Podcast appearances and mentions of Neil Murphy

Our first full RAW and unedited episode for your listening pleasureIn this episode of the On the Runs podcast, hosts Eric and Erika welcome back Neil Murphy for a special edition focused on the 'Code Brown Commandments.' The conversation covers Neil's impressive achievements in running over the past year, including personal records and experiences during races. The trio delves into humorous and practical advice for runners, encapsulated in the Code Brown Commandments, which range from environmental responsibility to race day tips. The episode is filled with laughter, personal anecdotes, and valuable insights for both seasoned and novice runners. In this lively conversation, the hosts discuss various humorous and practical aspects of running, including the importance of packing essentials, the experience of using porta potties during races, and the significance of foot care. They touch on dating while running, the necessity of showing up for races, and the importance of companionship during long runs. The conversation is filled with anecdotes, tips, and light-hearted banter, making it both entertaining and informative for runners of all levels. In this lively conversation, Neil and Erika explore various humorous and serious aspects of running, including fashion faux pas, race day mishaps, and the importance of companionship. They share personal anecdotes about training, safety tips for runners, and the significance of maintaining a positive mindset. The discussion also touches on the perils of pre-run meals, the nightmare of chafing, and the importance of proper preparation for races. The episode concludes with reflections on the lessons learned and the camaraderie found in the running community.Chapters04:47 Neil's Year in Review: Achievements and Challenges11:48 Code Brown Commandments: The Beginning17:13 Humorous and Serious Commandments24:18 The Importance of Preparedness in Running29:57 Nip Care: The Importance of Preparation36:04 Bear Encounters: Facing Fears on the Run39:31 Running with Purpose: Lessons from Katherine Switzer44:55 Packing Essentials for Travel46:05 The Importance of Extra Underwear47:30 Injury Tales and Packing Wisdom48:45 Porta Potty Precautions52:00 Running Etiquette and Pooping Off the Path53:41 Foot Care and Running Tips57:00 Dating and Running: A Cautionary Tale59:28 The Power of Showing Up01:00:47 Pre-Run Rituals01:02:49 Embracing the Unexpected in Running01:04:23 Running Wisdom and Advice01:09:13 Ultra Running Commandments01:11:08 Comfort in the Wilderness01:14:05 Nutrition and Recovery Tips01:16:00 Setting Intentions for Races01:18:56 The Importance of Companionship01:21:15 Humor in the Midst of Challenges01:28:52 Humorous Anecdotes and Life Lessons01:32:00 The Importance of Preparation in Sports01:34:15 Pushing Beyond Limits: Personal Achievements01:38:41 Mindset and Motivation in Running01:47:18 Self-Talk and Mental Resilience01:48:55 Coping with Heat and Physical Challenges01:50:37 Training in Extreme Heat0Erika's Chicago Marathon Fundraiser - for American Foundation for Suicide Prevention in memory of her brother, Nick Strava GroupLinktree - Find everything hereInstagram - Follow us on the gram YouTube - Subscribe to our channel Patreon - Support usThreadsEmail us at OnTheRunsPod@gmail.com

The CPG Guys are joined by Art Sebastian, Founder & CEO of NexChapter, Jared Luskin, Head of Platform & Media Partnerships at Bridg and Neil Murphy, Chief Revenue Officer at Bridg.Bridg is a data and audience platform built exclusively for brick and mortar retailers and their CPG partners that powers retail media success. The platform solves a longstanding challenge – identifying and targeting in-store customers that aren't part of loyalty or rewards programs – using their exclusive offline resolution capabilities and clients' point of sale (POS) data. This episode is sponsored by BridgFollow Art Sebastian on LinkedIn here: https://www.linkedin.com/in/artsebastian/Follow NexChapter on LinkedIn here: https://www.linkedin.com/company/nexchapter/Follow NexChapter online here: https://www.nexchapterinc.com/Follow Jared Luskin on LinkedIn here: https://www.linkedin.com/in/jared-luskin/Follow Neil Murphy on LinkedIn here: https://www.linkedin.com/in/neil-murphy-49b940/Follow Bridg on LinkedIn here: https://www.linkedin.com/company/bridgplatform/Follow Bridg online here: https://www.bridg.com/Art, Jared & Neil answer these questions:How has the consumer perception of C-stores changed/shifted over time, and what factors have contributed to their growing popularity?What has been the challenge for convenience stores in terms of building a meaningful data asset to fuel the ability to create & measure audiences for use in retail media?We see that the typical focused c-store shopper is in and out in under four minutes––can you elaborate on some of their key characteristics and behaviors, and how c-stores can capitalize on their unique position to better serve the communities they are in?How are these stores leveraging loyalty programs and personalized programs today, particularly among fuel customers? What are the biggest areas of opportunity for brand advertisers to engage convenience shoppers in a measurable way and how do you see Rippl helping them to enable this opportunity?What key trends and innovations are shaping the future of convenience retail?them to enable this opportunity?CPG Guys Website: http://CPGguys.comFMCG Guys Website: http://FMCGguys.comCPG Scoop Website: http://CPGscoop.comDISCLAIMER: The content in this podcast episode is provided for general informational purposes only. By listening to our episode, you understand that no information contained in this episode should be construed as advice from CPGGUYS, LLC or the individual author, hosts, or guests, nor is it intended to be a substitute for research on any subject matter. Reference to any specific product or entity does not constitute an endorsement or recommendation by CPGGUYS, LLC. The views expressed by guests are their own and their appearance on the program does not imply an endorsement of them or any entity they represent. CPGGUYS LLC expressly disclaims any and all liability or responsibility for any direct, indirect, incidental, special, consequential or other damages arising out of any individual's use of, reference to, or inability to use this podcast or the information we presented in this podcast.

Send us a textUnlock the secrets to thriving in the evolving UK business analyst contract market with our insightful conversation featuring experts Pete Bagnall, Neil Murphy, and recruitment specialist Rory Wood from Investigo. We chat about how networking and personal connections are key in modern recruitment. Rory gives his insights on how keeping active on LinkedIn can boost your visibility and why personal recommendations often beat job site applications. We'll dive into the recruiter-business analyst relationship, focusing on empathy, specialisation, and strong client connections for consistent contract work and how the IR35 legislation is reshaping the role of interim contracts.Finally, we examine the future of recruitment through the lens of AI and remote work. Understand the balance between digital tools and in-person interactions, and ponder the intriguing possibilities AI presents in the hiring process. Whether you're a seasoned professional or new to the field, our discussion offers a view of the current trends and future directions in the recruitment world,Rory Wood: https://www.linkedin.com/in/rory-wood-268171134/Investigo: https://www.linkedin.com/company/investigo/PresentersNeil Murphy: https://www.linkedin.com/in/neil-murphy-1613601/Pete Bagnall: https://www.linkedin.com/in/petebagnall/

The CPG Guys are joined in this episode by Joell Robinson, Senior Director for Retail Media Sales & Activation at Giant Eagle & Neil Murphy Chief Revenue Officer at Bridg, a division of Cardlytics.This episode is sponsored by Bridg.Follow Joell Robinson on LinkedIn at: https://www.linkedin.com/in/joellguglielmo/       Follow Leap Retail Media Network online at: https://www.leapmediagroup.comFollow Neil Murphy on LinkedIn at: https://www.linkedin.com/in/neil-murphy-49b940?Follow Rippl Media Network online at: https://www.bridg.com/rippl-for-advertisersJoell & Neil answer these questions:As you seek to build out a meaningful retail media program, having a complete understanding of shoppers connected to transactions is fundamentally important. Would you elaborate on this and some of the challenges you face in this area?As you thought about seeking to resolve the identities of anonymous transactions, connecting them to Giant Eagle loyalty program members in order to further enrich Leap Media Group, what were important elements of your decision to partner with an external service provider?After deciding to partner with Bridg, what was the integration process like? How much effort on Giant Eagle's side did it take to activate the partnership and what were the KPIs you employed to evaluate the investment?In order to attract brands to invest in retail media, scale is a major consideration. How has Giant Eagle's recent announcement that it has entered the Rippl Data & Media Network enabled you to address the scale challenge that many regional & super-regional retailers have faced?How are brands able to leverage the Bridg-enhanced purchase behavior data of Giant Eagle shoppers to drive successful full funnel advertising outcomes?Where are you hoping to take the partnership with Bridg and what advice woul you give to other regional retailers looking to make their networks more appealing and accessible to brand advertisers?CPG Guys Website: http://CPGguys.comFMCG Guys Website: http://FMCGguys.comRhea Raj's Website: http://rhearaj.comLara Raj in the band Katseye debut: https://www.youtube.com/watch?v=bYg6aMDQ_TA   Kavita's podcast: Spotify  AppleDISCLAIMER: The content in this podcast episode is provided for general informational purposes only. By listening to our episode, you understand that no information contained in this episode should be construed as advice from CPGGUYS, LLC or the individual author, hosts, or guests, nor is it intended to be a substitute for research on any subject matter. Reference to any specific product or entity does not constitute an endorsement or recommendation by CPGGUYS, LLC. The views expressed by guests are their own and their app CPGGUYS LLC expressly disclaims any and all liability or responsibility for any direct, indirect, incidental, special, consequential or other damages arising out of any individual's use of, reference to, or inability to use this podcast or the information we presented in this podcast.

Ever wondered how the journey from a permanent Business Analyst role to a contracting position unfolds? Join us as Pete Bagnall and Neil Murphy, with nearly 40 years of combined experience, pull back the curtain on their professional paths through major companies like British Airways, Honda, and Lloyd's. You'll hear firsthand about the structured support, career progression, and learning opportunities that come with permanent roles. Discover how these environments nurture growth, allowing new BAs to spread their wings and make valuable mistakes safely. Neil's experiences at British Airways and Honda offer a glimpse into the supportive big office culture, while Pete shares how Lloyd's set the stage for his foundational growth.Switching gears, we dive into contracting, shedding light on the essential skills and mindset needed to thrive. Learn how to quickly adapt, deliver high-quality work, and master the art of networking, especially on LinkedIn. Pete and Neil discuss the practical challenges of contracting, from self-management to financial risks, and explore strategies to secure ongoing opportunities. Whether you're considering a shift from a permanent role or eager to understand the contracting lifestyle, this episode offers a wealth of insights and tips, underscoring that both career paths come with their own unique benefits and opportunities.

What happens when two seasoned professionals with over 40 years of combined experience face off in the classic Waterfall versus Agile debate? Join us, Pete Bagnell and Neil Murphy, as we share our personal journeys from Waterfall's rigid structure to Agile's dynamic flexibility. 

On this episode, Eric Langdon and Neil Murphy recap the Spartan New Jersey Ultra . This year was one of the harder years for this race, despite that Neil and Eric both made it on the podium for their Age Group. Oh, and of course we talk about the Killington Ultra, as well, since Neil has never missed a year there. Check out the OCR Discord if you haven't already! https://discord.gg/ocr

The CPG Guys are joined for this episode by Neil Murphy, Chief Revenue Officer at Bridg, a data and audience platform built exclusively for brick and mortar retailers and their CPG partners that powers retail media success. The platform solves a longstanding challenge – identifying and targeting in-store customers that aren't part of loyalty or rewards programs – using our exclusive offline resolution capabilities and clients' point of sale (POS) data. This episode is sponsored by Bridg.Follow Neil Murphy on LinkedIn at: https://www.linkedin.com/in/neil-murphy-49b940/Follow Bridg on LinkedIn at: https://www.linkedin.com/company/bridgplatform/Follow Bridg online at: https://www.bridg.com/Neil answered these questions:Let's dig into some of your pivotal career moments and how you came to join Bridg?Now walk me through what types of companies or archetypes at these companies are most in need of this solution.What sets you apart from the competition? There are so many data platforms out there - what makes Bridg so unique?Can you share more about your clients and how they are using Bridg today?Let's say a retailer or a brand wanted to get started, how would they go about it? What is the entry point for working with you?Looking into the future - what do you see coming? Transformative in the future and how as an organization tackle this?CPG Guys Website: http://CPGguys.comFMCG Guys Website: http://FMCGguys.comCPG Scoop Website: http://CPGscoop.comNextUp Website: http://NextUpisnow.org/cpgguysRetailWit Website: http://retailwit.comRhea Raj's Website: http://rhearaj.comKavita's podcast: Spotify   AppleDISCLAIMER: The content in this podcast episode is provided for general informational purposes only. By listening to our episode, you understand that no information contained in this episode should be construed as advice from CPGGUYS, LLC or the individual author, hosts, or guests, nor is it intended to be a substitute for research on any subject matter. Reference to any specific product or entity does not constitute an endorsement or recommendation by CPGGUYS, LLC. The views expressed by guests are their own and their appearance on the program does not imply an endorsement of them or any entity they represent.  CPGGUYS LLC expressly disclaims any and all liability or responsibility for any direct, indirect, incidental, special, consequential or other damages arising out of any individual's use of, reference to, or inability to use this podcast or the information we presented in this podcast.

Daytona 500 Champion (hose puller), Ryan Painter joins us on the Pod (00:23:30) this week. Ryan shares stories from his racing career on pit road and his recent foray into running events from little events to 70.3 Ironmans.  Ryan and Knute were teammates years ago when they worked pit road in the minor leagues of NASCAR chasing the dream. One of us is still kicking ass at the dream winning at tracks like Daytona and Indy, the other is a co-host of this podcast. Ryan shares many stories with us, stories of Knute never heard before on the Pod. Ryan also shares his running stories, from getting fired for running in a half marathon to his recent 70.3 Ironman. Ryan has worked hard and grinded for everything he's got. This is an episode that we really think you're going to enjoy. In the Tros Knute and Erika discuss their Super Bowl bet and the possibility of donating to charity. They also share their thoughts on fundraising and supporting friends' causes. Knute then recounts a recent house fire incident and his experience fighting the fire. They discuss the importance of fire safety and the need for proper precautions. Finally, Erika shares her vacation plans to Palm Desert.  They congratulate ultra runners John Calabrese and Neil Murphy on their recent achievements.  They then share the sad news of the passing of Kelvin Kiptum. They reflect on recent celebrity deaths, including Carl Weathers and Toby Keith and one of Knute's favorite hockey players from his childhood, Blaine Lacher, and offer their condolences to the friends and families of all 4 of them. Justine's Boston Marathon Fundraising PageLindsey's Boston Marathon Fundraising PageJaye's Boston Marathon Fundraising Page Strava GroupLinktree - Find everything hereInstagram - Follow us on the gram YouTube - Subscribe to our channel Patreon - Support us ThreadsEmail us at OnTheRunsPod@gmail.com

In this special edition of "The Outro", Knute and Erika discuss various topics, including the recent episode with Neil Murphy, playing Pokemon Go, the Western States lottery drawing, Mikala Shremshock's selection for the race, and Knute's training progress. They also talk about the new rail trail in Manchester and the need for a tunnel in the Derry Rail Trail. The episode concludes with Knute's encounter with Scott Black. In this episode, Erika and Knute discuss their nerves about the Chicago drawing and the logistical planning involved if they get in. They also talk about balancing multiple races and events, including their desire for a PR in Chicago. They share their uncertainty about future plans and their upcoming break. Knute talks about his home improvement projects, and they discuss engaging with listeners and reviews. They reflect on the impact of the podcast on listeners and share their plans for a Christmas special and end-of-year recap. They end with holiday wishes and a reminder to stretch.TakeawaysThe podcast celebrates 85 episodes and two years of existence.Erika enjoys playing Pokemon Go and shares her experience with the game.Michaela Shremshock is selected for the Western States race.Knute wins a raffle for Peak Recovery and plans to try cryotherapy.The need for a tunnel in the Derry Rail Trail is discussed. The anticipation and nerves surrounding the Chicago drawingThe importance of logistical planning for races and eventsBalancing multiple races and events can be challengingDesire for a personal record in a raceUncertainty about future plans and balancing commitmentsTaking a break and focusing on self-careEngaging with listeners and appreciating their supportThe impact of the podcast on listenersPlans for a Christmas special and end-of-year recapHoliday wishes and a reminder to stretchJaye's Boston Marathon Fundraising PageJustine's Boston Marathon Fundraising Page Linktree - Find everything hereInstagram - Follow us on the gram YouTube - Subscribe to our channel Patreon - Support us Email us at OnTheRunsPod@gmail.com

Neil is back! A listener favorite back in 2022, A Florida Man with the perfect gut to hold a slice of Pizza and hair that could rival Thor! He's a legend in the Spartans community who can carry the boats and stays hard the entire time. He likes to embrace poop flumes from a porta potty to warm his thin Florida blood. The creator of Blow Gurt that will clear our your digestive system and he back to clear out Erika's sinuses for our final episode of the year, Neil Murphy, welcome back to the On The Runs Podcast. Neil and Erika discuss various topics related to ultra running. They talk about the quirks and unique habits of ultra runners, including Neil's love for cheese and Erika's fascination with targeted ads. They also discuss training strategies, nutrition, and the importance of trying new things during long runs. Neil shares his aspirations to participate in races like Badwater and the challenges he faces in qualifying for them. The conversation ends with a lighthearted discussion about Neil's cat and future race plans.This episode had no limits! Off The Rails, minimal editing, raw dog sandpaper no lube finish! Listen at your own discretion. TakeawaysUltra runners have unique quirks and habits that help them during races.Targeted ads can be both amusing and invasive.Trying new foods and strategies during training runs can help determine what works best for an individual.Participating in ultra races requires dedication, training, and a love for pushing one's limits.Having a supportive crew and a sense of humor can make the ultra running experience more enjoyable.The outro will drop on Thursdays this week!Jaye's Boston Marathon Fundraising PageJustine's Boston Marathon Fundraising Page Linktree - Find everything hereInstagram - Follow us on the gram YouTube - Subscribe to our channel Patreon - Support us Email us at OnTheRunsPod@gmail.com

On this Episode , Neil Murphy and I recap the Spartan Killington Ultra. We go over the whole race, the different experiences we had, and what we thought about it this year. We talk about strategies, training, nutrition and the mindset for this race, as well. It was an amazing race this weekend! If you did the race, or you're thinking about it, check this Episode out!

On this Episode, Neil Murphy and I talk all things Killington Ultra! Neil has done every Spartan Ultra at Killington Vermont! We talk about pace strategy, fueling, and transition. We talk about the map, the climbs, the difference between last year's map, and this year's map. We talk about the bad weather that's rolling in, and much more. If you are doing Killington this weekend, or you're thinking about it in the future, you need to listen to this Episode!

Hope everyone is enjoying their 4th of July week. We're taking the week off, Eric is off the grid camping and Erika is doing something fun out there. But we won't leave you hanging. Check out this OTR Classic from episode 19, Neil Murphy / Pizza Gut. You'll be sure to laugh so hard you head hurts, your eyes will be tearing and snot coming out of your nose that your sinus system will be cleared out by the end of it. Linktree - Find everything hereInstagram - Follow us on the gram YouTube - Subscribe to our channel Patreon - Support us Email us at OnTheRunsPod@gmail.com

PJ talks to Neil about a shop with a special place in the hearts of Corkonians Hosted on Acast. See acast.com/privacy for more information.

PJ chats with Neil Murphy as we say a sad farewell to one of Cork's best loved shops. Andrew Geary on the strain caused by fighting for a proper education of his son. Coach parking not right on Lower Glanmire Road? And more... Hosted on Acast. See acast.com/privacy for more information.

The Georgia Death Race is one of those legendary races on the East Coast, it's a point-to-point 70ish mile race through the North Georgia mountains. On the chat, we've got Matthew Johnson from Georgia, Josh Lockwood, and Mr. Pizza Gut himself... Neil Murphy. Matthew Johnson is a guy who I've ran against before and these North Georgia mountains are his home terf. He's done races like the FATS 50k, the Sky to Summit, Sweet H2O, and the Quest for the Crest. Josh Lockwood was done races like the Long Haul 100, the Pinellas Trail Challenge, Whispering Pines, and Death at Depuis! Neil Murphy has now been out to the Georgia Death Race 8 times between volunteering and racing! His 2017 go at the race left him famous for the Pizza Gut meme. Whether know him has the Pizza Gut Guy, or not... He's done races like the Vermont Spartan Ultra Beast, Forgotten Florida 100, Spartan Death Race, and the No Business 100! The Georgia Death Race is a 74ish mile point-to-point race from Byron Herbert Reece Farm in Blairsville, Ga to Amicalola Falls State Park. The race has 16,000 ft of climbing and 16,000 ft of descent. It is relentless. 

Welcome to episode 119 [originally broadcast on Wednesday 15 March 2023] of #mhTV​​​​​​​​. Between 13 and 14 March the 2023 Horatio Congress happened in Malta. Dr Neil Murphy and Dave Munday attended on behalf of Unite/MHNA. In this episode, Neil and Dave provide a brief reflection on some of the highlights from the two day event. Following this you can see a recording of the congress session that Dave gave, joined by Nicky Lambert via Zoom: ‘#mhTV – how to build an online digital community'. We were also lucky to have the excellent volunteer, Shuna Vanner take up the ask to join in the conference session. Shuna is a clinical nurse specialist in Heiloo, Netherlands. Background: Mental ill health is still seen as frightening or mysterious, although it's part of everyday human experience. The community of people who live with mental distress, who care for and about them, who work to make things easier through research, practice and education have move in common than divides them and there is much to be understood and celebrated. During the pandemic and in their own time, the #mhTV team created an online television and podcast series to support colleagues, celebrate nursing and discuss mental health issues. We began by live streaming their conversations about COVID-19 on Facebook and covered mor- al injury, bereavement, loss and social inequality and have gone on to produce a 100 episodes about all aspects of mental health practice. Aim: To share our experience of coproducing a learning network and collaborating to produce educational and professional content Method: This is a shared and coproduced endeavour - we meet guests and engage in helping conversations to make complex ideas or intimidating topics accessible and interesting - we share links to work, articles, im- ages and support independent learning during the show and can respond to real time questions. We want to share our love of mental health communities and believe that you don't need permission to educate yourself or explore subjects you find interesting. For example the team also hosted the mental health nursing research conference enabling it to go ahead free of charge and expanding its reach to be seen by more than 2,000 people compared to its usual 200 attendees. Results and Discussion: In this workshop we will describe what we did and why. We will look at the successes and lessons learned and offer practical suggestions and guidance for anyone wishing to try something similar. We will also describe the technology used and how to get the most out of social media from a professional perspective. Some useful links: - Horatio: European Psychiatric Nurses website: https://www.horatio-eu.com - The Horatio Congress website: https://www.horatiocongress2023.com - An Unite/MHNA Twitter thread from #HoratioCongress2023: https://twitter.com/Unite_MHNA/status/1635192459310530560?s=20 Some Twitter links to follow are: VG - www.twitter.com/VanessaRNMH NL - www.twitter.com/niadla​​​​​​​​ DM - www.twitter.com/davidamunday Horatio: https://twitter.com/Horatio_eu Credits: #mhTV Presenters: Vanessa Gilmartin, Nicky Lambert & David Munday Guests: Dr Neil Murphy & Shauna Vanner Theme music: Tony Gillam Production & Editing: David Munday

On the Runs is taking some time during the holidays and we thought this would be a great time to share with you some of our favorite moments from the past year. Part 2 has a double dose of Neil Murphy from our Pizza Gut episode. Scott Black's Road to Kona had a rough go at Cozumel. We talk to the Beeman as Mike talks about his comeback journey just before the Boston Marathon Bombing in 2013 and Tara Watt code brown stories made the cut as they were too good to pass up. We got an exciting lineup for year two and we'll be back just after the new years!4:00 Neil Murphy 117:00 Scott Black Cozumel42:40 Eric lost his new watch46:52 Mike Beeman1:06:36 Tara Watt1:16:31 Neil Murphy 2

Are you prepared for the warmth of poop flumes coming from a porta potty? On this episode of On The Runs there are no details spared as we get to know Neil Murphy and the legend of Pizza Gut! Neil covers DNF's, staying hard, fitfluencers,  beard juice, blowgurt and more in this epic interview that had Erika's lungs out of air and blowing snot rockets on her shirt while Eric was  chugging Pedialyte just trying to stay alive.You've had 18 episodes so far, we've tried to prepare you for what's to come and it's here. 

In this weeks episode, we talk with pilot Neil Murphy about his father, Captain Mike Murphy, who died on May 25th, 2019. In late 2018, his Dad was diagnosed with an aggressive brain tumour, a glioblastoma. On May 25th 2019, 2 days before Neil's 27th birthday, his Dad had passed away. According to Neil, his Dad is the sole reason he is in an aviation career, and he couldn't have asked for a better role model. For that reason, this won't be any ordinary marathon. He wants this to be the most challenging 42.2km he could endure around London. The current record for a marathon dressed as a 3D aircraft is 5:03:15, and he hopes to beat this.So with your help, he can reach his fundraising target, and some precious funds can go towards a charity that is doing incredible work to help us understand more about this terrible cancer.DONATE HERE: https://uk.virginmoneygiving.com/NeilLondon2021 See acast.com/privacy for privacy and opt-out information.

Anti-aging compound improves muscle glucose metabolism in people Washington University School of Medicine in St. Louis, April 26, 2021   A natural compound previously demonstrated to counteract aspects of aging and improve metabolic health in mice has clinically relevant effects in people, according to new research at Washington University School of Medicine in St. Louis. A small clinical trial of postmenopausal women with prediabetes shows that the compound NMN (nicotinamide mononucleotide) improved the ability of insulin to increase glucose uptake in skeletal muscle, which often is abnormal in people with obesity, prediabetes or Type 2 diabetes. NMN also improved expression of genes that are involved in muscle structure and remodeling. However, the treatment did not lower blood glucose or blood pressure, improve blood lipid profile, increase insulin sensitivity in the liver, reduce fat in the liver or decrease circulating markers of inflammation as seen in mice. The study, published online April 22 in the journal Science, is the first randomized clinical trial to look at the metabolic effects of NMN administration in people. Among the women in the study, 13 received 250 mg of NMN orally every day for 10 weeks, and 12 were given an inactive placebo every day over the same period. "Although our study shows a beneficial effect of NMN in skeletal muscle, it is premature to make any clinical recommendations based on the results from our study," said senior investigator Samuel Klein, MD, the William H. Danforth Professor of Medicine and Nutritional Science and director of the Center for Human Nutrition. "Normally, when a treatment improves insulin sensitivity in skeletal muscle, as is observed with weight loss or some diabetes medications, there also are related improvements in other markers of metabolic health, which we did not detect in our study participants." The remarkable beneficial effects of NMN in rodents have led several companies in Japan, China and in the U.S. to market the compound as a dietary supplement or a neutraceutical. The U.S. Food and Drug Administration is not authorized to review dietary supplement products for safety and effectiveness before they are marketed, and many people in the U.S. and around the world now take NMN despite the lack of evidence to show clinical benefits in people. The researchers studied 25 postmenopausal women who had prediabetes, meaning they had higher than normal blood sugar levels, but the levels were not high enough to be diagnosed as having diabetes. Women were enrolled in this trial because mouse studies showed NMN had the greatest effects in female mice. NMN is involved in producing an important compound in all cells, called nicotinamide adenine dinucleotide (NAD). NAD plays a vital role in keeping animals healthy. Levels of NAD decline with age in a broad range of animals, including humans, and the compound has been shown to contribute to a variety of aging-associated problems, including insulin resistance in studies conducted in mice. Supplementing animals with NMN slows and ameliorates age-related decline in the function of many tissues in the body.  Co-investigator Shin-ichiro Imai, MD, PhD, a professor of developmental biology and of medicine who has been studying NMN for almost two decades and first reported on its benefits in mice said, "This is one step toward the development of an anti-aging intervention, though more research is needed to fully understand the cellular mechanisms responsible for the effects observed in skeletal muscle in people." Insulin enhances glucose uptake and storage in muscle, so people who are resistant to insulin are at increased risk for developing Type 2 diabetes. But the researchers caution that more studies are needed to determine whether NMN has beneficial effects in the prevention or management of prediabetes or diabetes in people. Klein and Imai are continuing to evaluate NMN in another trial involving men as well as women.     N-acetylcysteine for depression in adolescents and young adults at risk for bipolar disorder University of Cincinnati, April 23, 2021 According to news reporting originating from Cincinnati, Ohio, by NewsRx correspondents, research stated, “To investigate the mechanism of action of N-acetylcysteine (NAC) in depressive symptoms in young individuals at familial risk for bipolar disorder. We conducted an 8-week open label clinical trial of NAC 2400 mg/days in 15-24 years old depressed offspring of a bipolar I disorder parent, with baseline and endpoint proton magnetic resonance spectroscopy acquired within the left ventrolateral prefrontal cortex (VLPFC).” Our news editors obtained a quote from the research from the University of Cincinnati, “Nine participants were enrolled and finished the study. NAC significantly improved depressive and anxiety symptom scores, and clinical global impression (all p< .001). There was a non-significant reduction in glutamate levels in the left VLPFC. Reduction in depressive symptom scores was positively associated with reduction in glutamate levels in the left VLPFC (p = .007).” According to the news editors, the research concluded: “This pilot study suggests that NAC might be efficacious for depressive symptoms in at-risk youth, and that its mechanism of action involves the modulation of glutamate in the left VLPFC.” This research has been peer-reviewed.     Soda consumption linked to accelerated aging and increased mortality risk University of California at San Francisco, April 26, 2021 A recent study by researcher from the University of California, San Francisco says that drinking soda can increase the risk of all-cause mortality and accelerate aging. The findings build on mounting evidence of the adverse effects drinking soda and other sugary beverages have on the body, which include obesity, Type 2 diabetes, heart disease, kidney disease, non-alcoholic fatty liver disease, dental caries and gout. The team collated data from the National Health and Examination Surveys, an annual program for assessing the health and nutrition of American adults and children. They gathered data from over 5,300 participants between 1999 and 2002, all of whom had no history of diabetes or cardiovascular disease.  In particular, they looked at stored DNA data from the participants – measuring telomere length and comparing it with their consumption of sugar-sweetened soda. The researchers found that those who regularly drank sugar-sweetened soda had shorter telomeres than those who didn’t. Research has shown that telomeres have been previously associated with lifespan. Having shorter telomere length, for instance, has been linked to cardiovascular disease, diabetes and even certain types of cancer. The team reported in their study that consuming even just eight ounces of soda every day can accelerate aging by nearly two years. Meanwhile, 20 ounces of soda can accelerate aging by up to 4.6 years when consumed daily. In fact, drinking sugar-sweetened soda can reduce telomere length at a rate similar to smoking. The UCSF study is also the first to link regular consumption of sugar-sweetened soda to telomere shortening. According to study co-author Elissa Epel, drinking sugar-sweetened soda adds strain to the body by metabolizing these sugars and accelerates cellular aging in tissues. “This finding held regardless of age, race, income and education level. Telomere shortening starts long before disease onset,” Epel added. ” Although we only studied adults here, it is possible that soda consumption is associated with telomere shortening in children, as well.” Sugary sodas linked to rising all-cause deaths In another study, European experts revealed that drinking sugary sodas and other sweetened drinks increases the risk of all-cause deaths. The researchers collected data from more than 450,000 individuals enrolled in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a large-scale cohort study for biochemical and genetic markers for cancer and other chronic diseases. A follow-up revealed that more than 40,000 participants from the original study had already died. Using their data, the team found a strong link between regular soda consumption and all-cause mortality. Those who regularly drank more than two glasses of sugary drinks increased their risk of dying from circulatory diseases, while those who drank at least one glass of sugary drinks increased their risk of dying from digestive diseases and Parkinson’s disease. “Our results … provide additional support for the possible adverse health effects of sugar-sweetened soft drinks and to replace them with other healthier beverages, preferably water,” explained co-author Neil Murphy. “For artificially-sweetened soft drinks, we now need a better understanding of the mechanisms that may underlie this association and research such as ours will hopefully stimulate these efforts.” The findings appeared in JAMA Internal Medicine.     Curcumin concoction could combat colitis: Study Baylor University, April 25, 2021 A formula that blends curcumin and turmeric oils can prove effective against the activity and inflammatory burden of colitis, a study has determined. Published in Nature Scientific Reports, the study identifies the efficacy of a specific curcumin preparation containing essential turmeric oils (ETO-curcumin) in reducing colitis symptoms. These turmeric oils, aromatic-tumerones (ar-tumerones), alpha-turmerones, beta-turmerones, alpha-santalene and aromatic curcumene, appear to be responsible for an anti-inflammatory and anti-oxidant action, the study suggests. The combination also appeared to exert higher bioactivity than stand-alone curcumin – a feature that could prove valuable in using turmeric for other intestinal conditions. “The therapeutic benefits of turmeric can be attained at its best by combining curcumin with turmerone, an active compound derived from essential oil of turmeric,” said P.J. Kunjachan, chairman and managing director for Arjuna Natural Extracts “This new finding provides our customers an added value for promoting their BCM-95-based formulations in an increasingly crowded curcumin market,” added Dr Benny Antony, joint managing director for Arjuna. BCM-95 often combines curcumin with other turmeric compounds as its poor bioavailability has been cited as a barrier to its use in other disorders. Obstacles are not limited to curcumin's chemical properties. Despite the 17 claims for its anti-inflammatory and digestive health properties, there are currently no approved health claims for curcumin in the EU. These claims are featured on the 2000+ list of on-hold botanical claims yet to be processed by the European Food Safety Authority (EFSA). As well as Arjuna, other manufacturers with an interest in curcumin include herbal manufacturers Sabinsa and Italian botanicals firm Indena. Led by Dr Shusuke Toden, research associate from Baylor University in the US, the trial compared ETO-curcumin preparations  against standard curcumin at three specific doses (0, 5, 25 or 50 milligrams per kilogram (mg/kg)). These doses were administered to an animal model with induced colitis for seven days. The research team found that ETO-curcumin improved disease activity index (DAI) dose-dependently, while the anti-inflammatory efficacy of standard curcumin remained constant. “This suggests that ETO-curcumin may provide superior anti-inflammatory efficacy compared to standard curcumin,” the study explained. “ETO-curcumin associated anti-inflammatory effects were particularly pronounced at higher doses.” Further findings revealed that anti-inflammatory proteins produced included IL-10 and IL-11 as well as FOXP3, which increased in number in the colon by ETO-curcumin.   Study examines association between lifestyle patterns and BMI in early childhood Results support obesity prevention efforts early in life Deakin University (Australia), April 26, 2021   A new Australian study reveals that changes in lifestyle patterns were longitudinally associated with concurrent changes in body mass index (BMI) z scores, and maternal pre-pregnancy BMI, maternal dietary patterns and television viewing time are significant determinants, according to a paper published online in Obesity, The Obesity Society's (TOS) flagship journal. This is the first study that used multi-trajectory modeling to examine the longitudinal relationship between concurrent changes in lifestyle patterns and BMI z scores in early childhood.  "The findings will inform early childhood obesity prevention intervention and policy, and will be of great interest to pediatricians, researchers, policymakers and the general public," said Miaobing Zheng of the Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, in Geelong, Australia. Zheng is the corresponding author of the study.  Experts explain that longitudinal studies investigating the association between lifestyle patterns and obesity in children are scarce. An association between a healthy lifestyle pattern and lower obesity risk has, however, been previously reported in a few cross-sectional studies. In the present study, the co-occurrence of stable healthy lifestyle patterns along with a concurrent normal BMI z score trajectory of one unit from 18 to 60 months in about half of the children provides new longitudinal evidence supporting that children with healthy lifestyles were more likely to concurrently have normal BMI z score development.  Data of 439 children were used from the Melbourne Feeding Activity and Nutrition Trial (InFANT) program. This longitudinal cohort of children commenced in 2008 as a 15-month parent-focused cluster randomized controlled trial aiming to reduce obesity risk behaviors in children until 18 months. Additional follow-ups without interventions occurred for children aged 42 and 60 months. Multi-trajectory modeling identified groups of children following similar lifestyle patterns and BMI z score trajectories and multi-nomial logistic regression assessed the determinants of the trajectory groups.  Three trajectory groups of child lifestyle patterns and BMI z scores were identified and distinguished, showing a mixture of healthy and unhealthy lifestyle behaviors and BMI zscores. Compared to Groups 1 "Unhealthy lifestyle pattern, Low BMI z" and 3 "Unhealthy lifestyle pattern, High BMI z", Group 2 "Healthy lifestyle pattern, Mid BMI z" revealed the most distinctive trajectories across lifestyle patterns and BMI z scores. Group 2 comprised nearly 53 percent of children and followed a stable and low trajectory for an unhealthy lifestyle pattern characterized by energy-dense and nutrient poor discretionary food consumption and television viewing time and a high and rising trajectory for a healthy lifestyle pattern of fruit and vegetable intakes and time outdoors, along with a mean BMI z score of +1 unit over time. Groups 1 and 3 shared similar high trajectories for an unhealthy lifestyle pattern of discretionary food consumption and television viewing time, and low trajectories for a healthy lifestyle pattern of fruit and vegetable intakes and time outdoors. The two groups however differed in BMI z score trajectories, showing stable patterns but at mean scores of 0 and +2 units, respectively. Child sex, breastfeeding duration and maternal physical activity were not associated with the identified trajectory groups. The study's authors note that the co-occurrence of stable lifestyle patterns and BMI z score trajectories in early childhood highlight the importance of initiating lifestyle obesity prevention early in life, and such interventions could target both children and the mother. A multi-behavior approach to simultaneously target healthy diet, physical activity and sedentary behaviors could be adapted. "Young children learn by imitating that which they see daily. There is no doubt that children copy the behaviors observed in the presence of parents: healthy and unhealthy," said Liliana Aguayo, PhD, MPH, a childhood obesity expert, TOS member and research assistant professor from the Hubert Department of Global Health at Emory University in Atlanta, Ga. "Evidence from this study highlights the importance of early childhood as a critical period for development of obesity. More research is needed to identify effective approaches to simultaneously address parent and child health behaviors." Aguayo was not associated with the research.     DDT exposure in grandmothers linked to obesity, earlier periods in granddaughters Young women today may face increased health risks linked to breast cancer due to effects from the banned toxic pesticide lasting over three generations University of California at Davis, April 16, 2021 In the first study to report on the health effects of exposure to a toxic environmental chemical over three human generations, a new study has found that granddaughters whose grandmothers were exposed to the pesticide DDT have higher rates of obesity and earlier first menstrual periods. This may increase the granddaughters' risk for breast cancer as well as high blood pressure, diabetes and other cardiometabolic diseases.  The research by the Public Health Institute's Child Health and Development Studies (CHDS) and the University of California at Davis was published today in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research. It suggests that effects from the pesticide DDT -- despite being banned in the U.S. nearly 50 years ago -- may contribute to the falling age of first periods and increases in obesity rates among young women today. The study found that the risk of obesity in young adult granddaughters was 2 to 3 times greater when their grandmothers (who were not overweight) had higher levels of o,p'-DDT (a contaminant of commercial DDT) in their blood during or just after pregnancy. Granddaughters were twice as likely to have earlier first menstrual periods when their grandmothers had higher o,p'-DDT blood levels. DDT and its related chemicals, including o,p'-DDT, are known to be endocrine disrupting chemicals, compounds that can alter and interfere with natural hormones that are essential for development.  "We already know that it's nearly impossible to avoid exposures to many common environmental chemicals that are endocrine disruptors. Now our study shows for the first time in people that environmental chemicals like DDT may also pose health threats to our grandchildren," said Barbara Cohn, director of CHDS and senior author of the study. "In combination with our on-going studies of DDT effects in the grandmother's and mother's generations, our work suggests we should take precautionary action on the use of other endocrine disrupting chemicals, given their potential to affect generations to come in ways we cannot anticipate today."  The Child Health and Development Studies is a unique project that has followed 20,000 pregnant women and their families for more than 60 years. CHDS enrolled and began following pregnant women in the Bay Area between 1959 and 1967, a time of high pesticide use before DDT was banned in 1972. These "founding grandmothers" in the study gave blood samples at each trimester during pregnancy and one sample shortly after birth. The blood samples were tested for levels of DDT and its related chemicals, including active ingredients, contaminants and their metabolites. The study today focused on o,p'-DDT as it has previously been linked to breast cancer, obesity and other harmful health effects in daughters, and is believed to be the most sensitive biomarker for exposures before and immediately after birth. Since granddaughters' exposure would occur via their mothers' in utero egg cell development, o,p'-DDT levels are a potential predictor of granddaughters' exposure outcomes.  "These data suggest that the disruption of endocrine systems by DDT initiates in immature human eggs, decades before the eggs are fertilized," said Michele La Merrill, associate professor at UCD who was co-lead author of the study. The CHDS study included interviews, home visits and questionnaires from the daughters and granddaughters of the original enrollees. During home visits, blood pressure and height and weight measurements were taken. The study today is based on 365 adult granddaughters who completed questionnaires, participated in a home visit, had available DDT measures from grandmothers' serum, and (for 285 of them) had available information on body mass index (BMI) in all three generations. Information on the age of first period for all three generations was available from 235 granddaughters. Previous CHDS studies have shown that mothers' DDT exposure during pregnancy or immediately after birth correlates with increased daughters' risk of breast cancer and the prevalence of breast cancer risk factors, including obesity, among adult daughters. Other prior studies have linked DDT exposure to birth defects, reduced fertility and an increased risk of diabetes. A commentary in the journal Reproductive Toxicology last year called CHDS "a national treasure that keeps on giving" and noted that "There are no other U.S. studies as well defined, sampled, and followed as the CHDS....The CHDS provides unique and essential value in understanding health effects of environmental exposures as they relate to life-stage sensitivity."       Capsaicin analog could help treatment-resistant lung cancer Small cell lung cancer cells exposed to synthetic analog of chili pepper compound responded better to chemotherapy Marshall University, April 27, 2021 A new study found that non-pungent synthetic analog of capsaicin -- the compound that makes chili peppers hot -- made small cell lung cancer cells more responsive to treatment. Small cell lung cancer is a very aggressive form of cancer with a low survival rate.  Cisplatin-based combination chemotherapy is typically the first-line treatment for small cell lung cancer patients. Although patients initially respond very well to this chemotherapy, the tumor usually comes back within a year in a form that doesn't respond to treatments. Patients with relapsed small cell lung cancer have very few treatment options.  "Irinotecan is the only FDA approved second-line drug for small cell lung cancer, but less than 3% of patients respond to it," said research team leader Piyali Dasgupta, PhD, from Marshall University. "Therefore, agents that improve the anti-cancer activity of irinotecan would be of great value to these patients." Jamie Friedman, a former doctoral student in Dasgupta's lab will present the new findings at the American Society for Investigative Pathology annual meeting during the virtual Experimental Biology (EB) 2021 meeting, to be held April 27-30.  The natural compound capsaicin has been shown to have anti-cancer effects, but its heat can also cause a burning sensation, stomach cramps, gut pain and nausea. In the new work, the researchers studied arvanil, a synthetic capsaicin analog without capsaicin's undesirable side effects.  When the researchers exposed two cisplatin-resistant lung cancer cell lines to a low concentration of arvanil, they saw no growth-inhibitory activity. However, when they treated the cells with varying concentrations of SN38 -- the active ingredient irinotecan -- they observed that the presence of arvanil greatly enhanced the ability of SN38 to slow cancer cell growth. Statistical analysis showed that the interaction between arvanil and SN38 was synergistic in nature.  "Because arvanil enhanced the anti-cancer activity of SN38 in human small cell lung cancer cells, arvanil-based combination therapies may be useful for patients with relapsed small cell lung cancer cells," said Friedman. "We hope that this work will pave the way for novel therapies for relapsed and cisplatin-resistant small cell lung cancer."     Five Therapeutic Properties of Medicinal Mushrooms GreenMedInfo, April 25, 2021   Mushrooms have recently gained popularity in culinary circles, but their far-reaching therapeutic properties should get your attention for a longer and healthier life. Although mushrooms have been part of the healer’s toolbox since ancient times, the medicinal power of mushrooms is gaining momentum in evidence-based journals. Medicinal mushrooms come in a wide variety and shapes such as white button, reishi, maitake, shiitake, oyster, cordyceps, cauliflower, tiger tail and lion’s mane, and most have health benefits that range from fighting cancer and boosting your immunity and memory to preventing diseases like diabetes and arthritis. 1. Anticancer Reishi (in Japanese) or lingzhi (in Chinese) mushrooms are well known in Asia for their anticancer properties. In a meta-analysis by scientists of 23 trials involving 4,246 cancer patients, reishi mushrooms enhanced longevity and quality of life in cancer patients.[i] Therapy with white button mushrooms impacted prostate-specific antigen (PSA) levels and inhibited prostate cancer by decreasing immunosuppressive factors.[ii] Polysaccharides from Cordyceps cicadae mushrooms inhibited the growth of cancer cells and induced cancer cell deaths showing its effectiveness as a low cost and safe treatment for cervical cancer.[iii] A peptide from the shiitake mushroom showed promising results in growth arrest, cell death and cleaning out damaged cells in a breast cancer in vitro study.[iv] In both in vitro and in vivo studies, results showed that mice with induced testicular cancer treated with the Cordyceps sinensis mushroom had significantly smaller and fewer tumors than the control group.[v] Cordyceps cicadae mushroom treatment prevented testicular damage and tumors caused by the chemotherapy drug cisplatin via inhibition of oxidative stress and inflammation in rats.[vi] In a lung cancer-induced study of mice, treatment with reishi mushrooms inhibited cell viability and mobility of lung cancer cells in vitro.[vii] In a cell study of reishi mushroom extract, the treatment offered high antitumor and liver protection with low toxicity on human liver cancer cells.[viii] 2. Immunomodulatory In a meta-analysis of 20 animal disease studies, grifola frondosa, or maitake mushroom, polysaccharide showed strong immune function by enhancing T cells, natural killer cells and macrophages in mice and increasing the secretion of two important immune factors, TNF-α and INF-γ.[ix] In a clinical study of 105 cancer patients undergoing chemotherapy or radiation treatments, a combination of reishi mushroom extract and geraniums improved immunity and fought the cancer and secondary infections that could have compromised treatment and health.[x] In a study of 18 patients diagnosed with low and intermediate myelodysplastic syndrome, which can lead to leukemia if not managed well, maitake mushroom extract treatment of three milligrams (mg) twice a day for 12 weeks increased immunity, positively affecting neutrophil, monocyte and free radical production.[xi] In a clinical study of asymptomatic children from 3 to 5 years old, treatment with beta glucans from reishi mushrooms showed increased immune system cells in the peripheral blood — signaling a strong defense against childhood infections.[xii] Reviewing in vivo and in vitro studies on mice and human cell lines using lion’s mane (Hericium erinaceus) and tiger tail (Trametes versicolor) mushrooms, treatments showed immunomodulatory, anticancer, anti-inflammatory and neuroregenerative effects.[xiii] 3. Antioxidant Polysaccharide beta glucan extracted from reishi mushroom was shown to be a powerful antioxidant in 37 high risk and 34 stable angina patients; those who were treated with 750 mg per day for three months had significantly decreased oxidative radicals and improved progression of atherosclerosis.[xiv] In a study of 42 healthy subjects, another intervention with beta glucan from reishi mushrooms of 225 mg per day for three months demonstrated its antioxidative effects — enhanced total antioxidant capacity and enzyme activities as well as reduced mild fatty liver condition to normal by suppressing oxidative stress were observed.[xv] 4. Anti-inflammatory  Crohn’s disease is a chronic inflammatory disease of the gastrointestinal tract. Treatment with a triterpene compound from reishi mushrooms showed that the inflammatory cytokines were significantly inhibited in a study of children with Crohn’s disease.[xvi] Sixty patients with moderate persistent asthma were studied and those who took the cordyceps sinensis mushroom capsule for two months had reduced airway inflammation caused by their chronic asthma.[xvii] Cordycepin from medicinal mushrooms showed strong effects on many anti-inflammatory diseases.[xviii] In a study of 32 patients with active rheumatoid arthritis, supplementation of medicinal mushroom and Chinese herbs — reishi (4 grams) and San Miao San (2.4 grams) daily — lowered arthritic pain for patients.[xix] The data in a mice study support a model where white button mushrooms regulate immunity in vitro and protect the colon from inflammation-induced injuries in vivo.[xx] The brain is susceptible to inflammation as well. In an Alzheimer’s disease model of rats, treatment with medicinal mushroom extracts delayed disease progression, improved learning and memory functions and stopped neural cell deaths and brain atrophy.[xxi] Chaga mushrooms administered to mice successfully protected against Alzheimer’s disease by modulating oxidative stress, Nrf2 signaling and mitochondrial cell deaths while improving memory and cognition.[xxii] Cordycepin from the Cordyceps sinensis mushroom alleviated Parkinson’s disease motor disorder symptoms by lowering oxidative stress and inflammation in vivo and in vitro.[xxiii] Lion’s mane mushrooms were supplemented for 12 weeks and were effective in preventing dementia and cognitive decline.[xxiv] Lion’s mane supplementation for four weeks in a study of 30 females also reduced depression and anxiety.[xxv] 5. Antidiabetic Dyslipidemia, high blood cholesterol and triglycerides is often a harbinger of future diabetes. In a rat model, white button mushrooms and a probiotic were found to lower dyslipidemia and decrease oxidative stress.[xxvi] In a study of 89 diabetic patients, oyster mushroom consumption significantly reduced blood glucose, blood pressure, triglycerides and cholesterol without ill effects on the liver or kidneys.[xxvii] Polyphenols from Phellinus igniarius, or willow bracket, mushroom extract were used in vitro and in vivo studies of induced Type 2 diabetes mice and showed improved glucose tolerance, reduced hyperglycemia and normalized insulin levels.[xxviii] Diabetic nephropathy, kidney disease caused by Type 2 diabetes, was studied in vitro with disease-induced rats and treatment with Cordyceps cicadae resulted in improved insulin resistance and glucose tolerance, suppressed inflammation and balanced gut microbiome thus stopping the diabetes-related progression of renal disease and tumors.[xxix] In an animal study, maitake mushroom prevented the progression of kidney fibrosis in diabetic nephropathy rats, significantly decreased fasting blood glucose levels, reduced inflammatory cytokines and lowered renal fibrosis indexes indicating its effectiveness in the treatment or prevention of nephropathy.[xxx] In their meta-analysis of 623 articles and 33 randomized controlled experiments using cauliflower mushroom extract (S. Crispa), researchers found statistically significant differences in diabetic symptoms including decreased serum insulin levels and wound rates and an increase in nutrient intake content.[xxxi] Mushrooms and Their Medicinal Powers Medicinal mushrooms are widely researched and used as treatment in the prevention and progression of many diseases from cancer and asthma to diabetes and dementia. Mushrooms protect you due to their anti-inflammatory, antitumor, antidiabetic, immune boosting and antioxidant activities. To learn more, see GreenMedInfo.com’s database on mushrooms.          

This week Jonathan Healy speaks to Sabrina Hill of Kopper Hair Salon, Paul Kavanagh of McCarthy Insurance Group and Neil Murphy of Con Murphy's Menswear about the reopening of business in Cork. Sabrina Hill talks about the realities of reopening - working at half capacity, shift work, gowns and visors. Paul Kavanagh of McCarthy Insurance Group says - “Our focus is getting businesses and the economy going again” Neil Murphy of Con Murphy’s Menswear tells Jonathan - “The store was established in 1932, it was the first time that the store closed for any period over three days.”

Retailers across the country have reopened their doors to customers today as we move into phase 2 of easing lockdown restrictions.  We heard from  Greg Kelly, Managing Director of Des Kelly Interiors,Neil Murphy, Owner of Con Murphy Menswear in Cork and  Gerard Keane, Keanes Jewelers, outlets in Limerick, Killarney and Cork. Listen and subscribe to Newstalk Breakfast on Apple Podcasts or Spotify.     Download, listen and subscribe on the Newstalk App.    You can also listen to Newstalk live on newstalk.com or on Alexa, by adding the Newstalk skill and asking: 'Alexa, play Newstalk'.

Today Marc has been joined by Neil Murphy from Bytes Technology Group. They discuss the impact of the COVID-19 crisis on Bytes' plans to float later in 2020 and how impressed Neil has been with the way his staff have adapted to remote working. They also talk about the way the channel has come together to really help end users over come their challenges.

Neil Murphy talks about his experience with the 2019 Death Race, and what keeps him coming back to all of these insane endurance events. Jason Barnes explains his road to Spartan, and what went into this year's Summer Death Race. He also lets us know about the Peak trail races in Vermont throughout the year. Todays Podcast is sponsored by: Ragnar Relay – Get out runragnar.com and get $80 any street or trail team relay using code ORM2019. Show Notes: Leave a review Death Race Peak Trail Races Team Regiment Support Us On Patreon Buy some obstacle racing merch!

King John II of France is missing from the pages of history. There are no movies, no books, hardly a Wikipedia page. But, after Jenks dug in to the mystery of this seemingly forgotten king, a whole medieval world came to life. As it turns out, John II, perhaps better known as John the Good, sailed to England to turn himself in as a prisoner of war, abandoning his stunned French subjects to fend for themselves through the Dark Ages. Is he the worst king in history? Or, has he been unfairly lost to the annals of time? What Really Happened? Guests: David Green (author/historian), Michael Jones (author/historian), Michael Pye (author/historian), Neil Murphy (author/historian), and Peter Hoskins (author/historian)

The Neil Patrick Patrick (yes, 2 names) Murphy comes onto the podcast to bring his unadulterated view in on the Star Wars series. (This was recorded January 18 of 2017 - forgive the audio.)Tell us what you think!FACEBOOK: https://www.facebook.com/thenetflixexplorersTWITTER: @TheNetExITUNES: https://itunes.apple.com/us/podcast/netflix-explorers-podcast/id1200124353?mt=2Leave a comment on Facebook and review us on iTunes!

Episode 133 - On today's show, we talk endurance training. The first guest is Miguel Medina. Matt recently signed up for Yancy Camp, and chose Coach Miguel to make him a better obstacle racer. (and to help prvent further DNFs!)  This is the first of what we plan on being several chats, leading up to World's Toughest Mudder in November. Next up is Neil Murphy with Regiment Running. Neil got some early dish on the 2015 Spartan UltraBeast. Matt called him to find out what he learned from UB course director Norm Koch. We also dig in to see what Neil and his Florida crew of banditos have been doing the last few years, as they have created some great endurance training. Today's show is sponsored Rugged Maniac.  ORM10 gets you $10 off all cities in 2015! Today's show is also sponsored by Udder Mud Run.  RUNORM gets you $10.00 of the 8/8/15 event! Show Notes Yancy Camp $29 a month for some badass training with the elite OCR athlete of your choice. Regiment Running Next T3 is July 25, plus weekly trainings, and The UltraBeast updates! 2015 Spartan UltraBeast Weekend Page Matt's 2014 ORM UltraBeast Review

Dermot Healy's writing+literary work with his editors Bill Swainson+Peter Fallon; poet Mary O'Malley; Keith Hopper who with Neil Murphy is editing his writing+related essays; Timothy O'Grady in whose film of his book 'I Could Read The Sky' Dermot featured; writer Brian Leyden who edited Force 10 and Neil Jordan, writer and longtime friend of Healy.

Former guest and friend of the show Neil Murphy returns to talk about his upcoming (long) short, Underside. Years in the making, Underside is finally ready to roll cameras and needs help. Donate to the Kickstarter here: https://www.kickstarter.com/projects/1241678072/underside

Training for your sport with special guest Neil Murphy, sports scientist and strength and conditioning trainer for the Golden Lions. Also, rugby vs. American football.

Neil Murphy takes his experience submitting and being accepted to film festivals and attempts to impart the lessons he’s learned.

Fellow filmmaker Neil Murphy discusses his early filmmaking life, the pitfalls of amateur short films, and his vast festival experience.

ESF President Neil Murphy speaks on the Green Economy in an interview by George Kilpatrick on WCNY's Central Issues program.

Students, professors, researchers and ESF president Neil Murphy provide an overview of the programs and opportunities that make ESF unique in the nation.