services. In this profession since 1984, Marcia is a Certified Animal Welfare Administrator. The department has community resource centers for pets, with care vouchers, a pet food bank, care vouchers, temporary pet boarding for those experiencing homelessness or entering rehab and much more. www.animalcare.lacounty.gov
Paul Budde is een bekende naam binnen de Nederlandse community in Australië. Zo is hij betrokken bij DutchLink in Brisbane en zet hij zich in voor de DACC. Bij het doorspitten van het archief van de Dutch Australian Cultural Centre stuit hij soms op gebeurtenissen waar weinig mensen van gehoord hebben en nog maar weinig van bekend is. Zoals het verhaal van de vermoorde Dungong (zeekoe) visser uit Nederland in 1859, in de buurt van Brisbane.
Parenzo: "La Meloni sta facendo bene". Eccallà. Cruciani, invece, si dichiara favorevole ai combustibili fossili davanti alle dichiarazioni di Ultima Generazione. Simone da Ancona denunzia la presenza dei poteri forti dietro alle scelte ecologiche. Se ne è andato Roberto Digiovandomenico, l'apostolo che ne incarnava due. Un momento triste. Marco, amico di Daccò, vuole parlare del Re dei Re e dà dei satanisti ai conduttori. Torna Rocco Carlomagno, per fortuna non si sente. Il direttorissimo Vittorio Feltri è caldissimo. Se trovasse uno di quelli ambientalisti sdraiati lui consiglierebbe di "procedere". L'emergenza climatica? Una boiata. La benzina? Non sa neanche come si fa. E poi... "dove mandare a pregare i musulmani? Se ne vadano a fare in c**o" Marco Mazzei è il consigliere che ha proposto la Zona 30 per tutta Milano. Non hal'auto e sta in centro. In studio Bennygreen si racconta. Porno e anche Onlyfans. Lei schiaccia la frutta. Poi arriva Annarita Briganti ed è scontro.
Bon dia i benvinguts a la Plaça, el vostre programa de proximitat de Baix Camp Ràdio. Com cada dia arranquem donant un tomb per la nostra estimada comarca per a conèixer una mica més sobre la seva gent i explicar-vos les últimes novetats. Avui en el nostre particular passeig el que fem és fer una […] L'entrada Glòria Tibau, nova directora dels serveis territorials del DACC a Tarragona ha aparegut primer a BXC Ràdio Ciutat de Reus - Ràdio Online.
Ràdio Ciutat de Tarragona | Tots els continguts rctgn.cat Radio
Bon dia i benvinguts a la Plaça, el vostre programa de proximitat de Baix Camp Ràdio. Com cada dia arranquem donant un tomb per la nostra estimada comarca per a conèixer una mica més sobre la seva gent i explicar-vos les últimes novetats. Avui en el nostre particular passeig el que fem és fer una […] L'entrada Glòria Tibau, nova directora dels serveis territorials del DACC a Tarragona ha aparegut primer a BXC Ràdio Ciutat de Reus - Ràdio Online.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.01.518771v1?rss=1 Authors: Ritz, H., Shenhav, A. Abstract: People can overcome a wide array of mental challenges by coordinating their neural information processing to align with their goals. Recent behavioral work has shown that people can independently control their attention across multiple features during perceptual decision-making, but the structure of the neural representations that enables this multivariate control remains mysterious. We hypothesized that the brain solves this complex coordination problem by orthogonalizing feature-specific representations of task demands and attentional priority, allowing the brain to independently monitor and adjust multiple streams of stimulus information. To test this hypothesis, we measured fMRI activity while participants performed a task designed to tag processing and control over feature-specific information that is task-relevant (targets) versus task-irrelevant (distractors). We then characterized the geometry of these neural representations using a novel multivariate analysis (Encoding Geometry Analysis), estimating where the encoding of different task features is correlated versus orthogonal. We identified feature-specific representations of task demands and attentional priority in the dorsal anterior cingulate cortex (dACC) and intraparietal sulcus (IPS), respectively, consistent with differential roles for these regions in monitoring versus directing information processing. Representations of attentional priority in IPS were fully mediated by the control requirements of the task, associated with behavioral performance, and depended on connectivity with nodes in the frontoparietal control network, suggesting that these representations serve a fundamental role in supporting attentional control. Together, these findings provide evidence for a neural geometry that can enable coordinated control over multiple sources of information. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.02.514527v1?rss=1 Authors: liang, y., zhao, q., Hu, Z., Bo, K., Meyyappan, S., Neubert, J., Ding, M. Abstract: Trigeminal neuralgia (TN) is a severe and disabling facial pain condition and is characterized by intermittent, severe, electric shock-like pain in one (or more) trigeminal subdivisions. This pain can be triggered by an innocuous stimulus or can be spontaneous. Presently available therapies for TN include both surgical and pharmacological management; however, the lack of a known etiology for TN contributes to the unpredictable response to treatment and the variability in long-term clinical outcomes. Given this, a range of peripheral and central mechanisms underlying TN pain remain to be understood. We acquired functional magnetic resonance imaging (fMRI) data from TN patients who (1) rested comfortably in the scanner during a resting state session and (2) rated their pain levels in real time using a calibrated tracking ball-controlled scale in a pain tracking session. Following data acquisition, the data was analyzed using the conventional correlation analysis and two artificial intelligence (AI)-inspired deep learning methods: convolutional neural network (CNN) and graph convolutional neural network (GCNN). Each of the three methods yielded a set of brain regions related to the generation and perception of pain in TN. There were six regions that were identified by all three methods, including the superior temporal cortex, the insula, the fusiform, the precentral gyrus, the superior frontal gyrus, and the supramarginal gyrus. Additionally, 17 regions, including dorsal anterior cingulate cortex(dACC) and the thalamus, were identified by at least two of the three methods. Collectively, these 23 regions represent signature centers of TN pain and provide target areas for future studies relating to central mechanisms of TN. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.28.513278v1?rss=1 Authors: da Silva Castanheira, K., Spreng, N., Vassena, E., Otto, A. R. Abstract: Prominent theories of cognitive effort-based decision-making posit that shared brain regions process both potential reward and task demand, supporting the idea that effort allocation are informed by a cost-benefit trade-off, weighing the expected benefits of successful control against the inherent costs of effort exertion. While the dorsal anterior cingulate cortex (dACC) has been proposed as a candidate region supporting this decision, it remains unclear whether dACC activity tracks rewards and costs as independent quantities, or it reflects the effort intensity worth the integrated costs and benefits. While recent accounts of dACC function posit a crucial role the region in negotiating cost-benefit trade-offs, empirical evidence for this account remains scarce across single studies. To address this, we conducted a systematic meta-analysis review of neuroimaging studies, using activation-likelihood estimation method to quantify brain activity across 45 studies (N = 1273 participants) investigating reward-guided effort. We found reliable recruitment of the dACC, putamen, and anterior insula for processing both larger rewards and increasing task demands. However, the dACC clusters sensitive to task demands and rewards were anatomically distinct with no significant overlap: caudal dACC activity tracked increasing task demands, while rostral dACC activity tracked increasing rewards. Critically, we also observed that caudal dACC activity tracked the integration of costs and benefits, compatible with mental effort intensity account. These findings suggest there are distinct signals for demand and effort in the dACC which are also integrated to support the decision to invest effort, supporting recent computational accounts of cost-benefit value integration in effort-based choice. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Welcome to Devon Aire Community Church! Here are some updates that will be helpful. We will begin posting weekly devotionals based on the current sermon series. Follow up here: DACC Facebook page Devon Aire Kids Facebook page Instagram page @devonairecommunity Sign up to be added to our Events email list here www.dacclivonia.com
Aníbal Luna - Presidente de la Agrupación de Productores del Oasis Sur (POS). Acuerdo que se estableció entre productores, la DACC y la Subsecretaría de Agricultura por el RUT
The Dutch Australian Cultural Centre heeft een gigantisch rijk archief. In dit archief zijn ook kopieën van tientallen historische wereldkaarten te vinden. Roland Spuij, voorzitter van de DACC, vertelt over de kaarten die de Nederlandse ontdekkingsreizigers gebruikten.
De Dutch Australian Cultural Centre bestaat al 38 jaar en is in het bezit van een gigantisch archief met daarin oude programmaboekjes, posters, foto's, landkaarten en gehele administraties van Nederlandse verenigingen in Australië die inmiddels niet meer bestaan. Sommige documenten zijn meer dan 100 jaar oud. Dat fysieke archief gaat in 2022 gedigitaliseerd worden. Ik sprak er over met de voorzitter van de DACC, Roland Spuij.
DACCCAST is back with an all-new season! In our third episode of the season, our new hosts, Erin and Landon, take a dive into the background of DACC's very own Alexis Simmons.
DACCCAST is back with an all-new season! In our first episode of the season, our new hosts, Erin and Landon, take a dive into the background of DACC's Keith Miller.
Hot 103 Graduation NMSU/DACC by Mesilla Valley News
In this final episode of a two part series we meet with Michelle York, a spiritual messenger, where she breaks down what exactly a psychic and a medium do and how exactly she practices. From there, buckle in as she walks through the DACC campus and tells us exactly what she's experiencing. We promise, you wont want to miss this one!
DACCCAST is a student-produced podcast. In this episode, Kia & Keegan dive deep into what options DACC provides in the automotive industry while getting to know one of the faculty members behind it! Strap-in in this week as Alan Wilson shares about the Freedom Scholarship in his son's honor, important life skills to have in the automotive industry, and why he loves Danville so much!
DACCCAST is a student-produced podcast. On this episode Kia & Keegan have the pleasure of catching up with DACC's Athletic Director, Tim Bunton. Tune in to hear about what it takes to start a sport from the ground up at a college and just how Tim pulled it off. Such a fun and interesting episode you won't want to miss!
DACCCAST is a student-produced podcast. In this episode, Kia & Keegan learn just how many scholarship options DACC has available- spoiler alert! A LOT! Tonya is such an influential figure not only here at DACC but in the Danville community. We are so lucky to have her and we think you'll know why after you listen to this episode!
DACCCAST is a student-produced podcast. In this episode, Kia & Keegan sit down with our very own Office Specialist in the Admissions & Records office, Mary Jo Gentrup. Tune in to this light-hearted episode where we learn more about this DACC alum, mother, small business owner, and an all-around great person.
DACCCAST is a student-produced podcast. On this episode of DACCCAST Kia & Keegan sit down with DACC's student services vice president Stacy Ehmen. Get ready, on this episode of DACCCAST we learn how Stacy got into her position to how adopting her son from Russia changed her life. Here is your fresh scoop of DACCCAST.
DACCCAST is a student-produced podcast. On this episode of DACCCAST our host Kia & Keegan focus on getting to know Dr. Jonathan Wade and how he came to DACC to teach as a behavioral science instructor. This episode dives into the world of psychology and sociology and also tells a story of someone finding themselves.
A student produced podcast diving into the background and history of DACC's president Dr. Stephen D. Nacco.
Here on DACCCAST, we get to know the familiar faces we see all over campus in hopes that students at DACC and members of the community get to know each other a little better.
A student produced podcast diving into the background and history of DACC's very own Laura Hensgen.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.21.348649v1?rss=1 Authors: Gilbertson, H., Fang, L., Andrzejewski, J., Carlson, J. M. Abstract: The error-related negativity (ERN) is a response-locked event-related potential, occurring approximately 50 ms following an erroneous response at frontocentral electrode sites. Source localization and functional magnetic resonance imaging (fMRI) research indicate that the ERN is likely generated by activity in the dorsal anterior cingulate cortex (dACC). The dACC is thought to be a part of a broader network of brain regions that collectively comprise an error-monitoring network. However, little is known about how intrinsic connectivity within the dACC-based error-monitoring network contributes to variability in ERN amplitude. The purpose of this study was to assess the relationship between dACC functional connectivity and ERN amplitude. In a sample of 53 highly trait-anxious individuals, the ERN was elicited in a flanker task and functional connectivity was assessed in a 10-minute resting-state fMRI scan. Results suggest that the strength of dACC seeded functional connectivity with the supplementary motor area is correlated with the dERN (i.e., incorrect - correct responses) amplitude such that greater dERN amplitude was accompanied by greater functional coupling between these regions. In addition to the dACC, exploratory analyses found that functional connectivity in the caudate, cerebellum, and a number of regions in the error-monitoring network were linked to variability in dERN amplitude. In sum, ERN amplitude appears to be related to the strength of functional connectivity between error-monitoring and motor control regions of the brain. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.20.305482v1?rss=1 Authors: Yee, D. M., Crawford, J. L., Braver, T. S. Abstract: Humans can seamlessly combine value signals from diverse motivational incentives, yet it is not well-understood how these signals are 'bundled' in the brain to modulate cognitive control. The dorsal anterior cingulate cortex (dACC) is theorized to integrate motivational value dimensions in the service of goal-directed action, though this hypothesis has yet to receive rigorous confirmation. Here, we examine the role of dACC in motivational integration using an experimental paradigm that quantifies combined effects of liquid (e.g., juice, neutral, saltwater) and monetary incentives on cognitive task performance. These incentives modulated dACC activity in both a trial-by-trial and block-wise fashion. Incentive-related dACC modulation predicted fluctuations in cognitive performance and self-report motivation ratings. Statistical mediation analyses indicate that dACC encodes incentives in terms of subjective motivational value, and that this value signal is associated with task performance. These results suggest dACC integrates motivational signals to compute the expected value of goal-directed cognitive control. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.16.300525v1?rss=1 Authors: Aberg, K. C., Toren, I., Paz, R. Abstract: Exploration reduces uncertainty about the environment and improves the quality of future decisions, but at the cost of uncertain and suboptimal outcomes. Although anxiety increases intolerance to uncertainty, it remains unclear whether and how anxiety modulates exploratory decision-making. We use a three-armed-bandit task in both loss and gain domains and find that higher trait-anxiety increases exploration, which in turn underlies an inverse-U-shaped relationship between anxiety and overall performance. We identify two distinct sources: first, decisions made by anxious individuals were guided towards reduction of uncertainty, and second, decisions were less guided by immediate value gains. Imaging (fMRI) revealed that anxiety correlated negatively with the representation of expected-value in the dorsal-anterior-cingulate-cortex, and in contrast positively with the representation of uncertainty in the anterior-insula. We conclude that a shift in balance towards representation of uncertainty in the insula prevails over value representation in the dACC, and entails maladaptive decision-making in individuals with higher normal-range anxiety. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.08.283671v1?rss=1 Authors: Bush, K. A., James, G. A., Privratsky, A. A., Fialkowski, K. P., Kilts, C. D. Abstract: In this study, we merged methods from engineering control theory, machine learning, and human neuroimaging to critically test the putative role of the dorsal anterior cingulate cortex (dACC) in performance monitoring during an emotion regulation task. Healthy adult participants (n=75) underwent cued-recall of affective image stimuli with concurrent functional magnetic resonance imaging and psychophysiological response recording. During cued-recall, participants engaged in explicit self-regulation of their affective state toward defined affective goals. Established decoding methods measured affect processing from fMRI BOLD signals across the orthogonal affective dimensions of valence and arousal. We independently validated participants' affective state representations via stimulus-dependent facial electromyography (valence) and electrodermal activity (arousal) responses. We then used the decoded affective signatures to test and compare four computational models of performance monitoring (i.e., error, predicted response outcome, action-value, and conflict) by their relative abilities to explain task-related dACC activation. We found that the dACC most plausibly encodes action-value for both valence and arousal processing. We confirmed that the dACC directly encodes affective arousal and also likely encodes recruitment of attention and regulation resources. Beyond its contribution to parsing the roles of the dACC in emotion regulation, this study introduced a novel analytical framework through which affect processing and regulation may be functionally dissociated, thereby permitting mechanistic analysis of real-world emotion regulation strategies, e.g., distraction and reappraisal, which are widely employed in cognitive behavioral therapy to address clinical deficits in emotion regulation. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.03.275479v1?rss=1 Authors: Newbold, D. J., Gordon, E. M., Laumann, T. O., Montez, D. F., Seider, N. A., Gross, S. J., Zheng, A., Nielsen, A. N., Hoyt, C. R., Hampton, J. M., Ortega, M., Adeyemo, B., Miller, D. B., Van, A. N., Marek, S., Schlaggar, B. L., Carter, A. R., Kay, B. P., Greene, D. J., Raichle, M. E., Petersen, S. E., Snyder, A. Z., Dosenbach, N. U. F. Abstract: Two weeks of upper extremity casting induced plasticity beyond somatomotor regions. Whole-brain resting-state functional MRI (rs-fMRI) revealed that disused motor regions became more strongly connected to the cingulo-opercular network (CON), an executive control network that includes regions of the dorsal anterior cingulate cortex (dACC) and insula. Disuse-driven increases in functional connectivity (FC) were specific to the CON and somatomotor networks and did not involve any other networks, such as the salience, frontoparietal or default mode networks. FC increases during casting were mediated by large, spontaneous activity pulses that appeared in disused motor regions and network-adjacent CON control regions. During limb constraint, disused motor circuits appear to enter a standby mode characterized by spontaneous activity pulses and strengthened connectivity to CON executive control regions. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.31.123380v1?rss=1 Authors: Wang, M. Z., Hayden, B. Abstract: Curiosity refers to a desire for information that is not driven by immediate strategic or instrumental concerns. Latent earning refers to a form of learning that is not directly driven by standard reinforcement learning processes. We propose that curiosity serves the purpose of motivating latent learning. Thus, while latent learning is often treated as an incidental or passive process, in practice it most often reflects a strong evolved pressure to consume large amounts of information. That large volume of information in turn allows curious decision makers to generate sophisticated representations of the structure of their environment, known as cognitive maps. Cognitive maps facilitate adaptive and flexible behavior while maintaining its adaptivity and flexibility via map updates based on new information. Here we describe data supporting the idea that orbitofrontal cortex (OFC) and dorsal anterior cingulate cortex (dACC) play complementary roles in curiosity-driven learning. Specifically, we propose that (1) OFC tracks the innate value of information and incorporates new information into a detailed cognitive map; and (2) dACC tracks the environmental demands and information availability to then use the cognitive map for guiding behavior. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.25.115139v1?rss=1 Authors: Wang, M., Hayden, B. Abstract: Disparity between current and desired information, known as information gap, is an important driver of information-seeking and curiosity. To gain insight into its neural basis, we recorded responses of single neurons in dorsal anterior cingulate cortex (dACC) while rhesus macaques performed a task that induces and quantifies demand for information. We find that enhanced firing rates in dACC before the start of a trial predict a stronger bias towards information-seeking choices. Following choices of uninformative options, firing rates are tonically enhanced until information is delivered. The level of enhancement observed is correlated on a trial-by-trial basis with the value assigned to the prospective information. Finally, variation in this tone is positively correlated with receptiveness to new information, as inferred by preference changes on subsequent trials. These patterns are not observed in a complementary dataset collected in orbitofrontal cortex (OFC), suggesting these effects reflect at least somewhat anatomically localized processing. Copy rights belong to original authors. Visit the link for more info
Trailer: Curiosity, an overview. Is curiosity an emotion? What are emotions anyway? Main Episode: Curiosity and Intrinsic Motivation. The feeling of curiosity may be similar to intrinsic motivation - an internal drive to explore, learn, practice and improve skills. We may have more intrinsic motivation or curiosity about something when we have two things: competence - the challenge is reasonably matched to our current skill level - it would be achievable with some effort, and autonomy - freedom to try without severe risks linked to any potential mistakes. Extrinsic motivation is an external force encouraging or coercing action - a school grade or job bonus is linked to the effort. Being allowed to be curious may help children and adults to achieve better success with grades, decisions, and even long term mental health. Bonus Episode: Curiosity Types and UX Design. UX Design focuses on improving user experience by planning user expectations and habits into software or product design. Curiosity types may help with design focused on what type of curiosity is motivating the consumer to seek out the product or website. Image Quote: "You love challenge." - a fortune from a Fortune Cookie Email - jen@peace-is-happy.org Twitter - @denutrients Webpage - peace-is-happy.org/how are you feeling Transcript/Reference list How Are You Feeling? episode: Perseverance and Self Control - the dACC. The dACC part of the brain, the dorsal Anterior Cingulate Cortex, may be a center for processing input from other areas of the brain that have to do with current physical sensations, thoughts, and emotional feelings.
Bonus: UX Design focuses on improving user experience by planning user expectations and habits into software or product design. Curiosity types may help with design focused on what type of curiosity is motivating the consumer to seek out the product or website. Main: Curiosity and Intrinsic Motivation. The feeling of curiosity may be similar to intrinsic motivation - an internal drive to explore, learn, practice and improve skills. We may have more intrinsic motivation or curiosity about something when we have two things: competence - the challenge is reasonably matched to our current skill level - it would be achievable with some effort, and autonomy - freedom to try without severe risks linked to any potential mistakes. Extrinsic motivation is an external force encouraging or coercing action - a school grade or job bonus is linked to the effort. Being allowed to be curious may help children and adults to achieve better success with grades, decisions, and even long term mental health. Trailer: Curiosity, an overview. Image Quote: "Climb mountains not so the world can see you, but so you can see the world." - David McCullough Jr. Email - jen@peace-is-happy.org Twitter - @denutrients Webpage - peace-is-happy.org/how are you feeling Transcript/Reference list How Are You Feeling? episode: Perseverance and Self Control - the dACC. The dACC part of the brain, the dorsal Anterior Cingulate Cortex, may be a center for processing input from other areas of the brain that have to do with current physical sensations, thoughts, and emotional feelings. Disclaimer: This information is provided for educational purposes within the guidelines of Fair Use. It is not intended to provide individual guidance. Please seek a health care provider for individualized health care guidance.
The feeling of curiosity may be similar to intrinsic motivation - an internal drive to explore, learn, practice and improve skills. We may have more intrinsic motivation or curiosity about something when we have two things: competence - the challenge is reasonably matched to our current skill level - it would be achievable with some effort, and autonomy - freedom to try without severe risks linked to any potential mistakes. Extrinsic motivation is an external force encouraging or coercing action - a school grade or job bonus is linked to the effort. Being allowed to be curious may help children and adults to achieve better success with grades, decisions, and even long term mental health. Image Quote: "A good traveler has no fixed plans and is not intent on arriving." - Lao Tzu Email - jen@peace-is-happy.org Twitter - @denutrients Webpage - peace-is-happy.org/how are you feeling Transcript/Reference list How Are You Feeling? episode: Perseverance and Self Control - the dACC. The dACC part of the brain, the dorsal Anterior Cingulate Cortex, may be a center for processing input from other areas of the brain that have to do with current physical sensations, thoughts, and emotional feelings. Disclaimer: This information is provided for educational purposes within the guidelines of Fair Use. It is not intended to provide individual guidance. Please seek a health care provider for individualized health care guidance.
Emotions may have to do with motivation, and learning self control and perseverance along with the value of rewards and changing strategy as needed or correcting errors to increase reward. The dACC part of the brain, the dorsal Anterior Cingulate Cortex, may be a center for processing input from other areas of the brain that have to do with current physical sensations, thoughts, and emotional feelings. Happiness and positive emotions may be motivating us to do more healthy behaviors that might help reduce stress and infection. Email - jen@peace-is-happy.org Twitter - @denutrients Webpage - peace-is-happy.org/how are you feeling Transcript/Reference list Disclaimer: This information is provided for educational purposes within the guidelines of Fair Use. It is not intended to provide individual guidance. Please seek a health care provider for individualized health care guidance.
We talk with DACC President Monica Torres about the upcoming DACC Golf Tournament and also the upcoming general election.
we all know what it feels like to be rejected by a friend, loved one or coworker. But did you know that rejection has actual physiological effects on your body and brain? Today Brett and I discuss the very real effects of social rejection. Social Rejection https://aeon.co/essays/health-warning-social-rejection-doesnt-only-hurt-it-kills social rejection = physical pain Naomi Eisenberg Anterior Insula (AI) Dorsal Anterior Cingulate Cortex (dACC) CyberBall Baumeister: the more severe the perception of rejection causes ego-shock = shut down of emotional response https://www.apa.org/monitor/2012/04/rejection Social rejection by groups you dislike and being paid to be rejected do not lessen the reaction African-Americans rejected by KKK members Exercise and other behaviors that cause the release of endorphins minimize the effect Crying releases endorphins as well https://www.sciencedaily.com/releases/2018/06/180614212911.htm mindfulness helps deal with social rejection mindful people have less activation of left Ventrolateral Prefrontal Cortex (lVCP) which is known to assist in top-down inhibitory regulation connections between lVCP and amygdala and dACC are less functional in mindful people bottom-up regulation is better than top-down https://www.youtube.com/watch?v=TLHlfPTRekA Bottom-up: Perception directs Cognition Information taken in through sense organs directs the construction of world view I see and hear a mosquito and then construct a plan to swat it Top-down: Perception is constructed by cognition Known information is used to construct a world view I can walk through my dark house because I know how the furniture is arranged In top-down out of the ordinary or unexpected factors lead to negative perceptions
Get the Ledger Nano X to Safely store your Crypto - https://www.ledgerwallet.com/r/acd6Help support the channel by joining my Patreon group - https://www.patreon.com/thinkingcryptoSign up with Coinbase for Free and get $10 free Bitcoin when you spend $100! - https://www.coinbase.com/join/59db057...Easily purchase Altcoins such as XRP, Cardano and more on the Binance exchange - https://www.binance.com/?ref=2157551Download Brave Browser to Earn Free Basic Attention Tokens - https://brave.com/thi921Follow on Twitter - https://twitter.com/ThinkingCrypto1Follow on Facebook - https://www.facebook.com/thinkingcrypto/Website - http://www.ThinkingCrypto.com/=================================================Help support the channel! Donations :BTC - 3GPcKwB3UGML4UiYqZM6BYx7Nu5Dj7GKDDETH - 0x7929e49cabe8d95d31392eaf974f378b508da2f4LTC - MWMhsyGX7tsTPGS2EtSCAWpy3ywCv25r6BXRP - rDsbeomae4FXwgQTJp9Rs64Qg9vDiTCdBv Destination Tag - 35594196=================================================#Bakkt #Bitcoin #Crypto- Bakkt Acquires Crypto Custodian Digital Asset Custody Company (DACC), Partners With BNY Mellon on Key Storage- American venture capital giant Andreessen Horowitz looks set to give mass adoption of cryptocurrency a further boost by investing an enormous $1 billion into the technology behind Bitcoin.- Banks Can’t Snub Crypto Startups Thanks to France’s New Blockchain Law- Finland Begins Regulating Crypto Service Providers- Jaguar Land Rover Plans to Give Drivers IOTA in Return for Their Data- SEC Temporarily Suspends Trading in Little-Known Bitcoin Miner’s Shares
Pascal Gauthier, President of Ledger, the provider of the popular crypto hardware wallet to update us on the future of the company. Topics include Komainu (Ledger partnered with Nomura to create a full-service institutional crypto service), Ledger Vault and the future of the company. - Ledger has sold 1M+ hardware wallets; whats next on the roadmap and functionality. - A discussion on Ledger Vault the institutional custodian offering; custody can unlock billions of inflows in our opinion. - How ledger Vault differentiation vs Gemini, Coinbase, DACC, Kingdom Trust and competitors. - Why ledger is the most secure institutional custody provider. - Ledger’s institutional custodianship offering is competitively priced, especially in comparison to gold. - Details on Komainu the first full custodian ready for institutional money. With Nomura. Komainu will hold the private keys. - Ledger can easily implement updates faster than exchanges to support new cryptocurrencies - Ledger’s future plans to support security tokens. Add your email on 51pct.io for our extensive research reports. 51percent's Institutional Crypto Podcasts are to the point discussions with crypto leaders for analysts, funds and institutions. Make sure to add your email on 51pct.io Disclosure: Tom Shaughnessy owns tokens in ETH. This podcast is NOT investment advice and is only informational. Do not make investment decisions based upon this podcast.
In July in San Francisco, I moderated a panel at "Distributed 2018: Unlocking the Global Power of Decentralized Business." The title of our discussion was "Innovate or Reinvent?" and the panelists were Amber Baldet, cofounder and CEO of Clovyr, Matt Roszak, cofounder and chairman of Bloq, and Lily Liu, cofounder of Earn.com. We had a wide-ranging discussion, which included topics such as how the "Crypto 50" combined have more budget for blockchain development services than Fortune 50 companies, how developing in the blockchain space and revolutionize an existing market requires that the new offering be many times better than existing options, and why enterprise needs to wait to get permission rather than ask for forgiveness, which doesn't hinder new projects. We also discussed how government is also a competitor in the space, that building entities don't include only decentralized projects and corporations, and how regulation could affect the development of the space. Thank you to our sponsors! DACC: https://www.digitalassetcustody.com Quantstamp: https://www.quantstamp.com The Sun Exchange: https://www.thesunexchange.com Episode links: Distributed conference: https://2018.distributed.com Amber Baldet: https://twitter.com/AmberBaldet Clovyr: https://clovyr.io Matt Roszak: https://twitter.com/MatthewRoszak Bloq: https://www.bloq.com Lily Liu: https://twitter.com/calilyliu Earn.com: https://earn.com
In July in San Francisco, I moderated a panel at "Distributed 2018: Unlocking the Global Power of Decentralized Business." The title of our discussion was "Innovate or Reinvent?" and the panelists were Amber Baldet, cofounder and CEO of Clovyr, Matt Roszak, cofounder and chairman of Bloq, and Lily Liu, cofounder of Earn.com. We had a wide-ranging discussion, which included topics such as how the "Crypto 50" combined have more budget for blockchain development services than Fortune 50 companies, how developing in the blockchain space and revolutionize an existing market requires that the new offering be many times better than existing options, and why enterprise needs to wait to get permission rather than ask for forgiveness, which doesn't hinder new projects. We also discussed how government is also a competitor in the space, that building entities don't include only decentralized projects and corporations, and how regulation could affect the development of the space. Thank you to our sponsors! DACC: https://www.digitalassetcustody.com Quantstamp: https://www.quantstamp.com The Sun Exchange: https://www.thesunexchange.com Episode links: Distributed conference: https://2018.distributed.com Amber Baldet: https://twitter.com/AmberBaldet Clovyr: https://clovyr.io Matt Roszak: https://twitter.com/MatthewRoszak Bloq: https://www.bloq.com Lily Liu: https://twitter.com/calilyliu Earn.com: https://earn.com
Roham Gharegozlou, CEO of Dapper Labs, the company behind CryptoKitties, and Benny Giang, Dapper Labs' head of Asia, describe how employees at venture studio AxiomZen came up with the idea for CryptoKitties, what problems it exposed in crypto (beyond scaling!), and how CryptoKitties can teach people the value of decentralization. They also defend the $140,000 price tag on one kitty, explain how they plan to grow from the current 300 users per day that the blockchain is logging, and surmise that if it weren't for user experience issues, CryptoKitties could have been 100 times bigger. Plus, they talk about the Kittyverse. Thank you to our sponsors! DACC: https://www.digitalassetcustody.com Quantstamp: https://quantstamp.com The Sun Exchange: https://thesunexchange.com Episode links: CryptoKitties: https://www.cryptokitties.co AxiomZen/Dapper Labs: https://www.axiomzen.co Roham Gharegozlou: https://www.linkedin.com/in/roham Benny Giang: https://www.linkedin.com/in/bennygiang/ The $140,000 CryptoKitty: https://www.nytimes.com/2018/05/18/style/cryptokitty-auction.html Fundraising news: https://techcrunch.com/2018/03/20/cryptokitties-raises-12m-from-andreessen-horowitz-and-union-square-ventures/ CryptoKitties on HTC's new phone: http://fortune.com/2018/07/11/cryptokitties-app-htc/ Listen to previous episodes of Unchained with these CryptoKitties investors: Chris Dixon: http://unchainedpodcast.co/chris-dixon-on-how-trust-is-the-best-lego-block-ep70 Naval Ravikant: http://unchainedpodcast.co/naval-ravikant-on-how-crypto-is-squeezing-vcs-hindering-regulators-and-bringing-users-choice Bill Tai: http://unchainedpodcast.co/maitai-globals-bill-tai-on-why-blockchain-is-the-6th-wave-of-technology William Mougayar: http://unchainedpodcast.co/icos-why-people-are-investing-in-this-380-million-phenomenon "Developers all the way down" -- Unchained episode with Meltem Demirors and Jill Carlson: http://unchainedpodcast.co/episode-74 Listen to my previous interview with Arianna Simpson on Unconfirmed about CryptoKitties: http://unconfirmed.libsyn.com/arianna-simpson-of-autonomous-partners-on-privacy-cryptokitties-and-crypto-regulation
Roham Gharegozlou, CEO of Dapper Labs, the company behind CryptoKitties, and Benny Giang, Dapper Labs’ head of Asia, describe how employees at venture studio AxiomZen came up with the idea for CryptoKitties, what problems it exposed in crypto (beyond scaling!), and how CryptoKitties can teach people the value of decentralization. They also defend the $140,000 price tag on one kitty, explain how they plan to grow from the current 300 users per day that the blockchain is logging, and surmise that if it weren't for user experience issues, CryptoKitties could have been 100 times bigger. Plus, they talk about the Kittyverse. Thank you to our sponsors! DACC: https://www.digitalassetcustody.com Quantstamp: https://quantstamp.com The Sun Exchange: https://thesunexchange.com Episode links: CryptoKitties: https://www.cryptokitties.co AxiomZen/Dapper Labs: https://www.axiomzen.co Roham Gharegozlou: https://www.linkedin.com/in/roham Benny Giang: https://www.linkedin.com/in/bennygiang/ The $140,000 CryptoKitty: https://www.nytimes.com/2018/05/18/style/cryptokitty-auction.html Fundraising news: https://techcrunch.com/2018/03/20/cryptokitties-raises-12m-from-andreessen-horowitz-and-union-square-ventures/ CryptoKitties on HTC's new phone: http://fortune.com/2018/07/11/cryptokitties-app-htc/ Listen to previous episodes of Unchained with these CryptoKitties investors: Chris Dixon: http://unchainedpodcast.co/chris-dixon-on-how-trust-is-the-best-lego-block-ep70 Naval Ravikant: http://unchainedpodcast.co/naval-ravikant-on-how-crypto-is-squeezing-vcs-hindering-regulators-and-bringing-users-choice Bill Tai: http://unchainedpodcast.co/maitai-globals-bill-tai-on-why-blockchain-is-the-6th-wave-of-technology William Mougayar: http://unchainedpodcast.co/icos-why-people-are-investing-in-this-380-million-phenomenon "Developers all the way down" -- Unchained episode with Meltem Demirors and Jill Carlson: http://unchainedpodcast.co/episode-74 Listen to my previous interview with Arianna Simpson on Unconfirmed about CryptoKitties: http://unconfirmed.libsyn.com/arianna-simpson-of-autonomous-partners-on-privacy-cryptokitties-and-crypto-regulation
In this hilarious skeptics' episode, Meltem Demirors, chief strategy officer of CoinShares, and Jill Carlson, an independent consultant, explain why they think crypto needs fewer moral arguments and more empirical evidence, and how there's too much focus on financial engineering, but not enough focus on winning hearts and minds. They also explain why people are not machines where "you put in a token and get out an action," what the "sh*tcoin waterfall" is, and why cryptoeconomics isn't anything new. Plus, they give their tips for working in the space. Thank you to our sponsors! DACC: https://www.digitalassetcustody.com Preciate: https://preciate.org/recognize/ Quantstamp: https://quantstamp.com Episode links: Meltem on Twitter: https://twitter.com/melt_dem On Medium: https://medium.com/@Melt_Dem Jill on Twitter: https://twitter.com/_jillruth AirTM: https://www.airtm.io Fat protocols thesis: http://www.usv.com/blog/fat-protocols Amber Baldet's tweet about the finger guns guy: https://twitter.com/amberbaldet/status/1006286345122275331 Meltem's tips on working in crypto: https://medium.com/@Melt_Dem/so-you-want-to-work-in-crypto-57961ca074c4 Jill's tips on working for yourself: https://medium.com/@jillcarlson/working-alone-165ababeafc2
In this hilarious skeptics' episode, Meltem Demirors, chief strategy officer of CoinShares, and Jill Carlson, an independent consultant, explain why they think crypto needs fewer moral arguments and more empirical evidence, and how there's too much focus on financial engineering, but not enough focus on winning hearts and minds. They also explain why people are not machines where "you put in a token and get out an action," what the "sh*tcoin waterfall" is, and why cryptoeconomics isn't anything new. Plus, they give their tips for working in the space. Thank you to our sponsors! DACC: https://www.digitalassetcustody.com Preciate: https://preciate.org/recognize/ Quantstamp: https://quantstamp.com Episode links: Meltem on Twitter: https://twitter.com/melt_dem On Medium: https://medium.com/@Melt_Dem Jill on Twitter: https://twitter.com/_jillruth AirTM: https://www.airtm.io Fat protocols thesis: http://www.usv.com/blog/fat-protocols Amber Baldet's tweet about the finger guns guy: https://twitter.com/amberbaldet/status/1006286345122275331 Meltem's tips on working in crypto: https://medium.com/@Melt_Dem/so-you-want-to-work-in-crypto-57961ca074c4 Jill's tips on working for yourself: https://medium.com/@jillcarlson/working-alone-165ababeafc2
Carole speaks with CJ Soliday, a Behavioral Health Specialist at the Delaware Area Career Center in Ohio. They discuss the vital role that CJ plays in helping the students of DACC succeed including her work with students with diagnosed mental health needs, helping to identify students with undiagnosed needs, and assisting in urgent mental health needs. For more We Love Schools, visit www.weloveschoolspodcast.com.
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