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From building a data platform and Parquet at Twitter to using AI to make biology easier to engineer at Ginkgo Bioworks, Dmitriy joins the show to chat about the early days of big data, the conversation that made him jump into SynBio, LLMs for proteins and more. Segments: (00:03:18) Data engineering roots (00:05:40) Early influences at Lawrence Berkeley Lab (00:09:46) Value of a "gentleman's education in computer science" (00:14:34) The end of junior software engineers (00:20:10) Deciding to go back to school (00:21:36) Early experiments with distributed systems (00:23:33) The early days of big data (00:29:16) "The thing we used to call big data is now ai" (00:31:02) The maturation of data engineering (00:35:05) From consumer tech to biotech (00:37:42) "The 21st century is the century of biology" (00:40:54) The science of lab automation (00:47:22) Software development in biotech vs. consumer tech (00:50:34) Swes make more $$ than scientists? (00:54:27) Llms for language is boring. Llms for proteins? that's cool (01:02:52) Protein engineering 101 (01:06:01) Model explainability in biology Show Notes: The Death of the Junior Developer: https://sourcegraph.com/blog/the-death-of-the-junior-developer Dmitriy on twitter: https://x.com/squarecog?lang=en Tech and Bio slack community: https://www.bitsinbio.org/ Stay in touch: - Make Ronak's day by signing up for our newsletter to get our favorites parts of the convo straight to your inbox every week :D https://softwaremisadventures.com/ Music: Vlad Gluschenko — Forest License: Creative Commons Attribution 3.0 Unported: https://creativecommons.org/licenses/by/3.0/deed.en
Join us on an empowering journey with Dr. Jennifer Holmgren, CEO of LanzaTech, and Aura Cuellar, President of LanzaTech, as they share their remarkable paths from the realms of oil and gas to revolutionizing the clean tech sector. In this episode, we explore the deep convictions and strategic prowess that empowered these two Colombian women to lead monumental projects, pushing the boundaries of what many deemed impossible. Both stories converge in their leadership at LanzaTech, symbolizing a transformative blueprint for the future of energy.
David Younger and Randolph Lopez, co-founders of A-Alpha Bio, on using synthetic biology and AI to discover new biologic drugs.
It's 5:00AM in Toluca when Sofia Sanchez wakes up to the sound of her Westclox, ready for another day as a business major. She drives to her hometown's business school, listening to the radio, wondering what her professor's reaction will be to the 76-page final report she wrote with the help of her beloved IBM Selectric, her worn-out Chartpak stencil, her family's encyclopedia, and Mexico City's IBM center for some calculations. She makes a stop at a phone call station to remind her teammate to correct the finger mistake on the cardboard they made about some ultra-innovative “personal computing” devices her uncle in the US once told her about. Not much more is to be said about Sofia Sanchez. April 1st, 2024 was just another day for a normal 20-year-old in a small town in Mexico.Thank Lick it's April Fool's!“How do the current and next thing get determined?” was the question that gave birth to this piece. Whether they'd be ideas, beliefs, fonts, or technologies, I'd been deeply curious to understand the nature of trends in our world. I wanted to know if there were principles for steering the world towards a particular direction, and whether I could use those principles to change the way biotechnology changes the world.For the past few weeks, I've explored J.C.R Licklider's visionary mind, Everett Roger's theory on the Diffusion of Innovations, René Girard's Theory of Mimetic Desire, and the desires of GenZ influencers on Instagram. This piece is a third batch of thoughts at the intersection of culture and biology, this time focusing on how biology can influence modern culture as much as modern culture influences biology.The Presynbiotech EraThe habitants of the terrifying alternate universe I described in the very first paragraph, are firm believers that the future is merely what hasn't happened yet but eventually will. To them, technology equals destiny and evolution is synonymous with inexorable. What we, in this universe made happen in 30 years, they might start dreaming about in 60.To yours and my own fortune, 5 years prior to the birth of Moore's Law, Man-computer symbiosis was published by J.C.R Licklider (Lick for us friends). While Moore had made an accurate prediction on how far we could take computers, Lick set a clear vision and agenda for how personal computers and the intergalactic network would become the new medium of creative expression: how tech would change culture.Lick dreamed about everything from Zoom to PayPal, Instagram, and the iPad and he led the development of early versions of them. Slightly paraphrased, one of my absolute favorite passages in the Dream Machine book answers how he did that:Lick knew he couldn't get it all done in one year or two years or a lifetime. By creating a community of fellow believers, however, he guaranteed that his vision would live on after him. When he arrived at ARPA in 1962, there was nothing more than a handful of uncoordinated efforts scattered across the country. By the time he left in 1964, he had forged those into a nationwide movement with direction, coherence and purpose. By putting most of the money into universities, he supported the rising generation, whose hearts and minds he won and convinced that computer science was an exciting thing to do. In 1988, that community was the one thing that he was willing to take credit for: “I think I found a lot of bright people and got them working in this area”.Of course, we would be doomed too if the world was only full of dreamers like Lick! We need builders like Alan Kay who build them to life and artists like Steve Jobs who steal from them and bring the tech to everyone once it's cheap enough. Call it lack of vision, bad management or timing, neither Intel nor H&P nor Xerox nor IBM capitalized on their decades of technological advantage over the garage hackers. Yet the garage hackers didn't invent the tech alone; they more so put the puzzle together once the pieces were there. Dream, build, sell.Today, we are living in the Presynbiotech Era. It is a time before ubiquitous Artificial Intelligence-engineered life, a time before the worlds of silicon and carbon intelligence truly fuse as one.Oddly enough, I have not yet encountered a clear 50-year dream of the social paradigm shifts that we will create through biotechnology. If no one's even dreaming, how will we arrive at a different future❗❓Computers have changed the way we think. Synbio will change the way we feel. There will not only be dinosaurs, but UBERs, TikTok marketplaces and AirBnBs. We will have new kinds of enhanced humans of mixed sexes, races and talents, iPlants that act as programmable vending machines where I can buy anything from on the street, an axolotl-turtle hybrid that wakes me up in the morning and cleans my bedroom, and expresso machines that use personalized capsules that keep track of and maintain each one of my biomarkers in place. End of famine, disease, poverty and war too.The fact that we even start thinking of a Pre-synbiotech Era means that we can start dreaming about a Synbiotech one. If you'd been waiting for a call, here you go: I'm calling YOU to share more audacious, truly crazy, dreams of a Synbiotech future, for those who look back on these dreams 50 years hence might as well be living them.And surely, remember: had the world waited for Lick to sell iPads, you would not be reading this either. Dreams matter as much as execution and you truly can learn anything. So if you enjoy building, go for it. Real artists ship.Today's weirdos are tomorrow's basicsIn his Theory on the Diffusion of Innovations, Everett Rogers defines innovation as anything that is perceived as new by someone. He categorizes the adopters of an innovation into 5 main groups, according to influential power, risk aversion and the resulting order in which they adopt: the innovators, early adopters, early majority, late majority, and laggards—A business school all-time favorite.The graph is so good that reading the whole book won't get you much farther than: 1) it's early adopters (aka influencers) and not innovators who bring innovations to billions; 2) though anyone can be an influencer, the closer the better; 3) the who matters more than the what.The theory checks as I go back to my latest purchasing and habit decisions. For example, I'd heard about the WHOOP band from Bryan Johnson, Steve from Diary of a CEO, other macro influencers and numerous YouTube ads, but I was only convinced enough to buy it until I interacted closely with a user I could relate to: a young, female, Mexican bioengineer who'd graduated from the same university where I study.Something that Tesla has left clear too, is that innovators and early adopters can absorb the cost of being first. They are not only helping spread the technology by providing feedback and generating revenue but by modeling that desire to the early majority that relies on and admires them.Where Rogers falls short and Girard goes deeper is in the actual dynamics between influencers and followers. What I learned from reading about the Theory of Mimetic Desire is that, in our quest for personal differentiation, we look up to people whom we can relate to, who are looked up to by people like us AND who have something we still lack.The most obvious examples of influencers are early adopters like Bryan Johnson and Steve. The more subtle yet more powerful influencers are people like the bioengineer with the WHOOP who had something I wanted (being perceived as a healthy person) while still being relatable.Lick's dreams have come to life to such an extent that being an internet influencer is no longer exclusive to elites. The rise of the microinfluencer (
It's 5:00AM in Toluca when Sofia Sanchez wakes up to the sound of her Westclox, ready for another day as a business major. She drives to her hometown's business school, listening to the radio, wondering what her professor's reaction will be to the 76-page final report she wrote with the help of her beloved IBM Selectric, her worn-out Chartpak stencil, her family's encyclopedia, and Mexico City's IBM center for some calculations. She makes a stop at a phone call station to remind her teammate to correct the finger mistake on the cardboard they made about some ultra-innovative “personal computing” devices her uncle in the US once told her about. Not much more is to be said about Sofia Sanchez. April 1st, 2024 was just another day for a normal 20-year-old in a small town in Mexico.Thank Lick it's April Fool's!“How do the current and next thing get determined?” was the question that gave birth to this piece. Whether they'd be ideas, beliefs, fonts, or technologies, I'd been deeply curious to understand the nature of trends in our world. I wanted to know if there were principles for steering the world towards a particular direction, and whether I could use those principles to change the way biotechnology changes the world.For the past few weeks, I've explored J.C.R Licklider's visionary mind, Everett Roger's theory on the Diffusion of Innovations, René Girard's Theory of Mimetic Desire, and the desires of GenZ influencers on Instagram. This piece is a third batch of thoughts at the intersection of culture and biology, this time focusing on how biology can influence modern culture as much as modern culture influences biology.The Presynbiotech EraThe habitants of the terrifying alternate universe I described in the very first paragraph, are firm believers that the future is merely what hasn't happened yet but eventually will. To them, technology equals destiny and evolution is synonymous with inexorable. What we, in this universe made happen in 30 years, they might start dreaming about in 60.To yours and my own fortune, 5 years prior to the birth of Moore's Law, Man-computer symbiosis was published by J.C.R Licklider (Lick for us friends). While Moore had made an accurate prediction on how far we could take computers, Lick set a clear vision and agenda for how personal computers and the intergalactic network would become the new medium of creative expression: how tech would change culture.Lick dreamed about everything from Zoom to PayPal, Instagram, and the iPad and he led the development of early versions of them. Slightly paraphrased, one of my absolute favorite passages in the Dream Machine book answers how he did that:Lick knew he couldn't get it all done in one year or two years or a lifetime. By creating a community of fellow believers, however, he guaranteed that his vision would live on after him. When he arrived at ARPA in 1962, there was nothing more than a handful of uncoordinated efforts scattered across the country. By the time he left in 1964, he had forged those into a nationwide movement with direction, coherence and purpose. By putting most of the money into universities, he supported the rising generation, whose hearts and minds he won and convinced that computer science was an exciting thing to do. In 1988, that community was the one thing that he was willing to take credit for: “I think I found a lot of bright people and got them working in this area”.Of course, we would be doomed too if the world was only full of dreamers like Lick! We need builders like Alan Kay who build them to life and artists like Steve Jobs who steal from them and bring the tech to everyone once it's cheap enough. Call it lack of vision, bad management or timing, neither Intel nor H&P nor Xerox nor IBM capitalized on their decades of technological advantage over the garage hackers. Yet the garage hackers didn't invent the tech alone; they more so put the puzzle together once the pieces were there. Dream, build, sell.Today, we are living in the Presynbiotech Era. It is a time before ubiquitous Artificial Intelligence-engineered life, a time before the worlds of silicon and carbon intelligence truly fuse as one.Oddly enough, I have not yet encountered a clear 50-year dream of the social paradigm shifts that we will create through biotechnology. If no one's even dreaming, how will we arrive at a different future❗❓Computers have changed the way we think. Synbio will change the way we feel. There will not only be dinosaurs, but UBERs, TikTok marketplaces and AirBnBs. We will have new kinds of enhanced humans of mixed sexes, races and talents, iPlants that act as programmable vending machines where I can buy anything from on the street, an axolotl-turtle hybrid that wakes me up in the morning and cleans my bedroom, and expresso machines that use personalized capsules that keep track of and maintain each one of my biomarkers in place. End of famine, disease, poverty and war too.The fact that we even start thinking of a Pre-synbiotech Era means that we can start dreaming about a Synbiotech one. If you'd been waiting for a call, here you go: I'm calling YOU to share more audacious, truly crazy, dreams of a Synbiotech future, for those who look back on these dreams 50 years hence might as well be living them.And surely, remember: had the world waited for Lick to sell iPads, you would not be reading this either. Dreams matter as much as execution and you truly can learn anything. So if you enjoy building, go for it. Real artists ship.Today's weirdos are tomorrow's basicsIn his Theory on the Diffusion of Innovations, Everett Rogers defines innovation as anything that is perceived as new by someone. He categorizes the adopters of an innovation into 5 main groups, according to influential power, risk aversion and the resulting order in which they adopt: the innovators, early adopters, early majority, late majority, and laggards—A business school all-time favorite.The graph is so good that reading the whole book won't get you much farther than: 1) it's early adopters (aka influencers) and not innovators who bring innovations to billions; 2) though anyone can be an influencer, the closer the better; 3) the who matters more than the what.The theory checks as I go back to my latest purchasing and habit decisions. For example, I'd heard about the WHOOP band from Bryan Johnson, Steve from Diary of a CEO, other macro influencers and numerous YouTube ads, but I was only convinced enough to buy it until I interacted closely with a user I could relate to: a young, female, Mexican bioengineer who'd graduated from the same university where I study.Something that Tesla has left clear too, is that innovators and early adopters can absorb the cost of being first. They are not only helping spread the technology by providing feedback and generating revenue but by modeling that desire to the early majority that relies on and admires them.Where Rogers falls short and Girard goes deeper is in the actual dynamics between influencers and followers. What I learned from reading about the Theory of Mimetic Desire is that, in our quest for personal differentiation, we look up to people whom we can relate to, who are looked up to by people like us AND who have something we still lack.The most obvious examples of influencers are early adopters like Bryan Johnson and Steve. The more subtle yet more powerful influencers are people like the bioengineer with the WHOOP who had something I wanted (being perceived as a healthy person) while still being relatable.Lick's dreams have come to life to such an extent that being an internet influencer is no longer exclusive to elites. The rise of the microinfluencer (
Episode Description: Dr. Tara Shirvani shares her rich knowledge about the transformative power of synthetic biology across various sectors, far beyond its roots in pharmaceuticals. With a passionate discussion ranging from the potential of algae biofuels to the innovative approaches towards addressing the climate crisis, Tara paints a vivid picture of a future where synthetic biology plays a crucial role in creating sustainable solutions for some of our planet's most pressing challenges. She delves into the critical importance of financing and policy support in scaling biotech innovations and underscores the untapped potential lying in the intersection of biology and technology to reinvent industries, combat climate change, and pave the way for a more sustainable world. This episode is a must-listen for anyone interested in the cutting-edge intersections of biotechnology, climate action, and the evolving landscape of global economies, offering a compelling overview that builds curiosity and interest in the boundless possibilities that synthetic biology holds. Grow Everything brings the bioeconomy to life. Hosts Karl Schmieder and Erum Azeez Khan share stories and interview the leaders and influencers changing the world by growing everything. Biology is the oldest technology. And it can be engineered. What are we growing? Learn more at www.messaginglab.com/groweverything Chapters: 00:00:00 - Life and Events in the Bustling Heart of New York 00:00:56 - Diving into the Vibrant Biotech Event Landscape 00:02:10 - New York Bio's Pivotal Role in Shaping Life Sciences 00:04:24 - Biotech's Transformative Influence on New York 00:08:18 - Envisioning Synthetic Biology Through the Lens of Disney Magic 00:09:18 - How Synthetic Biology is Reimagining Media's Future 00:12:32 - Bridging Biotech with Climate Technology 00:14:05 - A Deep Dive with Dr. Tara Shirvani on Synthetic Biology's Potential 00:31:07 - Exploring Investment and Regulations Across Europe 00:33:38 - Deciphering Challenges in Biotech Investment and Growth 00:35:28 - Anticipating the Shift in Carbon Pricing and Bio-materials 00:38:18 - Debating the ESG Controversy and Its Impact 00:41:39 - Synthetic Biology's Key Role in Climate Action Strategies 00:47:12 - Evaluating the Economic Impact of Synthetic Biology 00:50:56 - Highlighting Synthetic Biology's Role in Environmental Remediation 00:52:58 - The Crucial Role of Policy in Advancing Synthetic Biology 00:57:40 - The New Frontier: Synthetic Biology in Mining and Remediation Episode Links: Tara Shirvani LinkedIn (link) Plastic Eaters and Turbo Trees by Tara Shirvani (link ) Spin Ping Pong bar (link) KarlSchmieder.com (link) J&J JLabs link NewYorkBio link Biotech.xyz link BioEU link JP Morgan conference link CleanTech Open link Newlab link Brooklyn Navy Yard link COP28 link Carbios link Allonia link Nicole Richards interview (episode link) Get $300 off Synbiobeta tickets (May 6-9 in San Jose, CA) using promo code: Grow Everything Topics Covered: biomaterials, sustainability, biodegradablility, compostibility Have a question or comment? Message us here: Text or Call (804) 505-5553 Instagram / TikTok / Twitter / LinkedIn / Youtube / GrowEverything website Email: groweverything@messaginglab.com Support here: Patreon Music by: Nihilore Production by: Amplafy Media --- Send in a voice message: https://podcasters.spotify.com/pod/show/messaginglab/message
Synthetic biologist Kole Roybal joins us today. Kole is a leader in the emerging area of cell therapy, and has developed sophisticated ways of controlling immune cells for the treatment of cancer. He explains what led to these very recent breakthroughs and what he's excited about next.
Episode Description: How can biotechnology transform the world and beyond? That's the question that John Cumbers, a biotech visionary and entrepreneur, explores in this episode of the podcast. He reveals how biotechnology is merging with other sectors, such as space exploration, and how synthetic biology is reshaping the future. He also discusses how biotech can help solve global problems, from environmental to health issues. He shares his insights on the latest trends and innovations in biotech, such as AI and decentralized science, and how they are creating new possibilities and challenges. He also tells his story, from working at NASA to founding SynBioBeta, and how he envisions a future where biology and technology create amazing solutions for humanity. Grow Everything brings the bioeconomy to life. Hosts Karl Schmieder and Erum Azeez Khan share stories and interview the leaders and influencers changing the world by growing everything. Biology is the oldest technology. And it can be engineered. What are we growing? Learn more at www.messaginglab.com/groweverything Topics Covered: 00:00:00 - Exploring Global Biotech Innovations: Focus on Saudi Arabia 00:01:57 - Overcoming Hurdles in Global Biotech Projects 00:03:35 - Visioning the Future: Sustainable Biotech Solutions Worldwide 00:04:17 - Spotlight on Africa: Biotech's Role in Sustainable Development 00:05:24 - Strategic Moves: Shaping the Future of Biotech Startups 00:07:38 - Exclusive: John Cumbers on Pioneering Biotech Advancements 00:18:52 - Decentralizing Science: The Rise of DAOs in Biotech 00:22:44 - Beyond Earth: The Nexus of Space Exploration and Biology 00:29:44 - A Glimpse into the Future: AI Meets Synthetic Biology 00:34:03 - Rethinking Synthetic Biology: A Lively Debate 00:37:26 - Safeguarding the Future: Biotech in National Security 00:40:05 - Competing on a Global Stage: Insights into Biotech Ecosystems 00:47:25 - Launching New Ventures: The Evolution of Biological Enlightenment Studios 00:50:15 - Wrapping Up: Key Takeaways from Our Discussion with John Cumbers Episode Links: Get $300 off Synbiobeta tickets (May 6-9 in San Jose, CA) using promo code: Grow Everything Saudi Arabia National Biotech Strategy (news) Masdar City in Abu Dhabi (website) The Line by NEOM in Saudia Arabia (website) Synbiobeta Investor Report 2024 (website) BetaSpace on the Moon 2030 (website) Neoplants (website) Biofabricate (website) Light Bio (website) Molecule DAO (website) Valley DAO (website) Athena DAO (website) Hair DAO (website) Vita DAO (website) Paul Stamets (wikipedia) Martine Rothblatt (wikipedia) Craig Venter (wikipedia) Sang Yup Lee (website) Drew Barry Central Dogma (video) National Security Commission on Emerging Biotechnology (website) Ailurus (website) Lantern Bio oral microbiome company (website) Synthetic Biology by Vantage Films (video) Polybion x Ganni (story) Have a question or comment? Message us here: Text or Call (804) 505-5553 Instagram / TikTok / Twitter / LinkedIn / Youtube / GrowEverything website Email: groweverything@messaginglab.com Support here: Patreon Music by: Nihilore Production by: Amplafy Media --- Send in a voice message: https://podcasters.spotify.com/pod/show/messaginglab/message
Innovative companies are using synthetic biology to engineer organisms and create new materials that could transform every sector of our economy, from health care to food and energy production. Those companies say we've entered a synbio revolution, and it holds potential to improve the health of people and our planet. In this episode, we talk with three synbio experts about how this convergence of genetic engineering, computer science and other scientific disciplines is making our world more sustainable. Follow us on LinkedIn, X, Facebook and Instagram. Visit us at https://www.bio.org/
When Aether Bio raised USD 49 mio in a Series A a few months ago, it provided much-needed good news across the synbio sector. I was so curious about the technology and the differentials between companies like Gingko. I wanted to understand how they built a novel material that could theoretically improve lithium production in the US by 30 times. Thanks so much to Pavle Jeremić, CEO and Founder of Aether Bio, for coming onto this week's Leaders on a Mission podcast and sharing his incredibly vibrant and passionate journey. We covered so much ground, including how he created Aether's revolutionary nanoscale platform to deliver cheaper, faster, and greener solutions than any current technology or process on the market. The challenges of fundraising in the current environment, how he was weeks away from running out of cash, and his vision in helping Synbio address scarcity challenges by engineering enzymes to create novel products for a sustainable future
Follow us on LinkedIn, X, Facebook and Instagram. Visit us at https://www.bio.org/Innovative companies are using synthetic biology to engineer organisms and create new materials that could transform every sector of our economy, from health care to food and energy production. Those companies say we've entered a synbio revolution, and it holds potential to improve the health of people and our planet. In this episode, we talk with three synbio experts about how this convergence of genetic engineering, computer science and other scientific disciplines is making our world more sustainable.
Space's unique environment holds vast potential for biotech advancements, Mark Kugel, co-CEO and cofounder of German space biotech company Yuri, told Payload. Why space? In this week's Pathfinder podcast, Mark says that space changes biological systems in commercially valuable ways:– Complex Cell Development: Enhanced growth results in superior organoids, optimizing drug testing and tissue engineering.– Crystal Quality and Size: Space improves the formation of protein crystals, bolstering drug discovery and delivery processes.– Human Aging Effects: Studying space's impact on aging could illuminate early-stage drug solutions for age-driven diseases, such as cancer.– Microbial Evolution: Space prompts unique microbial adaptations, potentially producing advanced strains and enzymes beneficial for the pharma, food, and agritech sectors. Yuri's core innovations:– Space-ready Bioreactors: Yuri's modular bioreactor system offers a novel approach for cultivating biological materials in space. Compact and transport-friendly, it's tailored for expeditions, including the ISS.– Ground-Based Space Simulation: Prior to committing to space-bound projects, researchers can utilize Yuri's simulator to anticipate the effects of microgravity on their experiments. Yuri's partners range from pharmaceutical giants and government agencies to academic institutions. The company has worked with the likes of NASA, ESA, and GSK, the British multinational pharma and biotech company. A sneak peek…Before Yuri, Mark Kugel supported the digital transformation of Rolls-Royce Power Systems and built an "Airbnb for consumer products" called Usely. In today's episode, we chat:– Yuri's origin story– A history of biotech in space– The initial focus on synbio and drug discovery– Why space biotech is ready for commercialization This episode is brought to you by SpiderOak, a US-based software company that builds space cybersecurity products and solutions for civilian, military, and commercial space operations. Learn more at https://spideroak.com/And much more… • Chapters •00:00 - Intro & SpiderOak Ad01:42 - What does Yuri do?02:35 - How did Mark get into bio tech and start working at Yuri?06:06 - Is this industry starting to inflect?09:31 - What does microgravity enable in biotech?15:51 - Bacteria in space18:37 - Space biotech industry now vs. the future24:23 - Yuri's business model32:00 - Yuri's team35:05 - Synbio from the context of space38:59 - From R&D in space to Earth at scale41:20 - Milestones at Yuri42:44 - Yuri's competitors44:07 - Why is Germany the right place to build?46:03 - Government use case47:10 - Yuri in 10-20 years48:33 - Space tech that Mark is excited about49:26 - When is Yuri's next project launching? • Show notes •Yuri's website — https://yurigravity.com/Yuri' socials — https://twitter.com/yurigravityMo's socials — https://twitter.com/itsmoislamPayload's socials — https://twitter.com/payloadspace / https://www.linkedin.com/company/payloadspacePathfinder archive — Watch: https://www.youtube.com/@payloadspace Pathfinder archive — Listen: https://pod.payloadspace.com/episodes • About us •Pathfinder is brought to you by Payload, a modern space media brand built from the ground up for a new age of space exploration and commercialization. We deliver need-to-know news and insights daily to 15,000+ commercial, civil, and military space leaders. Payload is read by decision-makers at every leading new space company, along with c-suite leaders at all of the aerospace & defense primes. We're also read on Capitol Hill, in the Pentagon, and at space agencies around the world. Payload began as a weekly email sent to a few friends and coworkers.Today, we're a team distributed across four time zones and two continents, publishing three media properties across multiple platforms: 1) Payload, our flagship daily newsletter, sends M-F @ 9am Eastern (https://newsletter.payloadspace.com/) 2) Pathfinder publishes weekly on Tuesday mornings (pod.payloadspace.com) 3) Polaris, our weekly policy publication, hits inboxes Tuesday (https://polaris.payloadspace.com/) 4) Parallax, our weekly space science briefing, hits inboxes Thursday (https://parallax.payloadspace.com/)
For all the exciting developments in the synthetic biology industry, there are also concerns. People can edit genes in their garages these days, so who's regulating this space? Plus - we'll hear about the exciting new business models with biology at their core, including one of the first synbio businesses to trade as a public stock - Ginkgo Bioworks. Presenter: Gareth Mitchell Producer: Izzy Greenfield (Image: A petri dish in a lab. Credit: Getty Images)
In this week's series focusing on business and science, we start things off by looking at the world of synthetic biology. The industry is estimated to be worth around $30bn in the next few years, but how is that money actually made? We speak to businesses across the world to find out how they've taken the building blocks of synthetic biology and engineered them into products that we use on a daily basis. Presenter: Gareth Mitchell Producer: Izzy Greenfield (Image: A scientist working with lab grown meat. Credit: Getty Images)
Episode Description: Karl and Erum sit down with Ben Novak to delve deep into the world of biotechnology and its potential to Revive and Restore extinct species. From the dramatic decline of the passenger pigeon to the innovative efforts of conservation through biotechnology, the conversation touches on the challenges and promises of using science to rejuvenate our planet's biodiversity. The trio also discusses the broader implications of biotech in areas like food and cultivation, offering listeners a comprehensive look at the intersection of science, ethics, and entrepreneurship. Grow Everything brings to life the bioeconomy when hosts Karl Schmieder and Erum Azeez Khan share stories from the field and interview leaders and influencers in the space. Life is a powerful force and it can be engineered. What are we creating? Learn more at www.messaginglab.com/groweverything Topics Covered: 00:00:00: Kick-off: Karl, Erum, and Ben's Personal Journeys 00:07:31: Unmasking Opioids: The Dark Reality Behind "Pain Killers" 00:11:02: Business Lessons: The Rise and Demise of Amri 00:15:47: Nature's Revival: The Science of Bringing Back Extinct Species 00:21:45: Biotech's Promise: Reimagining the Return of Extinct Species 00:25:36: Birds of Yore: The Enigmatic Tale of Passenger Pigeons 00:33:26: Ecosystem Architects: How Passenger Pigeons Shaped Forests 00:37:14: Green Solutions: Passenger Pigeons and Sustainable Forestry 00:42:50: Collaborative Conservation: Genomic Solutions and Funding Avenues 00:48:11: Banking on Biodiversity: The Need for Biosample Preservation 00:56:00: Past Meets Present: Exploring Animal Behavior in Conservation 01:03:53: Deep Dive: Ben Novak on the Mission to Revive and Restore 01:08:10: Future of Biodiversity: The Push for Informed Bio Banking Episode Links: Bioconcrete Revolution on PBS Grow Everything episode about bioconcrete: Biology is Hard. Bioconcrete is Harder. Prometheus Materials' Loren Burnett. Third Wave of Synbio by Massimo Portincaso What passenger pigeons look like Revive & Restore - Donate today! Gap in Nature by Tim Flannery and Peter Schouten Feathered River Across The Sky by Joel Greenberg Ben's Webinar: Passenger Pigeons. A Force for Forest Disturbance ViaGen animal and pets cloning company Informed biobanking protocols Bringing Science Fiction to Life: Not Boring created a Sci-Fi idea bank of 3500 sci fi ideas ready to be brought to life Call or Text the Grow Everything Hotline: +1 804-505-5553 Have a question or comment? Message us here: Instagram / TikTok / Twitter / LinkedIn / Youtube / GrowEverything website Email: groweverything@messaginglab.com Support here: Patreon Music by: Nihilore Production by: Amplafy Media --- Send in a voice message: https://podcasters.spotify.com/pod/show/messaginglab/message
This special episode features a panel discussion moderated by Chris Patil at the 2023 SynBioBeta conference. The panel brings together leaders from the synthetic biology and longevity communities to explore opportunities for collaboration and cross-pollination between these fields. Panelists discuss the talent bottleneck in longevity research, challenges in translating new discoveries into therapies, the need for improved communication and education, and a shared vision for transforming health and society. The conversation covers existing resources for learning about longevity science, as well as calls to build new communities and networks to accelerate progress. Overall, the panel makes a compelling case that by coming together, synthetic biologists and longevity advocates can achieve breakthroughs that neither field could accomplish alone.Guests:Nathan Cheng, Longevity Biotech FellowshipStephanie Dainow, Lifespan.ioDaniel Goodman, UCSFKat Kajderowicz, MIT/WhiteheadThe DetailsThe talent shortage in longevity research and need to attract people from outside the fieldChallenges in developing model systems and translating discoveries from simple organisms to humansThe role of improved communication, education and “edutainment” in enabling progressExisting online resources and communities in longevity science and synthetic biologyThe Time Fellowship and opportunities to get involved for students and early career researchersVisions for how synthetic biology could enhance longevity research, including new tools for measurement and diagnosticsHopes for progress in the short, medium and long term, from gaining years of healthspan to far future transformational changesThe importance of breaking down silos, incentivizing collaboration and taking action to achieve ambitious goalsQuotes:Quotations have been lightly edited for clarity.Nathan Cheng“A lot of people here asked me the difference between working on diseases of aging versus aging itself. And I think a lot of people aren't aware that age-related diseases like cardiovascular disease, Alzheimer's disease, even cancer — these are late-stage manifestations of the aging process itself.”“I think it's incumbent on us within the longevity community to go seek out the tool developers because they are inundated with all this interest from other players in other fields.”Stephanie Dainow“When it comes to aging, a lot of people you are under the impression that you're born, you will age there probably will be suffering, and then you will die. And that is the cycle of life. Right? That's kind of a standard. And I think this field is pushing that narrative in a direction that is uncomfortable because we're not used to it.”“Incentive structures matter. And in longevity, there aren't a lot of organizations that have products yet — forget the supplements, I'm talking about therapeutics — and that means that there aren't business development people, which means there's no selling, which means there's no marketing, which means there's no focus on articulation of the best way to create a narrative around the value prop.”Dan Goodman:“Synthetic biology has lots to offer, as far as measurement and diagnostics and being able to cheaply and at scale measure the effects of aging and the effects of longevity therapies on large populations.”“As we get more comfortable, and we get more and more skilled at deploying these tools for disease, it'll be to the point that healthy people will be willing to take these sorts of therapies. and we can do so much to modify the body and immune...
Plant biologists use a set of tools to modulate gene expression. The well-established set of molecular switches are rather crude, with limited control of spatial or temporal expression. Dr. James Lloyd discusses the newest tools in synthetic circuits, molecules that can tailor a response with a given input. These new tools add needed nuance to the regulation of gene expression and stand to revise how we control specific genes in the lab and field.
In the latest episode of "Grow Everything," hosts Erum and Karl are joined by renowned bioscience expert, Paul Freemont, to discuss the advancements and opportunities in the field of synthetic biology and biotechnology. Over the past five years, we've seen significant progression in this realm, particularly in terms of educational programs being implemented at universities across the globe. Also, there's been a push towards collaboration between rural and urban areas to create distributed manufacturing systems. Additionally, the integration of other disciplines such as art and design has played a crucial role in driving innovation forward. It is crucial for investors to educate themselves on the vast opportunities within this field. Furthermore, governments should provide incentives such as tax breaks to companies working in this space. In addition, technology has been utilized to reconnect with nature in a more sustainable way. The progress made in synthetic biology and biotechnology over the past five years is undeniable, and the future looks bright with many exciting possibilities on the horizon. Grow Everything brings to life the bioeconomy when hosts Karl Schmieder and Erum Azeez Khan share stories from the field and interview leaders and influencers in the space. Life is a powerful force and it can be engineered. What are we creating? Learn more at www.messaginglab.com/groweverything Topics Covered: Synthetic biology has a wide range of potential applications, including biofuels, air purification, and food and material production Advancements in AI communication have given us a head start in understanding and utilizing synthetic biology. The UK has seen significant growth in synthetic biology research since 2015. The maturity of the synthetic biology field has led to exciting entrepreneurial opportunities. Despite some progress, we still struggle with our dependence on petrochemicals. Understanding the language of life sciences is essential for further progress in synthetic biology. Exciting developments in bio-design and the use of biological materials as a design tool. Innovations in architecture that combat pollution, such as the work of Suzanne Lee. Building relationships through synthetic biology in Kenya and Ethiopia. The importance of incorporating biotechnology education into curricula at all levels. Episode Links: Paul Freemont LinkedIn Bio on Paul Freemont Synbicite Call or Text the Grow Everything Hotline: +1 804-505-5553 Have a question or comment? Message us here: Instagram / TikTok / Twitter / LinkedIn / Youtube / GrowEverything website Email: groweverything@messaginglab.com Support here: Patreon Music by: Nihilore Production by: Amplafy Media Topics: synthetic biology, entrepreneurship, policy, community, science education, biotech, life sciences, community biolabs, bioliteracy --- Send in a voice message: https://podcasters.spotify.com/pod/show/messaginglab/message
Synthetic biology technologies make it possible to create just about anything sustainably – including plants and fungal bioactives. Synbio has become a disruptive force that a growing number of companies are leaning into, including plant cell tech startup and Ginkgo Bioworks spinoff Ayana Bio. At the helm of the company is Frank Jaksch, who previously spent over two decades leading publicly-traded ingredient company ChromaDex.
Synthetic biology technologies make it possible to create just about anything sustainably – including plants and fungal bioactives. Synbio has become a disruptive force that a growing number of companies are leaning into, including plant cell tech startup and Ginkgo Bioworks spinoff Ayana Bio. At the helm of the company is Frank Jaksch, who previously spent over two decades leading publicly-traded ingredient company ChromaDex.
Jay Keasling is the Philomathia Professor of Alternative Energy at the University of California, Berkeley in the Departments of Bioengineering and Chemical and Biomolecular Engineering, senior faculty scientist at Lawrence Berkeley National Laboratory, and Chief Executive Officer of the Joint BioEnergy Institute (JBEI). Dr. Keasling's research focuses on the metabolic engineering of microorganisms for degradation of environmental contaminants or for environmentally friendly synthesis of drugs, chemicals, and fuels. Keasling received a B.S. in Chemistry and Biology from the University of Nebraska and M.S. and Ph.D. in Chemical Engineering from the University of Michigan, and did post-doctoral research in biochemistry at Stanford University. He is a member of the National Academy of Engineering and the National Academy of Inventors.Alix Ventures, by way of BIOS Community, is providing this content for general information purposes only. Reference to any specific product or entity does not constitute an endorsement nor recommendation by Alix Ventures, BIOS Community, or its affiliates. The views & opinions expressed by guests are their own & their appearance on the program does not imply an endorsement of them nor any entity they represent. Views & opinions expressed by Alix Ventures employees are those of the employees & do not necessarily reflect the view of Alix Ventures, BIOS Community, affiliates, nor its content sponsors.Thank you for listening!BIOS (@BIOS_Community) unites a community of Life Science innovators dedicated to driving patient impact. Alix Ventures (@AlixVentures) is a San Francisco based venture capital firm supporting early stage Life Science startups engineering biology to create radical advances in human health.Music: Danger Storm by Kevin MacLeod (link & license)
Can synthetic biology offer a more sustainable way to bring "natural" cosmetic ingredients to market? Can a branch of bioscience that includes the word synthetic in its name ever be considered natural? These are questions Formula Botanica CEO and podcast host Lorraine Dallmeier tackles in this opinion episode. Following her interview in the previous episode with Jake Wintermute, developer-evangelist at synthetic bioscience company Ginkgo Bioworks, Lorraine picks up on some valid comments and concerns of Green Beauty Conversations' listeners. Our recent episode with Dr Barb Paldus on biotech beauty – or lab-grown skincare – proved similarly controversial. Lorraine asks us to think carefully before we dismiss synbio and similar advances in biosciences as the anathema to natural cosmetics. Each of us must make up our own mind on these new frontiers in cosmetic science, and dig deep before deciding on what natural means to us. Listen in for a thought-provoking Green Beauty Opinion which might leave you with even more questions to answer.
Imagine a future in which bacteria is king and you might give a friend the skincare equivalent of a sourdough bread starter so they can grow their own moisturiser at home. Our podcast guest in this episode is on record as seeding this idea. We love the concept of cosmetic science being ever more in the hands of the home formulator, but is this concept just too futuristic? In this episode, Formula Botanica CEO and podcast host Lorraine Dallmeier, a biologist and Chartered Environmentalist, digs deeper into the world of lab-produced ingredients to investigate the field of synthetic biology. Lorraine interviews Jake Wintermute, developer-evangelist at US-based synthetic biology research company Ginkgo Bioworks who describes SynBio as genetic engineering on steroids. In Green Beauty Conversations, we recently covered another new frontier in cosmetic science – biotech beauty. It proved a controversial topic as many in our community felt that using lab-grow plant molecules as 'natural' cosmetic ingredients was a step too far. Listen in and use this episode as a primer to another new branch of science that could open up a revolution in cosmetic ingredients - or perhaps give us more to worry about?
This is an interview with Danko Nikolic and John Smart on the future of AI and their respective theories of Practopoiesis – Neuromimicry, and Autopoiesis – Biomimicry. During our 2-hour conversation with Danko and John, we cover a variety of interesting topics such as evolution, development, and life as a network; practopoiesis and the origins […]
Prof. Lewis Dartnell is an astrobiologist who looks for life on distant planets. In his most recent book, however, Dartnell turns his gaze inward and backward to the human story – who we are, how we came to be, where we are coming from, and, most importantly, how the geological planetary processes drove the evolution […]
Without a doubt, the social revolution in the West and individual insight/enlightenment in the East are among humanity's greatest accomplishments. But we can have them separate no longer for we desperately need both because individual people make society but, in turn, society makes individuals. We need to unite the quest for personal enlightenment and the […]
Two highly-recognized names in environmental media, Amy Harder (Cipher) and Heather Clancy (GreenBiz), sit down with Jennifer Holmgren to discuss why they became journalists, how covering climate has changed over the years, what challenges they face, what stories are not getting told but should, and much more. They ask each other powerful questions and leave the daisy-chain hook for Gearah Goldstein, founder of the GenderCool project.
Byron Reese is a serial entrepreneur, technologist, and futurist. He has enjoyed a wide range of success over 30 years, including two NASDAQ IPOs as well as the sale of three companies he founded. Today Byron is the CEO of JJ Kent, a venture-backed company using AI to create new products. Reese is also the author […]
Investment Director of FootPrint Coalition, Manuel Waenke and Sushmita Venkatraman, Director of Marking and Swami Srinivas, Director of Organism Engineering at Ginkgo Bioworks, Inc. join me at the Future Food-Tech for a discussion on the growth of the Plant-based Innovation Sector. It's another episode of The Plantbased Business Hour from the road. This time I hit NYC! Subscribe right now to never miss this podcast! For plant-based media/branding consulting and public speaking, reach out at elysabeth@elysabethalfano.com. For more information, visit ElysabethAlfano.com. Connect with Elysabeth on Linked in here: https://www.linkedin.com/in/elysabeth-alfano-8b370b7/ For more PBH, visit ElysabethAlfano.com/Plantbased-Business-Hour
Investment Director of FootPrint Coalition, Manuel Waenke and Sushmita Venkatraman, Director of Marking and Swami Srinivas, Director of Organism Engineering at Ginkgo Bioworks, Inc. join me at the Future Food-Tech for a discussion on the growth of the Plant-based Innovation Sector. It's another episode of The Plantbased Business Hour from the road. This time I hit NYC! Subscribe right now to never miss this podcast! For plant-based media/branding consulting and public speaking, reach out at elysabeth@elysabethalfano.com. For more information, visit ElysabethAlfano.com. Connect with Elysabeth on Linked in here: https://www.linkedin.com/in/elysabeth-alfano-8b370b7/ For more PBH, visit ElysabethAlfano.com/Plantbased-Business-Hour
Over the last 20 years, the idea of “designing biology” has gone from science fiction to just science, as the field of synthetic biology has exploded, with applications from therapeutics to manufacturing and more. In this episode from January 2019, one of the pioneers in the field, professor James J. Collins of MIT, joins a16z general partner on the Bio + Health fund, Vijay Pande, and editorial partner Hanne Winarsky, to discuss the origins of synthetic biology or "synbio", to what "engineering and designing" biology really looks like in action and the disciplinary differences between how biologists and engineers see the world.
Steve Jobs once said that the biggest innovations in the 21st century would be at the intersection of biology and technology. Nature offers tantalizing examples of the magical properties of biology—self-assembly, self-repair, self-replication and more. Jason Kelly, co-founder and CEO of Ginkgo Bioworks, shares his dream of harnessing nature by reading and writing DNA to program cells like we program computers.Ginkgo is a synthetic biology company that programs cells for customers in the pharmaceutical, food, agriculture and energy industries.
I have always wanted to discuss Friedrich Nietzsche's philosophy and how it relates to technology and transhumanism. The problem is that a very short list of people will make me enjoy such a challenging conversation. Luckily, Dr. Cadell Last is among the top on that shortlist. I hope you enjoy our conversation as much as […]
Joscha Bach is a beautiful mind and a very rewarding interlocutor. No surprise I had many requests to have him back on my podcast. I apologize that it took 4 years but the good news is we are going to have a third conversation much sooner this time around. If you haven't seen our first […]
The opener to Season 2 features young children in the lives of LanzaTech's team asking questions on climate change, biodiversity, sea level rise, and more, for responses by our CEO and expert Hunter Lovins. Held annually on June 5th, World Environment Day is the largest global platform for public outreach. This 2022 theme, “Only One Earth,” was the slogan for the first United Nations Conference on the Human Environment, held in 1972.
Faith Popcorn founded her futurist marketing consultancy in 1974. She's been called “The Trend Oracle” by the NY Times and “The Nostradamus of Marketing” by Fortune. Faith is a trusted advisor to the CEOs of Fortune 200 companies and has predicted a variety of trends such as Cocooning and its impact on the COVID culture, […]
Dr. Kendall Haven is the only West Point graduate to ever become a professional storyteller. Haven holds a Doctorate in Oceanography and spent eight years as a Senior Research Scientist for the Department of Energy before finding his true passion for what he calls, a very different kind of “truth.” Kendall is the author of 34 […]
Brian Boyd is a Distinguished Professor at the University of Auckland in New Zealand. His work has appeared in 20 languages and has won awards on four continents. Most importantly, Prof. Boyd is the author of On the Origin of Stories which examines the connections between evolution, cognition, and fiction. During our 2-hour conversation with […]
Kat Kajderowicz is a PhD student at MIT interested synthetic biology, aging, neuro, and science communication. Check out her #SynBio journal club (@DnaDeviants on Twitter).
John Smart has taught and written for over 20 years on topics like foresight and futurism as well as the drivers, opportunities, and problems of exponential processes throughout human history. John is President of the Acceleration Studies Foundation, co-Founder of the Evo-Devo research community, and CEO of Foresight University. Most recently, Smart is the author […]
LanzaTech CEO Jennifer Holmgren calls Jim Messina — the mastermind behind Obama's 2012 reelection campaign — the world's most successful political and corporate advisor. Throughout his career, he has merged technology and politics in a way that's been unpredictable and unprecedented. For over 20 years, Jim served in House and Senate offices, helping pass key legislation. Here, he shares why the public and private sectors must support one another, particularly for momentum on climate action.
Jonah Sachs is an author, speaker, and viral marketing pioneer. He helped create some of the world's first and most heralded digital social change campaigns. Jonah Sachs is also the author of Winning the Story Wars: Why Those Who Tell (and Live) the Best Stories Will Rule the Future and, most recently, Unsafe Thinking: How […]
Natural First-Aid Healing: https://3rdrockessentials.com, use code DAVE to save 20%Non-Tobacco Nicotine Alternative: https://lucy.co, use code DAVE20 to get 20% off your first order of pouches, gums, or lozengesBiostack for High Performance: https://vatellia.com, use code DAVE2022 to save 10% or subscribe and save 15% + receive a free bottle of Kale BusterIN THIS EPISODE OF THE HUMAN UPGRADE™...… you'll get a look at synthetic biology (SYNBIO) through the lens of quantitative futurist Amy Webb in Part 2 of a special two-part episode. The Part 1 episode #913 explores the scientific perspective with microbiologist and geneticist Andrew Hessel.Amy and Andrew recently authored, “The Genesis Machine: Our Quest to Rewrite Life in the Age of Synthetic Biology.” SYNBIO is the promising and controversial technology platform that combines biology and artificial intelligence. Amy investigates what SYNBIO means for people, commerce and the planet. “This is a book about science,” Amy describes, “but I did not want to write a science book. This is also a business book. It's an understanding-your-own-body book.”She's a futurist who works with data and does predictive modeling. Her academic background includes game theory and economicsAmy founded the Future Today Institute to help companies understand the forces that will shape their futures. She's a professor of strategic foresight at the NYU Stern School of Business and a Visiting Fellow at Oxford University's Säid School of Business. She writes extensively about biotechnology, artificial intelligence, technology policy, and business strategy.“This emerging field of science—synthetic biology—promises to reveal how life is created and how it can be recreated, for many varied purposes, as explained in “The Genesis Machine:”to help us heal without prescription medications, to grow meat without harvesting animals, and to engineer our families when nature fails us.With SYNBO developments come a slew of considerations about how to manage it responsibly.“For the most part, in the US, the regulation is on the end product,” Amy says. “Nobody wants to regulate the process, because we don't want to hamper innovation. However, it does start to raise some gnarly questions when we're talking about alternative uses or different uses for some of these technologies, or cross-border use.”“There's some alignment globally on what's called germline editing, which is when you edit the genome to make it heritable. So whatever that is passes on. At the moment, just about 190 countries have aligned [to agree] that they don't want that to happen. But outside of that, there's a lot of confusion.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Many of you know that I've been working on a new book provisionally titled ReWriting the Human Story: How Our Story Determines Our Future. And so I thought it could be useful to me and interesting to you if I were to have a conversation with a few story experts and ask them questions such […]
Many of you know that I am a fan of Buddhism in general and Zen Buddhism in particular. So I've always wanted to get a Zen Master on the podcast. I never imagined, however, that there is a Zen Master who has listened to almost every episode of my show. But the universe is a […]
Prof. Angus Fletcher is a story scientist working at the intersection of story and neuroscience. Angus started as a neuroscientist at the University of Michigan but eventually decided to pursue a Ph.D. in Shakespeare at Yale. Then he went to Stanford University and worked with clients in Hollywood, DARPA, and the US special forces. Angus […]
This is the second interview of my series on story and my guest is PJ Manney. PJ is the author of the Phoenix Horizon Trilogy and has already been a guest on Singularity.FM twice before. [See our 1st and 2nd interviews.] She is a friend, and I am a big fan of her books. Today we […]
Some of you may know that I've been working on a new book. The provisional title is ReWriting the Human Story: How Our Story Determines Our Future. Struggling with this book is why it's been a number of months since my last podcast interview. And so I thought it could be useful to me and […]
Hear from Professor Jim Collins of MIT how synthetic biology helped us detect and mitigate the COVID-19 pandemic and how it can help prevent future pandemics.
Miroslav Gasparek is a PhD candidate in engineering science at Oxford University. He's also a venture fellow at Civilisation ventures, and part of the steering committee at the European Union SynBio society. Miro's research lies at the intersection of SynBio, control theory and data-driven control methods like reinforcement learning. He's interested in the practical applications of SynBio, its wider impact and providing solutions to real-life problems. As well as understanding how meaningful and live-saving innovations get to the market. Topics explored in this week's episode:-How does a life scientist get interested in Venture Capital?-How to formally analyse an investment opportunity in Synthetic Biology-Why are there more challenges for raising capital for SynBio companies in Europe when compared to the US?-Miro's research journey as well as Fellowship experience at Newton Ventures and Civilisation Ventures.Miro's website: https://www.miroslavgasparek.com/pages/about.html