From the Spectrum: Finding Superpowers with Autism

In this episode we explore spindle neurons, also known as von Economo neurons (VENs), discovered by Constantine von Economo in the 1920s. These large, cylinder-shaped cells, found in the anterior cingulate cortex (ACC), anterior (or called frontoinsula) insula, and rarely the dorsolateral prefrontal cortex (DLPFC), are crucial for rapid communication in social behaviors. Three key points stand out: first, spindle neurons are located exclusively in the ACC and insula, the core hubs of the salience network, which is disrupted in autism as early as six weeks of age, as shown in a UCLA study. Second, these neurons are primarily involved in social behaviors, underpinning complex interactions in humans and other social species. Third, they are rare, found only in highly social animals like great apes, cetaceans, and possibly elephants, highlighting their evolutionary significance. In autism, increased spindle neuron density in the insula of children aged 4–14 is linked to early brain overgrowth, though this normalizes in adulthood due to pruning.The salience network, driven by the ACC and anterior insula, relies on spindle neurons to process relevant stimuli, integrate sensory data, and guide social-emotional responses. In autism, hyper-connectivity between the insula and sensory regions causes sensory hypersensitivity, while hypo-connectivity with prefrontal areas, including the DLPFC, impairs social cognition and adaptive behaviors. This disrupts the network's ability to switch between the default mode network and executive functions, often trapping autistic individuals in an internal world. Spindle neurons are also linked to disorders like frontotemporal dementia, schizophrenia, Alzheimer's, and emotional dysregulation.Daylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism0:00 Chroma Light Devices, use "autism" for 10% discount3:10 Spindle Neurons; Interesting Point #1: Salience Network6:03 Interesting Point #2: Rapid Communication & Social Behaviors7:11 "rediscovery" of Spindle Neurons in 1990s by John Allman8:30 Interesting Point #3: Highly Social Species10:57 Neuropeptide Y & Monoamine- Dopamine & Serotonin11:45 Morphology of Spindle Neurons & In Utero-Children; Social Learning12:54 Species with Spindle Neurons14:47 Small Clusters within the dlPFC15:08 Salience Network, ACC, Anterior Insula; Fulcrum for Default Mode and Executive Networks22:48 Daylight Computer Company, use "autism" for $25 discount27:08 Diseases/Conditions associated with Spindle Neurons29:26 The Autistic Phenotype (!!) -- The Whole Reason for the Podcast32:25 Reviews/Ratings, Contact InfoX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

In this episode, we discuss Autism with Dr. Catherine Lord. Dr. Lord is a Distinguished Professor of Psychiatry and Education at UCLA and one of the foremost researchers in Autism. Dr. Lord provides tremendous insights into her roles in Autism and Autism Assessment.Dr. Lord discusses her journey into Autism, the evolution of the Assessment including the ADOS growing from her basement and being overran by demand to the Gold Standard, the Challenges with understanding the Spectrum, updates on the Lancet Commission and Profound Autism, and Barriers in the Medical and Educational Systems.https://www.semel.ucla.edu/autism/team/catherine-lord-phdhttps://childmind.org/bio/catherine-lord-phd/https://labs.dgsom.ucla.edu/lord/pages/our_teamAutism and Education https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000656055638The mention of a recent article on Predicting Profound Autism and Cell Biology and me shying away from saying "Organoids" in real-time https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11127428/Daylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism(0:00) Intro(3:22) Dr. Lord's journey into Autism and Recognizing a Spectrum(11:25) The Evolution of Autism Assessment and Discussion on the ADI and ADOS- from making the ADOS in her Basement and being Overran by Demand to the Gold Standard; Revisions of Assessment Instruments(16:36) Gaps in the Autism Assessment(23:15) The Challenges with Understanding the Spectrum of Autism(29:32) Updates on the Lancet Commission and Profound Autism(35:19) Barriers with Autism and the Medical Field(39:29) Barriers with Autism and Education- Four Strikes against the Autistic Phenotype: Sensory-Processing, Speech and Language, Social Communication/Interaction, and Subject Switching (understand B3: Fixated Interests)(44:25) The Future of Autism and Helping Autistics Across the Life Span(51:03) Reviews/Ratings and Contact InfoX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

In this episode, we explore the impact of tech use and blue light on circadian biology, exploring how melanopsin and chromophores regulate physiology, mood, and cell functioning. The discussion highlights the leptin-melanocortin pathway, its role in placental physiology, and how ultra-weak biophotons from placental mitochondrial DNA influence fetal development, emphasizing the critical interplay of light and dark cycles in health.We further examine fetal brain development, focusing on mitochondria, neurogenesis, and the effects of UV light and nitric oxide on the thalamus and sensory integration. The episode connects BH4, tryptophan, and melanin deficits to Autism, discussing how environmental light and electromagnetic fields disrupt biological energy, contributing to neurodevelopmental problems and the Autistic phenotype.Daylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism00:00 Daylight Computer Company, use "autism" for $25 discount04:17 leptin-melanocortin pathway, biophotons, mitochondria, POMC, nitric oxide, BH4, fetal, placental physiology, fertility, ultra-weak biophotons, maternal blood, quantum biology, melanin, UV08:00 endocannabinoid, UV light, 380 nanometer, melanopsin, photo switch, brain development, leptin, mTOR, mitochondria, thalamus, sensory integration center, neurogenesis, fetal thalamus12:00 nitric oxide, autism, BH4, fetal ATP production, tryptophan, cellular redox, BPA, fluoride, deuterium absorption, electromagnetic fields, semiconduction, brain growth, biological energy16:03 Chroma Lights for Humans, use "autism" for 10% discount20:04 leptin-melanocortin pathway, leptin, adipose tissue, melanopsin, hypothalamus, POMC, placental physiology, ultra-weak biophotons, melanin, semiconductor, antioxidant, maternal physiology, brain volume24:23 biophotons, living cells, mitochondrial activity, cellular communication, electromagnetic waves, UV light wavelengths, energy, mitochondria, reactive oxygen species, TCA cycle, placental efficiency, thalamic timing28:29 mitochondrial DNA, retrograde signaling, gene expression, environmental cues, autism, heteroplasmy, biophoton coherence, calcium release, acetyl coenzyme A, fetal thalamus, neurogenesis, environmental light32:29 leptin-melanocortin pathway, neurodevelopmental problems, biophotons, somnathogenesis, circadian abnormalities, melanin, neural semiconduction, hyper excitability, hyper connectivity, salience network, attention, autistic phenotype36:34 Reviews/Ratings, Contact InfoX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

My guest today is a special Mother's Day edition with Katie Asher. Katie is a devoted mother of five and founder of Asher House, who shares her inspiring journey of raising her son Houston, who has severe autism. Katie discusses the challenges of navigating trauma, loss, and an abusive past, all while advocating for Houston's voice through groundbreaking communication methods like letter boards. She recounts the transformative moment when Houston, previously nonverbal, began spelling to communicate, revealing his profound intelligence and telepathic abilities, which reshaped her worldview and deepened their spiritual connection. Their story, detailed in their co-authored book The Book of Heaven, highlights resilience, faith, and the fight for recognition and inclusion for non-speaking individuals.Katie also critiques systemic failures in education and healthcare, exposing how institutions often dismiss the capabilities of those with autism, prioritizing profit over humanity. She passionately advocates for presuming competence, emphasizing the need for trust, love, and proper motor coaching to unlock communication. Through her experiences, Katie calls for a societal shift toward kindness, truth, and justice, urging listeners to value every soul and embrace the spiritual abundance that fosters unity and hope. Join us for an emotional and thought-provoking conversation that challenges assumptions and celebrates the power of connection.Katie Asher X https://x.com/KTAsher5Katie Asher Instagram https://www.instagram.com/asherhousehope/p/DHrUwDtv2R_/?img_index=1Asher House https://www.asher.houseThe Book of Heaven https://www.amazon.com/dp/1737898608DTP Hib https://en.wikipedia.org/wiki/DPT-Hib_vaccineImmune Thrombocytopenic Purpura (ITP) https://en.wikipedia.org/wiki/Immune_thrombocytopenic_purpura0:00 Katie Asher1:33 Katie's Intro into Autism7;24 Challenges with the medical paradigm; Profits over Humanity13:35 Understanding Intelligence & Communication; Telepathy & Sensory Processing25:18 Spelling 2 Communicate31:24 Houston Pops In37:26 Building Trust & Communication Skills46:19 The Instinctual Desire to be Known48:00 Understanding Non-Verbal Communication50:26 The Abundance Mindset51:30 Unity through Truth & Justice52:42 The Struggles of Parents of Autistic Children54:10 The Role of Technology in Communication56:36 The Challenges of Motor Control1:00:00 Eloping & Self-Injurious Behavior; Being drawn to Water1:02:05 The Connection to Water1:03:50 Energy & Spiritual Connection1:05:46 The Role of Humanity in Nature1:07:31 The War between Nature & Machine1:08:35 Telepathy & Communication1:11:43 The Impact of Thoughts on Life1:15:50 Trusting God in Doubt; Contact InformationX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

My guest today is John Coates. John is the founder of RFsafe, and he is on a mission from a personal commitment to understand and educate the harms of non-native Electromagnetic Fields. John takes us through a passionate and personal story and educates us on many topics around these modern products. We explore cell phones, microwaves, routers, WIFI, computers, towers, and more. John also educates us about regulation changes such as Section 704 that prevents questioning the health factors related to our modern man-made environment. In addition, John offers a solution to the harms of WIFI by telling us about LIFI, or light fidelity. By the end of this episode, we hope you understand more about health implications related to these non-native EMFs.RF safe https://www.rfsafe.comSection 704 https://www.rfsafe.com/section-704-and-fcc-guidelines-cemented-a-dangerous-wireless-monopoly-at-the-expense-of-health-and-innovation/FCC https://www.fcc.gov/engineering-technology/electromagnetic-compatibility-division/radio-frequency-safety/faq/rf-safetyDaylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism00:00 John Coates02:20 Personal Mission & Commitment08:14 A fight for change; Policy & Tech11:29 Hidden Dangers of nnEMF14:19 Unconstitutional Laws & Public Health; Protecting Big Tech17:12 The Need for Safer Tech; Section 70420:34 LiFI, Light Fidelity23:20 Environment Emergency in Schools39:37 Evolution of nnEMF & Human Health42:31 nnEMF & Autoimmune Diseases51:45 Bioelectric Dissonance & Development01:03:42 The Role of Natural Environment & Health01:12:48 The Illusion of Safety in Tech01:16:50 Demanding Safer Tech for Children01:21:18 Bioelectric & DNA connection theory01:32:22 The Future of Personalized Health Solutions01:41:00 Scams of SRA; Cancer ratesX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

For today's episode we learn about the cerebellum with Dr. Reza Shadmehr. Dr. Shadmehr is a trailblazing neuroscientist whose groundbreaking work has reshaped our understanding of how the brain controls movement. With a rich academic journey—from a bachelor's in electrical engineering to a PhD in robotics and computer science, followed by a postdoctoral fellowship at MIT—Dr. Shadmehr now leads the Shadmehr Lab at Johns Hopkins University. We dive into his pioneering theories, including motor memory consolidation, state space theory, and the neural encoding of action by the cerebellum's Purkinje cells. The conversation explores the physics of motor movement, prediction, error correction, and the often-overlooked power of the cerebellum—a brain region Dr. Shadmehr calls an “underrated yet powerful” player in our daily lives.Dr. Shadmehr shares his personal path into neuroscience, sparked by a childhood fascination with the brain. This curiosity led him to blend engineering principles with biology, culminating in a lifelong mission to decode how the brain builds internal models for movement. We unpack the cerebellum's critical role in fine-tuning actions—like stopping the tongue precisely or ensuring eye movements hit their mark, to cutting-edge research with marmosets. The episode also touches on the interplay between reward, effort, and cerebellar function, revealing surprising discoveries about how this brain region cancels noise to keep our movements smooth and purposeful. Shadmehr Lab: http://shadmehrlab.orgPublications: http://shadmehrlab.org/publicationsYT Videos (Very Good !): https://www.youtube.com/@shadmehrlab1352Daylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism00:00 Reza Shadmehr02:26 Daylight Computer Company, use "autism" for $25 discount06:45 Chroma Light Devices- Lights Designed for Humans, use "autism" for 10% discount9:54 Reza's journey into Biomedical Engineering & Neuroscience16:26 Understanding the Cerebellum; 3 primary functions22:07 Neuronal Communication & Purkinje Cells; Sensory and Interneurons25:41 Cerebellum, eyes, and Autistic phenotype; Mesencephalon & other connections28:13 Excitation/Inhibition (E/I) balance; Video examples & Movement deficiencies 29:29 Layers of the Cerebellum34:08 E/I & Brain function36:30 Learning & Memory in the Cerebellum39:54 Dysfunction & Brain Compensation41:57 Basal Ganglia and Cerebellum43:48 Internal Calculators & Prediction49:42 Reward & Movement & Accuracy52:52 Movement control; Eye movements55:56 Purkinje Cells & Tongue movements; deceleration 59:47 Understanding Language of the Cerebellum 1:01:58 Future of Cerebellar Technology X: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

In this episode, we explore the critical role of serotonin in shaping sensory maps within the brain, a process vital for interpreting sensory input and navigating the world. Serotonin, a neurotransmitter and neuromodulator synthesized from the aromatic amino acid tryptophan, influences brain development by fine-tuning sensory systems. It modulates neuronal growth, synaptic connections, and plasticity, which are essential for creating accurate sensory maps in regions like the somatosensory cortex, visual cortex, and auditory cortex. These maps serve as blueprints for processing touch, vision, and sound, with serotonin regulating the pruning of connections in the thalamus and cortex to ensure precise sensory wiring.The episode also explores the broader biological implications of serotonin, emphasizing its role in both prenatal and postnatal development. Maternally derived serotonin, supplied via the placenta from the peripheral and enteric nervous systems, significantly influences fetal brain development, affecting proliferation, differentiation, and neuronal migration in sensory regions. Postnatally, serotonin continues to support sensory integration and mood regulation, working alongside oxytocin to facilitate bonding and stress buffering. We explore environmental factors, such as stress and modern lighting, on serotonin synthesis and the hypothalamic-pituitary-adrenal (HPA) axis, which regulates cortisol release. Daylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism0:00 Chroma Light Devices, use "autism" for a 10% discount03:12, Sensory Map Introduction and Serotonin's Role, The episode introduces sensory maps, neural blueprints that help the brain interpret sensory inputs like touch, vision, and sound, 04:30, Serotonin's Developmental Impact, Serotonin fine-tunes sensory systems by modulating neuronal growth, synaptic connections, and plasticity, creating precise sensory maps in the somatosensory, visual, and auditory cortices,06:04, Serotonin and Sensory Processing (Visual), Serotonin, sensory processing in the visual cortex08:29, Critical Periods and Neuroplasticity, sensory neurons and connections, pruning10:00, Brain Regions and Serotonin's Mechanisms, Serotonin, axonal guidance, neurogenesis, and migration via microtubules, brain-derived neurotrophic factor (BDNF), glutamate and GABA12:55, Serotonin and Sensory Processing (Somatosensory),13:51, Serotonin and Sensory Processing (Auditory),14:52, Stress and the HPA Axis, Cortisol, circadian rhythms and cortisol spikes, modern environments,16:16 Daylight Computer Company, use "autism" for a $25 discount20:38, Maternal Serotonin and Prenatal Influence; Postnatal Serotonin and Oxytocin; Tryptophan Metabolism and Neurodevelopment, placenta, fetal brain development, proliferation, differentiation, and neuronal migration, serotonin, oxytocin & bonding and stress buffering, TPH1 and TPH2, kynurenine pathwayX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

In this episode, we discuss Autism and Education. We explore some current condition within education and some personal experiences. Specifically, the school day is in complete conflict with Autism- both Criteria A and B. This is the primary factor with the challenges of Autism in Education. The classroom requires a Social Dynamic, a Speech and Language Dynamic, and Sensory-Processing Dynamic, which is 3 strikes against Autism. In addition, the subject switching throughout the school day complicates our path of learning- Our learning style prefers spending extended times on a single subject. Autism gives us the ability to be comfortable within ourselves and this accelerates our learning, our Superpowers. School and the world mostly requires the social communication and interaction. Antipsychotics https://www.marketresearchfuture.com/reports/antipsychotic-drugs-market-2784#:~:text=The%20antipsychotic%20drugs%20market%20size,period%20(2023%20%2D%202030). Pediatrician and Psychologists on the Medical Paradigm https://podcasts.apple.com/us/podcast/radically-genuine-podcast-with-dr-roger-mcfillin/id1573253801?i=1000624733618 Autism and Education https://www.fhautism.com/shop/autism-and-education-the-way-i-see-it-what-parents-and-teachers-need-to-know/ Thinking in Pictures https://www.grandin.com/inc/visual.thinking.html Autism and Intelligence and an Explanation https://www.youtube.com/watch?v=pxNg0xcadsM&t=316s (0:00) Intro; Autism and Education; Are Educators educated on Autism?; Biases from others towards the environment (7:00) The Prescription Era; Medication first Paradigm (10:32) The School Day- Conflicts with Criteria A and B; Limits a Capacity to Think; Underlying thoughts and feelings of agitation and frustration when learning; (13:15) Autism gives us the ability to be comfortable within ourselves; Are we like the so-called normal people, or not? (13:39) The Classroom- Social Dynamic, Speech and Language Dynamic, Sensory-Processing Dynamic, 3 strikes against Autism; (14:39) Subject Switching and Criteria B conflict (17:14) If you have met one child with Autism, you have met one child with Autism (17:49) Elementary School, 2 reasons why Reading is HARD, Social dynamic experience; (23:07) 4th Grade personal experience- easy task from the outside, tremendous difficulty for Autistics; (27:00) Art was fine, other subjects were not fine; Details to General versus General to Details; (27:58) High School personal experiences; Pathway to Success ＞ General Education; (29:52) Did I graduate, or Not? (31:56) SAT (32:43) Assessment Superpowers and Superdeficits- Very Superior to Severe/Impaired; Schools simply cannot accommodate to all- within group (Autistic to Autistic) or between group (Autistic to Masses) (36:34) Education Arrangement; Taking Notes is challenging (39:16) Wrap Up, Reviews, Ratings, Feedback, Contact Information

This episode explores the critical role of tryptophan, an aromatic amino acid, in forming tubulin—the key protein building microtubules, which act as cellular "train tracks" for structure and movement. We delve into how microtubules drive mitosis, the process of cell division essential for growth and repair, and discuss tryptophan's unique biochemical significance, including its single codon (UGG) and contributions to DNA methylation.We connect these cellular mechanisms to Autism, examining how microtubule disruptions may affect neuron proliferation and migration during prenatal development, potentially leading to sensory processing issues and altered connectivity. The episode highlights the intricate dance of cells in neural tube formation and emphasizes the need for deeper research into these upstream processes to uncover Autism's developmental roots.YT video of tryptophan and microtubules https://youtu.be/AY6GmS_AePk?si=K_ZTy5RjLGkm1hGdInner Cell Life video https://youtu.be/RrS2uROUjK4?si=DCHs927yteOZ00dWSee Stuart Hameroff, Martin Picard, Michael Levin, Jack Kruseuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139use "autism" for 10% discount athttps://getchroma.co/?ref=autism00:00 Daylight Computer Company, use "autism" for $25 discount04:22 tryptophan, aromatic amino acid, microtubules, mitosis; human biology, autism04:44 tryptophan, UGG codon, methionine, SAM, MTHFR, folate, DNA methylation; upstream biology, RNA, DNA06:04 microtubules, train tracks, mitosis, cell division, spindle, DNA separation; skin repair06:55 tryptophan, tubulin, microtubules, mitosis, intracellular transport, cell shape; Autism research, upstream processes9:25 Chroma Light Devices- Lights Designed for Humans, use "autism" for 10% discount12:27 tryptophan fluorescence, mitosis, prophase, prometaphase, metaphase, anaphase, telophase, cytokinesis; microtubules, chromosome movement, cell division, tissue repair15:58 mitosis, neural tube, embryonic development, neuron proliferation, migration; Autism, brain size, connectivity20:33 sensory processing, hyperconnectivity, synaptic pruning, microtubules; Autism, sensory sensitivities, cortical connections25:06 excitation-inhibition imbalance, microtubules, environmental toxins, light exposure, fertilization, blastocyst; Autism, prenatal development, cell polarity31:09 microtubules, neural tube, gastrulation, neurogenesis, synaptogenesis, ectoderm, mesoderm, endoderm; Autism, cell migration,37:18 outro, reviewsX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

In this episode, we explore Oxytocin and Vasopressin's vast roles in Human Biology. We time travel to cover the evolution of the two molecules and learn about their functions with developing and socializing. Oxytocin and Vasopressin are dynamic molecules whereby they are Peptides and Hormones. In addition, we cover previously discussed brain regions and how the molecules work alongside key Neuromodulators like Serotonin and Dopamine.Social Reward https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214365/Social Reward Requires Oxytocin and Serotonin in Nucleus Accumbens (Parvo Path) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091761/Magnocellular and Parvocellular social Information Processing https://www.cell.com/neuron/fulltext/S0896-6273(20)30770-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627320307704%3Fshowall%3DtrueMagnocellular and Parvocellular https://onlinelibrary.wiley.com/doi/10.1111/jne.12284Meta-Analysis of Intranasal https://pubmed.ncbi.nlm.nih.gov/?term=intranasal+oxytocin+autism&sort=pubdate&filter=pubt.meta-analysishttps://pubmed.ncbi.nlm.nih.gov/33400920/Intranasal Review https://pubmed.ncbi.nlm.nih.gov/38579916/(0:00) Intro; Oxytocin and Vasopressin; Episode Objectives(2:46) Oxytocin and Vasopressin; 700 million year time travel (Phylogeny)(4:12) Peptides and Hormones; Modes of Transmission- Endocrine, Paracrine, Synaptic(6:35) Proteins and Peptides; Amino Acids and Aromatic Amino Acids and Light(8:58) Magnocellular and Parvocellular(12:33) Roles of Oxytocin and Vasopressin and connections to various Brain Regions(22:20) Scientific Literatures(27:12) Oxytocin and Serotonin; 1) Reward Processing, 2) Fear Response, 3) Social-Emotional Processing(30:07) Oxytocin and Dopamine(31:08) Dopamine Receptors(31:37) GABA(33:57) Intranasal Oxytocin(36:08) Take aways from Intranasal Literature(37:24) Biggest Take Away (Magnocellular versus Parvocellular and Intranasal Administration)email: info.fromthespectrum@gmail.com

In this episode, we navigate the fascinating world of circadian rhythms and their profound impact on our health. We cover essential biology and protocols for human health, Autism or not. We will discuss how these natural cycles of light and dark regulate our biology, from hormone production to mood and cellular function, and why disruptions—particularly from artificial light—are a growing concern in modern society. Highlighting the role of melanopsin, a blue light-absorbing protein discovered as recently as 1998, we explore how exposure to LED and tech light can throw off our internal clocks, a challenge especially relevant for those with autism who often struggle with circadian rhythm issues.Modern life has two problems: 1) removing ourselves from the full sun spectrum and 2) extending the day with artificial light at night. This, in large part, explains the origins of Autism: 1) a lack of biological energy (energy from the full sun spectrum during development- remember the episodes on neurulation, embryo and womb) and 2) improper clock-timing in our biology (in large part, this is why the gastrointestinal comorbid problem is heavily involved with Autism).We also introduce actionable protocols to reset and maintain a healthy circadian rhythm, whether you're autistic or not, emphasizing the critical role of sunlight at different times of day—morning, midday, and evening. We will discuss innovative solutions like the Daylight Computer, a blue light-free, flicker-free device designed with sensory-sensitive users in mind, and Chroma light devices that harness specific wavelengths to enhance well-being. Alongside these insights, we touch on historical and environmental factors, including a thought-provoking comparison to the Amish lifestyle, to underscore how our modern world might be influencing Autism rates and overall health.use "autism" for $25 off athttps://daylightcomputer.com?sca_ref=8231379.3e0N25Wg3wuse "autism" for 10% discount athttps://getchroma.co/?ref=autism00:00 Circadian rhythms introduced; blue light's impact via melanopsin and Daylight Computer's benefits.00:42 Daylight Computer Company5:00 Blue light's harm, autism energy deficits, and artificial vs. natural light comparison.08:01 Melanopsin's role, modern light's disruption, and historical autism link to artificial light.12:01 Amish lifestyle comparison and modern environments' effect on autism rates.16:01 Morning sunlight protocol for circadian reset via SCN and melatonin timing.20:01 Morning sun primacy; Non-Negotiable 21:23 Chroma light devices for health24:33 Midday sun / UV light for longevity, evening sun's role, and ranking sunlight importance.28:01 Nighttime light management: avoid overhead lights, prefer candles/red lights, ensure dark sleep.32:01 Maternal health benefits, reviews/ratings, and social media/podcast engagementX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

For this episode, we discuss the roles and sensitivity of mitochondria with Dr. Richard Frye, MD, PhD. Dr. Frye received an MD and a PhD in Physiology and Biophysics from Georgetown University. He is board certified in Pediatrics, Neurology with special competence in Child Neurology, and as a Certified Principal Investigator. In addition, he has a Masters in Biomedical Sciences and Biostatistics from Drexel University. Dr. Frye has over 300 publications in leading journals and book chapters.Dr. Frye shares many figures during the conversation so the listener can follow along.Dr. Richard Frye https://drfryemdphd.comRossingnol Medical Center Facebook https://www.facebook.com/RossignolMedicalCenterNeurological Health Foundation https://neurologicalhealth.orgHealthy Child Guide https://neurologicalhealth.org/the-guide-5/Daylight Computer Company https://daylightcomputer.com?sca_ref=8231379.3e0N25Wg3wuse "autism" in the discount code for $25 coupon.This is the future of tech.Chroma Light Therapy https://getchroma.co/?ref=autismuse "autism" for a 10% discount,0:00 Dr. Richard Frye0:58 Daylight Computer Company5:17 Chroma Light Devices8:27 History of Leucovorin; low risk, high reward; Folate Receptor Alpha (FRa)10:25 Blood Brain Barrier; Folate; CSF (cerebral spinal fluid)14:04 DNA, RNA; MTHFR (Methylenetetrahydrofolate reductase)17:34 Cerebral Folate deficiency; BH4, Placenta & Womb23:35 Folate deficiency & Autism26:21 Clinical Studies & Data29:28 Folate & Mitochondria; Cerebral Folate Antibodies; White Matter Findings (!)34:45 Cerebral Folate deficiency & Ranges; Autistic Phenotypes: Language, Communication, & Behaviors40:45 Language & Communication; Self-Injurious Behaviors; Hyperactivity, Agitation; Treatment duration42:53 Folate Autoantibodies & Maternal Health & Markers45:30 Studies & Behavioral outcomes; inflammation & thyroid findings46:58 Neural development; Language connections, white matter tracts & distal connections48:53 Leucovorin for different severity/levels of Autism; Spinal Bifida51:08 Preparing for pregnancy53:50 Transgenerational aspects of Folate Autoantibodies Research; Prenatal Care & Awareness59:32 Guidance & SupportX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

Nicole Rincon https://www.nicolerincon.comNicole's X https://x.com/NicoleRinconPARossignol Clinic https://rossignolmedicalcenter.comTACA Info: https://tacanow.org/wp-content/uploads/2019/10/F-H-2-Nicole-Rincon-Beginning-Biomed.pdfTACA Talks: https://www.nicolerincon.com/videosPublications https://rossignolmedicalcenter.com/articles-publications/#published-2024-2-articlesNicole Episode 1 https://www.youtube.com/watch?v=BBkdgwVfcZINicole Episode 2 https://www.youtube.com/watch?v=auLReV0DHkQDaylight Computer Company https://daylightcomputer.comuse "autism" in the discount code for $25 coupon.This is the future of tech.Chroma Light Therapy https://getchroma.couse "autism" for a 10% discount,***THIS IS NOT MEDICAL ADVICE***0:00 Nicole Rincon1:10 Daylight Computer Company; DC-15:33 Pre-pregnancy checks; Vitamin D8:37 MTHFR, Folate; Mitochondria; CPR, ESR, Inflammation11:12 GI; CSA; Bacteria, Fungus, Parasites, Calprotectin; Zonalin; MS & Proteus Mirabilis13:06 Organic Acid Test (OAT); Clostridia15:24 MTHFR; C677, 1298; Folinic Acid19:02 Folate's role in pregnancy and development; Critical info about types and duration22:35 Cholesterol; Maternal & Child; Speech & Communication25:06 Telepathy; Autism Rates26:40 Dysbiosis; PCOS29:30 Cholesterol ranges & symptoms; mood, irritability, cognition, aggression; Cortisol & Hormones37:02 Dysbiosis symptoms; Self-Injurious, Posturing41:08 Identifying symptoms in Non-Verbal; Self-Injurious45:08 Importance of Gut Health & Checks; Vitamin D, Electrical Efficiency & Biological Energy48:17 Autistics and pale skin; too many are pale; supplementing Vitamin D, K2; Brands51:00 Proprietary blends warning; abbreviated doses; Fungal overgrowth, Yeast55:49 "Binders;" Magnesium61:00 Fungal Overgrowth & Autism; OAT, Clostridia, C. diff, aggression, self-injurious; Antibiotics & Probiotics1:05:42 Telepathy Tapes, Autism, Water (Cytochrome C Oxidase), Coherence; Luc Montagier NOT Emilio Del Giudice; Distal Connections via Water and NOT axons; OutroX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

Why doesn't the MESENCEPHALON further subdivide into larger regions of the brain?In this episode, we will expand on the neurulation time and focus on the brain formation, spotlighting the proencephalon, mesencephalon, and rhombencephalon, which emerge around days 22–23 of embryonic life. The proencephalon (forebrain) splits into the telencephalon—think cerebral hemispheres for cognition—and the diencephalon, home to the thalamus and hypothalamus for sensory and hormonal control. Meanwhile, the rhombencephalon (hindbrain) divides into the metencephalon (pons and cerebellum, key for movement) and myelencephalon (medulla, handling [mostly] autonomic essentials like breathing). The mesencephalon stands out as a non-subdividing relay hub. The mesencephalon offers tremendous insights into the Autistic phenotype with its roles in biasing the living organism's attention to the environment.Autism and the Womb https://youtu.be/NOVp4mIrougAutism, Neurulation, & Embryogenesis https://youtu.be/TXkc93uGNuwAutism & Eye Movements https://youtu.be/1amB5e9qzg4Autism & Sensory Processing Part 1 https://youtu.be/HPvwvtu5hB4Autism & Sensory Processing Part 2 https://youtu.be/iWy9RligzicDaylight Computer Company https://daylightcomputer.comuse "autism" in the discount code for $25 coupon.This is the future of tech.Chroma Light Therapy https://getchroma.couse "autism" for a 10% discount,0:00 Daylight Computer Company04:22 Neuralation and Brain Development05:09 Maternal Factors and Biomarkers (Tyrosine, Hypothyroidism, etc.)06:46 Tryptophan and Its Role in Embryogenesis08:34 Environmental Insults and Toxins09:19 Embryogenesis and Brain Formation (Proencephalon, Mesencephalon, Rhombencephalon10:43 Telencephalon10:57 Diencephalon12:34 Rhombencephalon12:52 Metencephalon13:35 Myelencephalon15:12 Evolutionary Perspective of the Mesencephalon21:39 Chroma Light Devices24:48 Mesencephalon's Role in Motor Control, Sensory Processing, and Autism; 27:12 Extrapyramidal motor system; Substantia Nigra, Red Nucleus30:11 Additional Nuclei of the Midbrain; Ocular Motor Nuclei; Edingher-Westphal; Trochlear nerve 31:58 Paraaqueductal Gray (PAG), "Retard Strength" and Its Role in Pain, Behaviors and Autism; "Freezing" in Flight, Fight, & Freeze 36:00 Eye Movements; learning & Neuroplasticity; Motor Planning, Proprioception, Language and Speech 38:20 Wrap UpX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

For today's episode, we go into the science of embryogenesis, focusing on neurulation—the critical process where the neural tube forms, laying the groundwork for the central, peripheral, and enteric nervous systems. We discuss how disruptions in this early developmental stage, influenced by factors like folic acid metabolism, the sonic hedgehog pathway, and genes such as PTEN (P10), could shape the autistic phenotype. From cell proliferation to migration, we connect these biological processes to autism, exploring how environmental factors—like a pregnant mother's exposure to artificial light versus sunlight—might alter developmental outcomes. This episode sets the stage for when the Autistic phenotype begins and for more detail on why the mesencephalon does not evolve into other cell types like the other three areas (prosencephalon, rhombencephalon, and spinal cord).Daylight Computer Company https://daylightcomputer.comuse "autism" in the discount code for $25 coupon.This is the future of tech.0:00 Daylight Computer Company4:20 Neurulation; primary & secondary6:26 Neural tube, MTHFR & Folate (Vitamin B9), DNA methylation11:51 Neuroepithelial Cells; Neural Crest, Surface Ectoderm, Mesodermal16:05 Environmental implications, proliferation, differentiation, and migration18:45 PTEN26:29 Modern Environments28:00 What do you think light is? Autism is in the Womb31:40 Hyper and Hypo-connectivity34:40 some rants35:51 Leo Kanner kid, Donald Tripplet; The Biology that gives us Autism allows us to be comfortable within ourselves; more rants, probably37:59 Review/Ratings & Contact InfoX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

For today's episode, we expand on Autism and Sensory Processing. We return to the mesencephalon—a brainstem region with superior and inferior colliculi—as a critical hub for sensory integration and attention bias. We cover four scientific articles, starting with Marco et al. (2011), which uses EEGs, MEGs, and fMRIs to reveal autism's auditory processing inconsistencies (e.g., delayed N100/M100 cortical responses), tactile hypersensitivity from overactive receptors, and visual processing quirks like reduced fusiform gyrus activation for faces. Russo et al. then explore brainstem-level deficits, showing autistic children's auditory brainstem responses (ABR) to speech syllables like "DA" exhibit poor neural synchrony and phase locking, especially in noise, due to disrupted wave V, A, D, F timing—linking these to language impairments. These findings point to biological roots, including denser neocortical mini-columns (30-40 vs. 50-60 microns in controls) and cerebellar Purkinje cell loss, impairing local processing and long-range connectivity.The episode continues with Leekam et al. (2007), confirming over 90% of autistic individuals have multi-modal sensory abnormalities—hypo- and hypersensitivity tied to serotonin and GABA dysregulation—persisting across life, while Tomchek and Dunn (2007) note 95% prevalence via caregiver reports, hinting at neural pathway disruptions. At some point, we need to acknowledge the mesencephalon's embryological stasis as one of four neural cell types, suggesting its evolutionary role in sensory modulation is key to Autism's biology. These articles collectively highlight altered neural circuitry, from brainstem to cortex, and biases us to remaining within ourselves. Remember, the biology that gives us Autism allows us to be comfortable within ourselves. Marco et al 2011 https://www.nature.com/articles/pr9201193Russo et al 2009 https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1467-7687.2008.00790.xLeekam et al 2007 https://link.springer.com/article/10.1007/s10803-006-0218-7Tomchek & Dunn 2007 https://affectautism.com/wp-content/uploads/2016/05/tomcheck_dunn.pdf0:00 Autism and Sensory Processing; comorbid conditions; Mesencephalon3:03 Article 1 Marco et al 20114:11 Auditory5:00 N100 & M100 tools9:17 Tactile11:23 Visual13:53 Multisensory Integration15:16 Postmortem; Cerebellum & Purkinje Cells; Minicolumns17:06 Speech19:02 Article 2 Russo et al; Brainstem scientists20:28 Auditory Brainstem Response (ABR); Quiet versus Noisy environments; Beatles comparison23:49 Neural Synchrony; Waves V, A, D, F24:33 Phase Locking27:34 Article 3 Leekam et al 2007; Neuroplasticity33:09 Article 4 Tomchek & Dunn 200736:36 Reviews/Ratings and Contact InfoX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

For today's episode, we discuss Autism and sensory processing. The episode expands on the concept of the mesencephalon (midbrain), touching on the superior and inferior colliculi, key regions that help extract and integrate sensory information. The role of melanin in sensory processing is highlighted, as it aids in signal transfer and increases efficiency in sensory organs, including the eyes, ears, and skin. The episode also connects these concepts to autism, noting that individuals with Autism often experience both hypersensitivity and hyposensitivity to sensory stimuli, affecting their interaction with the environment.The episode also dives into the biological foundations of sensory perception, focusing on the role of melanopsin and other chromophores in light absorption and how they influence wakefulness and sleep cycles. Additionally, we cover the auditory system, specifically how melanin in the cochlea contributes to hearing and how auditory processing can become overwhelmed in individuals with Autism, leading to sensory overload. The discussion then extends to the role of melanin in other systems, such as the gastrointestinal tract, and its connection to energy production and sensory perception. By exploring the pathophysiology of Autism at an early developmental stage, the episode emphasizes the need to investigate sensory processing and its integration across the nervous system to better understand Autism.Role of semiconductivity and ion transport in the electrical conduction of melanin https://pmc.ncbi.nlm.nih.gov/articles/PMC3384144/Dr. Jack Kruse: QUANTUM ENGINEERING #53: WHY IS MELANIN ALWAYS FOUND BETWEEN YOUR SENSES & THE ENVIRONMENT? https://www.patreon.com/posts/quantum-53-why-83720421Dr. Jack Kruse: QUANTUM ENGINEERING #45: AUTISM & MELANIN/MELANOPSIN: A MIGRATION PROBLEM https://www.patreon.com/c/DrJackKruse/posts00:00 Autism and Sensory Processing02:31 Mesencephalon's Role; Melanopsin; Chromophores05:02 Melanin in Sensory Systems07:33 Light and Quantum Biology10:04 Environmental Impact on Health; Hypo and Hypersensitivity12:35 Energy and Mitochondria15:06 Embryogenesis and Autism Origins; Neuralation, Neuroepithelial Cells17:37 Autism Research19:05 Reviews/Ratings & Contact InfoX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

In this episode, we discuss the connections between autism and eye movements, starting with the underappreciated role of eyes in human biology. We emphasize the significance of the retina, which is central to both image-forming and non-image-forming functions of vision. The discussion takes a turn towards how blind individuals also leverage their eyes for biological functions beyond sight, highlighting the pervasive influence of visual systems on human physiology. We explore the superior colliculus, an essential brain region that integrates sensory information from various sources, including vision, to direct our attention and reflexive responses. This area is crucial in understanding how sensory input differently, particularly in terms of attention bias and threat detection, which could explain some of the unique sensory experiences in Autism.We then touch upon the dorsal anterior cingulate cortex (dACC) and the roles in error detection, conflict monitoring, and effort evaluation. The dACC's involvement in these cognitive processes can provide insights into why certain social cues or environmental stimuli might be overwhelming or less salient for individuals on the spectrum. Additionally, the episode covers oxytocin, a hormone/neuropeptide involved in social bonding and emotional regulation, discussing its synthesis through magnocellular and parvocellular pathways in vision. What do you think oxytocin is doing here, for the cub and for you? https://www.reddit.com/r/NatureIsFuckingLit/comments/11q03yn/a_cub_puma_admiring_his_mother/?rdt=64743Eye-Tracking as an Early Biomarker of Autism https://youtu.be/fJpIRHOZZO4The Roles of Oxytocin and Vasopressin in the Autistic phenotype https://youtu.be/DAtmC-s1_e0Mesencephalon https://en.wikipedia.org/wiki/Midbrain#:~:text=The%20midbrain%20or%20mesencephalon%20is,view%20of%20one%20cerebellar%20hemisphere.00:00 - Introduction to Autism and Eye Movements; importance of eyes in biology, specifically mentioning the retina as a key player.04:19 - Non-Image Functions and Master Clock; Melanopsin; SCN- master clock08:13 - Eye Tracking and Autism Diagnosis; effectiveness at 14 months of age12:23 - Biological Underpinnings of Eye Movements in Autism; dorsal anterior cingulate cortex (dACC), Superior Colliculus & Mesencephalon & sensory integration, attention in the context of Autism & brain development16:48 - Sensory Integration & Superior Colliculus and Reflexive Responses & Biasing Attention.20:58 - Developmental Aspects of Autism; embryonic stage before the central nervous system25:11 - Vision and Autonomic Nervous Systemvision and breathing can influence stress and calmness & bidirectional connections27:47 Reviews/Ratings and Contact InformationX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

In this episode, we discuss the intricate relationship between Autism and speech & language, emphasizing the critical role of neuroscience in understanding these dynamics. The discussion begins by highlighting how speech and language are foundational to human evolution and social interaction, yet pose unique challenges for individuals with Autism. The episode explores the brain's key regions involved in these processes, such as Broca's area, responsible for speech production, and Wernicke's area, crucial for language comprehension. These regions are connected by the arcuate fasciculus, a white matter tract essential for language processing, repetition, and verbal working memory.The podcast also examines how the basal ganglia, particularly the dorsal striatum, contributes to speech fluency and motor sequencing, including the articulation of words. By integrating neuroscience, we gain insight into the biological underpinnings of communication difficulties in Autism, such as delays in language processing and the phenomenon of "choppy" speech, which are linked to less coherent organization within these neural pathways.The episode further unpacks the concept of neuroplasticity and its implications for Autism, emphasizing the brain's ability to adapt through practice and repetition, leading to habits. The discussion also touches on the role of the dorsal medial striatum in goal-directed learning and the dorsal lateral striatum in habit formation, illustrating how these areas influence speech and language acquisition. Additionally, the podcast explores the phenomenon of echolalia, often observed in Autistic individuals, as a potential mechanism for processing delays or as a result of cyclical loops in the basal ganglia.The interplay of neurotransmitters like GABA and glutamate is highlighted, explaining the excitation-inhibition imbalance often seen in Autism, which affects sensory processing and communication. By framing these challenges through the lens of neuroscience, the episode underscores the complexity of social interaction for Autistic individuals and the importance of understanding the brain's predictive and adaptive mechanisms to better support their needs.00:00 - Introduction to Autism and Speech02:02 - The Speaker-Receiver Dynamic in Autism04:02 - Visual Thinking and Processing in Autism06:18 - Neuroscience of Speech and Language08:20 - The Role of the Basal Ganglia in Speech10:39 - Echolalia and Sensory Processing Delays16:53 - Neuroplasticity and Speech Therapy17:22 - Reflexes, Inhibition, and GABA in Speech and Autism20:02 - Basal Ganglia Circuits, Motivation, and Echolalia from getting "stuck"24:03 - Language Acquisition and Rule-Setting in Autism27:47 - Energy, Learning, and Social Challenges30:15 - Contingency-Based Learning and Outcomes31:46 - Reviews/Ratings and Contact infoX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

In this episode, we explore the intricate world of autism research with Jill Escher, a dedicated philanthropist, lawyer, and parent to two Autistic young adults. Jill's journey into Autism advocacy was sparked by her children's diagnoses, with no prior family history, leading her to significant roles like president of the National Council on Severe Autism and leadership at the Autism Society in the San Francisco Bay Area. Through the Escher Fund for Autism, she examines the causes beyond genetics, investigating how environmental and biological factors might alter gene expression, contributing to Autism's heritability.Jill challenges the conventional genetic focus in Autism research, arguing that it fails to explain the increasing prevalence of Autism. She delves into complex topics like epigenetics and transcriptional regulation, proposing these might unlock the heritability puzzle of Autism. Her research includes looking at how factors like general anesthesia can affect future generations. Escher also discusses the hurdles in Autism research, including scientific dogma and the influence of the neurodiversity movement, urging for a more comprehensive approach to address what she sees as a looming national health crisis.Jill Escher https://www.jillescher.comHarvard Presentation: https://harvard.zoom.us/rec/play/n1wZBC2hwCOid8oKlQJLJECY7cGS0YeQMNlaSaFqu2Iybo8ADCEzrdqP01Q3lXTBRX73GHgWdYZMg5RT.Vwh6LCxdweMaleLf?canPlayFromShare=true&from=share_recording_detail&startTime=1733338808000&componentName=rec-play&originRequestUrl=https%3A%2F%2Fharvard.zoom.us%2Frec%2Fshare%2Fy3NWE-vbqRQB-lnpZ33Gk7HsbiTJPzi4xjXdCDudRMYtdNFYYC-URWaix3xiYe1e.22MUxTE70Dl-Yz62%3FstartTime%3D1733338808000Other ResourcesAutism and the Womb https://youtu.be/NOVp4mIrougThe Relationship of the Placenta, Womb, and Development https://youtu.be/Mj5h5DOMcRw0:00 Intro1:18 Jill's Journey into Autism4:25 Jill's Family & Autism7:19 Research & Advocacy in Autism10:19 Genetic & Heritability Explanation13:05 Non-Genetic Factors; Epigenetics21:08 Anesthesia; Germ Cell; Proliferation26:29 Early Brain Development; Gene Expression; RNA; Molecular level27:56 Research needs; Genetics & Dead End data; Society & Preparation of Prevalence33:57 Rates of Autism & Future (& Current) Emergency38:16 Vaccination41:25 Migration; Excitation/Inhibition Imbalance; Functional Connectivity48:02 Barriers in Autism; Jill's Contact Information53:33 Reviews/RatingsX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

In this episode, we delve into defining the Autistic Phenotypes, emphasizing that while these traits are straightforward to identify, understanding their depth and impact requires integrating real-life data and personal experiences. We explore the characteristics of repetitive behaviors, habits, restricted interests, and a rigid adherence to schedules, which are pivotal to the Autistic Phenotypes. We will also discuss the Basal Ganglia pathways, specifically how the direct and indirect pathways influence these behaviors, touching upon how these neural connections relate to both the strengths (Superpowers) and challenges (Superdeficits) faced by individuals on the spectrum.Our discussion extends into the biological and social aspects of autism, examining how the inherent biology of autism can lead to comfort within oneself, yet creates struggles when forced into societal norms. We'll address the notion of conflict within the nervous system, explaining how it responds reflexively to disruptions in established patterns or expectations. The episode will also cover the neurological underpinnings of autism, including the roles of dopamine, GABA, and the substantia nigra in modulating behaviors and habits. We'll connect these insights to the adaptive responses or the lack thereof, which are central to understanding why individuals with Autism might resist changes in routines or show intense focus on specific interests. Practical implications and the historical context from early Autism studies by Leo Kanner and Hans Asperger are revisited, offering a comprehensive view on how these traits manifest in real-life scenarios and affect social interactions00:00 Understanding Autistic Phenotypes: Repetitive behaviors, restricted interests, and adherence to schedules. Basal Ganglia & strengths (superpowers) and challenges (superdeficits).05:23 Neurological Mechanisms: Basal Ganglia's pathways (direct and indirect) & Autistic behaviors. Repetitive actions, learning, and habit formation; dopamine, excitation and GABA; Stemming and the discomfort with unpredictability in social contexts.10:39 "Motivation", Movement, and Social Interaction: "Motivation" and motor movements & the basal ganglia & Autism; Social interactions & unpredictable, significant challenges & predictability. The segment also links these neurological pathways to DSM criteria for autism, highlighting the interrelation between motor and social behaviors.15:55 Neuroplasticity and Adaptation: Neuroplasticity & the repeated strengthening of neural connections shape Autistic traits; adaptive responses managed by the prefrontal cortex, and resisting changes or adhere to routines. 20:52 Biological Energy: brain's energy management for learning and habit formation works in Autism; acetylcholine for focus, dopamine for persistenceX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuATikTok: (I don't love it) https://www.tiktok.com/@fromthespectrumpodcastemail: info.fromthespectrum@gmail.com

In this episode, we explore the connections between Autism and Parkinson's, focusing particularly on the basal ganglia and its substructures, notably the substantia nigra within the midbrain. We discuss how the substantia nigra, known for its high concentration of neuromelanin, plays a critical role in these disorders. The episode examines how neuromelanin, a dark pigment, not only absorbs all frequencies of light but also has antioxidant properties, binds metals, and acts as a neuroprotector. This discussion leads into the broader implications of environmental signals, particularly light, on human biology, touching on how modern changes in light exposure might affect these conditions.We examine the role of tyrosine in the synthesis of neuromelanin and its derivatives like dopamine, which are crucial for neural function. We look at how deficiencies or imbalances in these pathways could lead to the symptoms observed in Autism and Parkinson's, including motor function issues. The conversation also covers the direct and indirect pathways in the basal ganglia, explaining how these pathways facilitate or inhibit movement, respectively, and how their dysfunction can manifest in the characteristic motor symptoms of both disorders. We also touch on the significance of thyroid function, particularly the roles of T3 and T4 hormones, in brain development and neuron health, tying these elements back to the overarching theme of energy loss and transduction in both Autism and Parkinson's.Autism and Parkinson's are a lack of, or a loss of, energy.Biological Energy: Quantum Mechanisms, Water, DHA, and NF-kB: https://youtu.be/2-IA_gunXbwTree comparison https://youtube.com/shorts/cLu53oVRRjI0:00 Autism and Parkinson's; Basal Ganglia; Substantia Nigra; Neuromelanin; Internal Calculators2:15 Tyrosine; Chromophores; Aromatic Amino Acids3:50 Biological Energy; Mitochondria; Environmental Signals; Cytochrome C Oxidase; Autism Research Miss6:20 Deep Brain Stimulation6:48 Neuromelanin9:02 Reverse Engineer ATPase10:48 Tree Examples11:45 Hypoxia and loss of energy & dopamine12:26 Eyes, hair, & skin; RPE; efficiency & power; What is Light?13:58 Light; Information & Energy; electromagnetic; wave-particle duality; sunlight versus artificial light17:08 Thyroid; T3 & T4; Iodine18:31 Roles of T323:00 Loss of energy in the womb & Autism research25:00 Melanin + Water = Electrons26:40 Basal Ganglia; "Motivations" & Movements; Direct Pathway30:55 Indirect Pathway32:52 Go, No-Go; Action selection, learning & habits; fine motor skills34:18 Parkinson's and loss of timing & energy; modulating the two pathways & dopamine37:07 Reviews/Ratings & contact infoX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuATikTok: (I don't love it) https://www.tiktok.com/@fromthespectrumpodcastemail: info.fromthespectrum@gmail.com

Autism just magically shows up.In this episode, we explore neuroplasiticity in our biology for one common environmental change- Light. Please consider 1) Critical Thinking and 2) Curiosity as we travel upstream in the biological implications causing Autism. In addition, we will explore other common health conditions related to Light. These health conditions are dementia, type 1 diabetes, obesity, type 2 diabetes, cancer, and cardiovascular diseases.The episode will discuss light as an electromagnetic strip and how our biology uses this energy. We discuss the embryo, neuroectoderm (brain and skin), proteins being wide-band gap semiconductors, photoelectric effect, cytochromes and mitochondria, chromophores, and related topics."... I realized that all biochemistry is the bridesmaid to physics. I then realized that physics are how the business of cells gets completed. Light is the biophysical levers that control substrate level biochemistry in cells." - Dr. Jack Kruse(Start here) Regenerative Health with Dr. Max Gulhane and Dr. Jack Kruse https://www.youtube.com/watch?v=Ln3WszTq0uATetragrammaton with Rick Rubin, Jack Kruse, and Bill Gifford https://www.youtube.com/watch?v=EHe78j9UrMITetragrammaton with Rick Rubin, Jack Kruse, and Andrew Huberman https://www.youtube.com/watch?v=oK9_j6fa2P4Decentralized is the way (The Status Quo is NO GOOD) https://www.youtube.com/watch?v=VO4JwdXuXXsTryptophan Biosynthesis https://faseb.onlinelibrary.wiley.com/doi/epdf/10.1096/fj.04-2079revAutism and Vit Bs and Serotonin https://www.patreon.com/posts/quantum-19-74498277Autism and Melanin https://www.patreon.com/posts/quantum-45-83724567Regions of Interest:Atoms,Aromatic Amino Acids,Artificial Light,Chromophores,Cytochromes,Electromagnetic,Embryo,Folate Acid (and Folic Acid)Sunlight,Melanin (Neuromelanin),Melanocytes,Melanogenesis,Melanopsin,Mitochondria,Neuroectoderm,Neuroplasticity,Periodic Elements,Photoelectric Effect,Pro-opiomelanocortin (POMC)Proteins (wide-band gap semiconductors),Serotonin,Tryptophan Hydroxylase 1 and 2,Vitamins A, b9 (Folate/Folic Acids), B12, and D,WaterX: https://twitter.com/rps47586YTEmail: info.fromthespectrum@gmail.com

In this episode, we explore the Basal Ganglia. The basal ganglia are a group of subcortical nuclei that play a crucial role in orchestrating movement. They are involved in what's known as the 'Go, No-Go' decision-making process, where they help decide whether to initiate or suppress actions. This region is critical where motivation translates into action.When discussing "motivations," we must be cautious; motivations aren't consciously defined by us but by our nervous system, which operates based on learned behaviors, habits, and neural pathways. The nervous system is designed to conserve energy by automating responses, which explains why it favors habit formation over constant conscious decision-making. It responds based on what it has learned, including connections, habits, and the rules established by our internal calculators.General Description of the Basal Ganglia:Inputs: Caudate Nucleus and PutamenRelays: Globus Pallidus External (GPe) and Subthalamic NucleusOutputs: Globus Pallidus Internal (GPi) and Substantia Nigra Pars Reticulata (SNr)Modulator: Substantia Nigra Pars Compacta (SNc)00:00 - Defining the Autistic Phenotypes.00:17 - Exploration of basal ganglia, focusing on the dorsal striatum.00:40 - Explanation of connecting Autistic Phenotypes with behaviors and implications through biology.01:00 - Detailed description of the basal ganglia's role in subcortical functions.01:50 - Discussion on the relationship between eye and brain development.02:18 - Explanation of basal ganglia's role in motivation and movement convergence.03:02 - Insight into how the nervous system conserves energy and responds to known patterns.03:52 - Explanation of why change is hard due to basal ganglia functions.04:37 - paper on excitation-inhibition phenomena in autism.05:07 - Genetic implications in autism: SHANK3, Neuroexcin, Neuroligin,06:45 - Discussion on the enlargement of the dorsal striatum in autism.08:07 - Identification of the caudate nucleus and putamen as inputs to the basal ganglia.09:40 - Role of the putamen in motor skill acquisition and fine-tuning movements.11:59 - Connection between the putamen and Autism-related motor behaviors like stimming.13:30 - Discussion on Autistics preferring their inner world.16:04 - Importance of the substantia nigra and dopamine in human function.18:26 - Dopamine receptors and their roles in Autism.20:03 - Subdivisions of the substantia nigra and their functions.21:01 - Description of the globus pallidus and its role in basal ganglia circuits.22:29 - Feedback loops involving the globus pallidus and subthalamic nucleus.23:40 - Implications of delayed or inefficient signal loops in movement control.24:57 - Role of the thalamus in processing sensations.26:31 - Subthalamic nucleus as a major relay center for motor control.28:47 - Linking Autism criteria with basal ganglia function.30:20 - Coverage of all four criteria B symptoms related to Autism.32:14 - Morphology of neural connections in Autism.32:51 - Reviews and ratings.X: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuATikTok: (I don't love it) https://www.tiktok.com/@fromthespectrumpodcastemail: info.fromthespectrum@gmail.com

The biology that gives us Autism allows us to be comfortable within ourselves.Our biology orients the Autistic towards our internal state. This is more comfortable for the Autistic in comparison to the outside world. In this episode, we cover brain regions, networks, and internal calculators. All humans use these biological calculators. However, based on the living organisms unique structure of brain regions and networks (connections), it is easy to understand why people are different.Epinephrine & Glia https://www.sciencedirect.com/science/article/pii/S009286741930621XOther Resources: Autism and Adaptive Responses https://youtu.be/Zj3_e6ZjCGkAutism and Default Mode Network https://youtu.be/9CqyH4woB34Autism and Salience Network https://youtu.be/9ZbTztb3al8Autism and B.3 https://youtu.be/Ov_Bw--zzrQ00:00 - Introduction00:42 - Biology and Autistic Comfort03:05 - Salience Network Explanation05:06 - Attention Management in Autism08:35 - Default Mode Network in Autism09:47 - Introducing Internal Calculators & Neuromodulators; Neuroplasticity10:52 - Biological Responses in Autistic Behavior14:02 - Effort and Energy: The Role of Internal Calculators; Calculator for Effort vs. Outcome17:07 - Social Interaction and Energy Use20:23 - Dopamine and Internal Calculators; Reward Prediction Error as an Internal Calculator25:18 - Internal Calculators and Societal Norms; Impact of Social Expectations on Internal Calculators; NeuroplasticityX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuATikTok: (I don't love it) https://www.tiktok.com/@fromthespectrumpodcastemail: info.fromthespectrum@gmail.com

Understanding the roles of Thyroid with Autism & Parkinson's, and what is the missing link.Research misses the link. Do not rely on research to connect these conditions and point to the real cause. Both, Autism and Parkinson's, have two major factors, 1) clocked timing and 2) A loss of, or a lack of, energy.Two Questions are asked:1) What do you think Neuromelanin is?2) What do you think Light is?Maternal health and preconception testing for Autism https://youtube.com/shorts/C2yhaPoWdIYIodine: https://youtube.com/shorts/q3dv-bslEwQThyroid hormones and Autism https://youtube.com/shorts/SRnDzn4UvgcImpact of light on neurodevelopment and aging: Autism https://youtube.com/shorts/cLu53oVRRjIBasal Ganglia: our go no go area for learning & habits https://youtube.com/shorts/YWc8AxuGHHMBasal Ganglia: Motivation & Movements (you don't define Motivation, the nervous system does)https://youtube.com/shorts/5agnRtSC95UX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuATikTok: (I don't love it) https://www.tiktok.com/@fromthespectrumpodcastemail: info.fromthespectrum@gmail.com

later

A Year in Review from previous episodes. 00:00 - Intro 00:42 - Warning Against Comparing Rates; why comparing autism rates across different time periods is misleading due to changes in diagnostic criteria and definitions.02:07 - Historical Context; the Bayh-Dole Act, DSM acceptance of Autism, and changes in vaccination schedules, affecting Autism definitions; Core Autism Characteristics04:30 - Educational Challenges; Describes the typical school day's structure as potentially overwhelming for Autistic individuals due to frequent subject changes.05:36 - Intense Focus; Autistic individuals might fixate on topics with abnormal intensity or focus, which is a hallmark of Autism.08:40 - The biology of Autism allows us to be comfortable within ourselves; contrasting with societal expectations.09:09 - Employment and Anxiety; Considers how the expectation to fit into social norms can lead to anxiety and challenges in employment for Autistic individuals.10:10 - ADHD and Autism; Challenges the notion of coexisting ADHD and Autism, 14:26 - Early Detection; UCLA study on very young children showing altered salience network connectivity, hinting at early signs of Autism.14:49 - Developmental Timing; emphasizes that Autism likely starts in the womb, suggesting prenatal development as a critical area for research.15:14 - Neurodevelopmental Perspective; Autism as underdeveloped or abnormally developed cells, linking it to broader neurodevelopmental disorders.16:03 - Comorbid Conditions: Explores the concept of Autism being associated with various other conditions due to shared developmental issues.16:47 - Biological Processes: cellular proliferation, differentiation, and migration in the womb, crucial for brain development.17:41 - Mitochondria and Autism18:30 - Oxytocin & Autism; oxytocin as a molecule of interest, particularly its pathways and their implications for social behavior in Autism.20:29 - Social Reward System; Explains how oxytocin and serotonin interaction in the brain contributes to the rewarding nature of social interaction, which might be lacking in Autism.21:21 - Serotonin Synthesis; Details the synthesis of serotonin in both the GI tract and the brain, mentioning the enzymes involved and their significance.22:34 - Tryptophan and Light; Discusses how light affects tryptophan, an amino acid precursor to serotonin, and its role in biological processes.23:33 - Supplementing Relationships; Explores how visual thinking and movies can serve as a form of interaction for Autistic individuals, offering comfort or learning.25:17 - Visual Learning; Highlights the concept of "thinking in pictures" and how it leads to accelerated learning or Autistic intelligence.27:47 - Autistic Comfort and Societal Expectations; Advises against forcing Autistic individuals into societal norms that don't align with their natural inclinations, emphasizing understanding and acceptanceX; https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

In this episode, we discuss some difficulties with eye contact for the Autistic phenotype. Sensory processing and the rate of information comes fast, and this provides additional energy for an already challenging and exhaustive task. Humans are constantly extracting physical phenomena from the environment (sensations) and we process this information to inform our nervous systems (perceptions). Specifically in this episode, we discuss the differences between listening and speaking.X: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com

My guest today is Dr. Kristen Lyall, ScD. Dr. Lyall received a Doctor of Science in Epidemiology from Harvard School of Public Health. During her postdoctoral training, she received training in Nutrient Science at Harvard and Pediatric Epidemiology at UC-Davis MIND Institute's Autism Research Training Program. Currently, Dr. Lyall is an Associate Professor at Drexel University's A.J. Drexel Autism Institute – Modifiable Risk Factors Program.The overarching goal of the Modifiable Risk Factors program is to identify factors that can be changed to prevent or mitigate the adverse effects associated with Autism, thereby potentially improving outcomes for individuals and informing public health policy and practice. Dr. Lyall's expertise provides actionable tools for listeners to understand the environmental risks of Autism. By the end of the episode, we hope you gain insight into the identified modifiable risk factors for Autism.Dr. Kristen Lyall: https://drexel.edu/autisminstitute/about/our-team/all-staff/Kristen-Lyall/Dr. Lyall publications link: https://pubmed.ncbi.nlm.nih.gov/?term=Kristen%20Lyall&sort=pubdateECHO: https://echochildren.orgFish not Supplements: https://echochildren.org/research-summaries/fish-but-not-supplements-consumed-in-pregnancy-associated-with-lower-rates-of-autism-diagnosis-and-related-traits-echo-cohort-study-finds/Other Resources:Biological Energy: Quantum Mechanisms, Water, DHA, and NF-kB (Autism is a loss of energy- electrons, photons, protons)https://youtu.be/2-IA_gunXbw0:00 Dr. Kristen Lyall2:30 Her Journey into Epidemiology & Autism7:50 The Role of Epidemiology & Autism12:15 Modifiable Risk Factors17:32 Dietary Influences on Autism Risk; Eat more FISH (DHA!)22:53 Assessing Exposure & Risk Factors32:35 Immune & Hormonal Factors in Autism; Cytokines & Inflammation39:17 The Impact of Acute Events during Pregnancy44:45 Air Pollution & its Effects in Neurodevelopment; Oxidative Stress48:14 Current & Future Research; ECHO & EARLI56:34 Reviews/Ratings, Contact InfoX: https://x.com/rps47586YouTube: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAHopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com

In this brief episode, we discuss keeping up in the classroom during teacher lecture. Specifically, we discuss the delays in sensory processing, taking notes, visual thinking, and some challenges with keeping up. This is a pressing issue for Autistics, and in my opinion, education needs to do better for the Autistic phenotype. Autism and Education https://youtu.be/zQpNtvS-tWwX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com

For today's episode, we discussing transferring energy from the environment across our biology. We discuss a few quantum theories, atoms, molecules, water, DHA, and NF-kB. Life on Earth is driven by energy from the environment, and this could be missed with humans, and especially with developmental problems like Autism.Water Podcast 1: Rubin, Kruse, Huberman https://www.youtube.com/watch?v=0lBAcUMGIeI&t=43sWater Podcast 2: Gulhane and Kruse (Light changes the Physics of Water !) https://www.youtube.com/watch?v=l9UbguvfpysWater Podcast 3: Gulhane and Kruse https://www.youtube.com/watch?v=W5w0WainlMMhttps://www.plefa.com/article/S0952-3278(12)00147-0/abstracthttps://pmc.ncbi.nlm.nih.gov/articles/PMC5793004/#:~:text=Electrons%20exist%20in%20all%20matter,role%20in%20oxidation%2Dreduction%20reactions.Quantum-coherent energy transfer: implications for biology and new energy technologies https://pmc.ncbi.nlm.nih.gov/articles/PMC3385675/#:~:text=In%20the%20simplest%20picture%2C%20quantum,transport%20at%20the%20molecular%20scale.Quantum cognition: The possibility of processing with nuclear spins in the brain https://www.sciencedirect.com/science/article/abs/pii/S0003491615003243Role of semiconductivity and ion transport in the electrical conduction of melanin https://www.pnas.org/doi/10.1073/pnas.11199481090:00 Intro0:40 Quantum Biology, Coherence, Thermodynamics, Water, DHA, NF-kB, and transferring energy - Atoms & Molecules2:00 Oxygen and CCO; Mitochondria3:55 Quantum Biology; Environments influence Atoms & Molecules5:50 Coherence & States; Light guides Life on Earth; Light provides Energy after it hits Matter7:16 Modern Human Environments7:41 Quantum Thermodynamics; Melanin, Electrons; Rules9:03 Biophotons, Photons and Lux; Seasonal Impact11:15 Electrons & Mitochondria; Real sources of Energy12:00 Artificial Light versus 280nm-3100nm Light; Big Harma & GLP-1 sidebar14:16 Autism and Loss of Biological Energy; changes in Light15:43 Electrons in Biology; Water; Coherent Domains; Semiconductors17:15 DHA; Electron Efficiency; Cells; Photoreceptors and Converting Energy and Developing Nervous Systems (plural)19:20 Phylogeny of Oxytocin and DHA sidebar; pi-electons; DHA dictates DNA22:40 Jack Kruse Quote23:36 Cells, Tissues, & Synapses; Origins of Autism; DHA roles26:14 Autism and X, Y, Z comorbid conditions (plural); definitions of Autism (modern versus origins), Criteria29:23 DHA takeaways; efficiency31:41 NF-kB; creating the womb and nervous systems; Autism and Orbitofrontal Cortex (OFC)35:06 Reviews/Rating & Contact Info

These are comments about my opinion and experience with education- the classroom and the school day. There are many contrasts to the Autistic phenotype when it comes to the classroom and school day.Autism and Education https://youtu.be/zQpNtvS-tWwB.3 https://youtu.be/Ov_Bw--zzrQKanner Kids https://youtu.be/FjELhG5FKzsAsperger's Autistic Intelligence https://youtu.be/qygNL6wCrhgX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com

For today's episode, Dr. Hanna Stevens joins me to discuss early prenatal factors of early brain development. Dr. Stevens received an MD and PhD in Neuroscience from the University of Illinois. Dr. Hanna Stevens leads the Psychiatry and Early Neurobiological Development Lab at the University of Iowa Carver College of Medicine. Dr. Stevens is a distinguished Professor of Psychiatry and holder of the Ida P. Haller Chair.Her work leads groundbreaking research into the molecular and cellular foundations of early brain development, and is pivotal in linking prenatal stress, environmental factors, and genetic influences on childhood behavior and the emergence of disorders. With a focus on the critical periods of pregnancy and early childhood, her research aims to revolutionize the diagnosis and treatment of conditions throughout the lifespan. By the end of this episode, we hope you receive valuable information about the Placenta, Womb, and Development.Dr. Hanna Stevens https://medicine.uiowa.edu/psychiatry/profile/hanna-stevensIowa Healthcare https://uihc.org/childrens/providers/hanna-e-stevensPsychiatry and Early Neurobiological Development Lab (PENDL) https://stevens.lab.uiowa.eduPublications https://stevens.lab.uiowa.edu/publications0:00 Dr. Hanna Stevens2:00 Journey into Neuroscience and Psychiatry8:13 Prenatal Development of Autism14:02 The significance of NF-kB in Brain Development23:10 Serotonin; Leukocytes as a window into our Biology; Cortisol29:02 Steroid Hormones and Stress & Development34:12 Methylation40:00 Cell Proliferation & Migration in Fetal Development; Antioxidants45:56 Oxidative Stress; Mitochondria; Antioxidants48:30 Quantum Biology/Physics** Me shaking my head at minute 48:50 is not intended at Dr. Stevens, but at myself because I tell myself not to keep going to the electrons and light for a Cause of Autism to guests53:19 Future Research & Dorsal Striatum; Volume; Brain Development1:00 Reviews/Rating; Contact InfoX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com

For today's episode, we go back to the origins of Autism. It seems necessary because of the recent shifts in what is Autism and the confusion in the rates of Autism. Autism was here in the 1930's, and it magically showed up in different areas of the world. The two-part series intends to remember the phenotypes that appeared and became known as Autism and Asperger's.It is my opinion, the recent shifts in defining Autism could be rooted in questionable intentions. Regardless, one goal of the podcast is understanding and explaining Autism. By the end of the episode, and by the end of the two-part series, I hope you gain understanding of the Autistic Phenotype.If the children described by Asperger in Autistic Psychopathy in Childhood were alive today, they would receive a smorgasbord of diagnosis.Introduction to the Podcast (00:00:00 - 00:00:41,320):Asperger's Work and Concept of Autism (00:00:41,320 - 00:02:21,040):Historical Context and Asperger vs. Kanner (00:02:21,040 - 00:05:10,520):Case Study: Fritz V. (00:05:45,080 - 00:11:25,920):Detailed case study of Fritz, highlighting social integration issues, motor delays, superior speech, and behavioral challenges.Discussion on how modern medicine might label Fritz with multiple diagnoses.Case Study: Harold L. (00:13:21,040 - 00:15:25,240):Description of Harold's struggles with school, social withdrawal, and the conflict between autistic capabilities and societal expectations.Case Study: Ernest (00:17:37,960 - 00:21:00,160):Ernest's case with normal development but severe academic struggles, social withdrawal, and unique learning styles, suggesting individual teaching methods for autistics.Case Study: Hellmuth L. (00:21:16,680 - 00:24:40,240):Helmuth's case with complications at birth, delayed development, obesity, and later sexual tendencies, linking these to environmental and light exposure changes.Common Features Across Asperger's Cases (00:24:49,600 - 00:26:29,720):Summary of common traits observed across Asperger's 200 cases, including eye gaze issues, peripheral vision, and social interaction patterns.Asperger's Insights on Autistic Intelligence (00:26:29,720 - 00:27:37,760):Discussion on the unique intelligence and original ideas in autistic children, introducing the concept of "Asperger's little professors."Reflection on Autism as a Phenotype vs. Disorder (00:27:37,760 - 00:29:12,680):Historical Figures and Autism (00:29:12,680 - 00:29:41,480):Speculation on whether historical geniuses might have had autistic traits, highlighting that autism could be viewed as a superpower in certain contexts.Conclusion (00:29:41,480 - 00:30:42,800):X: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com

For today's episode, we go back to the origins of Autism. It seems necessary because of the recent shifts in what is Autism and the confusion in the rates of Autism. Autism was here in the 1930's, and it magically showed up in different areas of the world. (Part 2 on Asperger's "little professors" next). The two-part series intends to remember the phenotypes that appeared and became known as Autism.It is my opinion, the recent shifts in defining Autism could be rooted in questionable intentions. Regardless, one goal of the podcast is understanding and explaining Autism. By the end of the episode, and by the end of the two-part series, I hope you gain understanding of the Autistic Phenotype.Leo Kanner: Autistic Disturbances of Affective Contact http://www.autismtruths.org/pdf/Autistic%20Disturbances%20of%20Affective%20Contact%20-%20Leo%20Kanner.pdf0:00 Intro0:45 Erwin Schrödinger Quote; Quantum Physics; Missing link in Medicine2:56 Kanner's Autistic Disturbances of Affective Contact; Demographics3:52 Ages; Boys versus Girls; Phenotypes; Family History6:26 Important consideration of Family History- electricity and nnEMF; general observation and important phenotypes9:30 Anticipatory Motor Adjustment; Reflexes; Sensory and Adaptive Responses13:32 Monotonous Repetitions; Sameness15:26 Spelling and Language18:20 Commands and Intrusions18:57 Autism, not Autism and ADHD; Intense Fixations & Neuroplasticity; Default Mode Network; Sameness24:00 Oblivious to Others; Inattentive- It's not ADHD, it's Autism27:39 Changes & More on Sameness & Repetitions30:10 Rote Memory; Gastrointestinal: Timelines and MilestonesX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com

For today's episode, Dr. Eric Weiss, MD, explains an exciting medical approach for Autism. Dr. Weiss, who holds board certification in Plastic and Reconstructive Surgery, is a notable figure in regenerative medicine. Dr. Weiss is a Veteran of the U.S. Navy. Dr. Weiss attended Duke University Medical School for his medical degree, completed his General Surgery Residency at the University of California, San Francisco (UCSF), and did his Plastic Surgery Residency at the University of Miami. He has a special interest in using regenerative therapies to address autism.Dr. Eric Weiss recounts his journey into innovative medical practices, moving away from conventional pharmaceutical treatments. As a father to Marston, his dedication to exploring treatments for autism stems from personal experience. Throughout his story, his enthusiasm for natural healing methods is evident. By the end of this episode, listeners should gain insight into a thoroughly researched medical intervention that's gaining traction in the autism community.Dr. Eric Weiss, MD: https://northfloridastemcells.comDr. Eric Weiss, MD: https://linktr.ee/neflpsEducating Marston: https://www.educatingmarston.comDisclaimer: This is not Medical Advice.0:00 Dr. Eric Weiss, MD1:55 Dr. Weiss's Medical Journey5:01 Intersection of Autism and Stem Cell Research12:09 Personal Experience as a Parent with Autism15:58 Understanding Umbilical Cord Blood Treatment22:39 The Process of Umbilical Cord Blood Donation25:55 The Science behind Stem Cell Healing32:31 Future of Regenerative Medicine34:24 Natural Healing and Lifestyle, Not Big Pharma36:56 Mitochondrial Function & Energy Production39:09 The Impact of Light on Health41:07 Understanding Inflammation & Modern Disease44:30 Stem Cell Therapy: Mechanisms & Effects48:41 The Future of Medicine: Beyond Pharmaceuticals54:14 Professional Transition into Stem Cell and Regenerative Therapy58:05 Exploring Cytokines & Interleukins; Patterns of Disease; Dr. Weiss's Contact Info1:07 Reviews/Ratings; Contact InfoX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com

For today's episode, Nicole Rincon, PA-C, returns to discuss the risks associated with Autism development. The conversation spans from before conception through to after birth. We'll explore how factors related to the mother can influence autism risk, and we'll look at specific tests and signs in the body (labs and biomarkers) that have been linked to Autism. Additionally, we'll cover environmental influences, dietary considerations, acute medical conditions and medications, seasonal patterns, and various other aspects to be mindful of.By the end of the episode, we hope you'll gain valuable insights to consider as you navigate pregnancy. Our goal is to educate listeners, especially those who are pregnant or planning to conceive, about these potential risk factors, equipping them with the knowledge to make informed decisions or to be more aware during these pivotal times.Nicole Rincon https://www.nicolerincon.com/nicole-rinconRossignol Medical Center https://rossignolmedicalcenter.com/doctors/nicole-rincon/TACA Info: https://tacanow.org/wp-content/uploads/2019/10/F-H-2-Nicole-Rincon-Beginning-Biomed.pdfTACA Talks: https://www.nicolerincon.com/videosX: https://x.com/NicoleRinconPAPublications https://rossignolmedicalcenter.com/articles-publications/#published-2024-2-articlesOther Resources: Autism and the Embryo, and expanding Artificial Light as a possible cause of Autismhttps://www.youtube.com/watch?v=NOVp4mIroug(See 18:36)https://www.youtube.com/watch?v=OtA-aMN7ziYDISCLAIMER: THIS IS NOT MEDICAL ADVICE.0:00 Nicole Rincon1:00 Understanding Pre-Pregnancy Risks4:02 Maternal Risks Factors for Autism6:53 Environmental Factors for Autism9:56 Alternatives to Common Medications12:58 The Role of Light & Seasonal Factors16:02 Serotonin & Autism18:56 Inflammation & Mitochondria22:08 Infections & Antibiotics25:08 Lab Work & Biomarkers for Maternal Health27:46 Tyrosine, Thyroid, & Iodine; Depression, Fatigue31:07 Folate & Methylation in Pregnancy; Autoimmune; Pregnancy Complications40:40 Amino Acids; Dietary Types & Autism; Personal Diets49:00 Eating Seasonally & Locally51:01 Post-Pregnancy Nutrition54:00 Breastfeeding versus Formula Feeding; Environmental Factors & Toxins, Plastics, Water1:00 The Role of Sunlight on Human Biology; Leptin & Hormones, Metabolism Accountant; Red Light1:02 Sun and Sunscreen; Beta-Endorphins, Cannabinoids, Hormones1:07 Concluding Thoughts on Health & FamilyX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com

Relationships are challenging.In this episode, we explore some of the Autistic phenotypes challenges in relationships. We discuss symptoms from criteria A are external and criteria B are internal, and how criteria B complicates the symptoms in criteria A. In addition, Autism is a comparison to social-norms, and this is a problem. Some environments/relationships discuss include peer-to-peer, romantic, and parent-child. To begin, we explain the mechanisms behind the speaker-receiver and the use of conveying speech in socialness.Before we begin, we cover a brief explanation of Speaker-Receiver and human communication. Dr. Theresa Regan episode https://youtu.be/aUhIreFd5swAutism and Adaptive Responses https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000658438095What is Autism: Criteria A https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000651048705The Roles of Oxytocin and Vasopressin in the Autistic Phenotype https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000660031273(0:00) Intro; Speaker-Receiver explanation when conveying speech(3:55) Unpredicableness in socialness; black and white thinking and context-dependent and adaptive responses; Metabolic energy/resources; Oxytocin and Serotonin(7:10) Biology that gives us Autism gives us complications to socialness and relationships; Sex-differences and socialness(8:40) Criteria A is external, Criteria B is internal; Sensory-Processing(10:32) B.2 and B.3 implicates socialness(16:58) Direct social interactions(22:26) Autism versus social norms; Romantic relationships(26:51) Do Autistics outgrow Autism?(28:04) Parenting(31:30) Cohabitating(32:28) Wrap Up(32:45) Reviews/Ratings and contact infoLinks: hopp.bio/fromthespectrumX: https://twitter.com/rps47586Email: info.fromthespectrum@gmail.com

For today's episode, we speak with Dr. Theresa Regan, PhD & CAS, about adolescents and adults with Autism. Dr. Regan is a neuropsychologist with over 25 years of experience serving adolescents, adults, and seniors in hospital settings. She is a Certified Autism Specialist and the Director of the OSF HealthCare Adult Diagnostic Autism Clinic. Dr. Regan has conducted over 1,000 assessments on adolescents and adults with Autism. Her expertise in brain-behavior relationships, adult and geriatric medical conditions, and autism has provided her with a unique set of qualifications for serving adults with autism.In addition to her clinical work, Dr. Regan is the author of Understanding Autism and the host of the podcast "Autism in the Adult." During the episode, Dr. Regan shares valuable tools and protocols for Autistics as we learn to navigate various responsibilities such as employment and relationships. Her role as a neuropsychologist offers her insights into alternative approaches beneficial for both Autistics and their friends, family, as well as in employment and educational settings.Dr. Theresa Regan https://www.adultandgeriatricautism.comOSF Healthcare https://www2.osfhealthcare.org/providers/theresa-regan-1602000Autism in the Adult https://open.spotify.com/show/2POoTBvzgPr0yIkU7dmw2m?si=31381356153f4903&nd=1&dlsi=8f401dc6fce54bb5Understanding Autism https://www.amazon.com/dp/B098KQKZT7?binding=kindle_edition&ref_=ast_author_bsi0:00 Dr. Theresa Regan1:42 Journey into Psychology and Autism7:20 Understanding Autism in Adults13:39 The Role of Self-Knowledge in Relationships19:47 Challenges faced by Adults with Autism25:32 Tools and Protocols for Regulation31:48 Navigating Employment37:54 The Importance of Self-Care and Balance43:35 Resources and Future Direction55:18 Reviews/Rating and Contact InfoX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com

In this episode, we discuss Autism with Nicole Rincon, PA-C from Rossignol Medical Center. Nicole Rincon is a board-certified Physician Assistant (PA-C) who specializes in Pediatric Special Needs, MAPS (Medical Academy of Pediatric Special Needs), Integrative, and Functional Medicine. At Rossignol Medical Center, she is actively involved in patient care, research, and educational content. Nicole adopts valuable holistic and patient-centered care approaches in her practice.Nicole also brings a deeply personal perspective to the discussion as a mother of children with regressive Autism. This personal journey has fueled her motivation to explore the complexities of Autism, leading her to Rossignol Medical Center. Prior to this, Nicole spent years in medical weight management, focusing on nutritional counseling and wellness supplementation. This background provides her with unique insights into the metabolic, gastrointestinal, and environmental factors influencing Autism.Disclaimer: This is not Medical AdviceNicole Rincon https://www.nicolerincon.com/nicole-rinconRossignol Medical Center https://rossignolmedicalcenter.com/doctors/nicole-rincon/TACA Info: https://tacanow.org/wp-content/uploads/2019/10/F-H-2-Nicole-Rincon-Beginning-Biomed.pdfTACA Talks: https://www.nicolerincon.com/videosX: https://x.com/NicoleRinconPAPublications https://rossignolmedicalcenter.com/articles-publications/#published-2024-2-articles0:00 Nicole Rincon2:07 Nicole's Personal and Professional Journey into Medicine and Autism; "Who's the guy in Charge?"12:30 Understanding Autism Trough Research and Interventions; Regression; Omegas and Toxins21:56 Functional Medicine Approach to Autism; Rossignol Medical Center25:07 Introduction to various Folate factors, Folate Receptor Antibodies, and Methylation30:36 The Role of Mitochondrial Dysfunction and the many Comorbid Conditions of Autism (Autism and X, Y, Z)36:02 Collaborative Approach at Rossignol Medical Center; Research Insights and Opportunities from Nicole's multiple roles42:22 Challenges with the Current Medical Paradigm44:09 Maternal Health and its Impact on Autism48:34 Investigating Autism Beyond Vaccines50:59 The Role of Light and Environment in Human Biology; Electrons and Magnetism53:26 Introduction to Nicole's Comprehensive Evaluation from a Functional Medicine Approach; Understanding the Patient and Upstream Dysfunctions1:02 Multifactorial Approach1:05 The Future of Medicine, integrating Functional and Patient Center Care1:13 Reviews/Ratings and Contact InfoX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com

For today's episode, we discuss Autism with J.D. Barker. J.D. is a New York Times and International Best-Selling Author. His debut novel, Forsaken, caught the attention of legendary Author, Stephen King, who allowed Barker to use one of his characters from Needful Things for Barker's debut novel. His writing career took off with The Fourth Monkey, which drew widespread attention, leading to a series of auctions and pre-empts for its publishing rights globally. Barker's style often involves intricate plots that blend psychological depth with supernatural or crime elements, appealing to fans of both horror and thriller genres.Barker's work expanded when he was approached by Bram Stoker's family to co-author a prequel to Dracula, titled Dracul, utilizing previously unpublished notes by Stoker. Barker is a frequent co-author with legendary writer, James Patterson. Listen to how Barker can create such vivid imagination with the characters he creates. In addition, Barker shares critical information on how he navigates such a prolific and successful writing career, often managing many projects with great efficiency. This episode provides critical insights on how the Autistic Phenotype can strive with their unique superpowers.J.D. Barker https://jdbarker.com/books/heavy-are-the-stones/J.D Barker and Christine Daigle's upcoming book in November, Heavy Are the Stones https://www.amazon.com/Heavy-Are-Stones-J-D-Barker-ebook/dp/B0D5RKLYPC/ref=sr_1_1?crid=2TRLN3LUMCEFA&dib=eyJ2IjoiMSJ9.FJj1OgrpA4iJyLa9pHJ9ZQ.GiVjyydPJtKVpMdmN0HupggAyTd0GcjUBJ9l5UUA6xM&dib_tag=se&keywords=heavy+are+the+stones+jd+barker&qid=1728672013&sprefix=jd+barker+heavy%2Caps%2C119&sr=8-1J.D. Barker Books https://www.amazon.com/s?k=JD+Barker&crid=18DBO8RHA8T05&sprefix=jd+barker%2Caps%2C111&ref=nb_sb_noss_1X: https://x.com/jdbarker0:00 JD Barker2:49 Early Years of Creativity, Books, & Understanding Autism; Trying to Fit-In; Following Rules, Black and White thinking versus Gray11:43 Superpowers of Writing as a Reflection, Creativity, & Intelligence of the Inner World15:00 Superpowers of Autism by Creating Catalogs: Patterns, Visual & Thinking in Pictures, & Creating Characters20:42 Balancing Life with Autism23:51 The Writing Bout; the Importance of Managing Energy to avoid Burnout35:42 Focusing on the Process, not the Outcome39:35 Stephen King's Blessing & Approval of Forsaken; the journey to meet King41:44 James Patterson Collaborations43:25 Bram Stoker & the Prequel to Dracula, Dracul; Superpower of the Autistic Brain example46:11 Recognizing Autism in Children49:11 Future work52:42 Review/Ratings & Contact InfoX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com

In this episode, we discuss Autism and the Default Mode Network. According to Lisa Feldman-Barrett, the Default Mode Network has many names because it has been discovered, named, rediscovered, and renamed many times. I do not disagree with the Science regarding Autism and the Default Mode Network. However, I disagree with the Interpretation of the Data. This IS our Default; our preferred state; the core of the Autistic Phenotype.After listening to this episode and understanding B.3, you can understand MOST of Autism. The only reason you cannot understand ALL of Autism from these two episodes is the amount of Phenotypes branching off of B.3 and our Default Mode. Autism IS preference for ALONENESS and SAMENESS. This minimizes sensations and distractions that interfere with our internal world. This state is NOT abnormal, how society interferes with it makes it abnormal.If you want more Autistics to ACHIEVE, then understand your interaction, interference, and interpretation of what YOU think Autism is provides the delta of how much we are prevented in life. This, of course, becomes slightly different the more profound the Autistic Phenotype is with that specific person.In this episode, we will explore the different brain regions and the goals of these regions as it relates to our phenotypes. We will get into some "Thinking in Picture" and thinking styles. This will be a good time because of a future guest on From the Spectrum Podcast discussing Autism and Creativity. This is exciting for me.Lisa Feldman-Barrett Core System (DMN) https://lisafeldmanbarrett.com/2017/02/05/core-systems/0:41 Research at UT-Austin and the Importance of the INFRARED LIGHT study with Autism5:48 Autism and the Default Mode Network (DMN); Buzzword in Science7:19 Humans and our Prediction Machine and Sensory Processing; Innate or Learned; Oxytocin in the Autistic Phenotype;9:36 History of DMN (from Lisa Feldman-Barrett) and the many names; Core Systems11:58 medial Prefrontal Cortex (covered in many episodes); roles, E/I, connectivity, Internal Calculators14:45 Posterior Cingulate Cortex (PCC); Self-Referential Thinking, Memory, Attention, Task-Switching and the harms of calling it ADHD18:03 Angular Gyrus; Language, Sensory Processing "Bee Movie" example, Mental Images, Narratives, Empathy21:12 Supplementing Relationships23:36 Sensation-Perception24:30 Precuneus; Self-Awareness, Episodic Memory, Prediction and Strategic Planning25:52 Social Cognition; Social Cues and Skills27:50 Autism and Anxiety- Avoidance, Breathing (Physiology), and Valence (how we feel)28:48 Internal Calculators; Metabolic Bank Account and Demands29:26 the DMN is a Misnomer and the Default (tendency, phenotype) of the Autistic33:04 Reviews/Ratings, Contact InfoX: https://twitter.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com

For today's episode, we discuss Autism with Dr. Yehezkel Ben-Ari. Dr. Ben-Ari is a pioneer in the field of human development with over five decades of academic and private research. He has over 520 publications with a strong passion for early detection and treatment of brain disorders. His work includes studying Human Development, Autism, Epilepsy, Parkinson's, and Brain Tumors. He is a leader in how science understands the roles GABA and Chloride during early development and the NCCK1 importer and KCC2 exporter during the Excitation/Inhibition shift.In 1986, he led INSERM Neurobiology and Pathophysiology of Development before shifting to Start-Up private investigation in 2008. He is the founder of Neurocholre, B & A Biomedical, B & A Oncomedical, INMED, and IBEN. Recently, Dr. Ben-Ari has made wonderful contributions towards Autism identification in the Placenta using the work of "Neuroarchaeology" and Machine Learning. Dr. Ben-Ari is the recipient of many awards including Grand Prix de l'INSERM, Grand Prix European Society of Epilepsy, and Grand Prix Gagne Van Heck Belgian National Scientific Research (FNRS), to name a few. His book, The First 1000 Days, will soon have an English version. Treating Autism with Bumetanide is available now.Dr. Yehezkel Ben-Ari https://www.inmed.fr/en/evenement/en-yehezkel-ben-ariNeurochlore https://www.neurochlore.fr/en/Machine Learning https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994821/Excitatory Actions of GABA https://www.nature.com/articles/nrn920GABA https://journals.physiology.org/doi/full/10.1152/physrev.00017.2006Neuro-Archaeology https://pubmed.ncbi.nlm.nih.gov/18951639/eBooks: https://www.amazon.com/s?k=yehezkel+ben-ari&crid=1LZK6JWEBG4NC&sprefix=yehezkel+ben-ari%2Caps%2C196&ref=nb_sb_noss0:00 Dr. Yehezkel Ben-Ari3:08 Understanding Autism: Origins and Early Detection8:08 The Roles of Machine Learning Data Analysis in Identification14:56 The Impact of Environment and Autism23:18 Treatment Approaches and Efficacy, Bumetanide, and NKKC1 Inhibitors31:04 Challenges in Autism Research, including the Genetic Debate, Medical Paradigms, and Decision-Makers38:00 Future Direction and Innovative Research, Autism in the Placenta and the Environment during Pregnancy53:56 Wrap Up / Reviews and Ratings, Contact InfoX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com

For today, just a brief introduction to research beginning at UT-Austin, University of Texas at Austin, led by Dr. Francisco Gonzalez-Lima. The study is called: Effects of Transcranial Infrared Light Stimulation on Symptoms of Autism Spectrum Disorder. In the link below, it is Study #2. Dr. Francisco Gonzalez-Lima https://dellmed.utexas.edu/directory/francisco-gonzalez-limaResearch Link (Study #2) https://labs.la.utexas.edu/gonzalez-lima/participate-in-our-research/Research Team https://labs.la.utexas.edu/gonzalez-lima/team/X: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com

In this episode, we discuss eye-tracking as an early biomarker for Autism. Eye-tracking, on infants, improve assessment outcomes at young ages, as young as 14-months-old. Adding biomarkers to the assessment process is valuable, and Autism research is beginning to offer more biomarkers. We've covered biomarkers in cellular respiration, serotonin, two studies on 6-week-olds- 1) predicted profound Autism with brain cortical organoids and 2) salience network connectivity. Today, we review four scientific papers on eye-tracking being added to the assessment process. A valuable consideration is the roles our eyes have on brain development, which we cover as well. Pierce et al 2019 https://pubmed.ncbi.nlm.nih.gov/31034004/Wen et al 2022 https://www.nature.com/articles/s41598-022-08102-6Keehn et al 2024 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2818669Early Autism Evaluation (EAE) https://medicine.iu.edu/expertise/indiana-health/access-to-care/autism/careRudling et al 2024 https://journals.sagepub.com/doi/full/10.1177/13623613231203037The Roles of Oxytocin and Vasopressin in the Autistic Phenotype https://www.youtube.com/watch?v=DAtmC-s1_e00:00 Intro; 2 studies on 6-week-olds; Eye Development and Brain Development, Opsins5:23 OCT (Optical Coherence Tomography) scans and Brain predictors, Melanopsin and Choroid Plexus 7:06 Melanin and Melanopsin through the body and biochemistry8:39 Fruit Tree Example from Dr. Kruse9:29 Eye-tracking and Autism as a Biomarker; Neuroplasticity- Human's capacity to think; Autism is NEW in human evolution14:05 Social Attention; Oxytocin- magnocellular and parvocellular; Objects over People; Gaze Following 17:21 Gaze Attention 18:02 Joint Attention 19:12 Studies on Infants; Pierce et al, 201925:00 Wen et al, 202227:03 Keehn et al, 2024 and Early Autism Evaluations (EAE) 29:25 Rudling et al, 202432:15 Wrap-Up/Final Thoughts34:55 Reviews/Ratings, Contact InfoX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com

For this episode, we discuss the roles and sensitivity of mitochondria with Dr. Richard Frye, MD, PhD. Dr. Frye received an MD and a PhD in Physiology and Biophysics from Georgetown University. He is board certified in Pediatrics, Neurology with special competence in Child Neurology, and as a Certified Principal Investigator. In addition, he has a Masters in Biomedical Sciences and Biostatistics from Drexel University. Dr. Frye has over 300 publications in leading journals and book chapters.He currently sees patients as a Neurologists and Director of Research at Rossingnol Medical Center and at Neurodevelopmental Precision Medicine. In 2022, Dr. Frye co-founded the Autism Discovery and Treatment Foundation where they are dedicated to discover biomarkers, metabolic endophenotypes, and treatments for neurodevelopemental disorders.Dr. Frye shares many figures during the conversation so the listener can follow along.Dr, Richard Frye https://drfryemdphd.comCV https://wparticles.seek2understand.org/wp-content/uploads/2023/02/DrFryeCVJan2023.pdfRossingnol Medical Center Facebook https://www.facebook.com/RossignolMedicalCenterNeurobiology of Disease 2024 paper https://www.sciencedirect.com/science/article/pii/S0969996124001190?via%3DihubAutism and GI, and exploring how changes in Light have major implications (Apple) https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000664349495 0:00 Dr. Richard Frye6:13 Intro into mitochondria & energy production, various disease & dysfunction11:16 Mitochondrial DNA, sensitivity, and the roles with epigenetics16:16 Biomarkers of mitochondrial dysfunction, delicate delivery (space and time) into the electron transport chain20:58 Cytochrome C Oxidase (complex IV); Carnitine, Fat, and Creatine26:57 Molecules connected to aging & cellular respiration, environemental signals implicating mitochondria30:26 Terrible Trio: oxidative stress, mitochondria dysfunction, immune/inflammation, DAMPS & inflammation34:29 Environmental risks for the Embryo, overreactivity of mitochondria (200%) and physiological insults and regression42:50 Tryptophan (aromatic amino acid), NAD, and Gastrointestinal biosynthesis45:52 Light as an environmental change factoring into the Autistic Phenotype, Infant Tree and Adult Tree examples; Vitamin D (skin & brain are connected through Neuroectoderm)54:54 Future Research59:58 Wrap up, Reviews/RatingsX: https://twitter.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com

In this episode, we discuss the mitochondria. You know mitochondria as the "powerhouse" of the cell, but this biological process is biophysics meeting biochemistry. We discuss glycolysis, the TCA cycle (or Citric Acid cycle or Krebs cycle), and Oxidative Phosphorylation. This discussion goes deep inside the atomic molecular level with electrons and protons. Hang in there with the discussion and topic of Autism and understanding of the generational link to a loss of electrons. Jack Kruse https://www.patreon.com/DrJackKruse/postsGlycolysis https://www.ncbi.nlm.nih.gov/books/NBK470170/#:~:text=Glycolysis%20is%20a%20central%20metabolic,use%20in%20other%20metabolic%20pathways.Citric Acid cycle https://en.wikipedia.org/wiki/Citric_acid_cycleOxidative Phosphorylation https://en.wikipedia.org/wiki/Oxidative_phosphorylation0:00 Intro; Light, water, magnetism; The "powerhouse" and understanding of healthy living organisms and different cell types; Photosynthesis and Cell Respiration 4:11 Prokaryotes, Eukaryotes, and Cytochrome C Oxidase (CCO)6:53 Mitochondria and Cellular Respiration 1) Glycolysis, 2) Citric Acid cycle, and 3) Oxidative Phosphorylation (OXPHOS) 8:25 Glycolysis10:03 Citric Acid cycle12:02 OXPHOS13:51 Cytochrome I15:07 Cytochrome II16:08 Cytochrome III17:10 Cytochrome IV and creating water19:56 Not all water is equal/same; Aging; Light and Melanin and Rates of Autism29:20 Cytochrome V and ATPase; Chromophores 33:56 Evolution and losing electrons; Autism and modern health complications37:50 Environmental signals due DNA sequencing; Autism research and Genetic studies40:23 Reviews/Ratings and contact infoX: https://twitter.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com

In this episode, we challenge the modern trend of Autism and ADHD comorbid diagnosis. We will use children from Kanner and Asperger to show these so-called ADHD symptoms are simply parts of the Autistic Phenotype. However, society finds it easier to lump these two conditions together, and we question why. We review both, the inattentive criteria and the hyperactivity and impulsivity of ADHD and explain when the Autistic phenotype exhibit these conditions.The criteria for ADHD are downstream behaviors seen across multiple reasons and act as a collect-all. I did not say ADHD does not exist, but I do say Autism and ADHD existing simultaneously seems unlikely if you really understand the phenotypes. Might it just be easier for society to lump these together instead of challenging the differences?B.3 and Inattention are complete opposites. Hyperactivity and Impulsivity can show up when anyone is in the wrong or horrible environment.Autism and ADHD https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918663/Leo Kanner http://www.autismtruths.org/pdf/Autistic%20Disturbances%20of%20Affective%20Contact%20-%20Leo%20Kanner.pdfHans Asperger https://psycnet.apa.org/record/1992-97284-0020:00 Intro; Brief Note on how environmental signals such as electromagnetic fields (EMF, i.e., Light) informs the genes on how to respond, and how disease manifests2:51 Autism and ADHD; Neurodiversity; and some problems in society7:58 Core of Autism- B.3, and Donald Triplett example; B.2 and Social Communication13:27 Autistic Phenotypes19:01 ADHD Phenotypes21:41 Specifiers and Lumping Contrasting Phenotypes33:18 Medication and ODD (Oppositional Defiant Disorder) Rant35:42 Autism conundrum with ADHD38:45 Reviews/Ratings and Contact InfoHopp: https://www.hopp.bio/fromthespectrumX: https://twitter.com/rps47586email: info.fromthespectrum@gmail.com

My guest today is Jonathan Mitchell. Jonathan is a senior citizen Autistic, Author of numerous novels and blogs, and stands up for the purpose of Autism. His blog, Autism Gadfly, provides perspectives of Autism otherwise not considered by the lay-public or researchers in Autism. Jonathan's views have been mentioned in Newsweek, NPR, Autism Daily Newscast, and HuffPost.Jonathan was born in 1955 in Los Angeles. We discuss his experience at an early age including psychoanalytic therapy, psychological assessment, and troubles through education. Eventually, Jonathan and his family learned about Autism while on a trip to the East. Jonathan faced many challenges through his education in different schools beginning in kindergarten. However, Jonathan graduated from UCLA with a bachelors of arts in psychology.We also discuss challenges in professional and personal life as an adult where he faced various barriers. In the early 2000s, when the internet allowed for different communication platforms, Jonathan began to call out things wrong in Autism. In addition, he carries a loud voice for a cure/treatment for Autism. Recently, you can find him on X as he continues to be a voice for the Autistic community.The Mu Rhythm Bluff https://www.amazon.com/Mu-Rhythm-Bluff-Jonathan-Mitchell-ebook/dp/B00BQN84GM/ref=sr_1_1?crid=2UHATAWKAT5YA&dib=eyJ2IjoiMSJ9.eocnp6hSIjLZqAuzxnIcPw.vv03H-Vx-BeqtHx4_dYo4W6QomZdOkuZ4JEBPgbA-IQ&dib_tag=se&keywords=the+mu+rhythm+bluff&qid=1724157644&sprefix=the+mu+rhy%2Caps%2C104&sr=8-1X: https://twitter.com/autismgadflyJonathan Mitchell website http://www.jonathans-stories.comWikipedia https://en.wikipedia.org/wiki/Jonathan_Mitchell_(writer)

Hans Asperger called the children "little professors"- This is Autism.In this episode, we explore criteria B.3, which is the core of Autism. Donald Triplett's father's first sentence to Leo Kanner- He seems self-satisfied.Leo Kanner http://www.autismtruths.org/pdf/Autistic%20Disturbances%20of%20Affective%20Contact%20-%20Leo%20Kanner.pdfHans Asperger https://psycnet.apa.org/record/1992-97284-002Erwin Schrödinger https://en.wikipedia.org/wiki/Erwin_Schrödinger0:00 Intro, Erwin Schrödinger and Leo Kanner; Light gives Life to Cells2:29 B.35:15 Hans Asperger, Autist7:19 Leo Kanner8:31 Paths to Superpowers; Autism and Education; Medicine and Charles Sidney Burwell13:50 Personal Experiences; Vietnam War; B.2 complications with B.315:22 Baseball Game and Probability16:52 Adult Examples17:55 1950s and Novel- example of Abnormal B.3; Thinking in Pictures and Supplementing Relationships21:29 Disruptions from unplanned or outside interference; Medication Approach and Warning23:36 Unusual Objects; ADHD prep; Finding interests in Life26:31 Check-Out lanes and Autism; Self-Satisified- This is Autism28:53 Circumscribed31:36 Perseverative; The Nervous System35:44 Bible; Inner-focus using B.3 as a Superpower and directing focus39:16 Dogs and Snakes39:50 Autistic Phenotype and B.3 at the Center40:30 Reviews/Ratings and Contact InfoX: https://twitter.com/rps47586Hopp: https://hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com