Podcasts about Parkinsonism

There are so many ways to get involved with Parkinson's disease, from community building to advocacy, research participation to fundraising. Taking that first step toward involvement can be daunting, but many people say it's a critical part of living well with the disease. In this episode of The Michael J. Fox Foundation Parkinson's Podcast, members of the Foundation's Patient Council share stories of their own first steps, explore how engagement has impacted their journeys and offer advice and perspective to others who are looking for ways to make meaningful change. Tune in to hear guest hosts Jimmy Choi, diagnosed with Parkinson's in 2003, and Hadley Ferguson, diagnosed with multiple system atrophy (MSA-P), an atypical Parkinsonism in 2014, reflect on those stories, recorded live in the MJFF offices. Learn more about the many ways to get involved today at michaeljfox.org. Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 The Foundation's landmark study, the Parkinson's Progression Marker's Initiative, also known as PPMI, is recruiting volunteers. Join the study that's changing everything at michaeljfox.org/podcast-ppmi. Mentioned in this episode:The Foundation's landmark research study is exploring the connection between sense of smell and brain disease. People with and without Parkinson's can help by taking a free scratch-and-sniff test. Get yours at mysmelltest.org/request.

Modern medicine has made significant strides in managing chronic diseases, yet many elderly patients with multiple conditions continue to deteriorate under standard care. Conventional therapies often overlook the root causes of chronic degeneration, such as oxidative stress, mitochondrial dysfunction, toxin accumulation, and nutritional deficiencies. IntegrativeOrthomolecular Medicine (IOM) offers a solution-oriented framework that emphasizes restoring biochemical balance through therapeutic nutrition, detoxification, metabolic support, and lifestyle interventions. This case study illustrates the practical application and impressive results of an IOM protocol in an elderly woman with T2DM, CKD with renal insufficiency, Parkinsonism, and recurrent infections.In this episode George discusses the case study of a 94 year old woman who made significant improvements using Orthromolecular nutrition. www.georgebatista.com

Could nicotine—yes, the same compound found in cigarettes—actually help people with Parkinson's Disease?

Can Lion's Mane mushroom help with Parkinson's disease? Research suggests it may support nerve growth, reduce inflammation, and protect dopamine-producing neurons, potentially improving cognitive function and slowing neurodegeneration. Some studies show benefits in Parkinson's models, while human trials highlight its role in memory, focus, and brain health.

Dopamine is essential for movement, mood, and motivation—but did you know that too much dopamine inside of dopamine producing cells can be toxic to those cells? In this episode, we explore dopamine toxicity and its implications for those living with Parkinson's Disease. **The video version contains visuals that could be even more helpful and will enhace your experence of this episode!** We'll cover:

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika VijayIn this episode, I will be discussing Dopamine Introductory details like History, Synthesis, Metabolism and Re uptake, etc I will be talking about all these and additionally, I will also talk about Parkinsonism Disease and some drugs used in this pathology.My podcast is featured in "BEST SCIENCE PODCASTS"- Check the link here:https://podcasts.feedspot.com/india_science_podcasts/My podcast is featured in "BEST INDIAN MEDICAL PODCASTS". Check the link here:https://podcasts.feedspot.com/india_medical_podcasts/?feedid=5503395For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine."Pharmacology Further" E-Newsletter and Podcast:The links for these are at all my websites and specifically:Link for E-Newsletter: https://pharmacologyfurther.substack.com/Link for the E-Newsletter Podcast: https://www.pharmacologyfurther.comIt actually contains lot of updates about the medical sciences, drug information and my podcast updates also.You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!Please leave Review on Apple podcasts!My E-Newsletter sign up at Substack!Connect on Twitter & Instagram!My books on Amazon & Goodreads!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika VijayIn this episode, I will be discussing Dopamine Introductory details like History, Synthesis, Metabolism and Re uptake, etc I will be talking about all these and additionally, I will also talk about Parkinsonism Disease and some drugs used in this pathology.My podcast is featured in "BEST SCIENCE PODCASTS"- Check the link here:https://podcasts.feedspot.com/india_science_podcasts/My podcast is featured in "BEST INDIAN MEDICAL PODCASTS". Check the link here:https://podcasts.feedspot.com/india_medical_podcasts/?feedid=5503395For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine."Pharmacology Further" E-Newsletter and Podcast:The links for these are at all my websites and specifically:Link for E-Newsletter: https://pharmacologyfurther.substack.com/Link for the E-Newsletter Podcast: https://www.pharmacologyfurther.comIt actually contains lot of updates about the medical sciences, drug information and my podcast updates also.You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!Please leave Review on Apple podcasts!My E-Newsletter sign up at Substack!Connect on Twitter & Instagram!My books on Amazon & Goodreads!

Could a simple drug intended to treat cancer treatment complications be the next big breakthrough in Parkinson's Disease treatment? Dr. Jonathan Sackner-Bernstein, MD, is leading research on tyrosine hydroxylase inhibition as a novel approach to managing Parkinson's symptoms and slowing disease progression. Unlike traditional treatments that focus solely on replacing lost dopamine, a previously FDA approved drug (RB-190) targets tyrosine hydroxylase (TH)—the enzyme responsible for dopamine production—offering a new way to reduce dyskinesias, oxidative stress, and dopamine imbalances in the brain. Watch on YouTube In this episode, we'll break down:  ✅ What tyrosine hydroxylase does and its role in dopamine production ✅ Why too much dopamine in certain brain regions can be problematic ✅ How RB-190 could change the way we treat Parkinson's Disease ✅ The groundbreaking work of Dr. Sackner-Bernstein and what it means for the future If you or a loved one is affected by Parkinson's, this research could be a game-changer! Stay informed about the latest treatments and breakthroughs by liking, subscribing, and turning on notifications. You all will be the FIRST to know when phase IIA of the drug trials start and participants are needed. Follow Dr. Bernstein's blog here: https://www.parkinsonsdisease.blog/

In this exclusive interview, I was honored to sit down with Dr. Jonathan Sackner-Bernstein to discuss his groundbreaking work in the treatment of Parkinson's Disease. (View on YouTube here) As a leading expert and innovator, Dr. Sackner-Bernstein shares insights into the challenges of current therapies, exciting advancements in research, and the potential for transformative treatments that could improve the lives of millions. Do NOT miss this, as he is going to discuss some very exciting news regarding current research for the first time in this interview. Topics covered include: -The limitations of current Parkinson's therapies and the need for innovation. -New approaches being developed to address both motor and non-motor symptoms. -How emerging science is shaping the future of Parkinson's care. This is a must-watch for anyone affected by Parkinson's Disease or interested in the cutting-edge science behind its treatment. Don't forget to like, share, and subscribe for more expert content on Parkinson's Disease and wellness! Follow Dr Bernstein with his blog and sign up for regular updates: https://www.parkinsonsdisease.blog Help to support this channel and out efforts to educate the world about Parkinson's Disease and get access to personalized content: https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join  https://www.patreon.com/pdeducation Please be sure to give support to our channel sponsors: Comfort Linen: https://comfortlinen.com/PARKINSONSDISEASEEDUCATION (15% off entire order when applying the code PARKINSONSDISEASEEDUCATION at checkout) Kizik Shoes: https://kizik.sjv.io/pdeducation Cure Hydration: https://lvnta.com/lv_XG06Rho8SSlXEq3qlV If you have products that you would like for me to review on the channel please send them here: Parkinson's Disease Education P.O. Box 1678 Broken Arrow, OK 74013 Medical Disclaimer All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #dopamine #medication #research #interview

Could light therapy be a breakthrough for Parkinson's Disease? In this episode (watch on YouTube here), we dive into the science behind Photobiomodulation (PBM) and how it may help manage Parkinson's symptoms. PBM uses red and near-infrared light to stimulate cellular activity, potentially offering benefits such as: ✅ Neuroprotection & Mitochondrial Support – Improves brain cell energy production and reduces oxidative stress.  ✅ Dopamine Preservation – May protect dopamine-producing neurons and slow disease progression.  ✅ Reduced Inflammation – Helps combat neuroinflammation linked to Parkinson's symptoms. ✅ Motor Function Improvement – Could enhance movement, coordination, and balance. ✅ Cognitive & Mood Benefits – May support brain plasticity, mood regulation, and sleep. While early research is promising, more studies are needed to confirm PBM's long-term impact. Could this be the future of Parkinson's treatment? You can find information about LifeWave products here: https://lifewave.com/hylandpt To book a call with me to ask questions or talk about LifeWave use this link: https://calendly.com/pdeducation/lifewave-consultation  Test your knowledge about Parkinson's Disease! Take our free quiz here: https://www.tryinteract.com/share/quiz/66eadc2571c20e90c568e1e1 Help to support this channel and out efforts to educate the world about Parkinson's Disease and get access to personalized content: https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join  https://www.patreon.com/pdeducation  Please be sure to give support to our channel sponsors: Comfort Linen: https://comfortlinen.com/PARKINSONSDISEASEEDUCATION(15% off entire order when applying the code PARKINSONSDISEASEEDUCATION at checkout) Kizik Shoes: https://kizik.sjv.io/pdeducation Cure Hydration: https://lvnta.com/lv_XG06Rho8SSlXEq3qlV If you have products that you would like for me to review on the channel please send them here: Parkinson's Disease Education P.O. Box 1678 Broken Arrow, OK 74013 Medical Disclaimer All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #photobiomodulation #redlighttherapybenefits #mitochondrialhealth #peptides #lifewave

Dan Loges delivers the latest entertainment news on: - Patti Smith collapses at live performance and cuts show short. - The Eagle's guitarist Steuart Smith forced into retirement by Parkinsonism diagnosis. - Pete Davidson shows off tattoo removal.

Join us for another Neurofeedback Podcast episode featuring Jay Gunkelman, QEEGD (the man who has read over 500,000 brain scans) and Dr. Mari Swingle (author of i-Minds). Hosted by Pete Jansons, this episode explores operant vs. classical conditioning, the psychology of rewards vs. punishments, and how neurofeedback shapes behavior.

How do doctors diagnose Parkinson's Disease? In this episode (video here), we break down the key tests and evaluations used to identify Parkinson's, including: Clinical Evaluation: A neurologist assesses motor symptoms like tremors, rigidity, and slowness of movement, alongside your medical history. DaTscan: An imaging test that uses a radioactive tracer to visualize dopamine-producing cells in the brain, helping distinguish Parkinson's from other movement disorders. Alpha-Synuclein Tests: Cutting-edge biomarker tests, including spinal fluid analysis and skin biopsies, that detect misfolded alpha-synuclein—a hallmark of Parkinson's. While no single test can confirm Parkinson's, these tools, combined with a doctor's expertise, provide critical insights for diagnosis. Don't forget to like, share, and subscribe for more expert content on Parkinson's Disease research and management! Help to support this channel and out efforts to educate the world about Parkinson's Disease and get access to personalized content: https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join  https://www.patreon.com/pdeducation  Please be sure to give support to our channel sponsors: Comfort Linen: https://comfortlinen.com/PARKINSONSDISEASEEDUCATION (15% off entire order when applying the code PARKINSONSDISEASEEDUCATION at checkout) Kizik Shoes: https://kizik.sjv.io/pdeducation Cure Hydration: https://lvnta.com/lv_XG06Rho8SSlXEq3qlV  If you have products that you would like for me to review on the channel please send them here: Parkinson's Disease Education P.O. Box 1678 Broken Arrow, OK 74013 Medical Disclaimer All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use

What causes dyskinesia in Parkinson's Disease, and why does it often appear as a side effect of treatment? In this video, we explore the science behind Parkinson's dyskinesia—a condition characterized by involuntary, erratic movements that can significantly impact quality of life. We'll break down: -How long-term use of levodopa (a common Parkinson's medication) can lead to dyskinesia. -The role of dopamine fluctuations and brain receptor changes in causing these movements. -Insights into other contributing factors and strategies for managing dyskinesia effectively. Whether you're living with Parkinson's or supporting someone who is, this video offers a deeper understanding of this challenging symptom and what can be done to address it. Join me in a FREE webinar 5 Top Parkinson's Myths and How to Debunk Them on Jan 8th, Jan 15th, and Jan 17th. Here is the link to register: https://pdeducation.podia.com/webinars Help to support this channel and out efforts to educate the world about Parkinson's Disease and get access to personalized content: https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join  https://www.patreon.com/pdeducation Please be sure to give support to our channel sponsors: Comfort Linen: https://comfortlinen.com/PARKINSONSDISEASEEDUCATION(15% off entire order when applying the code PARKINSONSDISEASEEDUCATION at checkout) Kizik Shoes: https://kizik.sjv.io/pdeducation Cure Hydration: https://lvnta.com/lv_XG06Rho8SSlXEq3qlV If you have products that you would like for me to review on the channel please send them here: Parkinson's Disease Education P.O. Box 1678 Broken Arrow, OK 74013 Medical Disclaimer All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #dyskinesia #dopamine

Did you know that rhinorrhea (runny nose) could be linked to Parkinson's Disease? In this episode (video version here), we uncover the relationship between these seemingly unrelated conditions. Learn why rhinorrhea might occur in Parkinson's patients, how it differs from typical causes like allergies or colds, and what it could reveal about underlying disease mechanisms.  Key topics include:  -What causes rhinorrhea in Parkinson's Disease?  -How autonomic dysfunction and dopamine loss contribute to this symptom.  -Effective strategies for managing rhinorrhea in Parkinson's.  Join us as we explore this unique symptom and its implications for understanding Parkinson's. Don't forget to like, share, and subscribe for more expert insights on Parkinson's Disease and its management.  Test your knowledge about Parkinson's Disease! Take our free quiz here: https://www.tryinteract.com/share/quiz/66eadc2571c20e90c568e1e1 Help to support this channel and out efforts to educate the world about Parkinson's Disease and get access to personalized content: https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join  https://www.patreon.com/pdeducation Please be sure to give support to our channel sponsors:  Comfort Linen: https://comfortlinen.com/PARKINSONSDISEASEEDUCATION (15% off entire order when applying the code PARKINSONSDISEASEEDUCATION at checkout)  Kizik Shoes: https://kizik.sjv.io/pdeducation Cure Hydration: https://lvnta.com/lv_XG06Rho8SSlXEq3qlV If you have products that you would like for me to review on the channel please send them here: Parkinson's Disease Education P.O. Box 1678 Broken Arrow, OK 74013  Medical Disclaimer: All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider.  Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #runnynose

In this episode of Discovery Matters we delve into groundbreaking advancements in Parkinson's disease research. Dodi and Conor transport us to the frontier of medical innovation, exploring the latest discoveries and techniques that hold promise for early diagnosis and treatment of Parkinson's disease. Show notes • Decet, Marianna et al. ‘A candidate loss-of-function variant in SGIP1 causes synaptic dysfunction and recessive parkinsonism', Cell Reports Medicine, Volume 5, Issue 10. • Hällqvist, J., Bartl, M., Dakna, M. et al. ‘Plasma proteomics identify biomarkers predicting Parkinson's disease up to 7 years before symptom onset'. Nat Commun 15, 4759 (2024). • Roald Dahl's Marvellous Children's Charity Keywords: non-invasive procedure, early diagnosis, synaptic homeostasis, Parkinsonism, biomarkers, machine learning, REM sleep disorder, inflammatory pathways, dopaminergic cells, predictive diagnostics, early intervention.

Exercise is crucial for managing Parkinson's Disease, but what if you're battling fatigue? In this video, we dive into strategies to stay active without overexerting yourself. Learn how to tailor your exercise routine to improve strength, balance, and mobility while managing your energy effectively. Video version is here. Key topics include: -Why fatigue happens in Parkinson's and how exercise can help. -The best types of low-impact exercises for maintaining energy levels. -Tips for pacing, recovery, and avoiding burnout during workouts. Find out how to build a sustainable fitness plan that works for you and supports your fight against Parkinson's symptoms. Subscribe for more expert advice on living well with Parkinson's Disease.  Help to support this channel and out efforts to educate the world about Parkinson's Disease and get access to personalized content:  https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join https://www.patreon.com/pdeducation Please be sure to give support to our channel sponsors:  Comfort Linen: https://comfortlinen.com/PARKINSONSDISEASEEDUCATION (15% off entire order when applying the code PARKINSONSDISEASEEDUCATION at checkout)  Kizik Shoes: https://kizik.sjv.io/q4y1RL Cure Hydration: https://lvnta.com/lv_XG06Rho8SSlXEq3qlV If you have products that you would like for me to review on the channel please send them here: Parkinson's Disease Education P.O. Box 1678 Broken Arrow, OK 74013  Medical Disclaimer All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider.  Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #exercise #fatigue #parkinsonsexercise

Do all people with Parkinson's disease get dementia? And what exactly is the difference between Parkinson's disease and Parkinson's disease dementia?

Dr. Lisa Blacklock, nuclear radiologist, discusses 123I-Ioflupane imaging in diagnosing Parkinsonian syndromes. Lisa covers its role in improving diagnostic accuracy, differentiating Parkinson's disease, and common interpretation pitfalls. Tune in for key insights on this valuable imaging tool. Practical Overview of 123I-Ioflupane Imaging in Parkinsonian Syndromes. Mercer et al. RadioGraphics 2024; 44(2):e230133. 

Dr. Rick Helmich tells us about the role of functional MRI in understanding the circuits of tremor. The conversation starts with a description of his most famous theory on the pathophysiology of Parkinsonism tremor ('dimmer-switch' hypothesis) and moves towards other forms of tremors, such as dystonic, Holmes and essential and even physiological tremor.

Discover why exercise is more than just physical activity—it's a powerful treatment for Parkinson's Disease. In this episode (video here!), we break down the science behind how regular, targeted exercise can help improve motor symptoms, balance, and overall quality of life for those living with Parkinson's. Learn about the types of exercises shown to be most effective, from aerobic workouts to strength training and balance exercises. Key points covered: -The neuroprotective effects of exercise and how it boosts brain health.  -How exercise can enhance dopamine production and improve movement. -Tips for creating a sustainable and effective exercise plan tailored to Parkinson's needs. Whether you're newly diagnosed or have been living with Parkinson's for years, this episode will provide you with practical insights to harness the full potential of exercise as medicine. Don't forget to like, subscribe, and share for more expert content on Parkinson's treatment and wellness. Help to support this channel and out efforts to educate the world about Parkinson's Disease and get access to personalized content: https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join https://www.patreon.com/pdeducation Please be sure to give support to our channel sponsors:  Comfort Linen: https://comfortlinen.com/PARKINSONSDISEASEEDUCATION (15% off entire order when applying the code PARKINSONSDISEASEEDUCATION at checkout)  Kizik Shoes: https://kizik.sjv.io/q4y1RL Cure Hydration: https://lvnta.com/lv_XG06Rho8SSlXEq3qlV If you have products that you would like for me to review on the channel please send them here: Parkinson's Disease Education P.O. Box 1678 Broken Arrow, OK 74013  Medical Disclaimer All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider.  Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #exercise #parkinsonsexercise

Did you know that stress can play a significant role in worsening Parkinson's Disease symptoms? Furthermore, have you ever considered WHY this can happen? In this episode, we explore the surprising connection between stress and Parkinson's, breaking down how stress affects both motor and non-motor symptoms like tremors, stiffness, anxiety, and sleep disturbances. You'll also learn practical tips and strategies to manage stress effectively and improve your overall well-being. Hint: It is simpler than you may think. Whether you're newly diagnosed or have been living with Parkinson's for years, understanding the impact of stress can be a game-changer in managing your symptoms. If you find this video helpful, don't forget to like, subscribe, and share it with others who may benefit! FitBit fitness trackers can help you to practice mindfulness techniques and also have exercises that can prepare you for sleep at night. This is an Amazon link to the FitBit that I currently wear when awake or asleep: https://amzn.to/3AiTsaQ Join our free group on Facebook and be a part of a community: https://www.facebook.com/groups/pdeducation Help to support this channel and out efforts to educate the world about Parkinson's Disease and get access to personalized content: https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join  https://www.patreon.com/pdeducation Please be sure to give support to our channel sponsors: Comfort Linen: https://comfortlinen.com/PARKINSONSDISEASEEDUCATION(15% off entire order when applying the code PARKINSONSDISEASEEDUCATION at checkout) Kizik Shoes: https://kizik.sjv.io/q4y1RL Orthofeet: https://lvnta.com/lv_0Pn1TAIM5VDdOHxlYG If you have products that you would like for me to review on the channel please send them here: Parkinson's Disease Education P.O. Box 1678 Broken Arrow, OK 74013 Medical Disclaimer All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #supplements #stress #stressmanagement #insomnia #sleepdisorder

Dr. Gordon Smith and Dr. Whitley Aamodt discuss end-of-life care for patients with neurodegenerative diseases, focusing on healthcare utilization, hospice enrollment, and the importance of early conversations about care preferences. Show reference: https://www.neurology.org/doi/10.1212/WNL.0000000000209925    

Dr. Gordon Smith talks with Dr. Whitley Aamodt about the comparison of resource utilization between US Medicare decedents with neurodegenerative diseases and those with cancer. Read the related article in Neurology. Disclosures can be found at Neurology.org.

In this episode, (view on YouTube) we explore the link between magnesium and its potential to improve sleep disorders in people with Parkinson's Disease. Magnesium plays a key role in nerve function and muscle relaxation, which may help address common Parkinson's sleep issues like insomnia, restless legs syndrome (RLS), and REM sleep behavior disorder (RBD). We'll dive into how magnesium supports melatonin production and its calming effects on the nervous system. You will discover: -How magnesium impacts sleep quality and helps with symptoms like insomnia and RLS. -The potential benefits of magnesium supplementation for Parkinson's patients. -The role of magnesium in producing melatonin and regulating the sleep-wake cycle. -Learn how this vital mineral could offer symptom relief and support better rest for those living with Parkinson's. Don't forget to like and subscribe for more updates on Parkinson's Disease research and treatments! BEFORE YOU TRY: Always consult a healthcare provider before starting any new supplements or treatments. That said, here are some possibilities found on Amazon for supplementing: -Magnesium Glycinate: https://amzn.to/3A8qWIS -Magnesium L-Theanine (plus Mag Citrate for bowel regularity): https://lvnta.com/lv_1j2lt1JE3o8JvJD4Sx -Magnesium L-Threonate: https://amzn.to/3U9XitQ Join our free group on Facebook and be a part of a community: https://www.facebook.com/groups/pdeducation Help to support this channel and out efforts to educate the world about Parkinson's Disease and get access to personalized content:  https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join  https://www.patreon.com/pdeducation  Please be sure to give support to our channel sponsors: Comfort Linen: https://comfortlinen.com/PARKINSONSDISEASEEDUCATION (15% off entire order when applying the code PARKINSONSDISEASEEDUCATION at checkout) Kizik Shoes: https://kizik.sjv.io/q4y1RL  Orthofeet: https://lvnta.com/lv_0Pn1TAIM5VDdOHxlYG If you have products that you would like for me to review on the channel please send them here: Parkinson's Disease Education P.O. Box 1678 Broken Arrow, OK 74013 Medical Disclaimer All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #supplements #magnesium #magnesiumdeficiency #insomnia #sleepdisorder #restlesslegsyndrome #remsleepbehaviordisorder #melatonin

In the October 2024 replay features four episodes on approaches to clinical diagnosis of parkinsonism. The episode starts off with Dr. Colin Hoy discuss the concept of prodromal Parkinson disease and the ethical considerations surrounding its diagnosis. The episode leads into a conversation with Dr. Chris Gibbons discussing skin biopsies to detect phosphorylated α-synuclein. In the third episode Drs. Michiko K. Bruno and Lawrence Golbe about a practical diagnostic algorithm for atypical parkinsonian disorders Drs. Michiko K. Bruno and Lawrence Golbe discuss a practical diagnostic algorithm for atypical parkinsonian disorders. The episode concludes with Dr. Eduardo De Pablo-Fernández talking about the strengths of DAT imaging in diagnosing patients with Parkinsonian disorders. Previous Podcasts: The Ethical Landscape of Prodromal Parkinson Disease Skin Biopsy Detection of Phosphorylated α-Synuclein General Neurologist's Practical Diagnostic Algorithm for Atypical Parkinsonian Disorders Interpreting DAT Imaging Results in the Clinical Context Article Links: The Ethical Landscape of Prodromal Parkinson Disease  Skin Biopsy Detection of Phosphorylated α-Synuclein in Patients With Synucleinopathies A General Neurologist's Practical Diagnostic Algorithm for Atypical Parkinsonian Disorders  Neuropathologic Validation and Diagnostic Accuracy of Presynaptic Dopaminergic Imaging in the Diagnosis of Parkinsonism Disclosures can be found at Neurology.org.

Did you know that your gut health could be linked to Parkinson's Disease? Recent research has uncovered a fascinating connection between the gut microbiome and the development of Parkinson's. In this episode, we explore how changes in gut bacteria may contribute to brain inflammation, the misfolding of alpha-synuclein proteins, and the progression of Parkinson's Disease symptoms. Scientists are investigating potential treatments targeting the gut-brain axis, including probiotics and fecal transplants, to restore gut health and slow the progression of Parkinson's.  Watch (YouTube version) and listen to learn more about this groundbreaking research and how it could shape the future of Parkinson's treatments.  You might consider searching on Amazon for OTC probiotics such as this one from Nutricost: https://amzn.to/3zEwUkG Join our free group on Facebook and be a part of a community: https://www.facebook.com/groups/pdeducation Help to support this channel and out efforts to educate the world about Parkinson's Disease and get access to personalized content:  https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join  https://www.patreon.com/pdeducation Please be sure to give support to our channel sponsors: Comfort Linen*: https://comfortlinen.com/PARKINSONSDISEASEEDUCATION *(15% off entire order when applying the code PARKINSONSDISEASEEDUCATION at checkout) Kizik Shoes: https://kizik.sjv.io/q4y1RL Orthofeet: https://lvnta.com/lv_0Pn1TAIM5VDdOHxlYG If you have products that you would like for me to review on the channel please send them here: Parkinson's Disease Education  P.O. Box 1678 Broken Arrow, OK 74013 Medical Disclaimer All information, content, and material of this program is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #microbiome #probiotics #prebiotics #supplements #guthealth

Video version of the podcast is here. This may not be a "hot take" with regards to supplements, but we will be talking about some cool beans. Mucuna pruriens, also known as the velvet bean, is a natural source of levodopa, a key treatment for Parkinson's Disease (PD). Research shows it may reduce PD symptoms and have a quicker onset and longer duration than standard medications like carbidopa/levodopa (C/L). However, it can cause more side effects, particularly with prolonged use. Unlike C/L, Mucuna lacks carbidopa, which helps reduce side effects. While it has potential benefits, dosage standardization is a concern, and more research is needed. Always consult a doctor before using it. If you want to try for yourself this is one possibility from Nutricost via Amazon and is highly rated: https://amzn.to/3ZqSyn6  This is the link to Dr. Zayas' full video on Mucuna: https://youtu.be/rY1ycuJgSII?si=hAUXwcrqqEuP3qti Help to support this podcast and our efforts to educate the world about Parkinson's Disease and get access to personalized content:  https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join  https://www.patreon.com/pdeducation Please be sure to give support to our channel sponsors:  Comfort Linen: https://comfortlinen.com/PARKINSONSDISEASEEDUCATION (15% off entire order when applying the code PARKINSONSDISEASEEDUCATION at checkout)  Kizik Shoes: https://kizik.sjv.io/q4y1RL Orthofeet: https://lvnta.com/lv_0Pn1TAIM5VDdOHxlYG If you have products that you would like for me to review on the channel please send them here: Parkinson's Disease Education P.O. Box 1678 Broken Arrow, OK 74013  Medical Disclaimer All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use. #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #mucuna #homeopathy #supplements #levodopa #dopamine

Kennedy Dunn, 3rd year medical student at Howard U and Dr. Bianca Campbell, PharmD and 3rd medical student at Howard U discuss Passion, Patience and what it means to be human in the 3rd episode of Stranger Fruit Vol II.   Timestamps: 0:00 The Intersection of Passion and Patient Care in Medicine 8:10 Patient-Centric Perspectives & Self-Care for Healthcare Providers 15:56 Navigating Career Passion, Patience, and Opportunities 26:16 Challenges and Growth in Medical Careers and Personal Well-being 40:42 Embracing Individuality and Professional Identity in Health Fields   References:  Bush G, Luu P, Posner MI. Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci. 2000 Jun;4(6):215-222. doi: 10.1016/s1364-6613(00)01483-2. PMID: 10827444. Casey, B. J., Giedd, J. N., & Thomas, K. M. (2000). "Structural and functional brain development and its relation to cognitive development." Biological Psychology, 54(1-3), 241-257. Delgado, M. R., Nearing, K. I., LeDoux, J. E., & Phelps, E. A. (2008). "Neural circuits for affective learning and memory: The amygdala and beyond." Current Opinion in Neurobiology, 18(2), 161-170. DiMatteo MR, Sherbourne CD, Hays RD, Ordway L, Kravitz RL, McGlynn EA, Kaplan S, Rogers WH. Physicians' characteristics influence patients' adherence to medical treatment: results from the Medical Outcomes Study. Health Psychol. 1993 Mar;12(2):93-102. doi: 10.1037/0278-6133.12.2.93. PMID: 8500445. Frank, M. J., Seeberger, L. C., & O'Reilly, R. C. (2004). "By carrot or by stick: Cognitive reinforcement learning in Parkinsonism." Science, 306(5703), 1940-1943. Stewart MA. Effective physician-patient communication and health outcomes: a review. CMAJ. 1995 May 1;152(9):1423-33. PMID: 7728691; PMCID: PMC1337906. Street RL Jr, Makoul G, Arora NK, Epstein RM. How does communication heal? Pathways linking clinician-patient communication to health outcomes. Patient Educ Couns. 2009 Mar;74(3):295-301. doi: 10.1016/j.pec.2008.11.015. Epub 2009 Jan 15. PMID: 19150199. Suchman AL, Markakis K, Beckman HB, Frankel R. A model of empathic communication in the medical interview. JAMA. 1997 Feb 26;277(8):678-82. PMID: 9039890. Intro Music: Bosch's Garden - by Kjartan Abel. This work is licensed under the following: CC BY-SA 4.0 Attribution-ShareAlike 4.0 International.

Explore how high-dose thiamine (vitamin B1) could help alleviate some Parkinson's Disease symptoms. Thiamine is crucial for nerve function and brain energy production, and recent studies suggest that higher doses might improve motor symptoms like tremors and stiffness. Could this vitamin offer a new approach to managing Parkinson's? Watch to learn more (video premieres here Saturday August 31, 2024)! Parkinson's and the B1 Therapy book by Dr. Daphne Bryan, PhD: https://amzn.to/4cQVFrk Help to support this channel and out efforts to educate the world about Parkinson's Disease and get access to personalized content:  https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join  https://www.patreon.com/pdeducation Please be sure to give support to our channel sponsors: Comfort Linen: https://comfortlinen.com/PARKINSONSDISEASEEDUCATION (15% off entire order when applying the code PARKINSONSDISEASEEDUCATION at checkout) Kizik Shoes: https://kizik.sjv.io/q4y1RL Orthofeet: https://lvnta.com/lv_0Pn1TAIM5VDdOHxlYG If you have products that you would like for me to review on the channel please send them here: Parkinson's Disease Education P.O. Box 1678 Broken Arrow, OK 74013 Medical Disclaimer: All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #b1 #thiamine #supplements

Autoimmune cerebellar ataxia and other autoimmune movement disorders encompass a broad spectrum of different clinical syndromes, antibodies, and immunopathophysiologic mechanisms. Given the overlap between phenotypes and antibodies, panel testing in serum and CSF is recommended. In this episode, Gordon Smith, MD, FAAN, speaks with Bettina Balint, MD, author of the article “Autoimmune Movement Disorders,” in the Continuum August 2024 Autoimmune Neurology issue. Dr. Smith is a Continuum® Audio interviewer and professor and chair of neurology at Kenneth and Dianne Wright Distinguished Chair in Clinical and Translational Research at Virginia Commonwealth University in Richmond, Virginia. Dr. Balint is an assistant professor for clinical research on complex movement disorders and Parkinson's diseases, a consultant neurologist, the head of the Department of Movement Disorders, and co-lead for the Centre for Movement Disorders and Functional Neurosurgery in the Department of Neurology at the University Hospital Zurich in Zurich, Switzerland. Additional Resources Read the article: Autoimmune Movement Disorders Subscribe to Continuum: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @gordonsmithMD Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum, the premier topic-based neurology clinical review and CME journal from the American Academy of Neurology. Thank you for joining us on Continuum Audio, which features conversations with Continuum's guest editors and authors who are the leading experts in their fields. Subscribers to the Continuum journal can read the full article or listen to verbatim recordings of the article and have access to exclusive interviews not featured on the podcast. Please visit the link in the episode notes for more information on the article, subscribing to the journal, and how to get CME.   Dr Smith: This is Dr Gordon Smith. Today, I'm interviewing Dr Bettina Balint about her article on ataxia and other autoimmune movement disorders, which appears in the August 2024 Continuum issue on autoimmune neurology, which is a highly anticipated and exciting issue. Dr Balint, welcome to the podcast, and, perhaps, you can just introduce yourself to our audience and tell us a little bit about your practice and how you became interested in this topic.   Dr Balint: Thank you, Gordon, for having me. I am an assistant professor for clinical research in complex movement disorders and Parkinson's disease at the University of Zurich and the Head of the Movement Disorders Department at the University Hospital in Zurich. So while I'm originally German (from Heidelberg), I have now been to Switzerland since end of 2021.   Dr Smith: So, you know, how many movement disorder chiefs have a focus on autoimmune movement disorders? I found that really interesting. Most of the movement disorder folks I interact with, their primary interest is in neurodegeneration.   Dr Balint: Very good question. Even so, I never asked myself that question, really, but I think I'm the only one with this designated focus as such. Many people come from the neurology angle - most of them. Even so, movement-disorder people really welcome this field and are interested, but I think somebody who has dedicated their interest and time to it? I think I can't actually think of many other people.   Dr Smith: Yeah, I think it's really cool, and, of course, autoimmune neurology is the flavor of the day these days, right? I mean, I remember when I was at the University of Utah, we were recruiting Stacy Clardy (who I think many of our listeners will know). I remember thinking, you know, she's never going to be busy. How many of these autoimmune problems are there, really? And she was, like, deluged when she came. These are really common problems. I guess that was one question I had for you. You know, we think of these as rare disorders, and when we look at the article, you have these tables of these antibodies, and a lot of them are pretty uncommon – but, cumulatively, how common are autoimmune movement disorders?   Dr Balint: It's a very difficult question, because we don't have good epidemiological data. And if you look at series, I mean, most papers addressing this issue come actually from the ataxia field. And then, depending on where you look at, you might find varying numbers, and they might be also influenced by the fact that they come from ataxia centers with own certain biases. Even so, it's very close to my heart, but, I also still think it's overall very rare. So, in my practice, I see all sorts of movement disorders, and overall, they're still quite rare, but the point is that they are treatable and have important management implications, so you want to be sure not to miss any of them.   Dr Smith: Well, maybe we can go to that next. Part of the challenge here, of course, is there's just so many of these different syndromes and antibodies. Are there pearls that you can provide our listeners that would help them guide when they should be thinking about these disorders when they confront a patient with a particular phenotype? Like ataxia, for instance - you know, there are certain aspects of the clinical scenario that should trigger, “Wow, this might be an autoimmune problem”.   Dr Balint: So, in general, I would say there are certain scenarios where you would want to think of an autoimmune etiology in your differential. One is a very characteristic phenotype. So, speaking broadly in terms of movement disorders, stiff-person spectrum disorders have a very characteristic phenotype which you need to recognize, and then you will be able to see it when a patient enters. Important phenotypes to know which are very characteristic are faciobrachial dystonic seizures, for example, with anti-GA1 antibodies, or pseudofinalistic movements in non-REM sleep is IgLON5 antibodies, leg myoclonus is CASPR2 antibodies. I don't want to necessarily enumerate all the scenarios. The point here is there are some characteristic phenotypes where you would think of autoimmune neurology. Another scenario where you would think of autoimmune, for example, the context of late-onset paroxysmal movement disorders. So, classically, when we think of paroxysmal dyskinesia, we think of a group of genetic disorders, but if somebody develops a paroxysmal movement disorder later in life in adulthood, then you would think of autoimmune neurology, and this applies also in the context of episodic ataxias. Another red flag might be a propensity to autoimmunity. For example, somebody with type one diabetes and vitiligo coming in for cerebellar ataxia, of course, you would think of anti-GAD ataxia. And, similarly, if somebody has recently been diagnosed with a cancer and develops a rapidly disabling syndrome, of course, then you would think of a paraneoplastic autoimmune disorder. And with autoimmune syndrome, there are some symptoms which are also like tell-tale signs. So, for example, somebody with a stiff-person spectrum disorder, an ataxia with long-lasting diarrhea over months, losing weight - investigations haven't found anything, then you would think of DPPX antibodies or celiac disease. Or, if you have, like, a neuropathic pain which is otherwise not explained, then you might think of CASPR2 antibodies in somebody with a cerebellar ataxia. So, there are some features of some antibodies. (Again, I will not now list all of them which might point you to a diagnosis.) Then, of course, another scenario which is important, I think, is if you have a hemisyndrome without a structural lesion on imaging. Classically, neurologists are trained to think of a hemisyndrome - we look for a lesion on the contralateral side. But if you have, like, for example, a hemichorea without a lesion or a hemiataxia without a lesion, one should also think of an autoimmune disorder with antibodies. And then, more generally, of course, if you have changes on brain MRI or information on CSF, of course, if the clinical cause is more rapidly progressive - and last, but not least, if somebody does not really fit into our categories of the degenerative symptoms or metabolic syndromes or functionality disorders, then, of course, one should just take a step back and think, could it be something autoimmune? Having said that, if I may, I just want to say that, I mentioned that rapid disease course, and on the other hand, it's important to stress that a slowly progressive disease cause does not exclude an autoimmune etiology.   Dr Smith: So, that was a great summary. Thank you. I don't know if you're familiar with the term “Aunt Minnie” (something I learned in medical school and radiology). There are certain findings that are “Aunt Minnie”, you know what “Aunt Minnie” looks like, and if you see these particular findings, you should really think about a specific disease - and I think you gave a lot of pearls in that answer, so I appreciate that. This may seem like a bit of a random question, but it's interesting that there are some of these phenotypes that do replicate genetic phenotypes, and you used episodic ataxia, which, in a younger individual, we think of a spectrum of various genetic disorders. Is that random, or are there instances where the underlying mutation in a genetic disorder actually serves as a target for autoimmunity in a later-onset autoimmune problem? Not that the mutation causes autoimmunity, but are there shared targets - in one disease it's the mutation, and another, there's an antibody that binds to the protein, for instance?   Dr Balint: That's an excellent topic, and even though it's not addressed in the Continuum article, I actually covered this in an article in Brain from 2018, where we also discuss parallels (immunogenetic parallels) with targets seen in genetic disease or in autoimmune disease, and there are actually some examples for cerebellar ataxia, and some of the targets are, indeed, the same for the antibodies and mutation. And some targets are a little bit more difficult, because for those, the antibodies would probably not be pathogenic, but it's more like an autoimmune overall target but it's T-cell mediated. But, for example, water-gated, um, calcium channels - we have antibodies and we have mutations. Or, another example would be glycine receptor antibodies give you acquired hyperekplexia, whereas the mutations give you hereditary hyperekplexia. So, there is, indeed, a bit of an overlap between autoimmune and genetic disorders, but often, also, like, the age at onset (because that might be the next question, the age at onset), and maybe family history and associated features, should help to distinguish the two. I think more from the pathophysiological point interesting, rather than clinically too confusing.   Dr Smith: Wow, that's really cool. So, another question I have is regarding antibody panels, right? And so, I think, oftentimes (at least around here), folks confronting an unusual phenotype will send the Mayo panel - they'll send autoimmune encephalitis or a paraneoplastic panel – and, you know, I think one of the challenges I have thinking about the spectrum of phenotypes that you described, I mean, if you recognize “Aunt Minnie”, then you know where to go, but it seems to me that there's a lot of these that maybe folks don't recognize “Aunt Minnie”. What is the diagnostic utility and pearls and pitfalls of ordering these panels when you're not really certain? In other words, is there a risk of a false positive if the pretest probability is low? So, I guess that's a long question, but do you have guidance about when we should and maybe when we should not be ordering these panels? So, you know, undifferentiated ataxia that's chronically progressive - should we be sending a panel or not? Patients who are later-onset acute, maybe so. So, what's the guidance on when to order the panel?   Dr Balint: It's a tricky topic also for many people in our practice, because, of course, as you said, we don't want to miss something, but, indeed, with any test which you order with a low pretest probability and which is not quite appropriate, you might have false positives, and that might cause much additional trouble in security, or maybe unnecessary and invasive immunotherapy with adverse effects – so, it's really important to think well about antibody testing. And, generally speaking, like always in medicine, we shouldn't order random tests, and antibody panels and neuronal antibodies are not designed as a screening test, so you need to have a phenotype and a reasonable suspicion - and clinical acumen is really key, and that's why also the article is so much focused on the phenotype. It's clearly not that any movement disorder patient who enters the outpatient clinic should get a blood test for antibodies that will likely cause harm, and it has been shown that these antibodies can be falsely positive, both in other diseases but also in healthy controls, and much depends also on which tests you use (but, let's not go into too much detail over here) - so, generally speaking, I would say if you have a suspicion of an autoimmune disease clinically (I mentioned some scenarios where you would think of an autoimmune disorder). And then, ataxias are, of course, a bit tricky, because often, we don't have too many other handles there, and there's still also a significant number of acquired late-onset ataxia where we don't know what the cause is. I think in the ataxia scenario, if I don't have a good answer or explanation, I would order antibody tests a bit more freely - I mean, if you do it properly, you do the serum and the CSF, and that also increases your sensitivity but also the specificities, so I wouldn't then just do the serum, but then go for serum and CSF. In other movement disorders, it depends also a little bit on the phenotype. So, somebody with a phenotype fitting well with Parkinson's disease, I wouldn't do any testing. Somebody with clear PSP phenotype without any red flags or not-fitting features, it is very unlikely to have an antibody finding, and this has been shown also in cohorts. But, if you have something which is not fitting in the phenotypes - for example, you have somebody where you think it might be a PSP phenotype with predominantly axial Parkinsonism falls, but you notice that the oculomotor disturbance is not a vertical gaze palsy, but a horizontal gaze palsy – so, it's not really fitting phenotype as you know it. That's a scenario where would probably think of antibody testing. Then, if you do the testing theorem - and CSF, in general, is gold standard - there are some antibodies where theorem is good enough (like, for example, with aquaporin-4 antibodies), but the reason why we do serum and CSF, as I mentioned, is the increased sensitivity and specificity. And nowadays, in the antibody world, we have something similar to the genetics - we have the variant of unknown significance and in the neurology world, we coin the term “antibody of unknown significance” to also give a name to the problem that, sometimes, we get a test result and it is difficult to interpret. Another handle over there would be to try to confirm the test result in another test method. So for example, if you have a cell-based assay with an antibody finding, you would like to confirm that on immunohistochemistry - the staining pattern is in keeping with that.   Dr Smith: So, Bettina, that was a really great and comprehensive answer to the question with a lot of pearls packed into it, and I think the idea that, you know, oftentimes, it's helpful to do both serum and CSF testing is important - also looking for staining to further confirm the diagnosis. And, I think one of the things that I was struck by in your response was the example of a PSP patient who instead of vertical gaze palsy had horizontal gaze palsy as a red flag, and I think a lot of our listeners are probably familiar with the idea that maybe hyperkinetic movement disorders might be autoimmune, or certainly rapidly progressive ataxia, but at least I don't think of Parkinsonian syndromes as often. I know there are some that we need to consider. Maybe you can give us some pearls about when we should consider antibody testing in a patient who has a Parkinson syndrome?   Dr Balint: So, I will not cover now the paraneoplastic Parkinsonian syndromes (because they typically develop as rapidly that you would anyway think about it, hopefully), but go more into those conditions which might mimic degenerative disease - and one of the most interesting antibodies in this regard is IgLON5, and you will be aware that it has been discovered in 2014 in patients who shared a characteristic sleep movement disorder (non-REM parasomnia). The spectrum has broadened a lot, and one possible manifestation is that it could come into the differential of Parkinsonian syndromes - so, for example, if you have axial Parkinsonism and a gaze palsy, you are in a PSP phenotype, but the red flag would be maybe if the eye movement disorders are not really fitting with the PSP phenotype. Also, in PSP patients, we don't expect parasomnias at night. If the bed partner is, for example, complaining that the patient is moving in his sleep and doing movements, then this would be a red flag, and in this context, you would think of IgLON5. IgLON5 could also give you Parkinsonism and cerebellar ataxia, and they might have dysautonomia, and, of course, with a sleep movement disorder, you are now in the ballpark of MSA phenotypes; however, if there are additional features (like, for example, fasciculations) which you don't expect in MSA, that would be, again, the red flag. So, typically, even in those differentials, there are some red flags on handles which would point you to the diagnosis - it is not that it completely mimics the phenotype of our default degenerative disease, but, sometimes, you need to hunt a little bit for those handles.   Dr Smith: So, Bettina, that's really interesting. I wanted to ask you about IgLON5, and in particular, the sleep phenotype, but, you know, I wonder whether there's a risk of just confusing this with REM sleep behavior disorder and a chronic Parkinsonian syndrome - what's the time course of this, and any other wisdom in terms of how to differentiate it from, you know, a more common neurodegenerative problem?   Dr Balint: So, the spectrum of sleep disorders in IgLON5 is actually a bit broad. The characteristic thing is the non-REM sleep parasomnia with the finalistic fine movements, but classic REM sleep behavior disorder has also been reported in these patients. And one of the tricky things is IgLON5 is a slowly progressive disease (some patients had symptoms for a decade prior to diagnosis), so it's really an important differential of autoimmune disease - but as mentioned, the features not fitting in, and they are typically also the cardinal features. So, gaze palsies are very frequent, ptosis, bulbar symptoms, vocal cord palsy, sleep movement disorders which might not fit to the original phenotype, and breathing problems (for example) so severe that they require a tracheostoma – so, these are some red flags which would alert you to this diagnosis of anti-IgLON5 disease.   Dr Smith: I'm curious, Bettina, how do you keep up on all of this and keep it all straight? Right, there's a lot of information, and as I was reading your article, you've got these wonderful tables - and in fact, this whole issue for our listeners feels that way. I've read several of these articles now, and I'm just curious what your strategy is to stay up to date and stay organized. You have to be very organized to be an autoimmune neurologist, it seems to me.   Dr Balint: And having a little bit of OCD helps clearly, as always, in neurology. I think it is just that I started to be interested in this area for a while and I have in my head the clinical phenotype to most important associated antibodies, and as the field continues, I just add up on that panel. But, I don't want people to be discouraged - you're right, many antibodies, but I think the point is not to know each and every antibody but to know in which scenario to think of an autoimmune syndrome and then to know where to look it up.   Dr Smith: Well, I think that's a great way of ending our conversation, Bettina. I think your article does a great job of that, and one of the things I love about Continuum is these articles serve as point-of-care tools. I think our conversation will also serve as a useful framework, because I think you've talked a lot about how to organize your thinking, and, you know, pearls for when we should be thinking about these disorders which are uncommon, but you certainly don't want to miss one because the therapy can be very effective. So, Bettina, thank you so much for joining me. This has been a really great conversation.   Dr Balint: Thank you so much, Gordon. Thank you very much for your good questions.   Dr Smith: So, again, today, I've had the great pleasure of interviewing Dr Bettina Balint, whose article on ataxia and other autoimmune movement disorders appears in the most recent issue of Continuum, which is on autoimmune neurology. Be sure to check out Continuum Audio episodes from this and other issues. And thanks to our listeners for joining us today.   Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use this link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at Continpub.com/AudioCME. Thank you for listening to Continuum Audio.

In this episode (you can watch on YouTube here!), we explore the potential of Hyperbaric Oxygen Therapy (HBOT) as a treatment to prevent the progression of Parkinson's Disease. HBOT involves breathing pure oxygen in a pressurized environment, which is believed to enhance the body's natural healing processes. But can it really slow down or even halt the progression of Parkinson's Disease?  We'll highlight: -What is Hyperbaric Oxygen Therapy and how does it work? -The science behind HBOT and its effects on brain health. -Current research and case studies on HBOT's impact on Parkinson's Disease. -Potential benefits and risks of using HBOT for Parkinson's patients. Join us as we explore this promising yet controversial treatment and what it could mean for the future of Parkinson's care. Don't forget to like, subscribe, and hit the notification bell for more videos on Parkinson's Disease treatments and research! Resources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138219/  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851727/ https://www.parkinsonsresource.org/news/articles/parkinsons-and-hyperbaric-oxygen-therapy/ Help to support this channel and out efforts to educate the world about Parkinson's Disease and get access to personalized content:  https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join  https://www.patreon.com/pdeducation Please be sure to give support to our sponsors: Comfort Linen (15% off entire order when applying the code PARKINSONSDISEASEEDUCATION at checkout) Kizik Shoes Orthofeet If you have products that you would like for me to review on the channel please send them here: Parkinson's Disease Education P.O. Box 1678 Broken Arrow, OK 74013 Medical Disclaimer: All information, content, and material of this podcast is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider.  Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #hyperbaricoxygentherapy #hyperbaricoxygen #mitochondria #oxidativestress

Megyn Kelly is joined by Batya Ungar-Sargon, author of "Second Class," to discuss where President Joe Biden has been since he's been disappeared by his party, how VP Kamala Harris has essentially replaced him as president, the "ritual humiliation" of Biden by his former friends and colleagues, why elites on the left hate JD Vance, the attempt to reframe the narrative around Harris, how the media is pushing Harris' “vibe” over actual policies, the full context about JD Vance's comments on having kids, the clickbait the left is portraying and the misleading quotes they are pulling, the reality it was a response to the cultural points about the benefits of not having kids, his own powerful family story, Megan Thee Stallion's performance at Kamala Harris' rally in Atlanta, Kid Rock's performance of a pretty raunchy song at the RNC, Megyn reading lyrics of each artist, and more. Then Dr. Drew, host of "Ask Dr. Drew," joins to discuss the ridiculous Pro-Kamala Harris Zoom calls segregated by race, the passive aggressive preachiness on display from the 'white women" call, the disgust that comes from it by the average person, Biden's symptoms and cognitive and physical health issues, how it's obvious he has Parkinsonism, what's going on with Harris' weird word salad answers, the tech censorship of Trump's assassination attempt, and more.Ungar-Sargon- https://www.amazon.com/Second-Class-Betrayed-Americas-Working/dp/1641773618Dr. Drew- https://drdrew.com/Tax Network USA: https://TNUSA.com/MEGYN or call 1-800-245-6000Done with Debt: https://www.donewithdebt.com/Follow The Megyn Kelly Show on all social platforms:YouTube: https://www.youtube.com/MegynKellyTwitter: http://Twitter.com/MegynKellyShowInstagram: http://Instagram.com/MegynKellyShowFacebook: http://Facebook.com/MegynKellyShow Find out more information at: https://www.devilmaycaremedia.com/megynkellyshow

In this episode, we delve into the role of NAD (Nicotinamide Adenine Dinucleotide) and its potential in treating Parkinson's Disease. NAD is a vital molecule involved in cellular energy production and DNA repair, but recent research suggests it may also play a crucial role in neuro-protection. How does NAD impact Parkinson's Disease? We'll explore: What is NAD and how does it function within our cells?  The connection between NAD and neurodegenerative diseases like Parkinson's.   Latest research findings on NAD's potential benefits for Parkinson's patients. How NAD supplementation could influence disease progression and symptoms. Join us as we uncover the science behind NAD and its promising potential in the fight against Parkinson's Disease. Remember to like, subscribe, and hit the notification bell to learn as much as possible about Parkinson's Disease. Resources: NADPARK Study (Full Text): https://www.cell.com/cell-metabolism/fulltext/S1550-4131%2822%2900045-6 Miscley et al ATPmax and NAD deficiency in PD: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961646/#B30-nutrients-15-00943 Need dedicated time to speak to a Parkinson's expert? Request a call here for up to 60 minutes: https://clarity.fm/pdeducation Help to support this channel and out efforts to educate the world about Parkinson's Disease and get access to personalized content:  https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join  https://www.patreon.com/pdeducation Please be sure to give support to our channel sponsors: Comfort Linen: https://comfortlinen.com/PARKINSONSDISEASEEDUCATION(15% off entire order when applying the code PARKINSONSDISEASEEDUCATION at checkout) Kizik Shoes: https://kizik.sjv.io/q4y1RL Orthofeet: https://lvnta.com/lv_0Pn1TAIM5VDdOHxlYG  If you have products that you would like for me to review on the channel please send them here: Parkinson's Disease Education P.O. Box 1678 Broken Arrow, OK 74013 Medical Disclaimer All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #atp #mitochondria #supplements

Identifying reliable biomarkers for the diagnosis and prognosis of Parkinson's disease and atypical parkinsonism would have substantial impacts on clinical trials and clinical practice. A particularly active area of research is the development of novel molecular imaging biomarkers that can be used in combination with common neuroimaging approaches. Dr. Antonio Strafella discusses current practices for using molecular imaging biomarkers in research and in the clinic, the process of developing new biomarkers, as well as promising biomarkers that are in development. He also discusses limitations, implementation challenges, and the potential use of AI to enhance diagnostics in the future. Antonio is the Krembil-Rossy Chair in Molecular Imaging of Neurodegenerative Diseases and Professor in the Department of Medicine within the Division of Neurology at the Toronto Western Hospital (University Health Network, University of Toronto). He also serves as Director of Clinical Research and Translation with the Temerty Faculty of Medicine at the University Toronto, and he is a movement disorder neurologist in the Edmond J. Safra Program in Parkinson's Disease and Morton & Gloria Shulman Movement Disorders Clinic at the Toronto Western Hospital.This podcast is geared toward researchers and clinicians. If you live with Parkinson's or have a friend or family member with PD, listen to The Michael J. Fox Foundation Parkinson's Podcast. Hear from scientists, doctors and people with Parkinson's on different aspects of life with the disease as well as research toward treatment breakthroughs at https://www.michaeljfox.org/podcasts.

Identifying reliable biomarkers for the diagnosis and prognosis of Parkinson's disease and atypical parkinsonism would have substantial impacts on clinical trials and clinical practice. A particularly active area of research is the development of novel molecular imaging biomarkers that can be used in combination with common neuroimaging approaches. Dr. Antonio Strafella discusses current practices for using molecular imaging biomarkers in research and in the clinic, the process of developing new biomarkers, as well as promising biomarkers that are in development. He also discusses limitations, implementation challenges, and the potential use of AI to enhance diagnostics in the future. Antonio is the Krembil-Rossy Chair in Molecular Imaging of Neurodegenerative Diseases and Professor in the Department of Medicine within the Division of Neurology at the Toronto Western Hospital (University Health Network, University of Toronto). He also serves as Director of Clinical Research and Translation with the Temerty Faculty of Medicine at the University Toronto, and he is a movement disorder neurologist in the Edmond J. Safra Program in Parkinson's Disease and Morton & Gloria Shulman Movement Disorders Clinic at the Toronto Western Hospital.This podcast is geared toward researchers and clinicians. If you live with Parkinson's or have a friend or family member with PD, listen to The Michael J. Fox Foundation Parkinson's Podcast. Hear from scientists, doctors and people with Parkinson's on different aspects of life with the disease as well as research toward treatment breakthroughs at https://www.michaeljfox.org/podcasts.

In this episode, we explore the potential role of Nrf2 (Nuclear factor erythroid 2–related factor 2) as an adjunct in the treatment of Parkinson's Disease. Nrf2 is a crucial protein that regulates the expression of antioxidant proteins and protects against oxidative damage triggered by injury and inflammation. But how does it relate to Parkinson's Disease?  We'll cover: -What is Nrf2 and how does it function in the body? -The connection between Nrf2 and neuroprotection. -The role of Nrf2 in reducing inflammation in the brain -The role Nrf2 plays in antioxidant response. Don't forget to like, subscribe, and hit the notification bell for more updates on Parkinson's research and treatment options! See episide on YouTube here. Here is a link to explore Nrf2 products on Amazon (LifeVantage is a very tried and true brand): https://amzn.to/3ziRxSV Here is the article referenced in this episode: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263373/ Join this channel to get access to member's only content and perks: https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join  https://www.patreon.com/pdeducation Medical Disclaimer All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #supplements #mitochondria #oxidativestress #antioxidants #nrf2 #inflammation #antiinflammatory

Today's show opens with more of a free-talk segment, moving from doing what you love to understanding the Machiavellian principle of ruling a people through both love and fear. Both can work, but, of the two, fear is preferred. This rolls right into the ongoing problem Democrats are having with a recalcitrant President Biden. Jake Tapper from CNN seems to be enjoying playing the part of a real journalist over the last several days. He is actually delving into facts and playing fair. I don't know how long it will last, but it's fun to watch. The Wall Street Journal printed a piece saying the German leadership was aware of Biden's physical failings as far back as a 2022 meeting. On the flip side, those already running the show need to protect their boss at all costs. They want to keep control and refuse to admit what we all know. Spokesman John Kirby tells CNN that Joe is lucid, clear, direct and in command of the context and the information. In fact, hailing Biden as the Adult among adults in the room, he later tells the White House Press Corps that Biden will soon be doing a “Big Boy” press conference. This same phrase is then echoed by White House Press Secretary Karine Jean-Pierre. How emasculating is that? The Democrat Party is only interested in absolute power. They don't care about Joe. They only care about staying in power forever. Look back over the last few years if not the last 10-15 and ask yourself which party is really going after “democracy.” Censorship, lawfare, kicking opponents of the ballot and throwing opponents in jail is something the Democrats have been using and pushing just to stay in power. There was a secret meeting in Washington, D.C. about replacing Joe Biden. One representative who walked out, when asked if they were all on the same page, said no. When asked to clarify, he said there were not even in the same book. We then continue with the Parkinsonism discussion. First, on NBC NOW, Dr. Tom Pitts, a Parkinson's expert, was discussing Joe's symptoms. It's a sobering discussion. This relates to the press finding out a Parkinson's doctor by the name of Dr. Kevin Cannard has visited the White House 10 times in the past year. This led to a heated discussion yesterday with Karine Jean-Pierre and CBS's Ed O'Keefe. To lighten things up a bit, we dive into a parody song from my good buddy Jim Gossett. Singing in the voice of President Obama, we get a variation of “Knock Three Times.” Polling isn't good for Joe, but, to be honest, with all that's happening it should be a lot worse. It goes to show the Democrats are going to cheat as much as they can. Which leads us to the SAVE Act, trying to make law that only Americans can vote in elections. The President said he would veto it and Democrat leadership is doing all they can to block it. That says it all, doesn't it? Speaker Mike Johnson says what we all already know. The Democrats have pushed the open borders to flood the country with people they want to vote for them. And, that is what I have been telling you for a very long time, now. Take a moment to rate and review the show and then share the episode on social media. You can find me on Facebook, X, Instagram, GETTR and TRUTH Social by searching for The Alan Sanders Show. You can also support the show by visiting my Patreon page!

Unleashed: The Political News Hour with Ted Noel MD – Joe Biden's public performances raise concerns about his health, specifically Parkinsonism. Observations of his stiffness, slow gait, and cognitive disturbances suggest severe neurological issues. An anonymous neurologist confirms these signs align with Parkinson's disease. The urgency for diagnosis and treatment is critical, impacting Biden's ability to fulfill presidential duties effectively.

In this episode, we take a closer look at glutathione and its potential role as a supplement in the treatment of Parkinson's Disease. Glutathione or GSH is an anti-oxidant, as with several supplements we have discussed on the podcast. But how effective is Glutathione for Parkinson's patients? We discuss the research and more. Resources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751460/  https://www.michaeljfox.org/grant/phase-iib-study-intranasal-glutathione-parkinsons-disease Start here on Amazon to find supplemental Glutathione. This one by NOW is highly rated and people really seem to get a lot of benefit: https://amzn.to/3RkF9YR Join this channel to get access to member's only content and perks:  https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join  https://www.patreon.com/pdeducation  Medical Disclaimer All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #supplements #glutathione #mitochondria #oxidativestress #antioxidants

In this episode, we take a closer look at creatine and its potential role as a supplement in the treatment of Parkinson's Disease. Creatine, commonly known for its use in sports and bodybuilding, has shown promise in recent studies as a neuro-protective agent. But how effective is it for Parkinson's patients? Be sure to watch on YouTube for en enhanced experience!! Resources: https://www.mdpi.com/2072-6643/14/3/529 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457735/ Start here on Amazon to find supplemental Creatine. This one is highly rated on Amazon and has a 500 count (about a 4 month supply) or you can get a bottle of up to 1500 capsules!! https://amzn.to/3UYwnjZ Join this channel to get access to member's only content and perks:  https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join  https://www.patreon.com/pdeducation  Medical Disclaimer All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #supplements #creatine #mitochondria #oxidativestress #antioxidants

In this episode (video here on YouTube), we explore the potential of Coenzyme Q10 (CoQ10), also known as Ubiquinone, in the treatment of Parkinson's disease symptoms.  CoQ10, a naturally occurring compound found in every cell of the body, plays a crucial role in mitochondrial function and energy production. Research suggests that individuals with Parkinson's disease may have lower levels of CoQ10 in their brains, potentially contributing to mitochondrial dysfunction and oxidative stress.  By supplementing with CoQ10, individuals may be able to bolster mitochondrial function, enhance cellular energy production, and reduce oxidative damage—all of which are key factors in the progression of Parkinson's disease. While more research is needed to fully understand the role of CoQ10 in treating Parkinson's disease, the current evidence is encouraging. Join us as we delve into the science behind CoQ10 and its potential to offer hope to those living with Parkinson's disease. Subscribe to our channel for more informative content on health, wellness, and the latest research on Parkinson's Disease. Start here on Amazon to find supplemental CoQ10. This one is the best rated on Amazon and has a 4 month supply! https://amzn.to/4bnDER3 Join this channel to get access to member's only content and perks: https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join  https://www.patreon.com/pdeducation Medical Disclaimer All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #supplements #coq10 #mitochondria #oxidativestress #antioxidants

In this episode, we delve into the powerful connection between the ketogenic diet, supplements, and their role in healing sick mitochondria, as well as their potential to treat Parkinson's disease. As mentioned in the previous video, mitochondria are often referred to as the "powerhouse of the cell", responsible for producing energy. However, when these vital organelles become dysfunctional, it can lead to a range of health issues, including Parkinson's disease.  The ketogenic diet, known for its low-carbohydrate, high-fat approach, has shown promise in supporting mitochondrial health. By reducing the reliance on glucose for energy and switching to ketones (increased ketosis), which are produced from fats, this diet may help to reduce oxidative stress and inflammation, both of which can contribute to mitochondrial dysfunction. Furthermore, certain supplements have been identified as potential allies in the quest for mitochondrial health. Join us as we explore the science behind the keto diet, supplements, and their potential to heal sick mitochondria and offer hope for those living with Parkinson's disease. Subscribe to our channel for more in-depth discussions on health, wellness, and cutting-edge research. AS MENTIONED IN THIS EPISODE: Brain Energy by Dr. Christopher Palmer, MD: https://amzn.to/3JuPCfX Parkinson's and the B1 Therapy by Dr. Daphne Bryan, PhD: https://amzn.to/3JuPCfX Life with Parkinson's Merch (David Gebhart is a PwP and a fellow YouTuber): https://www.lifewithparkinsons.ca/lwp-merchandise Join our memberships to get access to member's only content and perks: https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join https://www.patreon.com/pdeducation  Medical Disclaimer All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider.  Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #ketodiet #mitochondrialhealth #ketosis #cellbiology #oxidativestress

*For the BEST visual experience, I highly suggest watching this podcast episode on YouTube here.* In this episode I do my best to break down and to simplify the cellular processes that result in abnormal aggregation of the protein alpha-synuclein in the nerve cells that produce #dopamine and how this leads to most of, if not all of, the problems caused by PD. In this video I reference this paper regarding the endo-lysosomal (E-L) pathway in cells, genetic links to PD, and how alpha-synuclein aggregates and what issues this causes: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707858/ Please please consider reading this amazing book by Dr. Christopher Palmer, MD on the role of mitochondria in neurological diseases like PD! It is a MUST read: https://amzn.to/49eNbZs Join this channel to get access to member's only content and perks: https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join  https://www.patreon.com/pdeducation Medical Disclaimer: All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use. #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #neuroscience #cellbiology #education

Dr. Jeff Ratliff discusses how arm swings can help distinguish Parkinson disease from functional Parkinsonism. Show Reference:  https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mdc3.13952 

In part two of this two-part series, Dr. Jeff Ratliff and Dr. Jason Margolesky discuss what his team found when they looked for the presence or absence of blepharoclonus in patients with Parkinson disease or other Parkinsonian disorders.  Show reference:  https://www.neurology.org/doi/abs/10.1212/CPJ.0000000000200240

Dr. Jeff Ratliff talks with Dr. Jason Margolesky about the frequency of blepharoclonus in Parkinson disease and atypical Parkinsonian disorders to explore whether this clinical phenomenology may be useful in the evaluation and diagnosis of patients with Parkinsonism. Read the related article in Neurology: Clinical Practice.  Disclosures can be found at Neurology.org.

Thank you for tuning in for another episode of Life's Best Medicine. Mimi Morgan grew up in Kentucky where, despite developing asthma at the age of two, she spent lots of time outdoors, taking care of horses, and riding horses. Unfortunately, her low fat, low protein way of eating ultimately brought about some serious health issues. She was diagnosed with rheumatoid arthritis and Parkinsonism. Shortly thereafter, she was diagnosed with Spinal Osteomyelitis. Her health was steadily declining. It was not until she finally reduced her carbs and increased her protein and fat that she began to see some pretty amazing results. Over time she was even able to reduce her medications from 13 to 0! Thank you for listening. Have a blessed day and stay healthy!   Links:   Mimi Morgan: Twitter Linktree   Dr. Brian Lenzkes:  Website Low Carb MD Podcast   HLTH Code: HLTH Code Promo Code: METHEALTH HLTH Code Website   Keto Mojo: Keto Mojo