Podcasts about statin use

Dr. Cate Shanahan returns to share vital insights on the dangers of seed oils and their impact on health. As a well-known Cornell-trained physician and author, Dr. Cate has spent years researching and advocating against the use of harmful vegetable oils. In this episode you'll learn about the "Hateful Eight" oils and why they are detrimental to metabolic health. Dr. Cate explains the connection between these oils and chronic diseases, such as heart disease and diabetes. You will understand how to read labels to avoid these oils in everyday foods and get practical tips for making healthier dietary choices. Dr. Cate also covers the history and influence of the American Heart Association on dietary recommendations, revealing some eye-opening truths. Key takeaways you'll gain include understanding the role of oxidative stress, the importance of choosing the right fats for a healthy diet, and how avoiding these oils can improve overall well-being.Timestamps: 00:00:00 — Opening 00:01:46 — Welcome and Introduction of Dr. Cate Shanahan 00:02:34 — The Reality of Food Deserts and Vegetable Oils 00:04:01 — The Ultra Wealthy and Their Dietary Choices 00:05:42 — Dr. Cate's Personal Journey to Understanding Fats 00:11:10 — The Benefits of Avoiding Seed Oils 00:12:08 — The Hateful Eight Oils 00:19:07 — American Heart Association and Proctor & Gamble 00:28:15 — The Importance of Avoiding Oxidized Oils 00:39:05 — Clarifying Misconceptions About Omega-6 00:50:18 — The Impact of Diet on Family Structures 01:00:24 — The Role of Testosterone and Endocrine Disruptors 01:15:29 — Understanding Insulin Resistance 01:25:00 — The Slippery Slope of Statin Use 01:45:00 — Practical Tips for Avoiding Vegetable Oils 01:52:01 — Conclusion Sponsors: ARMRA | Go to TryARMRA.com and use the code DAVE to get 15% off your first order. Leela Quantum | Visit LeelaQ.com/Dave for 10% off. Resources: Dr. Cate's book, “Dark Calories” is out now! Learn more about Dr. Cate: https://drcate.com/ Dr. Cate's Instagram: @drcaseyskitchen Levels' Instagram: @DrCateShanahan Dave Asprey's book ‘Smarter Not Harder' is out now: https://daveasprey.com/books Follow Dave on Instagram: @Dave.Asprey Follow The Human Upgrade: @TheHumanUpgradePodcast Want to join The Human Upgrade Podcast Live? Join Our Upgrade Collective: https://www.ourupgradecollective.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Hour 1 of The Drew Mariani Show on 5-29-24 (originally aired 4-3-24) Dr. Sean O'Mara joins us all hour to talk about the use of Statins and getting your cholesterol in check – many callers advocate for changing diet and increasing exercise instead of taking the drug, but some folks have to due to hereditary cholesterol problems

Hour 3 of The Drew Mariani Show on 4-3-24 Dr. Sean O'Mara joins us all hour to talk about the use of Statins and getting your cholesterol in check – many callers advocate for changing diet and increasing exercise instead of taking the drug, but some folks have to due to hereditary cholesterol problems

Though statins have been used for decades to fight heart disease, new research suggests an opposite effect: long-term statin use could actually be accelerating heart failure. “Statins impair the production of vitamin K, an essential vitamin in managing calcification,” reports The Epoch Times. “The researchers conclude statin side effects, including statin cardiomyopathy, ‘are far more common than previously published…'” Emily Kaplan has spent over 17 years as an investigative journalist covering topics including violent crime, technology, and health. She has written and produced for The New York Times, The Boston Globe, Boston Magazine, The Daily Beast, New York Daily News, 20/20, Primetime, and Good Morning America. She has a Bachelor's Degree in History and Psychology from Smith College and a Master's in Journalism from the Northwestern Medill School. Emily is a cofounder of The Broken Science Initiative, whose mission is to help “identify and object to the tyranny of bad science” in a world where “consensus has replaced predictive value in academic science, definitions have become subjective, and replication is no longer a requirement.” Follow her at https://x.com/emilykumler and learn more at https://BrokenScience.org 「 SPONSORED BY 」 Find out more about the companies that make this show possible and get special discounts on amazing products at https://drdrew.com/sponsors • PROVIA - Dreading premature hair thinning or hair loss? Provia uses a safe, natural ingredient (Procapil) to effectively target the three main causes of premature hair thinning and hair loss. Susan loves it! Get an extra discount at https://proviahair.com/drew • PALEOVALLEY - "Paleovalley has a wide variety of extraordinary products that are both healthful and delicious,” says Dr. Drew. "I am a huge fan of this brand and know you'll love it too!” Get 15% off your first order at https://drdrew.com/paleovalley • GENUCEL - Using a proprietary base formulated by a pharmacist, Genucel has created skincare that can dramatically improve the appearance of facial redness and under-eye puffiness. Get an extra discount with promo code DREW at https://genucel.com/drew • COZY EARTH - Susan and Drew love Cozy Earth's sheets & clothing made with super-soft viscose from bamboo! Use code DREW for a huge discount at https://drdrew.com/cozy • THE WELLNESS COMPANY - Counteract harmful spike proteins with TWC's Signature Series Spike Support Formula containing nattokinase and selenium. Learn more about TWC's supplements at https://twc.health/drew 「 MEDICAL NOTE 」 Portions of this program may examine countervailing views on important medical issues. Always consult your personal physician before making any decisions about your health. 「 ABOUT THE SHOW 」 Ask Dr. Drew is produced by Kaleb Nation (https://kalebnation.com) and Susan Pinsky (https://twitter.com/firstladyoflove). This show is for entertainment and/or informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment. 「 ABOUT DR. DREW 」 Dr. Drew is a board-certified physician with over 35 years of national radio, NYT bestselling books, and countless TV shows bearing his name. He's known for Celebrity Rehab (VH1), Teen Mom OG (MTV), The Masked Singer (FOX), multiple hit podcasts, and the iconic Loveline radio show. Dr. Drew Pinsky received his undergraduate degree from Amherst College and his M.D. from the University of Southern California, School of Medicine. Read more at https://drdrew.com/about Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Popper discusses the myth of genetics determining health outcomes. She emphasizes the power of diet and lifestyle in shaping our health, explaining how these factors often have a more significant impact on health outcomes than genetic predisposition.

In this episode of the Health Edge I review a recent meta-analysis examining the magnitude of cardiovascular benefit from taking statins for elevated LDL in both primary and secondary prevention.JAMA Intern Med. 2022;182(5):474-481. doi:10.1001/jamainternmed.2022.0134 Published online March 14, 2022. https://pubmed.ncbi.nlm.nih.gov/35285...

Lege Sjur Even Aunmo er opptatt av å følge med på forskning. I denne episoden forteller han om problemene med å leve av planter. Planter har nemlig forsvarsmekanismer mot å bli spist. De kan dessuten stjele mineraler, trigge immunsystemet, tilføre tungmetall og gi næring til kreft. Selv foretrekker han et kosthold bestående utelukkende av animalske produkter. Han synes det er beklagelig at rådene har blitt politiske gjennom at de har tatt inn klimasaken, fremfor at de er en mest mulig sann fremstilling av hva ulike typer mat gjør med kroppen. Aunmo legger frem forskningsevidens som peker i motsatt retning av kostholdsrådene norske myndigheter har lagt frem nylig. Han har mange suksesshistorier fra pasienter med autoimmune sykdommer, diabetes og andre sykdommer, som har blitt friske etter at de sluttet å spise bestemte typer planter, produkter fra planter eller utelukket dem helt fra kosten.Sjur Even Aunmo: • youtube.com • facebook.comGrønnsaker uten noen kjent form for gluten: • hodekål, blomkål, brokkoli, paprika, rødbeter, bladbete, squash, potet, søtpotet, gulrøtter, gresskar, romano-salat, indisk bladsennep, spinat, grønnkål • Obs: Selv om disse plantene ikke inneholder gluten, finnes det andre stoffer i dem som er uheldige. Paprika, for eksempel, hører til søtvier-familien, sammen med potet og tobakk. De forsvarer seg mot mennesker, dyr og insekter med lektiner og solanin. Spinat inneholder mye oksalat som stjeler kalsium fra kroppen. Det finnes igjen i nyrestener og mistenkes for å stimulere brystkreft. Grønnsaker inneholder druesukker, som er et viktig næringsstoff for kreft. Grønnsaker som vokser over bakken inneholder ofte mindre sukker enn de som vokser under bakken. De minst usunne grønnsakene på listen synes å være hodekål, blomkål og brokkoli, på tross av at disse danner goitrin, et stoff som motvirker dannelsen av stoffskiftehormon.Diverse kilder: • Mindre kjøtt, mer plantebasert: Her kommer De nordiske ernæringsanbefalingene 2023 • Helsedirektoratets kostråd • The Seven Countries Study (søk) • Paleo diet (søk) • Keto diet (søk) • Carnivore diet (søk)› Relaterte AJP-episoder: • AJP 61 | Sjur Even Aunmo – Fikk sparken for å snakke om bivirkningerRelatert forskning:› FETT› https://doi.org/10.1136/bmj.e8707 Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis› https://doi.org/10.1136/bmj.i1246 Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73)› https://doi.org/10.3945/ajcn.2009.27725 Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease› https://doi.org/10.1186/s12937-017-0254-5 The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials› https://doi.org/10.1016/j.jacc.2020.05.077 Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review› http://dx.doi.org/10.1136/openhrt-2014-000196 Evidence from randomised controlled trials did not support the introduction of dietary fat guidelines in 1977 and 1983: a systematic review and meta-analysis› http://dx.doi.org/10.1136/bmjebm-2019-111180 Fat or fiction: the diet-heart hypothesis› https://www.mn.uio.no/ibv/tjenester/kunnskap/plantefys/leksikon/h/herdet-fett.html› https://doi.org/10.1046/j.1471-4159.1997.68052092.x 4-Hydroxynonenal-Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease› https://doi.org/10.1016/j.freeradbiomed.2006.07.021 Induction of mitochondrial nitrative damage and cardiac dysfunction by chronic provision of dietary ω-6 polyunsaturated fatty acids› https://doi.org/10.1038/s41467-018-05614-6 Dietary stearic acid regulates mitochondria in vivo in humans› http://dx.doi.org/10.17140/AFTNSOJ-1-123 Oxidation of Polyunsaturated Fatty Acids and its Impact on Food Quality and Human Health› https://doi.org/10.1194/jlr.M026179 Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells› https://doi.org/10.1021/jf049207s Effect of the Type of Frying Culinary Fat on Volatile Compounds Isolated in Fried Pork Loin Chops by Using SPME-GC-MS› STATINER (KOLESTEROLSENKENDE STOFFER)› http://dx.doi.org/10.1136/bmjopen-2018-023085 Statins for the primary prevention of cardiovascular disease: an overview of systematic reviews› http://dx.doi.org/10.1136/bmjopen-2014-007118 The effect of statins on average survival in randomised trials, an analysis of end point postponement› https://doi.org/10.1001/archinternmed.2010.182 Statins and All-Cause Mortality in High-Risk Primary Prevention: A Meta-analysis of 11 Randomized Controlled Trials Involving 65 229 Participants› https://www.felleskatalogen.no/medisin/lipitor-upjohn-eesv-pfizer-560999› https://www.felleskatalogen.no/medisin/zocor-organon-565655› https://www.legemiddelhandboka.no/L8.15.1/Statiner› https://www.bmj.com/campaign/statins-open-data Statins - a call for transparent data› https://doi.org/10.1001/archinternmed.2011.625 Statin Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women's Health Initiative› https://doi.org/10.1007/s40264-017-0620-4 Amyotrophic Lateral Sclerosis Associated with Statin Use: A Disproportionality Analysis of the FDA's Adverse Event Reporting System› https://doi.org/10.1001/jamainternmed.2020.6084 Evaluation of Time to Benefit of Statins for the Primary Prevention of Cardiovascular Events in Adults Aged 50 to 75 Years› https://doi.org/10.1016/j.atherosclerosis.2022.07.003 Statin therapy for the primary prevention of cardiovascular disease: Cons› http://doi.org/10.1161/STROKEAHA.121.034576 Lipid-Lowering Therapy and Hemorrhagic Stroke RiskLipid-Lowering Therapy and Hemorrhagic Stroke Risk› KJØTT› https://www.acpjournals.org/doi/full/10.7326/M19-0622 Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes A Systematic Review of Randomized Trials› https://doi.org/10.3945/ajcn.116.142521 Total red meat intake of ≥0.5 servings/d does not negatively influence cardiovascular disease risk factors: a systemically searched meta-analysis of randomized controlled trials› https://doi.org/10.3945/ajcn.113.062638 Meat intake and cause-specific mortality: a pooled analysis of Asian prospective cohort studies› FISK› https://doi.org/10.1093/jn/nxab112 Biomarkers and Fatty Fish Intake: A Randomized Controlled Trial in Norwegian Preschool Children› https://doi.org/10.1007/s12016-013-8363-1 Fish Allergy: In Review› KOLESTEROL› http://dx.doi.org/10.1136/bmjopen-2015-010401 Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review› https://doi.org/10.1016/j.mehy.2018.09.019 Inborn coagulation factors are more important cardiovascular risk factors than high LDL-cholesterol in familial hypercholesterolemia› PMID: 18277343 ApoB/ApoA1 ratio and subclinical atherosclerosis› https://doi.org/10.1016/0021-9150(89)90130-5 Cigarette smoking renders LDL susceptible to peroxidative modification and enhanced metabolism by macrophages› https://doi.org/10.1161/01.CIR.93.7.1346 Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia: Role of Oxidized LDL› https://doi.org/10.1161/01.CIR.97.20.2012 Passive Smoking Induces Atherogenic Changes in Low-Density Lipoprotein› https://doi.org/10.1016/j.atherosclerosis.2008.04.046 Smoking and smoking cessation—The relationship between cardiovascular disease and lipoprotein metabolism: A review› https://doi.org/10.1161/ATVBAHA.113.300156 Smoking and Cardiovascular Disease› https://doi.org/10.3402/fnr.v59.29240 LDL biochemical modifications: a link between atherosclerosis and aging› https://doi.org/10.1016/j.cjca.2017.07.015 Association Between Circulating Oxidized LDL and Atherosclerotic Cardiovascular Disease: A Meta-analysis of Observational Studies› https://doi.org/10.1054/plef.2000.0204 Why is glycated LDL more sensitive to oxidation than native LDL? A comparative study.› KARBOHYDRAT› https://www.helsedirektoratet.no/rapporter/anbefalinger-om-kosthold-ernaering-og-fysisk-aktivitet/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf/_/attachment/inline/2f5d80b2-e0f7-4071-a2e5-3b080f99d37d:2aed64b5b986acd14764b3aa7fba3f3c48547d2d/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf› FRUKTOSE› https://doi.org/10.1016/j.jhep.2021.02.027 Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial› https://doi.org/10.1093/ajcn/nqaa332 Effects of fructose restriction on liver steatosis (FRUITLESS); a double-blind randomized controlled trial› https://doi.org/10.5223/pghn.2021.24.5.483 The Relationship between Daily Fructose Consumption and Oxidized Low-Density Lipoprotein and Low-Density Lipoprotein Particle Size in Children with Obesity› KUNSTIG SØTNING› https://doi.org/10.1016/s0378-8741(99)00081-1 Effects of chronic administration of Stevia rebaudiana on fertility in rats› https://doi.org/10.1371/journal.pone.0000698 Intense Sweetness Surpasses Cocaine Reward› https://doi.org/10.1016/j.cell.2022.07.016 Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance› https://doi.org/10.1289/ehp.8711 First Experimental Demonstration of the Multipotential Carcinogenic Effects of Aspartame Administered in the Feed to Sprague-Dawley Rats› https://doi.org/10.1289/ehp.10271 Life-Span Exposure to Low Doses of Aspartame Beginning during Prenatal Life Increases Cancer Effects in Rats› DIABETES› https://doi.org/10.1001/jama.295.6.655 Low-Fat Dietary Pattern and Risk of Cardiovascular DiseaseThe Women's Health Initiative Randomized Controlled Dietary Modification Trial – se side 661, økt hjerte/kar-risk sfa. Lavfett-diett› https://doi.org/10.3945/ajcn.110.010843 Effects of a low-fat dietary intervention on glucose, insulin, and insulin resistance in the Women's Health Initiative (WHI) Dietary Modification trial› https://doi.org/10.1007/s11745-008-3274-2 AOCS Lipids (lavranket journal) Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet› https://doi.org/10.1161/ATVBAHA.114.303284 Small Dense Low-Density Lipoprotein-Cholesterol Concentrations Predict Risk for Coronary Heart Disease- ArtThromVas prospektiv kohort› https://doi.org/10.1097/MOL.0b013e328306a057 Glycation as an atherogenic modification of LDL : Current Opinion in Lipidology› https://doi.org/10.1016/0021-9150(93)90084-8 Glycosylated low density lipoprotein is more sensitive to oxidation: implications for the diabetic patient?› https://doi.org/10.2337/diabetes.55.02.06.db05-1103 Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo› https://doi.org/10.1016/S0895-7061(00)01260-7 Blood viscosity and blood pressure: role of temperature and hyperglycemia› https://doi.org/10.2337/dc13-1374 Blood Viscosity in Subjects With Normoglycemia and Prediabetes› https://doi.org/10.1007/s00592-017-1004-z Elevated 1-h post-challenge plasma glucose levels in subjects with normal glucose tolerance or impaired glucose tolerance are associated with whole blood viscosity› https://doi.org/10.1080/09674845.2010.11730293 Blood viscosity at different stages of diabetes pathogenesis.› DIABETES-DEMENS› https://doi.org/10.1212/WNL.53.9.1937 Diabetes mellitus and the risk of dementia - The Rotterdam Study› https://doi.org/10.1016/S1474-4422(05)70284-2 Lancet Neurology 2006, sysrew lavere evidensgrad. Risk of dementia in diabetes mellitus: a systematic review› https://doi.org/10.1111/j.1445-5994.2012.02758.x Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies› https://doi.org/10.1016/j.arr.2019.100944 Diabetes mellitus and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 144 prospective studies› https://doi.org/10.1177/193229680800200619 Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed› https://doi.org/10.3390/ijerph120708281 Evaluating the Association between Diabetes, Cognitive Decline and Dementia› https://doi.org/10.3390/ijms21030934 Ketone Bodies Promote Amyloid-β1–40 Clearance in a Human in Vitro Blood–Brain Barrier Model› https://doi.org/10.1038/s41574-018-0048-7 Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications› https://doi.org/10.1038/s41586-020-2247-3 APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline› DIABETES NYRESYKDOM› https://doi.org/10.2337/diacare.27.2007.S79 Nephropathy-in-Diabetes Nephropathy in Diabetes› Diabetic Nephropathy: Diagnosis, Prevention, and Treatment› https://doi.org/10.1016/S0272-6386(96)90538-7 Diabetic nephropathy in type II diabetes› DIABETES ØYESYKDOM› https://doi.org/10.1016/S0140-6736(09)62124-3 Diabetic retinopathy› https://doi.org/10.1016/S2213-8587(18)30128-1 Incidence and progression of diabetic retinopathy: a systematic review› DIABETES HJERTE- OG KAR-SYKDOM› https://doi.org/10.1001/jamacardio.2020.7073 Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident Coronary Heart Disease in Women› PLANTE-ANTINÆRINGSSTOFF, VERN OG GIFT› https://doi.org/10.1016/j.foodchem.2008.01.056 Food Chemistry 2008 Bioaccessibility of Ca, Mg, Mn and Cu from whole grain tea-biscuits: Impact of proteins, phytic acid and polyphenols› https://doi.org/10.1002/mnfr.200900099 Phytate in foods and significance for humans: food sources, intake, processing, bioavailability, protective role and analysis.› https://doi.org/10.1046/j.1440-6047.1999.00038.x Oxalate content of foods and its effect on humans› https://doi.org/10.1104/pp.109.2.347 Lectins as plant defense proteins.› https://doi.org/10.1016/j.taap.2009.03.012 Effects of wheat germ agglutinin on human gastrointestinal epithelium: Insights from an experimental model of immune/epithelial cell interaction› https://doi.org/10.1038/s41531-018-0066-0 Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat› https://doi.org/10.1016/S0140-6736(05)79894-9 Identification of intact peanut lectin in peripheral venous blood› https://doi.org/10.1136/bmj.318.7190.1023 Do dietary lectins cause disease?› https://doi.org/10.1016/S0015-0282(16)54596-8 Lectin binding of endometrium in women with unexplained infertility› https://doi.org/10.1016/S0271-5317(88)80133-7 Changes in organs and tissues induced by feeding of purified kidney bean (Phaseolus vulgaris) lectins› https://doi.org/10.3390/molecules20022014 Insecticidal Activity of Plant Lectins and Potential Application in Crop Protection› https://doi.org/10.1210/endo-113-6-1921 Bound Lectins that Mimic Insulin Produce Persistent Insulin-Like Activities› https://doi.org/10.1042/BJ20071137 Contribution of leptin receptor N-linked glycans to leptin binding› https://doi.org/10.1111/j.1365-2249.2007.03368.x Potato lectin activates basophils and mast cells of atopic subjects by its interaction with core chitobiose of cell-bound non-specific immunoglobulin E› https://doi.org/10.1002/(SICI)1521-4141(199903)29:03 Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils› https://doi.org/10.1016/j.ekir.2018.07.020 Secondary Oxalate Nephropathy: A Systematic Review› http://dx.doi.org/10.1136/gut.16.3.193 The effect of tea on iron absorption.› PMID: 1862 Disler PB, Lynch SR, Torrance JD, et al. The mechanism of the inhibition of iron absorption by tea. The South African Journal of Medical Sciences. 1975 ;40(4):109-116.› https://doi.org/10.1016/0887-2333(95)00113-1 Effects of saponins and glycoalkaloids on the permeability and viability of mammalian intestinal cells and on the integrity of tissue preparationsin vitro› https://doi.org/10.1079/BJN2002725 The biological action of saponins in animal systems: a review› http://doi.org/10.1093/carcin/bgp082 Lung tumor promotion by curcumin› https://doi.org/10.3945/ajcn.2009.26736M Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford)› https://doi.org/10.3382/ps.0550716 Antithyroid Activity of Goitrin in Chicks› https://doi.org/10.1016/s0278-6915(82)80294-9 Hepatic effects of R-goitrin in in Sprague-Dawley rats› https://doi.org/10.1002/ana.24448 Vagotomy and subsequent risk of Parkinson's disease --> https://doi.org/10.1038/s41531-018-0066-0› Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat› http://doi.org/10.1056/NEJMra2010852 Salicylate Toxicity› https://doi.org/10.1021/jf0113070 Relationship between Cyanogenic Compounds in Kernels, Leaves, and Roots of Sweet and Bitter Kernelled Almonds› https://doi.org/10.1179/146532810X12637745451951Cyanide poisoning caused by ingestion of apricot seeds› https://doi.org/10.3390/toxins11060324 Ricin: An Ancient Story for a Timeless Plant Toxin› https://doi.org/10.1016/j.taap.2009.03.012Effects of wheat germ agglutinin on human gastrointestinal epithelium: Insights from an experimental model of immune/epithelial cell interaction› GLUTEN› https://doi.org/10.1080/00365520500235334 Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines› https://doi.org/10.1053/j.gastro.2008.03.023 Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3› https://doi.org/10.1016/j.jprot.2017.03.026 A curated gluten protein sequence database to support development of proteomics methods for determination of gluten in gluten-free foods› https://doi.org/10.1111/jgh.13703 What is gluten?› https://doi.org/10.1186/s41043-015-0032-y The opioid effects of gluten exorphins: asymptomatic celiac disease› https://doi.org/10.1016/j.peptides.2015.07.013 Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects› SOYA› https://doi.org/10.1271/bbb.70516Soymorphins, novel μ opioid peptides derived from soy β-conglycinin β-subunit, have anxiolytic activities.› TILSETNINGSSTOFFER› https://doi.org/10.3233/NHA-170023 A randomized trial of the effects of the no-carrageenan diet on ulcerative colitis disease activity› https://doi.org/10.1053/j.gastro.2021.11.006 Randomized Controlled-Feeding Study of Dietary Emulsifier Carboxymethylcellulose Reveals Detrimental Impacts on the Gut Microbiota and Metabolome› https://doi.org/10.1002/ijc.21925 Processed meat consumption, dietary nitrosamines and stomach cancer risk in a cohort of Swedish women› KETOGENISITET/KREFT› https://oslo-universitetssykehus.no/behandlinger/pet-undersokelse› https://stanfordhealthcare.org/medical-tests/p/pet-scan/what-to-expect.html› https://www.sciencedirect.com/topics/medicine-and-dentistry/warburg-effect› https://doi.org/10.1016/j.tibs.2015.12.001 The Warburg Effect: How Does it Benefit Cancer Cells?› https://doi.org/10.1080/01635581.2019.1650942 Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study› https://doi.org/10.1093/jnci/djs399 Dietary Glycemic Load and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings From CALGB 89803› https://doi.org/10.18632/aging.101382 Ketogenic diet in cancer therapy› IATROGENISITET› https://doi.org/10.1111/eci.12834 How to survive the medical misinformation mess› https://doi.org/10.1111/jlme.12068 Institutional Corruption of Pharmaceuticals and the Myth of Safe and Effective Drugs› https://doi.org/10.1136/bmj.f3830 Why we can't trust clinical guidelines› https://doi.org/10.1016/S0140-6736(15)60696-1 Offline: What is medicine's 5 sigma?› https://apjcn.nhri.org.tw/server/apjcn/procnutsoc/1990-1999/1995/1995%20p1-10.pdfLast ned episodenInnspilt: 2023-07-18Publisert: 2023-07-28Støtte Antijantepodden?Liker du arbeidet vi gjør, og vil bidra til at vi lager flere episoder?Finn ut hvordan du kan gi noe tilbake ved å gå til antijantepodden.com!Meld deg på vårt nyhetsbrev

Drs. Yuenger and January walk you though the incidence, risk factors and potential mitigation of primary graft dysfunction in lung transplantation; including the impact of statin use. Full text of the manuscript is available at: https://accpjournals.onlinelibrary.wiley.com/doi/10.1002/phar.2770.

Episode 112: Statins in Primary CareDr. Tiwana explains the use of statins for the primary prevention of cardiovascular disease.Written by Ripandeep Tiwana, MD (Post-Doctoral Research Fellow at Cedar Sinai Medical Center – Heart Institute). Edition of text and comments by Hector Arreaza, MD.____________________________________________You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Definition.Statins commonly referred to as lipid-lowering medications, are important in primary care as they serve multiple long-term benefits than just lipid lowering alone. They are HMG-CoA reductase inhibitors. As a refresher, this is the rate-controlling enzyme of the metabolic pathway that produces cholesterol. This enzyme is more active at night, so statins are recommended to be taken at bedtime instead of during the day. Statins are most effective at lowering LDL cholesterol. However, they also help lower triglycerides and raise HDL cholesterol.Statins are not limited to just patients with hyperlipidemia. They reduce illness and mortality in those who have diabetes, have a history of cardiovascular disease (including heart attack, stroke, peripheral arterial disease), or are simply at high risk for cardiovascular disease. Statins are used for primary and secondary prevention.Types of statins.How do we determine which statin our patients need?First, we need to know that not all statins are created equal. They vary by intensity and potency thus, and they are categorized as either low, moderate, or high intensity.Several statins are available for use in the United States. They include Atorvastatin (Lipitor), Fluvastatin (Lescol XL), Lovastatin (Altoprev), Pitavastatin (Livalo, Zypitamag), Pravastatin (Pravachol), Rosuvastatin (Crestor, Ezallor), Simvastatin (Zocor)Commonly used in clinics: Simvastatin, Atorvastatin, and Rosuvastatin.Statin Dosing and ACC/AHA Classification of Intensity                                  Low-intensity                                   Moderate-intensity                                     High-intensityAtorvastatin              NA 1                                                          10 to 20 mg                                                   40 to 80 mgFluvastatin                20 to 40 mg                                          40 mg 2×/day; XL 80 mg                                NALovastatin                 20 mg                                                       40 mg                                                                         NAPitavastatin               1 mg                                                          2 to 4 mg                                                                   NARosuvastatin             NA                                                            5 to 10 mg                                                          20 to 40 mgSimvastatin                10 mg                                                      20 to 40 mg                                                             NAOf note, atorvastatin and rosuvastatin are only for moderate or high-intensity use, and do not use simvastatin 80 mg.Identifying patients at risk.How do we determine who needs statin therapy?Once we become familiar with the different statins, we must figure out which intensity is advised for our patient. Recommendations for statin therapy are based on guidelines from The U.S. Preventive Services Task Force (USPSTF), American Diabetes Association (ADA), and the American College of Cardiology/American Heart Association (ACC/AHA) which recommend utilizing the ASCVD risk calculator in those patients who do not already have established cardiovascular disease.ASCVD stands for atherosclerotic cardiovascular disease, defined as coronary heart disease, cerebrovascular disease, or peripheral arterial disease presumed to be of atherosclerotic origin. ASCVD remains a leading cause of morbidity and mortality in the United States, especially in individuals with diabetes.The ASCVD risk score determines a patient's 10-year risk of cardiovascular complications, such as a myocardial infarction or stroke. This risk estimate considers age, sex, race, cholesterol levels, use of blood pressure medication, diabetic status, and smoking status. Regarding age, this calculator only applies to the age range of 40-79 as there is insufficient data to predict risk outside this age group.There are several online and mobile applications available to calculate this score. Once calculated it gives a recommendation for which intensity statin to use. However, as this is a recommendation, it is essential to use your own clinical judgment to decide what is best for your individual patient. Please refer to the above table as a reference for which statin and dose you may consider using.Keeping the above calculator in mind, additional statin guidelines are recommended by the ACC:Patients ages 20-75 years and LDL-C ≥190 mg/dl use high-intensity statin without risk assessment. (You do not need the calculator.)People with type 2 diabetes and aged 40-75 years use moderate-intensity statins, and risk estimate to consider high-intensity statins. (It means moderate for all diabetics older than 40, high for some.)Age >75 years, clinical assessment, and risk discussion. Age 40-75 years and LDL-C ≥70 mg/dl and 10%. Grade B recommendation: prescribe a statin for the primary prevention of CVD.Grade C – 40-75 years with >= 1 cardiovascular risk factor AND estimated 10-year ASCVD risk 7.5-10%. Grade C recommendation: selectively offer a statin for the primary prevention of CVD. The likelihood of benefit is smaller in this group than in persons with a 10-year risk of 10% or greater.Grade I - The USPSTF found insufficient evidence to recommend for or against initiating a statin for the primary prevention of CVD events and mortality in adults 76 years or older.The USPSTF is also very clear regarding the intensity of statin therapy. They explained that there is limited data directly comparing the effects of different statin intensities on health outcomes. Most of the trials they reviewed used moderate-intensity statin therapy. They conclude that moderate-intensity statin therapy seems reasonable for most persons' primary prevention of CVD.The USPSTF has a broader recommendation, whereas the ACC guidelines are more detailed and individualized and provide guidance on the recommended intensity of statin therapy.Labs needed.Establish baseline labs for serum creatinine, LFTs, and CK only if there is a myopathy risk. Routine monitoring of LFTs, serum creatinine, and CK is unnecessary; only check if clinically indicated.A lipid panel should be checked in 6-8 weeks, and the patient should monitor themselves for any side effects, including myalgias. If LDL-C reduction is adequate (≥30% reduction with intermediate statins and 50% with high-intensity statins), regular interval monitoring of risk factors and compliance with statin therapy is necessary to sustain long-term benefit.Side effects and contraindications.Some common side effects include URI-like symptoms, headache, UTI, and diarrhea. Some patients are very hesitant to take any medications. Warning about side effects may decrease compliance. Major  contraindications for statin therapy include active liver disease, muscle disorders, pregnancy, and breastfeeding.Special considerations.Chronic kidney disease: The preferred statins for CKD with severe renal impairment are atorvastatin and fluvastatin because they do not require dose adjustment. Pravastatin would be a second choice.Chronic liver disease: Statins are contraindicated in patients with decompensated cirrhosis or acute liver failure. Abstinence from alcohol is critical in patients with chronic liver disease who are taking statins. Pravastatin and rosuvastatin are the preferred agents. Check lipid levels to determine if LDL-C reduction is accomplished with no changes in aminotransferases. You may consider stopping, increasing dose, or changing statin as you discuss the risks vs. benefits with your patient.Conclusion: Simply put, if a patient has an LDL of greater than 190, is a diabetic, has an established history of cardiovascular disease, or is at risk for it, then the patient should ideally be taking a statin unless there is a contraindication, allergy, or other special circumstance that limits him/her from doing so. If you have patients that apply to any of the above scenarios and are not already on a statin, determine their risk, and consider starting them on a statin “stat” to reduce morbidity and mortality. On the other hand, be mindful of overprescribing. Do not prescribe statins to patients who do not meet the above criteria.________________________________________Now we conclude our episode number 113, “Statins in Primary Care.” Statins are powerful medications for the prevention of cardiovascular disease. Do not forget to recommend non-pharmacologic measures such as healthy eating and physical activity, but let's also consider adding a statin to patients who are at moderate to high risk for cardiovascular disease.This week we thank Hector Arreaza and Ripandeep Tiwana. Audio by Adrianne Silva.Even without trying, every night, you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you; send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week!______________________________________References:1. Statins, U.S. Food & Drug Administration, 2014, December 16, fda.gov, https://www.fda.gov/drugs/information-drug-class/statins, accessed September 14, 2022.2. Chou R, Cantor A, Dana T, et al. Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: A Systematic Review for the U.S. Preventive Services Task Force [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2022 Aug. (Evidence Synthesis, No. 219.) Available from: https://www.ncbi.nlm.nih.gov/books/NBK583661/3. 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol 2019; March 17. https://www.acc.org/latest-in-cardiology/ten-points-to-remember/2019/03/07/16/00/2019-acc-aha-guideline-on-primary-prevention-gl-prevention. 4. ASCVD Risk Estimator Plus, published by the American College of Cardiology, https://tools.acc.org/ascvd-risk-estimator-plus/#!/calculate/estimate/, accessed September 14, 2022.5. Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Preventive Medication, U.S. Preventive Services Task Force, Final Recommendation Statement, 2022, August 23. https://uspreventiveservicestaskforce.org/uspstf/recommendation/statin-use-in-adults-preventive-medication6.  Videvo. “Distinction.” Https://Www.videvo.net/Royalty-Free-Music-Track/Distinction/227882/, Https://Www.videvo.net/, https://www.videvo.net/royalty-free-music-track/distinction/227882/. Accessed 26 Sept. 2022.

Editor's Summary by Kirsten Bibbins-Domingo, PhD, MD, MAS, Editor in Chief of JAMA, the Journal of the American Medical Association, for the August 23/30, 2022 issue.  

Interview with John B. Wong, MD, USPSTF member and coauthor of Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Statin Use for the Primary Prevention of Cardiovascular Disease in Adults Statin Use for the Primary Prevention of Cardiovascular Disease in Adults Statins for the Prevention of Cardiovascular Disease Statin Usage in Primary Prevention—Comparing the USPSTF Recommendations With the AHA/ACC/Multisociety Guidelines Statins for Primary Cardiovascular Disease Prevention Statins and Primary Atherosclerotic Cardiovascular Disease Prevention—What We Know, Where We Need to Go, and Why Are We Not There Already?

Commentary by Dr. Valentin Fuster

Skeptics are a bit like the grains of sand in an oyster.

FDA approval of CardioMEMS, statins, VT storm, and fish oil and AF are the topics covered by John Mandrola, MD, in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I - Invasive Monitoring for HF - FDA Expands Eligibility for CardioMEMS Heart Failure System https://www.medscape.com/viewarticle/969004 - Haemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial https://doi.org/10.1016/S0140-6736(21)01754-2 - Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: a randomised controlled trial https://doi.org/10.1016/S0140-6736(11)60101-3 II - Statin Use in Primary Prevention - USPSTF Tweaks Primary Prevention Statin Recommendations in New Draft Guidance https://www.medscape.com/viewarticle/968963 - Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Preventive Medication https://www.uspreventiveservicestaskforce.org/uspstf/document/draft-evidence-review/statin-use-primary-prevention-cardiovascular-disease-adults - The Case Against Coronary Artery Calcium Scoring for Cardiovascular Disease Risk Assessment https://www.aafp.org/afp/2019/1215/p734.html III - VT-Storm - Transcutaneous Magnetic Stimulation Promising Against VT Storm https://www.medscape.com/viewarticle/968955 - Effect of Transcutaneous Magnetic Stimulation in Patients With Ventricular Tachycardia Storm https://jamanetwork.com/journals/jamacardiology/fullarticle/2788915 IV - Fish Oil and AF risk - Fish Oil Supplements May Increase the Risk for Atrial Fibrillation: What Does This Mean? https://www.medscape.com/viewarticle/967159 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Being that the majority of VIGOR Training members are middle-aged, and that statins are the second most common prescription for this age group, it's likely that many members may deal with one of the most common side effects of statin use: muscle pain. With this realization in mind, and the fact that many men keep such pain and discomfort to themselves, I felt it was appropriate to share some information on statin induced myopathy (SIM) and related statin side effects. If you experience this side effect, or know someone who does, I hope this article empowers action, so that short-term discomfort doesn't become long-term disability. Statin Use in the United States According to the CDC, as of August, 2019, lipid-lowering drugs ranked second behind antidepressants for prescriptions in adults aged 40-59 in the United States. For adults aged 60-79, they were the most common prescription. Just as there are risks along with benefits for a COVID vaccine, the benefits of statins don't come without risks or side effects either. Known statin side effects include: Muscle myopathies, including pain and weaknessMemory loss or mild dementiaDepressionIncreased risk of tendon rupturesDecreased testosteroneDecreased renal function Being that so many VIGOR Training members are at an age where statins are often prescribed, I'll focus on statins' impacts on muscle function here. Statins and Muscle Myopathies: Pain, weakness, and muscle loss Lipophilic statins, such as simvastatin, atorvastatin, lovastatin, and cerivastatin are more likely to cause SIM. As many as 29% of statin users experience muscle pain or other muscle-related problems. Rhabdomyolysis, an extreme form of myopathy that causes massive muscle loss, affects about 1 in 100,000 statin users. Also, 2-3 out of 100,000 experience immune-mediated necrotizing myopathy, where one's immune system breaks down its own muscle tissue. In one study, where 10.5% of stain users experienced muscle pain, the pain was so severe that 38% couldn't even perform moderate-intensity physical activity and 4% became immobile. Interestingly, exercise seems to exacerbate statin-related muscular problems.  Older adults who use statins tend to lose strength faster and fall more often. Even if a statin-user doesn't experience debilitating side effects, the statins may compromise muscle growth, or even cause muscle loss, which ultimately harms one's health and quality-of-life. Though statins are supposed to improve cardiovascular health, muscle aches, pains, and cramps often keep statin-users from exercising, which reduces or compromises their cardiovascular health. Up to 50% of statin users stop taking them during the first year because of muscle pain. The most common symptoms of statin-related myopathies include cramps, stiffness, and decreased muscular power. Muscle pain can occur in both the upper and lower limbs.  Some research suggests statins change the properties of fast-twitch muscle fibers, which is the muscle type that most affects strength, speed, and power. Clinicians may describe such a patient as having “statin intolerance.” Unlike lactose intolerance, which may cause diarrhea or excessive gas, statin intolerance can lead to serious muscle-related complications. What causes statin induced myopathy? Though doctors prescribe statins to achieve lower cholesterol levels in patients, statins do not lower cholesterol levels. They inhibit cholesterol production, which then affects many physiological needs and processes downstream of that inhibition. I stress that point because few people understand how they work, and what negative impact they may have in comparison to their potential benefit. Fiber lowers cholesterol by removing existing cholesterol. Statins interrupt the production process. That's a big difference, and explains why their use may lead to issues like muscle myopathies. As one paper put it, 

Credits: 0.25 AMA PRA Category 1 Credits™ Claim CME/CE credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-207 Overview: Data are limited regarding statin therapy for primary prevention of atherosclerotic cardiovascular disease in adults 75 years and older. During this episode we will review recent studies on the use of statins in elderly patients and discuss how to consider this data in your clinical practice. Guest: Robert Baldor, MD, FAAFP Music Credit: Richard Onorato

Credits: 0.25 AMA PRA Category 1 Credits™ Claim CME/CE credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-207 Overview: Data are limited regarding statin therapy for primary prevention of atherosclerotic cardiovascular disease in adults 75 years and older. During this episode we will review recent studies on the use of statins in elderly patients and discuss how to consider this data in your clinical practice. Guest: Robert Baldor, MD, FAAFP Music Credit: Richard Onorato

Commentary by Dr. Valentin Fuster

Commentary by Dr. Valentin Fuster

Dr. Susan Shoaf summarizes the article entitled, "A Post Hoc Analysis of Statin Use in Tolvaptan Autosomal Dominant Polycystic Kidney Disease Pivotal Trials," on behalf of her co-authors.

Dr. Susan Shoaf summarizes the article entitled, "A Post Hoc Analysis of Statin Use in Tolvaptan Autosomal Dominant Polycystic Kidney Disease Pivotal Trials," on behalf of her co-authors.

In this podcast, Emily Levitan, ScD, talks about her research that examined the relative strength of associations between region, hospital, and patient characteristics with high-intensity statin use after myocardial infarction. More at: www.consultant360.com/cardiology.

David A. Bluemke, MD, PhD, Editor of Radiology discusses four research articles from the November 2019 issue of Radiology. ARTICLES DISCUSSED – Summary of Opportunities in Interventional and Diagnostic Imaging by Using High-Performance Low-Field-Strength MRI. Radiology 2019; 293:384–393.; Summary of Statin Use and Knee Osteoarthritis Outcome Measures according to the Presence of Heberden Nodes: Results from the Osteoarthritis Initiative. Radiology 2019; 293:396–404.; Summary of Preoperative CT Classification of the Resectability of Pancreatic Cancer: Interobserver Agreement. Radiology 2019; 293:343–349.; Summary of Atrophied Brain T2 Lesion Volume at MRI Is Associated with Disability Progression and Conversion to Secondary Progressive Multiple Sclerosis. Radiology 2019; 293:424–433.;

On this episode of CUBIST, Betsy and Don discuss the article, "Association Between Statin Use and Risk of Dementia After a Concussion." CUBIST is a podcast for health care providers produced by the Defense and Veterans Brain Injury Center. We discuss the latest research on traumatic brain injury (TBI) most relevant to patient care. For more about TBI, including clinical tools, go to dvbic.dcoe.mil or email us at dha.DVBICinfo@mail.mil The views, opinions and/or findings contained in this podcast are those of the host and subject matter experts. They should not be construed as an official Department of Defense position, policy or decision unless so designated by other official documentation. All music in this podcast was used according to Creative Commons licensing. Our theme song is "Dog Wind" by Skill_Borrower, and our credit music is "Esaelp Em Xim" by Pitx, both from CCmixter.org. All music in this podcast was used according to Creative Commons licensing.

Interview with Donald A. Redelmeier, MD, FRCPC, MSHSR, FACP, author of Association Between Statin Use and Risk of Dementia After a Concussion

Interview with Donald A. Redelmeier, MD, FRCPC, MSHSR, FACP, author of Association Between Statin Use and Risk of Dementia After a Concussion

Dr Robert Rosenson, from Mount Sinai - New York, talks to us about statin-related adverse events related to muscles and what you should do if your patient presents with such events.

5 common medications classes which cause nutritional deficiencies include acid reducers, diabetic medications, cholesterol medications diuretic blood pressure medications and birth control pills. Based on my article: https://iherb.co/2knTCQhG Sources: 1. Supplement Your Prescription Copyright 2007 by Hyla Class, MD 2. Drug Muggers by Suzy Cohen, RPh. Copyright 2011, Rodale Publishing. 3. FDA warns PPIs lower Magnesium -https://www.fda.gov/Drugs/DrugSafety/ucm245011.htm 4. Statin Use and 25-Hydroxyvitamin D Blood Level Response to Vitamin D Treatment of Older Adults. Journal American Geriatrics Society. 2017 Jun;65(6):1267-1273. DISCLAIMER: This podcast is not intended to provide a diagnosis, treatment or medical advice. Opinions by Dr. Madrid are for INFORMATIONAL purposes only. Please consult with your physician regarding your situation as each individual situation will vary.

Commentary by Dr. Valentin Fuster

Interview with Douglas K. Owens, MD, MS, USPSTF Task Force member and coauthor of Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: US Preventive Services Task Force Recommendation Statement

C+D spoke to British Heart Foundation medical director Professor Nilesh Samani to discuss why there has been confusion about statin use in recent years. In this C+D clinical podcast you will learn: What statins are and how they work The likelihood of side effects occuring Why statins makes the headlines – for all the wrong reasons What advice pharmacists should give patients concerned about their statin medication.

Commentary by Dr. Valentin Fuster

Commentary by Dr. Valentin Fuster

Wider Statin Use Saves Lives The largest and most reliable study ever to examine the effect of statins has found them to reduce the risk of heart attacks, strokes and premature deaths among a wide range of apparently healthy people. The benefits greatly exceed any known risks associated with taking these drugs.

Dr. Leo Alexandre discusses his manuscript "Statin Use Is Associated With Reduced Risk of Histologic Subtypes of Esophageal Cancer: A Nested Case-Control Analysis."

Dr Alistair Lindsay speaks to Dr Corina Grey, School of Population Health, University of Auckland, about her recent study looking at long-term adherence to statins in ACS patients.Read the full paper: http://goo.gl/KF3NAK

Colin Baigent, Professor of Epidemiology, Clinical Trial Service Unit, Oxford, talks about why the drug Statin saves lives.

Colin Baigent, Professor of Epidemiology, Clinical Trial Service Unit, Oxford, talks about why the drug Statin saves lives.