Podcasts about adeno

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Best podcasts about adeno

Latest podcast episodes about adeno

Oncology Brothers
HERIZON-GEA-01: FDA Approval of Zanidatamab + Tislelizumab for HER2+ Esophageai/GEJ/Gastric Adeno

Oncology Brothers

Play Episode Listen Later Aug 25, 2026 16:07


We had a chance to dive into one of the most significant advancements in the treatment of HER2-positive gastroesophageal junction (GEJ) and gastric adenocarcinoma. In this episode, we discussed the groundbreaking HERIZON-GEA-01 study that led to the approval of zanidatamab, a novel bispecific HER2-directed antibody.   We welcomed Dr. Nataliya Uboha, a GI medical oncologist from the University of Wisconsin, who shared her insights on the study's design, findings, and the implications for clinical practice. Learn about the importance of biomarker testing, the mechanism of action of zanidatamab, and how it compares to traditional therapies like trastuzumab.   Key topics covered in this episode: Overview of the HERIZON-GEA-01 study and its findings Mechanism of action of zanidatamab Comparison of treatment regimens and overall survival benefits Management of side effects, including diarrhea and infusion reactions The role of PD-L1 testing in treatment decisions   Whether you're a healthcare professional or simply interested in the latest in oncology, this episode provides valuable insights into the evolving landscape of treatment for HER2-positive upper GI malignancies.   Listen us on: Spotify: https://open.spotify.com/show/31BXhY9FM4gPWG10WgE11o Follow us on social media: ⁠X/Twitter: https://x.com/oncbrothers  ⁠Instagram: https://www.instagram.com/oncbrothers  Website: https://oncbrothers.com/    Don't forget to like, subscribe, and check out our other discussions on FDA approvals, treatment algorithms, and challenging cases!   #GastricCancer, #HER2positive, #Zanidatamab, #HERIZONGEA01, #OncologyBrothers  

Smart Biotech Scientist | Bioprocess CMC Development, Biologics Manufacturing & Scale-up for Busy Scientists
281: When Your Delivery Vehicle Contains a Membrane Protein: CMC Decisions With No Regulatory Precedent with Jitendra Kumar - Part 1

Smart Biotech Scientist | Bioprocess CMC Development, Biologics Manufacturing & Scale-up for Busy Scientists

Play Episode Listen Later Aug 25, 2026 20:13


Gene therapy only works if the cargo reaches the right cells intact. Adeno-associated viruses (AAV) and lipid nanoparticles have carried the field this far, but both share a constraint: the particle is taken up into an endosome, and the payload has to escape that compartment before it is degraded. Endosomal escape is where a large share of the dose is lost, and it is why delivery, not the genetic construct, is usually the thing that limits the therapy. Lipid nanoparticles carry a second constraint, since they tend to accumulate in the liver, which narrows the diseases they can reach. What if the particle never entered that way at all?Jitendra Kumar, Lead Scientist for Chemistry and Process Development at Entos Pharmaceuticals, works on a platform that fuses directly with the cell membrane and releases its cargo straight into the cytosol. He came to nanoparticle design the long way, through fifteen years of structural biology on the prion protein in Frankfurt and Edmonton, which is why he thinks about particle size, packaging and diffusion the way he does.Key topics discussed:Jitendra's career background in structural biology and journey to Entos Pharmaceuticals (03:18)The scientific motivation and challenges of working with prion proteins and breaking down complex diseases (04:55)Genetic medicine approaches: gain-of-function vs. loss-of-function, and the role of siRNA, ASOs, and gene delivery (06:27)The FAST protein platform: origins, function, and advantages for drug delivery (07:56)Manufacturing differences compared to LNPs, including the introduction of recombinant membrane protein production and related CMC complexity (09:55)Scale-up and production challenges for membrane proteins, and strategies for clinical supply (11:21)Clinical development progress: Phase 1/2 studies with the platform, especially for COVID vaccine delivery (12:23)Focus areas for the technology, including selective lung delivery and leptin therapy for lipodystrophy (13:12)Lessons for small biotech companies in phase 1/2 manufacturing strategy, technology transfer, and the value of an experienced network (14:31)Balancing process robustness with speed in new biotech ventures (16:02)The importance of identifying “pause steps” and must-have vs. nice-to-have features in early manufacturing processes (17:15)Smart insight: Jitendra's takeaway for startups: for early phases, find a partner who genuinely understands your tech and can move at your pace rather than defaulting to a big CDMO, treat your network as infrastructure, and build the ability to run production in-house. The one thing that's never up for negotiation is process robustness. The real question isn't robustness vs. speed, but how many checkpoints and safe pause points you build in so you can have both.If this conversation got you thinking about how novel delivery vehicles reach the cell — and what it takes to carry one from bench through CMC, scale-up, and regulatory review — these four episodes go deeper:Episodes 125 - 126: How to Enhance Cell Engineering Using Mechanical Intracellular Delivery with Armon ShareiEpisodes 231 - 232: From IND to BLA: The Biologics CMC Decisions That Determine Regulatory Success with Henri KornmannEpisodes 89 - 90: Scale-Up Secrets: Cracking the Code of AAV Production with Ahmed YoussefEpisodes 71 - 72: Effective Outsourcing: How Small Biotech Companies Can Thrive with Mark MelvilleConnect with Jitendra Kumar:LinkedIn: www.linkedin.com/in/jkumar2Email: jitendra.kumar@entospharma.comWebsite: www.entospharma.comFree 5-day email course, The CMC Failure Chain: the five recurring CMC mistakes that put your promising program at risk → Get it hereSupport the show

Rare Disease Discussions
Chapter 2: AAV Mediated Gene Therapies

Rare Disease Discussions

Play Episode Listen Later Dec 22, 2025 5:07


Alan Beggs, PhDDirector of the Manton Center for Orphan Disease ResearchSir Edwin and Lady Manton Professor of Pediatrics, Boston Children's HospitalHarvard Medical School, Boston, MA, USA Julie A. Parsons, MDHaberfield Endowed Chair in Pediatric Neuromuscular DisordersProfessor of Clinical Pediatrics and NeurologyUniversity of Colorado School of Medicine, Children's Hospital ColoradoAurora, CO, USADoctors Beggs and Parsons discuss the current status of gene therapies in rare neuromuscular disorders in this eight part podcast series. This is derived from the symposium that was presented at the MDA 2025 conference in Dallas, Texas, in March 2025 and is intended for healthcare professionals only. This podcast includes information about investigational compounds that do not yet have a regulatory approval or authorization for a specific indication. The safety and efficacy of the agents under investigation have not been established. In contents of this podcast, shall not be used in any manner to directly or indirectly promote or sell the product for unapproved uses. The ASPIRO clinical trial is on clinical hold since September 2021.In this part, Doctor Beggs will provide an explanation of AAV-mediated gene therapies.Alan Beggs, PhDAAV vectors, which I'm going to be talking about more today, or Adeno associated viral vectors are small viruses. Their DNA gets delivered into the cell and remains extrachromosomal. There are very rare occasional integrations, but the risk of oncogenesis as a result is significantly lower as a consequence of remaining extrachromosomal, though, we do have to think about what happens as the cells divide and potentially the durability of treatment is more limited.There have been a lot of movement and development over the years, starting back in the 1980s when the first AAV genomes were isolated and sequenced. This led to a development of methods to produce recombinant AAVs that would lack the genes necessary for viral replication, but contain a therapeutic gene you wish to deliver. Through this, the structure of AAVs have been developed. There have been isolation of a number of naturally occurring variants. You've heard of AAV8, AAV9, also RH 74, derived from a rhesus monkey for the RH. These have all been used in clinical trials. Then at the end I'll talk a little bit about directed evolution methods to actually engineer capsids with particular properties that are beneficial.Throughout this we've identified some of the issues that arise in this. It was initially thought that AAV vectors were non-immunogenic, but in fact there are immune responses not just to the viral payload to the therapeutic protein, but also to the viral vectors, and you're going to hear about that from Doctor Parsons. Over time, as we've come to understand these challenges, we've also been developing approaches to mitigate them. In terms of clinical trials and treatments, the very first studies were done back in the 1970s.By the early 2000, the very first clinical therapeutic was approved in China. It was actually an oncolytic virus carrying a p53 gene to treat head and neck cancers. By now there are over 40 approved treatments for various types of AAV delivered gene therapies. Of course, the ones we know a lot about are Zolgensma, which was approved in 2019, and Elevidys, which was approved last year. A number of challenges and then also a number of approaches to overcome those challenges. First of all, the preclinical data are not always sufficient to predict the response of a human patient.For example, in X-linked myotubular myopathy we had mouse and dog models that exhibited a myopathy but nothing else, and yet when we treated human patients, we discovered that patients with X-linked myotubular myopathy actually had a previously only poorly recognized hepatopathology that led to potential liver consequences following gene therapy. The animal models don't always predict the clinical outcome in humans.Also, we have small disease populations. These are rare diseases. It's important to understand the natural history of these diseases, understand the heterogeneity among the clinical population. It's very important to engage with families and with patients and communities, understand who might be at increased risk to treatment with one of these. This feeds into safety considerations. We need to think also about some of the immune responses. I think we're starting to learn, for example, with the gene therapies for Duchenne, and we know this from SMA that some patients get into trouble and others don't. We need to understand why that may be, and we don't know about the long term effects. This has been very recent.

MORTAL AND STRONG - The Podcast
Mortal and Strong - Voice No. 94 - Tanya

MORTAL AND STRONG - The Podcast

Play Episode Listen Later Aug 22, 2025 47:07


Welcome back to another episode of the Mortal and Strong podcast!Today, Dr Liz is joined by the powerhouse that is Tanya. Tanya talks us through her health journey which started at just 8 years old when she began experiencing severe migraines, these migraines continued for many years until in her early 20's, Tanya suffered a stroke. She was later diagnosed with Factor V Leiden, a blood clotting disorder, that had led to these migraines and eventual stroke. Tanya also shares her intense journey of living with Endometriosis and Adenomyosis, discussing how she overlooked heavy bleeding, and pain, as she was told these were simply 'normal' symptoms of menstruating. It wasn't until she was older, that these diagnosis' came, and Tanya became a fierce advocate for people with Endo and Adeno. Tanya discusses the many things she feels she has missed out on due to these conditions; that she feels she could be a better mum, how she lost her job, and talks of the general struggles and exhaustion you face when you are chronically ill. Today, Tanya holds workshops in schools, colleges, and workplaces to further educate people on all things menstrual health. Tanya speaks so openly about these conditions, and is dedicated on raising awareness and education so women don't have to suffer alone. We are so grateful to Tanya for becoming another one of our fantastic Voices for the Scars of Gold campaign.Scars of Gold is a health awareness campaign sharing the voices of 100 women facing their mortality at a young age with life changing or incurable health conditions. Produced by charity @mortalandstrong (No.1209448).#podcast #podcastprevious #interview #mortalandstrong #scarsofgold #kintsugi #adenomyosis #endometriosis #endo #adeno #menstrualhealth #gynaehealth Hosted on Acast. See acast.com/privacy for more information.

The Well
The Strangest Place You Can Find Endo

The Well

Play Episode Listen Later Apr 2, 2025 25:03 Transcription Available


Where's the strangest place you can find endo? Can you make more money when you're ovulating? And is it heartburn or a heart attack? In this episode we talk to gynaecological surgeon and endometriosis specialist, Dr Amani Harris and learn the telltale signs of a female heart attack. Sign up to the Well Newsletter to receive your weekly dose of trusted health expertise without the medical jargon. Ask a question of our experts or share your story, feedback, or dilemma - you can send it anonymously here, email here or leave us a voice note here. THE END BITS Follow us on Instagram and Tiktok. All your health information is in the Well Hub. For more information on endometriosis, visit Endometriosis Australia. For more information on periods and a pain and symptom diary, Dr Mariam recommends the Jean Hailes website. For more on heart attack signs and symptoms in women, visit the Heart Foundation. Support independent women’s media by becoming a Mamamia subscriberCREDITSGuest: Dr Amani HarrisHosts: Claire Murphy and Dr MariamSenior Producers: Claire Murphy and Sasha TannockAudio Producers: Scott StronachVideo Producer: Julian Rosario Mamamia acknowledges the Traditional Owners of the Land we have recorded this podcast on, the Gadigal people of the Eora Nation. We pay our respects to their Elders past and present, and extend that respect to all Aboriginal and Torres Strait Islander cultures. Information discussed in Well is for education purposes only and is not intended to provide professional medical advice. Listeners should seek their own medical advice, specific to their circumstances, from their treating doctor or health care professional.Support the show: https://www.mamamia.com.au/mplus/See omnystudio.com/listener for privacy information.

The Genetics Podcast
EP 155: Adeno-associated virus as a delivery vector for genetic eye disease treatment, with Paul Wille of Abeona Therapeutics

The Genetics Podcast

Play Episode Listen Later Oct 10, 2024 32:18


This week Patrick is joined by Paul Wille, Director of Product Development at Abeona Therapeutics. They discuss the use of adeno-associated virus (AAV) as a vector for gene therapy delivery, outline its limitations and benefits, and hone in its potential in the context of genetic eye disorders. Paul also shares his journey from academia to industry and emphasizes the importance of building on existing technologies to advance the field. Additionally, please consider joining us at our first in-person podcast event! We will be hosting a reception during the ASHG Annual Meeting in Denver, CO. The event will be held on the evening of Thursday 7 November. ​Please submit your information in this form (https://lu.ma/geneticspodASHG) to signify your interest in attending!

Region - Praha a Střední Čechy
Středočeské příběhy: Přadeno lnu i obrázky pražských zákoutí Ivana Svatoše ukazuje Malá letní galerie na Třech Studních

Region - Praha a Střední Čechy

Play Episode Listen Later Aug 28, 2024 3:06


Na jednom z nejmenších náměstí u nás - uprostřed obce Tři Studně na Žďársku - je už třicet let každé léto otevřena Malá galerie. Založila ji rodina malíře a grafika Ivana Svatoše, který v ní nabízí své obrázky pražských zákoutí a ulic, ale také Vysočiny i jiných míst.

Endometriosis En Lo Profundo
22. Lupron: Decisión informada. Con Andrea Ruiz Presidenta de la Asociación de Pacientes con Endo y Adeno del Perú

Endometriosis En Lo Profundo

Play Episode Listen Later Jun 30, 2024 70:34


Hoy hablo con Andrea Ruiz. Conversamos sobre:-Lupron, que es parte de una categoría de medicamentos llamados GnRh que baja tu estrógeno a niveles menopáusicos. -como varios estudios que comparan los medicamentos GnRh con otros medicamentos hormonales muestran que todos ellos proporcionan un alivio similar de los síntomas.-como el Lupron pueden tener efectos secundarios graves, e incluso incapacitantes, a largo plazo que continúan en algunos pacientes mucho después de dejar de tomar el medicamento.Quién es Andrea Ruiz?Andrea es Presidenta de la Asociación de Pacientes con Endometriosis y Adenomiosis del Perú. Hablamos en el episodio 3 sobre la nueva ley de endometriosis en Perú y su importancia para la comunidad de endometriosis en Perú.Para contactar con Andrea:INSTAGRAM @endometriosisperuFACEBOOK: Pacientes Endometriosis Perú. https://www.facebook.com/endometriosisperu¿Quieres más información en español sobre la endometriosis?LUPRON: https://insixteenyears.com/lupron-2/MI PÁGINA WEB: www.endoenloprofundo.comINSTAGRAM: @endo.en.lo.profundo

DEARG: Delivering Endometriosis and Adenomyosis Resources and Guidance
Jen Moore. They Said What?! Exposing Medical Gaslighting & Taking Charge of Endo/Adeno

DEARG: Delivering Endometriosis and Adenomyosis Resources and Guidance

Play Episode Listen Later May 15, 2024 54:21


Summary Jen Moore, aka Jen.dometriosis on social media, is an endometriosis and adenomyosis educator, speaker and campaigner. Following her 22 year long battle for a diagnosis, she now helps others suffering with these conditions, as well as working to create change on an institutional level.She has worked with the BBC, NHS, University of Cambridge, and global pharmaceutical companies; as well as contributing to research, books and consulting for national charities. Jen is a UN Women UK delegate for the 68th Commission on the Status of Women, where she is determined to include endometriosis and adenomyosis in these vital and high level discussions.Jen is also the founder of two Endometriosis based research projects. The first, Endo Education, is looking at the current state of medical teaching in the UK when it comes to endometriosis. The second, the They Said What?! project is a deeply personal piece of work, collating the lived experiences of medical misogyny faced by those suffering with the disease. In this episode, Kathleen chats with Jen, about her journey with endometriosis and adenomyosis. They discuss the importance of accurate information and definitions, the impact of misinformation and lack of education, the role of healthcare professionals in education, the hope for change and future generations, and the importance of sharing personal stories and accurate information on social media. Jen shares her experience of upskilling and educating herself on endometriosis and adenomyosis and provides advice for others who want to do the same. This conversation covers topics such as misinformation and media influence, the power of social media, the "They Said What" project, the impact of medical gaslighting, raising awareness for adenomyosis, and the emotional journey of a hysterectomy. It also discusses the complexities of post-surgery pain. Takeaways Be cautious of misinformation and sensationalised headlines in the media and on social media. Stay curious, ask questions, and think critically about the information you come across. The They Said What project aims to document and amplify experiences of medical gaslighting and dismissal in women's healthcare. It highlights the need for change and exposes the widespread issue of medical mistreatment. Adenomyosis is a condition that is often overlooked and misunderstood. More awareness and research are needed to address the impact of adenomyosis on individuals' lives. The emotional journey of a hysterectomy can be complex, and individuals may experience conflicting emotions. It is important to provide psychological support and acknowledge the significance of the choice to undergo a hysterectomy. Post-surgery pain can persist even after a hysterectomy and excision, and additional work may be required to address other pelvic pain generators. It is essential to have realistic expectations and explore all available tools for pain management. Jen's Website https://www.jenmoore.co.uk/ Jen on Instagram https://www.instagram.com/jen.dometriosis/ They Said What Submissions https://www.jenmoore.co.uk/projects/theysaidwhatproject They Said What?! Instagram https://www.instagram.com/theysaidwhatproject/

The Female Health Solution Podcast
611. How To Know If You Have Adenomyosis

The Female Health Solution Podcast

Play Episode Listen Later Mar 28, 2024 14:15


If you've heard of endometriosis, you may know of a similar condition: adenomyosis. Adenomyosis is the growth of endometrial-like tissue growing into the muscle of your uterus. Adeno can create symptoms that are even more severe and difficult to resolve like pelvic pain and pain with your period. In this episode, I dive into the signs of adenomyosis and how to determine if you are struggling with it.  DUTCH Test: https://drbethwestie.com/dutch-hormone-testing/

The Female Health Solution Podcast
574. The Root Cause of Adenomyosis

The Female Health Solution Podcast

Play Episode Listen Later Nov 16, 2023 11:39


If you've heard of endometriosis, you may know of a similar condition: adenomyosis. Adenomyosis is the growth of endometrial-like tissue growing into the muscle of your uterus. Adeno can create symptoms that are even more severe and difficult to resolve like pelvic pain and pain with your period. In this episode, I dive into the root cause of adenomyosis and some treatment options.  DUTCH Test: https://drbethwestie.com/dutch-hormone-testing/

Proof of Coverage
Episode 10 - Maria Lema, Co-Founder of Weaver Labs

Proof of Coverage

Play Episode Listen Later Oct 6, 2023 30:34


In this episode of the Proof of Coverage podcast, Sal interviews Maria Lima, the founder of Weaver Labs and the Adeno network. Maria shares the origin story of Weaver Labs and discusses their work in powering lab deployments across Europe. They delve into the innovative technology behind Weaver Labs, including their full-stack modular software platform for scaling wireless networks. Listeners will gain insights into the exciting advancements being made in the field of telecommunications. Follow Maria:  ⁠@MariaMariuru [00:02:05] Demo or die approach. [00:04:41] Decentralizing telecommunications infrastructure. [00:08:30] Innovation in the telecom ecosystem. [00:09:41] UK's investment in telecoms. [00:14:50] Building a 5G private network. [00:16:20] Using street furniture for network deployment. [00:19:58] Neutron host model explained. [00:23:34] Fixed wireless access trial. [00:26:14] Residential connectivity cost analysis. [00:30:16] Telecom sector funding scarcity. Disclaimer: The hosts and the firms they represent may hold stakes in the companies mentioned in this podcast. None of this is financial advice.

The Female Health Solution Podcast
538. Top 5 Symptoms of Adenomyosis

The Female Health Solution Podcast

Play Episode Listen Later Jul 13, 2023 12:30


You may be familiar with endometriosis, but this episode is dedicated to a similar condition: adenomyosis. Adenomyosis is the growth of endometrial-like tissue growing into the muscle of your uterus. Adeno can create symptoms that are even more severe and difficult to resolve like pelvic pain and pain with your period. In this episode, I dive into the top 5 symptoms of Adeno and what you can do about it!  DUTCH Test: https://drbethwestie.com/dutch-hormone-testing/

PaperPlayer biorxiv cell biology
Differential regulation of hair cell actin cytoskeleton mediated by SRF and MRTFB

PaperPlayer biorxiv cell biology

Play Episode Listen Later Jun 26, 2023


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.26.546585v1?rss=1 Authors: Wu, H., Zhou, L.-Y., Jin, C.-X., Wang, W.-X., Song, L., Shin, J.-B., Du, T.-T. Abstract: The MRTF-SRF pathway has been extensively studied for its crucial role in driving the expression of a large number of genes involved in actin cytoskeleton of various cell types. However, the specific contribution of MRTF-SRF in hair cells remains unknown. In this study, we showed that hair cell-specific deletion of Srf or Mrtfb, but not Mrtfa, leads to similar defects in the development of stereocilia dimensions and the maintenance of cuticular plate integrity. We used FACS-based hair cell RNA-seq analysis to investigate the mechanistic underpinnings of the changes observed in Srf and Mrtfb mutants, respectively. Interestingly, the transcriptome analysis revealed distinct profiles of genes regulated by Srf and Mrtfb, suggesting different transcriptional regulation mechanisms of actin cytoskeleton activities mediated by Srf and Mrtfb. Exogenous delivery of calponin 2 using Adeno-associated virus transduction in Srf mutants partially rescued the impairments of stereocilia dimensions and the F-actin intensity of cuticular plate, suggesting the involvement of Cnn2, as an Srf downstream target, in regulating the hair bundle morphology and cuticular plate actin cytoskeleton organization. Our study uncovers, for the first time, the unexpected differential transcriptional regulation of actin cytoskeleton mediated by Srf and Mrtfb in hair cells, and also demonstrates the critical role of SRF-CNN2 in modulating actin dynamics of the stereocilia and cuticular plate, providing new insights into the molecular mechanism underlying hair cell development and maintenance. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Aus Forschung wird Gesundheit
Kann eine Gentherapie bei Epilepsie helfen?

Aus Forschung wird Gesundheit

Play Episode Listen Later Jun 14, 2023 23:46


Wissenschaftler*innen von der Charité und der Medizinischen Universität Innsbruck haben nun die EpiBlok Therapeutics GmbH gegründet, die eine Gentherapie entwickelt, bei der ein Adeno-assoziiertes-Virus das Gen für das Neuropeptid Dynorphin gezielt in Neurone der betroffenen Hirnregion bringt. Ziel ist eine langfristige Unterdrückung von Anfällen, indem die Nervenzellen Dynorphin auf Vorrat produzieren und bei Bedarf ausschütten. Im Interview erklärt Prof. Regine Heilbronn, wie die Gentherapie funktioniert.

PaperPlayer biorxiv neuroscience
Cell specificity of adeno-associated virus (AAV) serotypes in human cortical organoids

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Apr 13, 2023


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.13.536491v1?rss=1 Authors: Stanton, M. M., Hariani, H. N., Sorokin, J., Taylor, P. M., Modan, S., Rash, B. G., Rao, S. B., Enriquez, L., Quang, D., Hsu, P.-K., Paek, J., Owango, D., Castrillo, C., Nicola, J., Ramkumar, P., Lash, A., Flanzer, D., Shah, K., Kato, S., Skibinski, G. Abstract: Human-derived cortical organoids (hCOs) recapitulate cell diversity and 3D structure found in the human brain and offer a promising model for discovery of new gene therapies targeting neurological disorders. Adeno-associated viruses (AAVs) are the most promising vehicles for non-invasive gene delivery to the central nervous system (CNS), but reliable and reproducible in vitro models to assess their clinical potential are lacking. hCOs can take on these issues as they are a physiologically relevant model to assess AAV transduction efficiency, cellular tropism, and biodistribution within the tissue parenchyma, all of which could significantly modulate therapeutic efficacy. Here, we examine a variety of naturally occurring AAV serotypes and measure their ability to transduce neurons and glia in hCOs from multiple donors. We demonstrate cell tropism driven by AAV serotype and hCO donor and quantify fractions of neurons and astrocytes transduced with GFP as well as overall hCO health. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Not Cha Momma Pod
April is Adenomyosis Awareness Month

Not Cha Momma Pod

Play Episode Listen Later Mar 30, 2023 37:26


April is Adenomysosis Awareness Month and the NCMP wanted to take time to discuss the disease in further detail. Betsy also reflects on her Adeno diagnosis and hysterectomy. Thank you for tuning in. Please let us know if you have any questions! Follow up on IG @notchamommapod. Make sure to like, share, and leave us a comment!

PaperPlayer biorxiv neuroscience
A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences.

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Feb 22, 2023


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.21.529451v1?rss=1 Authors: Gleichman, A. J., Kawaguchi, R., Sofroniew, M. V., Carmichael, S. T. Abstract: Astrocytes, one of the most prevalent cell types in the central nervous system (CNS), are critically involved in neural function in both health and disease. Genetically manipulating astrocytes is an essential tool in understanding and affecting their roles. Adeno-associated viruses (AAVs) enable rapid genetic manipulation; however, astrocyte specificity of AAVs can be limited, with high off-target expression in neurons and sparsely in endothelial cells. Here, we report the development of a cassette of miRNA targeting sequences (4x6T) which triggers transgene degradation specifically in neurons and endothelial cells. 4x6T increases astrocytic expression of Cre with a viral reporter from less than 50% to greater than 99% in four tested serotypes in mice, and confers astrocyte specificity in two inducible forms of Cre; Dre; and reporters. We also present empty vectors to add 4x6T to other cargo, independently and in Cre/Dre-dependent forms. This toolbox of AAVs provides a way to rapidly manipulate astrocytes throughout the CNS. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Empowered Hormones with Sheradyn Dekker
#99 Endo surgery, twins twice, marathons, bloating & mental health with Megan Peters

Empowered Hormones with Sheradyn Dekker

Play Episode Listen Later Dec 27, 2022 42:11


This episode is unlike anything I have done before... going deep & personal with my best friend and cousin on her wild, brave & incredible journey. We come from similar genetics (mothers are sisters), and we share some of the same health issues BUT Megan also has a totally different story to me when it comes to Endo, Adeno, childbirth, pregnancy, stress, training and mental health. I would love to hear your thoughts on this episode, as I am certain you are going to relate to so many of the things we chat about! If you relate to Megan's story please reach out, as you shouldn't have to walk this journey alone! Big love to you if your struggling and big love to Megan for being brave, being a mother, and for always striving to find an answer when life continues to throw her curve balls.  We cover: Training and your health Endometriosis & Adenomyosis Heavy, painful periods Mental health Two sets of twins Depleted bodies Immune dysfunction Trauma Bloating & gut issues Food intolerances And more! LINKS TO SHERADYN: Assess your gut health in 3min HERE Follow me on Instagram HERE.  Join my Private Facebook group HERE. Check out my website HERE See omnystudio.com/listener for privacy information.

Sự việc & Góc nhìn
Phòng khám nhi liên tục quá tải, nguy cơ dịch chồng dịch hiện hữu

Sự việc & Góc nhìn

Play Episode Listen Later Oct 29, 2022 10:50


Đậu mùa khỉ, Covid-19, Adeno và mới nhất là Cúm gia cầm xuất hiện… đã và đang uy hiếp sức khỏe cộng đồng, đặc biệt là các bệnh nhi.

VOV - Sự kiện và Bàn luận
360 độ sức khỏe: Phòng ngừa và điều trị Andenovirus

VOV - Sự kiện và Bàn luận

Play Episode Listen Later Oct 2, 2022 23:26


- Thưa quý vị và các bạn! Trước tình hình số lượng ca mắc virus Adeno phải nhập viện tăng cao, ngành y tế yêu cầu các cơ sở khám chữa bệnh bố trí đủ giường bệnh, nhân lực, phương tiện, trang thiết bị, vật tư để chẩn đoán và điều trị người bệnh nhiễm Adenovirus. Đồng thời thực hiện tốt công tác phân luồng, kiểm soát nhiễm khuẩn, phòng chống lây nhiễm trong các cơ sở khám chữa bệnh. Vậy Andeno virus cần nhận biết, điều trị, phòng ngừa ra sao? Xin mời quý vị và các bạn cùng nghe --- Support this podcast: https://anchor.fm/vov1sukien/support

VOV - Chương trình thời sự
Thời sự 12h (24/9/2022)

VOV - Chương trình thời sự

Play Episode Listen Later Sep 24, 2022 57:40


- Tiếp tục các hoạt động của Đoàn Việt Nam tham dự Phiên thảo luận cấp cao Đại hội đồng Liên hợp quốc Khoá 77 tại New York, Hoa Kỳ, Phó Thủ tướng Thường trực Phạm Bình Minh tham dự Hội nghị về Tác động của phát triển bền vững năm 2022 do Diễn đàn Kinh tế thế giới tổ chức - Ủy ban TVQH cho ý kiến về dự thảo Kế hoạch giám sát chi tiết và đề cương các báo cáo của Đoàn giám sát của Ủy ban Thường vụ Quốc hội về “Việc thực hiện chính sách, pháp luật về phát triển năng lượng giai đoạn 2016 – 2021 - Bộ Y tế họp khẩn tìm cách ứng phó dịch do virus Adeno khiến hàng nghìn trẻ nhập viện - Bão Noru sẽ vào biển Đông từ đêm mai, với sức gió cấp 9-10. Ban chỉ đạo quốc gia về Phòng, chống thiên tai yêu cầu các tỉnh từ Quảng Ninh đến Bình Thuận khẩn trương kêu gọi và hướng dẫn tàu thuyền nhanh chóng thoát ra khỏi vùng nguy hiểm - Hội nghị Bộ trưởng Công nghiệp, Thương mại và Đầu tư G20 kết thúc sau 3 ngày họp tại Bali, Indonesia, nhất trí về 6 chương trình nghị sự ưu tiên để giải quyết các thách thức thương mại, thúc đẩy sự phục hồi kinh tế toàn cầu hậu đại dịch - Chứng khoán toàn cầu lao dốc sau quyết định tăng lãi suất của các ngân hàng trung ương Chủ đề : bộ y tế, họp khẩn, trẻ nhập viện --- Support this podcast: https://anchor.fm/vov1thoisu0/support

VOV - Chương trình thời sự
Thời sự 6h (22/9/2022)

VOV - Chương trình thời sự

Play Episode Listen Later Sep 22, 2022 35:56


- Sáng 22/9, UB TVQH cho ý kiến vào Dự án Luật đất đai (sửa đổi). Đây là dự án Luật lớn, có tác động sâu sắc tới nhiều mặt của đời sống KT-XH của đất nước. - Hơn 300 trẻ nhập viện do virus Adeno, Bộ Y tế yêu cầu tăng cường giám sát, không để bùng dịch. - Khai mạc Lễ hội truyền thống tưởng niệm 154 năm Anh hùng dân tộc Nguyễn Trung Trực hy sinh. - Tổng thống Mỹ Joe Biden chỉ trích Nga trong cuộc khủng hoảng Ucraina. - Dư luận Nga ủng hộ việc Tổng thống Vladimir Putin ký sắc lệnh về động viên một phần quân đội - Cục Dự trữ Liên bang Mỹ (FED) công bố thêm một đợt tăng lãi suất mạnh nhằm hạ nhiệt lạm phát. -Bình luận:“Cán bộ giữ gìn liêm sỉ để cuộc đấu tranh phòng chống tham nhũng thành công”. Chủ đề : 300 trẻ nhập viện, virus Adeno, bùng dịch --- Support this podcast: https://anchor.fm/vov1thoisu0/support

VOA Talk Shows - VOA
Báo động nhập viện và tử vong tăng vì virus Adeno - Tháng Chín 22, 2022

VOA Talk Shows - VOA

Play Episode Listen Later Sep 21, 2022 53:36


Việt Nam báo động số ca nhập viện và tử vong tăng, đặc biệt nơi trẻ em, vì virus adeno. Virus adeno là gì, gây bệnh gì? làm sao tránh, có cách điều trị không? Cùng tìm hiểu với BS Nhi khoa Quỳnh Kiều.

VOV - Chương trình thời sự
Thời sự 18h (17/9/2022)

VOV - Chương trình thời sự

Play Episode Listen Later Sep 17, 2022 55:55


- Thủ tướng Chính phủ Chủ trì Hội nghị với doanh nghiệp, hiệp hội doanh nghiệp đầu tư nước ngoài. - Chủ tịch Quốc hội Vương Đình Huệ kiểm tra công tác chuẩn bị tổ chức Diễn đàn Kinh tế - Xã hội Việt Nam 2022. - Gần 1 nghìn tỷ đồng vốn đầu tư công tạm ứng bị biến thành “nợ khó đòi” – câu chuyện xảy ra tại tỉnh Đắc Lắc. - Lô sầu riêng đầu tiên của Việt Nam hôm nay lên đường chính thức xuất khẩu chính ngạch sang Trung Quốc. - Tổng thống Nga Putin kêu gọi châu Âu dỡ bỏ các lệnh trừng phạt để mở đường ống dòng chảy khí đốt phương Bắc 2. - Sập mỏ vàng vùi lấp 20 người sau sự cố sạt lở đất tại Indonesia. Chủ đề : Nga, Khí đốt, virus Adeno, sầu riên --- Support this podcast: https://anchor.fm/vov1thoisu0/support

Not Cha Momma Pod
Meet Nicki

Not Cha Momma Pod

Play Episode Listen Later May 26, 2022 65:48


Nick is a fellow Endo and Adeno warrior. She has survived infertility and is now embracing life post a hysterectomy. Most importantly, she a part of the Infertile Myrtles and has became a close friend to the pod. Follow her on IG @ourstoryunfolding. Like, share, and follow us on IG @notchamommapod and tag us in the movement challenge with the hashtag #movementmedicine. DM any gentle corrections or email us at notchamommapod@gmail.com. Anchor listeners - leave us voice messages at https://anchor.fm/notchamommapod/message.

I Like Girls
The Adeno Story

I Like Girls

Play Episode Listen Later May 24, 2022 30:45


In this episode, Nigerian actor, Nse Ikpe-Etim talks about being diagnosed with adenomyosis, a medical condition that affects the fertility of women. She discusses her journey to healing, and getting a hysterectomy. To get inside information about every episode, subscribe to our newsletter here. You will get behind-the-scenes information from Aisha Salaudeen, and find out what the rest of the team is up to. “I Like Girls” is Aisha Salaudeen, Afolabi Adekaiyaoja, Samiat Alamutu, Dorcas Ohwofasa, Dooski, Mo Isu, Ruth Olurounbi and Banggz. This episode is sponsored by Piggyvest.

The Hook Up
We need to talk about adenomyosis

The Hook Up

Play Episode Listen Later Apr 19, 2022 19:36


You've probably heard of endometriosis, but adeno is what we're calling endo's lesser known evil cousin. It's a hell of a chronic illness, and for Adenomyosis Awareness Month we're bringing you up to speed on what it is, why it often gets confused with endo, and how to cure it.For questions or topic suggestions email thehookup@abc.net.au or dm us @triplejthehookuphttps://www.instagram.com/triplejthehookup

The Hook Up
We need to talk about adenomyosis

The Hook Up

Play Episode Listen Later Apr 19, 2022 19:36


You've probably heard of endometriosis, but adeno is what we're calling endo's lesser known evil cousin. It's a hell of a chronic illness, and for Adenomyosis Awareness Month we're bringing you up to speed on what it is, why it often gets confused with endo, and how to cure it. For questions or topic suggestions email thehookup@abc.net.au or dm us @triplejthehookup https://www.instagram.com/triplejthehookup

The Hook Up
We need to talk about adenomyosis

The Hook Up

Play Episode Listen Later Apr 19, 2022 19:36


You've probably heard of endometriosis, but adeno is what we're calling endo's lesser known evil cousin. It's a hell of a chronic illness, and for Adenomyosis Awareness Month we're bringing you up to speed on what it is, why it often gets confused with endo, and how to cure it.For questions or topic suggestions email thehookup@abc.net.au or dm us @triplejthehookuphttps://www.instagram.com/triplejthehookup

The Hook Up
We need to talk about adenomyosis

The Hook Up

Play Episode Listen Later Apr 19, 2022 19:36


You've probably heard of endometriosis, but adeno is what we're calling endo's lesser known evil cousin. It's a hell of a chronic illness, and for Adenomyosis Awareness Month we're bringing you up to speed on what it is, why it often gets confused with endo, and how to cure it. For questions or topic suggestions email thehookup@abc.net.au or dm us @triplejthehookup https://www.instagram.com/triplejthehookup

Studio Chat
Guest: Sam Murray | Be your own health advocate

Studio Chat

Play Episode Listen Later Apr 13, 2022 69:44


In this episode I chat with Sam Murray from Empowered Holistic Counselling  & Wellness. A great episode for those men in your life too, to understand a bit more about Endo and how is not just about your period or 'that time of the month'.We had a great in-depth chat about being your own health advocate, learning about your intuition, using your voice and if something doesn't feel right to keep going until you find the answers that are right for you and sit right with you.  Sam has been living with Endo and Adeno and how it impacts her entire life. She speaks about her journey from 10yo and how she navigated and has dealt with things as they have come up, and the changes she has made to her life, career and health.What does a holistic health approach look like when 'pushing through' doesn't work.....Tune in to find out more! If you would like to connect with Sam, head over on Instagram @empowered_holistic_counselling + @empowered_skincare_rangeSupport the show (https://paypal.me/studiochatpodcast?country.x=AU&locale.x=en_AU)

Let's Talk, Period.
Let's Talk Adenomyosis Part 2

Let's Talk, Period.

Play Episode Listen Later Apr 10, 2022 15:27


Hey LTP fam! Welcome back for a brand spanking new ep of LTP!Today's solo episode is part 2 of all about adenomyosis! With it being adeno awareness month currently, I would it would be a great opportunity to share all about adeno and answer some questions from the LTP fam!  Things I mentioned in the ep:Is it Endo, Adeno or PCOS blog - Let's Talk, Period.1:1 Mentoring with Isabella Harada, T. et al. (2016). The Impact of Adenomyosis on Women's Fertility. Obstetrical and Gynaecological Survey, 71(9), 557-568. If you haven't got your ticket for our online textured paint and sip yet, get on it! Tickets are $65 and it is going to be SUCH a fun evening!! Get your ticket here If you want to keep updated with all things Let's Talk, Period. you can follow us on Instagram at @letstalkperiodau. Don't forget we also have our Let's Talk, Period. Community on facebook. It's the place for people with endo, adeno, pcos or chronic illnesses to ask questions, get support and connect with others who get it! You can join here!Let's Talk, Period. is an independent podcast, so if you did enjoy this episode and want to support the show,  it would be amazing if you could  follow on apple podcasts and leave a rating and review, or if you're listening along on spotify, you can follow the show  and leave a rating!If you want to help grow the Let's Talk, Period. community, you could share this episode with a friend or anyone who you think might enjoy our show or even share that you're listening on your instagram grid or stories! This really helps to find new listeners and build the beautiful LTP podcast community!Your host  is Isabella Gosling (@i_gosling)

Let's Talk, Period.
Let's Talk Adenomyosis

Let's Talk, Period.

Play Episode Listen Later Apr 3, 2022 22:32


Hey LTP fam! Welcome back for a brand spanking new ep of LTP!Today's solo episode is all about adenomyosis! With it being adeno awareness month currently, I would it would be a great opportunity to share all about adeno and answer some questions from the LTP fam!  Things I mentioned in the ep:Is it Endo, Adeno or PCOS blog - Let's Talk, Period.Frendo AppIf you haven't got your ticket for our online textured paint and sip yet, get on it! Tickets are $65 and it is going to be SUCH a fun evening!! Get your ticket here If you want to keep updated with all things Let's Talk, Period. you can follow us on Instagram at @letstalkperiodau. Don't forget we also have our Let's Talk, Period. Community on facebook. It's the place for people with endo, adeno, pcos or chronic illnesses to ask questions, get support and connect with others who get it! You can join here!Let's Talk, Period. is an independent podcast, so if you did enjoy this episode and want to support the show,  it would be amazing if you could  follow on apple podcasts and leave a rating and review, or if you're listening along on spotify, you can follow the show  and leave a rating!If you want to help grow the Let's Talk, Period. community, you could share this episode with a friend or anyone who you think might enjoy our show or even share that you're listening on your instagram grid or stories! This really helps to find new listeners and build the beautiful LTP podcast community!Your host  is Isabella Gosling (@i_gosling)

Let's Talk, Period.
Let's Talk with Aroha Liebhart | Endo, Adeno + PCOS Advocate

Let's Talk, Period.

Play Episode Listen Later Mar 24, 2022 47:13


It's time for another little bonus ep for endo awareness month! Today's bonus episode is with Aroha Liebhart. Aroha is an endo, adeno and PCOS sufferer and has had quite the tumultuous journey to diagnosis. She is passionate about making a difference in the lives of others, and has actively committed to advocate for others. Later this year will be embarking on a three day trek in WA to raise money for endometriosis research.  We chat on: Aroha's endo story and how she finally got diagnosed with endo, adeno and PCOSWhy she feels there is still such a delay to diagnosis, even in 2022Challenges and considerations Aroha has had to make to accommodate her illnessesWhat her chronic illnesses have given her All about the trek she is doing later in the year to raise money for endo researchPlus so much more! Thank you so much for listening to this episode of Let's Talk, Period. with Aroha.  If you want more from her, you can follow her on instagram @ladyb_16 and you can find out more about her upcoming trek, as well as donate here . If you want to keep updated with all things Let's Talk, Period. you can follow us on Instagram at @letstalkperiodau. Don't forget we also have our Let's Talk, Period. Community on facebook. It's the place for people with endo, adeno, pcos or chronic illnesses to ask questions, get support and connect with others who get it! You can join here!Let's Talk, Period. is an independent podcast, so if you did enjoy this episode and want to support the show,  it would be amazing if you could  follow on apple podcasts and leave a rating and review, or if you're listening along on spotify, you can follow the show  and leave a rating!If you want to help grow the Let's Talk, Period. community, you could share this episode with a friend or anyone who you think might enjoy our show or even share that you're listening on your instagram grid or stories! This really helps to find new listeners and build the beautiful LTP podcast community!Your host  is Isabella Gosling (@i_gosling)

Hypermobility Happy Hour
40 - Exciting Research on EDS in Animals: Dr. Heather Gray-Edwards and Dr. Abby McElroy

Hypermobility Happy Hour

Play Episode Listen Later Mar 23, 2022 36:18


On this episode, we have returning guest Dr. Abby McElroy who previously was a guest on the Hypermobility Happy Hour discussing EDS in animals. Today, she returns with her principal investigator Dr. Heather Gray-Edwards to discuss the exciting new research they have been working on. Dr. Gray-Edwards is an assistant professor of Radiology at the University of Massachusetts' Chan Medical School and is a member of the Horae Gene Therapy Center. Much of her research has been focused on evaluating therapeutic interventions in testing novel Adeno-associated viral vectors and delivery routes using both biochemical and molecular biology techniques, as well as in vitro evaluation like neurological examinations, MRIs, and electrodiagnostics of GM1 and GM2 gangliosidosis cats. Dr. McElroy is a doctoral student who previously received her Doctor of Veterinary Medicine degree from Tufts University in 2017. She further obtained a master's degree from Michigan State University in 2018 which focused on the characterization of neurological abnormalities in an equine model of Ehlers-Danlos syndrome. From 2018 to 2021, Dr. McElroy was a Postdoctoral Research Associate in the Department of Neurosurgery at Rhode Island Hospital and the Medical School of Brown University where she studied tethered cord syndrome and myodural bridge dysfunction in patients with Ehlers-Danlos Syndrome. In her current position at the Gray-Edwards laboratory at the University of Massachusetts' Chan Medical School focuses on the development of gene therapy for Ehlers-Danlos syndromes and multisystemic smooth muscle dysfunction syndrome (related to the ACTA2 mutation). Abby also has two cats and two dogs and one of her cats has Ehlers-Danlos syndrome and is a bit of a social media star in his own right (his name is Reed and you can follow him at reed_eds)

SAGE Veterinary Science
TPX 2022 Series - EP1: Scientific and Regulatory Policy Committee Points to Consider: Nonclinical Research and Development of In Vivo Gene Therapy Products, Emphasizing Adeno-Associated Virus Vector

SAGE Veterinary Science

Play Episode Listen Later Mar 11, 2022 20:30


Podcast Editor, Tracy Carlson, interviews authors Basel Assaf and Julie Hutt to discuss the article, "Scientific and Regulatory Policy Committee Points to Consider: Nonclinical Research and Development of In Vivo Gene Therapy Products, Emphasizing Adeno-Associated Virus Vector" which can currently be found in Vol 50, Issue 1, 2022 of Toxicologic Pathology. Click here to read the article

DDx
Gene Therapy in Action: Adeno-Associated Viral Vectors

DDx

Play Episode Listen Later Mar 9, 2022 11:31


Adeno-associated viral vectors, or AAVs, are the tiny shells of viruses. And today they are the most common vessels for delivering gene-based therapies.  In this episode, we'll launch into the past, present, and future of AAVs. Imagine a rocket ship blasting off from Earth with cargo bound for a distant space station, and you have a pretty good idea what adeno-associated viral vectors are all about. But instead of ferrying hardware and supplies, AAVs carry genes.It's an achievement nearly six decades in the making. That might seem like a long time to tinker with something smaller than the tiniest single-celled organism. But just like building a rocket ship destined for the deep reaches of space, the development of AAV vectors required patience, persistence, and a few leaps of faith.In the era before DNA sequencing and gene cloning, scientists in the 1960s realized that adeno-associated viral vectors could be a window into understanding genetic variations in viruses – and eventually other organisms, too.The fact that AAVs were immunologically distinct from other viruses made them curious things.So in the 1970s, AAV research took off in three directions. One determined that the simple AAV DNA could be rewritten and edited in a lab. The second found that although these small viruses can infect humans, they don't replicate without a “helper virus” (such as adenovirus). In the absence of another virus, they remain latent, and appear to be of little threat to human health. The third investigated whether AAVs could become vectors for transferring genes from one organism to another. This all culminated in 1978, when the first cloned AAV was generated and was successfully transferred to a cell of the E. coli bacterium, where it produced 50 new colonies of AAVs.So now we had proof that adeno-associated viruses could be artificially produced, that theycould be hollowed out and filled with other genetic material, and that they could potentially bea vector for delivering genes without harming their new host.By the 1980s, we had the capability to build lots of viral rocket ships and fill them with genetic cargo, we just needed a destination to send them. Enter the burgeoning field of gene therapy, with its focus on developing treatments for genetic diseases like cystic fibrosis, hemophilia B, Parkinson's, and more.Research has continued and today, adeno-associated viral vectors are a mainstay of gene therapy development. While progress is necessarily slow, gene therapy is a science that is aiming for the stars. And with AAV vectors, they are now within our reach.For more education on gene therapy, visit www.genetherapynetwork.com.

Let's Talk, Period.
Let's Talk with Carla Anita Mattiazzo | PERIOD. Cabaret Creator and Performer

Let's Talk, Period.

Play Episode Listen Later Feb 15, 2022 51:16


Hey gorgeous people, hope you're having a beautiful Wednesday and are hyped for another LTP ep!  Today's episode is with Carla Anita Mattiazzo. Carla has been gracing the stages of the world for over 30 years, having studied five different performing arts programs and vocal training since age 12. She has been performing cabaret since 2010, and has had multiple shows in the Adelaide Fringe Festival. Carla's show The Catchelorette won the Best Cabaret Weekly award, had rave reviews and sell out shows! This year she is back with a new show, PERIOD ‘ four seasons, one cycle', focused on the menstrual cycle, social justice and period poverty. We chat on: Carla's experiences with periods and period pain growing up Blocking out pain and continuing on in performing arts and the classroom, as a teacherWhat led her to create PERIOD. and the importance behind itThe process of developing and creating a show from start to finish What to expect when coming to see PERIOD. Plus so much more! Thank you so much for listening to this episode of Let's Talk, Period with Carla Anita Mattiazzo.  If you want more from Carla, you can follow her on instagram @carlasconfessionalcabaret. Carla's show, PERIOD. runs from 22 Feb - 6 March as part of the Adelaide Fringe. You can get tickets for in person or online watch at home performances here. $1 from each ticket sale goes towards a charity who helps bleeders in need. Also! If you want to join in on some endo awareness fun next month, join me for our LTP online trivia event! Tickets are just $10 and you can play in a team or solo, and some fabulous prizes are on offer. You can get your ticket here.If you want to keep updated with all things Let's Talk, Period. you can follow us on Instagram at @letstalkperiodau. Don't forget we also have our Let's Talk, Period. Community on facebook. It's the place for people with endo, adeno, pcos or chronic illnesses to ask questions, get support and connect with others who get it! You can join here!Let's Talk, Period. is an independent podcast, so if you did enjoy this episode and want to support the show,  it would be amazing if you could  follow on apple podcasts and leave a rating and review, or if you're listening along on spotify, you can follow the show  and leave a rating!If you want to help grow the Let's Talk, Period. community, you could share this episode with a friend or anyone who you think might enjoy our show or even share that you're listening on your instagram grid or stories! This really helps to find new listeners and build the beautiful LTP podcast community!Your host  is Isabella Gosling (@i_gosling)

Let's Talk, Period.
Let's Talk with Amy Marks | Endo Story + Disability Support Pension Experience

Let's Talk, Period.

Play Episode Listen Later Feb 1, 2022 36:03


Hey, hi, hellooo beautiful soul! Welcome back for another ep of LTP!Today's episode is with Amy Marks. Amy is an endometriosis sufferer, being officially diagnosed in 2020, after experiencing pain and symptoms for over 8 years. She is now studying part time and recently was successful in obtaining the Disability Support Pension. We chat on: Amy's experience being diagnosed with  endo in 2020What she would say to someone who has just been diagnosed with endoThe most challenging aspects of endometriosis and how it impacts her life Tips for studying with a chronic illness Amy's experience being able to get the Disability Support Pension and her advice to someone going through that processI also do a more in depth dive into the Disability Support Pension and the process behind it, including the income and assets test, medical rules and non-medical rules, income limits, evidence needed and the medical assessment to be granted the DSP. I also talk through what happens if you're unsuccessful and what to do next. I mention a few links in the ep, so they're down below for you to check them out, should you wish! DSP Info + Links DSP Pre-Claim Eligibility CheckNon-Medical Rules Medical Rules How Claim is Assessed How to Claim done online or will need:SA466 FormIncome and Assets Form Consent to Disclose Medical Information FormDSP Medical Evidence ChecklistSupporting Documents Thank you so much for listening to this episode of Let's Talk, Period with Amy Marks. If you want to keep updated with all things Let's Talk, Period. you can follow us on Instagram at @letstalkperiodau. Don't forget we also have our Let's Talk, Period. Community on facebook. It's the place for people with endo, adeno, pcos or chronic illnesses to ask questions, get support and connect with others who get it! You can join here!Let's Talk, Period. is an independent podcast, so if you did enjoy this episode and want to support the show,  it would be amazing if you could  follow on apple podcasts and leave a rating and review, or if you're listening along on spotify, you can follow the show  and leave a rating!If you want to help grow the Let's Talk, Period. community, you could share this episode with a friend or anyone who you think might enjoy our show or even share that you're listening on your instagram grid or stories! This really helps to find new listeners and build the beautiful LTP podcast community!Your host  is Isabella Gosling (@i_gosling)

community talk tips period claim disability pcos shameless endo dsp processi ltp wellness collective adeno period podcast life uncut disability support pension healthy hustlers amy marks
Let's Talk, Period.
Let's Talk with Isabella Gosling | My Endo + Adeno Story

Let's Talk, Period.

Play Episode Listen Later Jan 25, 2022 40:27


Happy 2022 LTP fam! Welcome back to season 4 of Let's Talk, Period. I am so excited to be back and have missed putting out content and being in your ears! Today's episode is with me! I talk all about my experience getting diagnosed with endo and adeno and the journey that it took for this to happen. I chat on: My first period experienceWhen I noticed something was wrongEmbarrassing period stories How many specialists it took to get someone to listen to me What it was like to go through this experienceWhat helped me along the way How I'm managing nowThank you so much for listening to this episode of Let's Talk, Period with me (Isabella Gosling). If you want to follow my personal instagram, it's @i_gosling. If you want to keep updated with all things Let's Talk, Period. you can follow us on Instagram at @letstalkperiodau. Don't forget we also have our Let's Talk, Period. Community on facebook. It's the place for people with endo, adeno, pcos or chronic illnesses to ask questions, get support and connect with others who get it! You can join here!Let's Talk, Period. is an independent podcast, so if you did enjoy this episode and want to support the show,  it would be amazing if you could  follow on apple podcasts and leave a rating and review, or if you're listening along on spotify, you can follow the show  and leave a rating! If you want to help grow the Let's Talk, Period. community, you could share this episode with a friend or anyone who you think might enjoy our show or even share that you're listening on your instagram grid or stories! This really helps to find new listeners and build the beautiful LTP podcast community!Your host  is Isabella Gosling (@i_gosling)

Not Cha Momma Pod
Navigating the Holidays Part 1 - Endo & Adeno

Not Cha Momma Pod

Play Episode Listen Later Dec 9, 2021 46:42


Let's talk about chronic illness and finding ways to enjoy the holidays without risking flare ups! The Not Cha Momma Pod shares our top tips! Like, share, and follow us on IG @notchamommapod and tag us in the meditation challenge with the hashtag #movementmedicine. DM any gentle corrections or email us at notchamommapod@gmail.com. Anchor listeners - leave us voice messages at https://anchor.fm/notchamommapod/message.

Sexcess Story
Episode 5: Endometriosis & Adenomyosis: What I Got vs What I'm Willing To Give

Sexcess Story

Play Episode Listen Later Nov 17, 2021 85:20


In episode 5, Heather interviews Hannah Krumreich, who's battled Endo and Adeno for 13 years! She hasn't been able to tell her story until now, and she tells all about her battle with illness, sex, body image, suicide, doctors, surgery after surgery, and finding a way to move from hopeless to hopeful. Hannah does not preach being positive; instead she encourages others to find support, find themselves, and find love, but not where you'd think! In this episode you'll learn: -What is Endometriosis & Adenomyosis; key difference between the two -On overage, how long it takes to get a diagnosis and why -How there is no prevention, no real screening, and no cure -How she learned to deal with chronic illness and how unhealthy it was -What giving up looks like, but how to decide to fight stronger, advocate for yourself and literally move through pain -What it's like viewing sex through the eyes of Endo & Adeno and how she is still figuring this out Feel free to contact Hannah with questions: Instagram @hannah_runs26.2 Email: hannah.krumreich@gmail.com Heather is looking for individuals and couples to tell your story on her podcast! Here is how you can get in touch with her! Instagram: @Sexcess_Story Facebook: Heather DeKeyser-Smith Email: heather.hopetherapeutics@gmail.com

Let's Talk, Period.
Let's Talk with Dr Mikayla Couch | Ob/Gyn Registrar

Let's Talk, Period.

Play Episode Listen Later Oct 12, 2021 30:07


Hey lovely people! I hope you're having a super fab week and are excited for a new ep! Today's episode is with Dr Mikayla Couch. Dr Mikayla Couch is an Obstetrics and Gynaecology Registrar and proud Bundjalung woman who has a keen interest in Indigenous Women's Health. She is passionate about making a difference in the lives of women through providing and advocating for excellent medical care. Through her Instagram account @dr.aboriginal.woman, she continually uses her presence online to provide commentary and create change in the health space. Dr Mikayla is empathetic and strives to provide person centred care through lived experience, suffering from PCOS herself.We chat on: How she keeps herself accountable with goals Mikayla's experience with periods growing up and lack of understanding about periodsBeing diagnosed with PCOS at 27 and coming to terms with that diagnosisWhat drove Mikayla to become a doctor Challenges Aboriginal and Torres Strait Islander people face in healthcareThe impact that the pandemic has had on fertility, fertility treatments and finding a partner The optimal age for egg freezing Thank you so much for listening to this episode of Let's Talk, Period with Dr Mikayla Couch, Obstetrics and Gynaecology Registrar. If you want more from Dr Mikayla, you can follow her on instagram at @dr.aboriginal.woman. If you want to keep updated with all things Let's Talk, Period. you can follow us on Instagram at @letstalkperiodau.ALSO! Join me for the very first Let's Talk, Period. LIVE event on Friday 5 November in Brisbane! Tickets are super limited so book yours ASAP! As a LTP listener, you can use code LTPFAM for $5 off your ticket! Get yours HERELet's talk period is an independent podcast, so if you did enjoy this episode and want to support the show,  it would be amazing if you could  'subscribe' on apple podcasts and leave a rating and review, or if you're listening along on spotify, you can 'follow' the show! If you want to help grow the Let's Talk, Period. community, you could share this episode with a friend or anyone who you think might enjoy our show or even share that you're listening on your instagram grid or stories! This really helps to find new listeners and build the beautiful LTP podcast community!Your host  is Isabella Gosling (@i_gosling)

Living With Endo
Diagnosed with Endo & Adeno at 41 - Amanda Waaldyk's story

Living With Endo

Play Episode Listen Later Oct 6, 2021 20:09


Diagnosed at 41, Endo Champion Amanda Waaldyk joins Ellie Angel-Mobbs to discuss her story living with endometriosis and adenomyosis.

Endo Fertility
EF#40: Functional Fertility Solutions to Male Fertility with Sarah Clark

Endo Fertility

Play Episode Listen Later Oct 6, 2021 62:54


My guest today is Sarah Clark, a health and life coach from Fab Fertile in Canada. In this episode we talk about male fertility. Sarah was 28 years old, when she received a diagnosis of premature ovarian failure. She accepted the diagnosis and had both her children through in vitro fertilization. Years later she realized the root cause of her infertility was a food intolerance. She is a certified life coach with accreditation from the International Coaches Federation and a health coach with training from the Institute for Integrative Nutrition. She is the author of Fabulously Fertile - Supercharge your Fertility Naturally, Fabulously Fertile Cookbook and Fertility Preparation Program. Her fertility coaching program, which includes functional lab testing, supports couples to make diet and lifestyle changes that dramatically improve the chances of a healthy pregnancy and baby! On her Get Pregnant Naturally Podcast she shares that with functional medicine and natural fertility solutions we can eventually reverse infertility. In this episode we talk about: Her own fertility journey with premature ovarian failure and how she was rushed into IVF and egg donation. The importance of reviewing male fertility when trying to conceive Key things that matter with male fertility How functional reference ranges can be used to look understand sperm and overall health How male fertility can be affected by environmental toxins Common health themes that affect male fertility Importance of lifestyle factors like sleep, work and exercise How men often deal or feel with infertility (male and female factor) Emotional support tips for both men and women Nutrition and lifestyle improvements such as environmental exposure The need to find your “love language” and personal needs Recommended supplements and testing for sperm and overall health How the Fab Fertile practitioners use functional medicine to help couples get pregnant Finally, I share what I am working on at the moment and what I will be releasing soon and in the coming months. If you want to be the first to know, then make sure you are on my mailing list: https://endofertilityspecialist.com/endo-fertility-news-mailing-list/ So this is the final episode of Season 2, and there will now be a bit of a break. Season 3 will be out in the New Year. CAN I ASK YOU a FAVOUR? Could you please LEAVE A RATING AND A REVIEW – as this helps spread the love to other women in need. Thank you! Check out my posts on Instagram (@endofertilityspecialist.com) and facebook (@endofertilityspecialist.com). Today's episode is sponsored by the Endo Fertility Resource Library where you can get 3 FREEBIES: E-Book: 5 Things I Learnt to Drop My Pain & Optimise My Fertility, Your Guide to Super Sperm 88 Ways I Dropped My Pain and Got Pregnant ----- Lizzie is a certified nutrition and health coach using a functional and integrative approach, holistic massage therapist, Endometriosis and Adenomyosis sufferer and mother of one. Lizzie works with women with Endo and Adeno to help them find a way to get back to a healthy fertile cycle through her 1:1 coaching programmes. Find out more at endofertilityspecialist.com.

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Let's Talk, Period.
Let's Talk with Tamika Nacson (A.K.A XIRA) | Performing Artist + Endo Advocate | Trigger Warning *Pregnancy Loss*

Let's Talk, Period.

Play Episode Listen Later Oct 5, 2021 45:17


Hellooooo gorgeous people! Today's episode is with the incredibly strong Tamika Nacson, or you may know her as performing artist XIRA. Tamika is an EDM and Pop singer and songwriter with over 20 million streams worldwide. Under the artist name XIRA, Tamika has featured on songs with American DJ 3LAU (Justin Blau) and EDM heavyweight Nicky Romero; and has a new one out in October with Audien. Tamika suffers from endometriosis and after an emergency laparoscopy for an ovarian torsion and PID in 2017, Tamika turned her focus away from performing live and more towards songwriting and recording (things she can do in her own time, in the comfort of her trackies, with a heat pack close by at all times). Chronic illness forced her to reassess and change paths (now working with her chronic illness and not against it) but it has worked out better than ever imagined.We chat on: Tamika's journey to diagnosis for endometriosis in 2010What it was like to need emergency surgery for an ovarian torsionThe decision to pivot away from live performance and the feelings associatedHow Tamika's uses her chronic illnesses in her art as a songwriter The relief Tamika has found with being able to access a disability parking permitHow Tamika deals with people who think she doesn't 'look sick'Plus so much moreDisability Parking Permit Info: QLD NSWACTVICSATASWANTThank you so much for listening to this episode of Let's Talk, Period with Tamika Nacson.  If you want more from Tamika, you can follow her on instagram at @xiramusic and listen to her music on Spotify. If you want to keep updated with all things Let's Talk, Period. you can follow us on Instagram at @letstalkperiodau.ALSO! Join me for the very first Let's Talk, Period. LIVE event! They are super limited so book yours ASAP! Also as a LTP listener, you can use code LTPFAM for $5 off your ticket! Get yours HERELet's talk period is an independent podcast, so if you did enjoy this episode and want to support the show,  it would be amazing if you could  'subscribe' on apple podcasts and leave a rating and review, or if you're listening along on spotify, you can 'follow' the show! If you want to help grow the Let's Talk, Period. community, you could share this episode with a friend or anyone who you think might enjoy our show or even share that you're listening on your instagram grid or stories! This really helps to find new listeners and build the beautiful LTP podcast community! Your host  is Isabella Gosling (@i_gosling)

Let's Talk, Period.
Let's Talk with Ebony Crameri | PCOS, Fertility + Endo Dietitian & Nutritionist

Let's Talk, Period.

Play Episode Listen Later Sep 28, 2021 40:52


Happy Wednesday lovely LTP fam! After a week off, it's so great to be back with a brand new ep! What better way to cap off PCOS Awareness Month than with today's episode, with the amazing Ebony Crameri! Ebony is an Accredited Practising Dietitian and credentialed fertility & prenatal dietitian with 12 years clinical experience as a dietitian. Ebony has a special interest in nutrition for fertility, PCOS and endometriosis who provides online consultations to women across Australia and internationally. Ebony's interest in fertility nutrition first developed after her own struggles with infertility and pregnancy losses. Ebony has turned her journey from infertility to motherhood into her passion and created her online nutrition practice to help women to support their reproductive and hormone health as well as optimise their diet for fertility. We talk on: What led Ebony to become a dietitianWhy birth control is so often prescribed for PCOSEbony's approach when working with people who have PCOSThe role of insulin resistance, low progesterone and elevated cholesterol in PCOSHow to support your body to regulate your cycle and promote consistent ovulationEbony's top three tips for navigating a new diagnosis of PCOSPlus so much more!Thank you so much for listening to this episode of Let's Talk, Period with Ebony Crameri, Accredited Practising Dietitian and Nutritionist. If you want more from Ebony, you can follow her on instagram at @hormone.nutrition or head to her website for more info on the services she provides, you can do this  If you want to keep updated with all things Let's Talk, Period. you can follow us on Instagram at @letstalkperiodau.Let's talk period is an independent podcast, so if you did enjoy this episode and want to support the show,  it would be amazing if you could  'subscribe' on apple podcasts and leave a rating and review, or if you're listening along on spotify, you can 'follow' the show! If you want to help grow the Let's Talk, Period. community, you could share this episode with a friend or anyone who you think might enjoy our show or even share that you're listening on your instagram grid or stories! This really helps to find new listeners and build the beautiful LTP podcast community!  Your host  is Isabella Gosling (@i_gosling)

Van Leer Institute Series on Ideas
Danny Adeno Abebe, "From Africa To Zion" (Miskal, 2021)

Van Leer Institute Series on Ideas

Play Episode Listen Later Aug 31, 2021 54:07


In 1984, in an unprecedented act of brotherhood, Israel airlifted thousands of persecuted and starving Ethiopian Jews from Africa to Israel. They had been waiting in Ethiopia for millennia, sustained by the hope to return home to the Holy Land. Among the refugees was an 8-year-old boy, Danny Adeno Abebe. Now an Israeli journalist, Abebe tells the story of his family and his village, and the journey they traveled from Ethiopia through Sudan to Israel, and the even longer distance from a rural village life without indoor plumbing, electricity, or books, to a modern society. Many who left the villages did not survive the hardships of the journey, and many of those who did reach the Promised Land were emotionally wounded in the process. Immigrants in all times and places struggle with loss. They struggle to understand and adapt to their new country, to find a way to fit in, and to expand their identity to incorporate the old and the new. But few must leap a cultural gap as wide as that which this group faced. In his new country, Adeno Abebe encountered rejection as well as embrace. He experienced both astonishing support and appalling prejudice. As he matured, he recognized that both attitudes exist among his former countrymen in Africa, as well. From Africa To Zion (Miskal, 2021) is an extraordinary life story, but above all—it is a story about people, about love, and about the importance of family, regardless of skin color or ethnicity. Renee Garfinkel, Ph.D. is a psychologist, writer, Middle East television commentator and host of The New Books Network's Van Leer Jerusalem Series on Ideas. Write her at r.garfinkel@yahoo.com. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/van-leer-institute

The Cycle. Endometriosis Podcast
Season 2; Episode 28. Mara, Diagnosed herself at 26, via Google, then she had almost yearly surgeries, and presented Adenomyosis symptoms, 10 years later she finally found a doctor who could help.

The Cycle. Endometriosis Podcast

Play Episode Listen Later Oct 30, 2020 61:46


Mara is 36 years old from WI. She had heavy and long periods starting at 15 years old, at 17 years old she had her first GYN appointment where she was put on Birth Control which helped reduce her cramps, but as years went on in her twenties she began to have increased symptoms such as large blot clots, back pain, pain that felt like contractions and GI symptoms. At 26 she was googling and self-diagnosed with endo... about 6 weeks out from her wedding, 3 weeks before she got married she had surgery! She had back surgery and post-surgery she had bladder retention one month after surgery due to the inflammation of her uterus. Over the next 10 years, she had surgery, changed her diet, and was diagnosed with Adeno. Listen to the rest of her journey on the show. Want to keep the conversation going? Join our Facebook Group: tiny.cc/7mpbnz Thank you for listening and supporting this podcast. We need awareness about this disease. If you want to be on the podcast or have feedback please reach out via my website www.melissaboudreau.com. Thank you for your support and time. Please consider subscribing and writing us a review on Apple podcasts it really helps us get more awareness and with guests agreeing to come on! You can do that here! http://tiny.cc/f74onzSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.