Podcasts about Nautilus

  • 1,065PODCASTS
  • 2,085EPISODES
  • 47mAVG DURATION
  • 5WEEKLY NEW EPISODES
  • Jul 8, 2025LATEST
Nautilus

POPULARITY

20172018201920202021202220232024

Categories



Best podcasts about Nautilus

Show all podcasts related to nautilus

Latest podcast episodes about Nautilus

Word Balloon Comics Podcast
reviewing screens and streams Superman, Nautilus, Ironheart & More

Word Balloon Comics Podcast

Play Episode Listen Later Jul 8, 2025 112:35


This week on Word Balloon, it's a pop culture roundup as we dive into the latest film and TV buzz. From James Gunn's Superman reboot and the long-delayed Nautilus series finally surfacing, to the creepy Revival and the absurd action of FUBAR with Arnold Schwarzenegger—there's a lot to break down. We're also reviewing Marvel's Ironheart, discussing where it fits in the post-Wakanda Forever timeline,Jurasic World, and taking a pit stop to look at F1, the new racing film aiming to rev up the summer box office. Insight, laughs, and no punches pulled—this is the Word Balloon take on what's hot (and what's not) in the world of screens, big and small.

In Wheel Time - Cartalk Radio
From Savoy's Classic Cars to the Lincoln Nautilus's Modern Luxury

In Wheel Time - Cartalk Radio

Play Episode Listen Later Jul 8, 2025 28:49


A special In Wheel Time replay - Ever wandered through a museum where cars aren't just machines, but masterpieces? Mary Agrusa takes us inside the Savoy Auto Museum in Cartersville, Georgia, where vehicles are displayed with the reverence typically reserved for fine art. "We consider this really more an art museum dedicated to the automobile," Mary explains, and her passion for automotive history shines through as she guides us through exhibits that tell stories beyond horsepower and torque figures. Each vehicle comes with a reader board that doesn't just list specifications but delves into fascinating backstories—why a particular model succeeded or failed, its historical significance, or quirky facts about its design. Visitors can walk 360 degrees around most cars, appreciating them from every angle under specially designed lighting that showcases their sculptural qualities. From an untouched 1925 Model T about to celebrate its 100th birthday to the elegant lineup of Studebakers charting the company's evolution, the museum offers something for casual visitors and dedicated enthusiasts alike.The Savoy isn't just preserving automotive history; it's inspiring the next generation. After their 1959 Plymouth Savoy named "Beatrice" participated in the Great Race (before unfortunately dropping two cylinders in West Virginia's mountains), local schools were inspired to build their own race cars for future competitions. This hands-on approach to automotive education perfectly complements the museum's mission to make car culture accessible and engaging for everyone.Switching from classic to contemporary, Don Armstrong takes us behind the wheel of the 2025 Lincoln Nautilus, and his enthusiasm is immediate. With its door-to-door digital display spanning the entire dashboard, this midsize SUV redefines interior luxury. Assembled in Hangzhou, China, the Nautilus combines elegant exterior styling with a smooth turbocharged powertrain that achieves impressive fuel economy. As Don puts it, "It gets an A-plus for attractiveness," positioning it as a standout option in a competitive segment that includes the Mercedes-Benz GLC and Genesis GV70.Whether yoBe sure to subscribe for more In Wheel Time Car Talk!The Lupe' Tortilla RestaurantsLupe Tortilla in Katy, Texas Gulf Coast Auto ShieldPaint protection, tint, and more!Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.---- ----- Want more In Wheel Time car talk any time? In Wheel Time is now available on Audacy! Just go to Audacy.com/InWheelTime where ever you are.----- -----Be sure to subscribe on your favorite podcast provider for the next episode of In Wheel Time Podcast and check out our live multiplatform broadcast every Saturday, 10a - 12noonCT simulcasting on Audacy, YouTube, Facebook, Twitter, Twitch and InWheelTime.com.In Wheel Time Podcast can be heard on you mobile device from providers such as:Apple Podcasts, Amazon Music Podcast, Spotify, SiriusXM Podcast, iHeartRadio podcast, TuneIn + Alexa, Podcast Addict, Castro, Castbox, YouTube Podcast and more on your mobile device.Follow InWheelTime.com for the latest updates!Twitter: https://twitter.com/InWheelTimeInstagram: https://www.instagram.com/inwheeltime/https://www.youtube.com/inwheeltimehttps://www.Facebook.com/InWheelTimeFor more information about In Wheel Time Car Talk, email us at info@inwheeltime.comTags: In Wheel Time, automotive car talk show, car talk, Live car talk show, In Wheel Time Car Talk

Pop Break TV
TV Break: July 2025 - Reviews of Ironheart, The Bear, Demon Slayer, Smoke + Why is Neil Druckmann Out at The Last of Us?

Pop Break TV

Play Episode Listen Later Jul 7, 2025 74:34


Welcome to TV Break, where Pop Break's Podcasts Editor Alex Marcus is joined by editor-in-chief Bill Bodkin, and TV Columnist Josh Sarnecky to talk about the happenings in television.Here's the format of the show:The Best Thing I Saw on TV Last Month – Alex, Bill, & Josh talk about a show/episode/event they liked from the last month including Hulu's The Bear, Disney Plus's Ironheart, and crunchyroll's Demon Slayer, andAMC's Nautilus.Newsbreak – This month, they discuss shocking news that the mind behind The Last of Us, Neil Druckmann, will be leaving the HBO series to focus on a new game, Intergalactic: The Heretic Prophet, which is currently in development. The guys also review the backlash around the divisive second season of the series and wonder how much that controversy informed Neil's decision.Streaming Wars – Alex, Bill, & Josh pick a streamer they think “won the month” based on new shows airing/upcoming shows announced etc. This month, everyone backed a different streamer, with Josh giving props to Netflix on the back of its breakthrough Korean content Squid Game and KPop Demon Hunters, as well as strong returning numbers for Ginny & Georgia and Quarterback.Meanwhile, Bill gave some love to Peacock on the strength of viral hit Love Island USA, and Alex gave it to Apple TV Plus after their box office success with F1: The Movie and the recent news that Jennifer Aniston would be starring in and co-showrunning for an adaptation of the hit memoir I'm Glad My Mom Died.New Series Spotlight – This month we are shining the spotlight on Apple TV Plus's fire crime drama Smoke. This series stars Taron Egerton as a local arson investigator on the hunt for not one but two serial arsonists and Jurnee Smollett as a metro detective who is called in to assist his stagnant investigation. Safe Spall, Greg Kinnear, and John Leguizamo also star. The series was created by acclaimed crime novelist Dennis Lehane, based on the podcast Firebug, about arsonist John Leonard Orr, and is directed by The Falcon and The Winter Soldier director Kari Skogland.

Comic News Insider
Episode 1622 - Interrupting w/ Reviews!

Comic News Insider

Play Episode Listen Later Jul 6, 2025 43:43


Reviews: Iron Heart s1, Lazarus s1, Nautilus s1 premiere, Squid Game s3, The Walking Dead: Dead City s2, Elio, How to Train Your Dragon, Jurassic World Rebirth, KPop Demon Hunters, The Old Guard 2, 28 Years Later We interrupt this Heroes Con coverage with a review catch up! Jimmy watches A LOT of shows & films and brings you his thoughts on it all. Did the Squid Game finale satisfy? Is the rage virus still scary 28 years later? Does KPop Demon Hunters deserve all the hype? Tune in to find out! Come back later this week and the next few weeks to hear all of the Heroes Con interviews.  Also, get a hold of us! Thanks for listening!

Moments with Marianne
The Logoharp with Arielle Emmett, PhD

Moments with Marianne

Play Episode Listen Later Jul 3, 2025 26:50


What would it take to reclaim your voice when every word is being scripted for you? This dystopian novel asks unsettling questions about love, loyalty, and the price of obedience in a world where no one lives past 50. Tune in for an inspiring discussion with Arielle Emmett, PhD, on her Nautilus award-winning novel The Logoharp: A Cyborg Novel of China and America in the Year 2121.  Moments with Marianne airs in the Southern California area on KMET 1490AM & 98.1 FM, an ABC Talk News Radio Affiliate!  https://www.kmet1490am.com  Arielle Emmett, PhD, is a writer and science journalist specializing in East Asia, Africa, and cross- cultural interactions. She was a Contributing Editor to Smithsonian Air & Space magazine (2014-2021) and a Fulbright Scholar and Specialist in Kenya (2018-2019) and Indonesia (2015). A Mandarin and French speaker, Emmett has won prizes in magazine and journal competitions staged by the American Society of Journalists and Authors (ASJA) and the International Communications Association (ICA). She has reported and taught in China and Hong Kong, Taiwan, Indonesia, East Africa, Ireland, and Italy. Currently, she lives in North Carolina and travels frequently to see her three clever grandchildren. Emmett's debut novel is the first in a planned series on dystopian paths to utopian justice. https://leapingtigerpress.com Order The Logoharp on Amazon: https://a.co/d/2J1Ot8A  For more show information visit: www.MariannePestana.com

Investor Fuel Real Estate Investing Mastermind - Audio Version
From Novice to Expert: Thriving in Midwest Real Estate

Investor Fuel Real Estate Investing Mastermind - Audio Version

Play Episode Listen Later Jul 1, 2025 33:59


In this conversation, Stephen Schmidt interviews Carter Olles, co-founder of Nautilus, a private equity firm focused on acquiring multifamily properties in the Midwest. Carter shares his journey into real estate, the unique opportunities he sees in the Midwest market, and the strategies Nautilus employs to ensure high-quality investments. The discussion covers the importance of thorough due diligence, understanding market dynamics, and the long-term vision for Nautilus, emphasizing the need to prioritize investor interests and manage risks effectively. Professional Real Estate Investors - How we can help you: Investor Fuel Mastermind:  Learn more about the Investor Fuel Mastermind, including 100% deal financing, massive discounts from vendors and sponsors you're already using, our world class community of over 150 members, and SO much more here: http://www.investorfuel.com/apply   Investor Machine Marketing Partnership:  Are you looking for consistent, high quality lead generation? Investor Machine is America's #1 lead generation service professional investors. Investor Machine provides true ‘white glove' support to help you build the perfect marketing plan, then we'll execute it for you…talking and working together on an ongoing basis to help you hit YOUR goals! Learn more here: http://www.investormachine.com   Coaching with Mike Hambright:  Interested in 1 on 1 coaching with Mike Hambright? Mike coaches entrepreneurs looking to level up, build coaching or service based businesses (Mike runs multiple 7 and 8 figure a year businesses), building a coaching program and more. Learn more here: https://investorfuel.com/coachingwithmike   Attend a Vacation/Mastermind Retreat with Mike Hambright: Interested in joining a “mini-mastermind” with Mike and his private clients on an upcoming “Retreat”, either at locations like Cabo San Lucas, Napa, Park City ski trip, Yellowstone, or even at Mike's East Texas “Big H Ranch”? Learn more here: http://www.investorfuel.com/retreat   Property Insurance: Join the largest and most investor friendly property insurance provider in 2 minutes. Free to join, and insure all your flips and rentals within minutes! There is NO easier insurance provider on the planet (turn insurance on or off in 1 minute without talking to anyone!), and there's no 15-30% agent mark up through this platform!  Register here: https://myinvestorinsurance.com/   New Real Estate Investors - How we can work together: Investor Fuel Club (Coaching and Deal Partner Community): Looking to kickstart your real estate investing career? Join our one of a kind Coaching Community, Investor Fuel Club, where you'll get trained by some of the best real estate investors in America, and partner with them on deals! You don't need $ for deals…we'll partner with you and hold your hand along the way! Learn More here: http://www.investorfuel.com/club   —--------------------

Moments with Marianne
Journey of the Broken Vessels with Dr. Ashten Duncan

Moments with Marianne

Play Episode Listen Later Jul 1, 2025 21:17


What happens when a young doctor, seeking purpose and healing, finds himself in a town where every relationship, and every choice, feels predestined? Tune in for an inspiring discussion with Ashten Duncan on his Nautilus award-winning novel Journey of the Broken Vessels.  Moments with Marianne airs in the Southern California area on KMET 1490AM & 98.1 FM, an ABC Talk News Radio Affiliate!  https://www.kmet1490am.com  Ashten Duncan, MD, MPH, CPH, is a Native American writer, board-certified family physician, and researcher originally from Oklahoma. He holds a Bachelor of Science in Microbiology, Master of Public Health, and Doctor of Medicine from the University of Oklahoma. He completed his postgraduate medical training in the University of New Mexico - Santa Fe Family Medicine Residency Program.   He has authored dozens of research articles, essays, op-eds, poems, short stories, monographs, and other pieces in publications like Scientific American. He has edited for medical humanities journals and online publications and has served as a peer reviewer for many academic journals. Residing in northern New Mexico with his wife, Dr. Duncan serves as core faculty for a rural family medicine residency program at a federally qualified health center. Journey of the Broken Vessels is his first novel. https://www.ashtenduncanwriting.comOrder Journey of the Broken Vessels: https://a.co/d/c8vnFqr For more show information visit: www.MariannePestana.com

Moments with Marianne
The Generous Leader with Joe Davis

Moments with Marianne

Play Episode Listen Later Jul 1, 2025 26:23


Is it possible to lead with heart in a high-performance workplace, and still win? Tune in for an inspiring discussion with Joe Davis on his Nautilus award-winning book The Generous Leader: 7 Ways to Give of Yourself for Everyone's Gain.  Moments with Marianne airs in the Southern California area on KMET 1490AM & 98.1 FM, an ABC Talk News Radio Affiliate!  https://www.kmet1490am.comJoe Davis served as Managing Director and Senior Partner at BCG. In The Generous Leader, Joe shares a performance review: He was told he was not the best at problem-solving solo; but with others, he could solve any challenge. His manager identified his key strength - a person who could connect. Joe spent 37 years with BCG, co-founded the Washington DC office, led office systems, started BCG's NA Public Sector business, led BCG North America, founded and chaired BCG's Center for Inclusion and Equity. Joe earned his BA from Whitman College, and his MBA from HBS. Joe is currently serving his second term as Whitman's Board Chair.  https://www.joedavis.comOrder The Generous Leader here: https://a.co/d/2xXzlRAFor more show information visit: www.MariannePestana.com

T.Kell Knives Live! Life, Liberty and the Pursuit of Knives
☕️ LIVE FROM THE BUNKER – Blade Drops, GAW Madness, and Final Pen Reveal!

T.Kell Knives Live! Life, Liberty and the Pursuit of Knives

Play Episode Listen Later Jun 30, 2025 123:14


Fresh coffee's brewing thanks to Eli, and we're going live at 10AM EST on YouTube for another raw, real, and rowdy Sunday in the bunker. Here's what's on deck:     •    Huge stack of blades nearing completion or never-before-seen     •    Final sneak peek of the exclusive pen collab before it launches     •    Massive GAWs—we're giving away a ton of gear today     •    Gifts from the TKellian community we can't wait to share     •    Production updates, including Nautilus and DP-1 shipping progress This is a big one—tons of blades, tons of giveaways, and the best damn crew in the game.

freie-radios.net (Radio Freies Sender Kombinat, Hamburg (FSK))
Franz Jung und die Technik des Glücks – eine Lesung mit den Schauspielern Jörg Pohl und Lars Rudolph und der Mitgründerin des Nautilus Verlags Hanna Mittelstädt (Serie 198: Lorettas Leselampe)

freie-radios.net (Radio Freies Sender Kombinat, Hamburg (FSK))

Play Episode Listen Later Jun 30, 2025 31:39


Mitschnitt einer szenischen Lesung im Nachtasyl des Thalia-Theaters, aufgeführt am 22. November 2024 Der Titel des Abends: Franz Jung und die Technik des Glücks – eine Lesung mit den Schauspielern Jörg Pohl und Lars Rudolph und der Mitgründerin des Nautilus Verlags Hanna Mittelstädt

Regras do Jogo - Holodeck
Análise Comuna #001 – Paradise Killer

Regras do Jogo - Holodeck

Play Episode Listen Later Jun 27, 2025 114:54


Ficamos felizes em apresentar o Análise Comuna, um novo programa do Holodeck Design focado em análises de jogos por uma perspectiva radical de esquerda. Neste programa, abordamos diferentes jogos, investigando o tipo de discurso político presente neles, trazendo discussões sobre economia política, crítica cultural e estética. Teremos também a presença de convidados especiais que irão enriquecer e contribuir na conversa. No primeiro episódio, falamos do cult classic Paradise Killer, um jogo de aventura desenvolvido pela Kaizen Game Works onde os jogadores assumem o papel de Lady Love Dies, uma investigadora que é trazida do exílio e encarregada de descobrir o culpado de um assassinato em massa em Paradise Island. Para conversar sobre sacrificios de sangue, utopias e distopias, corpos sarados e o deserto do real, recebemos novamente Henrique Antero, jornalista e membro do Nautilus. Ajude a financiar o Holodeck Design no Apoia.se e Orelo.cc ou fazendo doações pelo PicPay. Siga o Holodeck Design no Twitter, Facebook, Instagram e TikTok e entre no grupo para ouvintes do Telegram! Nossos episódios são gravados ao vivo em nosso canal na Twitch e YouTube, faça parte também da conversa. Participantes Fernando Henrique Anderson do Patrocínio Henrique Antero Cupons de Desconto regrasdojogo – 10% Descontos em todas as camisas da Veste Esquerda. Músicas: Paradise Killer OST

Outcomes Rocket
A New Healthcare Economy Is Emerging Outside Carrier Networks

Outcomes Rocket

Play Episode Listen Later Jun 26, 2025 25:43


This podcast is brought to you by Outcomes Rocket, your exclusive healthcare marketing agency. Learn how to accelerate your growth by going to⁠ outcomesrocket.com Open-sourcing healthcare contracting and data infrastructure can unlock massive cost savings while improving outcomes. In this episode, Dave Chase, board president of Nautilus Health Institute and founder of Health Rosetta, dives into the major shift happening in employer-sponsored healthcare. He explains why he gave away $4 million worth of intellectual property to launch Nautilus, with the goal of decentralizing control from entrenched incumbents and empowering employers. Thousands of organizations are now using these models to achieve consistent 20–50% cost reductions while improving care quality, aided by real-time claims data and predictive analytics. Dave also shares his collaboration with Mark Cuban to release hospital contracts and tells inspiring stories, like how one Alabama manufacturer used healthcare savings to fund employee scholarships, illustrating the rise of a “healthcare ownership economy.” Tune in and learn how open-source tools, data access, and local innovation are rewriting the rules of employer health benefits in America! Resources: Connect with and follow Dave Chase on LinkedIn. Follow Health Rosetta on LinkedIn and explore their website. Learn more about Nautilus Health Institute here. Listen to Dave's previous interview on the podcast here! Buy Dave's book Relocalizing Health here. Find out more about this year's RosettaFest here. Register for this year's RosettaFest here

Equity Foundation Podcast
Casting Director Dave Newman in Conversation with Sharon Johal

Equity Foundation Podcast

Play Episode Listen Later Jun 26, 2025 60:20


Equity's Live Stream Program continues with esteemed casting director Dave Newman, of McSweeney Newman Casting, talking to actor Sharon Johal about all things auditions, casting, current and past projects, the actor/casting director relationship and answering all your questions. McSweeney Newman Casting cover Australia and New Zealand for international and local projects. Credits Include: Blacklight, Love and Monsters, Dora and the Lost City of Gold, Nautilus, Darby & Joan, The Castaways, No Escape - The Blue, Rock Island Mysteries, The Family Law, Australia Day, The Inbetweeners 2, Mako Mermaids, The Pacific & East West 101

Moments with Marianne
The Young Green Witchs Guide to Plant Magic with Robin Rose Bennett

Moments with Marianne

Play Episode Listen Later Jun 24, 2025 23:56


Have you ever felt like nature was trying to tell you something? What if you learned how to listen? Tune in for an inspiring discussion with Robin Rose Bennett on her Nautilus award-winning book The Young Green Witch's Guide to Plant Magic: Rituals and Recipes from Nature.  Moments with Marianne airs in the Southern California area on KMET 1490AM & 98.1 FM, an ABC Talk News Radio Affiliate! https://www.kmet1490am.comRobin Rose Bennett is a story-teller, writer, and herbalist, offering classes in Herbal Medicine and EarthSpirit Teachings since 1986 - at herb conferences, festivals, medical schools, and most joyously, outside with the plants. Robin Rose shares herbal medicine with gratitude for the loving generosity of the plants and the magic, mystery, and beauty of the web of life. She is the author of: Healing Magic: A Green Witch Guidebook to Conscious Living, The Gift of Healing Herbs: Plant Medicines and Home Remedies for a Vibrantly Healthy Life,  A Young Green Witch's Guide to Plant Magic: Rituals and Recipes from Nature (2025 Nautilus Silver Award Winner), and A Green Witch's Pocket Book of Wisdom: Big Little Life Tips.   https://www.robinrosebennett.comOrder the The Young Green Witch's Guide to Plant Magic here: https://a.co/d/ckwHtEOFor more show information visit: www.MariannePestana.com

TV Tan Podcast
TV Tan 0539: The Tight Lotus

TV Tan Podcast

Play Episode Listen Later Jun 23, 2025 55:37


Bill Frost (CityWeekly.net, X96 Radio From Hell) and Tommy Milagro (SlamWrestling.net) talk Ironheart, The Bear, Countdown, My Mom Jayne, Smoke, Squid Game, Nautilus, Stick, Murderbot, Duster, Adults, Rasslin' News, The Walking Dead: Dead City, Jimmy Kimmel's Live summer guest hosts, Sinners on HBO Max July 4, FUBAR, Vin Diesel on The Studio, The White Lotus porn parody: The Tight Lotus, The Nickelodeon Kids' Choice Awards, the unlikely return of Digman!, and more.Drinking: Sir-Veza Mexican Lager from OFFICIAL TV Tan sponsor Bohemian Brewery.* Yell at us (or order a TV Tan T-shirt) @TVTanPodcast on Threads, Bluesky, Facebook, Instagram, or Gmail.* Rate us: Spotify, Apple Podcasts, YouTube Music, YouTube, Amazon Podcasts, Audible, etc. 

Moments with Marianne
New Body, Old Soul with Terri Harford

Moments with Marianne

Play Episode Listen Later Jun 23, 2025 27:12


What if the key to understanding your life today was hidden in a past-life you've already lived? Tune in for an inspiring discussion with Terri Harford on her Nautilus award-winning book New Body, Old Soul: A Modern Mystics Guide to Spiritual Empowerment in the Age of AI.  Moments with Marianne airs in the Southern California area on KMET 1490AM & 98.1 FM, an ABC Talk News Radio Affiliate! https://www.kmet1490am.comTerri Harford is an existential psychologist, soul coach, and author of the Nautilus award-winning book New Body, Old Soul, a powerful exploration of consciousness, karma, and spiritual transformation. With a BA in Fine Art from the University of Cape Town and a BA (Hons) in Psychology from UNISA, Terri blends her artistic insight with psychological depth to guide others on the path of self-realization. Drawing from over two decades of meditative practice, shadow work, and soul inquiry, she bridges the realms of physics and spirituality to illuminate the deeper purpose behind existence. Based along South Africa's Garden Route, Terri lives in harmony with nature's rhythms, nurturing a sacred bond with the land and a community of like-minded seekers devoted to spiritual awakening. https://terriharford.co.zaOrder New Body, Old Soul on Amazon here: https://a.co/d/8NVVDFSFor more show information visit: www.MariannePestana.com

Moments with Marianne
Mahina Rises with John Blossom

Moments with Marianne

Play Episode Listen Later Jun 22, 2025 25:27


Can the spirit of Aloha hold the key to overcoming fear, loss, and even climate change? Tune in for an inspiring discussion with John Blossom on his Nautilus award-winning novel Mahina Rises.Moments with Marianne airs in the Southern California area on KMET 1490AM & 98.1 FM, an ABC Talk News Radio Affiliate! https://www.kmet1490am.comJohn Blossom is an award-winning author and lifelong educator whose work explores the spiritual and environmental challenges of modern culture. With over 25 years of teaching experience in independent schools across the U.S. and Hawaii, John brings a deep understanding of human development and cultural storytelling to his books which span a variety of genres. He holds a BA in English (Magna Cum Laude) from Carleton College, a BFA in Ceramics (Highest Honors) from Sierra Nevada College, and an MAT (Honors in Writing) from Colorado College. Currently living on The Island of Hawaii, John continues to write novels that blend magical realism, ancestral wisdom, and ecological themes, as seen in his Nautilus Award-winning novel, Mahina Rises.https://www.jtblossom.comOrder Mahina Rises on Amazon: https://a.co/d/cFGV1DkFor more show information visit: www.MariannePestana.com

Moments with Marianne
Our Worst Strength with Dr. James F. Richardson

Moments with Marianne

Play Episode Listen Later Jun 22, 2025 33:28


Why is it so hard to make and keep close friendships in modern America, and what does that reveal about us? Tune in for an inspiring discussion with Dr. James F. Richardson on his new Nautilus award-winning book Our Worst Strength: American Individualism and its Hidden Discontents. Moments with Marianne airs in the Southern California area on KMET 1490AM & 98.1 FM, an ABC Talk News Radio Affiliate!  https://www.kmet1490am.comJames F. Richardson is a PhD, cultural anthropologist who has studied American society for twenty years as a market research consultant.  Recently, the author of a new, award-winning nonfiction book, Our Worst Strength: American Individualism and Its Hidden Discontents, questioning our approach to individualism as a way of life. He lives in Tucson, Arizona, where he writes a weekly Substack — Homo Imaginari — for a growing international readership.https://substack.com/@jamesrichardsonOrder Our Worst Strength on Amazon: https://a.co/d/gCVPxrm For more show information visit: www.MariannePestana.com

Moments with Marianne
Stolen Voices with Bonnie Bley

Moments with Marianne

Play Episode Listen Later Jun 20, 2025 18:26


Why are so many Indigenous women and girls going missing in America, and why isn't anyone talking about it? Tune in for an inspiring discussion with Bonnie Bley on her Nautilus award-winning book Stolen Voices: Missing and Murdered in Big Horn County. Moments with Marianne airs in the Southern California area on KMET 1490AM & 98.1 FM, an ABC Talk News Radio Affiliate!  https://www.kmet1490am.comBonnie Bley is an award-winning author whose work explores identity, place, and justice in the American West. Born in Wyoming and raised in Hardin, Montana—a border reservation town in the southeastern corner of the state—her formative years deeply shaped her storytelling and commitment to advocacy.  Her academic journey took her to South Dakota and Minnesota, where she sharpened her research and writing skills. Since the late 1980s, she has called Minnesota home, though her creative and emotional connections to Montana and Wyoming remain at the heart of her work. In Stolen Voices: Missing and Murdered in Big Horn County, Bley brings to light the stories of Indigenous people who have tragically gone missing or been murdered in the very county where she grew up. Through intimate interviews, investigative research, and gripping storytelling, she offers a deeply personal and urgent account of a national crisis too often ignored. Passionate about advocacy and community service, Bley also volunteers with Big Brothers Big Sisters, The Wildcat Sanctuary, and Feed My Starving Children. Her work amplifies voices that deserve to be heard while striving to inspire awareness and change. https://www.bonniebley.com/index.htmlOrder Stolen Voices on Amazon: https://a.co/d/eM58MkvFor more show information visit: www.MariannePestana.com

Moments with Marianne
Boys with Roger Newman

Moments with Marianne

Play Episode Listen Later Jun 20, 2025 23:40


Brotherhood is more than skin-deep. After Alex's family is killed by the Ku Klux Klan during the Great Depression, he takes refuge in the barn of a nearby dairy farm. The family that owns the dairy, including their young son Pete, take in Alex and raise the boys together. Pete and Alex consider themselves brothers and together they navigate the Jim Crow racial intolerance of the rural South. Tune in for an inspiring discussion with Roger Newman on his Nautilus award-winning book Boys: A Novel, based on a true story.  Moments with Marianne airs in the Southern California area on KMET 1490AM & 98.1 FM, an ABC Talk News Radio Affiliate!  https://www.kmet1490am.comIn addition to Boys which is based on a true story, Roger Newman is the author of a series of medical thrillers: Occam's Razor, Two Drifters, and What Becomes; and a Civil War historical fiction novel Will O' the Wisp: Madness, War, and Recompense. He is a professor of obstetrics and gynecology, specializing in the care of women with multiple gestations. He has authored two hundred scientific papers, a dozen book chapters, and the award-winning and bestselling When You're Expecting Twins, Triplets, or Quads; Fourth Edition. He served as the national president for the Society forMaternal-Fetal Medicine and has been voted by his peers as one of the “Best Doctors in America” for thirty consecutive years. He and his wife, Diane, live on the Ashley River in Charleston, South Carolina. https://rogerbnewman.com Order Boys on Amazon: https://a.co/d/9exs9vCFor more show information visit: www.MariannePestana.com

Moments with Marianne
Bugs in My Tummy with Alana C. Marks

Moments with Marianne

Play Episode Listen Later Jun 20, 2025 20:13


Could one children's book spark lifelong healthy habits in your child? Tune in for an inspiring discussion with Alana C. Marks on her Nautilus award-winning children's book Bugs in My Tummy.Moments with Marianne airs in the Southern California area on KMET 1490AM & 98.1 FM, an ABC Talk News Radio Affiliate!  https://www.kmet1490am.comAlana C. Marks discovered a love of writing as an adolescent when she began writing a pen pal. One pen pal soon grew to a multitude as her letters spread to friends near and far. When her children were born, her nightly story telling talents blossomed and from that ritual her first novel, Unbroken Bones, was born.  Writing is Alana's hobby which she does in her spare time between managing her business and traveling abroad. She's a sucker for a quiet walk or bike ride down a lonely forest trail, which always seems to soothe her soul and ignite her imagination.  https://www.alanacmarks.comBugs in My Tummy on Amazon: https://a.co/d/5aRW2aH For more show information visit: www.MariannePestana.com

Drip Podcast
INFLUENCES #107 w/ Coba

Drip Podcast

Play Episode Listen Later Jun 19, 2025 108:14


1. Bobby Lyle Trio - ナイト・ブリーズ 2. Buzz - Garasumado 3. ASHFORD & SIMPSON - Love It Away 4. Sarah Vaughan - Inner City Blues 5. Maynard Ferguson - Mister Mellow 5. Lalo Schifrin - Danube Incident 6. Fujimaru Band - Paper Machine 7. Koji Kobayashi - Bokura no Date 8. Marcos Valle, Leon Ware - Feels So Good 9. Nautilus feat. Ryuto Kasahara - What You Won't Do For Love 10. Carlos Dafé - Zicartola 11. Cortex - La rue 12. Mike Longo - Matrix 13. Ronnie Foster - Night Life 14. Willie Wright - Right On For The Darkness 15. Gil Scott-Heron And Brian Jackson - It's Your World 16. Tim Maia - 3 Em 1 17. Another Taste - Anything You Want 18. Groove Collective - Hide It 19. Herb Geller - Sudden Senility2 (Vocal Version) 20. David Matthews & The Electric Birds - Media 21. People's Choice - You Ought To Be Dancin' 22. Mandrill - Disco Lypso 23. Cameo - Cameosis 24. MFSB - Summertime And I'm Feelin' Mellow 25. Millie Jackson - I'm Free

Baleine sous Gravillon (BSG)
SPÉCIAL Céphalopodes 1/4 : Y'a un os... ou pas ? L'album de famille (PPDP)

Baleine sous Gravillon (BSG)

Play Episode Listen Later Jun 15, 2025 9:38


Cet épisode est une rediffusion de Petit Poisson deviendra Podcast. Avec Combats et Nomen, PPDP est l'un des 4 petits frères de Baleine sous Gravillon. Nous diffusons cette série Céphalopodes du petit frangin chez le grand à l'occasion de la journée mondiale de l'océan, le 8 juin de chaque année._______On connaît tous la Pieuvre, mais qu'en est-il du Nautile ou de l'Argonaute ? La classification des Céphalopodes est pleine de surprises et de tentacules.“Céphalopode” désigne une classe de mollusques marins regroupant les différentes espèces de Poulpes, Seiches, Calmars, Nautiles… Elles sont caractérisées par des bras attachés à la tête, selon l'espèce elles peuvent avoir de 8 à plus de… 90 bras !Saviez-vous que les noms “Pieuvre” et “Poulpe” désignent les mêmes animaux ? C'est Victor Hugo qui a popularisé le terme Pieuvre, en l'utilisant dans son livre Les Travailleurs de la mer paru en 1866. Ce nom était utilisé par des pêcheurs de Guernesey.La classe des Céphalopodes comprend 3 sous classes, les Ammonites (éteintes depuis 66 millions d'années), les Nautiloïdes (les Nautiles) et les Coléoïformes (l'immense majorité). Ces derniers n'ont pas de coquille externe mais certains ont une structure interne rigide. Les Seiches ont un sépion et les Calmars une plume. Enfin les Poulpes n'ont rien de rigide, à part leur bec.Les espèces de ce taxon vivent dans tous les océans du monde et même dans des conditions extrêmes. La Pieuvre dumbo se déplace dans les abysses alors que Vulcanoctopus hydrothermalis vit près des volcans sous-marins.Les Poulpes ont 9 cerveaux ! Chacun de leurs 8 bras contient un système nerveux périphérique.Du Kraken, au sous-marin Nautilus du Capitaine Némo, en passant par la gastronomie, les Céphalopodes nourrissent l'imaginaire et la culture.______

Choses à Savoir
Pourquoi le point Nemo est-il l'endroit le plus inaccessible de la Terre ?

Choses à Savoir

Play Episode Listen Later Jun 12, 2025 2:08


Avez-vous déjà entendu parler du point Nemo ? C'est un endroit unique sur notre planète. Un lieu dont on dit qu'il est le plus isolé du monde. Mais où se trouve-t-il exactement, et pourquoi fascine-t-il autant ?Le point Nemo est ce qu'on appelle le pôle d'inaccessibilité océanique. En d'autres termes, c'est le point de l'océan le plus éloigné de toute terre émergée. Il se situe dans le sud de l'océan Pacifique, à environ 2 688 kilomètres des trois terres les plus proches : l'île Ducie (au nord), l'île Motu Nui, qui fait partie des îles de Pâques (au nord-est), et l'île Maher, en Antarctique (au sud).Ce point a été calculé pour la première fois en 1992 par un ingénieur croate, Hrvoje Lukatela, à l'aide de modèles informatiques et de coordonnées GPS. Il se trouve aux environs de la latitude 48°52.6′ Sud et de la longitude 123°23.6′ Ouest.Son nom, "Nemo", est bien sûr un clin d'œil au célèbre capitaine du Nautilus dans le roman de Jules Verne "Vingt mille lieues sous les mers". En latin, "nemo" signifie d'ailleurs… "personne". Un nom parfaitement approprié pour ce lieu si reculé.Ce qui rend le point Nemo fascinant, c'est son isolement extrême. Aucune île habitée à l'horizon. Pas de routes maritimes commerciales. Aucun survol régulier d'avion. Si vous vous trouviez là, les humains les plus proches seraient probablement… les astronautes à bord de la Station spatiale internationale, qui passe parfois à seulement 400 km au-dessus de ce point, bien plus près que n'importe quel continent.Le point Nemo est aussi devenu une zone de "cimetière spatial". Depuis les années 1970, les agences spatiales, dont la NASA ou Roscosmos, y font tomber en fin de vie leurs satellites, sondes ou stations spatiales, comme ce fut le cas pour la station MIR en 2001. Pourquoi là ? Justement parce que c'est une zone quasi déserte, minimisant les risques pour les populations et la navigation.Sur le plan biologique, les eaux autour du point Nemo sont très pauvres en vie marine : peu de nutriments, peu de lumière, peu de courant. Un véritable désert aquatique.En résumé, le point Nemo est une sorte de bout du monde maritime. Une curiosité géographique, un symbole de solitude absolue sur Terre — et une petite touche de science-fiction quand on pense que ce sont les astronautes, depuis l'espace, qui peuvent être ses visiteurs les plus proches. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Moments with Marianne
This Fresh Existence with Cindy Rasicot

Moments with Marianne

Play Episode Listen Later Jun 11, 2025 29:25


What happens when one woman dares to challenge centuries of religious tradition, not with protest, but with compassion, wisdom, and an unwavering heart? Tune in for an inspiring discussion with Cindy Rasicot on her Nautilus award-winning book This Fresh Existence: Heart Teachings from Bhikkhuni Dhammananda. Moments with Marianne airs in the Southern California area on KMET 1490AM & 98.1 FM, an ABC Talk News Radio Affiliate!  https://www.kmet1490am.comCindy Rasicot is a retired psychotherapist and author of This Fresh Existence: Heart Teachings from Bhikkhuni Dhammananda, a Nautilus Gold and Special Honors: Ordained to Lead: Women's Spiritual Legacy Award. In 2005 she travelled to Thailand with her family where she met Bhikkhuni Dhammananda — an encounter that changed her life forever. In 2020 she wrote the award winning memoir Finding Venerable Mother: A Daughter's Spiritual Quest to Thailand. Her memoir is a soulful story of spiritual healing through her loving connection with Bhikkhuni Dhammananda. The book was a finalist in the international Book awards, The Sarton Awards, and Chanticleer International Book Awards. https://cindyrasicot.comAmazon: https://a.co/d/bIVLwcpFor more show information visit:www.MariannePestana.com

Moments with Marianne
The Magic of Yes with Lori Pappas

Moments with Marianne

Play Episode Listen Later Jun 11, 2025 27:26


What if everything you've been through was actually preparing you to become the woman you were always meant to be?  Tune in for an inspiring discussion with Lori Pappas on her Nautilus award-winning book The Magic of Yes: Embrace the Wise Woman Within.Moments with Marianne airs in the Southern California area on KMET1490AM & 98.1 FM, an ABC Talk News Radio affiliate!  https://www.kmet1490am.comLori Pappas was one of the first female computer sales reps in the world in her 20s; an award-winning entrepreneur in her 30s and 40s, and, after failing retirement, founded an international charity and moved to Africa in her 50s. At 67, she met the “love of her life” online, and at 75, Lori launched her next career with her award-winning book, The Magic of Yes: Embrace the Wise Woman Within. Lori leveraged her experience with successful business models to create an innovative D.R.E.A.M. framework, The Magic of Yes includes practical strategies for personal growth and self-care, empowerment tools for leadership and success in business, and most importantly, tips for how you can access your inner wisdom in everyday life.  https://www.loripappas.com The Magic of Yes on Amazon: https://a.co/d/cLJvIJVFor more show information visit: www.MariannePestana.com

Moments with Marianne
Fifty-seven Fridays with Myra Sack

Moments with Marianne

Play Episode Listen Later Jun 8, 2025 29:44


What does it mean to celebrate life in the face of profound loss, and how can that act transform not only grief, but those who witness it? Tune in for an inspiring discussion with Myra Sack on her new book Fifty-Seven Fridays: Losing Our Daughter, Finding Our Way.Moments with Marianne airs in the Southern California area on KMET1490AM & 98.1 FM, an ABC Talk News Radio affiliate!  https://www.kmet1490am.comMyra Sack is the author of Nautilus award-winning memoir, "Fifty-Seven Fridays: Losing Our Daughter Finding Our Way," and founder of E-Motion, Inc., a nonprofit organization created to support community, movement and ritual to enhance coping and resilience. Myra's life changed when her older daughter, Havi, died on January 20, 2021 of Tay-Sachs disease. Myra is a certified Compassionate Bereavement Care provider, holds an MBA in Social Impact from Boston University, and graduated with a B.A. cum laude from Dartmouth College. Myra's writing has been featured in the Boston Globe, Kveller, People, Hadassah Magazine, Today and Upworthy. Myra serves on the Board of the Courageous Parents Network and  lives in Boston, MA with her family. https://www.myrasack.com https://www.emotion-mc.orgFor more show information visit: www.MariannePestana.com

Wrist Check Podcast
How To Get A Patek Philippe Watch, Insiders Tips From An Authorized Dealer | WCP Weekly

Wrist Check Podcast

Play Episode Listen Later Jun 4, 2025 66:51


In this insider-packed episode of Wrist Check Podcast, Rashawn and Perri pull back the curtain on one of the most elusive questions in watch collecting: How do you get a Patek Philippe from an authorized dealer? They break down the mysterious allocation process, explain why being a family-owned brand shapes how Patek operates, and offer real talk on what the application process actually looks like. From building a long-term relationship to expressing genuine interest in the brand beyond the Nautilus and Aquanaut, this episode is essential listening for anyone serious about entering the world of Patek.Powered by @getbezel Shop 20,000+ watches at getbezel.com, and Download the Bezel app at download.getbezel.com⁠⁠⁠SUBSCRIBE⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to get the latest Wrist Check Pod content ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow us on instagram⁠⁠Chapters01:04 - Intro02:26 - Rashawn Wrist Check04:13 - Perri Wrist Check08:30 - The Ideal Patek Collector12:39 - Aligning yourself with the brand16:27 - Deciding where to shop20:11 - What Patek Values23:18 - How do I get a Nautilus28:12 - Patek wants to know you intimately30:07 - Resellers31:49 - Family Owned Business35:01 - Entry into Patek37:44 - Its an expensive game42:34 - Getting into application pieces46:10 - Navigating clients51:05 - Why are Pateks trading under retail54:04 - What does Patek offer clients01:00:01 - Is it advantageous to collect Patek solely01:02:33 - Outro

Disney Klassiekers, een podcast van Robin Broos
149. 20.000 Leagues Under the Sea (1954) - Ralf Verhoef

Disney Klassiekers, een podcast van Robin Broos

Play Episode Listen Later Jun 4, 2025 67:37


Na Michiel Veenstra mag Ralf Verhoef - ook één derde van de Nederlandse Disney-podcast D-Tales - eens aanschuiven. Dit voorjaar kon ik nog met hen meegaan op groepsreis naar de drie Aziatische Disney Resorts. Dat blijkt een meerwaarde voor deze aflevering: we hebben het over een oude familiefilm, maar wel eentje met een stevige voetafdruk in zowel ‘onze' Disneyland Paris als in Tokyo DisneySea. De boot Nautilus uit Jules Verne's ‘20.000 Leagues Under the Sea' heeft een plekje in Discoveryland in Parijs en zelfs een heel gebied Mysterious Island ofte Vulcania in Tokio. We hebben het over de vrouwen van Kirk Douglas, over Imagineer Harper Goff die de spectaculaire decors bouwde en over de pax media's die Walt Disney sloot om deze peperdure film te kunnen draaien. Maar het gaat ook over atoomenergie, over de dandy in Kapitein Nemo en waarom Douglas hier zo hard op Popeye lijkt. Verder wijken we graag uit over de eventuele uitbreidingen van het Disneyland Park in Parijs, de Society of Explorers and Adventurers en uiteraard de Aziatische parken. Got a whale of a tale to tell ya, lads!

Eat Train Prosper
Pre Steroid-Era Training Protocols - Part Two #ETP191

Eat Train Prosper

Play Episode Listen Later Jun 3, 2025 71:08


In Part 2 of Pre Steroid-Era Training Protocols, we keep the pre-steroid era lens on but bring it forward—pulling lessons from the past into how you can fine-tune your “now.” Rep schemes, recovery, fatigue management, and why progression models likely still need a bit of human touch. Wrapping up with the introduction of Arthur Jones' Nautilus machines, and romanticizing the minimalist, burly, barbell garage Dad. Episode Timestamps:00:00 Introduction to Part 204:06 Bryan's Training Experiment: Full Body Approach10:12 Aaron's Upcoming Show and Dieting Insights16:08 Exploring Historical Training Styles22:58 Rep Schemes and Training Volume25:51 Failure, Effort, and Auto-Regulation in Training33:58 Managing Fatigue: Different Approaches36:46 Exploring Recovery and Progression Models39:53 Understanding Linear Progression and Its Variants43:38 The Evolution of Training Methods: From Volume to Isolation48:24 The Impact of Historical Training Routines51:40 The Nautilus Revolution in Strength Training01:00:00 Romanticizing the Basics: The Blue Collar Approach to Training01:04:04 Reflections on the Golden Era of Bodybuilding Work 1:1 with Aaron ⬇️https://strakernutritionco.com/nutrition-coaching-apply-now/Done For You Client Check-In System for Coaches ⬇️https://strakernutritionco.com/macronutrient-reporting-check-in-template/Paragon Training Methods Programming ⬇️https://paragontrainingmethods.comFollow Bryan's Evolved Training Systems Programming ⬇️https://evolvedtrainingsystems.comFind Us on Social Media ⬇️IG | @Eat.Train.ProsperIG | @bryanboorsteinIG | @aaron_strakerYT | EAT TRAIN PROSPER PODCAST

Fitness M/K
#068 Fitness-historien v. Kasper Lund Kirkegaard (3/3)

Fitness M/K

Play Episode Listen Later May 29, 2025 55:05


Vi har haft besøg af Kasper Lund Kirkegaard til endnu en udsendelse om fitness'ens historie. I den sidste udsendelse nåede vi kun op til 80'erne hvor Jørgen Albrechtsen startede Nautilus. Kort efter kom cardio træningen og holdtræningen ind i motionscentrene, først i form af Aerobic og siden hen med Spinning, hvor Charlotte Bircow var instrumental i udbredelsen deraf. I 90'erne var der også den første krise i fitness branchen, hvor de to største kæder krakkede. Endelig ser vi i 90'erne også hvordan SATS og fitnessDK starter, førstnævnte i røven på konkursen af det amerikanske fitnesskæde koncept 24hour fitness. Dét hjælper Kasper os med at fortælle historierne bag.NB: Programmet er et genudgivet program fra da Fitness M/K blev Produceret hos Radio24syv. Programmet blev sendt første gang 2016-11-12. "Hejsa, det er din vært, Anders her.Hvis du gerne vil følge bedre med i hvad der sker i Fitness M/K universet, så kan du nu blive skrevet op til vores nyhedsbrev. Der vil du på månedsbasis modtage nyheder om podcasten, som nye afsnit, kommende events, tilbud fra og samarbejder med podcast gæster.Du kan blive skrevet op til nyhedsbrevet her , læse nyt fra redaktionen her, se og søge afsnit her.Jeg håber at se dig i Fitness M/K universet på www."

Tomos y Grapas, Cómics
Moonshine | All In Superman | Nautilus | Space Mullet | Los Zazous | The Walking Cat | NOVEDADES

Tomos y Grapas, Cómics

Play Episode Listen Later May 28, 2025 130:32


Os dejamos nuestro repaso semanal de novedades y recomendaciones para que tengáis la pila de lecturas siempre ocupada y al día. All In Superman El Asombroso Spiderman Las 8 Muertes de Spiderman Vengadores Costa Oeste The Walking Cat Space Mullet Moonshine Los Zazous. Swing contra los nazis Nautilus Détox Saint Seiya The Lost Canvas Marvel Must-Have - Hulk: Hulk Rojo All In Green Arrow All In Green Lantern

Ràdio Arrels
Nostre Mar, un festival mediterrani i compromès - Jérôme Vilacèque

Ràdio Arrels

Play Episode Listen Later May 28, 2025 6:05


Nostre Mar, és un festival cultural mediterrani i un festival polític antiracista. Més enllà de ser un projecte ciutadà iniciat en 2022 a Perpinyà amb l'objectiu de presentar una visió contemporània i plural de la Mediterrània, aquest festival assumeix un combat cultural important. Proposa una immersió en la diversitat d'espais, de possibilitats, d'arts, tot defensant activament l'amistat entre els pobles mediterranis i lluitant contra els racismes, l'antisemitisme, l'odi anti-LGBTIQ+ i el sexisme. El festival proposa una programació variada i rica amb cinema, música, conferències...Per descobrir tot el que fa la particularitat de Nostre Mar, hem entrevistat el Jérôme Vilacèque, fundador del Nautilus que acull una gran part dels esdeveniments del festival.Nostre Mar és un festival SOS Racisme.

MotherChip - Overloadr
MotherChip #525 - Doom: The Dark Ages e Fantasy Life i: The Girl Who Steals Time

MotherChip - Overloadr

Play Episode Listen Later May 21, 2025 82:53


Neste episódio temos mais uma vez a companhia de Lucas Zavadil, do Nautilus. A gente conversou do mais recente Doom, Doom: The Dark Ages, que colocou um escudo nas mãos do Doomslayer e fez algumas mais outras mudanças interessantes à fórmula. Além dele, Lucas traz o novo Fantasy Life, Fatansy Life i: The Girl Who Steals Time, que o encantou com seu constante charme.Participantes:Lucas ZavadilHeitor De PaolaAssuntos abordados:00:00 - Doom: The Dark Ages51:00 - Fantasy Life i: The Girl Who Steals TimeVai comprar jogos na Nuuvem? Use o link de afiliado do Overloadr!Use nosso link de filiado ao fazer compras na Amazon Hosted on Acast. See acast.com/privacy for more information.

The Generation Why Podcast
Kim Wall - 624

The Generation Why Podcast

Play Episode Listen Later May 19, 2025 42:52


Renowned journalist Kim Wall boarded Nautilus, the homemade, private submarine of Peter Madsen, near Copenhagen, Denmark, on the evening of August 10, 2017. The following morning, the submarine was spotted before it suddenly sank. Only Madsen was rescued by the search and rescue team. What happened to Kim Wall?For bonus episodes and outtakes visit: patreon.com/generationwhyListen ad free with Wondery+. Join Wondery+ for exclusives, binges, early access, and ad free listening. Available in the Wondery App. https://wondery.app.link/generationwhy.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Historical Perspectives on STEM
Psychedelics in America

Historical Perspectives on STEM

Play Episode Listen Later May 16, 2025 82:27


In this episode of Perspectives, we speak with Benjamin Breen and Jonathan Moreno on the history of psychedelic drugs in America. There is a resurgence of interest in psychedelics in the medical world as possible treatments for conditions such as depression, anxiety, and PTSD. This resurgence comes after a period during which psychedelic drugs were thought to be dangerous and have no medical value. An earlier perception was more optimistic. Figures such as Margaret Meade and Timothy Leary looked to drugs like peyote and LSD to allay fears, provide insights, broaden cultural perspectives and lead to chemical enlightenment. As mainstream institutions take yet another look, join us to examine the changing legal, medical and cultural perspectives on psychedelic drugs. Benjamin Breen is Associate Professor of history at the University of California, Santa Cruz. His second book is Tripping on Utopia: Margaret Meade, the Cold War and the Troubled Birth of Psychedelic Science. In addition to his academic publications, his writing has appeared in the The Washington Post, Paris Review Daily, The Atlantic, Slate, Aeon, The Pacific Standard, The Chronicle of Higher Education, The Public Domain Review, Nautilus, and Lapham's Quarterly. Jonathan Moreno is the David and Lyn Silfen University Professor Emeritus at University of Pennsylvania, where he works on bioethics, health policy, and the history and sociology of biology and medicine. He is the author of six books and numerous academic papers, and his work as also appeared in the New York Times, Wall Street Journal, Science, Nature, Slate, Politico, The Hill and Foreign Affairs. For more information on this and other topics, please see https://www.chstm.org/video/77474 Recorded on December 10, 2024.

In Wheel Time - Cartalk Radio
The Savoy Museum blends automobile history with artistic presentation while Lincoln delivers luxury with the 2025 Nautilus.

In Wheel Time - Cartalk Radio

Play Episode Listen Later May 8, 2025 28:49


Automotive artistry takes center stage as we visit Georgia's Savoy Auto Museum with curator Mary Agrusa. Unlike typical car museums focusing solely on mechanics, the Savoy presents vehicles as cultural artifacts for artistic appreciation, complete with historical storytelling.Mary reveals how Cartersville has become Georgia's "museum city" with four major institutions. The Savoy Museum itself features display techniques allowing 360-degree viewing with lighting that showcases each vehicle's design elegance. The museum's approach to interpretation, where each car's technical specs mix with historical significance, and often surprising backstories—like the unrestored 1925 Model T purchased under the strict condition it would never be restored, preserving its authentic century-old character.The Savoy connects with its community, including partnerships with local schools to encourage students to participate in prestigious events like the Great Race, fostering a new generation of automotive enthusiasts. Whether you're planning a road trip through the Southeast or seeking a destination with multiple attractions, Cartersville's museum quarter offers something for everyone.The second half of our show features a review of the 2025 Lincoln Nautilus, with its revolutionary door-to-door digital display and luxury exterior styling. This midsize luxury SUV delivers comfort to compete with rivals from Mercedes-Benz, Genesis, and Acura. Excellent fuel economy and a smooth, sophisticated driving experience, the Nautilus represents Lincoln's return to the luxury segment.Ready for your next automotive adventure? Tune in for our upcoming broadcast from the Lone Star Street Rod Association State Run in Granbury, Texas on June 12th—bringing you more fascinating stories from America's diverse car culture.Be sure to subscribe for more In Wheel Time Car Talk!The Lupe' Tortilla RestaurantsLupe Tortilla in Katy, Texas Gulf Coast Auto ShieldPaint protection, tint, and more!Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.---- ----- Want more In Wheel Time car talk any time? In Wheel Time is now available on Audacy! Just go to Audacy.com/InWheelTime where ever you are.----- -----Be sure to subscribe on your favorite podcast provider for the next episode of In Wheel Time Podcast and check out our live multiplatform broadcast every Saturday, 10a - 12noonCT simulcasting on Audacy, YouTube, Facebook, Twitter, Twitch and InWheelTime.com.In Wheel Time Podcast can be heard on you mobile device from providers such as:Apple Podcasts, Amazon Music Podcast, Spotify, SiriusXM Podcast, iHeartRadio podcast, TuneIn + Alexa, Podcast Addict, Castro, Castbox, YouTube Podcast and more on your mobile device.Follow InWheelTime.com for the latest updates!Twitter: https://twitter.com/InWheelTimeInstagram: https://www.instagram.com/inwheeltime/https://www.youtube.com/inwheeltimehttps://www.Facebook.com/InWheelTimeFor more information about In Wheel Time Car Talk, email us at info@inwheeltime.comTags: In Wheel Time, automotive car talk show, car talk, Live car talk show, In Wheel Time Car Talk

In Wheel Time - Cartalk Radio
The 2025 Lincoln Nautilus, VW Amarok, and the Ford Ranger!

In Wheel Time - Cartalk Radio

Play Episode Listen Later May 7, 2025 14:36


Slip behind the wheel of luxury as we explore the redesigned 2025 Lincoln Nautilus, a midsize SUV that's redefining automotive elegance. From the moment you lay eyes on its symmetrical wheel openings and sophisticated body sculpting to the Black Label grille adorned with chrome star-like dots, this vehicle demands attention for all the right reasons.The true revelation happens inside the cabin, where Lincoln has implemented a revolutionary door-to-door digital display that spans the entire dashboard. This stunning technological achievement, paired with adjustable massage seating and premium materials throughout, creates an interior experience that left our reviewers speechless. Despite being assembled in Hangzhou, China, the Nautilus maintains its distinctly American luxury character with a smooth, comfortable ride that makes every journey a pleasure.Powered by a capable 2-liter turbocharged 4-cylinder delivering 250 horsepower and 280 pound-feet of torque, the Nautilus balances performance with efficiency, achieving 25.5 mpg during our testing. Starting at $51,790, it positions itself against competitors like the Mercedes-Benz GLC, Genesis GV70, and Acura RDX, offering a distinctive alternative in the luxury SUV landscape.We also dive into the fascinating world of global automotive partnerships, exploring how Ford and Volkswagen's collaboration has yielded the impressive Amarok pickup, built on the Ford Ranger platform with 7,700 pounds of towing capacity. Our review of the Ford Ranger Lariat 4x4 reveals how today's midsize trucks now match the dimensions and capabilities of what used to be considered full-size pickups just decades ago. Subscribe to our podcast for more insightful automotive reviews and discussions about the rapidly evolving vehicle landscape!Be sure to subscribe for more In Wheel Time Car Talk!---- ----- Want more In Wheel Time car talk any time? In Wheel Time is now available on Audacy! Just go to Audacy.com/InWheelTime where ever you are.----- -----Be sure to subscribe on your favorite podcast provider for the next episode of In Wheel Time Podcast and check out our live multiplatform broadcast every Saturday, 10a - 12noonCT simulcasting on Audacy, YouTube, Facebook, Twitter, Twitch and InWheelTime.com.In Wheel Time Podcast can be heard on you mobile device from providers such as:Apple Podcasts, Amazon Music Podcast, Spotify, SiriusXM Podcast, iHeartRadio podcast, TuneIn + Alexa, Podcast Addict, Castro, Castbox, YouTube Podcast and more on your mobile device.Follow InWheelTime.com for the latest updates!Twitter: https://twitter.com/InWheelTimeInstagram: https://www.instagram.com/inwheeltime/https://www.youtube.com/inwheeltimehttps://www.Facebook.com/InWheelTimeFor more information about In Wheel Time Car Talk, email us at info@inwheeltime.comTags: In Wheel Time, automotive car talk show, car talk, Live car talk show, In Wheel Time Car Talk

Murder, Mystery & Mayhem Laced with Morality
Cheryl Grey Bostrom—Pacific Northwest Author Captures Mystery & Wonder In Her Award-Winning Fiction

Murder, Mystery & Mayhem Laced with Morality

Play Episode Listen Later May 4, 2025 39:15


A keen student of the natural world and the workings of the human heart, Pacific Northwest author Cheryl Grey Bostrom captures the mystery and wonder of both in her lyrical, riveting fiction. Her novels Sugar Birds (Christy finalist, Amazon bestseller, and Book of the Year) and Leaning on Air have won more than two dozen industry honors, among which are CT's Fiction Award of Merit and American Fiction, Reader's Favorite, ACFW Carol, Nautilus, Best Book, Foreword Indies, and International Book Awards.An avid birder and nature photographer, Cheryl lives in rural Washington State with her husband and three irrepressible Gordon setters.Make sure to check out this author on Instagram @cherylgreybostrom

Section_86
Twice Upon a Time S06E15 “A Wondrous Place”

Section_86

Play Episode Listen Later May 4, 2025 60:07


At a loss for hope, Regina suggests a “girls’ night out” for Emma with her and Snow. While at the bar, she confides in the mixologist and sheds a tear. Meanwhile, the Nautilus is transported to the Enchanted Forest, where Aladdin and Jasmine board. They have yet to locate Agrabah and are growing weary. After […]

Epicenter - Learn about Blockchain, Ethereum, Bitcoin and Distributed Technologies
Mysten Labs: How Sui Leverages Move to Build the Composable Web3nternet - Adeniyi Abiodun

Epicenter - Learn about Blockchain, Ethereum, Bitcoin and Distributed Technologies

Play Episode Listen Later Apr 29, 2025 63:09


Founded by former Meta Diem team members, Sui is a high-performance, layer-1 blockchain designed for horizontal scaling and low-latency transactions. It uses an object-centric data model and the Move programming language to enable transaction parallelization which can handle >200,000 txs/s. Sui's goal is to combine the benefits of blockchains with Web2's security & frictionless UX. From account abstraction & ZKLogin, to on-chain storage & data availability solutions like Walrus, Sui rebuilds the Google/AWS stack, fully on-chain and composable.Topics covered in this episode:Adeniyi's background, from Libra to SuiSui's long-term visionThe tech stack of Sui & its primitivesZKLogin & account abstractionObject-based approachTransaction processing & parallelizationDevEx on Move vs. EVM vs. SVMConsensus & scalabilityMEVGaming & SuiPlayDeFi on SuiWalrus data storageNautilusFuture roadmapEpisode links:Adeniyi Abiodun on XMysten Labs on XSui on XWalrus on XSponsors:Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.ioChorus One: one of the largest node operators worldwide, trusted by 175,000+ accounts across more than 60 networks, Chorus One combines institutional-grade security with the highest yields at - chorus.oneThis episode is hosted by Brian Fabian Crain.

From The Green Notebook
Mastering Your Emotions with Dr. Lisa Feldman Barrett

From The Green Notebook

Play Episode Listen Later Apr 17, 2025 72:43


Send us a textIn this episode, Joe sits down with Dr. Lisa Feldman Barrett, a leading neuroscientist and author of How Emotions Are Made, to explore groundbreaking insights on how emotions are formed and how we can better understand and regulate them. Together, they dive deep into the science behind emotions, how the brain predicts our feelings, and how we can gain more emotional agency in our personal and professional lives. Joe and Dr. Barrett cover:The theory of constructed emotions and how emotions are predictions, not reactionsThe role of the brain in regulating the body and how it shapes emotional experiencesWhy uncertainty feels like anxiety—and how to reframe itHow emotional granularity can help us build better emotional vocabulary and controlPractical steps to improve emotional regulation and decision-makingThe impact of body budgeting on mood, stress, and overall healthWhether you're leading a team, navigating personal relationships, or simply trying to better understand your emotional life, this conversation will give you powerful tools to enhance your emotional intelligence and well-being.Lisa Feldman Barrett, PhD, is among the top 0.1% most cited scientists in the world for her revolutionary research in psychology and neuroscience. She is a University Distinguished Professor of Psychology at Northeastern University. She also holds appointments at Harvard Medical School and Massachusetts General Hospital, where she is Chief Science Officer for the Center for Law, Brain & Behavior.In addition to the books Seven and a Half Lessons About the Brain and How Emotions are Made, Dr. Barrett has published over 275 peer-reviewed, scientific papers appearing in Science, Nature Neuroscience, and other top journals in psychology and cognitive neuroscience, as well as six academic volumes published by Guilford Press. She writes regularly about science in the popular press, including The New York Times, The Guardian, Scientific American, BBC Science Focus, Popular Science, Nautilus, BigThink, Cosmopolitan,  Time magazine, MIT Technology Review, and more (see full list). Her popular TED talk has been viewed over 7 million times.A Special Thanks to Our Sponsors!Veteran-founded Adyton. Step into the next generation of equipment management with Log-E by Adyton. Whether you are doing monthly inventories or preparing for deployment, Log-E is your pocket property book, giving real-time visibility into equipment status and mission readiness. Learn more about how Log-E can revolutionize your property tracking process here!Meet ROGER Bank—a modern, digital bank built for military members, by military members. With early payday, no fees, high-yield accounts, and real support, it's banking that gets you. Funds are FDIC insured through Citizens Bank of Edmond, so you can bank with confidence and peace of mind. Visit

Park Views With Brad Hughes
Living with the Jedi Talk - Ryan Street joins the show

Park Views With Brad Hughes

Play Episode Listen Later Apr 17, 2025 51:21


This week while Evan has handcuffed himself to the Nautilus at Tokyo Disney, we welcomed host of iamgeek podcast and Living with the Landspeeder podcast...Ryan Street!  Hear about the kyber crystals he creates and sells, which are absolutely amazing! We played a mini game where we were randomly given a Disney World attraction and Star Wars theme we had to reimagine the ride to.  It was a lot of fun!  @jeditalkpodcast on IG YouTube.com/JediTalk @iamgeekshow on IG

Translating Proteomics
Intro to Proteomics

Translating Proteomics

Play Episode Listen Later Apr 16, 2025 14:45


On this special episode of Translating Proteomics, Parag and Andreas break down the basics of proteomics — perfect for anyone with a background in molecular biology looking to get started in the field.Seasoned experts: We hope you can share this episode as a teaching tool or to inspire others to explore proteomics.Parag and Andreas cover the following questions in the episode, and links to additional Nautilus resources can be found below each question.What is proteomics?Blog post – What is proteomics? Techniques, applications, and methodsWhat are key questions proteomics can answer?Blog category – Applications of proteomicsWhy is it important to measure the proteome?FAQ on the Nautilus Resources pageBlog post – Genomics vs. proteomics: Two complementary perspectives on lifeWhat can and can't you do with proteomics?Translating Proteomics episode – Plasma Proteomics: The Dream and the NightmareLearn how the Nautilus Platform is designed to enable comprehensive broadscale proteomics and targeted proteoform studiesWhat are key proteomics methods and techniques?Blog series – Traditional protein analysis methodsBlog series – Next-generation proteomics technologiesWhat are the major pitfalls when doing proteomics?What are the challenges in proteomic data analysis?Translating Proteomics episode – Biology in Space and TimeBlog post – What is multiomics?What are people excited about in proteomics?Translating Proteomics episode – Poised for a Proteomics BreakthroughTranslating Proteomics episode - US HUPO 2025 – Key Takeaways, Trends, and Future Directions for ProteomicsTranslating Proteomics episode –

DJ Ian Head Mixes and Podcasts
Pullin from the Stacks - Another Stack of Jazz 45s

DJ Ian Head Mixes and Podcasts

Play Episode Listen Later Apr 10, 2025 33:50


Went back to the "Jazz 45s" box and pulled a few things out that I hadn't played in awhile. Spring is here and it felt right. A short set of selections, new and old - enjoy! Tracklist: Sam Hankins, Eric Kloss, Nautilus, Quincy Jones, Charles Mingus, Takumi Moriya, Phi-Psonics, Unknown artist, Eddie Harris, Jukka Eskola Trio, Mary Lou Williams

ASCO Guidelines Podcast Series
Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer Guideline Update

ASCO Guidelines Podcast Series

Play Episode Listen Later Apr 10, 2025 20:51


Dr. Ko Un “Clara” Park and Dr. Mylin Torres present the latest evidence-based changes to the SLNB in early-stage breast cancer guideline. They discuss the practice-changing trials that led to the updated recommendations and topics such as when SLNB can be omitted, when ALND is indicated, radiation and systemic treatment decisions after SLNB omission, and the role of SLNB in special circumstances. We discuss the importance of shared decision-making and other ongoing and future de-escalation trials that will expand knowledge in this space. Read the full guideline update, “Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer: ASCO Guideline Update” at www.asco.org/breast-cancer-guidelines. TRANSCRIPT This guideline, clinical tools, and resources are available at http://www.asco.org/breast-cancer-guidelines. Read the full text of the guideline and review authors' disclosures of potential conflicts of interest in the Journal of Clinical Oncology, https://ascopubs.org/doi/10.1200/JCO-25-00099       Brittany Harvey: Hello and welcome to the ASCO Guidelines podcast, one of ASCO's podcasts delivering timely information to keep you up to date on the latest changes, challenges and advances in oncology. You can find all the shows, including this one at asco.org/podcasts. My name is Brittany Harvey and today I'm interviewing Dr. Ko Un "Clara" Park from Brigham and Women's Hospital, Dana-Farber Cancer Institute, and Dr. Mylin Torres from Glenn Family Breast Center at Winship Cancer Institute of Emory University, co-chairs on “Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer: ASCO Guideline Update.” Thank you for being here today, Dr. Park and Dr. Torres. Dr. Mylin Torres: Thank you, it's a pleasure to be here. Brittany Harvey: And before we discuss this guideline, I'd like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO Conflict of Interest Policy is followed for each guideline. The disclosures of potential conflicts of interest for the guideline panel, including Dr. Torres and Dr. Park, who have joined us here today, are available online with the publication of the guideline in the Journal of Clinical Oncology, which is linked in the show notes. To start us off, Dr. Torres, what is the scope and purpose of this guideline update on the use of sentinel lymph node biopsy in early-stage breast cancer? Dr. Mylin Torres: The update includes recommendations incorporating findings from trials released since our last published guideline in 2017. It includes data from nine randomized trials comparing sentinel lymph node biopsy alone versus sentinel lymph node biopsy with a completion axillary lymph node dissection. And notably, and probably the primary reason for motivating this update, are two trials comparing sentinel lymph node biopsy with no axillary surgery, all of which were published from 2016 to 2024. We believe these latter two trials are practice changing and are important for our community to know about so that it can be implemented and essentially represent a change in treatment paradigms. Brittany Harvey: It's great to hear about these practice changing trials and how that will impact these recommendation updates. So Dr. Park, I'd like to start by reviewing the key recommendations across all of these six overarching clinical questions that the guideline addressed. So first, are there patients where sentinel lymph node biopsy can be omitted? Dr. Ko Un "Clara" Park: Yes. The key change in the current management of early-stage breast cancer is the inclusion of omission of sentinel lymph node biopsy in patients with small, less than 2 cm breast cancer and a negative finding on preoperative axillary ultrasound. The patients who are eligible for omission of sentinel lymph node biopsy according to the SOUND and INSEMA trial are patients with invasive ductal carcinoma that is size smaller than 2 cm, Nottingham grades 1 and 2, hormone receptor-positive, HER2-negative in patients intending to receive adjuvant endocrine therapy, and no suspicious lymph nodes on axillary ultrasound or if they have only one suspicious lymph node, then the biopsy of that lymph node is benign and concordant according to the axillary ultrasound findings. The patients who are eligible for sentinel lymph node biopsy omission according to the SOUND and INSEMA trials were patients who are undergoing lumpectomy followed by whole breast radiation, especially in patients who are younger than 65 years of age. For patients who are 65 years or older, they also qualify for omission of sentinel lymph node biopsy in addition to consideration for radiation therapy omission according to the PRIME II and CALGB 9343 clinical trials. And so in those patients, a more shared decision-making approach with the radiation oncologist is encouraged. Brittany Harvey: Understood. I appreciate you outlining that criteria for when sentinel lymph node biopsy can be omitted and when shared decision making is appropriate as well. So then, Dr. Torres, in those patients where sentinel lymph node biopsy is omitted, how are radiation and systemic treatment decisions impacted? Dr. Mylin Torres: Thank you for that question. I think there will be a lot of consternation brought up as far as sentinel lymph node biopsy and the value it could provide in terms of knowing whether that lymph node is involved or not. But as stated, sentinel lymph node biopsy actually can be safely omitted in patients with low risk disease and therefore the reason we state this is that in both SOUND and INSEMA trial, 85% of patients who had a preoperative axillary ultrasound that did not show any signs of a suspicious lymph node also had no lymph nodes involved at the time of sentinel node biopsy. So 85% of the time the preoperative ultrasound is correct. So given the number of patients where preoperative ultrasound predicts for no sentinel node involvement, we have stated within the guideline that radiation and systemic treatment decisions should not be altered in the select patients with low risk disease where sentinel lymph node biopsy can be omitted. Those are the patients who are postmenopausal and age 50 or older who have negative findings on preoperative ultrasound with grade 1 or 2 disease, small tumors less than or equal to 2 cm, hormone receptor-positive, HER2-negative breast cancer who undergo breast conserving therapy. Now, it's important to note in both the INSEMA and SOUND trials, the vast majority of patients received whole breast radiation. In fact, within the INSEMA trial, partial breast irradiation was not allowed. The SOUND trial did allow partial breast irradiation, but in that study, 80% of patients still received whole breast treatment. Therefore, the preponderance of data does support whole breast irradiation when you go strictly by the way the SOUND and INSEMA trials were conducted. Notably, however, most of the patients in these studies had node-negative disease and had low risk features to their primary tumors and would have been eligible for partial breast irradiation by the ASTRO Guidelines for partial breast treatment. So, given the fact that 85% of patients will have node-negative disease after a preoperative ultrasound, essentially what we're saying is that partial breast irradiation may be offered in these patients where omission of sentinel node biopsy is felt to be safe, which is in these low risk patients. Additionally, regional nodal irradiation is something that is not indicated in the vast majority of patients where omission of sentinel lymph node biopsy is prescribed and recommended, and that is because very few of these patients will actually end up having pathologic N2 disease, which is four or more positive lymph nodes. If you look at the numbers from both the INSEMA and the SOUND trial, the number of patients with pathologic N2 disease who did have their axilla surgically staged, it was less than 1% in both trials. So, in these patients, regional nodal irradiation, there would be no clear indication for that more aggressive and more extensive radiation treatment. The same principles apply to systemic therapy. As the vast majority of these patients are going to have node-negative disease with a low risk primary tumor, we know that postmenopausal women, even if they're found to have one to three positive lymph nodes, a lot of the systemic cytotoxic chemotherapy decisions are driven by genomic assay score which is taken from the primary tumor. And therefore nodal information in patients who have N1 disease may not be gained in patients where omission of sentinel lymph node biopsy is indicated in these low risk patients. 14% of patients have 1 to 3 positive lymph nodes in the SOUND trial and that number is about 15% in the INSEMA trial. Really only the clinically actionable information to be gained is if a patient has four or more lymph nodes or N2 disease in this low risk patient population. So, essentially when that occurs it's less than 1% of the time in these patients with very favorable primary tumors. And therefore we thought it was acceptable to stand by a recommendation of not altering systemic therapy or radiation recommendations based on omission of sentinel nodes because the likelihood of having four more lymph nodes is so low. Dr. Ko Un "Clara" Park: I think one thing to add is the use of CDK4/6 inhibitors to that and when we look at the NATALEE criteria for ribociclib in particular, where node-negative patients were included, the bulk majority of the patients who were actually represented in the NATALEE study were stage III disease. And for stage I disease to upstage into anatomic stage III, that patient would need to have pathologic N2 disease. And as Dr. Torres stated, the rate of having pathologic N2 disease in both SOUND and INSEMA studies were less than 1%. And therefore it would be highly unlikely that these patients would be eligible just based on tumor size and characteristics for ribociclib. So we think that it is still safe to omit sentinel lymph node biopsy and they would not miss out, if you will, on the opportunity for CDK4/6 inhibitors. Brittany Harvey: Absolutely. I appreciate you describing those recommendations and then also the nuances of the evidence that's underpinning those recommendations, I think that's important for listeners. So Dr. Park, the next clinical question addresses patients with clinically node negative early stage breast cancer who have 1 or 2 sentinel lymph node metastases and who will receive breast conserving surgery with whole breast radiation therapy. For these patients, is axillary lymph node dissection needed? Dr. Ko Un "Clara" Park: No. And this is confirmed based on the ACOSOG Z0011 study that demonstrated in patients with 1 to 3 positive sentinel lymph node biopsy when the study compared completion axillary lymph node dissection to no completion axillary lymph node dissection, there was no difference. And actually, the 10-year overall survival as reported out in 2017 and at a median follow up of 9.3 years, the overall survival again for patients treated with sentinel lymph node biopsy alone versus those who were treated with axillary lymph node dissection was no different. It was 86.3% in sentinel lymph node biopsy versus 83.6% and the p-value was non-inferior at 0.02. And so we believe that it is safe for the select patients who are early stage with 1 to 2 positive lymph nodes on sentinel lymph node biopsy, undergoing whole breast radiation therapy to omit completion of axillary lymph node dissection. Brittany Harvey: Great, I appreciate you detailing what's recommended there as well. So then, to continue our discussion of axillary lymph node dissection, Dr. Torres, for patients with nodal metastases who will undergo mastectomy, is axillary lymph node dissection indicated? Dr. Mylin Torres: It's actually not and this is confirmed by two trials, the AMAROS study as well as the SENOMAC trial. And in both studies, they compared a full lymph node dissection versus sentinel lymph node biopsy alone in patients who are found to have 1 to 2 positive lymph nodes and confirmed that there was no difference in axillary recurrence rates, overall survival or disease-free survival. What was shown is that with more aggressive surgery completion axillary lymph node dissection, there were higher rates of morbidity including lymphedema, shoulder pain and paresthesias and arm numbness, decreased functioning of the arm and so there was only downside to doing a full lymph node dissection. Importantly, in both trials, if a full lymph node dissection was not done in the arm that where sentinel lymph node biopsy was done alone, all patients were prescribed post mastectomy radiation and regional nodal treatment and therefore both studies currently support the use of post mastectomy radiation and regional nodal treatment when a full lymph node dissection is not performed in these patients who are found to have N1 disease after a sentinel node biopsy. Brittany Harvey: Thank you. And then Dr. Park, for patients with early-stage breast cancer who do not have nodal metastases, can completion axillary lymph node dissection be omitted? Dr. Ko Un "Clara" Park: Yes, and this is an unchanged recommendation from the earlier ASCO Guidelines from 2017 as well as the 2021 joint guideline with Ontario Health, wherein patients with clinically node-negative early stage breast cancer, the staging of the axilla can be performed through sentinel lymph nodal biopsy and not completion axillary lymph node dissection. Brittany Harvey: Understood. So then, to wrap us up on the clinical questions here, Dr. Park, what is recommended regarding sentinel lymph node biopsy in special circumstances in populations? Dr. Ko Un "Clara" Park: One key highlight of the special populations is the use of sentinel lymph node biopsy for evaluation of the axilla in clinically node negative multicentric tumors. While there are no randomized clinical trials evaluating specifically the role of sentinel lymph nodal biopsy in multicentric tumors, in the guideline, we highlight this as one of the safe options for staging of the axilla and also for pregnant patients, these special circumstances, it is safe to perform sentinel lymph node biopsy in pregnant patients with the use of technetium - blue dye should be avoided in this population. In particular, I want to highlight where sentinel lymph node biopsy should not be used for staging of the axilla and that is in the population with inflammatory breast cancer. There are currently no studies demonstrating that sentinel lymph node biopsy is oncologically safe or accurate in patients with inflammatory breast cancer. And so, unfortunately, in this population, even after neoadjuvant systemic therapy, if they have a great response, the current guideline recommends mastectomy with axillary lymph node dissection. Brittany Harvey: Absolutely. I appreciate your viewing both where sentinel lymph node can be offered in these special circumstances in populations and where it really should not be used. So then, Dr. Torres, you talked at the beginning about how there's been these new practice changing trials that really impacted these recommendations. So in your view, what is the importance of this guideline update and how does it impact both clinicians and patients? Dr. Mylin Torres: Thank you for that question. This update and these trials that inform the update represent a significant shift in the treatment paradigm and standard of care for breast cancer patients with early-stage breast cancer. When you think about it, it seems almost counterintuitive that physicians and patients would not want to know if a lymph node is involved with cancer or not through sentinel lymph node biopsy procedure. But what these studies show is that preoperative axillary ultrasound, 85% of the time when it's negative, will correctly predict whether a sentinel lymph node is involved with cancer or not and will also be negative. So if you have imaging that's negative, your surgery is likely going to be negative. Some people might ask, what's the harm in doing a sentinel lymph node biopsy? It's important to recognize that upwards of 10% of patients, even after sentinel lymph node biopsy will develop lymphedema, chronic arm pain, shoulder immobility and arm immobility. And these can have a profound impact on quality of life. And if there is not a significant benefit to assessing lymph nodes, particularly in someone who has a preoperative axillary ultrasound that's negative, then why put a patient at risk for these morbidities that can impact them lifelong? Ideally, the adoption of omission of sentinel lymph node biopsy will lead to more multidisciplinary discussion and collaboration in the preoperative setting especially with our diagnostic physicians, radiology to assure that these patients are getting an axillary ultrasound and determine how omission of sentinel lymph node biopsy may impact the downstream treatments after surgery, particularly radiation and systemic therapy decisions, and will be adopted in real world patients, and how clinically we can develop a workflow where together we can make the best decisions for our patients in collaboration with them through shared decision making. Brittany Harvey: Absolutely. It's great to have these evidence-based updates for clinicians and patients to review and refer back to. So then finally, Dr. Park, looking to the future, what are the outstanding questions and ongoing trials regarding sentinel lymph node biopsy in early-stage breast cancer? Dr. Ko Un "Clara" Park: I think to toggle on Dr. Torres's comment about shared decision making, the emphasis on that I think will become even more evident in the future as we incorporate different types of de-escalation clinical studies. In particular, because as you saw in the SOUND and INSEMA studies, when we de-escalate one modality of the multimodality therapy, i.e., surgery, the other modalities such as radiation therapy and systemic therapy were “controlled” where we were not de-escalating multiple different modalities. However, as the audience may be familiar with, there are other types of de-escalation studies in particular radiation therapy, partial breast irradiation or omission of radiation therapy, and in those studies, the surgery is now controlled where oftentimes the patients are undergoing surgical axillary staging. And conversely when we're looking at endocrine therapy versus radiation therapy clinical trials, in those studies also the majority of the patients are undergoing surgical axillary staging. And so now as those studies demonstrate the oncologic safety of omission of a particular therapy, we will be in a position of more balancing of the data of trying to select which patients are the safe patients for omission of certain types of modality, and how do we balance whether it's surgery, radiation therapy, systemic therapy, endocrine therapy. And that's where as Dr. Torres stated, the shared decision making will become critically important. I'm a surgeon and so as a surgeon, I get to see the patients oftentimes first, especially when they have early-stage breast cancer. And so I could I guess be “selfish” and just do whatever I think is correct. But whatever the surgeon does, the decision does have consequences in the downstream decision making. And so the field really needs to, as Dr. Torres stated earlier, rethink the workflow of how early-stage breast cancer patients are brought forth and managed as a multidisciplinary team. I also think in future studies the expansion of the data to larger tumors, T3, in particular,reater than 5 cm and also how do we incorporate omission in that population will become more evident as we learn more about the oncologic safety of omitting sentinel lymph node biopsy. Dr. Mylin Torres: In addition, there are other outstanding ongoing clinical trials that are accruing patients right now. They include the BOOG 2013-08 study, SOAPET, NAUTILUS and the VENUS trials, all looking at patients with clinical T1, T2N0 disease and whether omission of sentinel lymph node biopsy is safe with various endpoints including regional recurrence, invasive disease-free survival and distant disease-free survival. I expect in addition to these studies there will be more studies ongoing even looking at the omission of sentinel lymph node biopsy in the post-neoadjuvant chemotherapy setting. And as our imaging improves in the future, there will be more studies improving other imaging modalities, probably in addition to axillary ultrasound in an attempt to accurately characterize whether lymph nodes within axilla contain cancer or not, and in that context whether omission of sentinel lymph node biopsy even in patients with larger tumors post-neoadjuvant chemotherapy may be done safely and could eventually become another shift in our treatment paradigm. Brittany Harvey: Yes. The shared decision making is key as we think about these updates to improve quality of life and we'll await data from these ongoing trials to inform future updates to this guideline. So I want to thank you both so much for your extensive work to update this guideline and thank you for your time today. Dr. Park and Dr. Torres. Dr. Mylin Torres: Thank you. Dr. Ko Un "Clara" Park: Thank you. Brittany Harvey: And thank you to all of our listeners for tuning in to the ASCO Guidelines podcast. To read the full guideline, go to www.asco.org/breast-cancer-guidelines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines app available in the Apple App Store or the Google Play Store. If you have enjoyed what you've heard today, please rate and review the podcast and be sure to subscribe so you never miss an episode.   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  

MotherChip - Overloadr
MotherChip #518 - Um pouco sobre Switch 2, The First Berserker Khazan, R.E.P.O. e mais

MotherChip - Overloadr

Play Episode Listen Later Apr 3, 2025 105:10


O Direct do Nintendo Switch 2 aconteceu, as informações do console foram divulgadas… e não é bem o que a gente esperava. Ao lado do Lucas Eduard, do Nautilus, a gente comenta um pouco do que foi esse Direct e os detalhes compartilhados posteriormente. Além disso, também temos The First Berzerker Khazan, impressões do R36S e mais.Participantes:Lucas EduardHeitor De PaolaAssuntos abordados:03:00 - Um pouco sobre o Switch 253:00 - The First Berzerker Khazan1:04:00 - Impressões R36S1:24:00 - R.E.P.O.1:33:00 - Look OutsideVai comprar jogos na Nuuvem? Use o link de afiliado do Overloadr!Use nosso link de filiado ao fazer compras na Amazon Hosted on Acast. See acast.com/privacy for more information.

The John Batchelor Show
#OzWatch: Nemo's Nautilus as a Tiger Snake attacks Tasmanian fisherman. Jeremy Zakis, New South Wales. #FriendsofHistoryDebatingSociety

The John Batchelor Show

Play Episode Listen Later Feb 16, 2025 8:31


#OzWatch: Nemo's Nautilus as a Tiger Snake attacks Tasmanian fisherman. Jeremy Zakis, New South Wales. #FriendsofHistoryDebatingSociety https://au.news.yahoo.com/aussie-fishermen-scramble-as-determined-tiger-snake-climbs-into-boat-dont-touch-it-000217395.html 1890

Murdaugh Murders Podcast
TSP #82 - JP Miller Tried To Blame Mica's Death On A Cop, New Emails Show + Wayne Miller's Previously Unknown Connection to Mica's Divorce Lawyer

Murdaugh Murders Podcast

Play Episode Listen Later Jan 9, 2025 95:51


Investigative journalists — and proud “podcasters” — Mandy Matney and Liz Farrell reveal the latest in the Mica Francis story, starting with emails from JP Miller and his sidekick Tricia Ross that were sent to police days after Mica's death, urging the police to investigate one of their own in connection to Mica's death.  Yes, seriously. Turns out May 2 was a very bad day for JP Miller. Not only did he have to explain himself to his partners at the Myrtle Beach bar he had a stake in, he seemed to be on a war path as he pointed his finger at Heather Wilson, his alleged former ally at Horry County Police Department. JP — demonstrating once again that he thinks the police work directly for him — wanted the department to investigate Heather for Mica's death because she is the mother of the man Mica was hanging out with on March 11 and the man who JP later called and berated.  Mandy and Liz share the first installment of the texts and emails that came back from reporter Beth Braden's FOIA for communications between JP and the police. Also on the show, how did the waterfront home in Myrtle Beach that Wayne Miller tried to get the courts to force an octogenarian widow who was thought to have dementia to sell end up getting sold to attorney Regina Ward … the attorney who represented Mica in her pending divorce and later Mica's family in their quest to hold JP and his church accountable? We have the scoop — including an interview between Beth and Regina.  Plus, the latest in the Nautilus trial, which had Cory Fleming back up on the stand this week in federal court... and ultimately the jury came back with a verdict in Nautilus' favor, declaring that Cory Fleming owes them $1.25 Million in compensatory damages plus $50.00 in punitive damages.  Stay Tuned, Stay Pesky and Stay in the Sunlight...☀️ Episode Resources Jury decides Cory Fleming is liable for role in Murdaugh insurance scheme, owes $1.25M “Trial begins for Fleming in insurance accusation civil case” - Live5, Jan 6, 2025 “‘In my mind, that was deception': insurance expert testifies in Fleming case” - Live5, Jan 7, 2025 Alex Murdaugh's $14.8 Million Nautilus Judgement - Jan 2, 2025 911 Calls after Mica Francis' Death Timeline Exposing Dirty Southern Money Facebook Page If you are in crisis, please call, text or chat with the Suicide and Crisis Lifeline at 988, or contact the Crisis Text Line by texting TALK to 741741. Premium Members also get access to ad-free listening, searchable case files, written articles with documents, case photos, episode videos and exclusive live experiences with our hosts on lunasharkmedia.com all in one place. CLICK HERE to learn more: https://bit.ly/3BdUtOE. If you are in crisis, please call, text or chat with the Suicide and Crisis Lifeline at 988, or contact the Crisis Text Line by texting TALK to 741741. What We're Buying... Eric Bland's New Book!!! - Mandy's Book in Paperback!! - Marcia Clark's New Book - Amanda Knox's New Book - Tamron Hall's New Book - Erin Lee Carr's Book Peloton - onepeloton.com Find your push. Find your power with Peloton at onepeloton.com. Here's a link to some of our favorite things: https://amzn.to/4cJ0eVn And a special thank you to our other amazing sponsors: Microdose.com, PELOTON, and VUORI. Use promo code "MANDY" for a special offer! *** ALERT: If you ever notice audio errors in the pod, email info@lunasharkmedia.com and we'll send fun merch to the first listener that finds something that needs to be adjusted! This episode was edited thanks to Ashlynn R. near 42:00 *** For current & accurate updates: bsky.app/profile/mandy-matney.com | bsky.app/profile/elizfarrell.com TrueSunlight.com facebook.com/TrueSunlightPodcast/ Instagram.com/TrueSunlightPod Twitter.com/mandymatney Twitter.com/elizfarrell youtube.com/@LunaSharkMedia tiktok.com/@lunasharkmedia Learn more about your ad choices. Visit podcastchoices.com/adchoices