Podcasts about postmenopausal women

Osteoporosis silently compromises bone strength, leading to increased fracture risk, especially in women over 50. In this comprehensive video, we delve into natural and science-backed strategies to enhance bone density and combat osteoporosis. Topics Covered: Exercise & Mechanical Loading: Importance of weight-bearing and resistance exercises. Insights into OsteoStrong® sessions and their impact on bone mineral density.  Overview of the OsteoBoost® belt and its FDA clearance.  Advanced Therapies: Benefits of Hyperbaric Oxygen Therapy (HBOT) in bone healing.  Role of Red/Near-Infrared Light Therapy in bone regeneration.  Discussion on peptide therapies like Teriparatide and Ibutamoren. Nutrition & Supplementation: Efficacy of AlgaeCal® in improving bone mineral density.  Synergistic effects of Vitamin D3 and K2 on bone health.  Benefits of collagen peptides and tocotrienol-rich Vitamin E.  Hormonal Health: Impact of estrogen, progesterone, testosterone, and DHEA on bone density.  Considerations for hormone replacement therapy. Medications & Monitoring: Risks associated with bisphosphonates and long-term use. Importance of DEXA scans in monitoring bone health. Effects of steroid medications on bone strength.  Featured Expert: Dr. Doug Lucas, a renowned orthopedic surgeon, shares his insights on optimising bone health through a holistic approach. Learn more about his work at drdouglucas.com. Related Podcast: For an in-depth discussion on osteoporosis and bone health, watch the following podcast: YouTube Video Empower yourself with knowledge and take proactive steps towards stronger bones and a healthier future. References: Mortality and cause of death in hip fracture patients aged 65 or older.  Effective Brief, Low-impact, High-intensity Osteogenic Loading in Postmenopausal Women.  Wearable vibration device - FDA clearance for OsteoBoost Belt.  Hyperbaric oxygen therapy for promoting fracture healing.  NIR light-assisted phototherapies for bone-related diseases.  Effect of Teriparatide on Bone Mineral Density and Bone Markers.  Treatment with the oral growth hormone secretagogue MK-677.  A 7-Year Longitudinal Trial of the Safety and Efficacy of AlgaeCal.  Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density.  Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers.  Tocotrienol supplementation in postmenopausal osteoporosis.  A systematic review and meta-analysis of DHEA supplementation on bone mineral density.  Glucocorticoid-Induced Osteoporosis Clinical Practice Guidelines.  

In this episode of the Movement Logic Podcast, hosts Laurel Beversdorf and Dr. Sarah Court critically examine common beliefs surrounding spinal flexion exercises and osteoporosis, particularly from a yoga and Pilates perspective. They delve into two pivotal studies on exercise and fracture risk, both led by Dr. Mehrsheed Sinaki, a renowned specialist in physical medicine and rehabilitation at the Mayo Clinic in Rochester, Minnesota.The first study, Postmenopausal Spinal Osteoporosis: Flexion versus Extension Exercises, is frequently cited on Pilates websites and in yoga and Pilates teacher trainings as evidence that spinal flexion is risky for individuals with osteoporosis—even during bodyweight exercises. However, despite its widespread use to justify movement restrictions, the study has notable methodological flaws. The second study, Stronger Back Muscles Reduce the Incidence of Vertebral Fractures: A Prospective 10-Year Follow-up of Postmenopausal Women, suggests that progressively overloaded back strengthening exercises can reduce fracture risk—even if the strengthening occurred only for a few years in the distant past. Yet, this study also has its own limitations.When viewed together, these studies present an intriguing contrast: one warns of the potential dangers of spinal flexion (even under low loads) based on weak evidence, while the other highlights the lasting protective benefits of strength training. Laurel and Sarah explore why bodyweight spinal flexion is often singled out as risky and question whether this caution is always justified.They also discuss the ethical implications and the boundaries of a movement teacher's scope of practice—particularly when making broad recommendations to avoid certain movements based on limited or flawed research. The hosts emphasize the importance of individualized context in exercise prescriptions, the need to follow medical guidance from a student's doctor, the evidence-backed benefits of strength training, and the necessity of empowering students with the autonomy to make informed movement choices.Get on the wait list for our Bone Density Course: Lift for LongevityFollow Movement Logic on Instagram00:56 Podcast Production & Content Creation01:33 Bone Density & Squat Depth02:20 Benefits of Full ROM Strength Training08:24 Is Spinal Flexion Dangerous for OP?10:00 Issues with Yoga/Pilates for OP Classes18:43 1984 Paper: Flexion vs. Extension for OP40:22 Flaws in the 1984 Study41:57 2002 Study: Stronger Back Muscles & Fractures43:03 2002 Study Design & Methods46:35 2002 Study Key Findings52:09 2002 Study Limitations56:30 Practical Takeaways01:06:15 Ethics for Movement Teachers01:17:43 ConclusionReferences:Episode 77: Make Dr. Loren Fishman Make SenseEpisode 92: Are You Getting Dexa Scammed? 1984 Sinaki paper 2002 Sinaki paper

Weighted vests have gained popularity as a tool for improving strength, bone density, and overall fitness. For women in premenopause, menopause, and postmenopause, the potential benefits of using a weighted vest may be especially valuable. But what are the actual benefits, and are there any risks to be aware of? Let's dive into the purpose, benefits, and precautions of using a weighted vest during midlife and beyond. Instagram: www. instagram.com/wholehealthempower FB Group: https://www.facebook.com/groups/619968441854520/ 3 Way to eat better workbook: https://triciard.com/workbook/ GRAB YOUR FREEBIE HERE! 5 things you should be doing today if you are over 40! https://upbeat-hustler-2294.ck.page/06d0e2ccf9 Whole Health Empowerment FB group: https://www.facebook.com/groups/wholehealthempower Website: https://triciard.com/

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In this episode, Dr. Nazim Gherabi (DZ) discusses his systematic review on the treatment of urge incontinence in postmenopausal women.Dr. Gherabi talks about the most effective therapeutic approaches, and evaluates current evidence. He highlights gaps in research and offers insights into tailoring treatments to improve patient outcomes. This episode provides valuable perspectives for clinicians and researchers interested in advancing care for this prevalent condition in postmenopausal women.For more EAU podcasts, please go to your favourite podcast app and subscribe to our podcast channel for regular updates: Apple Podcasts, Spotify, EAU YouTube channel.

For the longest time, endurance athletes avoided the weight room, afraid unwanted muscles would weigh them down, while strength athletes all but kicked cardio to the curb. Now we know that no matter if you're running an ultra or competing in a CrossFit competition, the right blend of cardio and strength is the secret sauce for success–especially once you hit midlife and menopause. This week, renowned exercise physiologist Dr. Alyssa Olenick dives in on how our hormones impact our muscles, metabolism, and general physiology, and how the right blend of hybrid training can help you stay strong, fit, healthy, and injury free during and beyond the menopause transition.Dr. Alyssa Olenick holds a PhD in exercise physiology and is a certified sports nutritionist and CrossFit Level 2 Trainer. Alyssa completed her doctoral training in exercise and human metabolism, sex differences, and menstrual cycle physiology. She also completed a postdoctoral research fellow investigating the areas of menopause and metabolism. As a coach she specializes in the areas of endurance, strength, and hybrid training. She runs her online business ‘Doc Lyss Fitness' and training programs ‘The Lyss Method'. She is also a strength athlete, ultra-marathon runner, and all-around fitness lover who is passionate about educating people on science-based fitness to get them into the gyms and on the roads/trails — or often, doing both at the same time! You can learn more about Dr. Alyssa Olenick and her programs at www.doclyssfitness.comResourcesHow to exercise for menopause with Dr. Alyssa Olenick on YouTubeMenopausal Women Need Unique Muscle Making Guidelines, Feisty Menopause BlogResistance training alters body composition in middle-aged women depending on menopause - A 20-week control trial, BMC Women's HealthEffect of Concurrent Training on Body Composition and Gut Microbiota in Postmenopausal Women with Overweight or Obesity, Medicine & Science in Sports & ExerciseJoin the Feisty Girona Gravel Camp: https://www.thomsonbiketours.com/trips/feisty-girona-gravel-camp/ Subscribe to the Feisty 40+ newsletter: https://feistymedia.ac-page.com/feisty-40-sign-up-page Follow Us on Instagram:Feisty Menopause: @feistymenopause Hit Play Not Pause Facebook Group: https://www.facebook.com/groups/807943973376099 Support our Partners:Midi Health: You Deserve to Feel Great. Book your virtual visit today at https://www.joinmidi.com/ Nutrisense: Go to nutrisense.io/hitplay and book a call with a Registered Dietitian Previnex: Get 15% off your first order with code HITPLAY at https://www.previnex.com/ This podcast uses the following third-party services for analysis: Spotify Ad Analytics - https://www.spotify.com/us/legal/ad-analytics-privacy-policy/Podcorn - https://podcorn.com/privacyPodscribe - https://podscribe.com/privacy

What if your menopause phase is not what you were taught it was: the end of it all, the ugly, the shameful and just straight uncomfortable stage? What if it soooooo much more than that? What if there are ways that you can tap into the magic and power that it actually is? OOOOOHHHHHH juiciness coming your way! Today we're talking about The twisted way we've been taught to think about menopause Powerful Cultural ancient beliefs around menopause The cultural, historical, and magical power that connects belly dancing and menopause Why the Crone phase of womanhood is thought to be the most powerful in a woman's lifeWith Vanessa Nixon, Author of Best Seller: Meno-Morphosis~Rituals, Spells and Natural Remedies for Peri, Mid and Postmenopausal Women. You can connect with the mid-life goddess at the links below.HerbsofGraceHealingArts.comYou Can Feel Marvelous in Mid-Life Naturally! FB GroupHerbsofGrace.comNatural Women who love Natural Makeup FB Group********Do you feel called to join the Goddess Collective? Let's talk about it. Schedule a call with me here: https://link.latoyazavala.com/widget/bookings/chatwithlatoyaWhat if you had a co-working space that led with an energetic activation to get you aligned with your purpose, your infinite potentiality, your clarity and your most creative frequency? Introducing Goddess Get Sht Done Sessions! Find out more:https://goddessgsd.latoyazavala.com/Find me on Youtube: https://www.youtube.com/channel/UCz0to_JubLqzQS1OuZdbnuQWanna have your Vedic Birth Chart Read: LIfePath Sync: https://link.latoyazavala.com/widget/bookings/yourlifepathFor more juiciness drop by my Website: https://www.latoyazavala.comTo get your copy of my explosive, raw, and down to your every day life play book on stopping the self-sabotage, get it here: https://payhip.com/b/HngNU**********

Alkaline water's popularity just won't quit. Sales have grown every year since 2013. But do great sales mean that it's worth drinking—and are the so-called benefits of alkaline water like preventing cancer, promoting weight loss or improving bone density legit? That's what we break down in this very first episode of “waste of money or worth it”?   Sources for this episode include: Effect of Alkaline Drinking Water on Bone Density of Postmenopausal Women with Osteoporosis Associations of alkaline water with metabolic risks, sleep quality, muscle strength: A cross-sectional study among postmenopausal women Systematic review of the association between dietary acid load, alkaline water and cancer The effects of ingestion of hydrogen-dissolved alkaline electrolyzed water on stool consistency and gut microbiota: a double-blind randomized trial   Thank you for listening to The Happy Eating Podcast. Tune in weekly on Thursdays for new episodes! For even more Happy Eating, head to our website!  https://www.happyeatingpodcast.com Learn More About Our Hosts:  Carolyn Williams PhD, RD: Instagram: https://www.instagram.com/realfoodreallife_rd/ Website: https://www.carolynwilliamsrd.com Facebook: https://www.facebook.com/RealFoodRealLifeRD/ Brierley Horton, MS, RD Instagram: https://www.instagram.com/brierleyhorton/ Got a question or comment for the pod? Please shoot us a message!  happyeatingpodcast@gmail.com Produced by Lester Nuby OE Productions

Alkaline water's popularity just won't quit. Sales have grown every year since 2013. But do great sales mean that it's worth drinking—and are the so-called benefits of alkaline water like preventing cancer, promoting weight loss or improving bone density legit? That's what we break down in this very first episode of “waste of money or worth it”?   Sources for this episode include: Effect of Alkaline Drinking Water on Bone Density of Postmenopausal Women with Osteoporosis Associations of alkaline water with metabolic risks, sleep quality, muscle strength: A cross-sectional study among postmenopausal women Systematic review of the association between dietary acid load, alkaline water and cancer The effects of ingestion of hydrogen-dissolved alkaline electrolyzed water on stool consistency and gut microbiota: a double-blind randomized trial   Thank you for listening to The Happy Eating Podcast. Tune in weekly on Thursdays for new episodes! For even more Happy Eating, head to our website!  https://www.happyeatingpodcast.com Learn More About Our Hosts:  Carolyn Williams PhD, RD: Instagram: https://www.instagram.com/realfoodreallife_rd/ Website: https://www.carolynwilliamsrd.com Facebook: https://www.facebook.com/RealFoodRealLifeRD/ Brierley Horton, MS, RD Instagram: https://www.instagram.com/brierleyhorton/ Got a question or comment for the pod? Please shoot us a message!  happyeatingpodcast@gmail.com Produced by Lester Nuby OE Productions

Was man teilweise über Vitamin D hört, klingt fast zu schön, um wahr zu sein. Andererseits deuten hunderte verschiedener Forschungsarbeiten darauf hin, dass Vitamin D zur Vorbeugung einer Reihe von Krankheiten beitragen kann – darunter Osteoporose, Depression, Autoimmun- und Herz-Kreislauf-Erkrankungen. Ärzte empfehlen es. Gesundheits- und Fitnesspodcaster sprechen darüber. Vielleicht geht Dir sogar Deine Lieblingstante damit auf die Nerven. Bei all dem Hype ist die Frage berechtigt: "Solltest Du Vitamin D einnehmen?" Hier sind die Antworten – und die neuesten Fakten über ein faszinierendes Vitamin, das ein wahrer Verwandlungskünstler ist. ____________ *WERBUNG: KoRoDrogerie.de: 5% Ermäßigung auf alles mit dem Code „FMM“ beim Checkout. ____________ Ressourcen zur Folge: Literatur: Ratgeber Nahrungsergänzung – Mark Maslow (kostenlos auf MarathonFitness) Blut: Die Geheimnisse unseres flüssigen Organs* – Ulrich Strunz (Heyne) Vitamin D* – Uwe Gröber, Michael F. Holick (Wissenschaftl. Verlagsgesellschaft) Blutuntersuchung (Selbsttest): Vitamin D Test* von Medivere Präparate: D-Form 2.000 K2+* von FormMed D-Form 2.000 K2+ vegan* von FormMed ____________

Currently, there are more than 30 FDA-approved testosterone products for men, but none for women.

In this episode of the Well Beyond 40 Podcast, we're diving into the crucial connection between your diet and hormone balance—especially for women over 40. Did you know that nearly half of all women experience some form of hormonal imbalance that can disrupt everything from mood and weight to sleep and stress levels? The great news is that what you eat can have a significant impact on restoring that balance. Join me as I share five powerful foods that can help you get your hormones back on track. We're talking about the surprising superpowers of certain vegetables and how they help manage estrogen levels and support detoxification. I'll also reveal a tiny seed that packs a punch in balancing estrogen and progesterone and why they should be a staple in your diet. Plus, we'll discuss foods with hormone-friendly fats and how these delicious options can improve everything from cell health to hormone receptor sensitivity. If you're looking for simple, practical changes that can make a big difference in how you feel every day, this episode is for you. Tune in to discover how these foods can help you look and feel your best, and take control of your health journey! FULL show notes: https://www.jjvirgin.com/5foodsforwomentoeat 7-Day Eat Protein First Challenge: http://jjvirgin.com/proteinfirst Vital Choice wild-caught seafood: https://vitalchoice.sjv.io/daKYGy Reignite Wellness™ Magnesium Body Calm: https://reignitewellness.com/products/magnesium-body-calm Reignite Wellness™ Plant-Based & Paleo-Inspired All-In-One Shakes: https://reignitewellness.com/collections/shakes Reignite Wellness™ Omega Plus: https://reignitewellness.com/products/omega-plus Download my FREE Best Rest Sleep Cheat Sheet: https://jjvirgin.com/sleep Get 60 FREE delicious, protein-packed shake recipes in my Eat Protein First Smoothie Guide: https://jjvirgin.com/smoothie Study: 11 unexpected signs of hormonal imbalance: https://www.northwell.edu/obstetrics-and-gynecology/fertility/expert-insights/11-unexpected-signs-of-hormonal-imbalance#:~:text=Statistics%20show%20that%2080%20percent,manifested%20due%20to%20hormonal%20irregularities. Study: Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis: https://consensus.app/papers/vegetables-cancer-risk-epidemiologic-evidence-basis-higdon/76be881f2e415a40a80cf54675408bd9/?utm_source=chatgpt Study: Flaxseed Consumption Influences Endogenous Hormone Concentrations in Postmenopausal Women: https://www.tandfonline.com/doi/abs/10.1207/S15327914nc391_8 Study: Women and Omega-3 Fatty Acids: https://consensus.app/papers/women-omega3-fatty-acids-saldeen/b30be32ee8855035a5bb90779acdb013/?utm_source=chatgpt Study: Assessment of Total Fat and Fatty Acids in Walnuts Using Near-Infrared Hyperspectral Imaging: https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2021.729880/full Study: Walnuts, Long-Chain Polyunsaturated Fatty Acids, and Adolescent Brain Development: Protocol for the Walnuts Smart Snack Dietary Intervention Trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217431/ Study: Omega-3 ALA: https://walnuts.org/nutrition/nutrition-info/alpha-linolenic-acid/ Episode Sponsors:  Try Timeline: https://www.timelinenutrition.com/shop?rfsn=7082975.4b75243 Use code JJ10 for 10% off all products Go to qualialife.com/VIRGINWELLNESS to try Qualia risk-free for up to 100 days and code VIRGINWELLNESS for an additional 15% off  

Thousands of women in England who have gone through the menopause could benefit from a new drug on the NHS, called Abaloparatide, that reduces the risk of bone fractures. Unique collection of technology memorabilia up for auction, including the original Apple-1 computer from Steve Jobs' desk, a letter signed by Albert Einstein to President Franklin D. Roosevelt warning about Nazi Germany's nuclear weapons research and America's first spacewalk suit.Also in this episode:Call of Duty: Black Ops 6's Zombies trailerWhy our 3ft ancestors were real ‘Hobbits'London's hottest Tube lines revealedOlympics Paris 2024: running track made from seashells‘World's oldest calendar' found by archaeologists. Hosted on Acast. See acast.com/privacy for more information.

It turns out everything you've been told about cholesterol and heart disease is wrong. Get ready for the mind-blowing truth from my guest this week, Dr. Philip Ovadia, a cardiothoracic surgeon who lost 100 lbs and now dedicates his life to keeping people off his operating table through lifestyle changes. For years, we've been told that cholesterol is public enemy number one when it comes to heart health. But guess what? It's NOT true. The real culprits behind heart disease aren't what you think they are. And it's time we set the record straight. The Knew Method Live is a show broadcast live by Dr. Efrat Lamandre every week with the express purpose of providing free, factual, and practical functional medicine tips to help people prevent disease naturally. Through giving healthy nutrition tips, tips on intermittent fasting, managing stress through diet, and advocating self-improvement for her patients, Doctor E hopes to help you take control of your health destiny and become the GameChanger in your life. 00:00 Introduction 00:14 Overview of Dr. Ovadia's Book and Mission 00:30 The Truth About Heart Disease 01:10 Common Lies About Heart Disease 02:01 Dietary Cholesterol and Heart Disease 03:01 Historical Context of Heart Disease 05:45 The Role of Dietary Fat and Sugar 06:20 Insulin Resistance and Heart Disease 08:30 The Role of Inflammation 10:00 Quality vs. Quantity of Cholesterol 12:30 Postmenopausal Women and Cholesterol 14:01 Testing for Heart Disease 14:40 Importance of Coronary Artery Calcium Score (CAC) 16:00 Blood Tests vs. Imaging 17:50 The CAC Scan as a Heart Mammogram 18:50 Coronary CT Angiography (CCTA) 20:30 Real-World Examples and Cholesterol Context 21:00 Advanced Lipid Panel and Insulin Resistance 23:20 When to Consider Statins 24:40 Risks of Statins 26:00 Mechanism and Side Effects of Statins 29:20 Insulin Resistance and Statin Controversy 32:50 Patient Empowerment and Finding the Right Care 36:00 Closing Remarks and Contact Information Check us out on social media: theknewmethod.com/instagram theknewmethod.com/facebook theknewmethod.com/tiktok

The Role of Exercise in Menopausal Mood Management Feeling the mood swings that come with menopause? Crazy for a better mood in menopause? You're not alone. This episode dives into how regular exercise can be a powerful tool for managing mood, reducing anxiety, and boosting overall well-being during the transitional phase to menopause. Get ready to feel empowered with every step, stretch, and lift. Questions We Answer In This Episode: How does physical activity impact mood during menopause? [00:01:00] What types of exercise are most effective for mood management in menopausal women? [00:12:40] How does exercise reduce symptoms of anxiety and depression linked to menopause? [00:12:40] What are easy ways to incorporate more mood-boosting activities into daily life? [00:17:00] How long should you exercise to feel the mood-enhancing benefits? [00:17:20] Can exercise routines be adjusted based on menopausal symptoms? [00:16:20] Hormonal Fluctuations: Declining estrogen and progesterone levels affect neurotransmitters like serotonin and dopamine, which regulate mood and well-being, causing mood swings and anxiety. Sleep Disturbances: Menopause-related sleep issues, such as difficulty sleeping and poor sleep quality, worsen mood swings and anxiety due to disrupted sleep patterns. Psychosocial Factors: Life changes during menopause, including shifts in roles, relationships, and concerns about aging, contribute to stress and mood disturbances. Neurological Changes: Lower estrogen levels impact brain function, affecting emotional processing and stress response, making women more prone to mood swings and anxiety. Physical Health Changes: Symptoms like hot flashes, night sweats, and physical discomfort add to emotional distress and anxiety, further destabilizing mood. The study "Impact of Physical Activity on Physical and Mental Health of Postmenopausal Women" by S Kalra, J Yadav, and P Ajmera reviews the benefits of physical activity and psychological health for postmenopausal women. The physical benefits of exercise include improved cardiovascular health, increased bone density, and enhanced overall physical functioning. Psychologically, regular physical activity reduces symptoms of depression and anxiety, enhances mood stability, and mitigates mood swings and irritability often associated with menopause. Different types of exercise programs, including aerobic exercises, strength training, and flexibility routines, all positively impact mental health outcomes for postmenopausal women. The study consolidates existing research, highlighting exercise as a comprehensive therapeutic tool for managing menopausal changes. Other Episodes You Might Like: That Gut Feeling is Real How Gut Impacts Mood: https://www.flippingfifty.com/that-gut-feeling/ 7 Mental Health Benefits from Exercise That You'll Love: https://www.flippingfifty.com/mental-health-benefits/ Reference: Impact of Physical Activity on Physical and Mental Health of Postmenopausal Women: A Systematic Review by S Kalra, J Yadav, and P Ajmera, published in the Journal of Clinical & Experimental Research in 2022. This systematic review analyzes the impact of physical activity on both the physical and psychological health of postmenopausal women, including mood and anxiety alterations due to different exercise programs.

BUFFALO, NY- June 10, 2024 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 10, entitled, “Relationships of depression and antidepressant use with epigenetic age acceleration and all-cause mortality among postmenopausal women.” In this new study, researchers May A. Beydoun, Hind A. Beydoun, Jason Ashe, Michael F. Georgescu, Steve Horvath, Ake Lu, Anthony S. Zannas, Aladdin H. Shadyab, Su Yon Jung, Sylvia Wassertheil-Smoller, Ramon Casanova, Alan B. Zonderman, and Robert L. Brunner from the National Institute on Aging, U.S. Department of Veterans Affairs (Washington, DC), University of Texas Health Science Center at Houston, University of California Los Angeles, University of North Carolina at Chapel Hill, University of California San Diego, Albert Einstein College of Medicine, Wake Forest University School of Medicine, and University of Nevada Reno investigated relations of depressive symptoms, antidepressant use, and epigenetic age acceleration with all-cause mortality risk among postmenopausal women. “Frequently under-recognized depression is a major contributor to the Global Burden of Diseases [1, 2] while being the most prevalent mental illness among geriatric populations [2].” Data were analyzed from ≤1,900 participants in the Women's Health Initiative study testing four-way decomposition models. After a median 20.4y follow-up, 1,161 deaths occurred. Approximately 11% had elevated depressive symptoms (EDS+), 7% were taking antidepressant medication at baseline (ANTIDEP+), while 16.5% fell into either category (EDS_ANTIDEP+). Baseline ANTIDEP+, longitudinal transition into ANTIDEP+ and accelerated epigenetic aging directly predicted increased mortality risk. GrimAge DNA methylation age acceleration (AgeAccelGrim) partially mediated total effects of baseline ANTIDEP+ and EDS_ANTIDEP+ on all-cause mortality risk in socio-demographic factors-adjusted models (Pure Indirect Effect >0, P < 0.05; Total Effect >0, P < 0.05). Thus, higher AgeAccelGrim partially explained the relationship between antidepressant use and increased all-cause mortality risk, though only prior to controlling for lifestyle and health-related factors. “Antidepressant use and epigenetic age acceleration independently predicted increased all-cause mortality risk. Further studies are needed in varying populations.” DOI - https://doi.org/10.18632/aging.205868 Corresponding author - May A. Beydoun - baydounm@mail.nih.gov Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205868 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, depressive symptoms, epigenetic age acceleration, mortality About Aging-US Aging publishes research papers in all fields of aging research, including but not limited to aging processes (from yeast to mammals), cellular senescence, age-related diseases (such as cancer and Alzheimer's disease) and their prevention and treatment, anti-aging strategies and drug development, and, importantly, the role of signal transduction pathways in aging (such as mTOR) and potential approaches to modulate these signaling pathways to extend lifespan. Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

The truth is, most fitness advice isn't designed with the unique needs and challenges of mid-life and beyond in mind. Have you ever felt like you're stuck in a rut, despite your best efforts? As our bodies evolve and change, so too must our approach to health and well-being. Chasing numbers on the scale or adhering to one-size-fits-all routines can leave us feeling frustrated, depleted, and disconnected from our own bodies. It's time to stop blindly following generic health advice and start paying attention to what your body is telling you. Your body has its own alarm system, and it lets you know when something is wrong.. Together, we'll explore why traditional approaches often miss the mark, and reveal the key strategies for optimizing your health, energy, and vitality at any age. The Knew Method Live is a show broadcast live by Dr. Efrat Lamandre every week with the express purpose of providing free, factual, and practical functional medicine tips to help people prevent disease naturally. Through giving healthy nutrition tips, tips on intermittent fasting, managing stress through diet, and advocating self-improvement for her patients, Doctor E hopes to help you take control of your health destiny and become the GameChanger in your life.    00:00 Introduction 00:14 Special Guest Introduction: Debra Atkinson 00:30 Importance of Understanding Exercise for Women 00:45 Misconceptions in Fitness Industry 01:00 The Problem with General Fitness Guidelines 01:19 Gender Differences in Exercise Research 01:30 Specific Exercise Needs for Women 02:22 Importance of Individualized Exercise Plans 02:44 Changing Body Composition Over Weight Loss 03:36 Benefits of Gaining Lean Muscle Mass 04:12 Exercise as Medicine 05:00 Importance of Strength Training for Women 05:50 Exercise Guidelines for Different Life Stages 06:47 Exercise Recommendations for Teenagers 07:47 Encouraging Young Women to Lift Weights 08:45 Weight Training Benefits for Women 09:09 Importance of Protein for Postmenopausal Women 10:13 Strength Training for Older Women 11:04 Goals for Longevity and Independence 11:56 Importance of High-Intensity Training 12:44 Adapting Exercise to Your Needs 14:01 Avoiding Quick Fixes and Focusing on Long-Term Goals 14:51 Addressing Osteopenia and Osteoporosis 15:59 High-Intensity Exercise for Postmenopausal Women 17:04 Benefits of Strength Training for Visceral Belly Fat 18:04 Long-Term Health Goals and Sustainable Exercise 19:01 Overcoming Fear of Weight Training 19:58 Shifting Focus from Exercise to Movement 21:01 Exercise Snacks: Small, Frequent Movements 21:59 Setting Fun and Motivating Goals 23:04 Legacy and Influencing Younger Generations 23:53 Encouraging Women to Embrace Aging 24:58 Debra's Books and Programs 25:59 Closing Remarks Check us out on social media: theknewmethod.com/instagram theknewmethod.com/facebook theknewmethod.com/tiktok

BUFFALO, NY- April 1, 2024 – A new #research paper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 6, entitled, “Altered brain morphology and functional connectivity in postmenopausal women: automatic segmentation of whole-brain and thalamic subnuclei and resting-state fMRI.” The transition to menopause is associated with various physiological changes, including alterations in brain structure and function. However, menopause-related structural and functional changes are poorly understood. In this new study, researchers Gwang-Won Kim, Kwangsung Park, Yun-Hyeon Kim, and Gwang-Woo Jeong from Chonnam National University not only compared the brain volume changes between premenopausal and postmenopausal women, but also evaluated the functional connectivity between the targeted brain regions associated with structural atrophy in postmenopausal women. “To the best of our knowledge, no comparative neuroimaging study on alterations in the brain volume and functional connectivity, especially focusing on the thalamic subnuclei in premenopausal vs. postmenopausal women has been reported.” Each of the 21 premenopausal and postmenopausal women underwent magnetic resonance imaging (MRI). T1-weighted MRI and resting-state functional MRI data were used to compare the brain volume and seed-based functional connectivity, respectively. In statistical analysis, multivariate analysis of variance, with age and whole brain volume as covariates, was used to evaluate surface areas and subcortical volumes between the two groups. Postmenopausal women showed significantly smaller cortical surface, especially in the left medial orbitofrontal cortex (mOFC), right superior temporal cortex, and right lateral orbitofrontal cortex, compared to premenopausal women (p < 0.05, Bonferroni-corrected) as well as significantly decreased functional connectivity between the left mOFC and the right thalamus was observed (p < 0.005, Monte-Carlo corrected). Although postmenopausal women did not show volume atrophy in the right thalamus, the volume of the right pulvinar anterior, which is one of the distinguished thalamic subnuclei, was significantly decreased (p < 0.05, Bonferroni-corrected). “Postmenopausal women showed significantly lower left mOFC, right lOFC, and right STC surface areas, reduced right PuA volume, and decreased left mOFC-right thalamus functional connectivity compared to premenopausal women. If replicated in an independent sample, these findings will be helpful for understanding the effects of menopause on the altered brain volume and functional connectivity in postmenopausal women.” DOI - https://doi.org/10.18632/aging.205662 Corresponding author - Gwang-Woo Jeong - gwjeong@jnu.ac.kr About Aging-US Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer's diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases. Please visit our website at https://www.Aging-US.com​​. MEDIA@IMPACTJOURNALS.COM

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-373 Overview: In this episode, we review the effectiveness of intensive lifestyle intervention for type 2 diabetes mellitus (T2DM) remission. We unpack study findings on total diet replacement and consider its potential for improving weight loss and maintenance in patients. Tune in to enrich your clinical toolkit, empowering you to optimize patient outcomes and enhance quality of life. Episode resource links: Hocking, S. L., Markovic, T. P., Lee, C. M. Y., Picone, T. J., Gudorf, K. E., & Colagiuri, S. (2024). Intensive Lifestyle Intervention for Remission of Early Type 2 Diabetes in Primary Care in Australia: DiRECT-Aus. Diabetes care, 47(1), 66–70. https://doi.org/10.2337/dc23-0781   Centers for Disease Control:  Diabetes Care for Providers: https://www.cdc.gov/diabetes/professional-info/index.html   Optifast USA: https://www.optifast.com/   Pattinson, A. L., Seimon, R. V., Harper, C., Nassar, N., Grech, A., Santoso, E. A., Franklin, J., Inan-Eroglu, E., Gibson, A. A., & Sainsbury, A. (2021). Diet Quality following Total Meal Replacement Compared with Food-Based Weight-Loss Diets in Postmenopausal Women with Obesity: A Secondary Analysis of the TEMPO Diet Trial. The Journal of nutrition, 151(11), 3299–3312. https://doi.org/10.1093/jn/nxab311 Guest: Jill M. Terrien, PhD, ANP-BC    Music Credit: Richard Onorato

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-373 Overview: In this episode, we review the effectiveness of intensive lifestyle intervention for type 2 diabetes mellitus (T2DM) remission. We unpack study findings on total diet replacement and consider its potential for improving weight loss and maintenance in patients. Tune in to enrich your clinical toolkit, empowering you to optimize patient outcomes and enhance quality of life. Episode resource links: Hocking, S. L., Markovic, T. P., Lee, C. M. Y., Picone, T. J., Gudorf, K. E., & Colagiuri, S. (2024). Intensive Lifestyle Intervention for Remission of Early Type 2 Diabetes in Primary Care in Australia: DiRECT-Aus. Diabetes care, 47(1), 66–70. https://doi.org/10.2337/dc23-0781   Centers for Disease Control:  Diabetes Care for Providers: https://www.cdc.gov/diabetes/professional-info/index.html   Optifast USA: https://www.optifast.com/   Pattinson, A. L., Seimon, R. V., Harper, C., Nassar, N., Grech, A., Santoso, E. A., Franklin, J., Inan-Eroglu, E., Gibson, A. A., & Sainsbury, A. (2021). Diet Quality following Total Meal Replacement Compared with Food-Based Weight-Loss Diets in Postmenopausal Women with Obesity: A Secondary Analysis of the TEMPO Diet Trial. The Journal of nutrition, 151(11), 3299–3312. https://doi.org/10.1093/jn/nxab311 Guest: Jill M. Terrien, PhD, ANP-BC    Music Credit: Richard Onorato

We took some time to discuss this recent article which is very timely and it compared weight loss response and changes in cardiometabolic risk markers in postmenopausal women using semaglutide with and without menopause hormone therapy (HT) use. In postmenopausal women with overweight or obesity treated with semaglutide, HT use was associated with an improved weight loss response. It was a small study size of 60 women but nonetheless good data. Larger studies should be conducted to confirm these results.Article: https://pubmed.ncbi.nlm.nih.gov/38446869/To Follow US check out: Heather- www.theshowcenter.comJackie- https://www.mymonarchhealthco.comThe podcast- @justaskhiveHeather- @showcenterdrqJackie- @jackiep_gynnpTara @thesexualhealthpharmacistThe course is live and available at:the-hive8.teachable.com

The Journal of Rheumatology's Editor-in-Chief Earl Silverman discusses this month's selection of articles that are most relevant to the clinical rheumatologist. Elevated Serum Levels of Zonulin Family Peptides in Anticitrullinated Protein Antibody–Positive At-Risk Individuals Without Arthritis - doi.org/10.3899/jrheum.2023-0160 Use of the Bath Ankylosing Spondylitis Disease Activity Index in Patients With Psoriatic Arthritis With and Without Axial Disease - doi.org/10.3899/jrheum.2023-0504 Risk Factors and Incidence of Serious Infections in Patients With Systemic Lupus Erythematosus Undergoing Rituximab Therapy - doi.org/10.3899/jrheum.2023-0623 Psychiatric Morbidity Is Common Among Children With Juvenile Idiopathic Arthritis: A National Matched Cohort Study - doi.org/10.3899/jrheum.2023-0084 Plasma Cartilage Acidic Protein 1 Measured by ELISA Is Associated With the Progression to Total Joint Replacement in Postmenopausal Women - doi.org/10.3899/jrheum.2023-0684

Ever wondered how to support your partner through menopause? In this episode of The Fallible Man Podcast Kristin Mallon explains how the ups and downs of perimenopause and postmenopause can affect women. Lower estrogen levels can bring on a range of physical and emotional shifts, like trouble sleeping, mental fog, and body aches. Understanding these changes and being proactive about seeking help can really make a difference in how women handle this phase of life. It's not just about physical support, but being there emotionally and mentally too. We asked the questions you need to know. "If your woman in your life is between the ages of 35 to 60 and she's struggling with something, it could be hormonal, and I would just really encourage you to encourage her to get it checked out." - Kristin Mallon In this episode, you will be able to: Understand the impact of menopause on women's lives. Discover successful role models for navigating menopause. Support your partner through the challenges of menopause. Explore the hormonal changes experienced during menopause. Learn ways to maintain intimacy during the menopausal phase. My special guest is Kristin Mallon Kristin Mallon, a certified nurse midwife and co-founder/CEO of Femgevity Health, has garnered over 25 years of experience in women's health. Specializing in feminine longevity, she is dedicated to providing comprehensive telemedicine solutions and personalized treatment plans to support women in their 30s, 40s, and beyond. With a strong focus on optimizing women's health and lifespan during menopause, Kristin's expertise is rooted in her extensive background in private practice and her commitment to women's health. As a leading figure in the field, her wealth of experience and passion for women's health make her a credible source for understanding the challenges and offering support through menopause. The key moments in this episode are: 00:00:00 - Venturing into the Uncomfortable 00:01:08 - Introducing Kristen Mallon 00:03:22 - Defining Kristen Mallon 00:05:17 - Influential Women and Role Models 00:13:37 - Embracing Femininity 00:14:47 - Uncovering Personal Facts 00:19:39 - Diving into Menopause 00:20:34 - Kristen's Impressive Background 00:26:41 - Understanding Menopause 00:27:41 - Understanding Menopause 00:30:51 - Changes in Women's Lives 00:38:35 - Impact of Stress on Menopause 00:41:12 - Intimacy and Menopause 00:42:40 - Overlapping Issues in Postpartum and Perimenopause 00:43:34 - Impact of Hormonal Changes on Intimacy 00:46:30 - Supporting Women through Menopause 00:54:27 - Effective Communication Strategies 00:56:40 - The Role of Medical Specialists 00:56:52 - Seeking Menopause Specialists 00:59:26 - Supporting Intimacy During Menopause 01:05:52 - Mental Support for Postmenopausal Women 01:06:15 - Femgevity and Telemedicine   Guest Links: https://www.femgevityhealth.com/ https://www.facebook.com/FemGevity https://www.instagram.com/femgevity https://www.linkedin.com/company/femgevityhealth/ https://twitter.com/FemGevity    The video version of this show is available on YouTube after 3 PM the day it is released https://www.youtube.com/@thefalliblemanpodcast and Rumble! https://rumble.com/c/c-2176422   Join our Exclusive Private Community – Fallible Nation https://bit.ly/FallibleNation   Sponsors: Grow YOUR Show: The Easy Button for Podcasters Have you thought about starting a podcast to grow your business or even as a hobby? Then you need to go talk to my friend Adam Adams. I trust him and so you should you! https://growyourshow.com/ Ghost Bed Actually get a GOOD night's sleep! Go see my friends at https://www.ghostbed.com/pages/fallible and use the code “fallible” for 30% off your order! It's what I sleep on and what I count on!

Dr. Samantha Cote discusses her paper, "Association of Cumulative Lifetime Exposure to Female Hormones With Cerebral Small Vessel Disease in Postmenopausal Women in the UK Biobank". Show references: https://n.neurology.org/content/early/2023/09/27/WNL.0000000000207845

Menopause (Episode 91, To Your Health with Dr. Jim Morrow) Host Dr. Jim Morrow addressed the topic of menopause on this episode of To Your Health. He clarified what qualifies as menopause, how it’s diagnosed, the range of symptoms, potential treatments such as hormone replacement therapy, the impact on sleep, bone health, heart health, and more. […] The post Menopause appeared first on Business RadioX ®.

Weight loss is in the spotlight, thanks to the popularity of Ozempic and other medications that help people lose weight. But . . . there are more ways than this to get to your personal healthy weight.  In this enlightening episode of GRUFFtalk: How to Age Better Podcast, host Barbara Hannah Grufferman sits down with Rachel Smith, an expert on obesity, longevity, and women's health and wellness. Together, they delve into the specific challenges and opportunities facing postmenopausal women in their quest to achieve a personal healthy weight.  The conversation centers around four essential pillars:  1. What to Eat: Rachel guides us through the nuanced dietary needs of postmenopausal women, explaining how proper nutrition – with an emphasis on protein -- can bolster health and wellness at this stage of life.  2. How to Move: Exercise is essential for vitality and weight management. Barbara and Rachel discuss optimal exercise routines and activities that are both effective and sustainable for postmenopausal women.  3. What's Your Emotional Connection to Food: An in-depth exploration into how emotions influence eating habits is discussed. Rachel talks through strategies for recognizing and addressing emotional triggers, fostering a healthier relationship with food.  4. Medications that Help Weight Loss: The conversation highlights specific medications, such as Ozempic, that can aid in weight loss. Rachel offers insights into how these medications work and how they can be part of a comprehensive weight management strategy for some people.  Together, Barbara and Rachel weave these four pillars into an empowering narrative, sprinkled with personal insights, cultural considerations, and the latest research. They emphasize a holistic approach, blending the science of weight management with the personal experience of postmenopausal women.  Whether you're facing this transition yourself, supporting a loved one, or simply seeking to understand more about this significant phase of women's lives, this episode is a must-listen.   KEY LINKS:  Learn more about Rachel Smith and her work at Discover Health: https://www.discovermyhealth.com  Tabata vs HIIT—What's the Difference?: https://health.clevelandclinic.org/tabata-vs-hiit-whats-the-difference/  Rachel Smith's Article on Intermittent Fasting: https://www.healio.com/news/primary-care/20230713/a-look-at-intermittent-fasting-a-potential-strategy-for-patients-with-obesity  Earlier Episode of GRUFFtalk Focusing on ‘Protein Timing': https://podcasts.apple.com/us/podcast/grufftalk-how-to-age-better-with-barbara-hannah-grufferman/id1623436268?i=1000603125207  The Whole Body Reset: https://www.amazon.com/Whole-Body-Reset-Weight-Loss-Optimum/dp/1982160128  The Importance of Protein for Postmenopausal Women: https://www.fitnessinmenopause.com/blog/menopause-menu-protein-and-menopause  What is Ozempic? https://health.ucdavis.edu/blog/cultivating-health/ozempic-for-weight-loss-does-it-work-and-what-do-experts-recommend/2023/07  Connect with Barbara:  Website: https://www.barbarahannahgrufferman.com   Facebook: https://www.facebook.com/BarbaraHannahGruffermanAuthor  Instagram: https://www.instagram.com/barbarahannahgrufferman/  Learn more about your ad choices. Visit megaphone.fm/adchoices

Lege Sjur Even Aunmo er opptatt av å følge med på forskning. I denne episoden forteller han om problemene med å leve av planter. Planter har nemlig forsvarsmekanismer mot å bli spist. De kan dessuten stjele mineraler, trigge immunsystemet, tilføre tungmetall og gi næring til kreft. Selv foretrekker han et kosthold bestående utelukkende av animalske produkter. Han synes det er beklagelig at rådene har blitt politiske gjennom at de har tatt inn klimasaken, fremfor at de er en mest mulig sann fremstilling av hva ulike typer mat gjør med kroppen. Aunmo legger frem forskningsevidens som peker i motsatt retning av kostholdsrådene norske myndigheter har lagt frem nylig. Han har mange suksesshistorier fra pasienter med autoimmune sykdommer, diabetes og andre sykdommer, som har blitt friske etter at de sluttet å spise bestemte typer planter, produkter fra planter eller utelukket dem helt fra kosten.Sjur Even Aunmo: • youtube.com • facebook.comGrønnsaker uten noen kjent form for gluten: • hodekål, blomkål, brokkoli, paprika, rødbeter, bladbete, squash, potet, søtpotet, gulrøtter, gresskar, romano-salat, indisk bladsennep, spinat, grønnkål • Obs: Selv om disse plantene ikke inneholder gluten, finnes det andre stoffer i dem som er uheldige. Paprika, for eksempel, hører til søtvier-familien, sammen med potet og tobakk. De forsvarer seg mot mennesker, dyr og insekter med lektiner og solanin. Spinat inneholder mye oksalat som stjeler kalsium fra kroppen. Det finnes igjen i nyrestener og mistenkes for å stimulere brystkreft. Grønnsaker inneholder druesukker, som er et viktig næringsstoff for kreft. Grønnsaker som vokser over bakken inneholder ofte mindre sukker enn de som vokser under bakken. De minst usunne grønnsakene på listen synes å være hodekål, blomkål og brokkoli, på tross av at disse danner goitrin, et stoff som motvirker dannelsen av stoffskiftehormon.Diverse kilder: • Mindre kjøtt, mer plantebasert: Her kommer De nordiske ernæringsanbefalingene 2023 • Helsedirektoratets kostråd • The Seven Countries Study (søk) • Paleo diet (søk) • Keto diet (søk) • Carnivore diet (søk)› Relaterte AJP-episoder: • AJP 61 | Sjur Even Aunmo – Fikk sparken for å snakke om bivirkningerRelatert forskning:› FETT› https://doi.org/10.1136/bmj.e8707 Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis› https://doi.org/10.1136/bmj.i1246 Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73)› https://doi.org/10.3945/ajcn.2009.27725 Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease› https://doi.org/10.1186/s12937-017-0254-5 The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials› https://doi.org/10.1016/j.jacc.2020.05.077 Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review› http://dx.doi.org/10.1136/openhrt-2014-000196 Evidence from randomised controlled trials did not support the introduction of dietary fat guidelines in 1977 and 1983: a systematic review and meta-analysis› http://dx.doi.org/10.1136/bmjebm-2019-111180 Fat or fiction: the diet-heart hypothesis› https://www.mn.uio.no/ibv/tjenester/kunnskap/plantefys/leksikon/h/herdet-fett.html› https://doi.org/10.1046/j.1471-4159.1997.68052092.x 4-Hydroxynonenal-Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease› https://doi.org/10.1016/j.freeradbiomed.2006.07.021 Induction of mitochondrial nitrative damage and cardiac dysfunction by chronic provision of dietary ω-6 polyunsaturated fatty acids› https://doi.org/10.1038/s41467-018-05614-6 Dietary stearic acid regulates mitochondria in vivo in humans› http://dx.doi.org/10.17140/AFTNSOJ-1-123 Oxidation of Polyunsaturated Fatty Acids and its Impact on Food Quality and Human Health› https://doi.org/10.1194/jlr.M026179 Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells› https://doi.org/10.1021/jf049207s Effect of the Type of Frying Culinary Fat on Volatile Compounds Isolated in Fried Pork Loin Chops by Using SPME-GC-MS› STATINER (KOLESTEROLSENKENDE STOFFER)› http://dx.doi.org/10.1136/bmjopen-2018-023085 Statins for the primary prevention of cardiovascular disease: an overview of systematic reviews› http://dx.doi.org/10.1136/bmjopen-2014-007118 The effect of statins on average survival in randomised trials, an analysis of end point postponement› https://doi.org/10.1001/archinternmed.2010.182 Statins and All-Cause Mortality in High-Risk Primary Prevention: A Meta-analysis of 11 Randomized Controlled Trials Involving 65 229 Participants› https://www.felleskatalogen.no/medisin/lipitor-upjohn-eesv-pfizer-560999› https://www.felleskatalogen.no/medisin/zocor-organon-565655› https://www.legemiddelhandboka.no/L8.15.1/Statiner› https://www.bmj.com/campaign/statins-open-data Statins - a call for transparent data› https://doi.org/10.1001/archinternmed.2011.625 Statin Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women's Health Initiative› https://doi.org/10.1007/s40264-017-0620-4 Amyotrophic Lateral Sclerosis Associated with Statin Use: A Disproportionality Analysis of the FDA's Adverse Event Reporting System› https://doi.org/10.1001/jamainternmed.2020.6084 Evaluation of Time to Benefit of Statins for the Primary Prevention of Cardiovascular Events in Adults Aged 50 to 75 Years› https://doi.org/10.1016/j.atherosclerosis.2022.07.003 Statin therapy for the primary prevention of cardiovascular disease: Cons› http://doi.org/10.1161/STROKEAHA.121.034576 Lipid-Lowering Therapy and Hemorrhagic Stroke RiskLipid-Lowering Therapy and Hemorrhagic Stroke Risk› KJØTT› https://www.acpjournals.org/doi/full/10.7326/M19-0622 Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes A Systematic Review of Randomized Trials› https://doi.org/10.3945/ajcn.116.142521 Total red meat intake of ≥0.5 servings/d does not negatively influence cardiovascular disease risk factors: a systemically searched meta-analysis of randomized controlled trials› https://doi.org/10.3945/ajcn.113.062638 Meat intake and cause-specific mortality: a pooled analysis of Asian prospective cohort studies› FISK› https://doi.org/10.1093/jn/nxab112 Biomarkers and Fatty Fish Intake: A Randomized Controlled Trial in Norwegian Preschool Children› https://doi.org/10.1007/s12016-013-8363-1 Fish Allergy: In Review› KOLESTEROL› http://dx.doi.org/10.1136/bmjopen-2015-010401 Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review› https://doi.org/10.1016/j.mehy.2018.09.019 Inborn coagulation factors are more important cardiovascular risk factors than high LDL-cholesterol in familial hypercholesterolemia› PMID: 18277343 ApoB/ApoA1 ratio and subclinical atherosclerosis› https://doi.org/10.1016/0021-9150(89)90130-5 Cigarette smoking renders LDL susceptible to peroxidative modification and enhanced metabolism by macrophages› https://doi.org/10.1161/01.CIR.93.7.1346 Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia: Role of Oxidized LDL› https://doi.org/10.1161/01.CIR.97.20.2012 Passive Smoking Induces Atherogenic Changes in Low-Density Lipoprotein› https://doi.org/10.1016/j.atherosclerosis.2008.04.046 Smoking and smoking cessation—The relationship between cardiovascular disease and lipoprotein metabolism: A review› https://doi.org/10.1161/ATVBAHA.113.300156 Smoking and Cardiovascular Disease› https://doi.org/10.3402/fnr.v59.29240 LDL biochemical modifications: a link between atherosclerosis and aging› https://doi.org/10.1016/j.cjca.2017.07.015 Association Between Circulating Oxidized LDL and Atherosclerotic Cardiovascular Disease: A Meta-analysis of Observational Studies› https://doi.org/10.1054/plef.2000.0204 Why is glycated LDL more sensitive to oxidation than native LDL? A comparative study.› KARBOHYDRAT› https://www.helsedirektoratet.no/rapporter/anbefalinger-om-kosthold-ernaering-og-fysisk-aktivitet/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf/_/attachment/inline/2f5d80b2-e0f7-4071-a2e5-3b080f99d37d:2aed64b5b986acd14764b3aa7fba3f3c48547d2d/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf› FRUKTOSE› https://doi.org/10.1016/j.jhep.2021.02.027 Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial› https://doi.org/10.1093/ajcn/nqaa332 Effects of fructose restriction on liver steatosis (FRUITLESS); a double-blind randomized controlled trial› https://doi.org/10.5223/pghn.2021.24.5.483 The Relationship between Daily Fructose Consumption and Oxidized Low-Density Lipoprotein and Low-Density Lipoprotein Particle Size in Children with Obesity› KUNSTIG SØTNING› https://doi.org/10.1016/s0378-8741(99)00081-1 Effects of chronic administration of Stevia rebaudiana on fertility in rats› https://doi.org/10.1371/journal.pone.0000698 Intense Sweetness Surpasses Cocaine Reward› https://doi.org/10.1016/j.cell.2022.07.016 Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance› https://doi.org/10.1289/ehp.8711 First Experimental Demonstration of the Multipotential Carcinogenic Effects of Aspartame Administered in the Feed to Sprague-Dawley Rats› https://doi.org/10.1289/ehp.10271 Life-Span Exposure to Low Doses of Aspartame Beginning during Prenatal Life Increases Cancer Effects in Rats› DIABETES› https://doi.org/10.1001/jama.295.6.655 Low-Fat Dietary Pattern and Risk of Cardiovascular DiseaseThe Women's Health Initiative Randomized Controlled Dietary Modification Trial – se side 661, økt hjerte/kar-risk sfa. Lavfett-diett› https://doi.org/10.3945/ajcn.110.010843 Effects of a low-fat dietary intervention on glucose, insulin, and insulin resistance in the Women's Health Initiative (WHI) Dietary Modification trial› https://doi.org/10.1007/s11745-008-3274-2 AOCS Lipids (lavranket journal) Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet› https://doi.org/10.1161/ATVBAHA.114.303284 Small Dense Low-Density Lipoprotein-Cholesterol Concentrations Predict Risk for Coronary Heart Disease- ArtThromVas prospektiv kohort› https://doi.org/10.1097/MOL.0b013e328306a057 Glycation as an atherogenic modification of LDL : Current Opinion in Lipidology› https://doi.org/10.1016/0021-9150(93)90084-8 Glycosylated low density lipoprotein is more sensitive to oxidation: implications for the diabetic patient?› https://doi.org/10.2337/diabetes.55.02.06.db05-1103 Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo› https://doi.org/10.1016/S0895-7061(00)01260-7 Blood viscosity and blood pressure: role of temperature and hyperglycemia› https://doi.org/10.2337/dc13-1374 Blood Viscosity in Subjects With Normoglycemia and Prediabetes› https://doi.org/10.1007/s00592-017-1004-z Elevated 1-h post-challenge plasma glucose levels in subjects with normal glucose tolerance or impaired glucose tolerance are associated with whole blood viscosity› https://doi.org/10.1080/09674845.2010.11730293 Blood viscosity at different stages of diabetes pathogenesis.› DIABETES-DEMENS› https://doi.org/10.1212/WNL.53.9.1937 Diabetes mellitus and the risk of dementia - The Rotterdam Study› https://doi.org/10.1016/S1474-4422(05)70284-2 Lancet Neurology 2006, sysrew lavere evidensgrad. Risk of dementia in diabetes mellitus: a systematic review› https://doi.org/10.1111/j.1445-5994.2012.02758.x Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies› https://doi.org/10.1016/j.arr.2019.100944 Diabetes mellitus and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 144 prospective studies› https://doi.org/10.1177/193229680800200619 Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed› https://doi.org/10.3390/ijerph120708281 Evaluating the Association between Diabetes, Cognitive Decline and Dementia› https://doi.org/10.3390/ijms21030934 Ketone Bodies Promote Amyloid-β1–40 Clearance in a Human in Vitro Blood–Brain Barrier Model› https://doi.org/10.1038/s41574-018-0048-7 Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications› https://doi.org/10.1038/s41586-020-2247-3 APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline› DIABETES NYRESYKDOM› https://doi.org/10.2337/diacare.27.2007.S79 Nephropathy-in-Diabetes Nephropathy in Diabetes› Diabetic Nephropathy: Diagnosis, Prevention, and Treatment› https://doi.org/10.1016/S0272-6386(96)90538-7 Diabetic nephropathy in type II diabetes› DIABETES ØYESYKDOM› https://doi.org/10.1016/S0140-6736(09)62124-3 Diabetic retinopathy› https://doi.org/10.1016/S2213-8587(18)30128-1 Incidence and progression of diabetic retinopathy: a systematic review› DIABETES HJERTE- OG KAR-SYKDOM› https://doi.org/10.1001/jamacardio.2020.7073 Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident Coronary Heart Disease in Women› PLANTE-ANTINÆRINGSSTOFF, VERN OG GIFT› https://doi.org/10.1016/j.foodchem.2008.01.056 Food Chemistry 2008 Bioaccessibility of Ca, Mg, Mn and Cu from whole grain tea-biscuits: Impact of proteins, phytic acid and polyphenols› https://doi.org/10.1002/mnfr.200900099 Phytate in foods and significance for humans: food sources, intake, processing, bioavailability, protective role and analysis.› https://doi.org/10.1046/j.1440-6047.1999.00038.x Oxalate content of foods and its effect on humans› https://doi.org/10.1104/pp.109.2.347 Lectins as plant defense proteins.› https://doi.org/10.1016/j.taap.2009.03.012 Effects of wheat germ agglutinin on human gastrointestinal epithelium: Insights from an experimental model of immune/epithelial cell interaction› https://doi.org/10.1038/s41531-018-0066-0 Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat› https://doi.org/10.1016/S0140-6736(05)79894-9 Identification of intact peanut lectin in peripheral venous blood› https://doi.org/10.1136/bmj.318.7190.1023 Do dietary lectins cause disease?› https://doi.org/10.1016/S0015-0282(16)54596-8 Lectin binding of endometrium in women with unexplained infertility› https://doi.org/10.1016/S0271-5317(88)80133-7 Changes in organs and tissues induced by feeding of purified kidney bean (Phaseolus vulgaris) lectins› https://doi.org/10.3390/molecules20022014 Insecticidal Activity of Plant Lectins and Potential Application in Crop Protection› https://doi.org/10.1210/endo-113-6-1921 Bound Lectins that Mimic Insulin Produce Persistent Insulin-Like Activities› https://doi.org/10.1042/BJ20071137 Contribution of leptin receptor N-linked glycans to leptin binding› https://doi.org/10.1111/j.1365-2249.2007.03368.x Potato lectin activates basophils and mast cells of atopic subjects by its interaction with core chitobiose of cell-bound non-specific immunoglobulin E› https://doi.org/10.1002/(SICI)1521-4141(199903)29:03 Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils› https://doi.org/10.1016/j.ekir.2018.07.020 Secondary Oxalate Nephropathy: A Systematic Review› http://dx.doi.org/10.1136/gut.16.3.193 The effect of tea on iron absorption.› PMID: 1862 Disler PB, Lynch SR, Torrance JD, et al. The mechanism of the inhibition of iron absorption by tea. The South African Journal of Medical Sciences. 1975 ;40(4):109-116.› https://doi.org/10.1016/0887-2333(95)00113-1 Effects of saponins and glycoalkaloids on the permeability and viability of mammalian intestinal cells and on the integrity of tissue preparationsin vitro› https://doi.org/10.1079/BJN2002725 The biological action of saponins in animal systems: a review› http://doi.org/10.1093/carcin/bgp082 Lung tumor promotion by curcumin› https://doi.org/10.3945/ajcn.2009.26736M Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford)› https://doi.org/10.3382/ps.0550716 Antithyroid Activity of Goitrin in Chicks› https://doi.org/10.1016/s0278-6915(82)80294-9 Hepatic effects of R-goitrin in in Sprague-Dawley rats› https://doi.org/10.1002/ana.24448 Vagotomy and subsequent risk of Parkinson's disease --> https://doi.org/10.1038/s41531-018-0066-0› Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat› http://doi.org/10.1056/NEJMra2010852 Salicylate Toxicity› https://doi.org/10.1021/jf0113070 Relationship between Cyanogenic Compounds in Kernels, Leaves, and Roots of Sweet and Bitter Kernelled Almonds› https://doi.org/10.1179/146532810X12637745451951Cyanide poisoning caused by ingestion of apricot seeds› https://doi.org/10.3390/toxins11060324 Ricin: An Ancient Story for a Timeless Plant Toxin› https://doi.org/10.1016/j.taap.2009.03.012Effects of wheat germ agglutinin on human gastrointestinal epithelium: Insights from an experimental model of immune/epithelial cell interaction› GLUTEN› https://doi.org/10.1080/00365520500235334 Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines› https://doi.org/10.1053/j.gastro.2008.03.023 Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3› https://doi.org/10.1016/j.jprot.2017.03.026 A curated gluten protein sequence database to support development of proteomics methods for determination of gluten in gluten-free foods› https://doi.org/10.1111/jgh.13703 What is gluten?› https://doi.org/10.1186/s41043-015-0032-y The opioid effects of gluten exorphins: asymptomatic celiac disease› https://doi.org/10.1016/j.peptides.2015.07.013 Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects› SOYA› https://doi.org/10.1271/bbb.70516Soymorphins, novel μ opioid peptides derived from soy β-conglycinin β-subunit, have anxiolytic activities.› TILSETNINGSSTOFFER› https://doi.org/10.3233/NHA-170023 A randomized trial of the effects of the no-carrageenan diet on ulcerative colitis disease activity› https://doi.org/10.1053/j.gastro.2021.11.006 Randomized Controlled-Feeding Study of Dietary Emulsifier Carboxymethylcellulose Reveals Detrimental Impacts on the Gut Microbiota and Metabolome› https://doi.org/10.1002/ijc.21925 Processed meat consumption, dietary nitrosamines and stomach cancer risk in a cohort of Swedish women› KETOGENISITET/KREFT› https://oslo-universitetssykehus.no/behandlinger/pet-undersokelse› https://stanfordhealthcare.org/medical-tests/p/pet-scan/what-to-expect.html› https://www.sciencedirect.com/topics/medicine-and-dentistry/warburg-effect› https://doi.org/10.1016/j.tibs.2015.12.001 The Warburg Effect: How Does it Benefit Cancer Cells?› https://doi.org/10.1080/01635581.2019.1650942 Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study› https://doi.org/10.1093/jnci/djs399 Dietary Glycemic Load and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings From CALGB 89803› https://doi.org/10.18632/aging.101382 Ketogenic diet in cancer therapy› IATROGENISITET› https://doi.org/10.1111/eci.12834 How to survive the medical misinformation mess› https://doi.org/10.1111/jlme.12068 Institutional Corruption of Pharmaceuticals and the Myth of Safe and Effective Drugs› https://doi.org/10.1136/bmj.f3830 Why we can't trust clinical guidelines› https://doi.org/10.1016/S0140-6736(15)60696-1 Offline: What is medicine's 5 sigma?› https://apjcn.nhri.org.tw/server/apjcn/procnutsoc/1990-1999/1995/1995%20p1-10.pdfLast ned episodenInnspilt: 2023-07-18Publisert: 2023-07-28Støtte Antijantepodden?Liker du arbeidet vi gjør, og vil bidra til at vi lager flere episoder?Finn ut hvordan du kan gi noe tilbake ved å gå til antijantepodden.com!Meld deg på vårt nyhetsbrev

Listener feedback, conduction system pacing, eating fish vs fish pills, exercise, and an RCT for diet are the topics discussed by John Mandrola,.MD, in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. Listener Feedback Monitor HF and AHA Jun 02, 2023 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/992678 - Link to the ACC Email -- https://www.acc.org/Latest-in-Cardiology/Clinical-Trials/2023/07/18/17/21/monitor-hf - Tweet From Anthony Pearson https://twitter.com/skepcard/status/1681288604990189574 II. Conduction System Pacing - Clinical Outcomes in Conduction System Pacing Compared to Right Ventricular Pacing in Bradycardia https://doi.org/10.1016/j.jacep.2022.10.016 - Hormone Therapy To Prevent Disease and Prolong Life in Postmenopausal Women https://www.acpjournals.org/doi/abs/10.7326/0003-4819-117-12-1016 III. Fish Oil Omega-3s and AF: No Added Risk From Eating Fish but High-Dose Supplement Questions Persist https://www.medscape.com/viewarticle/994559 - Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation https://www.jacc.org/doi/full/10.1016/j.jacc.2023.05.024 - Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia https://www.nejm.org/doi/full/10.1056/nejmoa1812792 - Effect of Long-Term Marine ɷ-3 Fatty Acids Supplementation on the Risk of Atrial Fibrillation in Randomized Controlled Trials of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.055654 IV. Exercise Even Exercise by 'Weekend Warriors' Can Cut CV Risk https://www.medscape.com/viewarticle/994617 - Accelerometer-Derived “Weekend Warrior” Physical Activity and Incident Cardiovascular Disease https://jamanetwork.com/journals/jama/article-abstract/2807286 V. Diet Cognitive Benefit of Highly Touted MIND Diet Questioned https://www.medscape.com/viewarticle/994550 - Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons https://www.nejm.org/doi/full/10.1056/NEJMoa2302368 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Join Nurse Doza as he delves into the complex world of acne, a condition affecting millions worldwide. This episode will enlighten listeners about the various factors that contribute to acne, including hormonal fluctuations, dietary influences, lifestyle habits, and more. Nurse Doza brings his wealth of experience in treating patients with acne and emphasizes the significance of addressing acne's root causes for truly effective, long-lasting solutions.   Timestamps: 00:00 - Introduction 01:14 - Defining Acne: An Overview 05:20 - Root Cause 1: Inflammation and Acne 10:16 - Root Cause 2: Bacterial Overgrowth and Acne 15:24 - Root Cause 3: Hormonal Imbalance and Acne 21:13 - Root Cause 4: Dietary Influence and Acne 25:42 - Root Cause 5: Impact of Certain Medications on Acne 30:57 - Wrap-up and Final Thoughts Unleash Your Skin's Potential with MSW Nutrition's Liver Love Take control of your acne with MSW Nutrition's Liver Love, a formulation designed to support optimal liver health and hormone balance. By addressing the root causes of acne, Liver Love can help you achieve healthier, clearer skin. Shop MSW Liver Love Here and start your journey to healthier skin today.   SHOW NOTES: Delve deeper into the intricacies of acne with the below topics discussed during the episode: 1. Understanding Acne: The Basics - A look at what acne is and how it forms. 2. Inflammation: A Key Culprit in Acne - How inflammation can contribute to acne and potential solutions. 3. Bacterial Overgrowth: An Unseen Enemy** - Examining the impact of bacterial overgrowth on acne and potential remedies. 4. **Hormonal Imbalance: A Silent Trigger** - The link between hormonal imbalances and acne, and how to counteract it. 5. **Food Sensitivity: An Unexplored Factor** - Discussing how certain foods can potentially trigger acne. 6. **Medications: A Double-Edged Sword** - Analyzing how certain medications can lead to acne breakouts. 7. **Liver Health: The Unsung Hero** - The critical role liver health plays in maintaining hormonal balance and healthy skin, and how Liver Love can provide the needed support. REFERENCES: Understanding Acne: The Basics - National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). Inflammation: A Key Culprit in Acne - Recent advances in understanding Propionibacterium acnes (Cutibacterium acnes) in acne, NCBI. Bacterial Overgrowth: An Unseen Enemy - How is folliculitis related to acne?, LearnSkin, Folliculitis: Symptoms and Causes, Mayo Clinic, and Recent advances in understanding Propionibacterium acnes (Cutibacterium acnes) in acne, NCBI. Hormonal Imbalance: A Silent Trigger - The Role of Estrogen in Acne, Acne.org, Conversion of estrone to estradiol and estradiol to estrone in postmenopausal women, PubMed, and Influence of Age and Obesity on Serum Estradiol, Estrone, and Sex Hormone Binding Globulin Concentrations following Oral Estrogen Administration in Postmenopausal Women, NCBI. Food Sensitivity: An Unexplored Factor - Milk consumption and acne in teenaged boys, NCBI, Acne and Gut Health, Weston A Price Foundation, and Milk consumption and acne in adolescent girls, PubMed. Medications: A Double-Edged Sword - What medications can cause acne?, Acne.org.  

Interview with Alison J. Huang, MD, MAS, and Deborah Grady, MD, MPH, authors of Efficacy of Continuous Transdermal Nitroglycerin for Treating Hot Flashes by Inducing Nitrate Cross-tolerance in Perimenopausal and Postmenopausal Women: A Randomized Clinical Trial. Hosted by Carolyn Crandall, MD. Related Content: Efficacy of Continuous Transdermal Nitroglycerin for Treating Hot Flashes by Inducing Nitrate Cross-tolerance in Perimenopausal and Postmenopausal Women

Interview with Alison J. Huang, MD, MAS, and Deborah Grady, MD, MPH, authors of Efficacy of Continuous Transdermal Nitroglycerin for Treating Hot Flashes by Inducing Nitrate Cross-tolerance in Perimenopausal and Postmenopausal Women: A Randomized Clinical Trial. Hosted by Carolyn Crandall, MD. Related Content: Efficacy of Continuous Transdermal Nitroglycerin for Treating Hot Flashes by Inducing Nitrate Cross-tolerance in Perimenopausal and Postmenopausal Women

CME credits: 1.00 Valid until: 01-05-2024 Claim your CME credit at https://reachmd.com/programs/cme/id-and-ida-in-postmenopausal-women/15133/ This series of bite-sized episodes contains important information you need to know about iron deficiency and iron deficiency anemia in your female patients. Dr. Malcolm Munro and colleagues discuss recent evidence and provide practical approaches for screening, diagnosing, treating, and preventing the progression of this condition.

Rochelle Waite has a different take on supporting women through the perimenopausal period. Instead of reaching first for "women's herbs", Rochelle instead goes back to grass roots Naturopathic principles. With Masters in Immunology, Reproductive Medicine and Women's Health Medicine she is perfectly placed to make practical recommendations to maintain her patients' enjoyment of life as they transition through perimenopause.Her reasoning? If cells aren't properly nourished then organs can't function efficiently, and if they don't work then herbs which ostensibly work on those organs could be thwarted.Working with basic nutrition and digestive enhancement, Rochelle brings about rejuvenation from the ground up to avoid unnecessary supplementation and hence improved compliance from her common sense approach.URL: https://rochellewaitenaturopath.com/ FB: https://www.facebook.com/rochellewaitenaturopath/References: Kanat M, Sipahioglu M, Arinc H, et al. Is lipid lowering treatment aiming for very low LDL levels safe in terms of the synthesis of steroid hormones? Med Hypotheses. 2007;69(1):104-12. Epub 2007 Jan 17. DOI: 10.1016/j.mehy.2006.10.058Schade DS, Shey L, Eaton RP. Cholesterol Review: A Metabolically Important Molecule. Endocr Pract. 2020 Dec;26(12):1514-1523. DOI: 10.4158/EP-2020-0347Hu J, Zhang Z, Shen WJ, et al. Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones. Nutr Metab (Lond). 2010;7:47. DOI: 10.1186/1743-7075-7-47Reid R, Abramson BL, Blake J, et al. Menopause and Osteoporosis Working Group. Managing Menopause. SOGC Clinical Practice Guideline. J Obstet Gynaecol Can. 2014 Sep;36(9):830-833. DOI: 10.1016/S1701-2163(15)30487-4Silva TR, Oppermann K, Reis FM, et al. Nutrition in Menopausal Women: A Narrative Review. Nutrients. 2021 Jul;13(7): 2149. DOI: 10.3390/nu13072149Medical & Health Articles. Foods for Menopause. Jean Hailes For Women's Health. 2023. (Accessed 2023 Mar 13). https://www.jeanhailes.org.au/news/foods-for-menopausePeters BA, Santoro N, Kaplan RC, et al. Spotlight on the Gut Microbiome in Menopause: Current Insights. Int J Womens Health. 2022;14:1059–1072. DOI: 10.2147/IJWH.S340491Lowe NM, Lowe NM, Fraser WD, Jackson MJ. Is there a potential therapeutic value of copper and zinc for osteoporosis? Proc Nutr Soc. 2002 May;61(2):181-5. DOI: 10.1079/PNS2002154Ciappolino V, Mazzocchi A, Enrico P, et al. N-3 Polyunsatured Fatty Acids in Menopausal Transition: A Systematic Review of Depressive and Cognitive Disorders with Accompanying Vasomotor Symptoms. Int J Mol Sci. 2018 Jun 23;19(7):1849. DOI: 10.3390/ijms19071849Ko SH, Kim HS. Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women. Nutrients. 2020 Jan 13;12(1):202. DOI: 10.3390/nu12010202Wong RH, Thaung Zaw JJ, Xian CJ, Howe PR. Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial. J Bone Miner Res. 2020 Nov;35(11):2121-2131. DOI: 10.1002/jbmr.4115

Is it too late to gain lean muscle in menopause? No. Is it harder to gain lean muscle in menopause? Than it was when you were at your peak muscle in your 20s, yes. Shouldn't I focus on fat loss first? No.  To gain lean muscle … so you look better, feel better, and do life better there are some things you need. You'll need to understand the balance between the right exercise, the right recovery, the right total calories and total protein and the type and timing of exercise and protein during menopause.  Women get nutrition wrong. Most often if they'll do the exercise, they get hooked. But the exercise alone is going to take you only so far. As you'll hear more this year, if we consider strength training, protein, or supplements, the greatest of these is strength training.  You've got to lift. AND if you want it all as so many of us do, you need to integrate the work, recovery, and nutrition. There are thresholds for many of these. They don't call it exercise prescription for nothing. The protein and the exercise both have a dose-response component.  In this Episode:  What Exercise it Takes to Gain Lean Muscle What protein it Takes to Gain Lean Muscle  Overall Calorie Truths that Favor Lean Muscle  Questions I'll answer:  What strength training protocols actually work?  How important is protein in the more muscle-less fat equation? What is the importance and difference between Essential Amino Acids, BCAA, and leucine?  Could you be eating too little to gain lean muscle even if you're lifting?  Science:  Studying a group of postmenopausal women who had not been strength training at least 24 weeks prior, researchers showed that twice weekly strength training for 8 weeks [even with a higher repetition range than traditionally associated with strength] increased (Grzyb et al, 2022): Lean muscle mass muscle strength  muscle endurance The twice weekly protocol is advantageous for menopausal women because the need for honoring cortisol and adrenal health during a time when women are more vulnerable to the negative effects of stress. Without adequate recovery time, breakdown of muscle is significant enough during exercise (combined with lack of sleep, stress, low energy diet) that lean muscle gains would likely be lower with greater frequency of exercise. To prove there were no dietary changes, subjects submitted 3-day diet intakes before and after the study to confirm no dietary changes occurred.  Muscle Protein Synthesis and Muscle Protein Breakdown Muscle protein synthesis slows down after a meal so it's wise to consider regular meals and a possible snack of a post-workout smoothie to boost protein intake. Try getting four high protein meals to help you achieve adequate protein. Hit 30 grams at least at each meal. If you can consume more, the increased need in older adults has been proven. It takes a 70yr old man consuming 40 grams of protein post workout to achieve the same muscle protein synthesis as a 20yr old man.  Try these options to increase your protein intake.  Example 1: a pre-workout simple shake  post workout smoothie or protein-rich breakfast Lunch  Dinner  Example 2: Breakfast smoothie  Lunch Mid-afternoon smoothie Dinner  Should You Supplement? The amino acid leucine is particularly important. However, I don't suggest jumping to BCAA supplements. If your diet isn't adequate you can't out-supplement a diet poor in protein. I recommend if you're not consuming a diet rich in all 9 essential amino acids, you start with EAA supplementation first. (My recommendation is in flippingfifty.com/resources) Getting about 5 gm of leucine per day – if you've got two meals with six ounces each of turkey, beef, salmon, cod or tuna, you'll hit that.  Previously, I've shared American College of Sports Medicine's recommendations that before or after workout supplementation are both beneficial. Doing both if you eat a high-quality adequate calorie, adequate protein diet may not be “more” helpful.  However, if you're a hard-gainer or older, the ACSM review of literature did recommend both may be helpful.  Are You In Too Big a Calorie Deficit to Gain Muscle and Lose Fat?  During periods of excessive dieting and low calorie intake, the body favors protein breakdown. Yes, you heard right. Fasting and lifting may backfire. It's not helpful for midlife and older women who want to gain lean muscle, strength, and optimize body composition.  Signs it's happening for you?  You're tired all the time. You don't recover from workouts very quickly.  There's no desire to exercise.  Your mood and sleep are both meh.  Calorie In a calorie surplus with adequate protein dosed throughout the day, you will much more easily gain lean muscle. During this time, you may not be shredded. However, that term is really best reserved to those bodybuilders dieting down (unhealthfully) to reach a stage weight (and then all too often binge on a Big Mac afterwards).  You can shift periodically to a lower calorie diet, alternating the surplus with keeping it even. Note that you can gain strength with a calorie deficit. That is if you're not a midlife woman already under stress adding more stress by lacking fuel. But you won't gain lean muscle – which in the end actually improves your metabolism, energy, and round the clock fat burning.  If you're ready to take the first step or a step to regular strength training, confidence, and energy, click to the STRONGER program to learn more. Link in the show notes.  Questions ? Leave them below. Reference: Grzyb, Karolina1; Candow, Darren G.1; Schoenfeld, Brad J.2; Bernat, Patrick1; Butchart, Sara1; Neary, J. Patrick1 Effect of Equal Volume, High-Repetition Resistance Training to Volitional Fatigue, With Different Workout Frequencies, on Muscle Mass and Neuromuscular Performance in Postmenopausal Women, Journal of Strength and Conditioning Research: January 2022 - Volume 36 - Issue 1 - p 31-36. doi: 10.1519/JSC.0000000000003422 Other Episodes You Might Like:  3 Habits to Change to Stick to An Exercise Plan: https://www.flippingfifty.com/stick-to-an-exercise-plan/ Older, Faster, Stronger: https://www.flippingfifty.com/older-faster-stronger/ Your Fitness Your Relationship After 50 | Stronger in Both: https://www.flippingfifty.com/your-fitness-your-relationship-after-50-stronger-in-both/ 

AF conversion in the ED, HRT, a shining example of evidence-based medicine and less-is-more, multimorbidity, and what's coming at AHA are the topics John Mandrola, MD, covers in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. AF Conversion - IV Potassium and Magnesium an Acute Treatment for AF? https://www.medscape.com/viewarticle/983137 - Association of Intravenous Potassium and Magnesium Administration With Spontaneous Conversion of Atrial Fibrillation and Atrial Flutter in the Emergency Department https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2797474 II. HRT - USPSTF Doesn't Change Postmenopausal Hormone Recommendations https://www.medscape.com/viewarticle/983349 - Hormone Therapy To Prevent Disease and Prolong Life in Postmenopausal Women https://doi.org/10.7326/0003-4819-117-12-1016 - Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal WomenPrincipal Results From the Women's Health Initiative Randomized Controlled Trial https://jamanetwork.com/journals/jama/fullarticle/195120 - Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal PersonsUS Preventive Services Task Force Recommendation Statement https://jamanetwork.com/journals/jama/fullarticle/2797867 - Menopausal Hormone Therapy for Prevention of Chronic Conditions https://jamanetwork.com/journals/jama/fullarticle/2797897 III. BP Targets After Stroke Intervention - Intensive BP Lowering Harmful in Acute Ischemic Stroke: ENCHANTED2/MT https://www.medscape.com/viewarticle/983176 - Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial https://doi.org/10.1016/S0140-6736(22)01882-7 IV. Multimorbidity - ACC Issues Guidance on Integrating ASCVD and Multimorbidity Care https://www.medscape.com/viewarticle/983123 - 2022 ACC Expert Consensus Decision Pathway for Integrating Atherosclerotic Cardiovascular Disease and Multimorbidity Treatment: A Framework for Pragmatic, Patient-Centered Care: A Report of the American College of Cardiology Solution Set Oversight Committee https://www.jacc.org/doi/10.1016/j.jacc.2022.08.754 V. AHA Preview - AHA 2022 to Recapture In-Person Vibe but Preserve Global Reach https://www.medscape.com/viewarticle/983315 - Mandrola's Top 5 Picks From AHA 2022 Previewed https://www.medscape.com/viewarticle/983237 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

It's very common to assume that group-level findings from research will reliably predict how you (or your clients) will respond to a particular training strategy, but that's not always the case. In today's episode, Greg discusses the substantial amount of inter-individual variability observed in responses to training interventions, and how to navigate training decisions in light of these hard-to-predict differences among individuals. After that, Eric discusses protein quality: what it is, what affects it, and how much it does (or doesn't) matter from a practical perspective. His segment summarizes the research directly comparing a wide range of protein sources, and provides practical strategies for protein source selection in vegan, vegetarian, and omnivorous diets. SUPPORT THE PODCASTJoin the Research Spotlight newsletter: Get a two-minute breakdown of one recent study every Wednesday. Our newsletter is the easiest way to stay up to date with the latest exercise and nutrition science.MacroFactorIf you want to learn more about our MacroFactor diet app, check it out  here.To join in on the MacroFactor conversation, check out our Facebook group and subreddit.CoachingGet personalized training and nutrition plans from our expect coaches: Learn more hereMASS Research ReviewSubscribe to the MASS Research Review to get concise and applicable breakdowns of the latest strength, physique, and nutrition research – delivered monthly.Bulk SupplementsFinally, next time you stock up on supplements from BulkSupplements.com, be sure to use the promo code “SBSPOD” (all caps) to get 5% off your entire order. TIME STAMPSIntro/Announcements (0:00)Greg's segment: Individual responses versus group responses in resistance training (10:25)The importance of assessing individual-level responses (12:43)Study: Different Load Intensity Transition Schemes to Avoid Plateau and No-Response in Lean Body Mass Gain in Postmenopausal Women.  (17:40)Broader discussion of individual-level responses and variation from person-to-person (24:19)What has worked atypically well for Greg and Eric? (33:06)Eric's segment: protein quality (40:40)When you think about consuming raw eggs, what comes to mind? (40:46)Overview of protein quality (47:47)Protein – Which is Best?Digestibility of raw versus cooked eggs (49:24)Digestibility of Cooked and Raw Egg Protein in Humans as Assessed by Stable Isotope TechniquesStudy: Raw Eggs to Support Post-Exercise Recovery in Healthy Young Men: Did Rocky Get It Right or Wrong? (50:42)Raw Eggs to Support Post-Exercise Recovery in Healthy Young Men: Did Rocky Get It Right or Wrong?The “chain of assumptions” between protein quality, blood amino acid response, muscle protein synthesis response, and long-term hypertrophy (58:26)Amino acid profiles of various protein sources (1:01:30)The Skeletal Muscle Anabolic Response to Plant- versus Animal-Based Protein ConsumptionDirectly comparing high-quality versus low-quality protein sources (1:05:42)Protein Source and Quality for Skeletal Muscle Anabolism in Young and Older Adults: A Systematic Review and Meta-AnalysisAnimal Protein versus Plant Protein in Supporting Lean Mass and Muscle Strength: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsMaking Sense of Muscle Protein Synthesis: A Focus on Muscle Growth During Resistance TrainingA mycoprotein-based high-protein vegan diet supports equivalent daily myofibrillar protein synthesis rates compared with an isonitrogenous omnivorous diet in older adults: a randomised controlled trialHigh-Protein Plant-Based Diet Versus a Protein-Matched Omnivorous Diet to Support Resistance Training Adaptations: A Comparison Between Habitual Vegans and OmnivoresFlipping the “chain of assumptions” (1:14:03)How much protein comes from plant-based sources in an omnivorous diet? (1:16:58)The Skeletal Muscle Anabolic Response to Plant- versus Animal-Based Protein ConsumptionComplementary proteins and practical applications related to selection of protein sources (1:20:43)

Drs Lidia Schapira and Norah Lynn Henry discuss adjuvant endocrine therapy. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/969538). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals. Resources Adjuvant Endocrine Therapy for Women With Hormone Receptor–Positive Breast Cancer: ASCO Clinical Practice Guideline Focused Update https://ascopubs.org/doi/10.1200/JCO.18.01160 Evidence-Based Approaches for the Management of Side-Effects of Adjuvant Endocrine Therapy in Patients With Breast Cancer https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(20)30666-5/fulltext Acupuncture for Arthralgia-Induced by Aromatase Inhibitors in Patients With Breast Cancer: A Systematic Review and Meta-analysis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883140/ Long-Term Results From a Randomized Blinded Sham- and Waitlist-Controlled Trial of Acupuncture for Joint Symptoms Related to Aromatase Inhibitors in Early Stage Breast Cancer (S1200) https://ascopubs.org/doi/abs/10.1200/JCO.2021.39.15_suppl.12018 Adverse Events and Perception of Benefit From Duloxetine for Treating Aromatase Inhibitor-Associated Arthralgias https://academic.oup.com/jncics/article/5/2/pkab018/6130825 Predictors of Aromatase Inhibitor Discontinuation as a Result of Treatment-Emergent Symptoms in Early-Stage Breast Cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341106/ Active Symptom Monitoring and Endocrine Therapy Persistence in Young Women With Breast Cancer https://maps.cancer.gov/overview/DCCPSGrants/abstract.jsp?applId=10337861&term=CA266012 Patient-Reported Outcomes and Early Discontinuation in Aromatase Inhibitor-Treated Postmenopausal Women With Early Stage Breast Cancer https://academic.oup.com/oncolo/article/21/5/539/6401566?login=false Effect of a Switch of Aromatase Inhibitors on Musculoskeletal Symptoms in Postmenopausal Women With Hormone-Receptor-Positive Breast Cancer: The ATOLL (Articular Tolerance of Letrozole) Study https://pubmed.ncbi.nlm.nih.gov/20035381/ Benefits of Digital Symptom Monitoring With Patient-Reported Outcomes During Adjuvant Cancer Treatment https://ascopubs.org/doi/full/10.1200/JCO.20.03375 Cohort Study of Adherence to Adjuvant Endocrine Therapy, Breast Cancer Recurrence and Mortality https://www.nature.com/articles/bjc2013116 Atrophic Vaginitis in Breast Cancer Survivors: A Difficult Survivorship Issue https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493485/ Caution: Vaginal Estradiol Appears to Be Contraindicated in Postmenopausal Women on Adjuvant Aromatase Inhibitors https://www.annalsofoncology.org/article/S0923-7534(19)57558-5/fulltext Management of Genitourinary Syndrome of Menopause in Breast Cancer Survivors: An Update https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894268/

Dr. Angie Fearon (e-mail,  Google Scholar, Twitter) of the University of Canberra is interviewed by Dhinu Jayaseelan regarding a publication from BMC Musculoskeletal Disorders titled, “The natural history of greater trochanteric pain syndrome: an 11-year follow-up study.” This episode contains information that will be interesting for practitioners who want to improve their understanding of an understudied but ever-present diagnosis associated with clinical orthopaedics. Additionally, to find the LEAP study mentioned during the interview about exercise and education for GTPS use this link (Mellor et al 2018). Dr. Fearon also recommends checking out Ganderton et al 2017 (Title: Gluteal Loading Versus Sham Exercises to Improve Pain and Dysfunction in Postmenopausal Women with Greater Trochanteric Pain Syndrome: A Randomized Controlled Trial).Find out more about the American Academy of Orthopaedic Manual Physical Therapists at the following links:Academy website: www.aaompt.orgTwitter: @AAOMPTFacebook: https://www.facebook.com/aaompt/Instagram: https://www.instagram.com/officialaaompt/?hl=enPodcast e-mail: aaomptpodcast@gmail.comPodcast website: https://aaomptpodcast.simplecast.fm

Ray Gillenwater and Inna Koppel talk about all the benefits postmenopausal women have from strength training, training pre/post pregnancy, and female culture evolution. 03:24 Benefits of strength training for postmenopausal women 07:47 Senior strength Starting Strength Boise 09:24 Kathleen Starting Strength Denver 11:51 Allison Starting Strength Boise 13:46 Female culture evolution and where things stand now 18:07 Bulking 21:29 Gaining muscle and losing fat 30:20 Rehab and prehab for women with the barbell 38:19 Benefits from training pre/post-pregnancy 43:23 The fitness industry/why barbells 54:00 How to contact Inna

Allmennlege Sjur Even Aunmo fikk sparken som fastlegevikar fordi han fortalte pasienter at COVID-19-vaksinen kan gi bivirkninger. Dette er noe han plikter å gjøre ifølge Pasient- og brukerrettighetsloven § 4. Aunmo har satt seg grundig inn i forskningen på disse vaksinene, og påpeker at de for det første er eksperimentelle på dette stadiet. Videre er det Pfizer selv som har finansiert sin studie, en ansatt fikk sparken fordi hun varslet om at blindingen (anonymiseringen) var brutt, personer har blitt tatt ut av studien uten at det er oppgitt noen god grunn og rådataene for studien er ikke offentliggjort. Selv har han sett flere bivirkninger, som kraftige menstruasjonsblødninger, hjerteproblemer og alvorlige nevrologiske bivirkninger. Han frykter at underrapportering kan medføre at bivirkningstallene fra Statens legemiddelverk er for lave. KILDER:› COVID-19 • https://clinicaltrials.gov/ct2/show/NCT04368728 • https://clinicaltrials.gov/ct2/show/NCT04470427 • Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine • Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase • https://covid-nma.com/vaccines/variants/ • https://covid-nma.com/vaccines/index.php?search_by=1&search_input=1273&submit=Validate#moteur_recherche • How significant is the Ventavia scandal? • Covid-19: Researcher blows the whistle on data integrity issues in Pfizer's vaccine trial • CDC-vurdering av Modernas studie • https://www.bmj.com/company/newsroom/editors-call-for-covid-19-vaccine-and-treatment-data-to-be-available-for-public-scrutiny/ • https://www.nrk.no/norge/norges-forste-koronavaksine-settes-1.15304159, lest 20.3.22 • https://tidsskriftet.no/2021/05/originalartikkel/dodsfall-i-sykehjem-etter-covid-19-vaksine ◦ https://www.fhi.no/hn/helseregistre-og-registre/dodsarsaksregisteret/tall-for-covid-19-assosierte-dodsfall-i-dodsarsaksregisteret-i-2020/ ◦ https://legemiddelverket.no/Documents/Bivirkninger%20og%20sikkerhet/Rapporter%20og%20oversikter/Koronavaksiner/20211028%20Rapport%20over%20meldte%20bivirkninger%20av%20koronavaksine.pdf ◦ Surveillance for safety after immunization; vaccine adverse event reporting system (VAERS) - United States 1991-2001 ◦ Mandatory Reporting of Infectious Diseases by Clinicians ◦ Myopericarditis after vaccination, Vaccine Adverse Event Reporting System (VAERS), 1990–2018 ◦ https://www.nrk.no/livsstil/_-en-medisinsk-katastrofe-1.10880384 ◦ https://legemiddelverket.no/nyheter/bivirkninger-av-vaksiner-hva-lerte-vi-av-pandemien-i-2009#ble-det-meldt-noen-d%C3%B8dsfall? ◦ The illusion of evidence based medicine ‧ Amerikanske Centers for Disease Control om underrapportering ‧ Studie fra det medisinske tidsskriftet JAMA om underrapportering ‧ Studie fra det medisinske tidsskriftet Vaccine om underrapportering ‧ Fra det amerikanske registrerings-systemet VAERS om deres system ‧ Randomised Clinical Trials of COVID-19 Vaccines: Do Adenovirus-Vector Vaccines Have Beneficial Non-Specific Effects? ‧ Lancet 2022. Samlestudie RCT. Obs: Preprrint, ikke fagfallevurdert enda. Signifikant og stor forskjell mellom Pfizer/Moderna og svekket-virus-vaksiner.› FETT • Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis • Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73) • Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease • The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials • Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review • http://dx.doi.org/10.1136/openhrt-2014-000196 • Fat or fiction: the diet-heart hypothesis | BMJ Evidence-Based Medicine • https://www.mn.uio.no/ibv/tjenester/kunnskap/plantefys/leksikon/h/herdet-fett.html • 4-Hydroxynonenal-Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease • https://doi.org/10.1016/j.freeradbiomed.2006.07.021 ◦ Dietary stearic acid regulates mitochondria in vivo in humans - Nature Communications ◦ 33.9 10.17140/AFTNSOJ-1-123 Oxidation of Polyunsaturated Fatty Acids and its Impact on Food Quality and Human Health ◦ Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells ◦ Effect of the Type of Frying Culinary Fat on Volatile Compounds Isolated in Fried Pork Loin Chops by Using SPME-GC-MS› STATINER • BMJ RCT sysrew/meta Statins for the primary prevention of cardiovascular disease: an overview of systematic reviews • The effect of statins on average survival in randomised trials, an analysis of end point postponement • JAMA RCT-meta 2010 - Statins and All-Cause Mortality in High-Risk Primary Prevention: A Meta-analysis of 11 Randomized Controlled Trials Involving 65 229 Participants • https://www.felleskatalogen.no/medisin/lipitor-upjohn-eesv-pfizer-560999 • https://www.felleskatalogen.no/medisin/zocor-organon-565655 • https://www.legemiddelhandboka.no/L8.15.1/Statiner • Statins - a call for transparent data - The BMJ • Statin Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women's Health Initiative› KJØTT • Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes A Systematic Review of Randomized Trials • Total red meat intake of ≥0.5 servings/d does not negatively influence cardiovascular disease risk factors: a systemically searched meta-analysis of randomized controlled trials› KOLESTEROL • Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review • Inborn coagulation factors are more important cardiovascular risk factors than high LDL-cholesterol in familial hypercholesterolemia • PMID: 18277343 ApoB/ApoA1 ratio and subclinical atherosclerosis ◦ Cigarette smoking renders LDL susceptible to peroxidative modification and enhanced metabolism by macrophages ◦ Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia: Role of Oxidized LDL ◦ Passive Smoking Induces Atherogenic Changes in Low-Density Lipoprotein ◦ Smoking and smoking cessation—The relationship between cardiovascular disease and lipoprotein metabolism: A review ◦ Smoking and Cardiovascular Disease ◦ LDL biochemical modifications: a link between atherosclerosis and aging ◦ Association Between Circulating Oxidized LDL and Atherosclerotic Cardiovascular Disease: A Meta-analysis of Observational Studies› KARBOHYDRAT • https://www.helsedirektoratet.no/rapporter/anbefalinger-om-kosthold-ernaering-og-fysisk-aktivitet/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf/_/attachment/inline/2f5d80b2-e0f7-4071-a2e5-3b080f99d37d:2aed64b5b986acd14764b3aa7fba3f3c48547d2d/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf› DIABETES • JAMA WMI 2006Low-Fat Dietary Pattern and Risk of Cardiovascular DiseaseThe Women's Health Initiative Randomized Controlled Dietary Modification Trial – se side 661, økt hjerte/kar-risk sfa. Lavfett-diett • AmJourClinNutr WMI 2011 Effects of a low-fat dietary intervention on glucose, insulin, and insulin resistance in the Women's Health Initiative (WHI) Dietary Modification trial • AOCS Lipids (lavranket journal) Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet • Small Dense Low-Density Lipoprotein-Cholesterol Concentrations Predict Risk for Coronary Heart Disease- ArtThromVas prospektiv kohort • Glycation as an atherogenic modification of LDL : Current Opinion in Lipidology • Glycosylated low density lipoprotein is more sensitive to oxidation: implications for the diabetic patient? • Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo› DIABETES-DEMENS • AgeingResearchRewiew 2019 sysrew/meta 144 prospektive studier – 58 % økt risiko demens • Int. Med. Journ. 2012 meta-analyse av prospektive kohorter dia-demens-risk 51 % økning demens • Lancet Neurology 2006, sysrew lavere evidensgrad. Risk of dementia in diabetes mellitus: a systematic review • Diabetes mellitus and the risk of dementia - The Rotterdam Study – prospektiv kohort • JDST 2008 Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed • MDPI 2015 Evaluating the Association between Diabetes, Cognitive Decline and Dementia • Ketone Bodies Promote Amyloid-β1–40 Clearance in a Human in Vitro Blood–Brain Barrier Model - 2020 • Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implication - 2018 • APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline - 2020› HJERTE- OG KAR-SYKDOM • 10.1001/jamacardio.2020.7073 Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident Coronary Heart Disease in Women› PLANTE-ANTINÆRINGSSTOFF OG VERN • Food Chemistry 2008 Bioaccessibility of Ca, Mg, Mn and Cu from whole grain tea-biscuits: Impact of proteins, phytic acid and polyphenols • Phytate in foods and significance for humans: food sources, intake, processing, bioavailability, protective role and analysis. Mol Nutr Food Res. 2009 Sep;53 Suppl 2:S330-75. • Oxalate content of foods and its effect on humans • Lectins as plant defense proteins • Effects of wheat germ agglutinin on human gastrointestinal epithelium: Insights from an experimental model of immune/epithelial cell interaction • Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat • Identification of intact peanut lectin in peripheral venous blood • Do dietary lectins cause disease? BMJ • Lectin binding of endometrium in women with unexplained infertility • Changes in organs and tissues induced by feeding of purified kidney bean (Phaseolus vulgaris) lectins • Insecticidal Activity of Plant Lectins and Potential Application in Crop Protection • Bound Lectins that Mimic Insulin Produce Persistent Insulin-Like Activities • Contribution of leptin receptor N-linked glycans to leptin binding • Potato lectin activates basophils and mast cells of atopic subjects by its interaction with core chitobiose of cell-bound non-specific immunoglobulin E • 3.0.CO;2-T Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils • Secondary Oxalate Nephropathy: A Systematic Review • The effect of tea on iron absorption • PMID: 1862 Disler PB, Lynch SR, Torrance JD, et al. The mechanism of the inhibition of iron absorption by tea. The South African Journal of Medical Sciences. 1975 ;40(4):109-116. • Effects of saponins and glycoalkaloids on the permeability and viability of mammalian intestinal cells and on the integrity of tissue preparationsin vitro • The biological action of saponins in animal systems: a review • Small Amounts of Gluten in Subjects With Suspected Nonceliac Gluten Sensitivity: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial ◦ Obs: Kapsler brukt i studien ble supplert av legemiddelfirmaet Giuliani, som lager glutenfritt brød.› LEKK TARM • Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines • Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3 • AmJourClinNu 2009 Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford) • FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction • 73.3 10.12688/f1000research.20510.1 All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases› LAVKARB • Effects of Low-Carbohydrate vs Low-Fat Diets on Weight Loss and Cardiovascular Risk Factors • BritJourNutr 2013 RCT-meta Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials • AnnIntMed 2004 A Low-Carbohydrate, Ketogenic Diet versus a Low-Fat Diet To Treat Obesity and Hyperlipidemia: A Randomized, Controlled Trial • JAMAIntMed A Randomized Trial of a Low-Carbohydrate Diet vs Orlistat Plus a Low-Fat Diet for Weight Loss • NEJM RCT 2006 A Low-Carbohydrate as Compared with a Low-Fat Diet in Severe Obesity • Short-term effects of severe dietary carbohydrate-restriction advice in Type 2 diabetes—a randomized controlled trial • Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial • Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factor in overweight adolescents • Comparison of the Atkins, Zone, Ornish, and LEARN Diets for Change in Weight and Related Risk Factors Among Overweight Premenopausal WomenThe A TO Z Weight Loss Study: A Randomized Trial • Efficacy and Safety of a High Protein, Low Carbohydrate Diet for Weight Loss in Severely Obese Adolescents • Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial› FRUKTOSE • JourHepatology 2021 Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial • Effects of fructose restriction on liver steatosis (FRUITLESS); a double-blind randomized controlled trial› KETOGENISITET/KREFT • https://oslo-universitetssykehus.no/behandlinger/pet-undersokelse • https://stanfordhealthcare.org/medical-tests/p/pet-scan/what-to-expect.html • https://www.sciencedirect.com/topics/medicine-and-dentistry/warburg-effect • The Warburg Effect: How Does it Benefit Cancer Cells? • NutrCanc 2019 Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study • Dietary Glycemic Load and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings From CALGB 89803 • Ketogenic diet in cancer therapy› IATROGEN SKADE • https://tidsskriftet.no/2000/10/kronikk/uheldige-hendelser-i-helsetjenesten-forebygging-og-handteringOpptaksdato: 2022-05-02Publiseringsdato: 2022-05-22Last ned episoden

Allmennlege Sjur Even Aunmo fikk sparken som fastlegevikar fordi han fortalte pasienter at COVID-19-vaksinen kan gi bivirkninger. Dette er noe han plikter å gjøre ifølge Pasient- og brukerrettighetsloven § 4. Aunmo har satt seg grundig inn i forskningen på disse vaksinene, og påpeker at de for det første er eksperimentelle på dette stadiet. Videre er det Pfizer selv som har finansiert sin studie, en ansatt fikk sparken fordi hun varslet om at blindingen (anonymiseringen) var brutt, personer har blitt tatt ut av studien uten at det er oppgitt noen god grunn og rådataene for studien er ikke offentliggjort. Selv har han sett flere bivirkninger, som kraftige menstruasjonsblødninger, hjerteproblemer og alvorlige nevrologiske bivirkninger. Han frykter at underrapportering kan medføre at bivirkningstallene fra Statens legemiddelverk er for lave. KILDER:› COVID-19 • https://clinicaltrials.gov/ct2/show/NCT04368728 • https://clinicaltrials.gov/ct2/show/NCT04470427 • Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine • Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase • https://covid-nma.com/vaccines/variants/ • https://covid-nma.com/vaccines/index.php?search_by=1&search_input=1273&submit=Validate#moteur_recherche • How significant is the Ventavia scandal? • Covid-19: Researcher blows the whistle on data integrity issues in Pfizer's vaccine trial • CDC-vurdering av Modernas studie • https://www.bmj.com/company/newsroom/editors-call-for-covid-19-vaccine-and-treatment-data-to-be-available-for-public-scrutiny/ • https://www.nrk.no/norge/norges-forste-koronavaksine-settes-1.15304159, lest 20.3.22 • https://tidsskriftet.no/2021/05/originalartikkel/dodsfall-i-sykehjem-etter-covid-19-vaksine ◦ https://www.fhi.no/hn/helseregistre-og-registre/dodsarsaksregisteret/tall-for-covid-19-assosierte-dodsfall-i-dodsarsaksregisteret-i-2020/ ◦ https://legemiddelverket.no/Documents/Bivirkninger%20og%20sikkerhet/Rapporter%20og%20oversikter/Koronavaksiner/20211028%20Rapport%20over%20meldte%20bivirkninger%20av%20koronavaksine.pdf ◦ Surveillance for safety after immunization; vaccine adverse event reporting system (VAERS) - United States 1991-2001 ◦ Mandatory Reporting of Infectious Diseases by Clinicians ◦ Myopericarditis after vaccination, Vaccine Adverse Event Reporting System (VAERS), 1990–2018 ◦ https://www.nrk.no/livsstil/_-en-medisinsk-katastrofe-1.10880384 ◦ https://legemiddelverket.no/nyheter/bivirkninger-av-vaksiner-hva-lerte-vi-av-pandemien-i-2009#ble-det-meldt-noen-d%C3%B8dsfall? ◦ The illusion of evidence based medicine ‧ Amerikanske Centers for Disease Control om underrapportering ‧ Studie fra det medisinske tidsskriftet JAMA om underrapportering ‧ Studie fra det medisinske tidsskriftet Vaccine om underrapportering ‧ Fra det amerikanske registrerings-systemet VAERS om deres system ‧ Randomised Clinical Trials of COVID-19 Vaccines: Do Adenovirus-Vector Vaccines Have Beneficial Non-Specific Effects? ‧ Lancet 2022. Samlestudie RCT. Obs: Preprrint, ikke fagfallevurdert enda. Signifikant og stor forskjell mellom Pfizer/Moderna og svekket-virus-vaksiner.› FETT • Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis • Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73) • Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease • The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials • Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review • http://dx.doi.org/10.1136/openhrt-2014-000196 • Fat or fiction: the diet-heart hypothesis | BMJ Evidence-Based Medicine • https://www.mn.uio.no/ibv/tjenester/kunnskap/plantefys/leksikon/h/herdet-fett.html • 4-Hydroxynonenal-Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease • https://doi.org/10.1016/j.freeradbiomed.2006.07.021 ◦ Dietary stearic acid regulates mitochondria in vivo in humans - Nature Communications ◦ 33.9 10.17140/AFTNSOJ-1-123 Oxidation of Polyunsaturated Fatty Acids and its Impact on Food Quality and Human Health ◦ Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells ◦ Effect of the Type of Frying Culinary Fat on Volatile Compounds Isolated in Fried Pork Loin Chops by Using SPME-GC-MS› STATINER • BMJ RCT sysrew/meta Statins for the primary prevention of cardiovascular disease: an overview of systematic reviews • The effect of statins on average survival in randomised trials, an analysis of end point postponement • JAMA RCT-meta 2010 - Statins and All-Cause Mortality in High-Risk Primary Prevention: A Meta-analysis of 11 Randomized Controlled Trials Involving 65 229 Participants • https://www.felleskatalogen.no/medisin/lipitor-upjohn-eesv-pfizer-560999 • https://www.felleskatalogen.no/medisin/zocor-organon-565655 • https://www.legemiddelhandboka.no/L8.15.1/Statiner • Statins - a call for transparent data - The BMJ • Statin Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women's Health Initiative› KJØTT • Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes A Systematic Review of Randomized Trials • Total red meat intake of ≥0.5 servings/d does not negatively influence cardiovascular disease risk factors: a systemically searched meta-analysis of randomized controlled trials› KOLESTEROL • Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review • Inborn coagulation factors are more important cardiovascular risk factors than high LDL-cholesterol in familial hypercholesterolemia • PMID: 18277343 ApoB/ApoA1 ratio and subclinical atherosclerosis ◦ Cigarette smoking renders LDL susceptible to peroxidative modification and enhanced metabolism by macrophages ◦ Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia: Role of Oxidized LDL ◦ Passive Smoking Induces Atherogenic Changes in Low-Density Lipoprotein ◦ Smoking and smoking cessation—The relationship between cardiovascular disease and lipoprotein metabolism: A review ◦ Smoking and Cardiovascular Disease ◦ LDL biochemical modifications: a link between atherosclerosis and aging ◦ Association Between Circulating Oxidized LDL and Atherosclerotic Cardiovascular Disease: A Meta-analysis of Observational Studies› KARBOHYDRAT • https://www.helsedirektoratet.no/rapporter/anbefalinger-om-kosthold-ernaering-og-fysisk-aktivitet/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf/_/attachment/inline/2f5d80b2-e0f7-4071-a2e5-3b080f99d37d:2aed64b5b986acd14764b3aa7fba3f3c48547d2d/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf› DIABETES • JAMA WMI 2006Low-Fat Dietary Pattern and Risk of Cardiovascular DiseaseThe Women's Health Initiative Randomized Controlled Dietary Modification Trial – se side 661, økt hjerte/kar-risk sfa. Lavfett-diett • AmJourClinNutr WMI 2011 Effects of a low-fat dietary intervention on glucose, insulin, and insulin resistance in the Women's Health Initiative (WHI) Dietary Modification trial • AOCS Lipids (lavranket journal) Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet • Small Dense Low-Density Lipoprotein-Cholesterol Concentrations Predict Risk for Coronary Heart Disease- ArtThromVas prospektiv kohort • Glycation as an atherogenic modification of LDL : Current Opinion in Lipidology • Glycosylated low density lipoprotein is more sensitive to oxidation: implications for the diabetic patient? • Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo› DIABETES-DEMENS • AgeingResearchRewiew 2019 sysrew/meta 144 prospektive studier – 58 % økt risiko demens • Int. Med. Journ. 2012 meta-analyse av prospektive kohorter dia-demens-risk 51 % økning demens • Lancet Neurology 2006, sysrew lavere evidensgrad. Risk of dementia in diabetes mellitus: a systematic review • Diabetes mellitus and the risk of dementia - The Rotterdam Study – prospektiv kohort • JDST 2008 Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed • MDPI 2015 Evaluating the Association between Diabetes, Cognitive Decline and Dementia • Ketone Bodies Promote Amyloid-β1–40 Clearance in a Human in Vitro Blood–Brain Barrier Model - 2020 • Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implication - 2018 • APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline - 2020› HJERTE- OG KAR-SYKDOM • 10.1001/jamacardio.2020.7073 Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident Coronary Heart Disease in Women› PLANTE-ANTINÆRINGSSTOFF OG VERN • Food Chemistry 2008 Bioaccessibility of Ca, Mg, Mn and Cu from whole grain tea-biscuits: Impact of proteins, phytic acid and polyphenols • Phytate in foods and significance for humans: food sources, intake, processing, bioavailability, protective role and analysis. Mol Nutr Food Res. 2009 Sep;53 Suppl 2:S330-75. • Oxalate content of foods and its effect on humans • Lectins as plant defense proteins • Effects of wheat germ agglutinin on human gastrointestinal epithelium: Insights from an experimental model of immune/epithelial cell interaction • Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat • Identification of intact peanut lectin in peripheral venous blood • Do dietary lectins cause disease? BMJ • Lectin binding of endometrium in women with unexplained infertility • Changes in organs and tissues induced by feeding of purified kidney bean (Phaseolus vulgaris) lectins • Insecticidal Activity of Plant Lectins and Potential Application in Crop Protection • Bound Lectins that Mimic Insulin Produce Persistent Insulin-Like Activities • Contribution of leptin receptor N-linked glycans to leptin binding • Potato lectin activates basophils and mast cells of atopic subjects by its interaction with core chitobiose of cell-bound non-specific immunoglobulin E • 3.0.CO;2-T Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils • Secondary Oxalate Nephropathy: A Systematic Review • The effect of tea on iron absorption • PMID: 1862 Disler PB, Lynch SR, Torrance JD, et al. The mechanism of the inhibition of iron absorption by tea. The South African Journal of Medical Sciences. 1975 ;40(4):109-116. • Effects of saponins and glycoalkaloids on the permeability and viability of mammalian intestinal cells and on the integrity of tissue preparationsin vitro • The biological action of saponins in animal systems: a review • Small Amounts of Gluten in Subjects With Suspected Nonceliac Gluten Sensitivity: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial ◦ Obs: Kapsler brukt i studien ble supplert av legemiddelfirmaet Giuliani, som lager glutenfritt brød.› LEKK TARM • Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines • Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3 • AmJourClinNu 2009 Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford) • FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction • 73.3 10.12688/f1000research.20510.1 All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases› LAVKARB • Effects of Low-Carbohydrate vs Low-Fat Diets on Weight Loss and Cardiovascular Risk Factors • BritJourNutr 2013 RCT-meta Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials • AnnIntMed 2004 A Low-Carbohydrate, Ketogenic Diet versus a Low-Fat Diet To Treat Obesity and Hyperlipidemia: A Randomized, Controlled Trial • JAMAIntMed A Randomized Trial of a Low-Carbohydrate Diet vs Orlistat Plus a Low-Fat Diet for Weight Loss • NEJM RCT 2006 A Low-Carbohydrate as Compared with a Low-Fat Diet in Severe Obesity • Short-term effects of severe dietary carbohydrate-restriction advice in Type 2 diabetes—a randomized controlled trial • Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial • Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factor in overweight adolescents • Comparison of the Atkins, Zone, Ornish, and LEARN Diets for Change in Weight and Related Risk Factors Among Overweight Premenopausal WomenThe A TO Z Weight Loss Study: A Randomized Trial • Efficacy and Safety of a High Protein, Low Carbohydrate Diet for Weight Loss in Severely Obese Adolescents • Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial› FRUKTOSE • JourHepatology 2021 Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial • Effects of fructose restriction on liver steatosis (FRUITLESS); a double-blind randomized controlled trial› KETOGENISITET/KREFT • https://oslo-universitetssykehus.no/behandlinger/pet-undersokelse • https://stanfordhealthcare.org/medical-tests/p/pet-scan/what-to-expect.html • https://www.sciencedirect.com/topics/medicine-and-dentistry/warburg-effect • The Warburg Effect: How Does it Benefit Cancer Cells? • NutrCanc 2019 Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study • Dietary Glycemic Load and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings From CALGB 89803 • Ketogenic diet in cancer therapy› IATROGEN SKADE • https://tidsskriftet.no/2000/10/kronikk/uheldige-hendelser-i-helsetjenesten-forebygging-og-handteringDownload this episodeRecorded: 2022-05-02Published: 2022-05-22

Among several recent essential oil-related research papers published, I came across one titled The Effect of Citrus Aurantium Aroma on the Sleep Quality in Postmenopausal Women: A Randomized Controlled Trial. Poor sleep quality is one of the most common problems postmenopausal women deal with. This study looked at how inhalation of neroli essential oil might impact sleep quality. What is neroli? Neroli essential oil comes from the flowers of the Citrus aurantium, or bitter orange tree. This sometimes creates confusion in natural products, as the bitter orange itself is also used as a nutritional supplement.  Bitter orange contains synephrine, a close cousin of ephedrine, which has been shown to support fat loss without the adverse cardiovascular effects of ephedrine. A Citrus aurantium subspecies called Citrus aurantium bergamia is also useful in natural health. This is where we get bergamot from. With all that said, the focus of this blog post is on neroli, the essential oil from the flowers of the bitter orange tree. Previous research on neroli According to a 2018 review, neroli has the following biological properties in humans or animals: Biological Properties of Citrus Aurantium EssenceAnti-amnesicAntibacterialAntifungalAntioxidantAnti-inflammatoryAntiseizure and anticonvulsantAnxiolytic and antidepressantCentral and peripheral antinociceptive effectsEndothelium- and smooth muscle-dependent vasodilatorHypotensiveMenopausal symptoms reliefPremenstrual syndrome (PMS) reliefSedative, soothing, motor relaxantSexual desire enhancerAdapted from Biological Activities and Safety of Citrus spp. Essential Oils, Table 3 The effects may vary based on whether neroli essential oil is used internally, topically, or aromatically.  Read also: Tangerine Essential Oil, Sedation, Sleep, and Focused Thinking. Postmenopausal Changes Post-menopause, women experience a variety of health challenges due to their significantly-reduced estrogen levels. Difficulty with sleep is the most common. Sleep problems arise due to a reduction in melatonin and serotonin that follows a large drop in estrogen. Hot flashes may also cause women to wake often during the night. Though the hormonal shift itself may lead to sleep loss and health problems, prolonged sleep debt may amplify these health problems as well. Conventional medicine offers some solutions, but with serious risks. Hormonal therapy, sedative and hypnotic drugs are the treatment methods for sleep disorders but they can cause harmful effects such as breast cancer, thrombosis, drowsiness, and impaired mental ability.Abbaspoor Z, et al. Neroli Essential Oil and Sleep in Postmenopausal Women As mentioned above, previous studies have shown that neroli essential oil helps with many menopausal symptoms.  As for sleep, aromatherapy with neroli essential oil improved sleep in studies with people who had type II diabetes, ischemic heart disease, or heart failure, and in female nursing students. In this recent, randomized, controlled trial, researchers divided 80 postmenopausal women, ages 45-60, with sleep problems into two groups: A control group and an intervention group. The control group received a bottle of almond oil. The intervention group received a bottle containing a 10% concentration of neroli essential oil. Researchers instructed both groups to put two drops of the oil they received on their left or right forearm skin, and hold their forearm 30 cm (about 1 ft.) from their nose for five minutes, twice per day, for four consecutive days per week for four weeks. They completed the Pittsburgh Sleep Quality Index (PSQI) before the trial and at the end of the four weeks. Consistent with other studies, the women who used the essential oil experienced a significant improvement in sleep quality. It's also worth mentioning that no adverse events were reported.  Read also: Effects of Rose Essential Oil on Sleep and Feelings...

Another fascinating conversation with Dr. Kenna Stephenson, M.D., a pioneering Family Medicine physician who has dedicated her life's work to helping women in menopause find safer solutions for symptom relief and quality of life as we age backed by science and rigorous research. Early in her career Dr. Kenna recognized that within the medical profession, there was a notable lack of scientific approach to menopause medicine, and a tendency among traditional doctors to delegitimate hormonal issues in aging women. Over and over again, she heard from women patients how hard it was to find a doctor who took their symptoms seriously, how they had been dismissed with insensitive comments such as “it's all in your head,” OR “you're getting older, get used to it,” OR “you're just depressed,” and waved away with a prescription for Prozac. Dr. Kenna was all too aware that few if any studies in the scientific literature researched the health risks among women in menopause (or perimenopause the years leading up to it), or looked into the benefits of safer alternatives to the ubiquitous use of synthetic hormones shown to have adverse effects (increased heart disease, stroke, blood clots, breast cancers) over time. As a physician dedicated to the art and science of women's medicine, Kenna knew that there were better alternatives than HRT, as evidenced by the symptom relief and positive health benefits of the patients she was treating with plant-based bioidentical hormones. At the same time, it was deeply disturbing to her that the great majority of women who could and should benefit from these more natural hormone approaches were “missing out”. As her concerns amplified, Kenna set out to provide hard core evidence that bioidentical hormones were a viable alternative to HRT, one used in Europe and available to providers and patients in the US. Thus was conceived the landmark CHOIICE study that looked into the effects of compounded bioidentical hormone therapies in peri and postmenopausal women. In this fascinating discussion Dr. Stephenson talks openly with Kyle and Candace about her uphill battle to breathe life into the CHOIICE study, to recruit suitable subjects and find the funding and support so crucial to conducting an independent study without the backing of Big-Pharma. She describes the many obstacles that stood in her way from the critics and naysayers to Hurricane Katrina, and how through sheer perseverance of her research team and dedicated subjects the roadblocks were painstakingly overcome one by one. The project prevailed and the published results of the peer-reviewed CHOIICE study * clearly proved that bioidentical hormones work! And that the BHRT (Bioidentical Hormone Restoration Therapy) model of care when administered in physiologic doses tailored to individual need, significantly relieved menopausal symptoms AND improved health outcomes in all the major areas studied -cardiovascular, inflammatory, immune, mood and quality of life bio-markers – with NO adverse effects. This is exciting, groundbreaking research to write home about, or more specifically share with your doctor, especially if he/she is a doubting Thomas or Thomasina! You can learn more and follow Dr. Kenna on UTUBE Here's a great interview with Dr. Kenna: https://www.healthwatchersnews.com/2009/11/bioidentical-hormone-research-shows-heart-benefits/ * The effects of compounded bioidentical transdermal hormone therapy on hemostatic, inflammatory, immune factors; cardiovascular biomarkers; quality-of-life measures; and health outcomes in perimenopausal and postmenopausal women https://pubmed.ncbi.nlm.nih.gov/23627249/

While exercise is crucial to our health in so many ways, a new study suggests that standing and walking can be almost as helpful. In the study, published in the journal Diabetologia, Dutch researchers had postmenopausal women do four weeks of sitting for 14 hours a day, four weeks with one hour of vigorous exercise […] The post 71. Moderate walking and standing appears almost as good as exercise for postmenopausal women appeared first on Dr. David Geier - Feel and Perform Better Than Ever.

Are you quaking in your boots thinking that time is passing you by and you're getting older by the minute? Take a deep breath and take a listen because I know that this episode is going to light you up!My special guest this week is Rachel Lankester, author of Magnificent Midlife, Transform Your Middle Years, Menopause and Beyond. Rachel also hosts the Magnificent Midlife podcast and is a midlife mentor and founder of Magnificent Midlife - An Online Club Celebrating and Empowering Women 40 and Over. Rachel's own early onset menopause put her on a mission to change how society perceives women, and how women perceive themselves through midlife and beyond. In this episode, Rachel shares the joys available to us during the period of our lives we call midlife and educates us on what all women can do to make sure they are thriving physically, mentally and emotionally in midlife.If you want to develop a more positive self view and view of aging to be prepared... not scared of what is to come for you through midlife, this episode is for you! It certainly changed my mind about what is ahead for me in my life. Timestamps: [3:54] Rachel talks about her diagnosis of early menopause at age 41 [5:51] “The end of my fertility has actually become the most fertile time of my life.”[8:47] “We have been taught to believe that menopause is the end of meaningful life.”[13:27] Rachel talks about ageism and shares a quote about ageism beginning between our ears  [16:27] Menopause, the average age of its onset, and fluctuating hormones[24:25] Dr. Li recaps the top tips Rachel shared throughout the episode  For more information on the Make Time for Success podcast, visit:https://www.maketimeforsuccesspodcast.comConnect with Us!Dr. Christine Li -Website: https://www.procrastinationcoach.comFacebook: https://www.facebook.com/groups/procrastinationcoachInstagram: https://www.instagram.com/procrastinationcoach/To learn how to work with Dr. Li in a fun, meaningful, collaborative setting, read about The Success Lab here: https://www.procrastinationcoach.com/labRachel Lankester - Website: https://magnificentmidlife.com/Facebook: https://www.facebook.com/magnificentmidlife/Instagram: https://www.instagram.com/magnificentmidlife/LinkedIn: https://www.linkedin.com/in/rachellankester/Rachel's free resources page: https://magnificentmidlife.com/resources/Rachel's book: https://magnificentmidlife.com/book/

If you're postmenopausal, you may want to avoid calcium supplements and do this instead! FREE COURSE ➜ ➜ https://courses.drberg.com/product/how-to-bulletproof-your-immune-system/ FREE MINI-COURSE ➜ ➜ Take Dr. Berg's Free Keto Mini-Course! Talk to a Dr. Berg Keto Consultant today and get the help you need on your journey (free consultation). Call 1-540-299-1557 with your questions about Keto, Intermittent Fasting, or the use of Dr. Berg products. Consultants are available Monday through Friday from 8 AM to 10 PM EST. Saturday & Sunday from 9 AM to 6 PM EST. USA Only. Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. Dr. Berg's Website: http://bit.ly/37AV0fk Dr. Berg's Recipe Ideas: http://bit.ly/37FF6QR Dr. Berg's Reviews: http://bit.ly/3hkIvbb Dr. Berg's Shop: http://bit.ly/3mJcLxg Dr. Berg's Bio: http://bit.ly/3as2cfE Dr. Berg's Health Coach Training: http://bit.ly/3as2p2q Facebook: https://www.facebook.com/drericberg Messenger: https://www.messenger.com/t/drericberg Instagram: https://www.instagram.com/drericberg/ YouTube: http://bit.ly/37DXt8C

Host: Alan S. Brown, MD, FACC, FAHA, FNLA Guest: Yvonne Michael, ScD, SM Dr. Yvonne Michael, an Associate Professor at the Dornsife School of Public Health at Drexel University, discusses risk factors that we should take into consideration when examining postmenopausal patients with coronary heart disease.

Having been exposed to the medical, metabolic, and physiological gender-based factors associated with weight gain, weight loss, body composition changes, and the psychological aspects in a diverse cross-section of male and female participants in my prior hospital-affiliated wellness and weight management programs over the last thirty years, I can attest to the fact that what you eat, when you eat—along with age and health profile, account for many of the complex issues associate with weight control.Biologically speaking (circadian rhythm), late night eating certainly has its drawbacks on metabolic rate, cardiometabolic health, hormone secretion (melatonin production), and fat oxidation versus storage.Prior research and common sense have demonstrated that eating chocolate late at night has been associated with long-term weight gain, especially in postmenopausal women (average age of 51), who are vulnerable to weight gain. It appears now that chocolate and the timing of its consumption may have earned a bad rap.Research—"Timing of Chocolate Intake Affects Hunger, Substrate Oxidation, and Microbiota: a Randomized Controlled Trail”—reported in the July online issue of the FASEB journal (the journal of the Federation of American Societies for Experimental Biology), suggests that, “chocolate, in the morning or in the evening/night, in a narrow window of time (1 hour), results in differential effects on hunger and appetite, substrate oxidation, fasting glucose, microbiota composition and function, and sleep and temperature rhythms.” “The intake of a rather high amount of chocolate (100 grams),” comment the researchers from Brigham and Woman's Hospital in Boston, “concentrated in a narrow (1 hour) timing window in the morning could help to burn body fat and to decrease glucose levels in postmenopausal women.”This determination involved 19 postmenopausal females, who completed a nine week, randomized, controlled, cross-over trial of “ad libitum food” intake —with either 100 grams of chocolate (~33% of their daily energy intake) in the morning, defined as within one hour after waking time, or at evening/night —within one hour before bedtime, compared to no chocolate intake. The duration of each intervention was two weeks, which included a transition period.The study participants underwent the following tests and measurements:Body weight (baseline and three additional timed dates), height, body fat, dietary food intake record, visual analog scale before and after each meal (hunger & appetite assessment), body temperature, activity, sleep duration, number of awakenings, nap frequency and duration, metabolic rate assessment, salivary cortisol determinations, fasting glucose, and analysis of their gut microbiota (short-chain fatty acids from fecal samples).The study found that the 19 postmenopausal participants did not gain body weight with the chocolate intake. In fact, comment the investigators, “while the volunteers had an increase of energy intake due to chocolate's extra calories (extra 542 kcal), as compared to the non-chocolate condition, they spontaneously reduced their ad libitum energy intake by 16%, when eating chocolate in the morning.”This situation occurred even though the females consumed milk chocolate that has been shown to have less of an effect in decreasing appetite than dark chocolate.Further stated, “results show that when eating chocolate, females were less hungry and had less desire for sweets than with no chocolate, especially when taking chocolate during the evening/night. Moreover, daily cortisol levels were lower when eating chocolate in the morning than at evening/night.”  Read the rest at MaxWellNutrition.com. 

This podcast covers the JBJS June 16, 2021 issue. Featured are articles covering Volumetric Bone Mineral Density in Cementless Total Hip Arthroplasty in Postmenopausal Women; recorded commentary by Dr. Blaha; Length of Stay, Readmissions, Complications in Unicompartmental Versus Total Knee Arthroplasty.

Tune in to learn about all the benefits of this adaptogen; Maca! More than two centuries ago, Peruvians discovered that a tuberous vegetable growing high in the Andes mountain range had some noticeable benefits for their health and endurance. Men going into battle or performing other physical feats would take maca because they observed that it gave them stamina, strength, and virility. Meanwhile, women who consumed maca had better reproductive health, energy, and focus. Loads of benefits in this root!  What Is Maca?  Growing at an elevation of 12-14,000 feet above sea level in the Andes mountains of Peru, maca grows in extreme weather conditions. Thriving in a habitat of intense sunlight, cold temperatures, and strong winds, this tuberous plant is a part of the brassica family. Just like cauliflower, broccoli, and cabbage, maca is a cruciferous vegetable.  Nutrients Found in Maca  Maca contains plenty of healthy fatty acids, the most abundant being linoleic, oleic, and palmitic acids. Maca contains vitamins A, C, B2, B6, and niacin, as well as minerals – zinc, iron, iodine, copper, calcium, potassium, and magnesium. Nine amino acids are considered essential for optimal health, and maca contains seven of them [1].  Maca is also a rich source of plant sterols, which are part of what makes it so beneficial for hormonal health. Plant sterols are (chemically speaking) structurally similar to the body’s own hormones such as estrogen, progesterone, and testosterone.  Maca Is an Adaptogen  So how exactly does it work? Maca is an adaptogen, meaning that it works to strengthen, balance, and help the body respond to internal and external changes and stressors. It regulates the production of hormones to maintain healthy organ function. Maca feeds the hypothalamus, pituitary, and adrenal glands, known as the Master Glands (more on that later).  Maca’s plant sterols appear to stimulate changes in the action of the hypothalamus, pituitary, and adrenal glands. Maca also seems to exert an influence on the ovaries, pineal gland, and thyroid.  How Maca Can Aid Fluctuating Hormones  Premenstrual Syndrome (PMS) is one of the most common complaints among women of reproductive age. When out of balance, estrogen – the hormone responsible for regulating the reproductive system – can cause a wide range of symptoms and annoyances for women (and their men!).  Mood swings, water retention, fatigue, food cravings, irritability, headaches, irregular menstrual periods, painful cramping… all can be attributable to estrogen imbalance.  Maca can help ease the rapid rise and fall of hormones in menstruating women due to its adaptogenic properties. Also, by improving the connection between the brain and the pituitary gland, maca’s ability to help balance levels of circulating hormones is further enhanced. Most PMS sufferers taking maca report a marked improvement in symptoms during their first menstrual period after commencement of maca.  Other times when maca may be of benefit to women is after coming off birth control pills, and after having a baby and breastfeeding has ceased. At such times, endocrine system function can be depleted, and maca’s adaptogenic properties mean it can help the body right itself again.    Maca can also ease many of the symptoms of perimenopause and menopause. For those harried by hot flashes, night sweats, insomnia, depression, anxiety, and lack of energy, maca can provide some much-needed relief. Maca does not appear to mimic estrogen in the body but it can help to increase the body’s production of estrogen if levels are too low. That’s the beauty of an adaptogenic herb: it adapts to what the body needs.  In a 2006 clinical trial, 34 early-postmenopausal women were given a supplement containing either maca or a placebo twice per day for four months. Those receiving the maca had increased levels of estrogen, suppressed levels of FSH, T3 thyroid hormone, adrenocorticotropic hormone, and cortisol (the hormone secreted in response to stress). Body mass index also decreased. Iron levels increased, however, as did bone density markers, and maca relieved many of the symptoms of menopausal discomfort such as hot flashes and night sweats [2].  Another small 2014 clinical study found that maca reduced blood pressure and depression in postmenopausal women [3].  Can Maca Can Also Benefit Men?  Maca can also be helpful for male health. Recent studies have indicated that maca may assist male health by helping to increase sperm count and motility, increasing sexual desire, protecting the prostate and reducing the incidence of benign prostatic hyperplasia, reducing stress and depression, boosting energy levels, and easing mild erectile dysfunction [1, 4].  8 Additional Health Benefits of Maca  #1. Boosts Energy and Endurance  A 2009 study of male cyclists found that maca supplementation did indeed improve cycling time performance, as well as sexual desire (a perk for many) [5].  #2. Hypothalamus/Pituitary/Adrenal (HPA) Gland Nourishment  HPA glands are called the “Master Glands” because they regulate other glands (you may also hear it termed the “HPA Axis”). When HPA is well nourished, other glands of the body benefit as well. When under stress, the adrenal gland takes a big hit, especially if the stress moves from acute (short-lasting stress) to chronic (long-lasting stress).  Maca feeds all three glands by supporting the body’s production of hormones, either increasing or decreasing levels according to the need. As a result, maca may help prevent or repair adrenal exhaustion and all of the unhealthy follow-on effects this has on the body and mind.  #3. Libido Booster  Maca has been used traditionally by Peruvians to boost virility and libido. Science has not yet determined how maca does this, but it has been called “Nature’s Viagra” for good reason.  Some health experts believe maca’s effects on libido may be caused by its long-chain fatty acids known as macaenes and macamides, which are unique and have not been found in any other plant.  A 2008 clinical study followed women suffering from sexual dysfunction caused by selective serotonin reuptake inhibitors (SSRIs) for depression. The study found that three grams of maca per day gave significant improvement in libido for the women taking it [6].  #4. Cardiovascular Health  Maca’s phytosterols – campesteroland beta-sitosterol, act to interfere with the absorption of LDL cholesterol (the so-called “bad” cholesterol), making maca beneficial for the cardiovascular system [7]. Phytosterols have also been studied for their anti-inflammatory effects, which assist in balancing the immune system, and, as an added bonus, help to protect the body from abnormal cell growth.  #5. Anti-Cancer  A 2015 study found that phytosterols interfere with many different pathways in the carcinogenesis (cancer beginning) process [8]. In addition, an animal study found that beta-sitosterol decreased levels of circulating estrogen and inhibited the growth of estrogen-receptor positive breast cancer tumors [9].  #6. Boosts Immunity  The phytosterols in maca stimulate the immune system and increased levels of interleukin-2 and natural killer cells [7] which the body needs to fight abnormal cell growth.  #7. Liver Support  Being a cruciferous vegetable, maca contains glucosinolates which, when chewed and digested, change into health-promoting chemicals that help protect against cancer. Sulfur-containing glucosinolates form bonds that help the body’s enzymes do their work better.  Both sulfur and plant sterols are required in the production of a master antioxidant called glutathione which boosts liver function and helps the liver with detoxification [10].  #8. Healthy Bones  Maca’s vitamins and minerals can help to build strong, healthy bones. A 2006 clinical trial found that maca increased bone density markers for the early-postmenopausal women taking it [2].  How to Take Maca  Look for organic maca powder grown in Peru. Maca can be added to juices, oatmeal, inside sandwiches, sprinkled on salads, and added to raw food recipes. Just keep in mind that it is best not to heat maca powder to high temperatures which might diminish some of its nutrients. If you use it in recipes, add it after cooking, just before serving.  A gentle approach is generally the best way to begin taking maca.  Recommendations are to start with a small dose of 1 teaspoon per day. If that is well tolerated, gradually increase the dose to 1 tablespoon, or more. If you haven’t noticed any improvement, remember one trial had women taking 3 grams per day.  It can take two or three weeks before you may notice the full benefits of maca. It is also recommended to only take maca daily for a few months and then take a break from it for a month or so before resuming consumption again.  Some health experts recommend avoiding maca under the following conditions. Please consult with your own healthcare provider if:  you are between the ages of 15 and 35, have a good, mainly plant-based diet, and don’t have mood swings, fluid retention, or any of the symptoms of PMS  you have an allergy to iodine  you have Hashimoto’s disease or hyperthyroid condition  If hormonal fluctuations are creating havoc in your life, consult your natural health practitioner to see if maca might be right for you.      RESOURCES  Organixx’s E-Plexx  https://shop.organixx.com/collections/all-products/products/e-plexx?gl=5d88ed1102e26b6546380837    16 Signs & Symptoms of Menopause Every Woman Needs to Know (& What to Do About Them!)  https://organixx.com/signs-symptoms-menopause/    Healthy Maca Cacao Pie  https://organixx.com/maca-cacao-pie-recipe/  [1] Ethnobiology and Ethnopharmacology of Lepidium Meyenii (Maca), a Plant from the Peruvian Highlands  [2] Hormone-Balancing Effect of Pre-Gelatinized Organic Maca (Lepidium peruvianum Chacon): (III) Clinical Responses of Early-postmenopausal Women to Maca in Double Blind, Randomized, Placebo-controlled, Crossover Configuration, Outpatient Study  [3] Maca Reduces Blood Pressure and Depression, in a Pilot Study in Postmenopausal Women  [4] Lepidium Meyenii (Maca) Improved Semen Parameters in Adult Men  [5] A Pilot Investigation into the Effect of Maca Supplementation on Physical Activity and Sexual Desire in Sportsmen  [6] A Double-blind, Randomized, Pilot Dose-finding Study of Maca Root (L. Meyenii) for the Management of SSRI-induced Sexual Dysfunction  [7] Plant Sterols as Anticancer Nutrients: Evidence for Their Role in Breast  [8] Beta-Sitosterol: A Promising but Orphan Nutraceutical to Fight Against  [9] Beta-Sitosterol, Beta-Sitosterol Glucoside, and a Mixture of Beta-Sitosterol and Beta-Sitosterol Glucoside Modulate the Growth of Estrogen- Responsive Breast Cancer Cells In Vitro and in Ovariectomized Athymic Mice  [10] Beta-sitosterol Modulates Antioxidant Enzyme Response in Raw 264.7 Macrophages   

Tune in to learn about all the benefits of this adaptogen; Maca! More than two centuries ago, Peruvians discovered that a tuberous vegetable growing high in the Andes mountain range had some noticeable benefits for their health and endurance. Men going into battle or performing other physical feats would take maca because they observed that it gave them stamina, strength, and virility. Meanwhile, women who consumed maca had better reproductive health, energy, and focus. Loads of benefits in this root!   What Is Maca? Growing at an elevation of 12-14,000 feet above sea level in the Andes mountains of Peru, maca grows in extreme weather conditions. Thriving in a habitat of intense sunlight, cold temperatures, and strong winds, this tuberous plant is a part of the brassica family. Just like cauliflower, broccoli, and cabbage, maca is a cruciferous vegetable. Nutrients Found in Maca Maca contains plenty of healthy fatty acids, the most abundant being linoleic, oleic, and palmitic acids. Maca contains vitamins A, C, B2, B6, and niacin, as well as minerals – zinc, iron, iodine, copper, calcium, potassium, and magnesium. Nine amino acids are considered essential for optimal health, and maca contains seven of them [1]. Maca is also a rich source of plant sterols, which are part of what makes it so beneficial for hormonal health. Plant sterols are (chemically speaking) structurally similar to the body’s own hormones such as estrogen, progesterone, and testosterone. Maca Is an Adaptogen So how exactly does it work? Maca is an adaptogen, meaning that it works to strengthen, balance, and help the body respond to internal and external changes and stressors. It regulates the production of hormones to maintain healthy organ function. Maca feeds the hypothalamus, pituitary, and adrenal glands, known as the Master Glands (more on that later). Maca’s plant sterols appear to stimulate changes in the action of the hypothalamus, pituitary, and adrenal glands. Maca also seems to exert an influence on the ovaries, pineal gland, and thyroid. How Maca Can Aid Fluctuating Hormones Premenstrual Syndrome (PMS) is one of the most common complaints among women of reproductive age. When out of balance, estrogen – the hormone responsible for regulating the reproductive system – can cause a wide range of symptoms and annoyances for women (and their men!). Mood swings, water retention, fatigue, food cravings, irritability, headaches, irregular menstrual periods, painful cramping… all can be attributable to estrogen imbalance. Maca can help ease the rapid rise and fall of hormones in menstruating women due to its adaptogenic properties. Also, by improving the connection between the brain and the pituitary gland, maca’s ability to help balance levels of circulating hormones is further enhanced. Most PMS sufferers taking maca report a marked improvement in symptoms during their first menstrual period after commencement of maca. Other times when maca may be of benefit to women is after coming off birth control pills, and after having a baby and breastfeeding has ceased. At such times, endocrine system function can be depleted, and maca’s adaptogenic properties mean it can help the body right itself again. Maca can also ease many of the symptoms of perimenopause and menopause. For those harried by hot flashes, night sweats, insomnia, depression, anxiety, and lack of energy, maca can provide some much-needed relief. Maca does not appear to mimic estrogen in the body but it can help to increase the body’s production of estrogen if levels are too low. That’s the beauty of an adaptogenic herb: it adapts to what the body needs. In a 2006 clinical trial, 34 early-postmenopausal women were given a supplement containing either maca or a placebo twice per day for four months. Those receiving the maca had increased levels of estrogen, suppressed levels of FSH, T3 thyroid hormone, adrenocorticotropic hormone, and cortisol (the hormone secreted in response to stress). Body mass index also decreased. Iron levels increased, however, as did bone density markers, and maca relieved many of the symptoms of menopausal discomfort such as hot flashes and night sweats [2]. Another small 2014 clinical study found that maca reduced blood pressure and depression in postmenopausal women [3]. Can Maca Can Also Benefit Men? Maca can also be helpful for male health. Recent studies have indicated that maca may assist male health by helping to increase sperm count and motility, increasing sexual desire, protecting the prostate and reducing the incidence of benign prostatic hyperplasia, reducing stress and depression, boosting energy levels, and easing mild erectile dysfunction [1, 4]. 8 Additional Health Benefits of Maca #1. Boosts Energy and Endurance A 2009 study of male cyclists found that maca supplementation did indeed improve cycling time performance, as well as sexual desire (a perk for many) [5]. #2. Hypothalamus/Pituitary/Adrenal (HPA) Gland Nourishment HPA glands are called the “Master Glands” because they regulate other glands (you may also hear it termed the “HPA Axis”). When HPA is well nourished, other glands of the body benefit as well. When under stress, the adrenal gland takes a big hit, especially if the stress moves from acute (short-lasting stress) to chronic (long-lasting stress). Maca feeds all three glands by supporting the body’s production of hormones, either increasing or decreasing levels according to the need. As a result, maca may help prevent or repair adrenal exhaustion and all of the unhealthy follow-on effects this has on the body and mind. #3. Libido Booster Maca has been used traditionally by Peruvians to boost virility and libido. Science has not yet determined how maca does this, but it has been called “Nature’s Viagra” for good reason. Some health experts believe maca’s effects on libido may be caused by its long-chain fatty acids known as macaenes and macamides, which are unique and have not been found in any other plant. A 2008 clinical study followed women suffering from sexual dysfunction caused by selective serotonin reuptake inhibitors (SSRIs) for depression. The study found that three grams of maca per day gave significant improvement in libido for the women taking it [6]. #4. Cardiovascular Health Maca’s phytosterols – campesteroland beta-sitosterol, act to interfere with the absorption of LDL cholesterol (the so-called “bad” cholesterol), making maca beneficial for the cardiovascular system [7]. Phytosterols have also been studied for their anti-inflammatory effects, which assist in balancing the immune system, and, as an added bonus, help to protect the body from abnormal cell growth. #5. Anti-Cancer A 2015 study found that phytosterols interfere with many different pathways in the carcinogenesis (cancer beginning) process [8]. In addition, an animal study found that beta-sitosterol decreased levels of circulating estrogen and inhibited the growth of estrogen-receptor positive breast cancer tumors [9]. #6. Boosts Immunity The phytosterols in maca stimulate the immune system and increased levels of interleukin-2 and natural killer cells [7] which the body needs to fight abnormal cell growth. #7. Liver Support Being a cruciferous vegetable, maca contains glucosinolates which, when chewed and digested, change into health-promoting chemicals that help protect against cancer. Sulfur-containing glucosinolates form bonds that help the body’s enzymes do their work better. Both sulfur and plant sterols are required in the production of a master antioxidant called glutathione which boosts liver function and helps the liver with detoxification [10]. #8. Healthy Bones Maca’s vitamins and minerals can help to build strong, healthy bones. A 2006 clinical trial found that maca increased bone density markers for the early-postmenopausal women taking it [2]. How to Take Maca Look for organic maca powder grown in Peru. Maca can be added to juices, oatmeal, inside sandwiches, sprinkled on salads, and added to raw food recipes. Just keep in mind that it is best not to heat maca powder to high temperatures which might diminish some of its nutrients. If you use it in recipes, add it after cooking, just before serving. A gentle approach is generally the best way to begin taking maca. Recommendations are to start with a small dose of 1 teaspoon per day. If that is well tolerated, gradually increase the dose to 1 tablespoon, or more. If you haven’t noticed any improvement, remember one trial had women taking 3 grams per day. It can take two or three weeks before you may notice the full benefits of maca. It is also recommended to only take maca daily for a few months and then take a break from it for a month or so before resuming consumption again. Some health experts recommend avoiding maca under the following conditions. Please consult with your own healthcare provider if: you are between the ages of 15 and 35, have a good, mainly plant-based diet, and don’t have mood swings, fluid retention, or any of the symptoms of PMS you have an allergy to iodine you have Hashimoto’s disease or hyperthyroid condition If hormonal fluctuations are creating havoc in your life, consult your natural health practitioner to see if maca might be right for you.     RESOURCES Organixx’s E-Plexx https://shop.organixx.com/collections/all-products/products/e-plexx?gl=5d88ed1102e26b6546380837   16 Signs & Symptoms of Menopause Every Woman Needs to Know (& What to Do About Them!) https://organixx.com/signs-symptoms-menopause/   Healthy Maca Cacao Pie https://organixx.com/maca-cacao-pie-recipe/ [1] Ethnobiology and Ethnopharmacology of Lepidium Meyenii (Maca), a Plant from the Peruvian Highlands [2] Hormone-Balancing Effect of Pre-Gelatinized Organic Maca (Lepidium peruvianum Chacon): (III) Clinical Responses of Early-postmenopausal Women to Maca in Double Blind, Randomized, Placebo-controlled, Crossover Configuration, Outpatient Study [3] Maca Reduces Blood Pressure and Depression, in a Pilot Study in Postmenopausal Women [4] Lepidium Meyenii (Maca) Improved Semen Parameters in Adult Men [5] A Pilot Investigation into the Effect of Maca Supplementation on Physical Activity and Sexual Desire in Sportsmen [6] A Double-blind, Randomized, Pilot Dose-finding Study of Maca Root (L. Meyenii) for the Management of SSRI-induced Sexual Dysfunction [7] Plant Sterols as Anticancer Nutrients: Evidence for Their Role in Breast [8] Beta-Sitosterol: A Promising but Orphan Nutraceutical to Fight Against [9] Beta-Sitosterol, Beta-Sitosterol Glucoside, and a Mixture of Beta-Sitosterol and Beta-Sitosterol Glucoside Modulate the Growth of Estrogen- Responsive Breast Cancer Cells In Vitro and in Ovariectomized Athymic Mice [10] Beta-sitosterol Modulates Antioxidant Enzyme Response in Raw 264.7 Macrophages Subscribe to Empowering You Organically  Never miss an episode!    APPLE PODCASTS                 SPOTIFY                 GOOGLE PODCASTS

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Tune in to learn about all the benefits of this adaptogen; Maca! More than two centuries ago, Peruvians discovered that a tuberous vegetable growing high in the Andes mountain range had some noticeable benefits for their health and endurance. Men going into battle or performing other physical feats would take maca because they observed that it gave them stamina, strength, and virility. Meanwhile, women who consumed maca had better reproductive health, energy, and focus. Loads of benefits in this root! What Is Maca? Growing at an elevation of 12-14,000 feet above sea level in the Andes mountains of Peru, maca grows in extreme weather conditions. Thriving in a habitat of intense sunlight, cold temperatures, and strong winds, this tuberous plant is a part of the brassica family. Just like cauliflower, broccoli, and cabbage, maca is a cruciferous vegetable. Nutrients Found in Maca Maca contains plenty of healthy fatty acids, the most abundant being linoleic, oleic, and palmitic acids. Maca contains vitamins A, C, B2, B6, and niacin, as well as minerals – zinc, iron, iodine, copper, calcium, potassium, and magnesium. Nine amino acids are considered essential for optimal health, and maca contains seven of them [1]. Maca is also a rich source of plant sterols, which are part of what makes it so beneficial for hormonal health. Plant sterols are (chemically speaking) structurally similar to the body’s own hormones such as estrogen, progesterone, and testosterone. Maca Is an Adaptogen So how exactly does it work? Maca is an adaptogen, meaning that it works to strengthen, balance, and help the body respond to internal and external changes and stressors. It regulates the production of hormones to maintain healthy organ function. Maca feeds the hypothalamus, pituitary, and adrenal glands, known as the Master Glands (more on that later). Maca’s plant sterols appear to stimulate changes in the action of the hypothalamus, pituitary, and adrenal glands. Maca also seems to exert an influence on the ovaries, pineal gland, and thyroid. How Maca Can Aid Fluctuating Hormones Premenstrual Syndrome (PMS) is one of the most common complaints among women of reproductive age. When out of balance, estrogen – the hormone responsible for regulating the reproductive system – can cause a wide range of symptoms and annoyances for women (and their men!). Mood swings, water retention, fatigue, food cravings, irritability, headaches, irregular menstrual periods, painful cramping… all can be attributable to estrogen imbalance. Maca can help ease the rapid rise and fall of hormones in menstruating women due to its adaptogenic properties. Also, by improving the connection between the brain and the pituitary gland, maca’s ability to help balance levels of circulating hormones is further enhanced. Most PMS sufferers taking maca report a marked improvement in symptoms during their first menstrual period after commencement of maca. Other times when maca may be of benefit to women is after coming off birth control pills, and after having a baby and breastfeeding has ceased. At such times, endocrine system function can be depleted, and maca’s adaptogenic properties mean it can help the body right itself again. Maca can also ease many of the symptoms of perimenopause and menopause. For those harried by hot flashes, night sweats, insomnia, depression, anxiety, and lack of energy, maca can provide some much-needed relief. Maca does not appear to mimic estrogen in the body but it can help to increase the body’s production of estrogen if levels are too low. That’s the beauty of an adaptogenic herb: it adapts to what the body needs. In a 2006 clinical trial, 34 early-postmenopausal women were given a supplement containing either maca or a placebo twice per day for four months. Those receiving the maca had increased levels of estrogen, suppressed levels of FSH, T3 thyroid hormone, adrenocorticotropic hormone, and cortisol (the hormone secreted in response to stress). Body mass index also decreased. Iron levels increased, however, as did bone density markers, and maca relieved many of the symptoms of menopausal discomfort such as hot flashes and night sweats [2]. Another small 2014 clinical study found that maca reduced blood pressure and depression in postmenopausal women [3]. Can Maca Can Also Benefit Men? Maca can also be helpful for male health. Recent studies have indicated that maca may assist male health by helping to increase sperm count and motility, increasing sexual desire, protecting the prostate and reducing the incidence of benign prostatic hyperplasia, reducing stress and depression, boosting energy levels, and easing mild erectile dysfunction [1, 4]. 8 Additional Health Benefits of Maca #1. Boosts Energy and Endurance A 2009 study of male cyclists found that maca supplementation did indeed improve cycling time performance, as well as sexual desire (a perk for many) [5]. #2. Hypothalamus/Pituitary/Adrenal (HPA) Gland Nourishment HPA glands are called the “Master Glands” because they regulate other glands (you may also hear it termed the “HPA Axis”). When HPA is well nourished, other glands of the body benefit as well. When under stress, the adrenal gland takes a big hit, especially if the stress moves from acute (short-lasting stress) to chronic (long-lasting stress). Maca feeds all three glands by supporting the body’s production of hormones, either increasing or decreasing levels according to the need. As a result, maca may help prevent or repair adrenal exhaustion and all of the unhealthy follow-on effects this has on the body and mind. #3. Libido Booster Maca has been used traditionally by Peruvians to boost virility and libido. Science has not yet determined how maca does this, but it has been called “Nature’s Viagra” for good reason. Some health experts believe maca’s effects on libido may be caused by its long-chain fatty acids known as macaenes and macamides, which are unique and have not been found in any other plant. A 2008 clinical study followed women suffering from sexual dysfunction caused by selective serotonin reuptake inhibitors (SSRIs) for depression. The study found that three grams of maca per day gave significant improvement in libido for the women taking it [6]. #4. Cardiovascular Health Maca’s phytosterols – campesteroland beta-sitosterol, act to interfere with the absorption of LDL cholesterol (the so-called “bad” cholesterol), making maca beneficial for the cardiovascular system [7]. Phytosterols have also been studied for their anti-inflammatory effects, which assist in balancing the immune system, and, as an added bonus, help to protect the body from abnormal cell growth. #5. Anti-Cancer A 2015 study found that phytosterols interfere with many different pathways in the carcinogenesis (cancer beginning) process [8]. In addition, an animal study found that beta-sitosterol decreased levels of circulating estrogen and inhibited the growth of estrogen-receptor positive breast cancer tumors [9]. #6. Boosts Immunity The phytosterols in maca stimulate the immune system and increased levels of interleukin-2 and natural killer cells [7] which the body needs to fight abnormal cell growth. #7. Liver Support Being a cruciferous vegetable, maca contains glucosinolates which, when chewed and digested, change into health-promoting chemicals that help protect against cancer. Sulfur-containing glucosinolates form bonds that help the body’s enzymes do their work better. Both sulfur and plant sterols are required in the production of a master antioxidant called glutathione which boosts liver function and helps the liver with detoxification [10]. #8. Healthy Bones Maca’s vitamins and minerals can help to build strong, healthy bones. A 2006 clinical trial found that maca increased bone density markers for the early-postmenopausal women taking it [2]. How to Take Maca Look for organic maca powder grown in Peru. Maca can be added to juices, oatmeal, inside sandwiches, sprinkled on salads, and added to raw food recipes. Just keep in mind that it is best not to heat maca powder to high temperatures which might diminish some of its nutrients. If you use it in recipes, add it after cooking, just before serving. A gentle approach is generally the best way to begin taking maca. Recommendations are to start with a small dose of 1 teaspoon per day. If that is well tolerated, gradually increase the dose to 1 tablespoon, or more. If you haven’t noticed any improvement, remember one trial had women taking 3 grams per day. It can take two or three weeks before you may notice the full benefits of maca. It is also recommended to only take maca daily for a few months and then take a break from it for a month or so before resuming consumption again. Some health experts recommend avoiding maca under the following conditions. Please consult with your own healthcare provider if: you are between the ages of 15 and 35, have a good, mainly plant-based diet, and don’t have mood swings, fluid retention, or any of the symptoms of PMS you have an allergy to iodine you have Hashimoto’s disease or hyperthyroid condition If hormonal fluctuations are creating havoc in your life, consult your natural health practitioner to see if maca might be right for you.     RESOURCES Organixx’s E-Plexx https://shop.organixx.com/collections/all-products/products/e-plexx?gl=5d88ed1102e26b6546380837   16 Signs & Symptoms of Menopause Every Woman Needs to Know (& What to Do About Them!) https://organixx.com/signs-symptoms-menopause/   Healthy Maca Cacao Pie https://organixx.com/maca-cacao-pie-recipe/ [1] Ethnobiology and Ethnopharmacology of Lepidium Meyenii (Maca), a Plant from the Peruvian Highlands [2] Hormone-Balancing Effect of Pre-Gelatinized Organic Maca (Lepidium peruvianum Chacon): (III) Clinical Responses of Early-postmenopausal Women to Maca in Double Blind, Randomized, Placebo-controlled, Crossover Configuration, Outpatient Study [3] Maca Reduces Blood Pressure and Depression, in a Pilot Study in Postmenopausal Women [4] Lepidium Meyenii (Maca) Improved Semen Parameters in Adult Men [5] A Pilot Investigation into the Effect of Maca Supplementation on Physical Activity and Sexual Desire in Sportsmen [6] A Double-blind, Randomized, Pilot Dose-finding Study of Maca Root (L. Meyenii) for the Management of SSRI-induced Sexual Dysfunction [7] Plant Sterols as Anticancer Nutrients: Evidence for Their Role in Breast [8] Beta-Sitosterol: A Promising but Orphan Nutraceutical to Fight Against [9] Beta-Sitosterol, Beta-Sitosterol Glucoside, and a Mixture of Beta-Sitosterol and Beta-Sitosterol Glucoside Modulate the Growth of Estrogen- Responsive Breast Cancer Cells In Vitro and in Ovariectomized Athymic Mice [10] Beta-sitosterol Modulates Antioxidant Enzyme Response in Raw 264.7 Macrophages

Tune in to learn about all the benefits of this adaptogen; Maca! More than two centuries ago, Peruvians discovered that a tuberous vegetable growing high in the Andes mountain range had some noticeable benefits for their health and endurance. Men going into battle or performing other physical feats would take maca because they observed that it gave them stamina, strength, and virility. Meanwhile, women who consumed maca had better reproductive health, energy, and focus. Loads of benefits in this root! What Is Maca? Growing at an elevation of 12-14,000 feet above sea level in the Andes mountains of Peru, maca grows in extreme weather conditions. Thriving in a habitat of intense sunlight, cold temperatures, and strong winds, this tuberous plant is a part of the brassica family. Just like cauliflower, broccoli, and cabbage, maca is a cruciferous vegetable. Nutrients Found in Maca Maca contains plenty of healthy fatty acids, the most abundant being linoleic, oleic, and palmitic acids. Maca contains vitamins A, C, B2, B6, and niacin, as well as minerals – zinc, iron, iodine, copper, calcium, potassium, and magnesium. Nine amino acids are considered essential for optimal health, and maca contains seven of them [1]. Maca is also a rich source of plant sterols, which are part of what makes it so beneficial for hormonal health. Plant sterols are (chemically speaking) structurally similar to the body’s own hormones such as estrogen, progesterone, and testosterone. Maca Is an Adaptogen So how exactly does it work? Maca is an adaptogen, meaning that it works to strengthen, balance, and help the body respond to internal and external changes and stressors. It regulates the production of hormones to maintain healthy organ function. Maca feeds the hypothalamus, pituitary, and adrenal glands, known as the Master Glands (more on that later). Maca’s plant sterols appear to stimulate changes in the action of the hypothalamus, pituitary, and adrenal glands. Maca also seems to exert an influence on the ovaries, pineal gland, and thyroid. How Maca Can Aid Fluctuating Hormones Premenstrual Syndrome (PMS) is one of the most common complaints among women of reproductive age. When out of balance, estrogen – the hormone responsible for regulating the reproductive system – can cause a wide range of symptoms and annoyances for women (and their men!). Mood swings, water retention, fatigue, food cravings, irritability, headaches, irregular menstrual periods, painful cramping… all can be attributable to estrogen imbalance. Maca can help ease the rapid rise and fall of hormones in menstruating women due to its adaptogenic properties. Also, by improving the connection between the brain and the pituitary gland, maca’s ability to help balance levels of circulating hormones is further enhanced. Most PMS sufferers taking maca report a marked improvement in symptoms during their first menstrual period after commencement of maca. Other times when maca may be of benefit to women is after coming off birth control pills, and after having a baby and breastfeeding has ceased. At such times, endocrine system function can be depleted, and maca’s adaptogenic properties mean it can help the body right itself again. Maca can also ease many of the symptoms of perimenopause and menopause. For those harried by hot flashes, night sweats, insomnia, depression, anxiety, and lack of energy, maca can provide some much-needed relief. Maca does not appear to mimic estrogen in the body but it can help to increase the body’s production of estrogen if levels are too low. That’s the beauty of an adaptogenic herb: it adapts to what the body needs. In a 2006 clinical trial, 34 early-postmenopausal women were given a supplement containing either maca or a placebo twice per day for four months. Those receiving the maca had increased levels of estrogen, suppressed levels of FSH, T3 thyroid hormone, adrenocorticotropic hormone, and cortisol (the hormone secreted in response to stress). Body mass index also decreased. Iron levels increased, however, as did bone density markers, and maca relieved many of the symptoms of menopausal discomfort such as hot flashes and night sweats [2]. Another small 2014 clinical study found that maca reduced blood pressure and depression in postmenopausal women [3]. Can Maca Can Also Benefit Men? Maca can also be helpful for male health. Recent studies have indicated that maca may assist male health by helping to increase sperm count and motility, increasing sexual desire, protecting the prostate and reducing the incidence of benign prostatic hyperplasia, reducing stress and depression, boosting energy levels, and easing mild erectile dysfunction [1, 4]. 8 Additional Health Benefits of Maca #1. Boosts Energy and Endurance A 2009 study of male cyclists found that maca supplementation did indeed improve cycling time performance, as well as sexual desire (a perk for many) [5]. #2. Hypothalamus/Pituitary/Adrenal (HPA) Gland Nourishment HPA glands are called the “Master Glands” because they regulate other glands (you may also hear it termed the “HPA Axis”). When HPA is well nourished, other glands of the body benefit as well. When under stress, the adrenal gland takes a big hit, especially if the stress moves from acute (short-lasting stress) to chronic (long-lasting stress). Maca feeds all three glands by supporting the body’s production of hormones, either increasing or decreasing levels according to the need. As a result, maca may help prevent or repair adrenal exhaustion and all of the unhealthy follow-on effects this has on the body and mind. #3. Libido Booster Maca has been used traditionally by Peruvians to boost virility and libido. Science has not yet determined how maca does this, but it has been called “Nature’s Viagra” for good reason. Some health experts believe maca’s effects on libido may be caused by its long-chain fatty acids known as macaenes and macamides, which are unique and have not been found in any other plant. A 2008 clinical study followed women suffering from sexual dysfunction caused by selective serotonin reuptake inhibitors (SSRIs) for depression. The study found that three grams of maca per day gave significant improvement in libido for the women taking it [6]. #4. Cardiovascular Health Maca’s phytosterols – campesteroland beta-sitosterol, act to interfere with the absorption of LDL cholesterol (the so-called “bad” cholesterol), making maca beneficial for the cardiovascular system [7]. Phytosterols have also been studied for their anti-inflammatory effects, which assist in balancing the immune system, and, as an added bonus, help to protect the body from abnormal cell growth. #5. Anti-Cancer A 2015 study found that phytosterols interfere with many different pathways in the carcinogenesis (cancer beginning) process [8]. In addition, an animal study found that beta-sitosterol decreased levels of circulating estrogen and inhibited the growth of estrogen-receptor positive breast cancer tumors [9]. #6. Boosts Immunity The phytosterols in maca stimulate the immune system and increased levels of interleukin-2 and natural killer cells [7] which the body needs to fight abnormal cell growth. #7. Liver Support Being a cruciferous vegetable, maca contains glucosinolates which, when chewed and digested, change into health-promoting chemicals that help protect against cancer. Sulfur-containing glucosinolates form bonds that help the body’s enzymes do their work better. Both sulfur and plant sterols are required in the production of a master antioxidant called glutathione which boosts liver function and helps the liver with detoxification [10]. #8. Healthy Bones Maca’s vitamins and minerals can help to build strong, healthy bones. A 2006 clinical trial found that maca increased bone density markers for the early-postmenopausal women taking it [2]. How to Take Maca Look for organic maca powder grown in Peru. Maca can be added to juices, oatmeal, inside sandwiches, sprinkled on salads, and added to raw food recipes. Just keep in mind that it is best not to heat maca powder to high temperatures which might diminish some of its nutrients. If you use it in recipes, add it after cooking, just before serving. A gentle approach is generally the best way to begin taking maca. Recommendations are to start with a small dose of 1 teaspoon per day. If that is well tolerated, gradually increase the dose to 1 tablespoon, or more. If you haven’t noticed any improvement, remember one trial had women taking 3 grams per day. It can take two or three weeks before you may notice the full benefits of maca. It is also recommended to only take maca daily for a few months and then take a break from it for a month or so before resuming consumption again. Some health experts recommend avoiding maca under the following conditions. Please consult with your own healthcare provider if: you are between the ages of 15 and 35, have a good, mainly plant-based diet, and don’t have mood swings, fluid retention, or any of the symptoms of PMS you have an allergy to iodine you have Hashimoto’s disease or hyperthyroid condition If hormonal fluctuations are creating havoc in your life, consult your natural health practitioner to see if maca might be right for you.     RESOURCES Organixx’s E-Plexx https://shop.organixx.com/collections/all-products/products/e-plexx?gl=5d88ed1102e26b6546380837   16 Signs & Symptoms of Menopause Every Woman Needs to Know (& What to Do About Them!) https://organixx.com/signs-symptoms-menopause/   Healthy Maca Cacao Pie https://organixx.com/maca-cacao-pie-recipe/ [1] Ethnobiology and Ethnopharmacology of Lepidium Meyenii (Maca), a Plant from the Peruvian Highlands [2] Hormone-Balancing Effect of Pre-Gelatinized Organic Maca (Lepidium peruvianum Chacon): (III) Clinical Responses of Early-postmenopausal Women to Maca in Double Blind, Randomized, Placebo-controlled, Crossover Configuration, Outpatient Study [3] Maca Reduces Blood Pressure and Depression, in a Pilot Study in Postmenopausal Women [4] Lepidium Meyenii (Maca) Improved Semen Parameters in Adult Men [5] A Pilot Investigation into the Effect of Maca Supplementation on Physical Activity and Sexual Desire in Sportsmen [6] A Double-blind, Randomized, Pilot Dose-finding Study of Maca Root (L. Meyenii) for the Management of SSRI-induced Sexual Dysfunction [7] Plant Sterols as Anticancer Nutrients: Evidence for Their Role in Breast [8] Beta-Sitosterol: A Promising but Orphan Nutraceutical to Fight Against [9] Beta-Sitosterol, Beta-Sitosterol Glucoside, and a Mixture of Beta-Sitosterol and Beta-Sitosterol Glucoside Modulate the Growth of Estrogen- Responsive Breast Cancer Cells In Vitro and in Ovariectomized Athymic Mice [10] Beta-sitosterol Modulates Antioxidant Enzyme Response in Raw 264.7 Macrophages

WOMEN AND HEART DISEASE | 4 SURPRISING LINKS BETWEEN ESTROGEN, MENOPAUSE, AND HEART DISEASE. Did you know that estrogen has a protective effect against heart disease, insulin resistance, and so much more? A woman is at a lower risk for heart disease prior to menopause compared with men, but the risk for heart disease between men and women even out after menopause. This video explains why going through menopause and experiencing declining estrogen increases a woman’s risk for cardiovascular disease. CoachingIf you’re ready to lose the weight for good, you’ve come to the right place!Join my online course, Weight Loss for Health, to learn the science behind weight loss and habit change so you can lose weight, get healthy, and prevent disease. Also included with the program are weekly office hours with me and a membership site for encouragement, accountability, and support from other members. To learn more, go to https://www.weightlossforhealth.com/join.Free Weight Loss ResourcesWeight Loss Masterclass to Lower Insulin Resistance & InflammationThe 5% Mindset | How to Win at Weight LossThe Ultimate Food Guide | What to Eat to Burn FatConnect on Social>> Subscribe to My YouTube Channel>> Like My Facebook Page>> Follow Me on Instagram>> Connect on LinkedIn>> View My WebsiteSubscribe & Review in Apple PodcastsAre you subscribed to my podcast? If you’re not, I want to encourage you to do that today. I don’t want you to miss an episode. Click here to subscribe in Apple Podcasts.Now if you’re feeling extra loving, I would be really grateful if you left me a review over on Apple Podcasts, too. Those reviews help other people find my podcast and they’re also fun for me to go in and read. Just click here to review, select “Ratings and Reviews” and “Write a Review” and let me know what your favorite part of the podcast is. Thank you!

Talk to a Dr. Berg Keto Consultant today and get the help you need on your journey (free consultation). Call 1-540-299-1557 with your questions about Keto, Intermittent Fasting, or the use of Dr. Berg products. Consultants are available Monday through Friday from 8 AM to 10 PM EST. Saturday & Sunday from 9 AM to 6 PM EST. USA Only. Get Dr. Berg's Veggie Solution today! • Flavored (Sweetened) - http://bit.ly/3nHbNTs • Plain (Unflavored) - http://bit.ly/3as0x9U Take Dr. Berg's Free Keto Mini-Course! What are the hidden causes of hot flashes? It might just be your liver! Here's why. How to Reduce Cortisol: https://www.youtube.com/watch?v=L2fKo... DATA: Moderate to Severe Vasomotor Symptoms Are Risk Factors for Non-Alcoholic Fatty Liver Disease in Postmenopausal Women https://pubmed.ncbi.nlm.nih.gov/30314... Factors That May Influence the Experience of Hot Flushes by Healthy Middle-Aged Women https://www.ncbi.nlm.nih.gov/pmc/arti... Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. Dr. Berg's Website: http://bit.ly/37AV0fk Dr. Berg's Recipe Ideas: http://bit.ly/37FF6QR Dr. Berg's Reviews: http://bit.ly/3hkIvbb Dr. Berg's Shop: http://bit.ly/3mJcLxg Dr. Berg's Bio: http://bit.ly/3as2cfE Dr. Berg's Health Coach Training: http://bit.ly/3as2p2q Facebook: https://www.facebook.com/drericberg Messenger: https://www.messenger.com/t/drericberg Twitter: https://twitter.com/DrBergDC Instagram: https://www.instagram.com/drericberg/ YouTube: http://bit.ly/37DXt8C

Question: Do postmenopausal women need to worry about iron overload?Generally, it's not men who are necessarily predisposed to iron buildup. It’s men with some genetic predisposition to that, so maybe less than 10% of men. But yeah, postmenopausal women with the same genetics will, like men, be vulnerable to that. When you stop menstruating, you essentially become like a man in terms of your ability to accumulate iron.  If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. For the remainder of 2020, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.  

Commentary by Dr. Greg Hundley

Interview with Nisha I. Parikh, MD, MPH, author of Association of Adverse Pregnancy Outcomes With Risk of Atherosclerotic Cardiovascular Disease in Postmenopausal Women, and C Noel Bairey Merz, MD,  author of Can We Improve Cardiovascular Disease for Women Using Data Under Our Noses?: A Need for Changes in Policy and Focus

Interview with Nisha I. Parikh, MD, MPH, author of Association of Adverse Pregnancy Outcomes With Risk of Atherosclerotic Cardiovascular Disease in Postmenopausal Women, and C Noel Bairey Merz, MD, author of Can We Improve Cardiovascular Disease for Women Using Data Under Our Noses?: A Need for Changes in Policy and Focus

What Is Maca? Growing at an elevation of 12-14,000 feet above sea level in the Andes mountains of Peru, maca grows in extreme weather conditions. Thriving in a habitat of intense sunlight, cold temperatures, and strong winds, this tuberous plant is a part of the brassica family. Just like cauliflower, broccoli, and cabbage, maca is a cruciferous vegetable. Nutrients Found in Maca Maca contains plenty of healthy fatty acids, the most abundant being linoleic, oleic, and palmitic acids. Maca contains vitamins A, C, B2, B6, and niacin, as well as minerals – zinc, iron, iodine, copper, calcium, potassium, and magnesium. Nine amino acids are considered essential for optimal health, and maca contains seven of them [1]. Maca is also a rich source of plant sterols, which are part of what makes it so beneficial for hormonal health. Plant sterols are (chemically speaking) structurally similar to the body’s own hormones such as estrogen, progesterone, and testosterone. Maca Is an Adaptogen So how exactly does it work? Maca is an adaptogen, meaning that it works to strengthen, balance, and help the body respond to internal and external changes and stressors. It regulates the production of hormones to maintain healthy organ function. Maca feeds the hypothalamus, pituitary, and adrenal glands, known as the Master Glands (more on that later). Maca’s plant sterols appear to stimulate changes in the action of the hypothalamus, pituitary, and adrenal glands. Maca also seems to exert an influence on the ovaries, pineal gland, and thyroid. How Maca Can Aid Fluctuating Hormones Premenstrual Syndrome (PMS) is one of the most common complaints among women of reproductive age. When out of balance, estrogen – the hormone responsible for regulating the reproductive system – can cause a wide range of symptoms and annoyances for women (and their men!). Mood swings, water retention, fatigue, food cravings, irritability, headaches, irregular menstrual periods, painful cramping… all can be attributable to estrogen imbalance. Maca can help ease the rapid rise and fall of hormones in menstruating women due to its adaptogenic properties. Also, by improving the connection between the brain and the pituitary gland, maca’s ability to help balance levels of circulating hormones is further enhanced. Most PMS sufferers taking maca report a marked improvement in symptoms during their first menstrual period after commencement of maca. Other times when maca may be of benefit to women is after coming off birth control pills, and after having a baby and breastfeeding has ceased. At such times, endocrine system function can be depleted, and maca’s adaptogenic properties mean it can help the body right itself again. Maca can also ease many of the symptoms of perimenopause and menopause. For those harried by hot flashes, night sweats, insomnia, depression, anxiety, and lack of energy, maca can provide some much-needed relief. Maca does not appear to mimic estrogen in the body but it can help to increase the body’s production of estrogen if levels are too low. That’s the beauty of an adaptogenic herb: it adapts to what the body needs. In a 2006 clinical trial, 34 early-postmenopausal women were given a supplement containing either maca or a placebo twice per day for four months. Those receiving the maca had increased levels of estrogen, suppressed levels of FSH, T3 thyroid hormone, adrenocorticotropic hormone, and cortisol (the hormone secreted in response to stress). Body mass index also decreased. Iron levels increased, however, as did bone density markers, and maca relieved many of the symptoms of menopausal discomfort such as hot flashes and night sweats [2]. Another small 2014 clinical study found that maca reduced blood pressure and depression in postmenopausal women [3]. Can Maca Can Also Benefit Men? Maca can also be helpful for male health. Recent studies have indicated that maca may assist male health by helping to increase sperm count and motility, increasing sexual desire, protecting the prostate and reducing the incidence of benign prostatic hyperplasia, reducing stress and depression, boosting energy levels, and easing mild erectile dysfunction [1, 4]. 8 Additional Health Benefits of Maca #1. Boosts Energy and Endurance A 2009 study of male cyclists found that maca supplementation did indeed improve cycling time performance, as well as sexual desire (a perk for many) [5]. #2. Hypothalamus/Pituitary/Adrenal (HPA) Gland Nourishment HPA glands are called the “Master Glands” because they regulate other glands (you may also hear it termed the “HPA Axis”). When HPA is well nourished, other glands of the body benefit as well. When under stress, the adrenal gland takes a big hit, especially if the stress moves from acute (short-lasting stress) to chronic (long-lasting stress). Maca feeds all three glands by supporting the body’s production of hormones, either increasing or decreasing levels according to the need. As a result, maca may help prevent or repair adrenal exhaustion and all of the unhealthy follow-on effects this has on the body and mind. #3. Libido Booster Maca has been used traditionally by Peruvians to boost virility and libido. Science has not yet determined how maca does this, but it has been called “Nature’s Viagra” for good reason. Some health experts believe maca’s effects on libido may be caused by its long-chain fatty acids known as macaenes and macamides, which are unique and have not been found in any other plant. A 2008 clinical study followed women suffering from sexual dysfunction caused by selective serotonin reuptake inhibitors (SSRIs) for depression. The study found that three grams of maca per day gave significant improvement in libido for the women taking it [6]. #4. Cardiovascular Health Maca’s phytosterols – campesteroland beta-sitosterol, act to interfere with the absorption of LDL cholesterol (the so-called “bad” cholesterol), making maca beneficial for the cardiovascular system [7]. Phytosterols have also been studied for their anti-inflammatory effects, which assist in balancing the immune system, and, as an added bonus, help to protect the body from abnormal cell growth. #5. Anti-Cancer A 2015 study found that phytosterols interfere with many different pathways in the carcinogenesis (cancer beginning) process [8]. In addition, an animal study found that beta-sitosterol decreased levels of circulating estrogen and inhibited the growth of estrogen-receptor positive breast cancer tumors [9]. #6. Boosts Immunity The phytosterols in maca stimulate the immune system and increased levels of interleukin-2 and natural killer cells [7] which the body needs to fight abnormal cell growth. #7. Liver Support Being a cruciferous vegetable, maca contains glucosinolates which, when chewed and digested, change into health-promoting chemicals that help protect against cancer. Sulfur-containing glucosinolates form bonds that help the body’s enzymes do their work better. Both sulfur and plant sterols are required in the production of a master antioxidant called glutathione which boosts liver function and helps the liver with detoxification [10]. #8. Healthy Bones Maca’s vitamins and minerals can help to build strong, healthy bones. A 2006 clinical trial found that maca increased bone density markers for the early-postmenopausal women taking it [2]. How to Take Maca Look for organic maca powder grown in Peru. Maca can be added to juices, oatmeal, inside sandwiches, sprinkled on salads, and added to raw food recipes. Just keep in mind that it is best not to heat maca powder to high temperatures which might diminish some of its nutrients. If you use it in recipes, add it after cooking, just before serving. A gentle approach is generally the best way to begin taking maca. Recommendations are to start with a small dose of 1 teaspoon per day. If that is well tolerated, gradually increase the dose to 1 tablespoon, or more. If you haven’t noticed any improvement, remember one trial had women taking 3 grams per day. It can take two or three weeks before you may notice the full benefits of maca. It is also recommended to only take maca daily for a few months and then take a break from it for a month or so before resuming consumption again. Some health experts recommend avoiding maca under the following conditions. Please consult with your own healthcare provider if: you are between the ages of 15 and 35, have a good, mainly plant-based diet, and don’t have mood swings, fluid retention, or any of the symptoms of PMS you have an allergy to iodine you have Hashimoto’s disease or hyperthyroid condition If hormonal fluctuations are creating havoc in your life, consult your natural health practitioner to see if maca might be right for you.     RESOURCES Organixx’s E-Plexx https://shop.organixx.com/collections/all-products/products/e-plexx?gl=5d88ed1102e26b6546380837   16 Signs & Symptoms of Menopause Every Woman Needs to Know (& What to Do About Them!) https://organixx.com/signs-symptoms-menopause/   Healthy Maca Cacao Pie https://organixx.com/maca-cacao-pie-recipe/ [1] Ethnobiology and Ethnopharmacology of Lepidium Meyenii (Maca), a Plant from the Peruvian Highlands [2] Hormone-Balancing Effect of Pre-Gelatinized Organic Maca (Lepidium peruvianum Chacon): (III) Clinical Responses of Early-postmenopausal Women to Maca in Double Blind, Randomized, Placebo-controlled, Crossover Configuration, Outpatient Study [3] Maca Reduces Blood Pressure and Depression, in a Pilot Study in Postmenopausal Women [4] Lepidium Meyenii (Maca) Improved Semen Parameters in Adult Men [5] A Pilot Investigation into the Effect of Maca Supplementation on Physical Activity and Sexual Desire in Sportsmen [6] A Double-blind, Randomized, Pilot Dose-finding Study of Maca Root (L. Meyenii) for the Management of SSRI-induced Sexual Dysfunction [7] Plant Sterols as Anticancer Nutrients: Evidence for Their Role in Breast [8] Beta-Sitosterol: A Promising but Orphan Nutraceutical to Fight Against [9] Beta-Sitosterol, Beta-Sitosterol Glucoside, and a Mixture of Beta-Sitosterol and Beta-Sitosterol Glucoside Modulate the Growth of Estrogen- Responsive Breast Cancer Cells In Vitro and in Ovariectomized Athymic Mice [10] Beta-sitosterol Modulates Antioxidant Enzyme Response in Raw 264.7 Macrophages Subscribe to Empowering You Organically  Never miss an episode!    APPLE PODCASTS                 SPOTIFY                 GOOGLE PODCASTS

What Is Maca? Growing at an elevation of 12-14,000 feet above sea level in the Andes mountains of Peru, maca grows in extreme weather conditions. Thriving in a habitat of intense sunlight, cold temperatures, and strong winds, this tuberous plant is a part of the brassica family. Just like cauliflower, broccoli, and cabbage, maca is a cruciferous vegetable. Nutrients Found in Maca Maca contains plenty of healthy fatty acids, the most abundant being linoleic, oleic, and palmitic acids. Maca contains vitamins A, C, B2, B6, and niacin, as well as minerals – zinc, iron, iodine, copper, calcium, potassium, and magnesium. Nine amino acids are considered essential for optimal health, and maca contains seven of them [1]. Maca is also a rich source of plant sterols, which are part of what makes it so beneficial for hormonal health. Plant sterols are (chemically speaking) structurally similar to the body’s own hormones such as estrogen, progesterone, and testosterone. Maca Is an Adaptogen So how exactly does it work? Maca is an adaptogen, meaning that it works to strengthen, balance, and help the body respond to internal and external changes and stressors. It regulates the production of hormones to maintain healthy organ function. Maca feeds the hypothalamus, pituitary, and adrenal glands, known as the Master Glands (more on that later). Maca’s plant sterols appear to stimulate changes in the action of the hypothalamus, pituitary, and adrenal glands. Maca also seems to exert an influence on the ovaries, pineal gland, and thyroid. How Maca Can Aid Fluctuating Hormones Premenstrual Syndrome (PMS) is one of the most common complaints among women of reproductive age. When out of balance, estrogen – the hormone responsible for regulating the reproductive system – can cause a wide range of symptoms and annoyances for women (and their men!). Mood swings, water retention, fatigue, food cravings, irritability, headaches, irregular menstrual periods, painful cramping… all can be attributable to estrogen imbalance. Maca can help ease the rapid rise and fall of hormones in menstruating women due to its adaptogenic properties. Also, by improving the connection between the brain and the pituitary gland, maca’s ability to help balance levels of circulating hormones is further enhanced. Most PMS sufferers taking maca report a marked improvement in symptoms during their first menstrual period after commencement of maca. Other times when maca may be of benefit to women is after coming off birth control pills, and after having a baby and breastfeeding has ceased. At such times, endocrine system function can be depleted, and maca’s adaptogenic properties mean it can help the body right itself again. Maca can also ease many of the symptoms of perimenopause and menopause. For those harried by hot flashes, night sweats, insomnia, depression, anxiety, and lack of energy, maca can provide some much-needed relief. Maca does not appear to mimic estrogen in the body but it can help to increase the body’s production of estrogen if levels are too low. That’s the beauty of an adaptogenic herb: it adapts to what the body needs. In a 2006 clinical trial, 34 early-postmenopausal women were given a supplement containing either maca or a placebo twice per day for four months. Those receiving the maca had increased levels of estrogen, suppressed levels of FSH, T3 thyroid hormone, adrenocorticotropic hormone, and cortisol (the hormone secreted in response to stress). Body mass index also decreased. Iron levels increased, however, as did bone density markers, and maca relieved many of the symptoms of menopausal discomfort such as hot flashes and night sweats [2]. Another small 2014 clinical study found that maca reduced blood pressure and depression in postmenopausal women [3]. Can Maca Can Also Benefit Men? Maca can also be helpful for male health. Recent studies have indicated that maca may assist male health by helping to increase sperm count and motility, increasing sexual desire, protecting the prostate and reducing the incidence of benign prostatic hyperplasia, reducing stress and depression, boosting energy levels, and easing mild erectile dysfunction [1, 4]. 8 Additional Health Benefits of Maca #1. Boosts Energy and Endurance A 2009 study of male cyclists found that maca supplementation did indeed improve cycling time performance, as well as sexual desire (a perk for many) [5]. #2. Hypothalamus/Pituitary/Adrenal (HPA) Gland Nourishment HPA glands are called the “Master Glands” because they regulate other glands (you may also hear it termed the “HPA Axis”). When HPA is well nourished, other glands of the body benefit as well. When under stress, the adrenal gland takes a big hit, especially if the stress moves from acute (short-lasting stress) to chronic (long-lasting stress). Maca feeds all three glands by supporting the body’s production of hormones, either increasing or decreasing levels according to the need. As a result, maca may help prevent or repair adrenal exhaustion and all of the unhealthy follow-on effects this has on the body and mind. #3. Libido Booster Maca has been used traditionally by Peruvians to boost virility and libido. Science has not yet determined how maca does this, but it has been called “Nature’s Viagra” for good reason. Some health experts believe maca’s effects on libido may be caused by its long-chain fatty acids known as macaenes and macamides, which are unique and have not been found in any other plant. A 2008 clinical study followed women suffering from sexual dysfunction caused by selective serotonin reuptake inhibitors (SSRIs) for depression. The study found that three grams of maca per day gave significant improvement in libido for the women taking it [6]. #4. Cardiovascular Health Maca’s phytosterols – campesteroland beta-sitosterol, act to interfere with the absorption of LDL cholesterol (the so-called “bad” cholesterol), making maca beneficial for the cardiovascular system [7]. Phytosterols have also been studied for their anti-inflammatory effects, which assist in balancing the immune system, and, as an added bonus, help to protect the body from abnormal cell growth. #5. Anti-Cancer A 2015 study found that phytosterols interfere with many different pathways in the carcinogenesis (cancer beginning) process [8]. In addition, an animal study found that beta-sitosterol decreased levels of circulating estrogen and inhibited the growth of estrogen-receptor positive breast cancer tumors [9]. #6. Boosts Immunity The phytosterols in maca stimulate the immune system and increased levels of interleukin-2 and natural killer cells [7] which the body needs to fight abnormal cell growth. #7. Liver Support Being a cruciferous vegetable, maca contains glucosinolates which, when chewed and digested, change into health-promoting chemicals that help protect against cancer. Sulfur-containing glucosinolates form bonds that help the body’s enzymes do their work better. Both sulfur and plant sterols are required in the production of a master antioxidant called glutathione which boosts liver function and helps the liver with detoxification [10]. #8. Healthy Bones Maca’s vitamins and minerals can help to build strong, healthy bones. A 2006 clinical trial found that maca increased bone density markers for the early-postmenopausal women taking it [2]. How to Take Maca Look for organic maca powder grown in Peru. Maca can be added to juices, oatmeal, inside sandwiches, sprinkled on salads, and added to raw food recipes. Just keep in mind that it is best not to heat maca powder to high temperatures which might diminish some of its nutrients. If you use it in recipes, add it after cooking, just before serving. A gentle approach is generally the best way to begin taking maca. Recommendations are to start with a small dose of 1 teaspoon per day. If that is well tolerated, gradually increase the dose to 1 tablespoon, or more. If you haven’t noticed any improvement, remember one trial had women taking 3 grams per day. It can take two or three weeks before you may notice the full benefits of maca. It is also recommended to only take maca daily for a few months and then take a break from it for a month or so before resuming consumption again. Some health experts recommend avoiding maca under the following conditions. Please consult with your own healthcare provider if: you are between the ages of 15 and 35, have a good, mainly plant-based diet, and don’t have mood swings, fluid retention, or any of the symptoms of PMS you have an allergy to iodine you have Hashimoto’s disease or hyperthyroid condition If hormonal fluctuations are creating havoc in your life, consult your natural health practitioner to see if maca might be right for you.     RESOURCES Organixx’s E-Plexx https://shop.organixx.com/collections/all-products/products/e-plexx?gl=5d88ed1102e26b6546380837   16 Signs & Symptoms of Menopause Every Woman Needs to Know (& What to Do About Them!) https://organixx.com/signs-symptoms-menopause/   Healthy Maca Cacao Pie https://organixx.com/maca-cacao-pie-recipe/ [1] Ethnobiology and Ethnopharmacology of Lepidium Meyenii (Maca), a Plant from the Peruvian Highlands [2] Hormone-Balancing Effect of Pre-Gelatinized Organic Maca (Lepidium peruvianum Chacon): (III) Clinical Responses of Early-postmenopausal Women to Maca in Double Blind, Randomized, Placebo-controlled, Crossover Configuration, Outpatient Study [3] Maca Reduces Blood Pressure and Depression, in a Pilot Study in Postmenopausal Women [4] Lepidium Meyenii (Maca) Improved Semen Parameters in Adult Men [5] A Pilot Investigation into the Effect of Maca Supplementation on Physical Activity and Sexual Desire in Sportsmen [6] A Double-blind, Randomized, Pilot Dose-finding Study of Maca Root (L. Meyenii) for the Management of SSRI-induced Sexual Dysfunction [7] Plant Sterols as Anticancer Nutrients: Evidence for Their Role in Breast [8] Beta-Sitosterol: A Promising but Orphan Nutraceutical to Fight Against [9] Beta-Sitosterol, Beta-Sitosterol Glucoside, and a Mixture of Beta-Sitosterol and Beta-Sitosterol Glucoside Modulate the Growth of Estrogen- Responsive Breast Cancer Cells In Vitro and in Ovariectomized Athymic Mice [10] Beta-sitosterol Modulates Antioxidant Enzyme Response in Raw 264.7 Macrophages Subscribe to Empowering You Organically  Never miss an episode!    APPLE PODCASTS                 SPOTIFY                 GOOGLE PODCASTS

In today's episode, Zane interviews Dr. Aaron Wenzel on Hormone Replacement Therapy for Men and Women.  They cover everything you could ever wonder about this topic!  Such as: Is it safe? What are the benefits? Testosterone supplementation for Men Testosterone, Estrogen and Progesterone supplementation for Women Normal Levels vs. Optimal Levels Thyroid supplementation Get all your questions answered in today's episode! You can find out more about Dr. Aaron Wenzel and his practice Brentwood MD at www.brentwoodmd.com   Questions? You can email your questions to zane@zanegriggs.com. Connect with me at zanegriggs.com or on Instagram @zanegriggsfitness   Links to Studies:   Men's studies: EMA Position Statement: www.ema.europa.eu Mayo Clinic Proceedings: www.mayoclinicproceedings.org AACE Annual Meeting Position Statement: www.aace.com Consultant 360: www.consultant360.com NIH Summary Statement Updated 2016: www.ncbi.nlm.nih.gov NIH Test and CV Risks and Mortality 2015: www.ncbi.nlm.nih.gov Science Daily: www.sciencedaily.com   Women's studies:   (EPAT) Estrogen In The Prevention Of Atherosclerosis Trial: www.ncbi.nlm.nih.gov (Cache County Study) HRT and Incidence Of Alzheimer's Disease In Older Women: www.ncbi.nlm.nih.gov Sex, Hormones, and Hysterectomies: www.ncbi.nlm.nih.gov Testosterone Therapy In Postmenopausal Women: www.ncbi.nlm.nih.gov Testosterone Therapy and Carotid Thickness in Pre & Postmenopausal Women: www.ncbi.nlm.nih.gov Testosterone Therapy and Bone Health In Women: www.ncbi.nlm.nih.gov Testosterone Deficiency and Heart Disease Risks in Women: www.ncbi.nlm.nih.gov Testosterone Deficiency and Fatigue / Decreased Well-Being in Women: www.ncbi.nlm.nih.gov Estrogen Therapy and Reduction Of Heart Disease: www.ncbi.nlm.nih.gov Benefits of Estrogen Therapy in Postmenopausal Women: www.ncbi.nlm.nih.gov Estrogen Therapy and Improved Cognition: www.ncbi.nlm.nih.gov Progesterone and Breast Cancer Risks: jamanetwork.com Progesterone Therapy Reduces Depression & Anxiety: www.ncbi.nlm.nih.gov   Quick Episode Summary: Aaron Wenzel introduction Hormone therapy  Safety and Risks Women vs Men and decreasing hormone levels Normal vs. optimal Benefits of testosterone for men Benefits of testosterone for women Understanding the thyroid Sickness Care

Does anastrozole reduce breast cancer risk in postmenopausal women? Find out about this and more in today's PV Roundup podcast.

SHR # 2446 :: BEST OF: Hormonal Contraceptive And Multiple Sclerosis Susceptibility PLUS Effects Of HRT On Cerebral Function In Postmenopausal Women At Risk Of Dementia PLUS Genetic Dysbiosis: The Role Of Microbial Insults In Chronic Inflammation - Guest: Dr. Annette Langer-Gould - Dr. Natalie Rasgon - Dr. Luigi Nibali - This show originally aired in April of 2014. Multiple Sclerosis is on the rise in women. Dr. Langer-Gould's group looked at the linkage between hormonal contraceptives and the prevalence of Multiple Sclerosis. PLUS Dr. Rasgon's group looked at brain function, metabolism and cognition in a group of postmenopausal women who are genetically predisposed to dementia. They compared those who are currently on HRT and those who were on and stopped. They also corrected for those using beta-estradiol, beta-estradiol and progesterone combined and compared to those using Conjugated Equine Estrogen as well as synthetic estrogen and progestins. The results was astounding and explains why the Women's Health Initiative study was a complete failure and ultimately hurt a lot of women. PLUS Many of us are aware of the importance of the microbiome in our body. But what if you can't influence it through the introduction of beneficial microbes? What if your genetics predispose you to specific phyla of microbes and not others. And THIS is the real "genetic predisposition" to developing diseases like Irritable Bowel Syndrome, Rheumatoid Arthritis, Cancer and more. Dr. Nibali's group may have discovered that its your genes that allow your body to adopt some microbes while not others.

SHR # 2446 :: BEST OF: Hormonal Contraceptive And Multiple Sclerosis Susceptibility PLUS Effects Of HRT On Cerebral Function In Postmenopausal Women At Risk Of Dementia PLUS Genetic Dysbiosis: The Role Of Microbial Insults In Chronic Inflammation - Guest: Dr. Annette Langer-Gould - Dr. Natalie Rasgon - Dr. Luigi Nibali - This show originally aired in April of 2014. Multiple Sclerosis is on the rise in women. Dr. Langer-Gould's group looked at the linkage between hormonal contraceptives and the prevalence of Multiple Sclerosis. PLUS Dr. Rasgon's group looked at brain function, metabolism and cognition in a group of postmenopausal women who are genetically predisposed to dementia. They compared those who are currently on HRT and those who were on and stopped. They also corrected for those using beta-estradiol, beta-estradiol and progesterone combined and compared to those using Conjugated Equine Estrogen as well as synthetic estrogen and progestins. The results was astounding and explains why the Women's Health Initiative study was a complete failure and ultimately hurt a lot of women. PLUS Many of us are aware of the importance of the microbiome in our body. But what if you can't influence it through the introduction of beneficial microbes? What if your genetics predispose you to specific phyla of microbes and not others. And THIS is the real "genetic predisposition" to developing diseases like Irritable Bowel Syndrome, Rheumatoid Arthritis, Cancer and more. Dr. Nibali's group may have discovered that its your genes that allow your body to adopt some microbes while not others.

With the onset of menopause, many women may experience a variety of symptoms, including a decrease in lean muscle, an increase in fat mass, and a reduction in cardiorespiratory fitness – which may predispose the menopausal woman to insulin resistance and type 2 diabetes. Research says that one such intervention is aerobic exercise – consisting of 30 to 40 minutes of daily moderate-intensity repeated for three to four weeks over a six month duration.

JAMA (Journal of the American Medical Association) Network Open reported in July 2019 that, “normal-weight central obesity in women was associated with excess risk of mortality, similar to that of women with BMI-defined obesity with central obesity.”

Background: During the reproductive age, the human brain becomes a target for gonadal steroid hormones. Estrogens influence neural function through effects on neurons and affects indirectly the oxidative stress, inflammation, the cerebral vascular and the immune system. Objective: To evaluate the effect of the traditional hormone replacement therapy (HRT) on the cognitive function in postmenopausal women. Materials and Methods: In this randomized clinical trial, 140 postmenopausal women, from November 2014 to February 2015, were included. Women were randomly divided into two groups. Each woman in the case group took traditional HRT (0.625mg conjugated equine estrogens+2.5mg medroxyprogesterone acetate daily) plus one Cal+D tablet (500 mg calcium+200 IU vitamin D) daily for four months. Women in the control group received only one Cal+D tablet (500 mg calcium+200 IU vitamin D) daily for four months period. The Montreal Cognitive Assessment (MoCA) and Green Climacteric Scale (GCS) questionnaires filled out after the intervention and compared between the two groups. Results: The mean points of the MoCA after the intervention indicate that all MoCA domains except for the orientation improved in the case group. There was a significant difference in the memory domain after the treatment between the two groups. MoCA domains and GCS were negatively correlated after the intervention (r=−0.235,p=0.006). Conclusion: The HRT has affected some of the MoCA factors. The effects of HRT on cognitive function should be studied in a large prospective study in a group of women in their early and late menopausal ages with periodic assessment of their cognitive function during these follow-up years. Moradi F, Jahanian Sadatmahalleh S, Ziaei S. The effect of hormone replacement therapy on cognitive function in postmenopausal women: An RCT. Int J Reprod Biomed (Yazd). 2019;16(12):ijrm.v16i12.3682. Published 2019 Jan 28. doi:10.18502/ijrm.v16i12.3682. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Sections of Abstract, Introduction, Materials and Methods, and Discussion are presented in the Podcast. Link to the full-text article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600282/

Credits: 0.25 AMA PRA Category 1 Credits™ Claim CME/CE credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-113-deprescribing Overview: In a recent study of postmenopausal women in the WHI Observational Study who consumed > 2 ASB per day, there appeared to be an association between increased intake of ASB with increased risk of ischemic stroke, CVD, and all cause mortality. Join us as we discuss these findings, what it adds to our knowledge about ASB, and potential strategies to apply this new evidence into your practice.  Guest: Susan Feeney, DNP, FNP  Landing Page: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-120    

Credits: 0.25 AMA PRA Category 1 Credits™ Claim CME/CE credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-113-deprescribing Overview: In a recent study of postmenopausal women in the WHI Observational Study who consumed > 2 ASB per day, there appeared to be an association between increased intake of ASB with increased risk of ischemic stroke, CVD, and all cause mortality. Join us as we discuss these findings, what it adds to our knowledge about ASB, and potential strategies to apply this new evidence into your practice. Guest: Susan Feeney, DNP, FNP  Landing Page: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-120    

Every week, The American Journal of Managed Care® (AJMC®) recaps the top managed care news of the week, and you can now listen to it on our podcast, Managed Care Cast. This week, the top managed care news included CMS' proposal to cover chimeric antigen receptor T-cell therapy; a study faulting the FDA’s handling of fentanyl oversight; and breast surgeons calling for genetic testing for all patients with breast cancer. Read more about the stories in this podcast: CMS Proposes That Patients Be Enrolled in Studies to Get Coverage for CAR T-Cell Therapy: https://www.ajmc.com/newsroom/cms-proposes-that-patients-be-enrolled-in-studies-to-get-coverage-for-car-tcell-therapy Study Criticizes FDA Safety Oversight of Rapid-Release Fentanyl: https://www.ajmc.com/newsroom/study-criticizes-fda-safety-oversight-of-rapidrelease-fentanyl Breast Surgeons Seek Genetic Testing for All Patients With Breast Cancer: https://www.ajmc.com/newsroom/breast-surgeons-seek-genetic-testing-for-all-patients-with-breast-cancer Greater Diet Drink Consumption Heightens Stroke Risk in Postmenopausal Women: https://www.ajmc.com/newsroom/greater-diet-drink-consumption-heightens-stroke-risk-in-postmenopausal-women Advancing Quality Oncology Care in the Evolving Value-Based Care Landscape: https://www.ajmc.com/ivbm-dallas

Interview with Andrew J. Dannenberg, MD, author of Association of Body Fat and Risk of Breast Cancer in Postmenopausal Women With Normal Body Mass Index: A Secondary Analysis of a Randomized Clinical Trial and Observational Study

Interview with Andrew J. Dannenberg, MD, author of Association of Body Fat and Risk of Breast Cancer in Postmenopausal Women With Normal Body Mass Index: A Secondary Analysis of a Randomized Clinical Trial and Observational Study

On this episode of the Healthy Wealthy and Smart Podcast, Tom Goom joins me to discuss a gluteal tendinopathy case study. Tom has gained the nickname ‘Running Physio’ after years of combining his passion for physio and love for running together to specialise in management of running injury. He’s written widely on the topic with over 200 evidence-based articles for his own site, running-physio.com as well as contributing to the BJSM Blog, Runner’s World and the Telegraph. In 2016 he published a masterclass on proximal hamstring tendinopathy in the Journal of Orthopaedic and Sports Physical Therapy. He presents his Running Repairs Course in the UK, internationally and online, covering a range of topics from training load management to bone stress injuries, strength and conditioning and more. In this episode, we discuss: -Crafting the subjective portion of your evaluation -Objective measures at the impairment, activity and participation levels -Multimodal treatment approaches to manage gluteal tendinopathy -Intrinsic factors that affect tendon health -And so much more!   Identifying what running really means to your patient will help guide your goals for therapy as Tom stresses, “I want to know about the impact the injury is having on them.”   Modifying activity levels is an important aspect for your exercise prescription and you have to convey to your patients that, “It’s this kind of balancing act of risk versus reward.”   It is important for clinicians to avoid iatrogenic language in their patient education and only, “Highlight the good things.“   Establish at the onset to, “Expect flair ups.” as managing patient expectations during their rehabilitation is key to long term success.   Treating gluteal tendinopathy is both challenging and rewarding and Tom believes, “There’s an art to it as well as a science.”   For more information on Tom: Tom is a physiotherapist with over 10 years of experience and a very keen runner! He graduated with a BSc (Hons) degree in 2002 and since then has worked in clinics in the UK and overseas. His career started in Winchester where he worked in the NHS and developed a specific interest in lower limb rehab and joined the physio team at a semi-professional football club. Following the Tsunami in 2004 Tom travelled to Sri Lanka and did voluntary physiotherapy work in a hospital, teaching local staff, treating patients and fundraising for new equipment. Tom returned to the UK in 2006 and started working in Brighton as a senior physiotherapist. His interest in rehab continued to grow and he ran lower limb and spinal rehab groups as well a chronic pain programme. Tom started RunningPhysio in March 2012 to help those training for marathons that spring, since then it’s developed into a resource used by runners all over the world. Tom has written for Running Fitness, Men’s Running UK, and the British Journal of Sports Medicine blog. His work has featured on Kinetic Revolution, Bartold Biomechanics and a host of online sports sites.  A few words from Tom… I’m learning about running all the time, one thing I’ve found is that there are a lot of opinions out there! No 2 people will give you the same advice and I respect that. My plan with this site is to share my view on injury prevention and management when running. I welcome different views and ideas so please feel free to comment. I don’t claim to have all the answers but I hope people will find this site helpful. I’ve got a few miles under my belt and a few good PB’s – 39:30 for 10km and a 1:28 half marathon. In April 2013 I did my first marathon and loved it! I finished in 3:12:28 – full story here. I work at The Physio Rooms clinic in Brighton. For more information or to arrange an appointment see our Clinic Page. If you have any questions feel free to leave a comment or chat to me on Twitter via @tomgoom. Please note that due to very high numbers of comments and questions we aren’t able to reply to everyone   Resources discussed on this show: Running Physio Website Running Physio Twitter Running Physio Facebook Tendon Health Questionnaire Pain Catastrophizing Scale Hudl Technique Plinsinga et al 2018: Psychological factors not strength deficits are associated with severity of gluteal tendinopathy: A cross‐sectional study Ganderton et al 2018: Gluteal Loading Versus Sham Exercises to Improve Pain and Dysfunction in Postmenopausal Women with Greater Trochanteric Pain Syndrome: A Randomized Controlled Trial. Mellor et al 2018: Education plus exercise versus corticosteroid injection use versus a wait and see approach on global outcome and pain from gluteal tendinopathy: prospective, single blinded, randomised clinical trial   Thanks for listening and subscribing to the podcast! Make sure to connect with me on twitter, instagram and facebook to stay updated on all of the latest! Show your support for the show by leaving a rating and review on iTunes!   Have a great week and stay Healthy Wealthy and Smart!   Xo Karen    

Authors: Sarah A. Johnson, PhD, RD, CSO; Arturo Figueroa, MD, PhD, FACSM; Negin Navaei, BS; Alexei Wong, MS; Roy Kalfon, BS; Lauren T. Ormsbee, MS; Rafaela G. Feresin, MS; Marcus L. Elam, MS; Shirin Hooshmand, PhD; Mark E. Payton, PhD; and Bahram H. Arjmandi, PhD, RD. Interview: Dr. Arjmandi and Dr. Johnson discuss the results of a new study that found that daily consumption of blueberries for eight weeks resulted in significant reductions of both systolic and diastolic blood pressure. Considering the prevalence of hypertension and cardiovascular disease, preventive strategies such as dietary modifications (e.g. functional foods and dietary supplements) that aim to improve hypertension and its related complications are warranted. (DOI: 10.1016/j.jand.2014.11.001).