Podcasts about strati

Wer es über Social Media mitbekommen hat, wird gesehen haben, dass Johannes einen neuen Nutrition-Sponsor hat. Tim hat sich deshalb einen steilen Einsteig für Johannes überlegt, um darauf anzusprechen. Des Weiteren möchte Tim wissen, wie Johannes' Taktik für das Trainingslager mit Willy und Strati sein wird. Ein lustiger und cooler Plausch entwickelt sich zwischen den beiden. **Triathlon Coaching** https://personal-triathloncoach.com **Steady:** http://steadyhq.com/aloha-kalle **ALOHA KALLE Strava-Club:** https://www.strava.com/clubs/aloha-kalle **ALOHA KALLE Instagram:** https://www.instagram.com/aloha_kalle/ **Marcus Herbst Instagram** https://www.instagram.com/marcus.herbst/ Conrad Kebelmann Instagram https://www.instagram.com/conrad.kebelmann/ **Website Die Sportmacher GmbH** https://www.diesportmacher.de/

Tento denný podcast, vytváraný s pomocou umelej inteligencie, ponúka unikátny a efektívny spôsob, ako sa dozvedieť o najzaujímavejších udalostiach a článkoch dňa. Umelej inteligencii sa darí analyzovať obrovské množstvo informácií z rôznych zdrojov, aby vybrala tie najrelevantnejšie a najpútavejšie obsahy pre širokú škálu poslucháčov. Každá epizóda je navrhnutá tak, aby poskytla hlboký ponor do vybraných tém, od politiky cez vedecké objavy, až po kultúrne udalosti, a to všetko podané informatívne, prístupne a bez emócií. Podcast je ideálnym spoločníkom pre zaneprázdnených ľudí, ktorí hľadajú pohodlný spôsob, aby zostali informovaní o svetovom dianí bez nutnosti tráviť hodiny čítaním rôznych zdrojov, čím poskytuje efektívny a príjemný spôsob, ako prijímať správy. Návrat do časov minulých: Rusko zavádza na boj s chudobou potravinové lístky https://www.startitup.sk/navrat-do-casov-minulych-rusko-zavadza-na-boj-s-chudobou-potravinove-listky/ Bratislavská MHD cez sviatky. Všetko, čo potrebuješ vedieť https://www.startitup.sk/bratislavska-mhd-cez-sviatky-vsetko-co-potrebujes-vediet/ Finančná správa zaistila doklady v 23 spoločnostiach, ktoré prevádzkovali odberové miesta https://www.startitup.sk/aktualne-financna-sprava-zaistila-doklady-v-23-spolocnostiach-ktore-prevadzkovali-odberove-miesta/ Putin provokatívne vyzýva Západ na súboj: „Vyberte si cieľ, sme pripravení“ https://www.startitup.sk/putin-provokativne-vyzyva-zapad-na-suboj-vyberte-si-ciel-sme-pripraveni/ V Bratislave otvorila nová ikonická kaviareň. Vo Viedni pobláznila davy, u nás ju nájdeš na známej adrese https://www.startitup.sk/v-bratislave-otvorila-nova-ikonicka-kaviaren-vo-viedni-poblaznila-davy-u-nas-ju-najdes-na-znamej-adrese/ Ozbrojený muž v blízkosti Karlovej univerzity takmer na termín výročia streľby? Polícia má jasno https://www.startitup.sk/ozbrojeny-muz-v-blizkosti-karlovej-univerzity-priamo-na-termin-vyrocia-strelby-policia-ma-jasno/ Prokuratúra sa „postavila“ za mimovládky v prípade statusov Šutaja Eštoka. Spochybňuje jeho nevinu https://www.startitup.sk/prokuratura-sa-postavila-za-mimovlaky-v-pripade-statusov-sutaja-estoka-spochybnuje-jeho-nevinu/ Nebezpečné ochorenie vo všetkých okresoch Bratislavského kraja. Hepatitída A sa šíri, varuje RÚVZ https://www.startitup.sk/nebezpecne-ochorenie-vo-vsetkych-okresoch-bratislavskeho-kraja-hepatitida-a-sa-siri-varuje-ruvz/ „Pellegrini je nechcená a drahá nevesta.“ Biznis Dráčika rastie napriek kontroverznému blogu https://www.startitup.sk/pellegrini-je-nechcena-a-draha-nevesta-biznis-dracika-rastie-napriek-kontroverznemu-blogu/ Ukrajincov drtia Rusi a Kórejci v Kurskej oblasti, priznáva major. Stratiť už mali polovicu územia https://www.startitup.sk/ukrajincov-drtia-rusi-a-korejci-v-kurskej-oblasti-priznava-major-stratit-uz-mali-polovicu-uzemia/

Tento denný podcast, vytváraný s pomocou umelej inteligencie, ponúka unikátny a efektívny spôsob, ako sa dozvedieť o najzaujímavejších udalostiach a článkoch dňa. Umelej inteligencii sa darí analyzovať obrovské množstvo informácií z rôznych zdrojov, aby vybrala tie najrelevantnejšie a najpútavejšie obsahy pre širokú škálu poslucháčov. Každá epizóda je navrhnutá tak, aby poskytla hlboký ponor do vybraných tém, od politiky cez vedecké objavy, až po kultúrne udalosti, a to všetko podané informatívne, prístupne a bez emócií. Podcast je ideálnym spoločníkom pre zaneprázdnených ľudí, ktorí hľadajú pohodlný spôsob, aby zostali informovaní o svetovom dianí bez nutnosti tráviť hodiny čítaním rôznych zdrojov, čím poskytuje efektívny a príjemný spôsob, ako prijímať správy.  0.34 - Návrat do časov minulých: Rusko zavádza na boj s chudobou potravinové lístky https://www.startitup.sk/navrat-do-casov-minulych-rusko-zavadza-na-boj-s-chudobou-potravinove-listky/ 1:33 - Bratislavská MHD cez sviatky. Všetko, čo potrebuješ vedieť https://www.startitup.sk/bratislavska-mhd-cez-sviatky-vsetko-co-potrebujes-vediet/ 2:31 - Finančná správa zaistila doklady v 23 spoločnostiach, ktoré prevádzkovali odberové miesta https://www.startitup.sk/aktualne-financna-sprava-zaistila-doklady-v-23-spolocnostiach-ktore-prevadzkovali-odberove-miesta/ 3:12 - Putin provokatívne vyzýva Západ na súboj: „Vyberte si cieľ, sme pripravení“ https://www.startitup.sk/putin-provokativne-vyzyva-zapad-na-suboj-vyberte-si-ciel-sme-pripraveni/ 3:40 - V Bratislave otvorila nová ikonická kaviareň. Vo Viedni pobláznila davy, u nás ju nájdeš na známej adrese https://www.startitup.sk/v-bratislave-otvorila-nova-ikonicka-kaviaren-vo-viedni-poblaznila-davy-u-nas-ju-najdes-na-znamej-adrese/ 4:22 - Ozbrojený muž v blízkosti Karlovej univerzity takmer na termín výročia streľby? Polícia má jasno https://www.startitup.sk/ozbrojeny-muz-v-blizkosti-karlovej-univerzity-priamo-na-termin-vyrocia-strelby-policia-ma-jasno/ 5:00 - Prokuratúra sa „postavila“ za mimovládky v prípade statusov Šutaja Eštoka. Spochybňuje jeho nevinu https://www.startitup.sk/prokuratura-sa-postavila-za-mimovlaky-v-pripade-statusov-sutaja-estoka-spochybnuje-jeho-nevinu/ 5:31 - Nebezpečné ochorenie vo všetkých okresoch Bratislavského kraja. Hepatitída A sa šíri, varuje RÚVZ https://www.startitup.sk/nebezpecne-ochorenie-vo-vsetkych-okresoch-bratislavskeho-kraja-hepatitida-a-sa-siri-varuje-ruvz/ 5:59 - „Pellegrini je nechcená a drahá nevesta.“ Biznis Dráčika rastie napriek kontroverznému blogu https://www.startitup.sk/pellegrini-je-nechcena-a-draha-nevesta-biznis-dracika-rastie-napriek-kontroverznemu-blogu/ 6.38 - Ukrajincov drtia Rusi a Kórejci v Kurskej oblasti, priznáva major. Stratiť už mali polovicu územia https://www.startitup.sk/ukrajincov-drtia-rusi-a-korejci-v-kurskej-oblasti-priznava-major-stratit-uz-mali-polovicu-uzemia/

Risorse Gratuite: CORSO GRATIS REVIT- BIM: https: //bit.ly/34OJRVS  CORSO GRATIS AUTOCAD: https://bit.ly/3fNrgjk   CORSO GRATIS RENDERING: https: //bit.ly/3uOt4Nd  ACCATASTA QUIZ - SCOPRI CHE ACCATASTATORE SEI: https://bit.ly/3IxzOHb  BIM QUIZ - SCOPRI CHE BIM SEI: https://bit.ly/3q12O3E   PILLOLE DI CANTIERE: https://bit.ly/3vQc4da  PILLOLE DI COMPUTO METRICO: https://bit.ly/3srh7ja  PILLOLE DI DOCFA: https://bit.ly/3KzfpCc  PILLOLE DI PRATICHE EDILIZIE: http://bit.ly/3zdcQSt Le 8 REGOLE D'ORO PER FARE UN BUON RENDER: https://bit.ly/3zUgrnk  PRENOTA UNA CONSULENZA TELEFONICA GRATUITA:  https://bit.ly/3vQuEQ4 ========================================================== Per seguire ADARA Architettura: YOUTUBE: Iscriviti e attiva la campanella https://bit.ly/36AMlav WEBSITE: https://bit.ly/2X4BbrG BLOG: https://bit.ly/36w3GS1 PAGINA FB: https://bit.ly/2ywKQ0q GRUPPO SEGRETO FB "Progettazione Competitiva": https://bit.ly/2X6rn0h ========================================================== Podcast: SPOTIFY: https://spoti.fi/2LYKdzM OVERCAST: https://bit.ly/3d6FFU1 APPLE PODCAST: https://apple.co/3d365pG GOOGLE PODCAST: https://bit.ly/2LWqBwq ANCHOR: https://bit.ly/2Adi7OB ========================================================== #AdaraArchitetturaCentroAutodesk #Università 

Tento denný podcast, vytváraný s pomocou umelej inteligencie, ponúka unikátny a efektívny spôsob, ako sa dozvedieť o najzaujímavejších udalostiach a článkoch dňa. Umelej inteligencii sa darí analyzovať obrovské množstvo informácií z rôznych zdrojov, aby vybrala tie najrelevantnejšie a najpútavejšie obsahy pre širokú škálu poslucháčov. Každá epizóda je navrhnutá tak, aby poskytla hlboký ponor do vybraných tém, od politiky cez vedecké objavy, až po kultúrne udalosti, a to všetko podané informatívne, prístupne a bez emócií. Podcast je ideálnym spoločníkom pre zaneprázdnených ľudí, ktorí hľadajú pohodlný spôsob, aby zostali informovaní o svetovom dianí bez nutnosti tráviť hodiny čítaním rôznych zdrojov, čím poskytuje efektívny a príjemný spôsob, ako prijímať správy. Opravovňa ukrajinskej vojenskej techniky na Slovensku končí. Nemci centrum presúvajú domov https://www.startitup.sk/opravovna-ukrajinskej-vojenskej-techniky-na-slovensku-konci-nemci-centrum-presuvaju-domov/ Prelomová technológia: Nové AI kamery odhaľujú vodičov pod vplyvom zakázaných látok https://www.startitup.sk/prelomova-technologia-nove-ai-kamery-odhaluju-vodicov-pod-vplyvom-zakazanych-latok/ Šimkovičová odtajnila dátum, kedy zaznie nová hymna: „Som zvedavá na reakcie, ale zatiaľ boli len a len pozitívne“ https://www.startitup.sk/simkovicova-odtajnila-datum-kedy-zaznie-nova-hymna-som-zvedava-na-reakcie-ale-zatial-boli-len-a-len-pozitivne/ Európa vyzýva Muska do súboja: Naratív, že Starlink vyhral a všetci ostatní sú mŕtvi, nie je pravda https://www.startitup.sk/europa-vyzyva-muska-do-suboja-narativ-ze-starlink-vyhral-a-vsetci-ostatni-su-mrtvi-nie-je-pravda/ Slovensko a Rusko zostávajú nepriateľmi: Moskva ohlásila, že sa to napriek snahe Ficovej vlády nezmení https://www.startitup.sk/slovensko-a-rusko-zostavaju-nepriatelmi-moskva-ohlasila-ze-sa-to-napriek-snahe-ficovej-vlady-nezmeni/ Ak ho máš doma, určite ho nepoužívaj. Hygienici varujú pred nebezpečným „vianočným“ výrobkom https://www.startitup.sk/ak-ho-mas-doma-urcite-ho-nepouzivaj-hygienici-varuju-pred-nebezpecnym-vianocnym-vyrobkom/ Vláda schválila slovenskú vesmírnu stratégiu: Vidí v nej sľubnú oblasť na posilnenie ekonomického rastu https://www.startitup.sk/vlada-schvalila-slovensku-vesmirnu-strategiu-vidi-v-nej-slubnu-oblast-na-posilnenie-ekonomickeho-rastu/ Harabin sa musí ospravedlniť: Dlhoročný súdny proces s Esetom rozhodol v prospech spoločnosti https://www.startitup.sk/harabin-sa-musi-ospravedlnit-dlhorocny-sudny-proces-s-esetom-rozhodol-v-prospech-spolocnosti/ Revolučné zistenie: Po prijatí transplantovaného orgánu môžeš po darcovi zdediť aj spomienky, chute či fóbie https://www.startitup.sk/revolucne-zistenie-po-prijati-transplantovaneho-organu-mozes-po-darcovi-zdedit-aj-spomienky-chute-ci-fobie/ Ukrajincov drtia Rusi a Kórejci v Kurskej oblasti, priznáva major. Stratiť už mali polovicu územia Ukrajina do NATO nevstúpi, Rusko si ponechá obsadené územia, vyhlásil Fico pred summitom EÚ https://www.startitup.sk/ukrajina-do-nato-nevstupi-rusko-si-ponecha-obsadene-uzemia-vyhlasil-fico-pred-summitom-eu/ Lidl priblížil, ako sa znižovanie DPH prejaví na cenách potravín na Slovensku od januára 2025 https://www.startitup.sk/lidl-priblizil-ako-sa-znizovanie-dph-prejavi-na-cenach-potravin-na-slovensku-od-januara-2025/ Na Vianoce predáš viac než kedykoľvek predtým. Odborníci radia, ako na čo najvyššie tržby https://www.startitup.sk/na-vianoce-predas-viac-nez-kedykolvek-predtym-odbornici-radia-ako-na-co-najvyssie-trzby/

Ci addentriamo nelle stanze del ruling di Duskmourn insieme al buon Jacopo.... dopo questo episodio non vi perderete più, garantitoLINK per il canale Telegram: https://t.me/+dXU4Ko4N2CszODRkTrovi il video dell'episodio qui: https://www.youtube.com/channel/UCMkQqseTypha6-n8Lsba6KwLINK per il canale Telegram: https://t.me/+dXU4Ko4N2CszODRkIn Risposta Scombo è sponsorizzato da Fantasia store, il paradiso di tutti noi nerd! Sul loro store troverete tutto ciò che un giocatore di Magic può desiderare!

 „A tak nikto z vás nemôže mi byť učeníkom, ak sa nezriekne všetkého, čo má.“ (L 14:33) Keď Ježiš povedal: „Kto z vás neopustí všetko, čo má, nemôže byť mojím učeníkom,“ myslel tým, že kresťania musia zložiť sľub chudoby a rozdať všetok majetok? Nie. Ježiš chcel povedať, že sa musíme vzdať nároku na svoj majetok. […] Greg Laurie

Il buon Jack Lawyers torna per parlarci delle meccaniche di Bloomburrow e per rispondere alle vostre domande!! LINK per il canale Telegram: https://t.me/+dXU4Ko4N2CszODRkTrovi il video dell'episodio qui: https://www.youtube.com/channel/UCMkQqseTypha6-n8Lsba6KwIn Risposta Scombo è sponsorizzato da Fantasia store, il paradiso di tutti noi nerd! Sul loro store troverete tutto ciò che un giocatore di Magic può desiderare!

Roberto, celebre per la sua ricerca continua di tendenze nel mondo della bakery, presenta il suo ultimo capolavoro: il Triplo Burger a tre strati. Questo nuovo prodotto si distingue per la sua capacità unica di offrire un'esperienza gastronomica veloce ma ricca di qualità, grazie al suo innovativo design a tre strati. Ideato per chi cerca un'alternativa unica e originale ai burger tradizionali, il Triplo Burger di Roberto è semplice da preparare e perfetto per un pasto rapido e soddisfacente.

Dopo QUATTRO anni torna il buon Jacopo Strati con questo episodio dedicato al ruling di Modern Horizons 3 e alle vostre domande!Trovi il video dell'episodio qui: https://www.youtube.com/channel/UCMkQqseTypha6-n8Lsba6KwIn Risposta Scombo è sponsorizzato da Fantasia store, il paradiso di tutti noi nerd! Sul loro store troverete tutto ciò che un giocatore di Magic può desiderare!

Welcome, to episode #88 of The Exploring Antinatalism Podcast! A podcast, showcasing the wide range of perspectives & ideas throughout Antinatalism as it exists today, through interviews with Antinatalist & non-Antinatalist thinkers & creators of all kinds - now running 5 years strong! I'm your host, Amanda Sukenick, and today, I'm speaking with fellow moderator of r/Antinatalism, core member of Antinatalism New Zealand, author of the forthcoming paper Introducing Anatalism, – Vito T. Strati! https://www.antinatalism.org.nz/homehttps://www.facebook.com/groups/293701685915977https://twitter.com/AntinatalismNZCONTEST!: Make a response of some kind to the book, and enter it to win a free copy signed by both authors! Submit your entry by June 15th either by leaving a comment letting me know about, or email me at exploringantinatalism@gmail.com! 3 winners will be selected! Winners will be announced on during the July 1st episode of The Exploring Antinatalism Podcast! Visit the Towarzystwo Naukowe im. Stanisława Andreskiego merch shop! HERE!: https://tnsa.myspreadshop.pl/Buy Antinatalism, Extinction, and the End of Procreative Self-Corruption HERE!: https://www.cambridge.org/us/universitypress/subjects/psychology/developmental-psychology/antinatalism-extinction-and-end-procreative-self-corruption?format=PBAlso on Amazon!: https://www.amazon.com/Antinatalism-Extinction-Procreative-Self-Corruption-Neuroethics/dp/1009455303/ref=tmm_pap_swatch_0?_encoding=UTF8&qid=&sr= Read it for free HERE!: https://www.cambridge.org/core/elements/antinatalism-extinction-and-the-end-of-procreative-selfcorruption/A88E18CA50EF6D919CE459C007447DB4#elements DOI: https://doi.org/10.1017/9781009455299 Watch our video on the book: HERE!: https://www.youtube.com/watch?v=zyqgQfcMeyY

Una puntata diversa, la 30esima della quinta stagione, dove abbiamo avuto come ospite @pabo991e @vitucciovisceglia ideatori di @stratimusiccontest (per quale siamo partner artistici) il contest musicale che si terrà durante la 21esima edizione della Festa della Cipolla Rossa organizzata dalla @prolocoacquaviva. Questa è finalmente un'occasione per fare rete, per parlare di musica e di valorizzazione dei talenti artistici del nostro territorio. Da sempre We Believe in Music è stata punto di riferimento per gli artisti emergenti pugliesi, dove oltre 100 artisti, band e deejay hanno varcato la nostra casa per far conoscere al pubblico la loro musica, le loro emozioni, le persone che sono dietro il magico mondo chiamato musica. Strati Music Contest non può che definirsi altro che un Trait d'union con We Believe in Music: è un contest musicale rivolto ad artisti e musicisti che vanno dai 15 anni in su, in formazioni singole o strutturati con band, senza limiti di genere musicale. Il tema leader del contest è quello della valorizzazione dei talenti artistici e musicali, esattamente quello che ogni sabato da 5 anni a questa parte facciamo con le nostre interviste nel nostro radio show condotto da @chiccovoice , @skattone e la regia di @angel_white89I Premi verranno assegnati in seguito alle valutazioni di una giuria che si occuperà dell'assegnazione di 4 PREMI in totale. Verranno premiati i primi tre concorrenti in base alla valutazione INSINDACABILE della giuria prefissata.Oltre ai migliori 3 partecipanti, verrà assegnato un premio al miglior testo: il vincitore potrà essere uno fra i 15 partecipanti al contest, e in coerenza con il tema leader della manifestazione, avrà un peso importante ai fini della valutazione, la sua attinenza con temi di territorialità e folclore.I premi in palio saranno dunque assegnati in occasione della premiazione che avrà luogo ad Acquaviva delle Fonti il giorno 20 luglio 2024 , in seguito all'esibizione dei tre artisti finalisti. Sei un'artista, fai parte di una band e vuoi partecipare al nostro programma?Vuoi farti conoscere, far ascoltare la tua musica e condividere quella che ami?We Believe in Music, è il contenitore che fa per te! Nessuna intervista preimpostata, nessuna domanda concordata, ma una semplice chiacchierata tra amici che amano la musica!Contattaci in direct sui nostri social, siamo pronti a darti voce!

Ďalší týždeň prešiel ako voda a tak sme tu s novým NBA Podcastom. Tentokrát sme sa v trojici pozreli na kontrakty pre Allena, či Holiday a výnimočnú sezónu Paola Banchera. Nechýbala predikcia playin zápasov, kde sme sa snažili zachovať objektivitu a v druhej časti podcastu sme odpovedali na otázku, ktorí hráči majú najviač čo stratiť v tohtoročnom playoff. Prediskutovali sme potenciálne preroblí v Milwaukee, Irvingovú vizitku za posledných 8 rokov, dvojicu pivotov z Clevelandu, ale takisto aj mladých rozohrávačov v Orlande. Nechýbali evergreeny ako Gobert, Harden, CP3, či Jaylen Brown. Užívajte!  00:00 Intro 03:06 Holiday, Allen, Banchero… 23:21 Koniec základnej časti 33:33 Sixers vs Heat 39:37 Bulls vs Hawks 41:50 Pels vs Lakers 49:30 Kings vs Warriors 54:14 Damian Lillard 01:00:46 Outro --- Send in a voice message: https://podcasters.spotify.com/pod/show/druhalajna/message

Je zvláštne, keď píše apoštol Pavol o Izraelcoch, ktorých vyviedol Pán Boh z Egyptského otroctva skrze mnohé znamenia a zázraky, že stratili Božie zaľúbenie. Vyzerá to, ako by bol Pán Boh náladový. Jeden deň ich zachraňuje a potom ich nechá zomrieť na púšti, pretože vo väčšine z nich nemal zaľúbenie. Ak však vylúčime to, že Pán Boh nie je náladový, tak ako k tomu mohlo dôjsť? Ako to, že prestali byť Bohu milí? A na koniec ešte dôležitá otázka, môže sa to stať aj nám?

Routesetting as a shorter setter doesn't come with a shortage of challenges and frustrations. But that's far from the full story for Abby Tran, Assistant Headsetter at The Circuit Bouldering Gyms in Portland, Oregon. On this episode of the Impact Driver podcast, unabashedly short setters Abby and Holly Chen discuss some of the benefits that shorter people bring to the setting world; the importance of empathy, trust and respect on setting teams; training for setting as a shorter setter and a setter in general; enjoying both aesthetic climbs and a “wrestle” on the wall; avoiding “featherbagging” as well as sandbagging; and at one point, Abby's cat sneaks onto the show. Our host is Holly Yu Tung Chen with music by Devin Dabney, and sponsors Essential and Strati.

"Tak ako druhá dzurindova vláda stratila väčšinu, tak postupne môže salámovou metódou - a pod tlakom verejnosti, stratiť parlamentú väčšinu aj tento Ficizmus, hovorí o občianskych protestoch expremiérka Iveta Radičová.Vláda má za sebou prvých sto dní vo funkcii, okrem snahy razantne zmeniť trestnú politiku a vymazať Špeciálnu prokuratúru z mapy slovenskej reality, však za novou vládou veľa reálnych výsledkov vidieť nie je. Sľuby z kampane o boji s infláciou či lacnejších potravinách sa na realitu zatiaľ nepremenili. Naopak, vládna moc sa rozhodna rýchlo personálne vyčistiť prakticky všetko, na čo má aspoň nejaký dosah a obsadiť tieto miesta sebe lojálnymi ľuďmi. Razancia novej moci tak postavila na nohy verejnosť a námestia sa plnia čoraz väčšími davmi rozhorčenej verejnosti. Priekopy medzi koalíciou a opozíciou sa roztvárajú čoraz viac a tak sa sľuby z kampane o konci doby svárov a ére pokoja nenaplnili."Nepomôže iné, iba keď každý jeden z nás si uvedomí, či naozaj chceme vyháňať mladých ľudí z tejto krajiny preto, lebo tlieskame nekrôchaným a vulgárnym politikom, ktorí sa na nás ešte aj zabávajú. No a potom nám "veľkoryso" hádžu nejakú almužnu, aby nám zalepili oči a bez toho, aby priznali, že nevedia postaviť seriózny štátny rozpočet, zadlžujú nás na ďalšie generácie a bez toho aby priznali, že zlyhávajú v reformách školstva či zdravotníctva. Naozaj im to budeme dlhodobo tolerovať?" pýta sa v dnešnom podcaste bývalá premiérka Iveta Radičová. Kam sa uberá slovenská spoločnosť za vlády Fica IV. a nevracia sa nová vládna moc k praktikám normalizácie? Aký je zmysel občianskych protestov, keď prieskumy preferencií politických strán ukazujú rastúcu podporu ficovho SMERu? Dokáže nová vláda naplniť svoje veľkorysé a rozšafné predvolebné sľuby tvárou v tvár rozvráteným verejným financiám? Prečo z tejto krajiny uteká čoraz viac našich detí a prečo odmieta žiť v tejto našej slovenskej reality show? No a napokon, prečo je opakované víťazstvo SMERu priamym dôsledkom zlyhania slovenskej politickej pravice?Témy a otázky pre profesorku sociológie a expremiérku Ivetu Radičovú. Počúvate ráno Nahlas, pekný deň a pokoj v duši praje Braňo Dobšinský.

"Tak ako druhá dzurindova vláda stratila väčšinu, tak postupne môže salámovou metódou - a pod tlakom verejnosti, stratiť parlamentú väčšinu aj tento Ficizmus, hovorí o občianskych protestoch expremiérka Iveta Radičová.Vláda má za sebou prvých sto dní vo funkcii, okrem snahy razantne zmeniť trestnú politiku a vymazať Špeciálnu prokuratúru z mapy slovenskej reality, však za novou vládou veľa reálnych výsledkov vidieť nie je. Sľuby z kampane o boji s infláciou či lacnejších potravinách sa na realitu zatiaľ nepremenili. Naopak, vládna moc sa rozhodna rýchlo personálne vyčistiť prakticky všetko, na čo má aspoň nejaký dosah a obsadiť tieto miesta sebe lojálnymi ľuďmi. Razancia novej moci tak postavila na nohy verejnosť a námestia sa plnia čoraz väčšími davmi rozhorčenej verejnosti. Priekopy medzi koalíciou a opozíciou sa roztvárajú čoraz viac a tak sa sľuby z kampane o konci doby svárov a ére pokoja nenaplnili."Nepomôže iné, iba keď každý jeden z nás si uvedomí, či naozaj chceme vyháňať mladých ľudí z tejto krajiny preto, lebo tlieskame nekrôchaným a vulgárnym politikom, ktorí sa na nás ešte aj zabávajú. No a potom nám "veľkoryso" hádžu nejakú almužnu, aby nám zalepili oči a bez toho, aby priznali, že nevedia postaviť seriózny štátny rozpočet, zadlžujú nás na ďalšie generácie a bez toho aby priznali, že zlyhávajú v reformách školstva či zdravotníctva. Naozaj im to budeme dlhodobo tolerovať?" pýta sa v dnešnom podcaste bývalá premiérka Iveta Radičová. Kam sa uberá slovenská spoločnosť za vlády Fica IV. a nevracia sa nová vládna moc k praktikám normalizácie? Aký je zmysel občianskych protestov, keď prieskumy preferencií politických strán ukazujú rastúcu podporu ficovho SMERu? Dokáže nová vláda naplniť svoje veľkorysé a rozšafné predvolebné sľuby tvárou v tvár rozvráteným verejným financiám? Prečo z tejto krajiny uteká čoraz viac našich detí a prečo odmieta žiť v tejto našej slovenskej reality show? No a napokon, prečo je opakované víťazstvo SMERu priamym dôsledkom zlyhania slovenskej politickej pravice?

Majo dal do vianočnej dedinky ovečku z kinderka a aj keď je február, vianočná dedinka stále svieti. Adriana má ešte 4 vanilkové rožky z Vianoc, hoci dokopy ich bolo napečených iba 9. Matky sú veľmi obetavé – keď dieťa hodí figúrku z kinderka do koša v kaderníctve, pre matku to znamená prehrabávať sa cudzími vlasmi. Stratiť obľúbenú hračku je katastrofa! Adrianin syn tak nechal batoh s najobľúbenejšími hračkami na letisku v Bangkoku, Mišin syn zabudol mojkáčika na spanie v Prahe. Iba jeden z týchto príbehov mal happy end. Keď bola Adriana malá, hrávala sa s Martinkom. Ten sa chcel hrať v jej izbe aj vtedy, keď nebola doma. Zo zákulisia rádia: Zohnať Adyho Hajdu na telefón bola náročnejšia úloha, ako si Majo, Miša a Adriana mysleli. Ak máte zlé číslo, tak nielenže sa nespojíte s hercom, ale ani sa neobjednáte na sono prsníkov. Slovenské dabingy, ktoré sa naozaj podarili: Frasier, Priatelia, či Dempsey a Makepeacová.

Ah i Dursley, ah i Weasley... Ah gli ospiti di Ripotter! SUPPORTA RIPOTTER SU PATREON: http://patreon.com/RIPOTTER SEGUICI SU INSTAGRAM: https://www.instagram.com/ripotterpodcast/

Ukrajina si v sobotu pripomenie 90. výročie národnej tragédie, ktorá stála životy miliónov Ukrajincov. Stalinova politika zameraná na potlačenie ukrajinského odporu a zlomenie ukrajinského vidieka, ktorí sa bránil kolektivizácii, vyústila do hladovania, ktoré v Ukrajine volajú Holodomorom.V priebehu niekoľkých mesiacov na prelome rokov 1932 a 1933 zomreli vyše štyri milióny ľudí, no obetí mohlo byť viac. Mnohé ukrajinské dediny v centrálnej časti Ukrajiny, na východe i juhu totiž hladomor zdecimoval spôsobom, že sa už nenašiel nikto živý, kto by obete nahlásil úradom. Sovieti ľuďom vzali všetko, čo by ich mohlo zasýtiť: nebrali im len obilie, osivo či vypestovanú zeleniny a ovocie. Boľševici rodinám konfiškovali aj domáce zvieratá a odevy. Milióny ľudí boli odkázaní na to, čo našli v prírode v okolí dediny - mali zakázané cestovať za jej hranice. Pamätníci opisovali, ako jedli žihľavu, buriny, chytali ježkov, vtáky a žaby. „Moska odjakživa vnímala Ukrajinu ako niečo, čo nechce pustiť z rúk. Stalin nechal Ukrajincom skonfiškovať jedlo preto, aby ich pokoril," približuje v podcaste reportérka Stanislava Harkotová, ktorá pôsobí na Ukrajine. Podľa nej je téma Holodomoru pre Ukrajincov dodnes veľmi citlivo vnímaná. „V lete, keď Rusi bránili Ukrajine v exporte obilia do iných krajín, tak Ukrajinci hovorili práve o tom, že to snáď nie je možné, že sa po týchto rokoch opäť pália obilie a opäť sa snažia vytvoriť situáciu, ktorá môže niekde ohrozovať potravinovú bezpečnosť," približuje Harkotová.V podcaste tiež budete počuť, čo presne sa stalo pred 90 rokmi a ako si tieto udalosti Ukrajina pripomína dnes.Rozhovor nahrala Denisa Hopková.

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Retail plays a key role in most gyms' day-to-day operations, while also being a visual component of the facility, so today's conversation is all about gym retail: what sales strategies work well, what doesn't work so well; what sells, what doesn't sell. We speak with Brad Werntz, President of the two Boulders climbing gyms in Madison, Wisconsin, both of which have retail components. As a longtime gym operator and former sales representative for various climbing brands, Werntz has seen the business value of a well-managed retail area, as well as some potential pitfalls to avoid. Our host is John Burgman with music by Devin Dabney, and sponsors Strati and Essential.

Wade Desai is the Director of Climbing at ASCEND in the Pittsburgh area. As you'll hear, he certainly loves climbing, but he's also passionate about slacklining and accomplished at it too. Since starting at ASCEND in 2017, he's seen slacklining take off as a programming offering and has been helping lead the charge. Could more climbing gyms offer slacklining? And if so, what are some of the steps that a gym should take to get a slacklining program started? Those questions guide today's conversation, and we'll also hear more about Desai's fascinating transition from a doctor in the medical field to a director in the climbing gym industry. Our host is John Burgman with music by Devin Dabney, and sponsors Strati and EP Climbing.

Today's episode features a conversation with attorney Jason Pill. Jason is a longtime climber, and he currently works with the Phelps Dunbar law firm in Tampa, Florida. His main areas of focus tend to be labor and employment law, but he's written articles for CBJ on a wide range of legal topics, including an entire Ask a Lawyer series. In this episode, Jason shares some insights about waivers and how protective they really are against lawsuits, some landmark cases and rulings that gym owners should know about, and legal challenges that gym owners might be facing in the years to come. Our host is John Burgman with music by Devin Dabney, and sponsors Kilter and Strati.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.05.05.539557v1?rss=1 Authors: Christofidou, E., Tomazou, M., Voutouri, C., Michael, C., Stylianopoulos, T., Spyrou, G. M., Strati, K. Abstract: Oct4 is a pioneer transcription factor regulating pluripotency. However, it is poorly known whether Oct4 has an impact on somatic cells. We generated OCT4 knockout clonal cell lines using immortalized human skin keratinocytes to identify a functional role for the protein. Here we report that Oct4-deficient cells transitioned into a mesenchymal-like phenotype with enlarged size and shape, exhibited accelerated migratory behavior, decreased adhesion and appeared arrested at G2/M cell cycle checkpoint. Oct4 absence had a profound impact on cortical actin organization, with loss of microfilaments from cell periphery, increased puncta deposition in the cytoplasm and stress fiber formation. E-cadherin, beta-catenin and ZO1 were almost absent from cell-cell contacts while fibronectin deposition was markedly increased in ECM. Mapping of the transcriptional and chromatin profiles of Oct4-deficient cells revealed that Oct4 controls the levels of cytoskeletal, ECM and differentiation related genes, whereas epithelial identity is preserved through transcriptional and non-transcriptional mechanisms. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

No episódio de hoje, Luís Montanari bate um papo com André Bernardo, Sócio Diretor da Strati, abrindo os detalhes de toda a sua jornada como um MSP. Visite o site da ADDEE >> https://addee.com.br Entre em contato com a ADDEE >> contato@addee.com.br Siga a ADDEE >> @addee Instagram >> instagram.com/mspcast/ YouTube >> youtube.com/@cortesmspcast Para mais episódios >> mspcast.com.br Episódio sobre Onboarding >> https://open.spotify.com/episode/0FDr2UPGoM0N7zTiwADwIV #MSPCast #SouMSP #ADDEE #MSP #SouMSP #ServiçosGerenciados

In this episode we sit down with routesetter and wildlife biologist Sierra McMurry. They experience obstacles every routesetter experiences, such as navigating fair pay and equitable workloads, but they also navigate obstacles that others might not, like how they take up space as a queer setter and communicate about sensitive topics with colleagues. We discussed the sustainability of routesetting careers, what the industry is doing right, as well as where we might go in the future. We also talked about how notable mentors can teach us lessons that we carry with us as the industry evolves. That idea begs the question: What wisdom will you hold onto and keep applying to your setting leadership style as times change, and what will you let go of to make way for something new? Our host is Holly Yu Tung Chen with sound editing by Devin Daney, and sponsors Essential Climbing and Strati.

Nesse episódio do MSP Cast, Luís Montanari convida Danyele Palmieri (Head de Marketing da Strati) para falar sobre Marketing para MSPs, as melhores estratégias e as maiores dificuldades dessa área. Confira tudo nesse episódio! Conheça o Localize MSP: https://localizemsp.com.br Visite o site da ADDEE: https://addee.com.br Entre em contato com a ADDEE: contato@addee.com.br Siga a ADDEE nas redes: @addee Siga o MSP Cast no Instagram: instagram.com/mspcast/ Inscreva-se no canal do MSP Cast no YouTube: youtube.com/@cortesmspcast Para mais episódios: https://mspcast.com.br #MSPCast #SouMSP #ADDEE #RedesSociais #Marketing #RedesSociais #MarketingDeConteúdo #Conteúdo

No episódio de hoje, Luís Montanari conversa com Denny Roger (Head de SOC da Strati) para falar sobre cibersegurança, as maiores tendências desse mercado, as maiores ameaças atualmente e como o MSP pode estar sempre atualizado para qualquer imprevisto. Visite o site da ADDEE: https://addee.com.br Entre em contato com a ADDEE: contato@addee.com.br Siga a ADDEE nas redes: @addee Siga o MSP Cast no Instagram: instagram.com/mspcast/ Inscreva-se no canal do MSP Cast no YouTube: youtube.com/@cortesmspcast Para mais episódios: mspcast.com.br Saiba mais sobre o Roadshow: https://materiais.addee.com.br/roadshow-addee-sul-2023 #MSPCast #SouMSP #ADDEE #MSP #SouMSP #ServiçosGerenciados

Mike Strati, CLF (Chartered Leadership Fellow) – Culture Index Executive Advisor, Owner MJS Stratigic Consulting. Mike's passion & mission has been “helping people reach their full potential, beyond their expectations”.  Leadership is engrained in his soul, whether playing with the US Men's Olympic Soccer program, Coaching State and National Champions, breaking barriers in 150 year old company, sitting on boards – his insatiable appetite to engage & challenge high-impact leaders is unrelenting. He finds TIME & MONEY https://www.cultureindex.com The Mesa Chamber of Commerce Inside Business Podcast is a production of the Mesa Chamber of Commerce. Each episode is recorded in the University of Phoenix Podcast Studio. Inquiries regarding the MCIBP can be made via email to info@mesachamber.org.  The Podcast interviews members and individuals/organizations on topics of interest to mesa Chamber members. Learn more at http://mesachamber.org  ©2023 Mesa Chamber of Commerce

Le lunghe giornate sugli sci a volte sono davvero un'impresa. Oggi vi diamo qualche consiglio su cosa indossare per garantirvi il massimo comfort anche durante le giornate più fredde! ❄️Ospite il nostro Product Manager Winter Piero Berbenni.

Ispirato al lavoro "Strati", di Zerocalcare, questo podcast realizzato dai ragazzi e dalle ragazze della scuola "Dalla parte dei bambini" di Napoli racconta la storia di Ugo Russo, quindicenne ucciso da un carabiniere durante una rapina che tentava di fare con un'arma giocattolo. Le voci degli studenti e delle studentesse, del fratello di Ugo, di Ascanio Celestini, danno vita a un racconto corale per condividere il dolore e riflettere sulla tragica morte di un ragazzo di 15 anni dei Quartieri Spagnoli di Napoli.

1. Matovičov vabank. 2. Pellegriniho agenti. 3. Prečo prezidentke klesá popularita.

Bentornati su Snap!Questa settimana abbiamo guardato il keynote Apple della WWDC 2002 dove ci hanno fatto vedere e raccontato cose®: ci vuole proprio un bel recap con l'occhio dell'architetto per capire cosa ci potrà tornar utile nel nostro lavoro!Noi architetti poi usiamo anche cose® per rilevare altre cose® con il LiDAR e creiamo ambienti con cose® al loro interno utilizzando il rendering in realtime per la progettazione.Buon ascolto!—>

Many thanks to my special guest today, Fil Strati of business IT support company, TechSeek.Where do you save your patient data to? How effective is your anti-virus?How secure is your data when you access your practice software remotely?This episode is such an important one to make sure you are structuring your technology systems in a secure, effective and compliant way.Go directly to Fil's website here: https://techseek.com.au/ If you have any feedback and requests for specific content, contact me at julie@julieparkerpractcesuccess.com.auHead over to our website at Julie Parker Practice Success and find loads of information that can help you and your practice be more successful.There are:Online Mini-CoursesFree DownloadsThe Club membership information and registrationProducts and aids for purchaseInterested in taking your personal, team, and dental practice to the next level? Contact Julie today to explore the possibilities for growth and success! Visit our website, Dental Business Mastery, at https://dentalbusinessmastery.com.au/, and book a complimentary, obligation-free Discovery Call to discuss your specific needs and goals. Schedule your call here: https://tidycal.com/3l298p1/30-minute-meeting Our website is also packed with valuable information, free tools, and resources to support you on your journey. Be sure to check it out! If you have any questions or would like more information, feel free to contact us via email at info@dentalbusinessmastery.com.au.

Ak niekedy mala maďarská opozícia šancu poraziť Orbána, je to teraz. Prieskumy sú takmer vyrovnané, ale množstvo voličov je ešte nerozhodnutých. Viktor Orbán má pred voľbami problémy, aké ešte nemal. Opozícia sa zjednotila proti nemu a do volieb postavila spoločnú kandidátku, na ktorej sú všetci od ľavicových zelených až po Jobbik. Fidesz je však momentálne ešte väčším extrémom ako Jobbik. Ako proruského Orbána ovplyvňuje vojna na Ukrajine? Čo by prípadná zmena vlády v Budapešti priniesla Slovensku a Európe? Odpovie politológ Zsolt Gál, ktorý je na Slovensku členom malej strany Maďarské fórum. Ako fungujú maďarské médiá a je nejaký rozdiel medzi proruskou a pro-Orbánovskou propagandou? Viac povie spolupracovník Aktualít, ktorý sa zaoberá aj maďarskou politikou, Zolo Mikeš. Ukážky zo zahraničného spravodajstva o Maďarsku, ktoré budete počuť v dnešnom podcaste, pochádzajú z BBC, Deutsche Welle, z francúzskej verejnoprávnej televízie a z Euronews. Moderuje Peter Hanák.

Štvrtok po Popolcovej strede. Káže br. Reginald OP. https://dominikani.sk/ podcast@dominikani.sk

Due tecniche bellissime su come gestire bene, anzi meglio, il tuo tempo quando devi studiare e lavorare contemporaneamente o hai tanti impegni.La prima si chiama tecnica degli Obiettivi Inversi e la seconda è la strategia di Studio a Strati.Il mio modo è questo, di certo ciascuno ha il proprio, quando vi va condividete anche le vostre tecniche.

1. Putin dostal jednoznačnú správu. Ako s ňou naloží? 2. Čo sa zmenilo za týždeň s omikronom. 3. Nemecko má novú vládu.

This week, Fr. Michael and Strati discuss St. Porphyrios, the modern elder and saint of modern day Greece, and read from his life with "Wounded by Love."★ Support this podcast on Patreon ★

In part one of this two-part ASCO Education Podcast episode, Dr. Sonali Smith (University of Chicago Medicine) and Dr. Paolo Strati (MD Anderson Cancer Center) discuss the application of recently approved therapies for diffuse large B-cell lymphoma through examination of challenging patient cases. Subscribe: Apple Podcasts, Google Podcasts | Additional resources: education.asco.org | Contact Us Air Date: 10/20/21   TRANSCRIPT [MUSIC PLAYING] SPEAKER: The purpose of this podcast is to educate and inform. This is not a substitute for medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. [MUSIC PLAYING] SONALI SMITH: Hello, and welcome to this episode of the ASCO Education Podcast highlighting new therapies for lymphoma. My name is Dr. Sonali Smith, and I'm a hematologist and medical oncologist specializing in lymphoma and clinical investigation in lymphoma. I'm also the Elwood V. Jensen Professor and chief of the hematology/oncology section at the University of Chicago, and very excited to be joined by my colleague, Dr. Paolo Strati. PAOLO STRATI: Good morning to everybody. My name is Paolo Strati. I'm a hematologist and medical oncologist and an assistant professor in the Department of Lymphoma/Myeloma, and in the Department of Translational Molecular Pathology at MD Anderson Cancer Center, Houston, Texas. And I'm also the clinical director for the Lymphma Tissue Bank. In part one of this podcast episode, we will discuss the adoption of recently approved therapies for diffuse large B-cell lymphoma, such as selinexor, tafasitamab, Liso-Cel, and Lonca-T. These therapies have transformed care for patients with this disease. And we'll start our conversation today with a patient case. SONALI SMITH: Great. Well, I'll go ahead and present a patient to you, Paulo. So this is a 78-year-old man with diffuse large B-cell lymphoma that is the germinal center-derived subtype. It is not double expressor, it is not double-hit. He has advanced stage disease with a high IPI, as well as the high CNS IPI. Luckily, his performance status is zero and he has no significant comorbidities or other health conditions. He received frontline dose-adjusted EPOC-R with intrathecal methotrexate for six cycles. But at the end, he had a partial remission. So how do you select your salvage therapy in this situation? Are you concerned about using agents targeting CD19 in the second line, given the potential need to use anti-CD19 cellular therapy, or CAR-T in the third line? PAOLO STRATI: This is a very interesting and unfortunately not uncommon case. And thank you, Sonali, for asking these very important questions. Technically, a platinum-based regimen followed by autologous transplant will be a standard answer and may be feasible. Because as you mentioned, this patient has a good performance status and non-meaningful comorbid health conditions. However, patients who are refractory to a frontline anthracycline-based regimen, such as in this case, with achievement only of partial remission at the end of frontline dose-adjusted EPOC, can potentially experience a suboptimal outcome following the standard approach with a platinum-based second line regimen. And as such, alternative strategies may be needed. To this regard, the combination of tafasitamab that, as you know, is a monoclonal antibody targeting CD19, and lenalidomide, an oral immunomodulatory agent, a combination which is currently approved by the FDA in the United States as a standard second line option for transplant ineligible patients, would be a great option in this case. Data from the three year follow-up of the phase II study that has brought to the FDA approval this combination, the L-MIND had been recently presented and have showed the complete remission rate of 40% and immediate duration of response of 44 months, including patients who received this regimen as a third line or beyond. So there is, of course, a biological concern by targeting CD19 in second line. These may potentially impact a third line use of an autologous anti-CD19 CAR-T, because CD19 downregulation may potentially be a mechanism of escape to tafasitamab. And recent data has shown the CD19 levels are strongly associated with the efficacy of CAR-T cell therapy in patients with large B-cell lymphoma. Small retrospective studies have shown that autologous anti-CD19 CAR-T can be safely and effectively used after antibodies or antibody drug conjugate targeting CD19. But we need a significantly larger and prospective data, including serial tissue biopsy in these patients before considering this combination as a standard practice in patients for whom we plan to use CAR-T as a third line. Until then, I would be cautious in using second line tafasitamab in patients, again, for whom there is a potential plan for anti-CD19 autologous CAR-T in third line. And if necessary, limited to very selective cases. Finally, recent press releases have anticipated the two autologous anti-CD19 CAR-T products, Axi-Cel and Liso-Cel, are superior to autologous settings transplanted in second line. And so in the near future, CAR-T cell therapy may become a standard second line option. And that would be an ideal option in primary chemorefractory patients as the case that you presented here. SONALI SMITH: Yeah, I agree. There are a tremendous number of options. And having anti-CD19 products as well as autologous stem cell transplant, the sequencing will be an evolution. So going back to this patient, he received tafasitamab and lenalidomide for two cycles with no significant toxicity, but unfortunately, he had further progression after two cycles based on a PET/CT scan. So what are your next steps? Would you move directly to an autologous anti-CD19 CAR-T cell therapy now? Would you re-biopsy before that? And how would you select among the three available CAR-T products? PAOLO STRATI: These are not easy questions, particularly the selection of one out of three available CAR-T products. As you said, there are currently three autologous anti-CD19 CAR-T products approved by the FDA in the United States for the treatment of large B-cell lymphoma in third line or beyond. And these are Axi-Cel, Tisa-Cel, and Liso-Cel. For all of them, the best outcome is observed for patients who have a low turmor burden at time of CAR-T infusion. And they need to either select patients with no bulky disease or to decrease it through bridging therapy. And as we define bridging therapy given between leukapharesis and CAR-T infusion. Unfortunately, there is currently no standard bridging therapy and all FDA products approved in third line can potentially be used in this specific scenario that you described, including polatuzumab with bendamustine/rituximab, selinexor, and Lonca-T, of course, beyond tafasitamab and len that has already been used in this case. Of course, when selecting a bridging therapy, there are many disease-related and patient-related factors to take into consideration, including the need to preserve the host immune microenvironment that we all know is crucial for the subsequent activity of CAR-T cells. And also, we need to give into consideration the need to preserve as much as possible, as we discussed previously, in CD19 expression. To this regard, and going back to one of your questions, I strongly recommend to re-biopsy patients if any bridging therapy is used between bridging therapy and CAR-T infusion in order to document CD19 expression before CAR-T infusion. When it comes to CAR-T product selection, as I said, it's a really difficult decision to do. And we don't have at this time randomized trials in third line. And as such, the decision is really left to the treating physician based on multiple factors. But all of the limitations of inter-study comparison, efficacy seems to be pretty much the same for the two products, maybe slightly higher based on the recent second line data. But Axi-Cel and Liso-Cel as compared to Tisa-Cel, and also as suggested by recent press release. However, due to the fact that Liso-Cel and Tisa-Cel have less potent co-stimulatory domain for 1BB instead of CD28, the rate of CRS and ICANS, the two main toxicities associated with CAR-T cell therapy, is usually lower with this to the point that some centers are able to infuse them in the outpatient setting, whereas Axi-Cel is almost always infused in the inpatient setting so the toxicity can be monitored more closely. So with older patients or those who have comorbid health condition, Tisa-Cel and Liso-Cel may be a safer option, though there's a lot of research going on trying to mitigate toxicities associated with Axi-Cel. Finally, it's important to keep in mind manufacturing time. Axi-Cel is manufactured in an average of 17 days, whereas Tisa-Cel and Liso-Cel take typically longer than three to four weeks. This can be itself a determining factor, particularly for patients who are quickly progressing and where immediate treatment is needed. SONALI SMITH: Yeah, I agree. I think there are going to be many patient product and disease-based factors that will impact both the effectiveness as well as the toxicity. And you did a really great job of explaining the role of the co-stimulatory domain potentially in some of that, as well as all of the products that are out there. It's definitely a complicated area. Going back to our patient, so he did undergo leukapharesis for Liso-Cel and received third line polatuzumab and rituximab without bendamustine. The restaging PET/CT after two cycles showed a PR with a significant decrease in tumor burden, and repeated biopsy showed high expression of CD19 by flow cytometry. He then proceeded with Liso-Cel, which was relatively well tolerated. There was only grade 1 cytokine release syndrome and no ICANS, so no neurotoxicity. And his day 30 PET/CT showed a complete remission. Unfortunately, the 90 day PET/CT showed progression. So Dr. Strati what is the outcome for patients who relapse after CAR-T? Do you recommend to re-biopsy? And what are the efficacy data for FDA approved agents for these patients? And I know this is a long question, but is there any role for repeated CAR-T or allogeneic transplant now? PAOLO STRATI: Unfortunately, currently, the outcome of patients with large B-cell lymphoma relapse or progress after autologous anti-CD19 CAR-T is suboptimal, with a life expectancy, unfortunately, shorter than six months. Hence, the need to be creative and customize treatment based on biological data. To this regard, I think it's crucial to repeat a tissue biopsy to guide subsequent therapy. As mentioned previously, there are currently four products approved by the FDA for patients with large B-cell lymphoma in third line and beyond. Two of these target CD19, tafasitamab plus lenalidomide and Lonca-T One targets CD79B, polatuzumab combined with bendamustine and rituximab. And one is an SPO1 inhibitor, selinexor. While we have no data for selinexor in patients who relapse or progress after CAR-T cell therapy, limited prospective data showed that a progression-free survival in the order of weeks is usually observed for patients who receive polatuzumab with or without bendamustine and rituximab after CAR-T cell therapy. So I would not recommend that. However, there's some interesting activity in the post-CAR-T setting for Lonca-T and for tafasitamab/len is limited to patients who still express CD19 in time of relapse. And of course, it needs to be largely and prospectively further investigated before becoming a standard approach for patients who relapse or progress after CAR-T cell therapy. When it comes to cellular therapy, repeated anti-CD19 CAR-T infusion is not shown to be successful in the original registration studies. So it is not currently something that I would recommend and is not definitely a common practice. And very limited retrospective studies have shown the use of allogeneic stem cell transplants in the post-CAR-T setting may be associated with quite elevated treatment-related mortality. So I don't suggest this as a standard practice in large B-cell lymphoma at this time. This is different from B acute lymphoblastic leukemia, where instead, allogeneic stem cell transplant is becoming progressively a standard approach. And we definitely need more data before using this consistently. While we strive to identify the optimal cell batch therapy for large B-cell lymphoma patients who relapse or progress after CAR-T cell therapy. I think the priority should be given to clinical trials, including CAR-T targeting molecules other than CD19, such as CD20, CD22, CD79B, allogeneic CAR-T there are immediately available, so without the need to wait for manufacturing times. And K-CAR, that may be less toxic than CAR-T and other non-cellular therapy biological agents. So definitely, clinical trials are, at this time, the best approach in patients who relapse after CAR-T cell therapy, as the case that you described. SONALI SMITH: Thank you Dr. Strati. As an update, this patient had repeated biopsy showing a CD19 positive relapse. He consented for a clinical trial with a novel NK-CAR targeting CD19, achieving CR which is still ongoing at nine months. And this case really does represent some of the most exciting advances that we've had for this disease for patients who can tolerate aggressive therapies and have access to clinical trials. PAOLO STRATI: Dr. Smith, I'd like to hear your opinion about another patient with diffuse large B-cell lymphoma. This patient is an 81-year-old man with a history of coronary artery disease and well-controlled diabetes mellitus, who noticed a right cervical lymph node while shaving that seemed to have popped up. He was evaluated by his primary care physician and given a course of antimicrobials. 10 days later, the lymphoma seems to be enlarging and he is referred to ENT pharyngeal biopsy. The specimen is small but shows follicular lymphoma in a portion of the sample. However, there is also concern for larger cells and possible transformation. The patient is also beginning to note night sweats and a decreased appetite. And labs are notable for elevated LDH, 500, and thrombocytopenia with a platelet count of 110. So Dr. Smith, in your opinion, is this specimen sufficient to start treatment? Or should treatment be delayed to get a larger and maybe excisional biopsy? SONALI SMITH: Yeah, thank you for this question. I think this is a challenge we have in the clinic all the time, which is what is a sufficient biopsy specimen to make a diagnosis that allows us to subtype lymphoma? As we know, every lymphoma subtype, the treatment is really guided by the histology and not so much the stage or some other factors. So having a needle biopsy is unfortunately often insufficient. In this case, we have a very strong concern for a possible transformation. And as we know, both follicular lymphoma and diffuse large B-cell lymphoma can mark very similarly when it comes to immunophenotype. Certainly, the germinal center type of diffuse large B-cell lymphoma or any transformed follicular lymphoma will be CD20 positive, CD10 positive, and it really requires architecture to be able to tell whether or not there are sheets of large cells. So the ideal outcome for this patient would be to have a biopsy that is done promptly that allows us not only to confirm whether or not there is histologic evidence of transformation, but also to conduct FISH studies to determine if there's acquisition of a MYC rearrangement. At its core, all follicular lymphoma patients essentially have a transformation of 14;18, leading to BCL2 rearrangement and BCL2 overexpression. During the transformation process, there can be an acquisition of a MYC rearrangement, which would then make this a double-hit lymphoma and certainly has a much worse prognosis and may also prompt a change in treatment if the patient can tolerate more intensive therapy. So my recommendation would be to have a biopsy. Now one other aspect is that sometimes, we don't really have the time to proceed with a biopsy, or the lymph node may be in an inaccessible area. And in that case, there are some other criteria that we can use to assume that somebody has a transformation. Symptoms such as profound B symptoms and elevated LDH, and sometimes, a PET scan with multiple areas of very high avidity, can lead you to feel or suggest that this person has a transformation. There is some controversy over the use of PET and we know it does not confirm a diagnosis of transformation. But in my opinion, this is very suggestive if there are many areas of high SUV. PAOLO STRATI: Thank you, Dr. Smith. I agree completely about the importance, when time allows, to perform either a larger core biopsy or an excisional biopsy, because as you very well-outlined, this has not just a mere diagnostic purpose, but can meaningfully affect treatment planning for patients. And actually, in this case, as you suggested, the patient eventually had multiple core biopsy that showed transformed follicular lymphoma with very evident areas of diffuse large B-cell lymphoma. FISH, as expected for follicular lymphoma, was positive for translocation for TN18, but luckily negative for MYC rearrangement. So fortunately, we didn't have to deal with a double-hit lymphoma. The remainder of his staging showed he had diffuse lymphadenopathy. And PET scan, as you mentioned, has a controversial role in the diagnosis of transformation. So there's some areas that had high avidity with an uptake with an SUV of 1215, whereas other areas were less intense with SUV 618. And usually, heterogeneity in SUV actually helps further supporting diagnosis or transformation. While meta-maps showed follicular lymphoma, no large cells. So movement was isolated in the B-cell lymphoma. So Dr. Smith, at this point, based on the provided information, what's your treatment approach in this older patient and also a patient with comorbid health conditions, but with diffuse large B-cell lymphoma? SONALI SMITH: Yes. The goal of treating any aggressive lymphoma is to obtain remission, and if the remission lasts, to hopefully offer cure to the patient. And when somebody has a transformed lymphoma, of course, there is a dual concern, which is that the aggressive component can potentially be put into remission in a durable way achieving cure. But the indolent component will always need to be monitored, although hopefully, will not be life threatening the way the aggressive component can be. Treating an octogenarian is really challenging, particularly due to comorbidities in this age group and the potential toxicity of chemotherapy. So the standard of care for diffuse large B-cell lymphoma is anthracycline-based chemotherapy. But this, of course, can have significant toxicity in older patients. And in addition, the vincristine can aggravate neuropathy. And I've personally found that the high dose steroids that are part of CHOP can also cause toxicity in older patients and patients who are frail. So unfortunately, the literature is somewhat sparse. But we do have several data sets that can guide management in this particular patient situation. The French published, over a decade ago, the development of R mini CHOP, that includes an attenuated dose of cyclophosphamide, doxorubicin, and vincristine, and leads to some durable remissions and cure. Unfortunately, the long-term overall survival is less than 50% with R mini CHOP. And so although this is an appropriate backbone, there's certainly a lot of room for improvement. And there's also toxicity even with R mini CHOP. So in their initial phase II trial, there was actual deaths related to the R mini CHOP, particularly in the first cycle or two, really necessitating some type of pre-phase help ease patients into the chemotherapy. One of the challenges that we face in the clinic is that when we meet an older patient, we both want to maximize our chance for cure, but also minimize the toxicity that is particularly pronounced. And there is very little data in terms of how to guide this at the bedside. I'm excited that SWOG, with the US Intergroup, is conducting a trial, S1918, which prospectively includes a frailty assessment tool that was developed by the Italian group in lymphoma, and then also includes serial comprehensive geriatric assessment so that we can get a better idea about quality of life both during and after treatment. So there is no great standard of care right now, but I would say that R mini CHOP, outside of a trial, is a very reasonable way to proceed. PAOLO STRATI: Dr. Smith, thank you for outlining so well what we can do to minimize toxicity and to better select patients for this type of treatment. And as an Italian practitioner in the United States, I am very excited that the Italian frailty tool will be used in this SWOG trial. Are there any other ways to further improve safety when we use chemo immunotherapy in older patients or patients with comorbid health conditions? In particular, there is a lot of concern about potentially infectious complications in these patients. And so I'm wondering if there's any routine antimicrobial prophylaxis that you recommend. SONALI SMITH: Yes. I think it's really important to maximize supportive care for our older patients with aggressive lymphomas getting intensive therapy. I did mention the pre-phase, and I would just like to mention that one more time because I do think there's data that providing a brief pre-phase can minimize toxicity with the first cycle. And how this pre-phase is given is highly variable. Again, the data is somewhat limited, but it typically includes steroids given for five to seven days with or without a dose of vincristine. And steroids themselves can have toxicity. And the dose of the steroids, I think, is somewhat controversial. In my personal practice, I use somewhere between 40 to 60 milligrams per day for five to seven days. And I do not typically use vincristine, although a prospective French trial recently did and showed that this significantly improved toxicity. Other complications that can occur really are related to infection. And so, of course, all patients should have growth factor support as per ASCO guidelines. But I also routinely give VZV prophylaxis with acyclovir or valacyclovir. And for the first cycle in particular, I have patients come back to clinic after the first dose one week later to ensure that the counts are stable and that they are doing well. This is really where our team of nurses and other providers who are part of the care team are so important and communication is also very important. PAOLO STRATI: So Dr. Smith, as you suggested, also, this patient actually received mini R-CHOP without any complications. And end-of-treatment PET/CT can showed a VL score of 3, so a complete metabolic remission, potentially. How do you interpret these findings? SONALI SMITH: So response criteria in clinical trials, and then of course, extrapolated to the clinic, have evolved in lymphoma. And the Deauville or the International Prognostic Scoring System that has been used typically defines a uptake relative to liver and mediastinal blood pool. And those patients who have a Deauville 1 to 2, which is less than that bar, is considered negative. And 4 to 5 is positive, with five being the emergence of new sites of adenopathy. The interpretation of a Deauville 3 can be somewhat more complicated, but this really outlines the limitations of just using the SUV or the PET scan uptake to measure response. For my patient and for this patient, the lymph nodes all substantially decreased in size. And having some type of combined interpretation of the uptake, as well as the size that has decreased, I think is going to be a very important part of how we approach patients going forward. So for this patient, I opted for close observation after the completion of therapy and felt that his Deauville 3, along with the decrease in the size of the lymph nodes, was very significant. PAOLO STRATI: I completely agree with that. Where PET scan is an extremely helpful tool, particularly for the management of aggressive B-cell lymphoma, can also become a major challenge when it comes to its interpretation for these borderline scenarios. And as you said, it's very important to add into the equation multiple parameters, including CT findings and overall patient performance status symptoms. So that's all we have for today. Thank you, Dr. Smith. This was a great conversation. We have learned and discussed a lot about diffuse large B-cell lymphoma, including novel biological agents, CAR-T cell therapy, management of elderly patients, and patients with comorbid health conditions and interpretation of PET/CT scan. I think this will be very helpful. And the conversation will continue beyond this podcast. In part 2 of this episode, airing in November, we will discuss new therapies for mantle cell lymphoma and for follicular lymphoma. Thank you so much to all the listeners tuning into this episode of the ASCO Educational Podcast. SONALI SMITH: Thank you. It's been a pleasure to speak with you today. [MUSIC PLAYING] SPEAKER: Thank you for listening to this week's episode of the ASCO e-learning weekly podcast. To make us part of your weekly routine, click Subscribe. Let us know what you think by leaving a review. For more information, visit the comprehensive e-learning center at elearning.asco.org.

In questo episodio parliamo di: - Autunno in Italia: cosa vuol dire “andare a funghi/andare per funghi”? - Dove e come si cercano i funghi e quali sono i segreti per trovarli! - I funghi più amati in Italia: i porcini - Cucinare i funghi: i piatti più buoni! Parole utili: - Cesta: cesta / basket - Strati: camadas / layers - Castagno: castanheiro / chestnut tree - Posto: lugar /place I piatti di cui vi parlo sono: risotto con i funghi, funghi trifolati, funghi fritti, funghi in insalata con olio e limone. Qui il link all'episodio dedicato al tartufo: https://anchor.fm/italianoconamore/episodes/9--Loro-in-Cucina-Il-Tartufo-elalej Domande? Scrivete qui: Contatto – Italiano con Amore Parliamo su instagram: https://www.instagram.com/italianoconamore/ Stanno arrivando i corsi di Italiano con Amore! Dettagli qui: https://italianoconamore.com/corsi/ 53. Vida na Itália: Procurando Cogumelos! Neste episódio, falamos sobre: - Outono na Itália: o que significa “andare a funghi" / "andare per funghi”? - Onde e como procurar cogumelos e quais são os segredos para encontrá-los! - Os cogumelos mais amados na Itália: porcini - Cozinhar cogumelos: os melhores pratos! Palavras úteis: - Cesta: cesta / basket - Strati: camadas / layers - Castagno: castanheiro / chestnut tree - Posto: lugar /place Os pratos de que falo são: risoto com cogumelos, cogumelos salteados, cogumelos fritos, cogumelos em saladas com azeite e limão. Aqui está o link para o episódio dedicado à trufa: https://anchor.fm/italianoconamore/episodes/9--Loro-in-Cucina-Il-Tartufo-elalej Perguntas? Escreva aqui: Contatto – Italiano con Amore Nos falamos no instagram https://www.instagram.com/italianoconamore/ Estão chegando os cursos de Italiano Con Amore! Detalhes aqui: https://italianoconamore.com/pt/corsi/

Mike has made a tremendous impact on how Trake adapts his coaching style to meet the needs of each individual player. In this episode, Mike and Trake share some strategies on how they have used Culture Index to produce tremendous results for players and teams in a short amount of time. You can learn more about Culture Index here. Connect with Trake on Twitter and Instagram @trakecarpenter. Subscribe & leave a review wherever you listen to your podcasts!

Narodil sa skoro dva roky od titulu hokejových majstrov sveta v Göteborgu. Natoľko zaujal kapitána vtedajšieho tímu Miroslava Šatana i súčasného kouča Craiga Ramsayho, že ho v 17 rokoch čaká druhý dôležitý turnaj v drese reprezentačného áčka. Hosťom Fair Play bol Šimon Nemec, supertalent slovenského hokeja.

Rôzne otázky, rôzni pastori, odpovede na pár minút. Monika Gurková nás sprevádza reláciou Navigácia na ceste, v ktorej dôležité témy rozoberajú pastori (Stano Gurka, Ivan Zuštiak, Pavel Hanes, Michal Findra a Samuel Javornický).

The How I Built My Business Podcast welcomes, Strati Vourakis, Founder & President of Calm Computing. Strati tells us what it takes to run a successful business for 12 years including all the ups and downs. He gives some extremely valuable advice about the IT risk of employees working from home without the right precautions. Dave learns that he can send text messages with embedded fireworks graphics. The future is here! This podcast is brought to you by Carlsen O'Connell Commercial Real Estate. They help companies find office space to rent and commercial buildings to buy. Need help with commercial real estate? Go to www.CarlsenOConnell.com for more information.

If you're a fan of Trisagion Films, this one is for you. This week, Dave sits down with Strati Papageorgiou, the Founder, Director and Editor of Trisagion Films. Strati tells Dave how Trisagion started and how they pick the saints they cover. He also shares some insights on growing up with a father who was a trained theologian and priest in the Orthodox faith. While not a father himself, you won't want to miss the lessons he shares for dads from the life of St. Anthony. All of that and more in episode #51 of Dad Devotionals! Also, don't miss Orthodox@Work-- my new monthly podcast series with Sean Reid, an Orthodox deacon and business coach. It starts on next Monday -- June 29, 2020 -- and will run on the last Monday of each month. We will discuss how to live out Orthodoxy in the workplace and your business. Want to support Dad Devotionals' mission? You can by becoming a Patreon supporter. Please check consider starting your monthly contribution at https://patreon.com/DadDevotionals. --- Send in a voice message: https://anchor.fm/david-domzalski/message Support this podcast: https://anchor.fm/david-domzalski/support

Ak sa okamžite nezníži alebo nezastaví produkcia CO2, naše deti budú vyrastať na inej planéte ako my. Na svete hrozí vyhynutie až jednému miliónu druhov živočíchov a rastlín do roku 2050. Aj keď má planéta svoje vlastné prirodzené zmeny klímy, vieme s istotou povedať, že konkrétne túto katastrofu spôsobil alebo spôsobí človek. Stratiť sa môžu mnohé obojživelníky, koraly, a až tretina morských cicavcov. "Môžeme očakávať, že najbližšie desaťročia sa začne pre zmenu klímy sťahovať až pol miliarda ľudí. Pôjdu na sever, teda na Sibír, do Severnej Ameriky alebo do Európy," hovorí klimatológ Milan Lapin. Ak chcete vy osobne prispieť k zmierneniu dopadov klimatickej zmeny, nakupujte lokálne produkty, jedzte menej ryže a mäsa, dodáva klimatológ. Vypočujte si prognózu planéty Zem od klimatológa Lapina v rozhovore so Zuzanou Kovačič Hanzelovou.

In this episode Kimberly interviews her client, the director of ops of Yoga Sports Science, Bonnie Strati, on how she moved from being a self-proclaimed "mess" post-divorce to growing a million-dollar, worldwide yoga training company in the science of elite performance for athletes. OMG this episode is filled with soooo many amazing gems. You'll discover: why understanding the anatomy and biomechanics of yoga is essential for working with elite athletes (and dangerous for your clients if you don't have that knowledge) (11:00), how perspective, habits, and perseverance are key to getting out of your own way (18:00), why you MUST celebrate the small success and be okay with starting where you are (33:00), how to build the tools to be resilient in your life, so a bad-day doesn't turn into a bad-week (44:00), what being vulnerable has to do with being powerful (45:00), and why Bonnie would have NEVER come onto the podcast a year ago (1:03:00). If you're a yoga instructor, personal trainer, physical therapist, Pilates instructor, or fitness instructor, check out the Institute of Yoga Sports Science to enhance your knowledge, so you too can hone your craft and take high performing athletes to their next level: https://www.yogasportscience.com/ Want to advance your physical performance with Bonnie? Sign up to work with her for your body's needs here: https://www.bonniestrati.com/ If you too in a massive transition in your life - divorce, changing careers, becoming a mother - and need more personal attention, for $147, you can book a 90-Minute 1:1 consult call with Kimberly. On this call, you'll receive at least 5 actionable strategies you can put into place, immediately to give you more clarity, energy, productivity, courage, and influence as you shift to your next level. APPLY NOW FOR YOUR CONSULT. Struggling as a coach and you want to get your business off the ground, jump into Kimberly's VIP monthly membership, The Princess Process, to get weekly group training and laser coaching for your business' needs, so you start making the income and impact you deserve. JOIN THE MEMBERSHIP HERE. Thank you so much for tuning in! Please leave a review on iTunes so we can keep the magic coming your way! For more biz inspo + mindset tools, follow us on Instagram: @crownyourself.now Follow my own mompreneur journey to #CrownYourself on Instagram: @kimberly.spencer Join the Facebook Group: "Crown Yourself Coaching" For more mindset, motivation, actionable strategies, and business-building tips, check out: crownyourself.com