Podcasts about chromadex

In this episode, we sit down with Rob Fried, an Academy Award and Emmy Award-winning motion picture producer and, since 2018, the CEO of ChromaDex. Although he has interests in media and business, Rob also has an immense passion for health and wellness – specifically, the science of anti-aging… ChromaDex is a global bioscience company dedicated to healthy aging. Their team comprises world-renowned scientists pioneering research on nicotinamide adenine dinucleotide (NAD+), a coenzyme critical to metabolism health that declines with age. By creating a breakthrough ingredient commercially known as Niagen®, Rob and his team have one central goal to fulfill: To help the world age better. Join us now to discover: The best ways to elevate your NAD+ levels. How to improve the body's ability to manufacture energy. Mechanisms that contribute to the production of NAD+. Common mitochondrial dysfunctions that can cause fatigue. To learn more about Rob and his work with ChromaDex, click here! Episode also available on Apple Podcast: http://apple.co/30PvU9C

This Academy & Emmy Award Winning CEO Wants You To Age Better. Robert Fried CEO ChromaDex - $CDXCGuest:Robert Fried CEO ChromaDex - $CDXCWebsite:https://www.chromadex.com/Ticker: $CDXCBio:Robert Fried is the CEO of ChromaDex and Founder of Tru Niagen as well as an Academy Award® and Emmy® Award winning motion picture producer. Before his combined 7 years in the health industry, he held senior roles at entertainment companies Savoy Pictures (CEO), Columbia Pictures (Executive Vice President), and Fried Films (founder, CEO). He has also founded and served as CEO of internet companies Feeln (now Hallmark Movies Now), WHN (a leading e-commerce service provider), and Healthspan Research LLC. In 2017, Robert led ChromaDex's acquisition of Healthspan Research LLC, a consumer company offering Tru Niagen products, and raised funds with Horizons Ventures to offer Tru Niagen direct-to-consumer. Since 2017, Mr. Fried has maintained his position as CEO of ChromaDex, now the global authority on NAD+, and Founder of Tru Niagen, currently the number one healthy aging NAD+ supplement in the US helping people around the world transform the way they age. Mr. Fried holds a B.S. from Cornell University and an M.B.A. from the Columbia University Graduate School of Business.

For the past 25 years, Chromadex has been at the forefront of innovation and research in healthy aging. Rob Fried, the company's CEO, reflects on its evolution from an analytical testing service to a developer of proprietary ingredients, with a particular focus on NAD precursors like nicotinamide riboside (NR).

Those who watch the long running reality dating show franchise, ABC's The Bachelor, know that the women on it go the distance for a chance at love; and former contestant Clare Crawley is no exception. Clare is best known as the Runner Up in Season 16 of the series, leading to her role as ABC's Bachelorette in Season 18. She also appeared on Bachelor in Paradise twice and Winter Games, making her one of the most recognizable cast members in The Bachelor franchise. But in recent years, Clare has been known for something else – making headlines because of her fertility struggles.She first came out with her vulnerable fertility story via Instagram, when she was finally expecting via gestational surrogacy by sharing, “I can tell you how hard it has been to hold the secret as I've shared the last 10 years of my life with you all. This is one journey, though, that Ryan and I have been keeping close to our hearts as we navigated the uncertain world of IVF and all that comes with it….” Clare concluded the post by thanking her fertility specialist, Dr. Aimee “The Egg Whisperer” for ‘helping miracles happen'.Clare's doctor, Dr. Aimee Eyvazzadeh, joins our episode midroll to share more about how she worked with Clare and with other patients in her practice, many of whom are over 40 years old, and why she puts all of her patients on the clinically proven NAD plus boosting supplement, Tru Niagen.Tru Niagen, the episode sponsor, was developed by ChromaDex, and their Scientific Director, Mona Rosene also joins the episode midroll break to share more on the scientific standards of Tru Niagen and why people navigating reproductive journeys and who want to support healthy aging may want to consider taking the supplement. Pregnantish listeners! If you want to try Tru Niagen, use EGGCELLS20 for 20% off at truniagen.com Hosted on Acast. See acast.com/privacy for more information.

Subscribe to our channel: https://www.youtube.com/@optispan Check out the Brenner lab: https://brennerlab.net Related episodes: The Benefits of Protein Restriction, How Protein Affects Hormones & FGF21: https://youtu.be/Nf1GhkAFiWY Matt and City of Hope Alfred E. Mann Family Foundation Chair of Diabetes and Cancer Metabolism Charles Brenner have had several public disagreements on social media. We love a good conversation between two distinguished scientists whose views may not entirely align, so we were pleased to host Charles on the Optispan Podcast for a discussion of topics in geroscience ranging from whether sirtuins are actually longevity regulators to the clinical utility of epigenetic age tests to the incentive structures around clinical trials. We also spent a chunk of time on NAD+ boosters, one of Charles' areas of expertise, and their relevance to aging and other conditions such as COVID-19. Prior to his City of Hope appointment, Charles served on the faculties of Thomas Jefferson University, Dartmouth College, and the University of Iowa, where he was the Roy J. Carver Head of Biochemistry for 11 years. He currently serves as the Chief Scientific Advisor of the biotechnology company ChromaDex, which uses his nicotinamide riboside (NR) intellectual property. He is also a cofounder of biotechnology companies Alphina and Juvenis. Charles conducted postdoctoral research at Brandeis University and received a PhD and a B.A. from Stanford University and Wesleyan University respectively. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/

In this Good For You: University episode, Whitney gets all the intel on fertility from Dr. Aimee, fertility doctor (aka The Egg Whisperer) and Tru Niagen Partner. Whitney credits becoming pregnant at 40 to the NAD booster. They discuss the negative impact of environmental toxins and stress on fertility, and Dr. Aimee explains how women can increase their chances of getting pregnant. Developed by ChromaDex, a pioneer in NAD+ with a focus on healthy aging research, Tru Niagen is the number one NAD+ supplement in the United States. Helping people around the world transform the way they age, Tru Niagen is clinically proven to increase NAD+ and features patented nicotinamide riboside, the most efficient and superior-quality NAD+ precursor available. Setting the gold standard in scientific rigor and quality Tru Niagen is backed by two Nobel Prize winners, 30+ human clinical studies, and 300+ published scientific studies, and has been accepted by the world's most rigorous regulatory bodies. TRU NIAGEN https://www.truniagen.com/products/? Discount Code: agingsucks20

In this episode, we sit down with Rob Fried, an Academy Award and Emmy Award-winning motion picture producer and, since 2018, the CEO of ChromaDex. Although he has interests in media and business, Rob also has an immense passion for health and wellness – specifically, the science of anti-aging… ChromaDex is a global bioscience company dedicated to healthy aging. Their team comprises world-renowned scientists pioneering research on nicotinamide adenine dinucleotide (NAD+), a coenzyme critical to metabolism health that declines with age. By creating a breakthrough ingredient commercially known as Niagen®, Rob and his team have one central goal to fulfill: To help the world age better. Join us now to discover: The best ways to elevate your NAD+ levels. How to improve the body's ability to manufacture energy. Mechanisms that contribute to the production of NAD+. Common mitochondrial dysfunctions that can cause fatigue.  To learn more about Rob and his work with ChromaDex, click here! Take advantage of a 5% discount on Ekster accessories by using the code FINDINGGENIUS. Enhance your style and functionality with premium accessories. Visit bit.ly/3uiVX9R to explore latest collection. Episode also available on Apple Podcast: http://apple.co/30PvU9C

Today we have a to-the-point, super informative episode. Beth interviews Mona Rosine, she is Global Director at Chromadex, who are the makers of TruNiogen, a great aid in supporting cellular function. Mona is a dietician, nutritionist, and she'll introduce herself in longer form. But we want you to know that this is a very important topic that you should all know about so that you understand how to get maximum power, efficiency and health from your physical body and also how that will impact your mental health.  Disclaimer: The content of this podcast is for informational purposes only and should not be considered a substitute for medical treatment, or advice, and shall not make any health or medical-related decision based in whole or in part on anything contained in the site. The opinions expressed by the guests do not necessarily reflect the views of Beth Shaw or YogaFit.

Dr. Willie Soon – an astrophysicist, geoscientist, and expert on solar phenomena and global climate – was attacked online after making controversial statements about his climate change research in a recent Tucker Carlson interview. Dr. Willie Soon (aka Dr. Wei-Hock Soon) is an astrophysicist and geoscientist. He is a leading authority on the relationship between solar phenomena and global climate. In 2018, he founded the Center for Environmental Research and Earth Sciences (CERES-science.com) in order to tackle a wider range of issues and topics without fears nor prejudices. From 1991-2022, Dr. Soon was an astrophysicist at the Solar, Stellar and Planetary Sciences Division of the Harvard-Smithsonian Center for Astrophysics. He served as receiving editor for New Astronomy from 2002-2016, astronomer at the Mount Wilson Observatory from 1992-2009. Dr. Soon earned bachelor's and master's degrees in science and a Ph.D. in aerospace engineering from the University of Southern California. Learn more at https://ceres-science.com/ and watch his videos at https://youtube.com/@ceresscience6032 「 SPONSORED SEGMENT FROM CHROMADEX 」 Dr. Charlie Brenner is a scientific advisor for Chromadex. Learn more at https://chromadex.com 「 SPONSORED BY 」 Find out more about the companies that make this show possible and get special discounts on amazing products at https://drdrew.com/sponsors • PET CLUB 24/7 - Give your pet's body the natural support it deserves! No fillers. No GMOs. No preservatives. Made in the USA. Save 15% at https://drdrew.com/petclub247 • PROVIA - Dreading premature hair thinning or hair loss? Provia uses a safe, natural ingredient (Procapil) to effectively target the three main causes of premature hair thinning and hair loss. Susan loves it! Get an extra discount at https://proviahair.com/drew • GENUCEL - Using a proprietary base formulated by a pharmacist, Genucel has created skincare that can dramatically improve the appearance of facial redness and under-eye puffiness. Get an extra discount with promo code DREW at https://genucel.com/drew • THE WELLNESS COMPANY - Counteract harmful spike proteins with TWC's Signature Series Spike Support Formula containing nattokinase and selenium. Learn more about TWC's supplements at https://twc.health/drew 「 MEDICAL NOTE 」 Portions of this program may examine countervailing views on important medical issues. Always consult your personal physician before making any decisions about your health. 「 SCIENCE NOTE 」 The World Health Organization states that climate change is directly contributing to humanitarian emergencies from heatwaves, wildfires, floods, tropical storms and hurricanes. Portions of this program may examine countervailing views on controversial issues. 「 ABOUT THE SHOW 」 Ask Dr. Drew is produced by Kaleb Nation (https://kalebnation.com) and Susan Pinsky (https://twitter.com/firstladyoflove). This show is for entertainment and/or informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment. 「 ABOUT DR. DREW 」 Dr. Drew is a board-certified physician with over 35 years of national radio, NYT bestselling books, and countless TV shows bearing his name. He's known for Celebrity Rehab (VH1), Teen Mom OG (MTV), The Masked Singer (FOX), multiple hit podcasts, and the iconic Loveline radio show. Dr. Drew Pinsky received his undergraduate degree from Amherst College and his M.D. from the University of Southern California, School of Medicine. Read more at https://drdrew.com/about Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode is brought to you by Compass Rose Ventures  and SARAL  - The Influencer OS for Brands Today, host Ramon Vela interviews Rob Fried, CEO of ChromaDex and maker of Tru Niagen®.  ChromaDex is the global authority on nicotinamide adenine dinucleotide (NAD+), focusing on the science of healthy aging.  The ChromaDex team, including world-renowned scientists, works with independent investigators from esteemed universities and research institutions around the globe to uncover the full potential of NAD+. A vital coenzyme found in every cell of the human body, NAD+ declines with age and exposure to other everyday stressors, making NAD+ a contributor to age-related changes in health and vitality.  ChromaDex is the innovator behind Tru Niagen®, its growing suite of clinically proven, top-selling NAD+ boosting supplements helping people transform the way they age worldwide.  Setting the benchmark as the gold standard in scientific rigor, quality, and transparency, Tru Niagen features patented nicotinamide riboside (NR), the most efficient and superior quality NAD+ boosting supplements available. Tru Niagen is backed by two Nobel Prize Winners, 30+ human clinical studies, and 300+ published scientific studies, and has been accepted by the world's most rigorous regulatory bodies. Highlights: * His history in the entertainment business and producing movies * Business lessons, including his “Principles of Success: CHE and ACE” * What does Tru Niagen® do? * How NAD is vital for mitochondrial function and energy metabolism * The main ingredient in Tru Niagen® * Why NAD is fundamental to life * How Tru Niagen® enables the body to do what it's supposed to do * The applications for Tru Niagen® * When to take Tru Niagen® * Healthspan versus lifespan? * Vitamins versus Tru Niagen®? What gives your cells actual energy? * When do your NAD levels increase after taking Tru Niagen®? * Rob's personal experience with taking the supplement Tru Niagen® * What people are saying about Tru Niagen® * How to know if Tru Niagen® is working * And so much more…  Join Ramon Vela and Rob Fried as we break down the inside story of ChromaDex on The Story of a Brand. For more on ChromaDex, visit: https://www.chromadex.com/ For more information on Tru Niagen®, visit: https://www.truniagen.com/ Discount code: If you want to sample Tru Niagen 300mg 30 count subscription, you can get a 15% discount here. Simply use promo code: RAMON15   Or Click Here https://www.truniagen.com/truniagen-300mg/?utm_source=Story+of+a+Brand&utm_medium=Podcast&utm_campaign=Interview&utm_term=truniagen Subscribe and listen to the podcast on all major apps. Search for “The Story of a Brand” on your favorite podcast player. * Today's Sponsors: SARAL  - The Influencer OS for Brands: http://storybrandoffer.com/ Claim an "exclusive onboarding" offer for the listeners of The Story of a Brand Show. The Saral Team will work directly with you and offer weekly check-ins and 1:1 consulting until you succeed. Visit my unique link. 

He's brought some of your favorite movies and television shows for more than thirty years... now he's out to help you live forever. On today's episode Robert Fried visits with the docs to discuss his passion for longevity and his work in developing TruNiagen, a leading supplement in the world of health and wellness. Prepare to be blown away, only on Forever Young! Save some bucks on your Tru Niagen aka 'fountain of youth in a bottle' here: http://bit.ly/ForeverYoung15 and use promo code FOREVERYOUNG15. ChromaDex & Tru Niagen overview: ChromaDex is the global authority on nicotinamide adenine dinucleotide (NAD+) with a focus on the science of healthy aging. The ChromaDex team, inclusive of world-renowned scientists, works with independent investigators from esteemed universities and research institutions around the globe to uncover the full potential of NAD+. A vital coenzyme found in every cell of the human body, NAD+ declines with age and exposure to other everyday stressors, making NAD+ a contributor to age-related changes in health and vitality.  ChromaDex is the innovator behind its clinically proven, gold standard consumer supplement Tru Niagen®, patented nicotinamide riboside (NR), the most efficient and superior-quality NAD+ boosters available. Tru Niagen is a growing suite of clinically proven, top-selling healthy aging supplements helping people around the world transform the way they age, available at www.truniagen.com.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Discover the longevity secret everyone's buzzing about NAD+ with a panel of top experts. In this episode I'm joined by 5 experts to discuss NAD+: Dr. Darshan Shah, founder of Next Health and a longevity expert; Dr. Aimee, aka the Egg Whisperer, who is a fertility doctor and OB-GYN, Todd Anderson, founder of Dream Recovery, a performance coach and a sleep expert, Brooke Burke, fitness expert and host personality, and Dr. Abe Malkin, founder of Drip Hydration, concierge doctor and also a longevity expert.  We discuss the crucial role of NAD for cellular health and energy production, the importance of choosing high-quality, research-backed supplements, and daily habits for enhanced well-being. What we discuss: (0:00:01) - The importance of NAD and its rise in popularity among celebrities and biohackers, the significance of NAD in maintaining energy as we age, and its role in various cellular functions (0:11:56) - The natural methods to boost NAD levels, such as high-intensity training and proper nutrition, and the controversy surrounding NAD precursors NR and NMN (0:18:13) - The complexities of the supplement industry, the necessity of research and trust in manufacturers is underscored due to the alarming findings of ChromaDex's analysis of NMN products, the signs of NAD deficiency, and the optimal age for supplementation. (0:29:33) - Daily habits and routines for health and longevity from the experts (0:35:35) - How to dose NAD Thank you to our sponsor: Therasage: Head over to therasage.com and use code Be Bold for 15% off Find more from Jen: Website: https://www.jennifercohen.com/ Instagram: @therealjencohen Books: https://www.jennifercohen.com/books Speaking: https://www.jennifercohen.com/speaking-engagements Learn more about your ad choices. Visit megaphone.fm/adchoices

On the latest episode of Petworking, I was fortunate enough to be joined by

Robert Fried is the Chief Executive Officer (CEO) of ChromaDex. Mr. Fried is an Academy Award and Emmy Award winning motion picture producer. He has held senior roles at entertainment companies Savoy Pictures (CEO), Columbia Pictures (Executive Vice President) and Fried Films (founder, CEO). He has also founded and served as CEO of internet companies Feeln (now Hallmark Movies Now), WHN (a leading e-commerce service provider), and Healthspan Research (now part of ChromaDex). Mr. Fried holds a B.S. from Cornell University and a M.B.A. from the Columbia University Graduate School of Business. In this episode of the BriteVibe podcast, Rob shares his background, which includes working with Hallmark and being involved in the production of movies like Rudy. The conversation dives into topics such as living optimally, brain health, slowing down aging and optimizing biological functions. Tune in to learn more about Rob's transition and his insights on health and wellness. Learn more from Rob Fried and TRU NIAGEN, please visit https://www.truniagen.com/. Use coupon code TAKE20 for $20 off orders $100 or more.   [00:01:48] Movie producing and Hallmark.  [00:08:28] Telomere technology and anti-aging. [00:14:17] Elevating NAD for anti-aging.  [00:22:03] People's life-changing experiences.  [00:27:52] Hair and nail growth.  [00:32:38] NAD and health span.

When Brianna Gerber tells us that during earnings season at Mattel, Inc., she was once known as the investor relations person most likely to be “knocking on doors,” we can't help but want to learn more about her IR tour of duty for the toy giant.   “I'd be calling on the marketing team and the commercial team, talking to treasury and tax, and asking them all ‘What's really going on?' because I would need to understand the numbers before I could explain them,” recalls Gerber, who occupied Mattel's corridors for nearly five years, after having spent 10 years as an equity research executive. There's little doubt here that Gerber is sharing a fond memory that exposes the somewhat immediate satisfaction that she experienced upon landing inside a corporate entity. The glass wall through which she had once peered as an equity analyst had vanished, and she was now able to engage one-on-one with the senior leaders best able to explain the complexities of the business. It's a recollection that also reveals the door-opening presence that IR executives enjoy. Still, Gerber wanted something more, and while the IR career track at Mattel no doubt would offer her accelerated advancement, she instead decided to make a lateral move to Mattel's FP&A team. “Ultimately, this was about me having the confidence in myself to say, ‘I understand the numbers and I understand why they tell a story, so I can now translate what I learned from this 30,000-foot view and use it to allow me to at the same time go even deeper,” remarks Gerber, who continued her career climb inside Mattel's FP&A function for a number of years before being recruited by Kevin Farr, Mattel's long-tenured CFO, who had exited the toy maker in 2017 to serve as CFO of ChromaDex, a pioneering biotech firm. At ChromaDex, with the two worlds of investor relations and FP&A under her purview, Gerber became a direct report to Mattel's veteran CFO—a coveted opportunity for mentoring if ever there was one.   “I think that what brought Kevin here and what brought me here was in part the potential to build something,” comments Gerber, who would step into the CFO office at ChromaDex in August of 2022. Looking back on her career pivots from equity research to IR to FP&A, Gerber highlights her personal goal of seeking challenge. She adds: “I think that we are constantly reinventing ourselves, and this is what keeps our careers interesting.” –Jack Sweeney 

LifeBlood: We talked about how to live better and longer, what NAD is and how it impacts metabolism, how to become more physically resilient, and how to restore damaged cells, with Dr. Charles Brenner, Chief Scientific Advisor at ChromaDex, researcher and healthy aging advocate.    Listen to learn why aging is a privilege! You can learn more about Charles at BrennerLab.net, TruNiagen.com, Chromadex.com, Twitter and LinkedIn. Use discount code TAKE20 for $20 off purchases $150 or more. “These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.” Thanks, as always for listening! If you got some value and enjoyed the show, please leave us a review here: ​​https://ratethispodcast.com/lifebloodpodcast You can learn more about us at LifeBlood.Live, Twitter, LinkedIn, Instagram, YouTube and Facebook or you'd like to be a guest on the show, contact us at contact@LifeBlood.Live.  Stay up to date by getting our monthly updates. Want to say “Thanks!” You can buy us a cup of coffee. https://www.buymeacoffee.com/lifeblood

Meet Charles Brenner, the Longevity Skeptic. Brenner, a leading biochemist at City of Hope National Medical Center in L.A., has been attending the largest longevity conferences with one main purpose: to point out that some of the other speakers are full of it.Brenner is "throwing cold water" on several scientists in the field of aging, accusing them of hyping various fountains of youth, despite limited evidence for these therapies.In this podcast episode, Brenner sat down with Leaps.org to discuss his groundbreaking work on metabolism and his efforts to counter what he considers to be bad science.In addition to bringing his candor to conferences, Brenner is applying it in academic journals, publishing a paper in September, "A Science-Based Review of the World's Best-Selling Book on Aging," in which he pans the author of this bestseller, David Sinclair, a Harvard biologist, for talking up the potential for humans to live far past 100. These aspirations may sound nice, but they're not backed by science, Brenner says. He's had high-profile debates online with Sinclair and Aubrey de Grey, a prominent biomedical gerontologist.Meanwhile, in his own lab work, Brenner is credited with identifying a vitamin precursor called NR that seems to enable repair of cellular damage that happens as we get older - a major discovery that he's helped turn into a supplement, commercialized with a company called ChromaDex.Whether it's possible to extend human lifespan is a pressing question as investments in longevity startups are projected to increase from $40 billion to $600 billion over the next three years. Brenner is an intriguing figure in these debates. Although he's been introduced in public appearances as a longevity skeptic, he calls himself an optimist.Links:Charles Brenner, City of HopeCharles Brenner LabCharles Brenner on TwitterCharles Brenner's debate with Aubrey de GreyBrenner's paper, "A Science-Based Review of the World's Best-Selling Book on Aging"Leaps.org is a not-for-profit initiative that publishes award-winning journalism, popularizes scientific progress on social media, and hosts events about bioethics and the future of humanity. Visit the platform at www.leaps.org. Podcast host Matt Fuchs is editor-in-chief of Leaps.org.

Synthetic biology technologies make it possible to create just about anything sustainably – including plants and fungal bioactives. Synbio has become a disruptive force that a growing number of companies are leaning into, including plant cell tech startup and Ginkgo Bioworks spinoff Ayana Bio. At the helm of the company is Frank Jaksch, who previously spent over two decades leading publicly-traded ingredient company ChromaDex.

Synthetic biology technologies make it possible to create just about anything sustainably – including plants and fungal bioactives. Synbio has become a disruptive force that a growing number of companies are leaning into, including plant cell tech startup and Ginkgo Bioworks spinoff Ayana Bio. At the helm of the company is Frank Jaksch, who previously spent over two decades leading publicly-traded ingredient company ChromaDex.

In this special leadership series, we're getting to know industry veterans and changemakers.Greg Arabatzis, Vice President Practitioner Division, discusses what sets ChromaDex apart from the competition. Learn more! https://wholefoodsmagazine.com/column...   This content is sponsored by Chromadex. Visit their website https://www.chromadex.com/

Todd Pauli of 24 Stories Marketing and Maggie Jaqua of WholeFoods Magazine talk with Greg Arabatzis, VP of Healthcare Pracitioner Sales with ChromaDex, about industry trends, fostering powerful connections, working with influencers, and the benefits of Tru Niagen for sports nutrition.

This episode is loaded with ways to consider slowing down your cellular aging. My special guest is Dr. Charles Brenner, the world's leading expert on NAD metabolism. Dr. Brenner is known for discovering the Nicotinamide Riboside pathway that leads to this special NAD molecule. Dr. Brenner is also the Alfred E Mann Family Foundation Chair of Diabetes & Cancer Metabolism at City of Hope in Los Angeles, California and Chief Scientific Advisor for ChromaDex, which has developed an ingredient called Tru Niagen on the basis his work on Nicotinamide Riboside.Dr. Brenner is a valued skeptic on overreaching claims about longevity genes and lifespan extension but an advocate for physical and mental activity and what he calls following mom's advice: eat your vegetables, don't smoke or do drugs, etc.

My guest on episode 42 of the podcast is Dr. Charles Brenner Dr. Brenner is the Alfred E Mann Family Foundation Chair in Diabetes and Cancer Metabolism at City of Hope National Medical Center.  In 2004, Brenner discovered nicotinamide riboside (NR) to be a vital precursor of nicotinamide adenine dinucleotide (NAD+), which is made available by nicotinamide riboside kinases (Nrks) that are conserved between yeast and humans. In 2007, Dr. Brenner's lab discovered a second pathway by which NR is converted to NAD+ and showed that NR can extend the lifespan of yeast cells by virtue of elevating NAD+ levels and increasing the activity of the NAD+-dependent Sir2 enzyme. In the past decade, Dr. Brenner has made multiple seminal contributions to NAD+ metabolism, which include engineering a yeast strain to convert inexpensive NAD+ precursor vitamins into NR, solving the crystal structure of human Nrk1, developing the methods for quantitative NAD+ metabolomics, and demonstrating the activity of oral NR in animal models of fatty liver disease; obesity; type 2 diabetes; diabetic and chemotherapeutic neuropathy; heart failure; and central brain injury. Dr. Brenner also led the first clinical trial of NR, which established safe oral availability in humans. He is currently focusing on the maternal and neonatal effects of oral NR and translating animal discoveries into evidence-based safe, human clinical practice for human conditions of metabolic stress. Dr. Brenner is clearly a well-credentialed scientist, but my main impetus for inviting him to come on the podcast is his recent public criticisms of the longevity field. In particular, Dr. Brenner has several recent posts in which he has directly called out prominent longevity scientist Dr. David Sinclair for what Dr. Brenner describes as spreading misinformation regarding what we know about aging and whether or not we can slow or reverse aging. We spend the last 20 minutes or so of the podcast discussing his critiques and where he believes scientists in the longevity field may be overstepping. Other topics that we get into include some basics on human metabolism, nicotinamide adenine mononucleotide (also known as NAD) and the importance of the NAD system in physiology, what types of things perturb the NAD system and how this may contribute to diseases and aging, and ways we might be able to boost the NAD system through diet and supplementation. I will say that at times, we got pretty technical in this podcast, and Dr. Brenner gets into some of the more complex biochemistry surrounding metabolism and the NAD system. But I really encourage you to listen to everything we chat about, because Dr. Brenner is such an eloquent speaker about these topics and I think that even if some concepts are higher level, you'll learn a lot about biology and physiology through what he has to say — I surely did.  If you enjoy this podcast and would like to support it, there are several ways to do so. The first way is by becoming a supporter of Patreon. With Patreon, you can support the podcast with a monthly donation at any level you'd like. You can start showing your support right now by going to patreon.com/bradyholmer or checking the show notes for a link to my Patreon page. You can also make a one-time donation to help support the podcast through PayPal or Venmo. These support options can be found on my website by going to bradyholmer.com/donate. There's also a link in the show notes to the support page. Finally, checking out the podcast sponsors is also a fantastic way to show your support. There are two partners for today's podcast, both of which are products I use frequently and absolutely love. The first is LMNT electrolyte drink mix. LMNT is a sugar-free, carbohydrate-free and tasty drink mix containing scientifically-based amounts of sodium, potassium, and magnesium. The single serve packets are great to add to water for any time around a workout or just to have throughout the day. I'm routinely using about 3 of these each day. LMNT comes in a variety of flavors including citrus salt, raspberry, and watermelon. You can try a free 8 pack sampler of LMNT by going to drinklmnt.com/scienceandchill or checking the show notes for a link to this special offer. I've also partnered with health via modern nutrition (HVMN) to bring a special offer for my audience on their brand-new ketone IQ ketone drink. Ketones are sometimes called the “fourth fuel” and can be used by our muscles, heart, and brain for energy. With exogenous ketone drinks like ketone IQ, you can rapidly elevate your blood ketones and put your body into a state of ketosis. Studies have found — and I have experienced — that taking ketones can help with mental performance and clarity, athletic performance, and maintain energy levels throughout the day.  If you have not yet tried ketones, I really encourage you to give ketone IQ a try. You can get 10% off your order of ketone IQ by going to their website using the link in the show notes and entering the code BRADY10 at checkout. Again, use the link in the show notes to learn more about ketone IQ and when you order, enter BRADY10 at checkout for 10% off your order. Last but not least, if you enjoy my podcast, then you may also enjoy some of the writing that I publish on a weekly basis, which includes my weekly newsletter that I send out every Friday called Physiology Friday. If you'd like to check out my writing and subscribe to receive my weekly posts, please visit bradyholmer.substack.com. You can also find a link in the show notes.   Links Episode webpage: https://www.bradyholmer.com/pod/42  Watch on YouTube: https://www.youtube.com/watch?v=8h6O5jxu6Yk  Listen on Apple Podcasts: https://podcasts.apple.com/us/podcast/science-chill/id1494739189  Listen on Spotify: https://open.spotify.com/show/2ilq7P9OBAiqrxk4Ac4WQg  Brenner lab site: https://www.brennerlab.net/ Dr. Brenner's bio (Chromadex): https://www.chromadex.com/bios/charles-brenner/  Follow Dr. Brenner on Twitter: https://twitter.com/CharlesMBrenner  Support the podcast on Patreon: https://www.patreon.com/bradyholmer Other support options: https://www.bradyholmer.com/donate  Claim your FREE LMNT sample pack: https://DrinkLMNT.com/scienceandchill  10% off of H.V.M.N. Ketone IQ for the Science & Chill audience (use code BRADY10 at checkout): https://hvmn.com/products/ketone?rfsn=6449481.3c177c Subscribe to my Substack: https://bradyholmer.substack.com/about4:

Sponsored by ChromaDex. Mitochondrial dysfunction is linked to accelerated aging and illness. That's why supporting and enhancing mitochondrial function is a key clinical goal for many patients. In this interview integrative health expert Chris Meletis, ND, describes the research and clinical use of nicotinamide riboside to increase nicotinamide adenine dinucleotide (NAD+) to support mitochondrial function. Dosage, safety, and other clinical issues are also discussed. About the Expert Chris D. Meletis, ND, is an educator, international author and lecturer. His personal mission is “Changing America's Health One Person at a Time.” Meletis has authored 18 books and over 200 national scientific articles in journals including Natural Health, Alternative and Complementary Therapies, Townsend Letter for Doctors and Patients, Life Extension, Natural Pharmacy, and PubMed articles. Meletis served as dean of naturopathic medicine and chief medical officer for 7 years for the National College of Naturopathic Medicine (now the National University of Natural Medicine). He was awarded the 2003 Physician of the Year by the American Association of Naturopathic Physicians. He has a deep passion for helping the underprivileged and spearheaded the creation of 16 free natural medicine healthcare clinics in the Portland metropolitan area of Oregon. His website is www.DrMeletis.com. About the Sponsor Our Flagship Product TRU NIAGEN® Helping the World Age Better® Our team of scientists discovered that nicotinamide riboside (NR) could increase levels of NAD+, a vital function in cellular health that supports healthy aging. We then licensed patents for the nutritional and therapeutic uses of the breakthrough ingredient. Commercialized as Niagen®, it has been validated by extensive clinical research to be safe and effective at boosting NAD+ levels.  We deliver Niagen® as the sole active ingredient in our Healthcare Practitioner product Tru Niagen® Pro.

At Dartmouth College (2004) Dr. Brenner discovered nicotinamide riboside (NR) to be a vital precursor of nicotinamide adenine dinucleotide (NAD+). Dr Brenner explains the significance of NAD and why he believes supplementation with NR could help us “age better.” He also elaborates on why he refuses to describe NR as “miraculous or magic” and we talk about the ‘anti-aging' claims in the marketing of human longevity.NAD+ is fundamental to the creation of energy in every cell of your body.  NAD+ regulates pivotal cellular processes that are key to looking and feeling our best.In 2007 Dr. Brenner's lab discovered a second pathway by which NR is converted to NAD+ and showed that NR can extend the lifespan of yeast cells. Nicotinamide riboside (NR) is converted by the body into nicotinamide adenine dinucleotide (NAD) which is an essential molecule found in every living cell and plays a significant role in energy production, regulation of the circadian rhythm and cognitive function. It's received a lot of attention since its discovery (and Dr Brenner was responsible for the NAD+ pathway discovery)  with many claims to how it helps improve overall health and longevity. Dr. Charles Brenner is one of the world's leading authorities on the biochemistry behind NR and its potential to extend life in some organisms. Dr. Brenner was the Roy J. Carver Chair and Head of Biochemistry at the University of Iowa and founding co-director of the University of Iowa Obesity Initiative. He is also chief scientific adviser to Chromadex, a California-based company behind the NR supplement, Tru Niagen. Now, Charles Brenner is the Alfred E Mann Family Foundation Chair in Diabetes and Cancer Metabolism in the Department of Diabetes & Cancer Metabolism at the City of Hope, a National Cancer Institute-designated comprehensive cancer center and national leader in advancing research and treatment protocols. His laboratory focuses on disturbances in nicotinamide adenine dinucleotide (NAD), the central catalyst of metabolism, in diseases and conditions of metabolic stress.  He continues to research how the NAD system is dysregulated as a function of postpartum, coronavirus infection, inflammatory conditions, diabesity and specific malignancies with the dual goals of defining mechanisms of biological regulation and developing safe preventative and therapeutic interventions for people.Dr Charles: https://www.cityofhope.org/charles-brenner-labContact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwilliden

Roberta Stanhope, ARNP, PMH, CNS, BC, PLLC, who specializes in psychiatric evaluations and pharmacological management, joins Katherine Shagoury, to discuss the loneliness pandemic and ways to combat it through holistic pathways. She talks about issues of overdiagnosis and overprescribing in traditional clinical healthcare settings and holistic tools that can be used in place of, or alongside medicine. This episode is sponsored by Rupa Health and ChromaDex and brought to you in part by the Integrative Healthcare Symposium. Find us at integrativepractitioner.com or e-mail us at IPEditor@divcom.com. Theme music: “Upbeat Party” by Scott Holmes via freemusicarchive.org and “Carefree” by Kevin Mcleod via incompetech.com.

Benjamin Button in a bottle? ChromaDex CEO Rob Fried (CDXC) says he has a pill that can reverse aging, from the LD Micro Conference. Zillow (Z) finds that flipping houses in a bull market isn't as easy as it looked. How to raise prices on the sly: a lesson from Albertsons (ACI). Latham Group (SWIM) on the hunt for acquisition targets. The Drill Down with Cory Johnson offers a daily look at the business stories behind stocks on the move. Learn more about your ad choices. Visit megaphone.fm/adchoices

Raspberries, ellagic acid reveal benefits in two studies Oregon State University, October 1, 2021.    Articles that appeared recently in the Journal of Berry Research report that raspberries and compounds present in the fruit could help support healthy body mass and motor function, including balance, coordination and strength.   In one study, Neil Shay and colleagues at Oregon State University fed mice a high fat, high sugar diet plus one of the following: raspberry juice concentrate, raspberry puree concentrate, raspberry fruit powder, raspberry seed extract, ellagic acid (a polyphenol that occurs in a relatively high amount in raspberries), raspberry ketone, or a combination of raspberry ketone and ellagic acid. Additional groups of animals received a high fat, high sugar diet alone or a low fat diet.   While mice that received the high fat and sugar diet alone experienced a significant increase in body mass, the addition of raspberry juice concentrate, raspberry puree concentrate or ellagic acid plus raspberry ketone helped prevent this effect. Of note, mice that received raspberry juice concentrate experienced gains similar to those of animals given a low fat diet. "We hope that the findings from this study can help guide the design of future clinical trials," Dr Shay stated.   In another study, Barbara Shukitt-Hale, PhD, and her associates at Tufts University's Human Nutrition Research Center on Aging gave 19 month old rats a control diet or a diet enhanced with raspberry extract for 11 weeks. Psychomotor behavior was assessed during week 7 and cognitive testing was conducted during weeks 9-10.   Animals that received raspberry performed better on psychomotor coordination and balance, and had better muscle tone, strength and stamina than those that received a control diet. "These results may have important implications for healthy aging," stated Dr Shukitt-Hale. "While further research in humans is necessary, animal model studies are helpful in identifying deficits associated with normal aging."       Massage doesn't just make muscles feel better, it makes them heal faster and stronger Harvard University, October 6, 2021 Massage has been used to treat sore, injured muscles for more than 3,000 years, and today many athletes swear by massage guns to rehabilitate their bodies. But other than making people feel good, do these "mechanotherapies" actually improve healing after severe injury? According to a new study from researchers at Harvard's Wyss Institute for Biologically Inspired Engineering and John A. Paulson School of Engineering and Applied Sciences (SEAS), the answer is "yes." Using a custom-designed robotic system to deliver consistent and tunable compressive forces to mice's leg muscles, the team found that this mechanical loading (ML) rapidly clears immune cells called neutrophils out of severely injured muscle tissue. This process also removed inflammatory cytokinesreleased by neutrophils from the muscles, enhancing the process of muscle fiber regeneration. The research is published in Science Translational Medicine. "Lots of people have been trying to study the beneficial effects of massage and other mechanotherapies on the body, but up to this point it hadn't been done in a systematic, reproducible way. Our work shows a very clear connection between mechanical stimulation and immune function. This has promise for regenerating a wide variety of tissues including bone, tendon, hair, and skin, and can also be used in patients with diseases that prevent the use of drug-based interventions," said first author Bo Ri Seo, Ph.D., who is a Postdoctoral Fellow in the lab of Core Faculty member Dave Mooney, Ph.D. at the Wyss Institute and SEAS. Seo and her coauthors started exploring the effects of mechanotherapy on injured tissues in mice several years ago, and found that it doubled the rate of muscle regeneration and reduced tissue scarring over the course of two weeks. Excited by the idea that mechanical stimulation alone can foster regeneration and enhance muscle function, the team decided to probe more deeply into exactly how that process worked in the body, and to figure out what parameters would maximize healing. They teamed up with soft robotics experts in the Harvard Biodesign Lab, led by Wyss Associate Faculty member Conor Walsh, Ph.D., to create a small device that used sensors and actuators to monitor and control the force applied to the limb of a mouse. " The device we created allows us to precisely control parameters like the amount and frequency of force applied, enabling a much more systematic approach to understanding tissue healing than would be possible with a manual approach," said co-second author Christopher Payne, Ph.D., a former Postdoctoral Fellow at the Wyss Institute and the Harvard Biodesign Lab who is now a Robotics Engineer at Viam, Inc.  Once the device was ready, the team experimented with applying force to mice's leg muscles via a soft silicone tip and used ultrasound to get a look at what happened to the tissue in response. They observed that the muscles experienced a strain of between 10-40%, confirming that the tissues were experiencing mechanical force. They also used those ultrasound imaging data to develop and validate a computational model that could predict the amount of tissue strain under different loading forces. They then applied consistent, repeated force to injured muscles for 14 days. While both treated and untreated muscles displayed a reduction in the amount of damaged muscle fibers, the reduction was more pronounced and the cross-sectional area of the fibers was larger in the treated muscle, indicating that treatment had led to greater repair and strength recovery. The greater the force applied during treatment, the stronger the injured muscles became, confirming that mechanotherapy improves muscle recovery after injury. But how? Evicting neutrophils to enhance regeneration To answer that question, the scientists performed a detailed biological assessment, analyzing a wide range of inflammation-related factors called cytokines and chemokines in untreated vs. treated muscles. A subset of cytokines was dramatically lower in treated muscles after three days of mechanotherapy, and these cytokines are associated with the movement of immune cells called neutrophils, which play many roles in the inflammation process. Treated muscles also had fewer neutrophils in their tissue than untreated muscles, suggesting that the reduction in cytokines that attract them had caused the decrease in neutrophil infiltration. The team had a hunch that the force applied to the muscle by the mechanotherapy effectively squeezed the neutrophils and cytokines out of the injured tissue. They confirmed this theory by injecting fluorescent molecules into the muscles and observing that the movement of the molecules was more significant with force application, supporting the idea that it helped to flush out the muscle tissue. To pick apart what effect the neutrophils and their associated cytokines have on regenerating muscle fibers, the scientists performed in vitro studies in which they grew muscle progenitor cells (MPCs) in a medium in which neutrophils had previously been grown. They found that the number of MPCs increased, but the rate at which they differentiated (developed into other cell types) decreased, suggesting that neutrophil-secreted factors stimulate the growth of muscle cells, but the prolonged presence of those factors impairs the production of new muscle fibers. "Neutrophils are known to kill and clear out pathogens and damaged tissue, but in this study we identified their direct impacts on muscle progenitor cell behaviors," said co-second author Stephanie McNamara, a former Post-Graduate Fellow at the Wyss Institute who is now an M.D.-Ph.D. student at Harvard Medical School (HMS). "While the inflammatory response is important for regeneration in the initial stages of healing, it is equally important that inflammation is quickly resolved to enable the regenerative processes to run its full course." Seo and her colleagues then turned back to their in vivo model and analyzed the types of muscle fibers in the treated vs. untreated mice 14 days after injury. They found that type IIX fibers were prevalent in healthy muscle and treated muscle, but untreated injured muscle contained smaller numbers of type IIX fibers and increased numbers of type IIA fibers. This difference explained the enlarged fiber size and greater force production of treated muscles, as IIX fibers produce more force than IIA fibers. Finally, the team homed in on the optimal amount of time for neutrophil presence in injured muscle by depleting neutrophils in the mice on the third day after injury. The treated mice's muscles showed larger fiber size and greater strength recovery than those in untreated mice, confirming that while neutrophils are necessary in the earliest stages of injury recovery, getting them out of the injury site early leads to improved muscle regeneration. "These findings are remarkable because they indicate that we can influence the function of the body's immune system in a drug-free, non-invasive way," said Walsh, who is also the Paul A. Maeder Professor of Engineering and Applied Science at SEAS and whose group is experienced in developing wearable technology for diagnosing and treating disease. "This provides great motivation for the development of external, mechanical interventions to help accelerate and improve muscle and tissue healing that have the potential to be rapidly translated to the clinic." The team is continuing to investigate this line of research with multiple projects in the lab. They plan to validate this mechanotherpeutic approach in larger animals, with the goal of being able to test its efficacy on humans. They also hope to test it on different types of injuries, age-related muscle loss, and muscle performance enhancement. "The fields of mechanotherapy and immunotherapy rarely interact with each other, but this work is a testament to how crucial it is to consider both physical and biological elements when studying and working to improve human health," said Mooney, who is the corresponding author of the paper and the Robert P. Pinkas Family Professor of Bioengineering at SEAS. "The idea that mechanics influence cell and tissue function was ridiculed until the last few decades, and while scientists have made great strides in establishing acceptance of this fact, we still know very little about how that process actually works at the organ level. This research has revealed a previously unknown type of interplay between mechanobiology and immunology that is critical for muscle tissue healing, in addition to describing a new form of mechanotherapy that potentially could be as potent as chemical or gene therapies, but much simpler and less invasive," said Wyss Founding Director Don Ingber, M.D., Ph.D., who is also the Judah Folkman Professor of Vascular Biology at (HMS) and the Vascular Biology Program at Boston Children's Hospital, as well as Professor of Bioengineering at SEAS.   Vitamin E could help protect older men from pneumonia University of Helsinki (Finland), October 7 2021.    An article that appeared in Clinical Interventions in Aging reported a protective role for vitamin E against pneumonia in older men.   For the current investigation, Dr Harri Hemilä of the University of Helsinki, Finland analyzed data from the Alpha-Tocopherol Beta-Carotene (ATBC) Cancer Prevention Study conducted in Finland. The trial included 29,133 men between the ages of 50 to 69 years who smoked at least five cigarettes daily upon enrollment. Participants received alpha tocopherol (vitamin E), beta carotene, both supplements, or a placebo for five to eight years.   The current study was limited to 7,469 ATBC participants who started smoking at age 21 or older. Among this group, supplementation with vitamin E was associated with a 35% lower risk of developing pneumonia in comparison with those who did not receive the vitamin.  Light smokers who engaged in leisure time exercise had a 69% lower risk compared with unsupplemented members of this subgroup. The risk in this subgroup of developing pneumonia by age 74 was 12.9%.   Among the one-third of the current study's population who quit smoking for a median period of two years, there was a 72% lower risk of pneumonia in association with vitamin E supplementation. In this group, exercisers who received vitamin E experienced an 81% lower pneumonia risk.   Dr Hemilä observed that the benefit for vitamin E in this study was strongest for older subjects—a group at higher risk of pneumonia.   "The current analysis of individual-level data suggests that trials on vitamin E and pneumonia on nonsmoking elderly males are warranted," he concluded.       Toxic fatty acids to blame for brain cell death after injury New York University, October 7, 2021 Cells that normally nourish healthy brain cells called neurons release toxic fatty acids after neurons are damaged, a new study in rodents shows. This phenomenon is likely the driving factor behind most, if not all, diseases that affect brain function, as well as the natural breakdown of brain cells seen in aging, researchers say. Previous research has pointed to astrocytes—a star-shaped glial cell of the central nervous system—as the culprits behind cell death seen in Parkinson's disease and dementia, among other neurodegenerative diseases. While many experts believed that these cells released a neuron-killing molecule to "clear away" damaged brain cells, the identity of this toxin has until now remained a mystery. Led by researchers at NYU Grossman School of Medicine, the new investigation provides what they say is the first evidence that tissue damage prompts astrocytes to produce two kinds of fats, long-chain saturated free fatty acids and phosphatidylcholines. These fats then trigger cell death in damaged neurons, the electrically active cells that send messages throughout nerve tissue. Publishing Oct. 6 in the journal Nature, the study also showed that when researchers blocked fatty acid formation in mice, 75 percent of neurons survived compared with 10 percent when the fatty acids were allowed to form. The researchers' earlier work showed that brain cells continued to function when shielded from astrocyte attacks.  "Our findings show that the toxic fatty acids produced by astrocytes play a critical role in brain cell death and provide a promising new target for treating, and perhaps even preventing, many neurodegenerative diseases," says study co-senior author Shane Liddelow, Ph.D. Liddelow, an assistant professor in the Department of Neuroscience and Physiology at NYU Langone Health, adds that targeting these fats instead of the cells that produce them may be a safer approach to treating neurodegenerative diseasesbecause astrocytes feed nerve cells and clear away their waste. Stopping them from working altogether could interfere with healthy brain function. Although it remains unclear why astrocytes produce these toxins, it is possible they evolved to destroy damaged cells before they can harm their neighbors, says Liddelow. He notes that while healthy cells are not harmed by the toxins, neurons become susceptible to the damaging effects when they are injured, mutated, or infected by prions, the contagious, misfolded proteins that play a major role in mad cow disease and similar illnesses. Perhaps in chronic diseases like dementia, this otherwise helpful process goes off track and becomes a problem, the study authors say. For the investigation, researchers analyzed the molecules released by astrocytes collected from rodents. They also genetically engineered some groups of mice to prevent the normal production of the toxic fats and looked to see whether neuron death occurred after an acute injury. "Our results provide what is likely the most detailed molecular map to date of how tissue damage leads to brain cell death, enabling researchers to better understand why neurons die in all kinds of diseases," says Liddelow, also an assistant professor in the Department of Ophthalmology at NYU Langone. Liddelow cautions that while the findings are promising, the genetic techniques used to block the enzyme that produces toxic fatty acids in mice are not ready for use in humans. As a result, the researchers next plan is to explore safe and effective ways to interfere with the release of the toxins in human patients. Liddelow and his colleagues had previously shown these neurotoxic astrocytes in the brains of patients with Parkinson's, Huntington's disease, and multiple sclerosis, among other diseases.   Clinical trial for nicotinamide riboside: Vitamin safely boosts levels of important cell metabolite linked to multiple health benefits University of Iowa Health Care, October 3, 2021   In the first controlled clinical trial of nicotinamide riboside (NR), a newly discovered form of Vitamin B3, researchers have shown that the compound is safe for humans and increases levels of a cell metabolite that is critical for cellular energy production and protection against stress and DNA damage.   Studies in mice have shown that boosting the levels of this cell metabolite -- known as NAD+ -- can produce multiple health benefits, including resistance to weight gain, improved control of blood sugar and cholesterol, reduced nerve damage, and longer lifespan. Levels of NAD+ diminish with age, and it has been suggested that loss of this metabolite may play a role in age-related health decline.   These findings in animal studies have spurred people to take commercially available NR supplements designed to boost NAD+. However, these over-the-counter supplements have not undergone clinical trials to see if they work in people.   The new research, reported in the journal Nature Communications, was led by Charles Brenner, PhD, professor and Roy J. Carver Chair of Biochemistry at the University of Iowa Carver College of Medicine in collaboration with colleagues at Queens University Belfast and ChromaDex Corp. (NASDAQ: CDXC), which supplied the NR used in the trial. Brenner is a consultant for ChromaDex. He also is co-founder and Chief Scientific Adviser of ProHealthspan, which sells NR supplements under the trade name Tru NIAGEN®.   The human trial involved six men and six women, all healthy. Each participant received single oral doses of 100 mg, 300 mg, or 1,000 mg of NR in a different sequence with a seven-day gap between doses. After each dose, blood and urine samples were collected and analyzed by Brenner's lab to measure various NAD+ metabolites in a process called metabolomics. The trial showed that the NR vitamin increased NAD+ metabolism by amounts directly related to the dose, and there were no serious side effects with any of the doses.   "This trial shows that oral NR safely boosts human NAD+ metabolism," Brenner says. "We are excited because everything we are learning from animal systems indicates that the effectiveness of NR depends on preserving and/or boosting NAD+ and related compounds in the face of metabolic stresses. Because the levels of supplementation in mice that produce beneficial effects are achievable in people, it appears than health benefits of NR will be translatable to humans safely."   The next step will be to study the effect of longer duration NR supplementation on NAD+ metabolism in healthy adults, but Brenner also has plans to test the effects of NR in people with diseases and health conditions, including elevated cholesterol, obesity and diabetes, and people at risk for chemotherapeutic peripheral neuropathy.   Prior to the formal clinical trial, Brenner conducted a pilot human study -- on himself. In 2004, he had discovered that NR is a natural product found in milk and that there is pathway to convert NR to NAD+ in people. More than a decade of research on NR metabolic pathways and health effects in mice and rats had convinced him that NR supplementation had real promise to improve human health and wellness. After consulting with UI's institutional review board, he conducted an experiment in which he took 1 gram of NR once a day for seven days, and his team analyzed blood and urine samples using mass spectrometry. The experiment showed that Brenner's blood NAD+ increased by about 2.7 times. In addition, though he reported immediate sensitivity to flushing with the related compound niacin, he did not experience any side effects taking NR.   The biggest surprise from his metabolomic analysis was an increase in a metabolite called NAAD, which was multiplied by 45 times, from trace levels to amounts in the micromolar range that were easily detectable.   "While this was unexpected, I thought it might be useful," Brenner says. "NAD+ is an abundant metabolite and it is sometimes hard to see the needle move on levels of abundant metabolites. But when you can look at a low-abundance metabolite that goes from undetectable to easily detectable, there is a great signal to noise ratio, meaning that NAAD levels could be a useful biomarker for tracking increases in NAD+ in human trials."   Brenner notes this was a case of bidirectional translational science; having learned something from the initial human experiment, his team was able to return to laboratory mice to explore the unexpected NAAD finding in more detail.   Brenner's mouse study showed that NAAD is formed from NR and confirmed that NAAD levels are a strong biomarker for increased NAD+ metabolism. The experiments also revealed more detail about NAD+ metabolic pathways.   In particular, the researchers compared the ability of all three NAD+ precursor vitamins -- NR, niacin, and nicotinamide -- to boost NAD+ metabolism and stimulate the activity of certain enzymes, which have been linked to longevity and healthbenefits. The study showed for the first time that oral NR is superior to nicotinamide, which is better than niacin in terms of the total amount of NAD+ produced at an equivalent dose. NR was also the best of the three in stimulating the activity of sirtuin enzymes. However, in this case, NR was the best at stimulating sirtuin-like activities, followed by niacin, followed by nicotinamide.   The information from the mouse study subsequently helped Brenner's team design the formal clinical trial. In addition to showing that NR boosts NAD+ in humans without adverse effects, the trial confirmed that NAAD is a highly sensitive biomarker of NAD+ supplementation in people.   "Now that we have demonstrated safety in this small clinical trial, we are in a position to find out if the health benefits that we have seen in animals can be reproduced in people," says Brenner, who also is co-director of the Obesity Research and Education Initiative, professor of internal medicine, and a member of the Fraternal Order of Eagles Diabetes Research Center at the UI.   Protecting the ozone layer is delivering vast health benefits Montreal Protocol will spare Americans from 443 million skin cancer cases National Center for Atmospheric Research, October 7, 2021 An international agreement to protect the ozone layer is expected to prevent 443 million cases of skin cancer and 63 million cataract cases for people born in the United States through the end of this century, according to new research. The research team, by scientists at the National Center for Atmospheric Research (NCAR), ICF Consulting, and U.S. Environmental Protection Agency (EPA), focused on the far-reaching impacts of a landmark 1987 treaty known as the Montreal Protocol and later amendments that substantially strengthened it. The agreement phased out the use of chemicals such as chlorofluorocarbons (CFCs) that destroy ozone in the stratosphere. Stratospheric ozone shields the planet from harmful levels of the Sun's ultraviolet (UV) radiation, protecting life on Earth. To measure the long-term effects of the Montreal Protocol, the scientists developed a computer modeling approach that enabled them to look to both the past and the future by simulating the treaty's impact on Americans born between 1890 and 2100. The modeling revealed the treaty's effect on stratospheric ozone, the associated reductions in ultraviolet radiation, and the resulting health benefits.  In addition to the number of skin cancer and cataract cases that were avoided, the study also showed that the treaty, as most recently amended, will prevent approximately 2.3 million skin cancer deaths in the U.S. “It's very encouraging,” said NCAR scientist Julia Lee-Taylor, a co-author of the study. “It shows that, given the will, the nations of the world can come together to solve global environmental problems.” The study, funded by the EPA, was published in ACS Earth and Space Chemistry. NCAR is sponsored by the National Science Foundation. Mounting concerns over the ozone layer Scientists in the 1970s began highlighting the threat to the ozone layer when they found that CFCs, used as refrigerants and in other applications, release chlorine atoms in the stratosphere that set off chemical reactions that destroy ozone. Concerns mounted the following decade with the discovery of an Antarctic ozone hole. The loss of stratospheric ozone would be catastrophic, as high levels of UV radiation have been linked to certain types of skin cancer, cataracts, and immunological disorders. The ozone layer also protects terrestrial and aquatic ecosystems, as well as agriculture. Policy makers responded to the threat with the 1987 Montreal Protocol on Substances that Deplete the Ozone Layer, in which nations agreed to curtail the use of certain ozone-destroying substances. Subsequent amendments strengthened the treaty by expanding the list of ozone-destroying substances (such as halons and hydrochlorofluorocarbons, or HCFCs) and accelerating the timeline for phasing out their use. The amendments were based on Input from the scientific community, including a number of NCAR scientists, that were summarized in quadrennial Ozone Assessment reports. To quantify the impacts of the treaty, the research team built a model known as the Atmospheric and Health Effects Framework. This model, which draws on various data sources about ozone, public health, and population demographics, consists of five computational steps. These simulate past and future emissions of ozone-destroying substances, the impacts of those substances on stratospheric ozone, the resulting changes in ground-level UV radiation, the U.S. population's exposure to UV radiation, and the incidence and mortality of health effects resulting from the exposure. The results showed UV radiation levels returning to 1980 levels by the mid-2040s under the amended treaty. In contrast, UV levels would have continued to increase throughout this century if the treaty had not been amended, and they would have soared far higher without any treaty at all.  Even with the amendments, the simulations show excess cases of cataracts and various types of skin cancer beginning to occur with the onset of ozone depletion and peaking decades later as the population exposed to the highest UV levels ages. Those born between 1900 and 2040 experience heightened cases of skin cancer and cataracts, with the worst health outcomes affecting those born between about 1950 and 2000. However, the health impacts would have been far more severe without the treaty, with cases of skin cancer and cataracts rising at an increasingly rapid rate through the century.  “We peeled away from disaster,” Lee-Taylor said. “What is eye popping is what would have happened by the end of this century if not for the Montreal Protocol. By 2080, the amount of UV has tripled. After that, our calculations for the health impacts start to break down because we're getting so far into conditions that have never been seen before.” The research team also found that more than half the treaty's health benefits could be traced to the later amendments rather than the original 1987 Montreal Protocol. Overall, the treaty prevented more than 99% of potential health impacts that would have otherwise occurred from ozone destruction. This showed the importance of the treaty's flexibility in adjusting to evolving scientific knowledge, the authors said. The researchers focused on the U.S. because of ready access to health data and population projections. Lee-Taylor said that the specific health outcomes in other countries may vary, but the overall trends would be similar. “The treaty had broad global benefits,” she said.     What is Boron? The trace mineral boron provides profound anti-cancer effects, in addition to maintaining stronger bones. Life Extension, September 2021 Boron is a trace mineral found in the earth's crust and in water. Its importance in human health has been underestimated. Boron has been shown to have actions against specific types of malignancies, such as: Cervical cancer: The country Turkey has an extremely low incidence of cervical cancer, and scientists partially attribute this to its boron-rich soil.1 When comparing women who live in boron-rich regions versus boron-poor regions of Turkey, not a single woman living in the boron-rich regions had any indication of cervical cancer.2(The mean dietary intake of boron for women in this group was 8.41 mg/day.)  Boron interferes with the life cycle of the human papillomavirus (HPV), which is a contributing factor in approximately 95% of all cervical cancers.1  Considering that HPV viruses are increasingly implicated in head and neck cancers,3,4 supplementation with this ultra-low-cost mineral could have significant benefits in protecting against this malignancy that is increasing in prevalence. Lung cancer: A study conducted at the University of Texas MD Anderson Cancer Center between 1995 and 2005 found that increased boron intake was associated with a lower risk of lung cancer in postmenopausal women who were taking hormone replacement therapy. Prostate cancer: Studies point to boron's ability to inhibit the growth and spread of prostate cancer cells.  In one study, when mice were exposed to boric acid, their tumors shrank by as much as 38%.6 One analysis found that increased dietary boron intake was associated with a decreased risk of prostate cancer.7 Several human and animal studies have confirmed the important connection between boron and bone health. Boron prevents calcium loss,8 while also alleviating the bone problems associated with magnesium and vitamin D deficiency.9 All of these nutrients help maintain bone density. A study in female rats revealed the harmful effects a deficiency in boron has on bones, including:10 Decreased bone volume fraction, a measure of bone strength, Decreased thickness of the bone's spongy inner layer, and Decreased maximum force needed to break the femur. And in a study of post-menopausal women, supplementation with3 mg of boron per day prevented calcium loss and bone demineralization by reducing urinary excretion of both calcium and magnesium.8 In addition to its bone and anti-cancer benefits, there are nine additional reasons boron is an important trace mineral vital for health and longevity. It has been shown to:1 Greatly improve wound healing, Beneficially impact the body's use of estrogen, testosterone, and vitamin D, Boost magnesium absorption, Reduce levels of inflammatory biomarkers, such as high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor α (TNF-α), Raise levels of antioxidant enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase, Protect against pesticide-induced oxidative stress and heavy-metal toxicity, Improve the brain's electrical activity, which may explain its benefits for cognitive performance, and short-term memory in the elderly, Influence the formation and activity of key biomolecules, such as S-adenosyl methionine (SAM-e) and nicotinamide adenine dinucleotide (NAD+), and Potentially help ameliorate the adverse effects of traditional chemotherapeutic agents. Because the amount of boron varies in the soil, based on geographical location, obtaining enough boron through diet alone can be difficult. Supplementing with low-cost boron is an effective way to maintain adequate levels of this overlooked micronutrient.

This week, Liz is joined by Film Producer and CEO of Health and Wellness company ChromaDex, Rob Fried. Rob explains how he broke into the entertainment industry and the knowledge he developed along the way which has guided him to pivot and excel in bioscience. Rob shares what drove his passion to chase his many different dreams and the key takeaways from working in multiple different industries. Follow Liz on Twitter: @LizClaman

Dr. Charles Brenner Ph.D. is the Alfred E Mann Family Foundation Chair in Diabetes and Cancer Metabolism, and Professor and Chair of the Department of Diabetes & Cancer Metabolism, at the City of Hope Comprehensive Cancer Center (https://www.cityofhope.org/faculty/ch...). With his Ph.D. in Cancer Biology from Stanford University, Dr. Brenner's laboratory focuses on disturbances in nicotinamide adenine dinucleotide (NAD), the central catalyst of metabolism, in diseases and conditions of metabolic stress (https://www.cityofhope.org/charles-br...). Among his most significant discoveries, Dr. Brenner identified nicotinamide riboside (NR) as a vitamin precursor of NAD, as well as a quantitative metabolomic technology that allowed him to discover that the NAD system is disturbed by many diseases and conditions of metabolic stress, including diabetes and cancer. Specifically, Dr. Brenner and colleagues have found that in animal models of fatty liver, type 2 diabetes, diabetic and chemotherapeutic neuropathy, central brain injury, heart failure, postpartum and coronavirus infection, the NAD system is disturbed and that in these models, provision of nicotinamide riboside is highly protective. Dr. Brenner also led the team that conducted the first clinical trial of nicotinamide riboside establishing safe oral availability and has participated in trials establishing safety and potential activities of nicotinamide riboside in clearance of liver fat and depression of common markers of inflammation. Dr. Brenner continues to research how the NAD system is disregulated as a function of postpartum, coronavirus infection, inflammatory conditions, diabesity and specific malignancies, with the dual goals of defining mechanisms of biological regulation and developing safe preventative and therapeutic interventions for people. Dr. Brenner's work over the years been funded by numerous agencies including the Leukemia & Lymphoma Society, the March of Dimes, the Burroughs Wellcome Fund, the Beckman Foundation, the Lung Cancer Research Foundation, the National Institutes of Health, and the National Science Foundation. Dr. Brenner is author of more than 140 publications and was the senior editor of the 2004 book, Oncogenomics: Molecular Approaches to Cancer. Dr. Brenner also serves as a Member of the scientific advisory board and Chief Scientific Advisor to ChromaDex, a global bioscience company dedicated to healthy aging.

ChromaDex (CDXC) provides research and quality-control products and services to the natural products industry. Its consumer product segment offers TRU NIAGEN to consumers worldwide. The company's CEO, Robert Fried, discusses new partnership with Walmart (WMT) retail stores across the U.S. The stock is up more than 80% in 2021 and hit an all-time high on February 25th.

Inside Value analist Robbe Delaet interviewt de CEO van Chromadex. Chromadex (ticker: CDXC) is een Amerikaanse small cap die zich specialiseert in voedingssupplementen en nog zeer ongekend is op de beurs. Momenteel kan Chromadex worden omschreven als e-commerce biotech bedrijf. Het gros van zijn omzet wordt gegenereerd uit de verkoop van TRU NIAGEN als supplement (online of via partners). Op basis van onderzoeksresultaten mag TRU NIAGEN van de toezichthouders in de Verenigde Staten vandaag reeds worden gepromoot als supplement voor “healthy ageing”: het verhogen van de levenswaarde tijdens het ouders worden. Momenteel zijn er tientallen menselijke studies aan de gang om de wetenschappelijke data van TUR NIAGEN op te schalen. Op basis hiervan zou Chromadex in de toekomst de status “healthy ageing” kunnen ombuigen naar “antiageing”. TRU NIAGEN bestellen kan via https://bit.ly/3gUqty2 0:00 Intro 1:50 Successful career of Rob Fried 7:00 The science behind anti-aging pil Tru Niagen 26:40 Chromadex' financials 28:35 Chromadex' patents 36:30 Future potential of Chromadex 46:00 Biggest investor: Li Ka Shing 50:50 Outro Download een gratis aandelentip op https://bit.ly/3n3cN4z Volg al onze blogs/video's/podcasts op de voet via Telegram: https://bit.ly/3layYEh Contact: info@valuejagers.com ******************************************** Disclaimer: Let wel op. De inhoud van deze video mag niet beschouwd worden als beleggingsadvies of het aanzetten tot het kopen/verkopen van een effect. Doe altijd zelf je huiswerk. Met aandelen kunnen zware verliezen geboekt worden als u niet weet wat u doet.

The CEO of Chromadex (CDXC), Robert Fried, says that the dietary supplement and food ingredient company's Tru Niagen product will be available in 3K Walmart stores across the U.S. in June 2021. Its recent earnings report revealed -$0.10 in EPS and $15.4M in revenue.

Chromadex Corp - CDXC Stock - Stock Analysis. Chromadex Corporation has entered into an agreement with an international investor to grow its dietary supplement business. This company has a supplement that is good for cellular health and aging. This could be an awesome addition to your portfolio from what looks like a really innovative company in the Drug Biomedical Industry!Try VectorVest Risk-Free for 30 Days ➥➥➥ https://www.vectorvest.com/YTVectorVest mobile app ➥➥➥ http://bit.ly/2UjF6y6 

ChromaDex leverages its complementary business units to discover, acquire, develop and commercialize patented and proprietary ingredient technologies that address the dietary supplement, food, beverage, skincare and pharmaceutical markets. CEO Rob Fried joins Mark Alyn for a discussion on supplements and the film industry.

ChromaDex leverages its complementary business units to discover, acquire, develop and commercialize patented and proprietary ingredient technologies that address the dietary supplement, food, beverage, skincare and pharmaceutical markets. CEO Rob Fried joins Mark Alyn for a discussion on supplements and the film industry.

This week's guest is Dr. Alyssa Dweck, a practicing gynecologist and ChromaDex spokesperson in Westchester County, New York and Assistant Clinical Professor in the Department of Obstetrics, Gynecology, and Reproductive Science at the Mount Sinai School of Medicine. In this episode, Dr, Dweck will discuss women's health, sex drives and how to manage period pain. As an author of three books and an accomplished triathlete, Dr. Dweck offers her expertise across various platforms in an effort to destigmatize gynecologic issues and support women’s health across North America. This episode will feature some tips that you might not have known, but will surely want to use! Visit Dr. Dweck's website for more information at: dr.dweck.com

One of the minds behind movies Rudy and Godzilla! CEO ChromaDex, and Academy Award winning Producer Robert Fried, is interviewed by David Cogan founder of Eliances and host of the Eliances Heroes show broadcast on am and fm network channels, internet radio, and online syndication.

One of the minds behind movies Rudy and Godzilla! CEO ChromaDex, and Academy Award winning Producer Robert Fried, is interviewed by David Cogan founder of Eliances and host of the Eliances Heroes show broadcast on am and fm network channels, internet radio, and online syndication.

In this twenty-first episode, Nichola Conlon provides a scientific background, introducing sirtuins and NAD. She then explains why popular NAD+ boosters, NR and NMN, are first-gen products. Read the transcript She details how Nuchido formulated the first second-gen product by taking a novel whole systems approach. Lots of NAD, anti-aging, and nutraceutical discussion along the way. Topics we discussed in this episode Recent personal experience with COVID-19 Her molecular biology PhD focus Systems pharmacology Help from Aubrey de Gray Disillusioned with drug development Founding Nuchido What are Sirtuins? What is NAD? Importance of NAD. Why Boost NAD Levels? Inefficiency of First-Gen NAD Supplements: NR and NMN Three ingredients to boost NAD Pure NAD limitations Nicotinamide Riboside (NR) Nicotinamide Mononucleotide (NMN) 60% increase in NAD "only" Second-gen, demonstrated it can be done much better if you take a whole systems approach Importance of NAD salvage pathway PARP enzymes Inability to power sustained high-levels because of salvage pathway deterioration First-gen may not be great for epigenetics Increases expression of the enzymes in the salvage pathway that are known to decline with age Ingredients that reduce the expression of other processes that are actually wasting NAD Enzyme called CD38 Inflammatory levels - CD38 just chews up NAD Multiple things that you can do to fix the cell before you even need to put precursors in. NAD decreases with age Do we Need NAD Supplements? Sirtuins and mitochondrial biogenesis Boosting your NAD levels, improves mitochondrial function. Multiple reasons that are causing the NAD to decline, boosting as with first-gen only the amount of raw material that your cell has is quite naïve Second-gen helps fixe your body's natural ability to make and recycle its own NAD Nuchido TIME+ boosts NAD on average by 242%, four times more than the 60% widely cited for first-gen ChromaDex vs Elyisum Health Terms B3, niacin, nicotinamide, nicotinic acid, NR Abram Hoffer and orthomolecular medicine Nicotinamide is not likely to be a sirtuin inhibitor, How to measure NAD levels Nuchido TIME+ ingredients Alpha lipoic acid (ALA) and effects on AMPK Conversion of NADH to NAD+ Drift more towards having more NADH in your cell with age Pathway called NQO1, converts NADH back to NAD+ ALA is a really powerful antioxidant, activates NRF2 ALA vs ALA-R Sophora Japonica Extract Rutin, senolytic NAMP Aging is an inflicted cascade disorder Show links Nuchido (Company Website) ChromaDex (Company Website) Elysium Health (Company Website) Elysium Health, Inc. Loses Appeal of Patent Challenge Decision (Press Release) Orthomolecular Medicine (Wikipedia Entry) Abram Hoffer (Wikipedia Entry) Niacin: The Real Story: Learn about the Wonderful Healing Properties of Niacin (Amazon, Book) Orthomolecular Medicine for Everyone (Amazon, Book) GlycanAge (Company Website)

Today on the Big Biz Show Rob Fried from ChromaDex joins us to talk about the Tru Niagen and the effects of NAD on the body. Following Geoff Selzer from Resonate Blends (koan.life) joins us to talk about the more recent legalizations of cannabis following the 2020 election. Lastly, Tom Del Beccaro joins us to discuss the latest results of the presidential election.

Mottek On Money Special Edition covering Wall Street and Main Street during the coronavirus crisis: The latest stock market rally fizzles out as hopes fade on another economic rescue deal in Washington. Stocks moved higher at the opening bell on the latest reading on China's economy show it grew nearly 5 percent in the last quarter. But the ongoing stimulus drama, rising coronavirus case numbers in the U.S. and Europe, along with comments for the Fed's vice chair on the pace of the recovery sent stocks tumbling. The Dow came in for a closing loss of 411 points. Analysis on the markets and the economy from Art Hogan, Chief Market Strategist, National Securities.  A Los Angeles celebrity dentist previously honored as a KNX Hero for his work with the homeless achieves another milestone. Dr. Jay S. Grossman, Founder and CEO, of the non profit group Homeless Not Toothless, celebrates its 10,000th day of helping homeless veterans. Rob Fried, an Academy Award winner, former top Hollywood studio executive, discusses heading up a Los Angeles based biosciences company ChromaDex and its flagship anti aging product, the outlook for a coronavirus vaccine and how Hollywood production has been impacted by the pandemic.  Support the show: https://www.frankmottek.com See omnystudio.com/listener for privacy information.

Today’s Big Biz features Rob Fried from ChromaDex discussing his product Tru Niagen. Following, Darren Jamison from Capstone Turbine Corporation explains the #ShiftToGreen potential, and their involvement in the Indy500 racing. Lastly, Sam Ataya from Western Magnesium joined Russ and Sully to discuss 2021 prospects.

Ben Franklin is quoted as saying, “An ounce of prevention is worth a pound of cure.” And, in the middle of the COVID-19 pandemic, we're all wondering if there's anything we can do to help protect ourselves. New preclinical research may hold the answer to just that.    Lead researcher of the study, Chair of Biochemistry at the University of Iowa and ChromaDex Chief Scientific Advisor, Dr. Charles Brenner joins us now to break it all down for us.

Rob Fried was the former head of production at Columbia Pictures who switched gears and is now the CEO of Chromadex, an integrated nutraceutical company devoted to improving the way people age. In today’s episode, he talks about his back and forth successes in the film industry, but how his passion for the research behind anti-aging kept pulling at him. Fried’s diverse experiences in different fields make this episode super insightful and unique. He educates us on some of the latest research in anti-aging while integrating tidbits about his path to success as a film producer, screenwriter, studio executive.Youtube Link to This EpisodeChromadex

Rob Fried is the CEO of Chromadex which makes TRU NIAGEN. And when you hear why he's so excited for this game-changing product - it'll all make sense.  SERIOUSLY - YOU SHOULD CHECK IT OUT - LINK HERE I've been taking it for just over a month and here are the benefits I've noticed.  • More muscle mass • Increased energy, especially in the evening time • Motivated to get work done so I can enjoy the day • Stronger drive to to play with my kids The science is strong, the results are consistent and the formula is proven effective - so I'm excited to be releasing this conversation to you.  Here's the boiled down science. Nicotinamide Riboside (NR) when consumed, converts to NAD in the body. NAD is required for ATP production (energy).  Between the ages of 20 and 40, our NAD levels decrease by 50%, and another 50% from 40-60. Without sufficient NAD levels we simply cannot function at a high level of energy. When you supplement with NR, your body converts it, uses it, and makes you more efficient and more resilient at the cellular level.  Fascinating shit.  In this episode we cover: • Why taking NAD orally is not efficient • Why IV NAD protocols are not optimal • How and why our NAD levels decrease over time • The scientific support of TRU NIAGEN • Why other companies offering NAD supplements are inferior Enjoy!     

Bo and I discuss some of the leading candidates for extending both human lifespan and “health-span”, including metformin, nicotinamide riboside & nicotinamide mononucleotide, and caloric restriction. We also chat about some of the companies working in this area, as well as novel business models that may or may not be a strategy to enable rigorous research of something as difficult to study as human lifespan.

Dr. Charles Brenner, Chief Scientific Advisor at ChromaDex, and the Roy J. Carver Chair & Head of Biochemistry at the University of Iowa discusses a landmark first-of-a-kind preclinical study on lactating and breastfeeding mothers that received a supplement of NR, nicotinamide riboside (Niagen) a unique B3 vitamin. Visit www.hpr.fm to listen to more interviews about healthcare and research findings.

The Annual Biohacking Conference, hosted by Upgrade Labs, is a mind-boggling, mind-enhancing gathering of people, from all walks of life, who want to live better and longer. LLAMA’s Peter Bowes attended this year’s event, in Beverly Hills, California, to meet Dave Asprey, the movement’s poster boy for self-improvement, along with some of the conference’s key speakers and exhibitors. In this episode we explore everything from cryotherapy to enhancing neuroplasticity, flow meditation, mitochondrial health and infrared saunas. Dave explains how biohacking has come of age, why he believes he will live to be at least 180 and how he says everyone - not just the rich and famous - could benefit from being in better control of their bodies and biology. 01:52Dave AspreyFounder, BulletproofDave, the original biohacker, explains how and why the practice has come of age and how we can all benefit from it."Biohacking is largely the art and science of changing the environment around you, so that you have more control of your biology.”Also check out: LLAMA episode 65, with Peter’s tour of Upgrade Labs in Santa Monica. Martin Tobias: Biohacking to upgrade the human mind and body12:24Dr. Barry MorguelanChinese energy grandmaster, double board certified gastroenterologist and internal medicine doctor trained at UCLA and currently practicing in Los Angeles. Dr. B, as he is affectionately known, is a force of nature with a mind-blowing story of personal discovery and experience. 21:54Dr. Charles BrennerHead of Biochemistry at the University of Iowa & chief scientific adviser to the Chromadex, a California-based nutraceutical company behind the Nicotinamide riboside (NR) supplement, Tru Niagen. Dr. Brenner updates us on his work understanding NAD and cell metabolism.Also check out our previous interview: LLAMA episode 53Charles Brenner: Explaining the science behind “age better” vitamin B3 supplement26:32Lauren Hansen, Cryo ScienceLearn about the Cryotherapy craze. Lauren explains the science of exposing the body to subzero temperatures in order to stimulate physical and mental health benefits.32:26Dr. Patrick Porter, BrainTapDr. Porter hacks the power nap with "brainwave entrainment" technology. Through guided-audio programs and creative visualization processes, an app allows users to "relax, reboot, and revitalize while achieving peak brain performance.” 41:14Tom Griffin, Halo NeuroscienceTom explains the science behind a headset fitted with electrodes that put your brain in a more “excited and malleable state” for an hour. For athletes, Tom explains that the headset works by applying a small electric current to the part of the brain that controls movement, activating neurons so they fire more often during training.44:15Dr. Chris Shade, Quicksilver ScientificKeto or Kale? If the former is your diet of choice, Dr. Shade explains how a ketogenic diet works and how he has developed a system to hack - i.e. speed up - the process. So what is Keto Before 6?50:09James Brown, Vedic MeditationStep back and go with the flow. James explains Vedic Meditation and how it allows the mind the settle, without trying too hard. 1:00:20Dr. Raleigh Duncan, Clearlight InfraredInfrared suanas have attracted a huge amount buzz recently. But how do help us hack our health and athletic recovery? Peter steps inside a hot yoga cubicle to find out more.

Dr. Alyssa Dweck, MS MD FACOG, an OB-GYN discusses this landmark new study on lactating and breastfeeding rodent mothers that were supplemented with this unique B3 vitamin nicotinamide riboside (NR-NiagenÒ, Chromadex). Listen to more health-related stories and research updates at www.hpr.fm

Our guest today is Dr. Charles Brenner, the Roy J. Carver Chair of Biochemistry at the University of Iowa. Charles is one of the world’s leading experts on nicotinamide adenine dinucleotide, commonly referred to as NAD, which is an essential molecule found in every living cell.  In 2004, he discovered the nicotinamide riboside kinase pathway, which leads to a special form of vitamin B3. We talk to Charles about his research into NAD and why he believes supplementation with NR could help people age better. In addition to his work at the University of Iowa, he is also the chief scientific advisor for ChromaDex, which markets the NR supplement Tru Niagen. Toward the end of our interview, Charles talks about dozens of exciting new papers and studies that are on the horizon. One of those papers - Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring- was published in Cell Reports on the same day as our interview with Charles went live. Also in today’s interview, we discuss: [00:06:29] How Charles became the first cancer biology graduate student in the biology department at Stanford University. [00:07:51] Charles’ research into nicotinamide adenine dinucleotide (NAD) during his time on the faculty at Thomas Jefferson University. [00:09:15] Charles’ discovery that nicotinamide riboside (NR) is a precursor of NAD. [00:19:47] Why Charles doesn’t use the term “anti-aging.” [00:25:52] The importance of nicotinamide adenine dinucleotide phosphate (NADPH) and its role as the central regulator of reactive oxygen species toxicity. [00:34:56] The circadian rhythms of NAD and the potential benefit of diurnal dosing. [00:38:45] Why skeletal muscle is one of the most sensitive target tissues for the anti-aging effects of NMN. [00:45:42] How the benefits of a ketogenic diet, intermittent fasting, time restricted eating could be related to NAD. [00:47:02] A recent human trial conducted by the University of Colorado that found Niagen increased NAD+ by 60 percent in healthy middle-aged and older adults after just six weeks. [00:49:19] The optimal dose of NR for humans. Show notes: [00:03:06] Charles talks about growing up as a kid who dreamed about becoming either a comedian or rabbi. [00:03:26] Charles describes his success on the math team in high school and how he also enjoyed playing tennis and running cross-country. [00:03:43] Charles reflects on his decision to attend Wesleyan University. [00:04:09] Although Charles decided to major in ecology, he found out upon arriving at Wesleyan that they did not have an ecology department. [00:05:05] Dawn mentions that after graduating with honors in biology, Charles traveled across the country to work in the Bay Area. She asks him what he did. [00:06:29] Charles talks about when and why he became interested in cancer research, and how he was the first cancer biology graduate student in the biology department at Stanford University. [00:07:51] Dawn asks about the work Charles did from 1996 to 2003 on nicotinamide adenine dinucleotide (NAD) during his time on the faculty at Thomas Jefferson University. [00:09:15] Ken brings up Charles’ research at Dartmouth, asking about his discovery that nicotinamide riboside (NR) is a precursor of NAD. [00:12:35] NAD is a coenzyme found in all living cells. It serves both as a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying electrons from one reaction to another, and as a co-substrate for other enzymes.  Charles gives an overview of the research into NAD and its relationship to overall health and age-related diseases. [00:19:47] Dawn asks Charles why he doesn’t use the term “anti-aging.” [00:20:54] Charles discusses how Verdin and numerous other investigators have reported that NADcontent declines with age in multiple organs, such as pancreas, adipose tissue, skeletal muscle,

There has been a lot of buzz recently surrounding a new supplement that could boost our energy levels as we grow old. It is a recently discovered form of vitamin B3 and has been widely touted as a possible tool to enhance the aging process. We are going to take a deep dive into what it is and how it works. Nicotinamide riboside (NR) is converted by the body into nicotinamide adenine dinucleotide (NAD) which is an essential molecule found in every living cell and plays a significant role in energy production, regulation of the circadian rhythm and cognitive function. Dr. Charles Brenner is one of the world’s leading authorities on the biochemistry behind NR and its potential to extend life in some organisms. Dr. Brenner is the Roy J. Carver Chair and Head of Biochemistry at the University of Iowa and founding co-director of the University of Iowa Obesity Initiative. He is also chief scientific adviser to Chromadex, a California-based company behind the NR supplement, Tru Niagen. In this in-depth interview, Dr Brenner explains the significance of NAD and why he believes supplementation with NR could help us "age better." He also elaborates on why he refuses to describe NR as “miraculous or magic” and explains why he is uncomfortable with the often-heard expression, 'anti-aging,’ in the marketing of human longevity.

A new program allowing in-house raw material testing without any up-front capital costs, is 'an exciting opportunity for industry', says Chromadex's VP of corporate development.

Frank Jaksch, President & CEO of ChromaDex talks with host Ric Franzi about his strategy, when he started ChromaDex in 1999, to make it the leader in the creation and supply of botanical reference standards.  In a consolidating industry, ChromaDex has differentiated itself by combining scientific rigor to its products and services along with an aggressive customer sales and service model.