Podcasts about N1

《N1文法30天必考攻略（附考前衝刺規劃手帳）》 博客來 ，誠品 ， 金石堂 --- 官方 DISCORD：點進去跟我們互動吧 本集教學內容：教學內容 來IG學更多：EZJapan IG -- Hosting provided by SoundOn

《N1文法30天必考攻略（附考前衝刺規劃手帳）》 博客來 ，誠品 ， 金石堂 --- 官方 DISCORD：點進去跟我們互動吧 本集教學內容：教學內容 來IG學更多：EZJapan IG -- Hosting provided by SoundOn

La marche était trop haute pour Loïs Boisson. La Française s'est inclinée en deux petits sets contre Coco Gauff en demi-finale du Grand Chelem parisien. Malgré cette défaite, sa quinzaine reste incroyable ! Elle est désormais 65e mondiale et N1 française... Où placer cet exploit dans l'histoire du tennis Français ? L'équipe revient sur la folle aventure de la Dijonnaise sans oublier le débrief du match entre Sabalenka et Swiatek. Dans la 2e partie de l'émission, pronostics des demies hommes. Au menu, deux chocs : Musetti vs Alcaraz et Djokovic vs Sinner. Quelle sera l'affiche de la finale ?

《N1文法30天必考攻略（附考前衝刺規劃手帳）》 博客來 ，誠品 ， 金石堂 --- 官方 DISCORD：點進去跟我們互動吧 本集教學內容：教學內容 來IG學更多：EZJapan IG -- Hosting provided by SoundOn

Adrian Maidment (Tauranga, NZ) and Riz Akhtar (Melbourne, AU) reunite for another high-voltage episode of the EV Quest podcast!Riz shares exclusive insights from his recent trip to China, diving deep into the scale and scope of BYD's electric ecosystem—from cars to buses, and SkyRail. Plus, they unpack major changes in BYD's distribution in Australia.Also in this episode:⭐ New Tesla Model 3 earns highest-ever ANCAP safety scores

《N1文法30天必考攻略（附考前衝刺規劃手帳）》 博客來 ，誠品 ， 金石堂 --- 官方 DISCORD：點進去跟我們互動吧 本集教學內容：教學內容 來IG學更多：EZJapan IG -- Hosting provided by SoundOn

《N1文法30天必考攻略（附考前衝刺規劃手帳）》 博客來 ，誠品 ， 金石堂 --- 官方 DISCORD：點進去跟我們互動吧 本集教學內容：教學內容 來IG學更多：EZJapan IG -- Hosting provided by SoundOn

"Jasno je da su u krizi i vlast i univerzitet - Vučić ne poseže za izborima kada želi da izađe iz situacije koja je za njena neprijatna, što je njegov uobičajeni trik - a univerzitet, jer postoji pad entuzijazma i nervoza među članovima akademske zajednice", kaže za N1 profesor Pravnog fakulteta Univerziteta u Beogradu Tanasije Marinković. On naglašava da onlajn nastava nije u skladu sa Zakonom o visokom obrazovanju, kao i da je potrebno formulisati nove vidove demokratske borbe.

即將邁入50歲，在金融業擔任高階主管的她，意外被迫離開職場。沒有名片、沒有身份，她該迅速回到職場？或是轉身投入家庭？她要如何重啟人生？ 這集節目的來賓是嫺人，在「被退休」後，她立即為自己賦予了3個新身份：管理自己退休金的經理人、部落格版主，以及英日語導遊候選人。於是她開始為自己的退休金務實理財、將心得寫在部落格，用功學日文甚至還通過日本能力N1的檢定，考取了英日語導遊以及外語領隊證照⋯⋯這些看似天馬行空的決定，如今都因為她的積極行動ㄒ而逐一開花結果。 她是怎麼做到的？ 嫺人分享： - 中年意外退休之後，如何為自己賦予新角色？ - 「清單控」也能用來規劃退休生活？ - 退休後，你會比自己想像的還抒懶？ - 如何維持學習的動力？ - 退休金要多少才夠？如何計算？ 主持人：《慢老》作者、天下雜誌網路專欄作者 黃惠如 來賓：《嫺人的好日子》部落格版主 嫺人 製作團隊：張雅媛、劉駿逸 ＊訂閱天下全閱讀：https://bit.ly/3STpEpV ＊下載天下雜誌App：https://bit.ly/3ELcwhX ＊意見信箱：bill@cw.com.tw -- Hosting provided by SoundOn

durée : 00:07:58 - L'invité de 8h15 de "ici Gascogne"

You know how they say “age is just a number”?  Try telling that to your hormones after 35. One day you're thriving, and the next your period ghosts you, your back is hurting and you're googling “what is perimenopause”. And maybe you still don't know ki perimenopause kuchh hota bhi hai. Kyunki na to kabhi mummy ne bataya na kabhi school mei padhaya.In Today's episode of Little Fixes, we're diving into the nitty-gritty of women's health after 35 with someone who knows exactly what's going on. I am talking to Gynaecologist & Fertility Expert Dr. Mahima Kak Nagpaul who's breaking down all the things your mom didn't tell you, your friends are too shy to discuss, and your Google search history is full of.From weird period changes to sex drive shifts, fertility to contraception, and health screenings to supplements we're unpacking it all, judgment-free and jargon-free.Dr Mahima is Senior Consultant at Activ Fertility and Gynae Clinic, N1, Greater Kailash Part 1, New Delhi 110048 Consultant Gynaecologist at Fortis La Femme Hospital in Greater Kailash Part 2So whether you're 35 and fabulous, 40 and figuring it out, or just curious about what's coming next- this one's for you.Please help us bring more such conversations to you, follow Little Fixes on your podcast app and share it with a woman you care about.Connect with Dr. Mahima Kak Nagpaul- https://www.instagram.com/dr.mahima.fertility/ Support the Podcast- https://www.buymeacoffee.com/maitrivermaConnect with @littlefixespodcast on Instagram https://www.instagram.com/littlefixespodcast/ Email me- littlefixespodcast@gmail.comDisclaimer- This podcast is only for educational and entertainment purposes. It doesn't intend to replace the guidance of trained professionals like doctors, psychiatrists, psychologists and coaches etc.Music Credit- Epidemic Sound

《N1文法30天必考攻略（附考前衝刺規劃手帳）》 博客來 ，誠品 ， 金石堂 --- 官方 DISCORD：點進去跟我們互動吧 本集教學內容：教學內容 來IG學更多：EZJapan IG -- Hosting provided by SoundOn

《N1文法30天必考攻略（附考前衝刺規劃手帳）》 博客來 ，誠品 ， 金石堂 --- 官方 DISCORD：點進去跟我們互動吧 本集教學內容：教學內容 來IG學更多：EZJapan IG -- Hosting provided by SoundOn

《N1文法30天必考攻略（附考前衝刺規劃手帳）》 博客來 ，誠品 ， 金石堂 --- 官方 DISCORD：點進去跟我們互動吧 本集教學內容：教學內容 來IG學更多：EZJapan IG -- Hosting provided by SoundOn

Like the saying goes, "better late than never", the Camerosity Podcast is back with Episode 91, which is dedicated to cameras of the 90s.  Which 90s you prefer, 1890s or 1990s, all 90s cameras are welcome! Joining Anthony, Paul, Theo, Stephen, and Mike are returning callers, AJ Gentile, Ira Cohen, Miles Libak, Nick Marshall, Robert Rotoloni, and Will Pinkham and we cover a wide range of 1990s cameras and technologies.  Paul starts off with some stories about mini labs and how single use cameras became a big thing.  We dive into bridge cameras, including the Olympus IS-2 which Mike gave rave remarks to. We discuss a large number of point and shoot cameras including premium models by Nikon and Konica, and ponder why the Olympus Stylus Epic is so popular today.  We talk about some dead end technologies from the 90s such as Minolta's ill fated Creative Expansion and Canon's obscure barcode scanner for the EOS 10S. Not all technologies from the 1990s were failures though as the 1990s was the first decade of digital cameras.  Models like the floppy disc Sony Mavica and Nikon D1 were great cameras with a historical significance which helped prove that digital photography had arrived. We round out the discussion with why Theo loves the Mamiya 7 so much and how it compares to the Mamiya 6, Robert shares some info on the development of the Nikon S3 2000 edition, and we have a thorough discussion on Kyocera's Contax SLRs. As always, the topics we discuss on the Camerosity Podcast are influenced by you!  Please don't feel like you have to be an expert on a specific type of camera, or have the level of knowledge on par with other people on the show.  We LOVE people who are into shooting or collecting cameras, no matter how long you've been doing it, so please don't consider your knowledge level to be a prerequisite for joining! The guys and I rarely know where each episode is going to go until it happens, so if you'd like to join us on a future episode, be sure to look out for our show announcements on our Camerosity Podcast Facebook page, the Camerosity Discord server, and right here on mikeeckman.com. We usually record every other Monday and announcements, along with the Zoom link are typically shared 2-3 days in advance. For our next episode, we decided to explore the Italian camera industry as its not often discussed in camera collector circles.  While Germany, Japan, the Soviet Union, and the United States were well known as makers of fine cameras, a great number of really cool cameras were made in Italy such as the Rectaflex, Ducati Sogno, Gamma II, and other models by Bencini, Durst, and Ferrania.  Join us if you're a fan of cameras from this "boot shaped" country, and see if we can manage to fill an entire episode without getting distracted!  We will record Episode 92 on Monday, May 19th at 7pm Central Daylight Time and 8pm Eastern Daylight Time. In This Episode Jeff and Gabe Can't Pronounce French Names / Alan Peres Sends Us Emails Now Sometimes Its Hard to Remember That We Like Cameras from the 1990s The 1990s Was the Decade of the MiniLab and Single Use Disposable Cameras Olympus Invested Heavily in Point and Shoots in the late 1980s In the 1990s, Olympus Gave Up on Traditional SLRs and Created the IS-Series Olympus IS-2 / In the 90s Zoom Reach was Over Valued By Novices Why Are the Olympus Stylus Epics so Expensive? / µ[mju:]-II Nikon F5 Improvements Over the F4 / Paul Really Hates the Nikon N70 The Nikon N90/F90 Was Nikons Best Semi-Pro SLR of the 1990s Broken Battery and Film Doors Were a Huge Problem Back Then The Nikon 28Ti and 35Ti Are Impressive Cameras but Terrible Investments 1990s Underwater Cameras / How Many People Kept Shooting 80s Cameras in the 90s? Contax S2 and Other 1990s Contax SLRs / Contax S2 and ST Mike Likes the Contax RTS II and the Contax RX / Large Contaxes Like the N1 and AX The Minolta Maxxum 600si/650si Has Mechanical Knobs and is Awesome / Minolta Maxxum 9xi Minolta's Horrible Creative Expansion Cards / Disabling Features on Consumer SLRs / Canon Barcode Scanning System The Canon EOS-1n RS / Pellicle Mirrors / Canon EOS A2E / Canon's Eye Control System Premium Point and Shoots / Konica Hexar AF / Canon Elph Theo Loves the Mamiya 7 / Mamiya 6 / Everyone's First 110 Camera Nikon Started Working on the S3 2000 in the 1990s / Differences Between the 2000 and Original S3 Sony Floppy Mavica Cameras / Nikon D1 Alfred C. Kemper Kombi from the 1890s / Theo's 1890s Australian Studio Cameras Advanced Photo System (APS) Film and Cameras / Kodak Advantix Preview Links The Camerosity Podcast is now on Discord! Join Anthony, Paul, Theo, and Mike on our very own Discord Server. Share your GAS and photography with other listeners in the Lounge or in our dedicated forums. If you have questions for myself or the other guys, we have an “Ask the Hosts” section as well where you can get your question answered on a future show! Check it out! https://discord.gg/PZVN2VBJvm. If you would like to offer feedback or contact us with questions or ideas for future episodes, please contact us in the Comments Section below, our Camerosity Facebook Group, Instagram page, or Discord server. The Official Camerosity Facebook Group - https://www.facebook.com/groups/camerositypodcast Camerosity Instagram - https://www.instagram.com/camerosity_podcast/ Keppler's Vault 101: Advanced Photo System - https://mikeeckman.com/2022/03/kepplers-vault-101-advanced-photo-system/ Theo Panagopoulos - https://www.photothinking.com/ Paul Rybolt - https://www.ebay.com/usr/paulkris - https://thisoldcamera.net/ Anthony Rue - https://www.instagram.com/kino_pravda/

Ian Cameron, the Chairperson of Parliament's Portfolio Committee on Police, has been the target of a virulent attack by The Police and Prisons Civil Rights Union (POPCRU) for labelling as “thugs” Deputy President Paul Mashatile's VIP Protection officers who were involved in a “brutal” assault on “innocent” civilians next to the N1 in Johannesburg in 2023 - but were acquitted following an internal disciplinary hearing - despite video evidence. “In a parliamentary context, as part of my constitutional duty to do oversight, I'm not going to allow any union to make me look or seem or feel like just being a rubber stamp that needs to simply approve anything they say or do. There's something very wrong with the process that was followed here and it's critical for us to dissect it.” As for the mysterious deaths of four police officers whose bodies were found in the Hennops River recently, Cameron says: “I do find it suspicious, and it's not to cast doubt on any part of an investigation or anything like that, but it is an extraordinary kind of event….So it would be very interesting to understand more of the depth and context as to what exactly those members were involved with.” Cameron also gives an update on the biggest issues his committee is currently grappling with, including the proposed regulatory amendments of PSiRA that “in essence mean that in a very arbitrary way, a security company can lose its function overnight”.

《N1文法30天必考攻略（附考前衝刺規劃手帳）》 博客來 ，誠品 ， 金石堂 --- 官方 DISCORD：點進去跟我們互動吧 本集教學內容：教學內容 來IG學更多：EZJapan IG -- Hosting provided by SoundOn

There has been quite an outcry following the acquittal of eight SAPS VIP Protection Unit officers attached to Deputy President Paul Mashatile, following an internal SAPS disciplinary process.. Lester Kiewit speaks to Lesiba Thobakgale, the spokesperson for the SA Police Union, and to Ulrich Roux, the legal representative of three of the (four) victims of the N1 highway assault. Good Morning Cape Town with Lester Kiewit is a podcast of the CapeTalk breakfast show. This programme is your authentic Cape Town wake-up call. Good Morning Cape Town with Lester Kiewit is informative, enlightening and accessible. The team’s ability to spot & share relevant and unusual stories make the programme inclusive and thought-provoking. Don’t miss the popular World View feature at 7:45am daily. Listen out for #LesterInYourLounge which is an outside broadcast – from the home of a listener in a different part of Cape Town - on the first Wednesday of every month. This show introduces you to interesting Capetonians as well as their favourite communities, habits, local personalities and neighbourhood news. Thank you for listening to a podcast from Good Morning Cape Town with Lester Kiewit. Listen live – Good Morning CapeTalk with Lester Kiewit is broadcast weekdays between 06:00 and 09:00 (SA Time) https://www.primediaplus.com/station/capetalk Find all the catch-up podcasts here https://www.primediaplus.com/capetalk/good-morning-cape-town-with-lester-kiewit/audio-podcasts/good-morning-cape-town-with-lester-kiewit/ Subscribe to the CapeTalk daily and weekly newsletters https://www.primediaplus.com/competitions/newsletter-subscription/ Follow us on social media: CapeTalk on Facebook: www.facebook.com/CapeTalk   CapeTalk on TikTok: www.tiktok.com/@capetalk   CapeTalk on Instagram: www.instagram.com/capetalkza  CapeTalk on X: www.x.com/CapeTalk  CapeTalk on YouTube: www.youtube.com/@CapeTalk567  See omnystudio.com/listener for privacy information.

Action Society sê die vryspraak van agt polisiebeamptes van adjunkpresident Paul Mashatile se BBP-beskermingseenheid is 'n ernstige terugslag vir geregtigheid en polisie-aanspreeklikheid. Die beamptes, bekend as die “blouligmafia”, is in Julie 2023 op die N1-snelweg in Johannesburg afgeneem terwyl hulle burgerlikes aangerand het, maar is in 'n interne dissiplinêre verhoor vrygespreek. Woordvoerder van die organisasie, Juanita du Preez, sê die uitslag stuur 'n gevaarlike boodskap en traumatiseer die slagoffers opnuut:

《N1文法30天必考攻略（附考前衝刺規劃手帳）》 博客來 ，誠品 ， 金石堂 --- 官方 DISCORD：點進去跟我們互動吧 本集教學內容：教學內容 來IG學更多：EZJapan IG -- Hosting provided by SoundOn

Lester Kiewit speaks to Ian Cameron, the chair of the portfolio committee on police, who says he will be approaching the Minister of Police and the National Commissioner to demand an explanation for the acquittal by SAPS of eight VIP unit members who were filmed assaulting members of the public on the N1. The officers were part of Deputy President Paul Mashatile’s protection unit. Good Morning Cape Town with Lester Kiewit is a podcast of the CapeTalk breakfast show. This programme is your authentic Cape Town wake-up call. Good Morning Cape Town with Lester Kiewit is informative, enlightening and accessible. The team’s ability to spot & share relevant and unusual stories make the programme inclusive and thought-provoking. Don’t miss the popular World View feature at 7:45am daily. Listen out for #LesterInYourLounge which is an outside broadcast – from the home of a listener in a different part of Cape Town - on the first Wednesday of every month. This show introduces you to interesting Capetonians as well as their favourite communities, habits, local personalities and neighbourhood news. Thank you for listening to a podcast from Good Morning Cape Town with Lester Kiewit. Listen live – Good Morning CapeTalk with Lester Kiewit is broadcast weekdays between 06:00 and 09:00 (SA Time) https://www.primediaplus.com/station/capetalk Find all the catch-up podcasts here https://www.primediaplus.com/capetalk/good-morning-cape-town-with-lester-kiewit/audio-podcasts/good-morning-cape-town-with-lester-kiewit/ Subscribe to the CapeTalk daily and weekly newsletters https://www.primediaplus.com/competitions/newsletter-subscription/ Follow us on social media: CapeTalk on Facebook: www.facebook.com/CapeTalk   CapeTalk on TikTok: www.tiktok.com/@capetalk   CapeTalk on Instagram: www.instagram.com/capetalkza  CapeTalk on X: www.x.com/CapeTalk  CapeTalk on YouTube: www.youtube.com/@CapeTalk567  See omnystudio.com/listener for privacy information.

《N1文法30天必考攻略（附考前衝刺規劃手帳）》 博客來 ，誠品 ， 金石堂 --- 官方 DISCORD：點進去跟我們互動吧 本集教學內容：教學內容 來IG學更多：EZJapan IG -- Hosting provided by SoundOn

It is estimated that about N1 billion was lost to a devastating fire that tore through Jos Main Market, destroying over 500 shops. For many traders, it wasn't just a fire—it was the loss of their entire livelihood. In this episode of Nigeria Daily, we explore the causes of the tragedy, its economic impact, and what can be done to prevent future incidents

《N1文法30天必考攻略（附考前衝刺規劃手帳）》 博客來 ，誠品 ， 金石堂 --- 官方 DISCORD：點進去跟我們互動吧 本集教學內容：教學內容 來IG學更多：EZJapan IG -- Hosting provided by SoundOn

掌握台灣與國際間時事的脈動累積出實用的，股票期貨選擇權，操盤技巧每天多學一點，生活好一點邀請你加入股票王的訂閱方案每天盤前盤中，了解最新類股輪動與飆股變化讓你不知不覺，邁向財富自由的道路 https://fstry.pse.is/7g22d4 —— 以上為 Firstory Podcast 廣告 —— 【想看影片版？直接點這裡看更多！YouTube：https://youtu.be/DFATTrvhwv0】 古鎮榮曾經擔任過外商銀行的法務、民生報及聯合報記者，卻在40歲那一年轉行當領隊。令人好奇，中年職涯大轉彎，需不需要勇氣？ 他原本一句日文都不會說，從「あいうえお」開始學起，2年後通過日文N1測驗，在考取英日語領隊證照之後，剛開始帶的是冷門團，但機緣發生在2016年，外商銀行的老同事邀他帶黑卡團，結果大受好評，目前帶過日本七星列車、四季島列車等豪華團，甚至是傳説中的環遊世界50天團，到底他成功跨界的祕訣是什麼？ 本集金句： 我覺得做自己覺得快樂的事情是很重要的，所以我才會覺得說，在他們登上七頂峰、完成這個任務的歷史時刻，我應該要在現場。另外一個就是說學日文，我從五十音開始學，我根本沒想過什麼N2、N1，要去考試這件事情，不管我學到哪裡，這個過程我是很快樂的。 #古鎮榮 #旅遊 #領隊 #登山 #記者 #轉職 #寶島聯播網 #寶島有意思 ---寶島有意思 準時放送--- 19：00~~~> 北部-寶島新聲 FM98.5 嘉義-嘉義之音FM91.3 高雄-主人電台FM96.9 21：00~~~> 中部-大千電台 FM99.1 ---------- 寶島有意思》挖掘台灣有意思的在地人、事、物。 寶島聯播網》以「本土電台」為品牌定位，用心傳承台灣在地文化，傳遞台語流行音樂之美。https://www.baodaoradio.com.tw/ 寶島好康商城》堅持提供高品質、安心、實惠的好康產品。https://www.bodogo.com.tw/ 小額贊助支持本節目： https://open.firstory.me/user/clw4248xv113d01wg7s4h2xnr 留言告訴我你對這一集的想法： https://open.firstory.me/user/clw4248xv113d01wg7s4h2xnr/comments Powered by Firstory Hosting

Transport Minister, Barbara Creecy together with her deputy, Mkhuleko Hlengwa are interacting with drivers at Kranskop on the N1 as travelers head back to their destinations following the Easter Weekend. Creecy is encouraging drivers to remain vigilant and drive safety in order to arrive safely. She also notes that it remains concerning that a drunk driver attempted to bribe a traffic officer and will be appearing in court on Tuesday. Bongiwe Zwane spoke to SABC Reporters, Fanele Mhlongo and Motsebi Monareng

Đối với người nước ngoài, tại Pháp, tiếng Pháp trở thành một trong những điều kiện bắt buộc để được cấp thẻ cư trú và hội nhập vào xã hội. Từ tháng 07/2025, người xin thẻ cư trú hoặc quốc tịch Pháp có ba cách để chứng minh trình độ tiếng Pháp : có bằng cấp của Pháp ; bất kỳ bằng chứng nào khác chứng minh thành thạo tiếng Pháp ; chứng chỉ ngôn ngữ tương ứng với mỗi loại thẻ cư trú : A2 cho thẻ từ 2-4 năm, B1 cho thẻ 10 năm và B2 để xin quốc tịch. Chứng chỉ A2 tương đương với trình độ học sinh cấp 2, B1 tương đương với cấp 3 và B2 tương đương với trình độ đại học. Một điều kiện thắt chặt khác là sau khi đã ba lần có thẻ cư trú một năm, người nước ngoài phải xin thẻ cư trú nhiều năm, và như vậy, cần chứng chỉ tiếng Pháp A2. Nếu không chứng minh được, đơn xin có thể bị từ chối, dù đã sống ổn định ở Pháp hoặc đoàn tụ gia đình. Riêng về xin quốc tịch, điều kiện về tiếng Pháp cũng bị thắt chặt hơn, cần trình độ B2 (nói, viết) kể từ tháng 07/2025 thay vì B1 như hiện nay.Quy định thắt chặt mới được ghi rõ trong Thông tư bộ trưởng Nội Vụ Bruno Retailleau tháng 01/2025 và có hiệu lực cho đến khi có luật nhập cư mới, dự kiến vào năm 2026. Bộ trưởng Othaman Nasrou, phụ trách Quyền Công dân và Chống phân biệt, khẳng định là chính quyền “sẽ khắt khe hơn về mặt hòa nhập xã hội”. Đọc thêm : Học tiếng Pháp với giáo trình Parlez-vous Paris của RFIĐể tạo thuận lợi cho người nước ngoài học tiếng Pháp, chính quyền triển khai nhiều phương tiện dạy học. Tuy nhiên, các lớp học trực tiếp, có giáo viên hướng dẫn chỉ còn dành cho người mới đến, chưa biết tiếng Pháp. Còn đối với người đã biết tiếng Pháp, họ có rất nhiều trang web tự học và trắc nghiệm trình độ (tham khảo trang FUN MOOC). Chính điều này khiến các tổ chức phi chính phủ, hiệp hội giúp đỡ người nhập cư, tị nạn lo ngại và lên án vì như bỏ rơi người nhập cư, mặc họ tự xoay sở.Trả lời RFI Tiếng Việt ngày 04/04/2025 khi nói về việc chính phủ “thắt chặt kiểm soát nhập cư bất hợp pháp và tiến trình hội nhập”, ông Félix Guyon, trường THOT chuyên dạy tiếng Pháp cho người tị nạn và xin tị nạn ở vùng Ile-de-France, nêu một thực tế là không phải người nước ngoài nào cũng có điều kiện vật chất (máy tính, máy tính bảng) hoặc có kết nối internet tốt để có thể tự luyện tập.Các hiệp hội tổ chức lớp học tiếng Pháp miễn phí cho người nước ngoàiTuy nhiên, để bổ sung cho “sự giảm cam kết của Nhà nước”, theo cáo buộc của các hiệp hội bảo vệ người tị nạn, di dân nước ngoài, có hàng nghìn chương trình dạy tiếng Pháp, đặc biệt là ở vùng Ile-de-France (Paris và vùng phụ cận), được các hiệp hội và trường tư tổ chức miễn phí cho người nhập cư. Trường THOT (viết tắt của Transmettre un Horizon à tous, Truyền tải cả một chân trời đến mọi người) là một trong số đó. Ông Félix Guyon giải thích :“Hiện tại, trường THOT có 6 lớp học với khoảng 15 học viên mỗi lớp. Mỗi kỳ chúng tôi nhận được từ 200 đến 500 đăng ký. Do số lượng yêu cầu nhiều hơn số chỗ cho nên chúng tôi phải tuyển chọn học viên dựa trên các tiêu chí như không có bằng cấp, không nói được tiếng Pháp hoặc nói được ít tiếng Pháp, sống ở vùng Île-de-France và có thể học được 10 giờ mỗi tuần. Họ được yêu cầu đến làm bài kiểm tra để xếp vào lớp có trình độ tương ứng. Đối với những người mà chúng tôi không thể tiếp đón được, chúng tôi sẽ cố gắng hướng dẫn họ, cung cấp cho họ địa chỉ và thông tin liên lạc của những nơi khác - có rất nhiều cơ sở ở Paris và vùng lân cận - để họ có thể nhanh chóng tìm được lớp học phù hợp. Chúng tôi có rất nhiều yêu cầu và đáng tiếc là chúng tôi không thể đáp ứng được hết”.Người nước ngoài muốn học tiếng Pháp có thể truy cập vào các trang web hoặc ứng dụng, như BonjourBonjour hoặc Réseau Alpha.... chọn “học trực tiếp” hoặc “học trực tuyến (online)”, chọn khu vực sinh sống để có thể tìm được một khóa học phù hợp với nhu cầu. Những khóa học này đều miễn phí, theo ông Félix Guyon :“Trường chúng tôi đặt mức lệ phí nhập học là 7 euro. Thực ra đây chỉ là mức phí mang tính biểu tượng nhằm tạo ra cam kết và hợp đồng giữa nhà trường và học viên. Chúng tôi cho rằng đây là một ý tưởng hay để cải thiện sự chăm chỉ, để hiệu quả hơn so với các khóa học hoàn toàn miễn phí. Dĩ nhiên là khoản phí này không thể chi trả cho toàn bộ kinh phí cho giảng viên, cơ sở vật chất và nhân viên. Nhưng ý tưởng của chúng tôi là lập ra một kiểu hợp đồng, một chút trách nhiệm, niềm tin giữa người học và nhà trường. Phần còn lại, chúng tôi phải đi tìm ngân sách từ các nguồn trợ cấp công, từ các tổ chức doanh nghiệp, quỹ tư nhân và quyên góp của cá nhân. Trọng trách của chúng tôi là phải tìm được nguồn tài trợ để có thể mở trường và tiếp nhận các học viên đó gần như miễn phí hết”.Không có giấy tờ hợp lệ cũng có thể đăng ký họcTHOT được ba phụ nữ đồng sáng lập năm 2015 sau các sự kiện Mùa Xuân Ả Rập và chiến tranh ở Syria. Họ trực tiếp đến các khu tạm trú hỗ trợ người tị nạn và thấy rằng ngoài mong muốn có được mái nhà che mưa che nắng, được ăn uống bình thường, những di dân đến Paris, vùng Île-de-France hoặc Pháp thực sự muốn học tiếng Pháp giúp hòa nhập hiệu quả vào nước Pháp, được hội nhập vào xã hội Pháp.“Trường THOT nhận được một số ngân sách dành cho một số kiểu quy chế. Ví dụ, Nhà nước cấp ngân sách cho chúng tôi để đào tạo người có quy chế tị nạn. Nhưng chúng tôi cũng có nhiều nguồn ngân sách khác, từ các cá nhân, các quỹ tư nhân giúp chúng tôi tiếp nhận cả những người không có giấy tờ hoặc đang xin tị nạn hoặc bị từ chối quyền tị nạn. Đối với những trường hợp như vậy, chúng tôi thực sự ủng hộ ý tưởng là tất cả người nước ngoài ở Pháp đều được quyền tiếp cận những điều kiện tốt để học tiếng Pháp.Chúng tôi có những khóa học tiếng Pháp kéo dài 160 giờ phù hợp với trình độ của từng cá nhân và được giảng dạy bởi một giảng viên có trình độ chuyên môn, từ “vỡ lòng” dành cho những người không biết đọc, biết viết lên đến trình độ A2”. Đọc thêm : Học tiếng Pháp qua bản tin thời sựChính vì vậy, thẻ cư trú - được coi là giấy tờ tùy thân - không phải là một điều kiện bắt buộc khi đăng ký học tại những ngôi trường dạy tiếng này. Tuy nhiên, khi đến giai đoạn hỗ trợ tìm việc làm hoặc một ngành đào tạo chuyên môn, vấn đề thẻ cư trú lại là một trở ngại, theo giải thích của ông Félix Guyon :“Ở điểm này, đúng là chúng tôi bị hạn chế vì quy chế của học viên, có nghĩa sẽ không thể đăng ký đào tạo chuyên môn cho một người không có giấy tờ. Chúng tôi sẽ phải cố gắng hỗ trợ nhiều nhất để giúp họ hợp thức hóa giấy tờ tùy theo hoàn cảnh cá nhân hoặc có tiến triển trong hồ sơ di trú. Nhưng chúng tôi sẽ không thể tìm việc làm cho người không có giấy tờ vì điều đó là bất hợp pháp. Vì vậy, chúng tôi phải theo hoàn cảnh của từng người, cố gắng giúp họ thay đổi hoàn cảnh và nhất là nâng cao trình độ tiếng Pháp. Sử dụng tốt tiếng Pháp sẽ luôn hữu ích cho họ, bất kể số phận của họ như thế nào, bất kể chặng đường còn lại của họ ra sao. Khi có trình độ tiếng Pháp tốt hơn, họ sẽ tự lập hơn, tự tin hơn vì ngoài ngôn ngữ, đây là những kỹ năng rất quan trọng cho chuỗi hành trình còn lại”.Tạo điều kiện, đồng hành để đi tới thành côngKhông chỉ dạy tiếng Pháp, theo dõi quá trình học tập và tiến bộ của học viên, hầu hết các trường dạy tiếng cho người nước ngoài đều tổ chức thêm các hoạt động văn hóa, thể thao, dịch vụ tư vấn pháp lý di dân, tị nạn và xã hội.“Ví dụ, tại trường THOT có tổ tư vấn pháp lý, định hướng nghề nghiệp, hỗ trợ tâm lý trị liệu và cả nhà trẻ để những phụ nữ thường phải trông con có thể gửi con nhỏ trong giờ học. Mục tiêu thực sự là tạo ra một nơi hiệu quả và chu đáo để mọi người đến trường chúng tôi đều có thể học tiếng Pháp hiệu quả nhất có thể và trong điều kiện tốt nhất.Tất cả các tổ tư vấn quanh các khóa học nhằm mục đích bảo đảm rằng khi đến lớp, đứng trước giáo viên, học viên có thể sẵn sàng về mặt tinh thần và sau đó là tự tin để có thể học tiếng Pháp hiệu quả và đạt được bằng tốt nghiệp đầu tiên bởi vì trong trường của chúng tôi, có những người chưa từng có bằng cấp nào ở nước của họ hoặc ở Pháp. Do đó chứng chỉ tiếng DILF (Diplôme Initial de Langue Française, chứng chỉ tiếng Pháp dành cho người mới bắt đầu) hoặc DELF (Diplôme d'Etudes en Langue Française, bằng tiếng Pháp cơ bản cấp A1) mà chúng tôi giúp họ đạt được, sẽ là bằng tốt nghiệp đầu tiên trong cuộc đời họ. Việc đó sẽ hữu ích trong việc tìm kiếm việc làm và con đường sự nghiệp, đồng thời cũng có tác động tích cực đến sự tự tin, tự chủ của họ”.Thông tư Retailleau tháng 01/2025 thắt chặt yêu cầu về tiếng Pháp để hội nhập không ảnh hưởng đến người có quy chế tị nạn vì được luật pháp quốc tế bảo vệ. Họ sẽ không thể bị trục xuất nếu không đạt đến một trình độ ngôn ngữ yêu cầu. Còn tất cả những người nước ngoài khác sẽ phải chứng minh trình độ tiếng Pháp tương ứng. Chính phủ Pháp nhấn mạnh nhiều nước trên thế giới đã áp dụng yêu cầu trắc nghiệm ngôn ngữ.Ví dụ Cơ quan Di trú và Thị thực Vương quốc Anh (UKVI) chấp nhận bài kiểm tra Secure English Language Tests (SELTs). Tại Canada, người nước ngoài xin thị thực hoặc xin nhập quốc tịch đều phải tham gia Kiểm tra trình độ tiếng Pháp (TCF), gồm bốn bài đánh giá kỹ năng hiểu nói/viết và khả năng diễn đạt nói/viết. Nhật Bản cũng yêu cầu người nước ngoài tham gia Kỳ thi năng lực tiếng Nhật (JLPT), được chia thành năm cấp độ. Đối với người muốn có thẻ thường trú nhân thì cần phải có trình độ N1 và đây là trình độ rất khó đạt được.FUN MOOC : Đại học Kỹ thuật số Pháp là nhóm lợi ích công cộng vận hành nền tảng FUN MOOC.Réseau Alpha : Được thành lập vào năm 2006 bởi hai tình nguyện viên người Pháp, hiệp hội Réseau Alpha giới thiệu chương trình học tiếng Pháp tại Île-de-France và cung cấp nguồn lực cho các tổ chức địa phương đầu tư vào việc học tiếng Pháp. Do đó, mục đích của hội là tạo ra mối liên kết giữa người học tiếng Pháp và những người hỗ trợ người di cư.

On The Midday Report today, host Mandy Wiener provides an in-depth look at the latest news headlines. Among the top stories, Timothy Omotoso’s accusers speak out. The trial-within-a-trial in the Joshlin Smith case reaches its conclusion. Mandy also gets a traffic update ahead of the Easter long weekend. Finally, Mandy speaks to the editor of Liberation Diaries – Reflection on 30 years of Democracy. This and more on the Midday Report. Listen live - The Midday Report with Mandy Wiener is broadcast on weekdays from noon to 1pm on 702 and CapeTalk.See omnystudio.com/listener for privacy information.

Dr. Ko Un “Clara” Park and Dr. Mylin Torres present the latest evidence-based changes to the SLNB in early-stage breast cancer guideline. They discuss the practice-changing trials that led to the updated recommendations and topics such as when SLNB can be omitted, when ALND is indicated, radiation and systemic treatment decisions after SLNB omission, and the role of SLNB in special circumstances. We discuss the importance of shared decision-making and other ongoing and future de-escalation trials that will expand knowledge in this space. Read the full guideline update, “Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer: ASCO Guideline Update” at www.asco.org/breast-cancer-guidelines. TRANSCRIPT This guideline, clinical tools, and resources are available at http://www.asco.org/breast-cancer-guidelines. Read the full text of the guideline and review authors' disclosures of potential conflicts of interest in the Journal of Clinical Oncology, https://ascopubs.org/doi/10.1200/JCO-25-00099       Brittany Harvey: Hello and welcome to the ASCO Guidelines podcast, one of ASCO's podcasts delivering timely information to keep you up to date on the latest changes, challenges and advances in oncology. You can find all the shows, including this one at asco.org/podcasts. My name is Brittany Harvey and today I'm interviewing Dr. Ko Un "Clara" Park from Brigham and Women's Hospital, Dana-Farber Cancer Institute, and Dr. Mylin Torres from Glenn Family Breast Center at Winship Cancer Institute of Emory University, co-chairs on “Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer: ASCO Guideline Update.” Thank you for being here today, Dr. Park and Dr. Torres. Dr. Mylin Torres: Thank you, it's a pleasure to be here. Brittany Harvey: And before we discuss this guideline, I'd like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO Conflict of Interest Policy is followed for each guideline. The disclosures of potential conflicts of interest for the guideline panel, including Dr. Torres and Dr. Park, who have joined us here today, are available online with the publication of the guideline in the Journal of Clinical Oncology, which is linked in the show notes. To start us off, Dr. Torres, what is the scope and purpose of this guideline update on the use of sentinel lymph node biopsy in early-stage breast cancer? Dr. Mylin Torres: The update includes recommendations incorporating findings from trials released since our last published guideline in 2017. It includes data from nine randomized trials comparing sentinel lymph node biopsy alone versus sentinel lymph node biopsy with a completion axillary lymph node dissection. And notably, and probably the primary reason for motivating this update, are two trials comparing sentinel lymph node biopsy with no axillary surgery, all of which were published from 2016 to 2024. We believe these latter two trials are practice changing and are important for our community to know about so that it can be implemented and essentially represent a change in treatment paradigms. Brittany Harvey: It's great to hear about these practice changing trials and how that will impact these recommendation updates. So Dr. Park, I'd like to start by reviewing the key recommendations across all of these six overarching clinical questions that the guideline addressed. So first, are there patients where sentinel lymph node biopsy can be omitted? Dr. Ko Un "Clara" Park: Yes. The key change in the current management of early-stage breast cancer is the inclusion of omission of sentinel lymph node biopsy in patients with small, less than 2 cm breast cancer and a negative finding on preoperative axillary ultrasound. The patients who are eligible for omission of sentinel lymph node biopsy according to the SOUND and INSEMA trial are patients with invasive ductal carcinoma that is size smaller than 2 cm, Nottingham grades 1 and 2, hormone receptor-positive, HER2-negative in patients intending to receive adjuvant endocrine therapy, and no suspicious lymph nodes on axillary ultrasound or if they have only one suspicious lymph node, then the biopsy of that lymph node is benign and concordant according to the axillary ultrasound findings. The patients who are eligible for sentinel lymph node biopsy omission according to the SOUND and INSEMA trials were patients who are undergoing lumpectomy followed by whole breast radiation, especially in patients who are younger than 65 years of age. For patients who are 65 years or older, they also qualify for omission of sentinel lymph node biopsy in addition to consideration for radiation therapy omission according to the PRIME II and CALGB 9343 clinical trials. And so in those patients, a more shared decision-making approach with the radiation oncologist is encouraged. Brittany Harvey: Understood. I appreciate you outlining that criteria for when sentinel lymph node biopsy can be omitted and when shared decision making is appropriate as well. So then, Dr. Torres, in those patients where sentinel lymph node biopsy is omitted, how are radiation and systemic treatment decisions impacted? Dr. Mylin Torres: Thank you for that question. I think there will be a lot of consternation brought up as far as sentinel lymph node biopsy and the value it could provide in terms of knowing whether that lymph node is involved or not. But as stated, sentinel lymph node biopsy actually can be safely omitted in patients with low risk disease and therefore the reason we state this is that in both SOUND and INSEMA trial, 85% of patients who had a preoperative axillary ultrasound that did not show any signs of a suspicious lymph node also had no lymph nodes involved at the time of sentinel node biopsy. So 85% of the time the preoperative ultrasound is correct. So given the number of patients where preoperative ultrasound predicts for no sentinel node involvement, we have stated within the guideline that radiation and systemic treatment decisions should not be altered in the select patients with low risk disease where sentinel lymph node biopsy can be omitted. Those are the patients who are postmenopausal and age 50 or older who have negative findings on preoperative ultrasound with grade 1 or 2 disease, small tumors less than or equal to 2 cm, hormone receptor-positive, HER2-negative breast cancer who undergo breast conserving therapy. Now, it's important to note in both the INSEMA and SOUND trials, the vast majority of patients received whole breast radiation. In fact, within the INSEMA trial, partial breast irradiation was not allowed. The SOUND trial did allow partial breast irradiation, but in that study, 80% of patients still received whole breast treatment. Therefore, the preponderance of data does support whole breast irradiation when you go strictly by the way the SOUND and INSEMA trials were conducted. Notably, however, most of the patients in these studies had node-negative disease and had low risk features to their primary tumors and would have been eligible for partial breast irradiation by the ASTRO Guidelines for partial breast treatment. So, given the fact that 85% of patients will have node-negative disease after a preoperative ultrasound, essentially what we're saying is that partial breast irradiation may be offered in these patients where omission of sentinel node biopsy is felt to be safe, which is in these low risk patients. Additionally, regional nodal irradiation is something that is not indicated in the vast majority of patients where omission of sentinel lymph node biopsy is prescribed and recommended, and that is because very few of these patients will actually end up having pathologic N2 disease, which is four or more positive lymph nodes. If you look at the numbers from both the INSEMA and the SOUND trial, the number of patients with pathologic N2 disease who did have their axilla surgically staged, it was less than 1% in both trials. So, in these patients, regional nodal irradiation, there would be no clear indication for that more aggressive and more extensive radiation treatment. The same principles apply to systemic therapy. As the vast majority of these patients are going to have node-negative disease with a low risk primary tumor, we know that postmenopausal women, even if they're found to have one to three positive lymph nodes, a lot of the systemic cytotoxic chemotherapy decisions are driven by genomic assay score which is taken from the primary tumor. And therefore nodal information in patients who have N1 disease may not be gained in patients where omission of sentinel lymph node biopsy is indicated in these low risk patients. 14% of patients have 1 to 3 positive lymph nodes in the SOUND trial and that number is about 15% in the INSEMA trial. Really only the clinically actionable information to be gained is if a patient has four or more lymph nodes or N2 disease in this low risk patient population. So, essentially when that occurs it's less than 1% of the time in these patients with very favorable primary tumors. And therefore we thought it was acceptable to stand by a recommendation of not altering systemic therapy or radiation recommendations based on omission of sentinel nodes because the likelihood of having four more lymph nodes is so low. Dr. Ko Un "Clara" Park: I think one thing to add is the use of CDK4/6 inhibitors to that and when we look at the NATALEE criteria for ribociclib in particular, where node-negative patients were included, the bulk majority of the patients who were actually represented in the NATALEE study were stage III disease. And for stage I disease to upstage into anatomic stage III, that patient would need to have pathologic N2 disease. And as Dr. Torres stated, the rate of having pathologic N2 disease in both SOUND and INSEMA studies were less than 1%. And therefore it would be highly unlikely that these patients would be eligible just based on tumor size and characteristics for ribociclib. So we think that it is still safe to omit sentinel lymph node biopsy and they would not miss out, if you will, on the opportunity for CDK4/6 inhibitors. Brittany Harvey: Absolutely. I appreciate you describing those recommendations and then also the nuances of the evidence that's underpinning those recommendations, I think that's important for listeners. So Dr. Park, the next clinical question addresses patients with clinically node negative early stage breast cancer who have 1 or 2 sentinel lymph node metastases and who will receive breast conserving surgery with whole breast radiation therapy. For these patients, is axillary lymph node dissection needed? Dr. Ko Un "Clara" Park: No. And this is confirmed based on the ACOSOG Z0011 study that demonstrated in patients with 1 to 3 positive sentinel lymph node biopsy when the study compared completion axillary lymph node dissection to no completion axillary lymph node dissection, there was no difference. And actually, the 10-year overall survival as reported out in 2017 and at a median follow up of 9.3 years, the overall survival again for patients treated with sentinel lymph node biopsy alone versus those who were treated with axillary lymph node dissection was no different. It was 86.3% in sentinel lymph node biopsy versus 83.6% and the p-value was non-inferior at 0.02. And so we believe that it is safe for the select patients who are early stage with 1 to 2 positive lymph nodes on sentinel lymph node biopsy, undergoing whole breast radiation therapy to omit completion of axillary lymph node dissection. Brittany Harvey: Great, I appreciate you detailing what's recommended there as well. So then, to continue our discussion of axillary lymph node dissection, Dr. Torres, for patients with nodal metastases who will undergo mastectomy, is axillary lymph node dissection indicated? Dr. Mylin Torres: It's actually not and this is confirmed by two trials, the AMAROS study as well as the SENOMAC trial. And in both studies, they compared a full lymph node dissection versus sentinel lymph node biopsy alone in patients who are found to have 1 to 2 positive lymph nodes and confirmed that there was no difference in axillary recurrence rates, overall survival or disease-free survival. What was shown is that with more aggressive surgery completion axillary lymph node dissection, there were higher rates of morbidity including lymphedema, shoulder pain and paresthesias and arm numbness, decreased functioning of the arm and so there was only downside to doing a full lymph node dissection. Importantly, in both trials, if a full lymph node dissection was not done in the arm that where sentinel lymph node biopsy was done alone, all patients were prescribed post mastectomy radiation and regional nodal treatment and therefore both studies currently support the use of post mastectomy radiation and regional nodal treatment when a full lymph node dissection is not performed in these patients who are found to have N1 disease after a sentinel node biopsy. Brittany Harvey: Thank you. And then Dr. Park, for patients with early-stage breast cancer who do not have nodal metastases, can completion axillary lymph node dissection be omitted? Dr. Ko Un "Clara" Park: Yes, and this is an unchanged recommendation from the earlier ASCO Guidelines from 2017 as well as the 2021 joint guideline with Ontario Health, wherein patients with clinically node-negative early stage breast cancer, the staging of the axilla can be performed through sentinel lymph nodal biopsy and not completion axillary lymph node dissection. Brittany Harvey: Understood. So then, to wrap us up on the clinical questions here, Dr. Park, what is recommended regarding sentinel lymph node biopsy in special circumstances in populations? Dr. Ko Un "Clara" Park: One key highlight of the special populations is the use of sentinel lymph node biopsy for evaluation of the axilla in clinically node negative multicentric tumors. While there are no randomized clinical trials evaluating specifically the role of sentinel lymph nodal biopsy in multicentric tumors, in the guideline, we highlight this as one of the safe options for staging of the axilla and also for pregnant patients, these special circumstances, it is safe to perform sentinel lymph node biopsy in pregnant patients with the use of technetium - blue dye should be avoided in this population. In particular, I want to highlight where sentinel lymph node biopsy should not be used for staging of the axilla and that is in the population with inflammatory breast cancer. There are currently no studies demonstrating that sentinel lymph node biopsy is oncologically safe or accurate in patients with inflammatory breast cancer. And so, unfortunately, in this population, even after neoadjuvant systemic therapy, if they have a great response, the current guideline recommends mastectomy with axillary lymph node dissection. Brittany Harvey: Absolutely. I appreciate your viewing both where sentinel lymph node can be offered in these special circumstances in populations and where it really should not be used. So then, Dr. Torres, you talked at the beginning about how there's been these new practice changing trials that really impacted these recommendations. So in your view, what is the importance of this guideline update and how does it impact both clinicians and patients? Dr. Mylin Torres: Thank you for that question. This update and these trials that inform the update represent a significant shift in the treatment paradigm and standard of care for breast cancer patients with early-stage breast cancer. When you think about it, it seems almost counterintuitive that physicians and patients would not want to know if a lymph node is involved with cancer or not through sentinel lymph node biopsy procedure. But what these studies show is that preoperative axillary ultrasound, 85% of the time when it's negative, will correctly predict whether a sentinel lymph node is involved with cancer or not and will also be negative. So if you have imaging that's negative, your surgery is likely going to be negative. Some people might ask, what's the harm in doing a sentinel lymph node biopsy? It's important to recognize that upwards of 10% of patients, even after sentinel lymph node biopsy will develop lymphedema, chronic arm pain, shoulder immobility and arm immobility. And these can have a profound impact on quality of life. And if there is not a significant benefit to assessing lymph nodes, particularly in someone who has a preoperative axillary ultrasound that's negative, then why put a patient at risk for these morbidities that can impact them lifelong? Ideally, the adoption of omission of sentinel lymph node biopsy will lead to more multidisciplinary discussion and collaboration in the preoperative setting especially with our diagnostic physicians, radiology to assure that these patients are getting an axillary ultrasound and determine how omission of sentinel lymph node biopsy may impact the downstream treatments after surgery, particularly radiation and systemic therapy decisions, and will be adopted in real world patients, and how clinically we can develop a workflow where together we can make the best decisions for our patients in collaboration with them through shared decision making. Brittany Harvey: Absolutely. It's great to have these evidence-based updates for clinicians and patients to review and refer back to. So then finally, Dr. Park, looking to the future, what are the outstanding questions and ongoing trials regarding sentinel lymph node biopsy in early-stage breast cancer? Dr. Ko Un "Clara" Park: I think to toggle on Dr. Torres's comment about shared decision making, the emphasis on that I think will become even more evident in the future as we incorporate different types of de-escalation clinical studies. In particular, because as you saw in the SOUND and INSEMA studies, when we de-escalate one modality of the multimodality therapy, i.e., surgery, the other modalities such as radiation therapy and systemic therapy were “controlled” where we were not de-escalating multiple different modalities. However, as the audience may be familiar with, there are other types of de-escalation studies in particular radiation therapy, partial breast irradiation or omission of radiation therapy, and in those studies, the surgery is now controlled where oftentimes the patients are undergoing surgical axillary staging. And conversely when we're looking at endocrine therapy versus radiation therapy clinical trials, in those studies also the majority of the patients are undergoing surgical axillary staging. And so now as those studies demonstrate the oncologic safety of omission of a particular therapy, we will be in a position of more balancing of the data of trying to select which patients are the safe patients for omission of certain types of modality, and how do we balance whether it's surgery, radiation therapy, systemic therapy, endocrine therapy. And that's where as Dr. Torres stated, the shared decision making will become critically important. I'm a surgeon and so as a surgeon, I get to see the patients oftentimes first, especially when they have early-stage breast cancer. And so I could I guess be “selfish” and just do whatever I think is correct. But whatever the surgeon does, the decision does have consequences in the downstream decision making. And so the field really needs to, as Dr. Torres stated earlier, rethink the workflow of how early-stage breast cancer patients are brought forth and managed as a multidisciplinary team. I also think in future studies the expansion of the data to larger tumors, T3, in particular,reater than 5 cm and also how do we incorporate omission in that population will become more evident as we learn more about the oncologic safety of omitting sentinel lymph node biopsy. Dr. Mylin Torres: In addition, there are other outstanding ongoing clinical trials that are accruing patients right now. They include the BOOG 2013-08 study, SOAPET, NAUTILUS and the VENUS trials, all looking at patients with clinical T1, T2N0 disease and whether omission of sentinel lymph node biopsy is safe with various endpoints including regional recurrence, invasive disease-free survival and distant disease-free survival. I expect in addition to these studies there will be more studies ongoing even looking at the omission of sentinel lymph node biopsy in the post-neoadjuvant chemotherapy setting. And as our imaging improves in the future, there will be more studies improving other imaging modalities, probably in addition to axillary ultrasound in an attempt to accurately characterize whether lymph nodes within axilla contain cancer or not, and in that context whether omission of sentinel lymph node biopsy even in patients with larger tumors post-neoadjuvant chemotherapy may be done safely and could eventually become another shift in our treatment paradigm. Brittany Harvey: Yes. The shared decision making is key as we think about these updates to improve quality of life and we'll await data from these ongoing trials to inform future updates to this guideline. So I want to thank you both so much for your extensive work to update this guideline and thank you for your time today. Dr. Park and Dr. Torres. Dr. Mylin Torres: Thank you. Dr. Ko Un "Clara" Park: Thank you. Brittany Harvey: And thank you to all of our listeners for tuning in to the ASCO Guidelines podcast. To read the full guideline, go to www.asco.org/breast-cancer-guidelines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines app available in the Apple App Store or the Google Play Store. If you have enjoyed what you've heard today, please rate and review the podcast and be sure to subscribe so you never miss an episode.   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  

Elon Musk continue d'explorer les frontières du possible avec Neuralink, l'une de ses nombreuses entreprises. Après son implant cérébral N1, conçu pour permettre aux personnes paralysées de contrôler un ordinateur par la pensée, il s'attaque désormais à la cécité avec son nouveau projet, Blindsight.L'objectif ? Redonner une forme de vision aux personnes totalement aveugles, à condition que leur cortex visuel soit intact. Blindsight fonctionne grâce à un réseau de microélectrodes implanté directement dans le cerveau. Ces capteurs stimulent les neurones en interprétant des images captées par une caméra externe. Selon Neuralink, cette technologie pourrait permettre aux patients de percevoir des formes et des objets, même si, dans un premier temps, la résolution resterait limitée. Elon Musk compare ce rendu aux graphismes rudimentaires des jeux Atari, mais promet une évolution vers une vision surpassant même l'œil humain, avec des capacités en infrarouge ou ultraviolet dignes d'un personnage de science-fiction.Le 30 mars, le milliardaire a annoncé que des tests sur des primates avaient donné des résultats encourageants, affirmant vouloir poser un premier implant sur un patient humain d'ici la fin de l'année. Mais cette annonce suscite autant d'enthousiasme que de scepticisme. Les essais de l'implant N1 sur des singes ont été critiqués pour leur manque d'éthique, et certains experts doutent de la viabilité scientifique de l'approche de Neuralink. Une étude de l'université de Washington souligne notamment que la technologie ne fonctionne pas comme prévu, les électrodes n'étant pas capables de générer des “pixels” de vision comme le suppose l'entreprise. Alors, révolution médicale ou illusion futuriste ? Si Neuralink parvient à prouver l'efficacité de son implant sur l'homme, cela marquera un tournant majeur. Mais pour l'instant, les promesses restent suspendues à des résultats concrets. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Þátturinn er í boði Maarud, Krónunnar, Fjarþjálfun.is, Happy Hydrate, N1 og Heimadecor.

About the Guest: Caroline Tracey is a distinguished writer focusing on topics related to art, literature, environment, and migration in the U.S., the Southwest, Mexico, and borderland regions. Caroline contributes to the Border Chronicle, among other reputable publications such as N1, The Nation, and The Guardian. Not only does she have expertise in English, but she is also trilingual, proficient in Spanish and Russian. Caroline's significant contributions to journalism include winning the 2019 Scoundrel Time Summer Literary Seminars nonfiction contest for her work on migrant deaths in South Texas. With a PhD in geography from UC Berkeley, Caroline is currently working on a book about salt lakes, set to be published by W.W. Norton. Episode Summary: In this episode of "90 Miles from Needles," host Chris Clarke converses with Caroline Tracey, a talented journalist with a focus on the borderlands of the U.S. and Mexico. The discussion revolves around Plan Sonora, a significant energy transition and development initiative in the Mexican state of Sonora, which borders the U.S. state of Arizona. Through this lens, Caroline explores the impacts of renewable and fossil fuel energy developments, such as lithium mining and solar arrays, on both local ecosystems and indigenous communities. Her insights underscore the complex balance between industrial progress and environmental conservation. The episode gives an in-depth look at Plan Sonora's four key components: a major solar array in Rocky Point, the nationalization of lithium mining reserves, an expansive natural gas pipeline project, and logistic developments that aim to transform Sonora into an economic hub. Caroline delves into activism efforts against these developments, particularly highlighting successful campaigns led by environmental groups against the Mexico Pacific's Saguaro Energy Project. By doing so, she paints a vivid picture of the current tensions between commercial ambitions and advocacy for ecological protection and cultural preservation. Key Takeaways: Plan Sonora: This encompasses solar power projects, lithium mining, natural gas pipeline proposals, and logistical developments, transforming Sonora into a critical player in renewable energy. Cross-border Impacts: Renewable energy developments in Mexico cater largely to U.S. demands, raising concerns about "green colonialism." Opposition and Activism: Indigenous communities and environmental activists are actively opposing certain projects due to cultural and environmental implications, most notably the pipeline and terminal proposals along the Gulf of California. Political Dynamics: Recent changes in Mexico's administration and judicial system reform are smoothing the way for energy investment and curtailing environmental regulations. Economic and Environmental Tensions: Despite opportunities for economic growth, critics argue these projects risk damaging vital ecosystems and stripping local communities of benefits. Notable Quotes: "Personally, I increasingly think that enlisting large corporations to do your climate mitigation work is inevitably going to kick you in the butt." - Chris Clarke "They plan to build a couple other solar plants that are of similar size…[in] the Gulf of California." - Caroline Tracey "There are four pipelines that are being developed right now…[raising] economic development to the detriment of people in Mexico." - Caroline Tracey "If indeed we're going to transition to renewable energy, that means first of all, stopping new extraction projects." - Caroline Tracey Resources: Caroline Tracey’s work at the Border Chronicle: https://www.theborderchronicle.com Caroline Tracey’s personal website: https://cetracey.com Ballenas ó Gas in Spanish: https://ballenasogas.org/ and in English: https://whalesorgas.org/ Article by By Martha Pskowski, Inside Climate News, and Alejandra Martinez, the Texas Tribune on opposition to the Saguaro Pipeline in Van Horn, TX: https://insideclimatenews.org/news/20122023/west-texans-rally-against-cross-border-pipeline/ Stay tuned to "90 Miles from Needles" for more enlightening discussions on desert protection and environmental advocacy.Become a desert defender!: https://90milesfromneedles.com/donateSee omnystudio.com/listener for privacy information.

In this deep dive episode, we look at how sleep onset can help creativity. With our amazing guest speakers, Professor Bob Stickgold, Dr Adam Horowitz, Professor Delphine Oudiette and Dr Celia Lacaux, we take a look at their work on creativity, dreams and N1 sleep. Together, we discuss different definitions of creativity, what defines N1 and what it is about N1 that makes it prime time for creative processing. Find out more about our guest speakers:Professor Bob StickgoldDr Adam HorowitzProfessor Delphine OudietteDr Celia LacauxPapers from the episode:Sleep onset is a creative sweetspot Replaying the Game: Hypnagogic Images in Normals and AmnesicsDormio: A targeted dream incubation deviceHost: Professor Penny LewisEditor: Sophie Smith Check out our NaPS website to find out more about our team, our research and events. This recording is the property of the Sleep Science Podcast and not for resale.

Þátturinn er í boði Maarud, N1, Krónunnar, Fjarþjálfun.is og Happy Hydrate.

Today, we sit down with Alex Bartell from Cinch I.T., a new Royal Oak Chamber member. Right away, Alex shares his unique talent for impressions, though he keeps them for in-person encounters—so if you see him at an event, be sure to ask! He also recounts a hilarious story of accidentally taking a ferry into Canada- you've got to hear this.Moving into business, Alex explains that Cinch I.T. is a franchise, started by his partner Josh Fett. Josh initially sought sales team members but ultimately realized he needed a business strategist. That's where Alex came in. Together, they've been working to expand the company by focusing on customer service first, believing that while technical skills can be taught, strong communication and problem-solving abilities set them apart.Speed is another key factor. The industry average for IT response time is four hours, but Cinch I.T. boasts an impressive 11-minute average over the last three years. Their ideal client ranges from 10 to 100 employees, where they can offer either full-service IT support or co-managed services alongside existing IT teams. Beyond troubleshooting, they emphasize consulting, ensuring that IT strategies align with business growth plans.Alex also shares ambitious goals for 2025, aiming to add 560 new users to their client base. The Chamber has already been a valuable resource, and he's enjoyed engaging with its networking groups like ROYAL (young professionals) and N1.For those interested in working with Alex and Cinch I.T., he's active on LinkedIn and can be reached directly at alex.bartel@cinchit.com. Learn more about the Royal Oak Chamber of Commerce: https://www.royaloakchamber.com/Connect with our hosts:Jon Gay from JAG in Detroit Podcasts - http://www.jagindetroit.com/Lisa Bibbee from Century 21 Northland - http://soldbylisab.com/

Þátturinn er í boði Maarud, N1, Krónunnar og Fjarþjálfun.is

There's a small but growing pothole on the N1, right next to the Woodmead on-ramp. It's been there for a year—unrepaired, ignored, and growing. How many cars will suffer damage before someone takes responsibility? Now, think about the pothole in your marriage. The cracks, the neglect, the silent damage—whose job is it to fix it? And more importantly, how long will you wait before it's too late?

Nakon uspješnog prošlog bojkota trgovina prehrambenim proizvodima koji je za 53 posto smanjio zaradu trgovcima na taj dan najavljuje se novi uz bojkotiranje tri određena trgovačka lanca. Uz potrošače i Vlada. Predsjednik Vlade ponovio danas ono što je ostalo u tajnosti nakon prvog sastanka s trgovcima i dobavljačima, no novinarima nije promakla ni imovinska kartica premijera koji ju je po hrvatskim zakonima dužan prijaviti. Saborska većina bi mogla ostati bez važnog glasa jer smijenjeni ministar Dabro koji se vratio u saborske klupe uvjetuje svoj glas smjenom šefa uprave Hrvatskih šuma. Nakon otpuštanja na privatnoj news televiziji N1 kreću otpuštanja i na hrvatskom javnom mediju. Rukometaši su nas oduševljavali na Svjetskom prvenstvu, do četvrtka navečer, a onda su nas doveli pred vrata raja.

Þátturinn er í boði N1 og Maarud.

Justin Bruce welcomes first-time guest Brendon Holland to recap the January 10 & 11, 2025 shows at Tree House Brewing Company in Deerfield, Massachusetts.Brendon is a professional videographer and recorded full videos of both shows and uploaded them to YouTube! N1 delivers a near-40 minute Figure It Out jam for the ages, and N2 garnered attention as the band infused a jammed-out Waiting Game with Phish's First Tube and elements of DWD and Chalkdust Torture.Thanks to Al W. for the crispy audience recordings used in the numerous jam clips scattered throughout this episode. Listen to his AUDs of N1 and N2 and peruse his catalogue of recordings on his Archive.org profile page.Vice or Virtue is a proud part of Osiris Media.Follow Vice or Virtue on InstagramFollow Justin Bruce on MastodonFollow Vice or Virtue on BlueskyEmail viceorvirtueaneggypod at gmail dot com Hosted on Acast. See acast.com/privacy for more information.

On redémarre cette année en douceur et en prenant soin de nous.Le boss et fondateur de Petit Bambou débarque sur tech 45', une très belle histoire tu vas voir, c'est aujourd'hui l'app de méditation N1 en France... et Europe ! Ludovic est très différent des entrepreneurs que tu as l'habitude d'entendre ici. → son parcours (il en est à sa 7ème entreprise)→ ses ambitions→ sa manière très originale de gérer sa teamLudovic a vraiment son style, perso je me suis régalé à l'interviewer, ça devrait te plaire, si c'est pas le cas, fais-le moi savoir, tu sais où me trouver, X ou LinkedIn je te réponds n'hésite pas. Ludovic a eu droit - comme tout le monde - au questionnaire tech 45', à savoir "meilleur et pire souvenir", " sa plus grosse erreur", "une anecdote jamais racontée en public" etc.Merci de ta fidélité à tech 45', ravi de commencer l'année avec toi, si tu aimes ce podcast, mets-moi le max d'étoiles sur Spotify ou Apple

V tokratnem Studiu ob 17.00 se bomo sprehodili skozi minulo leto v znanosti, tehnologiji, na področjih okolja in zdravja. V goste smo povabili štiri slovenske znanstvene novinarje, ki ta področja spremljajo vsak v svojem mediju in ki so lani spisali in v slovensko medijsko orbito poslali kar nekaj odmevnih medijskih zgodb. In čeprav so bili med snemanjem oddaje v mislih predvsem pri letu 2024, so ošvrknili tudi to, kaj bo v znanosti odmevalo letos. Gostje: Andreja Kutin, Večer; Staš Zgonik, N1; Nina Slaček,, Prvi program Radia Slovenija; Aljoša Masten, MMC RTV Slovenija.

V prvi Frekvenci X v novem letu se sprehajamo skozi preteklo leto v znanosti, tehnologiji, na področju okolja in zdravja. V goste je Maja Ratej povabila štiri novinarje, ki ta področja spremljajo vsak v svojem mediju in ki so lani v slovensko medijsko orbito poslali kar nekaj odmevnih zgodb. Kot se strinjajo, potrebuješ več truda, da ovržeš zavajajočo izjavo, kot pa ga terja njena stvaritev.Gostje: Andreja Kutin, Večer Staš Zgonik, N1 Nina Slaček, Prvi Aljoša Masten, MMC

Gleðilegt nýtt ár elsku fanbase! Hlökkum til að gefa út enn fleiri þætti og gera allskonar skemmtilegt með ykkur árið 2025.    Þátturinn er í boði Maarud, Natracare, N1 og Sign.

Today I chat with Noah, a missionary who began self-studying Japanese two years before landing in Japan in early '24. He promptly passed the JLPT N2, and is awaiting his results from taking N1 in December. Noah shares what worked for him, a surprisingly cheap and time efficient system that most missionaries (or any Japanese learners) could benefit from! Noah's suggested resources: Tofugu's resource page: https://www.tofugu.com/japanese-learn... Genki Textbook:   / 791506.genki_i   Minna No Nihongo textbook: https://www.goodreads.com/book/show/1... Jyoukyuu he no Tobira: https://tobiraweb.9640.jp/ A Dictionary of Intermediate Japanese Grammar: https://www.goodreads.com/book/show/9... Shin Kanzen Master Series: https://www.amazon.com/s?k=kanzen+mas... Anki flashcards (better on phone): https://ankiweb.net/shared/decks?sear... WaniKani: https://www.wanikani.com/ Podcasts for learning Japanese: Haru no Nihongo Learn Japanese With Noriko Yuyu no Nihongo

Justin Bruce welcomes Ryan Storm and Al W. back to the pod to discuss the band's late November co-headlining run at the Capitol Theatre in Port Chester, New York with Dogs in a Pile. Ryan wrote great reviews of N1 and N2 on his Substack page. This episode utilizes Al's audience recordings. Thank a taper! You can find all of his AUDs on his Archive.org profile page. Al's conversation begins around the 50 minute mark of this episode.Follow Vice or Virtue on InstagramFollow Justin Bruce on MastodonFollow Justin Bruce on BlueskyEmail viceorvirtueaneggypod at gmail dot com Hosted on Acast. See acast.com/privacy for more information.

U dvadesetoj epizodi “Radar Foruma”, izazivač Bojan Pajtić, profesor Pravnog fakulteta u Novom Sadu, ugostio je Danicu Vučenić, novinarku N1, koja je, kako je i sam domaćin istakao, decenijama sinonim za profesionalizam, integritet i borbu za istinu. Sagovornici su značajan deo razgovora posvetili (ne)slobodi medija u Srbiji, odgovornosti političara i suštinskim greškama prošlih i sadašnjih vlasti. Složili su se da je danas u Srbiji novinarstvo profesija sa ogromnim rizicima, ocenjujući da su upravo mediji ključni stub očuvanja režima Aleksandra Vučića, koji funkcionišu kao propagandna mašinerija obesmišljavajući kritičko razmišljanje i delovanje. Pajtić je postavio pitanje o neophodnosti lustracije, ne samo u političkim, već i u medijskim krugovima, kako bi se vratila profesionalnost i poverenje građana. Objasnio je da lustracija nije kazna, već način da se spreči povratak pojedinaca koji su urušavali demokratske principe. Vučenić je, s druge strane, podsetila na propuštene prilike Demokratske stranke da tokom svoje vlasti izgrade nezavisne institucije, naglašavajući da bi današnja opozicija trebalo da razume da slobodni novinari nisu saveznici nijednog režima. Razgovarali su i o studentskim blokadama koje se odvijaju širom Srbije, ocenjujući ih kao bunt, znak da još postoji energija za promene uprkos tome što je društvo sumnjalo u angažovanost mladih.

Have you ever snapped someone's head off simply because you are a sleepy head?  Our fuses can get pretty short when we're sleep deprived.  We need dream time therapy to hit reset on our emotions. And without it, look out. Sleep is so much more than rest. You and those around you can appreciate the benefits of good sleep on emotions and mood. Sleep is so much more than rest. You and those around you can appreciate the benefits of good sleep on emotions and mood. I'm Dr. Vickie Petz Kasper, I help you make changes that make a difference. Healthy Looks Great On You podcast takes you to mini medical school so you can learn the power of lifestyle medicine. Sleep is hard work. And I don't mean getting to sleep and staying asleep is hard work, though it often is. I mean, there's a lot of work that goes on while you sleep.  Sleep rebuilds your mental landscape. What happens when you sleep affects your emotions while you're awake. The brain undergoes active processing and healing while you're getting your Z's. You need sleep for emotional maintenance. The physiology is absolutely fascinating. So let's start right off the bat by going to mini medical school and learning about how sleep affects mood. Now, don't worry. I'll make it fun so you don't sleep through class.  Let's start with sleep cycle basics. There are two primary types of sleep that alternate in cycles throughout the night. And those are REM and non REM. That probably already sounds familiar. REM stands for rapid eye movement  and  they each have different functions. Non REM does the work of physical restoration and recovery, while REM does the emotional processing and cognitive maintenance. It's divided into three stages. Now this is going to be super easy to remember because the stages are called N1, N2, and N3. But let's peek under the covers and explore each of them a little more. Stage N1 is light sleep. And this is a transition between being asleep and being awake, and it only lasts about 5 or 10 minutes. In this stage, your muscle activity slows down, though you might twitch occasionally, and you can be easily awakened and even somewhat aware of your surroundings. You're actually asleep, but you're just in that lightest stage of sleep.  Stage N2 is moderate sleep, and this accounts for about 50 percent of total sleep time. During stage N2 sleep, your body cools down. The temperature actually gets lower, and your heart rate slows, and your brain waves slow down, and this is so important for memory consolidation. In fact, stage N2 sleep has a huge impact on your ability to learn, remember, and retain new information. The cognitive impact also includes decision making skills. Without adequate stage in to sleep, Memories don't get consolidated, and processing speed is slowed down, and so this causes increased difficulty with complex cognitive tasks. Lack of adequate sleep doesn't just affect your cognitive ability, though. It also affects mood. It makes us more susceptible to the effects of stress, both physically and emotionally. And emotionally.  Poor sleep disrupts emotional regulation, so we're more reactive.  The next time someone's voice goes up a couple of octaves in response to something you said, maybe, just maybe, They didn't sleep well last night.  I don't recommend mentioning it.  Even more serious than becoming a soprano during a conversation, without good sleep, people have an increased risk of mood disorders like depression and anxiety. And at the very least, the symptoms of anxiety are heightened without adequate shut eye. And listen, everyone reacts to having their buttons pushed, but when the work of sleep is on strike, our emotional resilience is kaput.   And the fruit of the spirit just goes right out the window. No peace, no patience, no kindness, no goodness, and definitely no gentleness.  Now, emotional reactions can be dangerous, but the physical health consequences of poor sleep can be deadly. Without good quality sleep, the immune system is weaker, metabolism is wrecked, Inflammation skyrockets and even hormones get out of whack. We need sleep for healing and recovery every single time the earth revolves around the sun. Think of your brain as a computer. You know, it has to be charged in order to function. Without recharging through sleep, there are several neurologic effects on your brain. Those grouchy neurons in your head quit communicating effectively. This leads to impaired synaptic plasticity. The dampening of the pathways in the brain to adapt and rewire themselves. It causes the brain to filter and organize information much less effectively. This leads to decreased productivity, more errors, and accidents. This process is crucial for emotional learning, adaptation, and developing resilience to emotional challenges. And don't we all have emotional challenges?  Stage N2 sleep is critical for overall cognitive and physical restoration. Chronic deficiency can lead to cumulative negative effects on mental and physical well being. Now before you put your head down on your desk for a little nap, Now, let's move on to the deepest subject, stage N3, or deep sleep. This one is essential for feeling refreshed. And here's the deal, you can't really skip over stage N1 and stage 2 to get there.  You can probably guess that this stage of deep sleep is the most restorative. It's harder to wake up during N3. It's so critical for physical recovery,  strengthening the immune system and promoting growth and repair of tissues.  You know how they always do road work at night? Well, your brain kind of does the same thing. And just like highway repair, it's never ending. Now, let's shift gears a little bit and talk about REM sleep. The brain undergoes a sophisticated process of emotional memory integration. And this just isn't passive storage, but it's an active recalibration of all of your emotional experiences.  And as implied by its name rapid eye movement. The eyes move rapidly beneath the eyelids and the brain is actually highly active, but the body is temporarily paralyzed.   This part of the sleep cycle is critical for cognitive functions like memory consolidation, emotional regulation, learning, and creative problem solving. I mean, have you ever woken up in the morning and just had a better perspective on things?   I certainly have. But while your eyes are dancing, your brain is sorting and processing emotional experiences. And this is what leads us to be more clear headed and in control of our emotions during the day. And without it, you're probably going to wind up on Santa's naughty list.  So, how does all this work? Well, that little maintenance crew in your brain goes to work in your prefrontal cortex. When the work of sleep is disrupted, emotional processing is impaired, which causes heightened emotional reactivity  and the reduced ability to manage stress.  No wonder we get irritable when we're sleep deprived.  Even more serious, during this phase of sleep, traumatic or intensely emotional memories are processed, and they're gradually detached from their immediate emotional intensity. So think about that. If they don't get detached, you just keep reliving it over and over with all of the emotional intensity attached.  That's miserable.  The brain essentially sorts out these emotional experiences and helps reduce their psychological impact. And that prevents us from being overwhelmed and it keeps us resilient.  Now that you understand how this neurochemical rebalancing of sleep has a direct impact on mood, Let's step into the lab for a sec and just look at a little bit of sleep chemistry. You see, sleep keeps neurotransmitters and hormones in balance to stabilize mood. Everybody's always worried about their hormones being out of balance. Well, how about trying a good night's sleep? Things like serotonin, the happy hormone, cortisol, the stress hormone, and dopamine, the motivating and pleasure hormone. All get regulated during sleep. What happens is, sleep replenishes the serotonin and dopamine while clearing out the excess cortisol.  When these neurochemicals are out of balance, due to poor sleep, there's more inflammation in the brain.   And that can increase anxiety and depressive symptoms. In fact, studies show that chronic sleepyheads are ten times more likely to experience symptoms of depression.  So, there's this little cleanup crew in the brain that's supposed to haul all of those inflammatory proteins to the dump. We call that the glymphatic system. But without good sleep at night,  they  don't get an opportunity to come in and clean up all those messes created during the day. As a result, there are more mood swings and more mood disorders. And here's the deal. It doesn't take a lot of sleep deprivation to cause a pile up. Even mild sleep deprivation can affect emotions. Just one night of poor sleep can increase negative emotional reactivity by up to 60%.    The bottom line is that sleep is so much more than rest. It's actually hard work. It's an active and very complex process coordinated by the amygdala. which is the brain's emotional processing center, as well as the prefrontal cortex, and that's where we make rational decisions. Or if we're sleep deprived, it's where we make irrational decisions.  The brain's nightly housekeeping crew, which occurs most effectively during deep sleep, helps maintain and restore emotional control. It's necessary to reset communication patterns, and reduce impulsive outbursts.    Think of it as a nightly emotional tune up for your brain, helping you process, adapt, and maintain psychological balance. And we all need balance, don't we? But like everything in life, this is no quick fix. Adults go through four to five complete sleep cycles every night, and each one of them lasts about 90 to 120 minutes. In other words, it takes some time to get there.  REM sleep tends to be shorter early on in the night and gets longer as the night goes on. It can last up to an hour. So, if you're feeling big feels that are out of proportion to the situation, take a look at your sleep quantity and quality.  Maybe your crankiness is a result of imbalance caused by lack of good sleep,  or depression, anxiety, or plain old stress that impacts sleep which interferes with that critical maintenance that goes on during shut eye.  Are you struggling with this area of your health?  If you have trouble with spinning thoughts that keep you from lying down in perfect peace, then grab a sleep freebie from my website.  This cheat sheet will help get you started turning off your mind so you can turn on restorative sleep. There's a link in the show notes or you can just head on over to my website www. healthylooksgreatonyou.com and look for the sleep freebie. If you want to feel rested, restored, and refreshed during the day, you need a good night's sleep.   It will help you feel in control of your emotions instead of them tricking you into making mountains out of molehills. Getting enough shut eye is crucial for your health, and healthy looks great on you.       RESOURCES: Cheat sheet to TURN OFF YOUR MIND AND TURN ON RESTORATIVE SLEEP Healthy Looks Great on You  Good food for good mood Move for better mood How alcohol, sugar and caffeine affect mood Navigating connections during the holidays From loneliness to belonging    

It's time for the Monthly Instagram Q&A. October 2024 edition. Notable questions our opinion on the volume and frequency recommendations, whether additional cardiovascular work can be beneficial to hypertrophy, and how to provide nutrition coaching for an entire 30 athlete football team. As always, a big thank you to the ETP community for providing us help on these episodes.TIMESTAMPS:00:00:36 - I haven't been able to gain strength in a long time. Been training for 15 years. If I want to keep getting Hypertrophy, is my only option to go bonkers on volume? 00:11:06 - Opinion on Chris b and Paul C vol & frequency recommendations. For example, a 4 day UL split in 7-day period vs PPL over say a 10 day period. Assume that 4 days was the most you could do in a normal week. 00:17:10 - How did you get into biking? I never learned how to ride growing up but just taught myself and am ready to start getting competitive!00:24:13 - What's better…. Overshooting or undershooting RPE?00:28:12 - Is the periodization model from N1 applicable for competitive Bodybuilders? 00:33:25 - What is Strakers plan to increase fertility for starting a family next year (or year after?)00:35:55 - How do you think your training will change in your 60's and 70's?00:41:33 - How to best ensure progress when you are using two different gyms with different types of equipment?00:44:40 - How to handle machines/benches being taken at commercial gym and exercise sequencing? Substitute, change exercise order, or wait it out?00:48:55 - What is a minimum and ideal amount of dietary fat to aim for?00:52:23 - When trying for fat loss, is it important to track 3 macros? I know some coaches only track protein and calories?00:56:07 - How to balance food diversity while also loving my same meals throughout the week?00:57:33 - How to target erectors under load with progressive overload?01:01:22 - Best meal 1-2 hours before cardio? Bryan's and Aaron's choice.01:03:36 - Do you think improving cardiovascular health will help with hypertrophy? https://pubmed.ncbi.nlm.nih.gov/23912805/01:07:10 - Are you guys taking on 1 on 1 clients? 01:08:46 - Hobbies outside of lifting? 01:10:46 - How would you design a program to achieve a Toes to Bar?01:12:41 - How would you manage the nutrition of a full football team 35 players that really knows nothing about nutrition? There's a huge room for improvement but how would you install this to this large team roster? Any ideas will be welcomed.01:18:02 - Thoughts on more aggressive deficits? Get “in and out” mentality versus being more conservative? Work 1:1 with Aaron ⬇️https://strakernutritionco.com/nutrition-coaching-apply-now/Done For You Client Check-In System for Coaches ⬇️https://strakernutritionco.com/macronutrient-reporting-check-in-template/Paragon Training Methods Programming ⬇️https://paragontrainingmethods.comFollow Bryan's Evolved Training Systems Programming ⬇️https://evolvedtrainingsystems.comFind Us on Social Media ⬇️IG | @Eat.Train.ProsperIG | @bryanboorsteinIG | @aaron_strakerYT | EAT TRAIN PROSPER PODCAST

日本是台灣人觀光旅遊最喜歡去的國家之一， 很多人從小就愛看日劇，也能說上幾句日文， 不過如果真的要會用日文，是一件困難的事嗎？ 日本女演員大久保麻梨子十幾年前來到台灣旅行深深愛上台灣， 隔年決定移居台北，從零開始學習中文， 2016年嫁給老公Jerry成為台灣媳婦， 台灣老公Jerry，更只花了1年的時間就考到日文檢定N1， 他來節目傳授自己學語言的秘訣方式， 究竟非本科系畢業的他，是怎麼培養日文腦，快速學好日文？ / 《大久保麻梨子的日文課》募資優惠中