Intelligent Medicine

Autism, Functional Medicine, and Personalized Interventions: A Conversation with Theresa Lyons, PhD, a Yale-trained scientist and medical strategist who became an autism expert after her daughter's diagnosis and now runs AWEtism.net. Lyons describes dissatisfaction with conventional guidance that offers limited drugs for irritability and primarily ABA (Applied Behavioral Analysis), which is insurance-covered, often recommended at 40 hours/week, uses extrinsic rewards, and may help some skill-learning but has controversies and limitations for social development; she contrasts newer approaches such as RDI (Relationship Development Intervention) and PRT (Pivotal Response), which aim to build intrinsic motivation but are typically not covered by insurance. The discussion covers autism heterogeneity, changes in diagnostic categories (e.g., Asperger's folded into autism), and research including a Boston Children's Hospital study reporting 37% of children in a cohort lost their autism diagnosis over time (diagnosis based on observation). Lyons addresses debates about rising autism prevalence, noting multiple potential contributors and rejecting single-cause explanations, while citing risk-factor examples such as family autoimmune history and air pollution exposure. She outlines a functional medicine “why” approach using constipation as an example (root causes vs. symptomatic treatment), and emphasizes basic, low-risk steps such as evaluating diet, inflammation, hydration/electrolytes, and blood work for nutrients. Specific topics include gluten-free approaches (mechanisms involving gut permeability, immune burden, and CNS effects), dairy/inflammation, vitamin D deficiency and monitoring, melatonin as a well-studied short-term aid in autism (considered safe for a couple of years in studies) while still seeking underlying causes, and omega-3 fatty acids for focus and inflammation. Lyons explains leucovorin (folinic acid, prescription vitamin B9) as a targeted approach for children with folate receptor antibodies (reported in ~70% of autistic children), discusses the value and cost (~$300) of specialized testing from one U.S. lab, and notes reports of major speech and behavior improvements in responders, with dosing nuances. The episode also reviews evidence and cautions around the microbiome, including fecal microbiota transplant (FDA-approved for C. difficile; discussed as having an ~80% response rate in autism-related studies when gut issues are a key driver, but with major donor/compatibility considerations) and probiotics (some small trials and high costs). Other themes include “clean eating,” organic foods and toxin-load considerations tied to genetic detoxification vulnerabilities, discussion of acetaminophen/Tylenol in pregnancy in the context of glutathione pathways and personalized risk, and using genetics to guide interventions. Lyons warns that analysis of top autism TikTok videos found ~70% were inaccurate or overdramatized, recommending social media only for ideas, not decision-making. She also highlights parent stress, citing emerging research on increased PTSD risk among autism parents, and emphasizes support and community. Lyons advises parents to understand their child's specific health drivers and match them to appropriately specialized clinicians, noting her curated doctor listings in The Lyons Report.

Dr. Hoffman continues his conversation with Theresa Lyons, PhD, a Yale-trained scientist and medical strategist who became an autism expert after her daughter's diagnosis and now runs AWEtism.net.

Xylitol, FTC Censorship, and the Oral–Heart Health Connection: Nathan Jones, CEO and founder of Xlear, Inc., makers of xylitol-based nasal and dental hygiene products, and a health freedom advocate, discusses Jones' ongoing legal battle with the FTC. He addresses the difficulty of making health claims for hygiene products (including toothpaste and nasal sprays), the role of “weasel words” in supplement marketing, and concerns about regulatory double standards versus pharmaceuticals. He also reviews xylitol's benefits for dental caries and respiratory/ear infections, including references to studies and public-health examples (e.g., Finland and a Belize program reducing dental caries costs), and Jones' efforts to encourage Utah to implement xylitol gum programs in schools. He contrasts fluoride's enamel-strengthening approach with xylitol's effect on the underlying bacterial cause of tooth decay, discusses Utah's fluoride policy change and claims about fluoride's limited benefit, and highlights a correlation between poor oral health and cardiovascular risk via inflammation and bacterial translocation into the bloodstream, including pathogens found in atherosclerotic plaque, and links also discussed for dementia and Parkinson's.  They close with commentary on health advocacy in the “MAHA era,” the challenges of entrenched federal bureaucracy, and Jones' preference for advocacy groups that teach industry to push back rather than comply.

Dr. Hoffman continues his conversation with Nathan Jones, CEO and founder of Xlear, Inc.

Vitamin D testing is vital for tailoring doses to optimize health—but regulators are conducting a campaign to deny coverage; Can magnesium be taken simultaneously with blood pressure meds? Lifelong learning delays Alzheimer's onset by 5 years; Your MRI says you have a bum shoulder—but 99% of people show abnormalities even when they have no discomfort; Saunas can help stave off dementia. 

Reflections on the Peter Attia/Epstein scandal; How to lower lp(a)—does diet help? What are bio-active peptides? Could they stave off kidney disease? Scientists just tested the fittest 81-year-old in the world—here's what they found; Media erroneously report that intermittent fasting is not effective for weight loss; Sugary drinks may stoke anxiety in teens; Omega-3s support kids' reading fluency and spelling scores; Surprising study shows saturated fats not harmful to kidneys.

Understanding and Managing Heart Health: In this Heart Health Month episode of the Intelligent Medicine Podcast, nutritionist Leyla Muedin addresses a listener's question about elevated cholesterol levels and calcium scores. Drawing on an article written by Dr. Hoffman, she emphasizes the importance of discussing statin use with a doctor, considering individual risk factors, and getting additional tests like VAPs, NMR, homocysteine, and lipoprotein levels. The episode explores the importance of vitamins K2 and folate in cardiovascular health, addressing nutritional deficiencies, and the impact of dietary choices on heart health.

Highlights from the ANH conference in PhoenixWhat do you think of the supplements I'm taking for borderline osteoporosis?After years of vegetarianism, wouldn't eating meat cause adverse reactions like headaches or nausea?

How big is your butt?I take Famotidine to keep me away from Nexium.  Is this a good strategy?What is your protocol for post-surgical healing?Did I have prostate cancer?What are your thoughts on heart and lung scans as well as full body scans to detect abnormalities?What about scans for diagnosing shoulder pain?Can my husband take bromelain post surgery even if he's taking baby aspirin?

Unveiling the Hidden Dangers of Oxalate Overload with Sally Norton, a Master in Public Health, Ivy League Nutritionist, and author of “Toxic Superfoods: How Oxalate Overload Is Making You Sick and How to Get Better.” The discussion delves into the often misunderstood and overlooked issues related to dietary oxalates, commonly found in plant-based diets. Norton shares her personal health journey, which led to her research on dietary oxalate and its impact on various health conditions beyond kidney stones, including arthritis, fatigue, and neurodegenerative diseases. She explores how common foods like spinach, sweet potatoes, and dark chocolate can contribute to oxalate toxicity, and discusses the potential systemic effects and symptoms such as neurotoxicity and gastrointestinal issues. The conversation also covers the challenges in diagnosing oxalate overload, the inaccuracies in existing oxalate food tables, and practical steps for mitigating its harmful effects through diet and supplementation. Listen in to understand how to balance the benefits of plant-based nutrients with the risks of oxalate overload.

Dr. Hoffman continues his conversation with Sally Norton, a Master in Public Health, Ivy League Nutritionist, and author of “Toxic Superfoods: How Oxalate Overload Is Making You Sick and How to Get Better.” 

Regenerative Agriculture and Natural Dairy with Sam Ingersoll, the marketing director of Kalona SuperNatural, an organic dairy brand sourcing milk from regenerative small family farms. The discussion covers the benefits of regenerative agriculture, the downsides of conventional dairy farming, and the importance of soil health for producing nutrient-dense food. Sam explains the differences between various pasteurization methods, the impact of homogenization, and the significance of A2 versus A1 milk proteins. They also talk about the environmental benefits of rotational grazing and the challenges and opportunities in promoting natural dairy in a market dominated by conventional and plant-based alternatives.

Dr. Hoffman continues his conversation with Sam Ingersoll, the marketing director of Kalona SuperNatural, an organic dairy brand sourcing milk from regenerative small family farms.

Exploring a Novel Nutraceutical Approach to Brain Cancer Treatment: Nutritionist Leyla Muedin discusses a recent study from the Advanced Center for Treatment, Research, and Education in Cancer in Mumbai, India. The study explores the impact of a simple, cost-effective nutraceutical tablet containing resveratrol and copper on glioblastoma, a highly aggressive brain cancer. The results indicate a favorable shift in cancer markers and a reduction in tumor aggression without the side effects associated with conventional treatments like chemotherapy and radiotherapy. This alternative approach suggests a potential paradigm shift in cancer treatment, focusing on healing rather than destroying cancer cells. The episode highlights the significance of thinking outside traditional cancer treatment methods and the promise of nutraceuticals in oncology.

American Heart Association's reaction to the Dietary Guidelines for AmericansMy husband's white blood cell count is low. What can he do to raise it?How much NTFactor lipids powder can I take and for how long?

What doctor or hospital TV shows do you enjoy? Which do you think are most real?Can ChatGPT be trusted for credible information from reliable and verifiable sources?Can GLP-1 drugs help with fatty liver disease?

Optimizing Brain Function at Midlife with cognitive neuroscientist Dr. Therese Huston. She details practical ways to harness brain science for improved functioning, especially for women at midlife. They discuss strategies from Dr. Huston's book, “Sharp: 14 Simple Ways to Improve Your Life with Brain Science,” addressing topics such as exercise, diet, sleep, humor, meditation, and innovative techniques like binaural beats and fixation-focused training. The conversation also emphasizes the unique challenges faced by women aged 40-60 and offers scientifically-backed methods to enhance cognitive performance and manage stress effectively.

Dr. Hoffman continues his conversation with cognitive neuroscientist Dr. Therese Huston, author of “Sharp: 14 Simple Ways to Improve Your Life with Brain Science.” 

Understanding Total Load Theory for Children's Mental Health with Patricia Lemer, author of “Total Load Theory.” The discussion centers around the alarming rise in children's neurodevelopmental and psychological disorders and explores Lemer's comprehensive approach to addressing these issues. Patricia Lemer details her career span from the 1960s focusing on genetic issues in kids to the present, highlighting her involvement with organizations like Children's Health Defense. She explains the 'total load theory,' which posits that a combination of stressors from the environment, diet, and lifestyle contribute to these disorders. Topics include genetics, the impact of mold, vision therapy, and controversial issues like the effects of vaccines. The episode also introduces an AI companion to Lemer's book for personalized health advice.

Dr. Hoffman continues his conversation with Patricia Lemer, author of “Total Load Theory.”

We're all suffering from “cold fatigue”—how cold affects us, and how to alleviate it; “It's all about the bass”—how glute shape influences diabetes risk; “White noise” machines may be undermining your sleep; Weight loss drugs get a boost from menopause hormone therapy; What to do for an osteoporotic vertebral fracture; A summary of my medical bills yields a lesson on medical economics. 

After exercise, does it matter whether you take a protein supplement—or just eat a protein-rich meal? Can melatonin alleviate Irritable Bowel Syndrome? Solutions for Myelodysplastic Syndrome—do you have to stop all supplements? The pros and cons of afternoon naps; Water softening may hike cardio risk; Anthocyanins from foods or supplements can improve impaired glucose tolerance.

The Hidden Dangers of Alternative Sweeteners on Liver Health. Registered dietitian Leyla Muedin weighs in on the rising concerns about metabolic dysfunction associated steato liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD). Leyla discusses the findings of recent research from Washington University at St. Louis, revealing that sugar alcohols like sorbitol, often considered healthier alternatives to refined sugar, may actually be harmful to liver health. She explains how gut bacteria can convert sorbitol into fructose, leading to detrimental effects on the liver. Leyla underscores the prevalence of MASLD in the adult population and its association with obesity and cardiometabolic conditions, emphasizing the need for caution in the consumption of alternative sweeteners.

The case for language learning for older folksCan I still take curcumin while taking a low-dose Crestor? Are there interactions between the two or any other supplements?Which K2 is best?  MK4 or MK7?

The benefits of taking vitamin D with vitamin KWould you recommend Moducare or plant sterols with your allergy protocol?Can taking creatine artificially raise PSA levels?  What are your thoughts on the multidetector CT scan?Are my side effects due to Calocurb or was this just a coincidence?What do you think of FGF-1?  

Unveiling the Yeast Connection: A Conversation on Candida, Allergies, and Advanced Treatments: Dr. Dean Mitchell, a board-certified allergist and immunologist, is the author of “Conquering Candida: The New 30-Day Protocol for Restoring Your Microbiome and Health.” The book updates the longstanding concepts introduced by Dr. Orian Truss and Dr. William Crook. The conversation delves into the symptoms, diagnosis, and treatment of Candida overgrowth, including the role of the microbiome, the misuse of antibiotics, and dietary impacts. Dr. Mitchell also touches upon sublingual immunotherapy for treating food and inhaled allergies, and the emerging understanding of Mast Cell Activation Syndrome (MCAS). The episode is packed with insights from both traditional and integrative medicine, offering listeners a comprehensive view on managing complex immune system issues.

Dr. Hoffman continues his conversation with Dr. Dean Mitchell, a board-certified allergist and immunologist, and the author of “Conquering Candida: The New 30-Day Protocol for Restoring Your Microbiome and Health.”

Uncovering the Power of Magnesium with Dr. Carolyn Dean, MD, ND, a renowned expert in the field. Dr. Dean, author of "The Magnesium Miracle," explains her advocacy for magnesium in both prevention and treatment of various health conditions. She highlights the prevalence of magnesium deficiency, the limitations of current magnesium testing methods, and the necessity of adequate magnesium for overall health. The conversation also explores different forms of magnesium supplementation, the role of other minerals, and innovative ways to ensure adequate magnesium intake. Additionally, Dr. Dean shares insights from her new book, "Exposing Sugar Toxicity: A Clinical Perspective." This episode provides valuable information on how to address magnesium deficiency and its critical role in maintaining good health.

Dr. Hoffman continues his conversation with Dr. Carolyn Dean, author of "The Magnesium Miracle."

Cheeseheads rejoice—New study finds full-fat cheese protective against cognitive decline; New-Think is POLICE, not RICE for injuries (“Motion is the Potion”); U.S. obesity prevalence soars—and new study suggests new GLP-1 drugs aren't the answer; Wild blueberries support heart and brain health; Is a surgical fix necessary for hiatal hernia?

Are seed oils really that bad? Is it preferable to use beef tallow for frying? Are memory supplements effective? EPA begins review of fluoride in drinking water; FDA issues recall over contaminated supplements; A high lp(a) may call for preventive aspirin use; Arthritis breakthrough as scientists discover way of regenerating joint cartilage; Surprising new findings on coffee, tea consumption, and osteoporosis risk; Skipping breakfast, late dinners may boost fracture risk.

Nutritionist Leyla Muedin discusses the importance of maintaining muscle mass during weight loss, highlighting recent research on the benefits of krill oil. Leyla delves into various aspects of the study conducted by Glasgow University's School of Human Nutrition, which demonstrated that daily supplementation with krill oil helps minimize muscle loss despite significant weight loss. The episode covers study details, the impact of krill oil on inflammation, muscle maintenance, and the potential advantages of krill oil over traditional fish oil. Leyla also emphasizes the critical role of a balanced diet and strength training in preserving muscle mass during weight loss journeys.

Fish oil linked to reduced risk of atrial fibrillationIs it safe to take hydrogen peroxide every day over the long term?I've been experiencing arthritis and leg cramps during the night. What should I take?I follow a low-carb diet. Why is my Hemoglobin A1c high?

Anecdote on Heart Rate VariabilityWill there soon be biological criteria for diagnosing clinical depression?What is your opinion on cardioversion for curing atrial fibrillation?What's with the ongoing battle between low fat and full fat dairy advocates?What is the optimal blood level of folate?

Unraveling Migraines with Dr. Elena Gross, an expert on migraines and brain metabolism. She is the founder and CEO of KetoSwiss and MigraKet, is a passionate neuroscientist, has a PhD in clinical research, and is a former chronic migraine sufferer. Dr. Gross discusses her personal journey with chronic migraines and how it led her to develop innovative, natural approaches to migraine relief. She does a deep-dive into the nuances of brain energy, metabolism, oxidative stress, and the role of ketone bodies. Dr. Gross highlights her product line 'Brain Ritual' and how it can support brain health and tackle migraine symptoms. She also touches on the broader implications of these approaches for various neurodegenerative and psychiatric conditions. The discussion aims to offer practical solutions and a holistic understanding of brain health.Click here for $30 off your purchase of Brain Ritual.

Dr. Hoffman continues his conversation with Dr. Elena Gross, an expert on migraines and brain metabolism. She is the founder and CEO of KetoSwiss and MigraKet, is a passionate neuroscientist, has a PhD in clinical research, and is a former chronic migraine sufferer.

Optimizing Skin Health: Gut Microbiome, Probiotics, and Natural Remedies with Dr. Ross Pelton, The Natural Pharmacist and Director of Science & Education for Essential Formulas, which specializes in premium probiotic products. He discusses various methods to enhance skin health, focusing on the role of the gut microbiome, diet, and probiotics. He explores the concept of the gut-skin axis and how intestinal health impacts skin conditions like acne, eczema, and psoriasis. Dr. Pelton highlights specific probiotic products and postbiotic metabolites, explaining their benefits for both gut and skin health. The conversation also touches on lifestyle factors such as hydration, sleep, and exercise, discussing how they contribute to overall skin wellness. Additionally, he delves into the potential anti-aging effects of rapamycin and the importance of maintaining a diverse diet to support a healthy microbiome.

Dr. Hoffman continues his conversation with Dr. Ross Pelton, The Natural Pharmacist and Director of Science & Education for Essential Formulas, which specializes in premium probiotic products.

Press ballyhooed heart, stroke risks associated with Omega-3 supplementation, but new study dispels fears over fish oil-atrial fibrillation link; Research highlights cancer, diabetes risks from food preservatives; Do the new dietary guidelines go too far, or are they a cop-out? GLP-1 weight loss drug use could save airlines millions on fuel costs; Does a “complex tear” of the hip labrum inevitably require surgery?

Can we crack the code on aging, or are humans just “term-limited”? What are some of the most promising anti-aging interventions currently under investigation? We may be curing more cancers, and discovering them earlier, but certain cancers are increasing in incidence, especially among the young; Why extreme old age may be protective against cancer; Big meta-analysis confirms cardio benefits of low-carb diet; Patients with depression who've tried everything obtain surprising relief from vagus nerve stimulation; Blood sugar spikes after meals—even absent diabetes—can drive Alzheimer's risk; New study pushes back on Tylenol-autism link, but highlights poor diet, chemical exposure , pre-natal anti-depressant use as potential culprits.

Nutritionist Leyla Muedin discusses the important relationship between gut health and bone health. Leyla delves into the ways gastrointestinal disorders like Crohn's disease, ulcerative colitis, and irritable bowel syndrome can lead to osteoporosis and increased fracture risks. She explains how chronic inflammation, malabsorption, and dysbiosis are common underlying causes of bone loss. Leyla also reviews scientific studies on the link between the gut microbiome and bone mass, highlighting the potential of fecal microbiome transplants as future treatments for osteoporosis.

"Wintering" - how to optimize your winter experienceWhat we're eating for dinnerAn overview of the Dietary Guidelines for AmericansWhat can I do to rectify any scar tissue in my throat from previous thyroid surgery?What can my son do or take to minimize scarring above his right cheek from a basketball game tussle?

I have neuropathy in both my feet and lower legs.  Are there any natural supplements I can take for it?I purchased two containers of Flavamix. What is the ingredient Lucuma and why is it in their cocoa powder?What are your thoughts on the PSMA PET scan for detecting prostate cancer?What supplements do you recommend for prostate health?What are your thoughts on taking famotidine 2 to 3 times a day for GERD?  Can you discuss the different creatine products?

Exploring the Future of Aging with Journalist William J. Cole, author of “The Big 100: Uncovering the Keys to Longevity." The discussion delves into the challenges and societal implications of increased lifespans, especially among baby boomers. They explore the interplay of genetics and lifestyle in achieving longevity, the role of positivity, and the looming financial and caregiving challenges due to an aging population. Cole emphasizes the importance of adapting society to accommodate this demographic shift and highlights the importance of sustainable and healthy aging practices.

Dr. Hoffman continues his conversation with Journalist William J. Cole, author of “The Big 100: Uncovering the Keys to Longevity."

Embracing a Holistic, Pain-Free Approach to Exercise with Dr. John Rusin, world-renowned strength coach, physical therapist, and injury prevention expert. He's author of "Pain-Free Performance: Move Better, Train Smarter, and Build an Unbreakable Body." John is the founder of the Pain-Free Performance Specialist Certification (PPSC), which has certified over 20,000 fitness and rehab professionals worldwide. He discusses the importance of a comprehensive approach to fitness, focusing on diet, sleep, mood, attitude, supplements, and, importantly, exercise. He emphasizes sustainable, pain-free strength training suitable for all ages and fitness levels. The conversation challenges the outdated 'no pain, no gain' philosophy and highlights the significance of balanced fitness, encompassing strength training, cardio, mobility, and athleticism for overall health and longevity. Practical advice on avoiding overtraining, incorporating HIIT intelligently, and the critical role of protein and creatine supplementation is provided. The episode encourages listeners to take actionable steps towards a lifelong commitment to fitness, emphasizing that the right movement practice can enhance both physical health and mental well-being.

Dr. Hoffman continues his conversation with Dr. John Rusin, world-renowned strength coach, physical therapist, and injury prevention expert. He's author of "Pain-Free Performance: Move Better, Train Smarter, and Build an Unbreakable Body."

Oprah's new book encourages followers to “free themselves” from “shame and blame” by accessing weight loss meds; Her claim “it's the obesity gene” is put to the test by twin studies; Study shows brain stimulation with external electronic headset produces weight loss rivaling shots, pills; Ultra-processed food ups daily calorie intake by 500; Breast-feeding moms gain less post-pregnancy weight; Solutions for  Myelodysplastic Syndrome; Scientists find hidden weight gain trigger in soybean oil.

Calculators that assess your risk for heart disease miss the boat—half of actual heart attack victims were said to be at low-risk; Why an app could erroneously tell you that you should be taking a statin; New ways to fix a calcified aortic valve; Common amino acid may bust Alzheimer's plaque, Adequate sleep may trump healthy diet, exercise for longevity; Chinese vegetarians less likely than omnivores to surpass 100; Easily-gobbled “fast food” stokes total daily calorie intake; Common chemicals hike MS risk two-fold; Low-glutamate diet relieves migraines; Fish oil confers substantial stroke, heart attack protection to dialysis patients.

Challenges of GLP-1 Drugs and New Dietary Guidelines for Americans. Nutritionist Leyla Muedin discusses the recent findings on weight regain after stopping GLP-1 receptor agonists like OZEMPIC and Wegovy, based on a recent British Medical Journal editorial. The episode also highlights the Dietary Guidelines for Americans (2025-2030), which recommend focusing on real, nutrient-dense foods, prioritizing protein, and reducing highly processed foods. Leyla addresses the importance of maintaining healthy eating habits during and after using GLP-1 drugs to achieve long-term weight management and overall health.

A spoof on suggested nutrition guidelinesDoes nicotine destroy the spine?  I can't seem to find Alpha Base with or without iron anymore. What do you recommend?