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Sono giorni, questi, in cui si va nei cimiteri che sono luoghi di incontri, di ricordi, di curiosità e anche di scoperte e conoscenze storiche tanto che vi sono molte persone che durante i loro viaggi fanno visita ai campisanti in quello che viene definito “cimiturismo”.Numerosi artisti, scrittori e scienziati hanno scelto il Ticino come luogo di vita, di lavoro e di riposo: le loro tombe, ancora oggi visitate, testimoniano il loro legame con la regione. Mare Dignola, autore del libro Incontri tra i cipressi del Ticino, racconta queste sorprendenti presenze nei cimiteri ticinesi. Douglas Sirk a Castagnola, Hermann Hesse a Gentilino, Arturo Benedetti Michelangeli a Pura, Alfredo Foni a Breganzona, Paulette Goddard e Erich Maria Remarque a Ronco sopra Ascona, Alessandro Moissi a Morcote, Gisela Andersch a Berzona, Cesare Thomson a Lugano, Jean Arp a Locarno e l'elenco potrebbe continuare. Sono artisti, scrittori, scienziati che hanno vissuto in Ticino e hanno scelto di rimanere da noi anche dopo la morte. Parecchi di loro hanno vissuto con discrezione nei nostri Comuni. Ma le loro tombe, anche in piccoli cimiteri, ci ricordano il loro vissuto, le loro opere, la loro presenza. Altri hanno raccolto consensi internazionali e, ancora oggi, le loro tombe sono meta di visite di estimatori.Dai cimiteri della Svizzera italiana ai piccoli cimiteri italiani di cui si è occupato, Claudio Visentin che ha scritto un libro “Passeggiate nei piccoli cimiteri” per riflettere sul tempo, sulla morte e sulla vita. La commozione per una persona cara, l'empatia per uno sconosciuto, la curiosità per una frase, una scritta, un epitaffio o una fotografia su una lapide o su una tomba. Andar per piccoli cimiteri consente di immergersi in un silenzio diverso, vuoto eppure pieno. Chi ha tracciato i sentieri e le strade? I morti. Chi ha dato il nome ai paesi? I morti. Chi ha costruito le case e le chiese? I morti. Chi ha disegnato le forme dei campi registrate nel catasto? I morti. Chi ha stabilito leggi, regole di convivenza, usi e costumi quotidiani? I morti. Nei piccoli cimiteri di campagna e di paese, e ancora più nei poetici cimiteri abbandonati, specie lungo tutto l'Appennino, i morti sembrano più presenti dei vivi; la morte fa meno paura, il dialogo fra le generazioni passate e presenti si mantiene a lungo e ogni cimitero ha una storia da raccontare. Dai cimiteri al significato odierno della festa di Ognissanti e della commemorazioni di tutti i defunti con uno sguardo antropologico: se la morte è certa, il modo di affrontarla è un tema dei vivi e, in quanto tale, muta a seconda dei contesti, delle culture, delle tradizioni e delle usanze dei singoli Paesi. L'antropologia ci insegna che sono molti e diversi i modi in cui le comunità affrontano l'esperienza universale della morte. L'idea di ricordare in un'unica ricorrenza tutti i morti risale al secolo IX grazie all'abate benedettino sant'Odilone di Cluny. Il significato è quello di pregare per le anime di tutti coloro che ci hanno preceduti nel segno della fede e si sono addormentati nella speranza della resurrezione e per tutti coloro dei quali solo Dio ha conosciuto la fede. I primi giorni d'autunno, dunque, per chi sa guardare e ascoltare sono l'occasione per andare dentro e oltre le storie di famiglie e di personaggi, più o meno famosi o più o meno sconosciuti, i cui nomi e cognomi si ritrovano anche nei cimiteri, appezzamenti di terra molto concreti ma allo stesso tempo carichi di simboli e significati su paesi, comunità e persone.Sono ospiti:Sara Zambotti, giornalista della RAI e docente di antropologia al Politecnico di Milano,Mare Dignola, autore del libro “ncontri tra i cipressi del Ticino (Fontana Editore, 2024),Claudio Visentin, autore del libro Passeggiate nei piccoli cimiteri (Ediciclo Editore, 2023), docente di Storia del turismo all'Università della Svizzera italiana, scrittore e saggista.
Trump encontra Xi Jinping na quinta-feira. Muita água passou debaixo das pontes, desde que, entre 1950 e 1953, EUA e China se enfrentaram em batalhas terríveis, na Guerra da Coreia, onde se cumprimentarão agora. O encontro dar-se-á de manhã, nos arredores da cidade de Gyeongju, no centro-sudeste da Coreia do Sul, a 370 km de Seul, e que foi a capital de um império mítico, Silla, que dominou grande parte da actual Coreia do Sul até ao século IX. Ouça o comentário de Nuno Rogeiro na versão podcasts do programa Jogos de Poder, emitido na SIC a 28 de outubro. Para ver a versão vídeo deste episódio, clique aquiSee omnystudio.com/listener for privacy information.
Określenie Praga Magiczna, używane często w odniesieniu do stolicy Czech, ma wiele różnych źródeł. Gdyby szukać jednego, dominującego nad innymi, to byłyby to czasy przełomu XVI i XVII wieku, czasy, określane - od imienia panującego wówczas z tego miasta władcy, epoką rudolfińską.Cesarz Rudolf II Habsburg nie tylko przeniósł z Wiednia do Pragi stolicę swojego imperium. On także uczynił miasto nad Wełtawą ówczesną stolicą sztuk i nauk - więc, bo mówimy o czasach przełomu renesansu i baroku, magii. Cesarski dwór ściągał do siebie jak magnes najwybitniejszych malarzy i rzeźbiarzy epoki, pupilami wychowanego w Hiszpanii władcy stawali się astronomowie, astrolodzy, chemicy i zwykli szarlatani. Jedni szukali kamienia filozoficznego, inni układali skoplikowane horoskopy. Czasem - jak Johanes Kepler, odkrywając obowiązujące do dziś prawa, rządzące ruchem planet.Cesarz zgromadził też największe w ówczesnej Europie zbiory sztuki i różnej maści kuriozów. A by je wszystkie odpowiednio wyeksponować, zasadniczo przebudował i rozbudował zamek na Hradczanach. Materialne dziedzictwo Habsburga - tysiące płócien, grafik, okazów i machin jako całość przetrwało Rudolfa II o raptem kilka lat. Cesarz był bowiem równocześnie władcą wspaniałym i beznadziejnym. 30 lat jego rządów rozchwiało złożoną etniczną i religijną układankę imperium Habsburgów i przyczyniło się w znacznym stopniu do koszmaru Wojny Trzydziestoletniej. Ale chociaż zbiorów cesarza artystów i alchemików w większości nie ma już na zamku na Hradczanach, to duch Pragi Magicznej, dziedzictwo czasów, gdy miasto ostatni raz było stolicą cesarstwa, wciąż można w nim poczuć.***Jeśli podcast Wam się podoba i chcecie pomóc go rozwijać, możecie zostać Patronami lub Patronkami Czechostacji w serwisie Patronite. W tym tygodniu zdecydowali się na to:Grzegorz, Jacek, LenaBardzo Wam dziękuję
Welcome back to the Star Wars Escape Pod! Join your hosts Josh and Blake (with a pop-in from Darian) as they break down the biggest news from the Lucasfilm publishing panel at New York Comic Con (NYCC). They dive deep into the newly announced Star Wars: Legacy novel, which sends Rey and her new master, Leia Organa, on a quest to fix the Skywalker lightsaber between Episode VIII and IX. Plus, they cover a new Young Adult romance book, the latest Mandalorian art book, and the announcement of a Star Wars Visions manga. EMAIL US YOUR REQUESTS AND QUESTIONS! ———————————————————————— Have you checked out our flashcast called Star Wars Launch Pad? https://www.youtube.com/@SWLaunchPad https://open.spotify.com/show/1v0naAAJZMW0nig3OkFToJ?si=8014aef1647f4da5 Found on any platform in the galaxy! ———————————————————————— Star Wars Escape Pod
¡Vótame en los Premios iVoox 2025! Agradece a este podcast tantas horas de entretenimiento y disfruta de episodios exclusivos como éste. ¡Apóyale en iVoox! Desde Bagdad y la Casa de la Sabiduría, en el siglo IX; hasta el observatorio de Samarcanda y Ulugh Beg, hay muchas figuras e historias interesantes que nos ayudan a seguir en nuestro viaje por la historia de la astronomía. Un viaje que nos llevará a recorrer algunos de los lugares más importantes de los siglos IX a XV y prepara el terreno para hablar de la astronomía de Al-Andalus... Música: Epidemic Sound Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals
https://www.patreon.com/isyanderandkoda You already know how to please the Machine Gods at this point so thank you so much. And make your voices heard for which faction you would like to see next! -Isyander P.s for those of you who want to send stuff our way. Thank you in advance. Po BoxIsyander & Koda Po Box 1196, Tacoma, Wa, 98402, USAAnything below is made for (and by) the omnissiah. You can read it though, just a summary of the banger of a video you're watching.Today we're diving deep into the ever-shifting madness of the Lords of Change, the Greater Daemons of Tzeentch, the Changer of Ways. From their uncanny intelligence and spell-slinging dominance to their tendency to unravel fate itself just for a laugh — these birdlike horrors are the very embodiment of chaos, deception, and sorcery in Warhammer 40K.We'll cover their connection to Tzeentch's labyrinthine mind, their terrifying presence on the battlefield, and why staring into their eyes might just make you lose yours. From Kairos Fateweaver to Aetaos'rau'keres, we're peeling back the shimmering layers of madness to see what makes these feathered nightmares tick.So grab your psyker wards, keep your eyes down, and let's explore the brilliant insanity that is the Lords of Change.———TAGSWarhammer 40K, Warhammer 40K lore, Warhammer 40K explained, Warhammer 40K universe, Warhammer 40K chaos, Warhammer 40K chaos gods, Warhammer 40K daemons, Chaos Daemons, Chaos Gods, Tzeentch, Tzeentch lore, Lords of Change, Lord of Change, Greater Daemons of Tzeentch, Kairos Fateweaver, Aetaos'rau'keres, Ix'thar'ganix, Eye of Tzeentch, Changer of Ways, Warhammer fantasy, Warhammer chaos faction, Warhammer lore explained, Warhammer lore deep dive, Warhammer 40K story, Warhammer 40K deep dive, Warhammer 40K analysis, Warhammer 40K chaos lore, Warhammer 40K daemons explained, 40K demons explained, 40K chaos gods, Warhammer 40K Tzeentch lore, Tzeentch explained, 40K greater daemons, Warhammer chaos demons, Warhammer 40K chaos explained, Warhammer universe explained, grimdark universe, grimdark lore, grimdark explanation, the warp explained, warp lore, daemonology, 40K daemonology, 40K magic, chaos magic, sorcery in 40K, psychic powers 40K, 40K psykers, Magnus the Red, Thousand Sons, Book of Magnus, Horus Heresy, 40K heresy lore, chaos corruption, corruption in 40K, 40K chaos powers, warp entities, warp creatures, chaos realm, realm of chaos, Warhammer 40K history, 40K history, 40K theory, Warhammer theory, Warhammer fan theory, Warhammer lore video, Warhammer lore channel, Warhammer 40K video essay, Warhammer 40K content, Tzeentch greater daemon, Changer of Ways explained, eye of Tzeentch lore, chaos sorcerer, chaos wizard, chaos schemer, fateweaver, warp entities explained, lore of chaos, warhammer tzeentch video, tzeentch greater demon, chaos greater demons, warhammer deep dive, warhammer chaos explained, warhammer lore discussion, 40k lore talk, warhammer daemons of chaos, daemons of chaos explained, chaos bird demon, bird demon warhammer, chaos lore explained, chaos story, tzeentchian lore, chaos sorcery, warhammer grimdark, grimdark science fiction, 40k storytelling, tzeentch daemon prince, warhammer 40k chaos powers, 40k chaos gods explained, warhammer chaos video, lore deep dive, tzeentch warhammer lore, chaos gods deep dive, fateweaver explained, kairos explained, 40k lore explained, tzeentch chaos magic, greater daemons explained, 40k warp entities, changer of ways explained, warp storms, 40k demons————————————Opinions expressed in this video are solely those of Isyander & Koda and in no way reflect the views or opinions of Games Workshop Ltd.Artwork throughout this video is used for educational purposes. if you see your artwork and would like an art credit, message me.Support the show
The Current Moment Episode 8: The Superlative Episode ft Kathleen Gier Welcome to Episode 8 of The Current Moment, where we keep you current on all things KC Current. In this episode, ThomBomb is joined by Kathleen Gier of The Equalizer, The Next and The IX. After the pair recap Current's latest match against Gotham, they go into season superlatives for Shield winners. Categories include best attacker, midfielder, and defender as well as top result of the season and most impressive record broken this season. The pair then give some analysis for Current's upcoming trip to Houston Dash. Be sure to follow Kathleen on BlueSky at @kgier.bsky.social to follow more of her work.
In Teil 4 unserer Serie über Aleister Crowley begleiten wir die „Große Bestie“ auf ihrem Weg von London über New York bis nach Sizilien.Wir erzählen, wie Crowley Telema in die Praxis umsetzt, seine Do-it-Yourself-Orden gründet, Sexualmagie systematisiert und mit Theodor Reuss den OTO reformiert. In der „Abtei von Thelema“ auf Sizilien lebt er mit seinen Schülern und Geliebten eine radikale Form spiritueller und sexueller Freiheit – bis Hygiene, Drogen und Tod das Experiment beenden. Eine Episode über Vision und Wahnsinn, über Freiheit und Manipulation und darüber, wie aus dem okkulten Rebellen eine Skandalfigur wurde, die noch heute fasziniert.#AleisterCrowley #Thelema #Magie #Okkultismus #Geschichte---Youtube-Kanalmitglied werden und exklusive Vorteile erhalten: https://www.youtube.com/channel/UC8d09rKkWS5MkIdAuzUpkmA/joinDir gefällt der Podcast? Dann kannst du uns gerne auf Patreon unterstützen: https://www.patreon.com/allezeitderweltWir würden uns ebenfalls riesig darüber freuen, wenn du uns eine Bewertung hinterlässt und uns auf YouTube (https://www.youtube.com/@allezeitderwelt) folgst!Danke für deine Unterstützung!---Quellen & Literatur:Perdurabo: The Life of Aleister Crowley by Richard KaczynskiCrowley, Aleister: The Book of the Law (Liber AL vel Legis). London 1904.Crowley, Aleister: The Equinox: The Review of Scientific Illuminism. Vol. I–X, London 1909–1919.Crowley, Aleister: The Confessions of Aleister Crowley: An Autohagiography. London 1929.Crowley, Aleister: Magick in Theory and Practice. London 1929–1930.Crowley, Aleister: The Book of Lies. London 1913.
Miesiąc temu do księgarń trafiła książka "Dobrý den. Chmiel, tożsamość i luz. Polskie mity o Czechach". Tak się składa, że jestem autorem tej wydanej przez Wydawnictwo Mando pozycji. I że wyrasta ona z Czechostacji, z tych snutych przeze mnie od dwóch lat, już bez mała stu opowieści, w których staram się Wam przybliżać Czechy.Ten odcinek jest pewną formą spotkania autorskiego dla tych z Was, którzy książkę czytali a z którymi nie mam jak się spotkać osobiście. Mam też oczywiście nadzieję, że ci co nie czytali, ba - dopiero teraz dowiadują się, że taka książka jest, może się nią po tej rozmowie zainteresują.W kwestiach technicznych - rozmowa jest zapisem spotkania autorskiego, które odbyło się 17 października 2025 roku w Faktycznym Domu Kultury w Warszawie. Rozmowę ze mną poprowadziła prof. Karolina Ćwiek-Rogalska z Instytutu Slawistyki Polskiej Akademii Nauk, co jest, na jakimś poziomie, o tyle zabawne - że tym razem zamieniliśmy się rolami; zwykle to Karolina jest zapraszaną do Czechostacji ekspertką.Jeśli chodzi o samą rozmowę - dużo w niej oczywiście o książce, równocześnie jednak byliśmy na tyle sprytni, że jeśli to kogoś zaciekawiło, to nadal znajdzie w niej całkiem sporo rzeczy, o ktorych nie rozmawialiśmy w ogóle ;) Ale jest np. całkiem sporo o tym, dlaczego polski śmieszy Czechów a czeski Polaków i czemu interpretowanie historii innego kraju przez pryzmat dziejów własnej ojczyzny zwykle sprowadzi nas na manowce. Oraz - całkiem sporo, o lenistwie jako motorze napędowym do napisania książki na pół miliona znaków.***Jeśli podcast Wam się podoba i chcecie pomóc go rozwijać, możecie zostać Patronami lub Patronkami Czechostacji w serwisie Patronite. W tym tygodniu zdecydowali się na to:Aneta, Filip, Maciej, Magda, Mateusz, Natalia i PiotrBardzo Wam dziękuję
Dans son ouvrage «Écrire le français», Gabriella Parussa retrace l'histoire de l'écrit de la langue française, et son évolution. Comment le français est-il devenu une langue écrite ? Le français fut tout d'abord une langue orale, une langue parlée, une langue de la communication, alors que la langue écrite, celle de la culture, de la justice, de l'administration, était le latin. Le français a beaucoup évolué, tant au niveau de la phonétique qu'au niveau de la syntaxe et la morphologie. Les premiers textes (rarissimes) écrits en français remontent à la deuxième partie du IXè siècle. C'est l'alphabet latin qui est utilisé pour «transférer» cette langue de l'oral à l'écrit, mais Il faut faire des ajustements, car l'alphabet latin n'est pas parfait et ne permet pas de restituer tous les sons… Il y a alors vingt-trois lettres dans l'alphabet latin. Le passage à l'écrit s'est fait avec la volonté de conserver la mémoire. Les premiers «livres» s'écrivaient grâce à des copistes ; cela pouvait prendre des mois. L'écriture : comme une «peinture de la voix» En 842, les petits-fils de Charlemagne signent une alliance militaire : les serments de Strasbourg, Nithard écrit alors en ce qu'on appelle «le proto français» : un mélange entre le latin tardif et le français. C'est l'un des premiers textes conservés avec des traces de français écrit. «C'est une étape importante, on écrit dans les deux langues vernaculaires de l'époque». Ils écrivent cette nouvelle langue en «écoutant». «On dira que l'écriture doit être comme une peinture de la voix, doit correspondre à ce que l'on dit, ce qu'on prononce». Le français est alors très mouvant : on ne parle pas et on n'écrit pas de la même manière selon qu'on habite Arras ou Lyon. Mais les choses vont se fixer avec l'invention de l'imprimerie puis des premières grammaires écrites. Les variations vont alors s'estomper peu à peu. Les imprimeurs vont alors jouer un rôle très important dans la standardisation pour que le livre qu'ils diffusent soit lu et compris et plus grand nombre. Les graphies régionales vont alors peu à peu disparaître. À lire : Bernard Cerquiglini, auteur de L'invention de Nithard aux éditions de Minuit. Invitée : Gabriella Parussa, spécialiste de l'histoire de la langue française, est professeure de linguistique et philologie à la Faculté des Lettres – Sorbonne Université. Ses travaux portent sur le code écrit et son histoire des origines à nos jours. Son ouvrage «Écrire le français, toute une histoire» est publié aux éditions Actes Sud. Dans la chronique Ailleurs, nous parlerons du Festival Beyrouth Livres qui aura lieu dans la capitale libanaise, du 22 au 26 octobre 2025. Et c'est Sarra Ghorbal, attachée pour le livre et le débat d'idées et co-commissaire générale du festival Beyrouth livres qui nous parle de l'évènement. Programmation musicale : Le collectif musical Lamomali avec le titre Totem.
Mark and Alex are back with a fresh start in the next Final Fantasy series title, Final Fantasy XII: The Zodiac Age! This is by far one of the boys' favorite RPG's, and the story begins by laying the groundwork of a power struggle between civilizations. Many new faces are introduced and new systems need to be learned as this title is quite different than all of the previous Final Fantasy games. After meeting the main protagonist, Vaan, the boys worked their way through the story and take on the first hunt, Hunt No. 01: Rogue Tomato.If you're searching for the beginning of the Final Fantasy X or IX series, check the quick info below!Start of the Final Fantasy X series is episode 43Start of the Final Fantasy IX series is episodes 6
Dans son ouvrage «Écrire le français», Gabriella Parussa retrace l'histoire de l'écrit de la langue française, et son évolution. Comment le français est-il devenu une langue écrite ? Le français fut tout d'abord une langue orale, une langue parlée, une langue de la communication, alors que la langue écrite, celle de la culture, de la justice, de l'administration, était le latin. Le français a beaucoup évolué, tant au niveau de la phonétique qu'au niveau de la syntaxe et la morphologie. Les premiers textes (rarissimes) écrits en français remontent à la deuxième partie du IXè siècle. C'est l'alphabet latin qui est utilisé pour «transférer» cette langue de l'oral à l'écrit, mais Il faut faire des ajustements, car l'alphabet latin n'est pas parfait et ne permet pas de restituer tous les sons… Il y a alors vingt-trois lettres dans l'alphabet latin. Le passage à l'écrit s'est fait avec la volonté de conserver la mémoire. Les premiers «livres» s'écrivaient grâce à des copistes ; cela pouvait prendre des mois. L'écriture : comme une «peinture de la voix» En 842, les petits-fils de Charlemagne signent une alliance militaire : les serments de Strasbourg, Nithard écrit alors en ce qu'on appelle «le proto français» : un mélange entre le latin tardif et le français. C'est l'un des premiers textes conservés avec des traces de français écrit. «C'est une étape importante, on écrit dans les deux langues vernaculaires de l'époque». Ils écrivent cette nouvelle langue en «écoutant». «On dira que l'écriture doit être comme une peinture de la voix, doit correspondre à ce que l'on dit, ce qu'on prononce». Le français est alors très mouvant : on ne parle pas et on n'écrit pas de la même manière selon qu'on habite Arras ou Lyon. Mais les choses vont se fixer avec l'invention de l'imprimerie puis des premières grammaires écrites. Les variations vont alors s'estomper peu à peu. Les imprimeurs vont alors jouer un rôle très important dans la standardisation pour que le livre qu'ils diffusent soit lu et compris et plus grand nombre. Les graphies régionales vont alors peu à peu disparaître. À lire : Bernard Cerquiglini, auteur de L'invention de Nithard aux éditions de Minuit. Invitée : Gabriella Parussa, spécialiste de l'histoire de la langue française, est professeure de linguistique et philologie à la Faculté des Lettres – Sorbonne Université. Ses travaux portent sur le code écrit et son histoire des origines à nos jours. Son ouvrage «Écrire le français, toute une histoire» est publié aux éditions Actes Sud. Dans la chronique Ailleurs, nous parlerons du Festival Beyrouth Livres qui aura lieu dans la capitale libanaise, du 22 au 26 octobre 2025. Et c'est Sarra Ghorbal, attachée pour le livre et le débat d'idées et co-commissaire générale du festival Beyrouth livres qui nous parle de l'évènement. Programmation musicale : Le collectif musical Lamomali avec le titre Totem.
VOV1 - Đúng như lo ngại của giới phân tích, ngày 19/10, quân đội Ix-ra-en tiếp tục tiến hành các hoạt động quân sự đáng lo ngại, đó là tấn công vào dải Ga-da và không kích vào quốc gia láng giềng Libăng.
Todo empezó con el descubrimiento de sepulcro del Apóstol Santiago en el primer tercio del siglo IX. Esto impulsó a muchos cristianos a peregrinar hasta Compostela. Para ello era necesaria la construcción de una iglesia que permitiera, por un lado guardar la sagrada tumba del santo, por otro custodiar y honrar sus reliquias y la de sus discípulos Teodoro y Atanasio, y por último acoger una gran cantidad de peregrinos llegados de los reinos peninsulares y del resto de Europa. Sus Artífices pretendían convertir Compostela en un lugar de referencia en lo religioso y en lo artístico, como Roma o Jerusalén. Fueron los comienzos de una historia fascinante, una fabulosa epopeya llevada a cabo durante siglos, por miles de personas unidas por la devoción a la figura del Apóstol Santiago, en un apartado rincón del Finisterre. Le llamaban Compostela: el campo de las estrellas. La Catedral de Santiago es el resultado de numerosos cambios, proyectos, obras, remodelaciones, en fin, una dilatada y apasionante creación arquitectónica y artística desarrollada a lo largo de los siglos y de la que hoy podemos disfrutar. Aunque desde la Edad Media, Jerusalén, Roma y Santiago, han sido los tres grandes centros de peregrinación, la ruta jacobea o Camino de Santiago, es la única que aun se realiza de la misma forma que entonces: a pie y con el zurrón al hombro. Hacía tiempo que la noticia del descubrimiento del sepulcro de Santiago había llegado a Francia. Eran tiempos oscuros y peligrosos. El terror se desató al conocerse que el ejército sarraceno había arrasado Compostela. Almanzor había destruido su Basílica y demás iglesias y monasterios. El obispo Diego Peláez decidió construir una nueva Iglesia que reemplazase a la basílica prerrománica. Sobrevolamos la ciudad de Santiago, desde el aire podemos contemplar la catedral y cerca de ella la iglesia de San Félix de Solovio. Y es en este lugar donde las crónicas cuentan que un ermitaño llamado Pelayo, observó unas luces que brillaban sobre la antigua ciudadela romana. Ante tales noticias, el obispo acude al lugar y entre la maleza, descubre la entrada de un pequeño sepulcro. Sobre el sepulcro se construyó una iglesia para venerar las reliquias del Apóstol. Las obras concluyen en el 830 y el Obispo Teodomiro consagra la primera Iglesia de Santiago. La nueva basílica se consagra en el año 899. En el año 1101, y ya en Santiago, tras ser nombrado obispo por el Papa Pascual II, Diego Gelmírez se aprestó a poner en marcha sus proyectos. El primero debía ser la conclusión de la catedral. Era evidente que si quería conseguir que la Iglesia de Santiago llegara a ser esa gran sede apostólica, debía de estar a la vanguardia del arte. Para ello patrocinó continuos intercambios entre los obradores compostelanos y los más avanzados de la época. El Camino de Santiago se había convertido, definitivamente, en un torrente de intercambio cultural y artístico, entre Galicia y el resto de Europa. Diego Gelmírez había cumplido todos sus objetivos: la construcción de la catedral iba por buen camino y era un referente del arte románico europeo. El 21 de abril de 1211, el arzobispo Pedro Muñiz, en presencia del rey Alfonso IX, consagró la catedral románica de Santiago. La visita de Juan Pablo II y después la de Benedicto XVI en el año santo compostelano de 2010, rodeados de una ferviente multitud de peregrinos venidos de todas partes del mundo, demuestran la magnífica vitalidad que hoy muestra el culto Jacobeo. Pero a pesar de todos los cambios, la obra de Peláez y Gelmírez, de los maestros Bernardo, Esteban, Mateo y tantos otros sigue inalterable y reconocible. En los espacios de sus naves, columnas, tribunas, capillas y pórticos se conserva el espíritu de todos aquellos que contribuyeron a edificarla.
A UNESCO lança hoje três novos volumes d'A História Geral de África, efectuados com recurso a mais de 60 académicos em 28 países diferentes e de forma a aproximar este conhecimento sobre o continente africano dos mais jovens, a organização lança ainda um jogo de vídeo sobre a vida de 10 figuras de destaque em África, incluindo a rainha Nzinga. A UNESCO lança hoje na sua sede, em Paris, os volumes IX, X e XI d'A História Geral de África que começou a ser publicada em 1965, de forma a restabelecer e actualizar a história do continente africano vista e contada pelos africanos. Estes novos volumes vão incidir sobretudo sobre a história revisitada de África, com as mais recentes actualizações sobre este continente como berço da civilização, um outro volume é dedicada às diásporas africanas no Mundo e um último é consagrado aos mais recentes avanços no continente. Para acompanhar a publicação destes novos volumes, a UNESCO lança também um jogo de vídeo que estará disponível para iOS, Google Play ou ainda Xbox sobre o percurso extraordinário de 10 figuras africanas incontornáveis. Lídia Brito, antiga ministra moçambicana e actualmente sub-directora geral da UNESCO para as Ciências Exactas e Naturais falou na importância de serem os africanos a escrever a sua própria história. "Para a preparação destes novos volumes da UNESCO. Adoptou, como o fizemos antes, uma abordagem amplamente consultiva, organizando workshops, reuniões de especialistas e sessões ampliadas do Comité Científico que incluíram outros especialistas do continente e da diáspora. Este processo, a nosso ver, permitiu que investigadores de diferentes formações linguísticas, culturais disciplinares trocassem perspectivas e construíssem uma narrativa partilhada sobre o passado recente de África e das suas diásporas e os seus desafios contemporâneos. Como é sabido, os volumes anteriores concentraram-se principalmente na reconstrução da história africana, que por muito tempo foi negada ou distorcida, ou mesmo, eu diria, se calhar, falsificada. Tratou-se de um compromisso de uma geração inteira determinada a reconstruir a história das sociedades africanas em bases sólidas. Neste novo esforço, nestes três novos volumes, além de actualizar a colecção, eles mapeiam e analisam a história das diásporas africanas em todo o mundo. Estes volumes também expandem a narrativa do continente até ao período contemporâneo, explorando o papel de África na globalização, a vitalidade das suas diásporas e as transformações sociais, políticas e culturais que moldam o seu futuro. Em resumo, eu diria que esta iniciativa reafirma com força o princípio fundamental que os africanos devem ser os principais intérpretes da sua própria história", disse Lidia Brito. De forma a chegar aos mais jovens, a UNESCO lança também nesta sexta-feira um jogo, "African Heroes" ou "Heros Africains", contando o percurso extraordinário de 10 figuras africanas, incluindo a rainha Nzinga, símbolo da resistência em Angola. "É extremamente importante que os jovens africanos estudem a sua história a partir das perspectivas africanas. E, sem dúvida, que isso cria uma autoestima e desenvolve uma identidade africana. E é por isso que nós também decidimos, para além de trabalhar com os ministérios de Educação, com os manuais de como incluir a história geral da África no currículo, nós também decidimos que era importante encontrar os jovens onde eles estão e, portanto, desenvolvemos este este jogo que é que um experiência piloto, sobre heróis africanos. Através dos jogos e de maneira lúdica, os jovens podem conhecer a sua própria história naquilo que pensamos que é uma forma extremamente envolvente, acessível a todos", concluiu Lidia Brito.
Andrea Zabric je slikarka, ki živi med Dunajem, Ljubljano in Krasom. Njeni projekti so konceptualno oblikovani in se medsebojno prepletajo. V najnovejši razstavi Le model v prostorih Zavoda 2^32 v Ljubljani je v sklopu dolgometražnega avtorskega projekta predstavila deveto tuto. Tuta v primorskem narečju označuje delovno obleko v enem kosu – prva tuta je bila narejena po merah umetnice same, deveta tuta pa po merah modela, to je bila Tjaša Stanić Gjorgjievski, ki je tuto na otvoritvenem performansu tudi nosila. Poleg nje je nastopil trobentač Nikola Vuković, ki je logiko postavitve, ta pa razkriva notranjo zgradbo projekta, prevedel v slušno izkušnjo. Umetnica je tuto IX posvetila Thei Černigoj, konstruktivistki, ki za seboj ni pustila veliko del. Andreo Zabric vselej zanimajo ravno tiste predstavnice umetniških gibanj, ki v kanonu niso prepoznane. ''Gre za pogosto zanemarjeno obliko sobivanja in ustvarjanja med zakonci (v tem primeru Avgustom Černigojem v času tržaškega konstruktivizma). Piše se premalo kolabiografij.'' Foto: Sara Rman: Dokumentacija projekta tuta IX, 2025, za ''Le Model'', v produkciji Zavoda 2^32.
Vida em Plenitude (Cap. A Influência dos Espíritos). L.E. qt. 459, Cap. IX, Da Intervenção dos Espíritos no Mundo Corporal: Faculdade que tem os Espíritos de Penetrar os nossos pensamentos: qt. 456, 457, 460, 461, 465, 466. Obras básicas e complementares da Doutrina Espírita. (live no YouTube). Palestrante: Conceição Cavalcante
Long live weird Nintendo! Last week, Nintendo released a new short film created by Nintendo Pictures...not once, not twice, but three times, and Patrick and Mark wonder if there's more than meets the eye to this new Pikmin animation. Plus, Nintendo is hit by a hacking group, Mina the Hollower is delayed, and more.The guys also talk about:Patrick's continued adventures in Hades II.Mark forsaking Dragon Quest III HD-2D in the name of more Mario Galaxy 2.The origins of Kirby and the Forgotten Land + Star-Crossed World.Final Fantasy VII, VIII, and IX getting a physical release on Switch.SUPPORT US ON PATREON: https://www.patreon.com/nintendocartridgesocietyFRIEND US ON SWITCH / SWITCH 2Patrick: SW-1401-2882-4137Mark: SW-8112-0583-0050
Kilka miesięcy temu z fabryki w morawskiej Koprzywnicy wyjechała ostatnia z prawie 160 tysięcy wyprodukowanych tam ciężarówek Tatra 815. Zastąpiły ją dwa kolejne, równie popularne wszędzie tam, gdzie potrzebny jest ciężki, terenowy i prosty w utrzymaniu wóz, modele. A co najciekawsze, od czasów legendarnej Tatry 111, która najpierw Niemcom pomogła Europę zniszczyć a potem zwycięzcom II wojny światowej ją odbudować, pojazdy marki Tatra wciąż bazują na tych samych, sprawdzonych rozwiązaniach - centralnej, rurowej ramie, niezależnym zawieszeniu i chłodzonych powietrzem silnikach.95 odcinek Czechostacji zamyka rozpoczęty we wrześniu tryptyk o Tatrze. Tym razem Karol Machi z wrocławskiego ośrodka Pamięć i Przyszłość opowiada właśnie o koprzywnickich, produkowanych od wojny do dzisiaj, ciężarówkach. Nie omawia oczywiście wszystkich - to wyjątkowo płodna jeśli chodzi o liczbę modeli marka. Ale o zaprojektowanej dla Wehrmachtu 111, jej następcach - modelach 138 i 148 i o właśnie 815, która pracowała od Afryki i Ameryk, po Sachalin, która wiele razy wygrywała rajd Paryż-Dakar i która zagrała w ostatnim Mad Maxie dowiecie się z tej rozmowy całkiem sporo.Swoją część w tej opowieści mają też czescy podróżnicy Jiří Hanzelka i Miroslav Zikmund, którzy tatrami - osobową 87 i ciężarowymi 805. W rozmowie znajdziecie też parę polecajek dotyczących muzeów, w których tatry - i nie tylko, można oglądać. Rozmowa jest kontynuacją poprzednich odcinków o Tatrze, które znajdziecie tutaj:O początkach markiO osobowych samochodach TatryTutaj natomiast możecie posłuchać o regionie morawsko-śląskim, w którym znajduje się Koprzywnica.Poniżej natomiast znajdziecie dwa podcasty o aktualnej, powyborczej sytuacji w Czechach, w których występuję - dla odmiany, jako gość:Po prostu wschód - podcast Piotra Pogorzelskiego w Polskim RadiuGilotyna FM - podcast Wojtka Żubra Bolińskiego***Jeśli podcast Wam się podoba i chcecie pomóc go rozwijać, możecie zostać Patronami lub Patronkami Czechostacji w serwisie Patronite. W tym tygodniu zdecydowali się na to:Adam, Barbara, Grzegorz, Jerzy, Maciej, Michał i PiotrBardzo Wam dziękuję
This week on Nintendo Pow BlockThis week on Nintendo Pow Block, Edward Varnell and Corey Dirrig break down the latest Nintendo news! Assassin's Creed Shadows has been rated by PEGI and may be coming to Nintendo Switch 2 after a retailer listing leaks its Game-Key Card version. Square Enix is finally giving Final Fantasy VII, VIII, and IX physical releases in North America this December. Meanwhile, the Nintendo Switch 2 continues to dominate with record-breaking sales, and Nintendo Pictures debuts its Close to You short films featuring Pikmin!All this and more on Nintendo Pow Block!Follow our Hosts: Edward Varnell, Cofounder of Boss Rush NetworkCorey Dirrig, Founder of Boss Rush Media and the Boss Rush NetworkJoin the Boss Rush Community: Join the Boss Rush Network Community DiscordFollow Boss Rush Network: Follow Boss Rush Network on X/Twitter, Bluesky, Facebook, LinkedIn, Threads, and InstagramSupport Boss Rush Network:Support Boss Rush on Patreon and buy merch on our Store. Subscribe to Boss Rush on YouTube and visit our website at BossRush.net for more great content.Thank you for your Support!Thank you for watching or listening to Nintendo Pow Block, the Nintendo podcast from Boss Rush Network! If you enjoyed the show, be sure to subscribe to the channel, give the video a Like, and hit the notification bell so you never miss an episode. If you're listening on Apple Podcasts, Spotify, or any other podcast app, please leave us a 5-star rating and a review—it really helps! For more great content, visit our website at BossRush.net. Thanks for your continued support of Nintendo Pow Block and our independent endeavor with the Boss Rush Network!
Tenho as chaves da morte e do inferno. Escreve as coisas que tem visto, e as que são, e as que depois hão de acontecer. O mistério das estrelas e dos castiçais de ouro. As estrelas são os anjos, e os castiçais são as regiões. Quanto aos que me rejeitam covardemente, e aos corruptos... a sua parte será no lago que arde com fogo e enxofre; o que é a segunda morte. Veio para o que era o seu, e os seus o rejeitaram. Eis que vem aquele que é mais poderoso do que eu, a quem não sou digno de desamarrar as sandálias. Este é colocado para queda e elevação de muitos, e para sinal que é contraditado. Será grande; e reinará eternamente, e o seu reino não terá fim. Na verdade, se não forem inocentes como crianças, de modo algum entrarão no reino dos céus.Apocalipse 1:18-20; 21:8João 1:11Lucas 3:16-17; 2:34; 1:32-33Mateus 18:3 O mal causado por líderes, governantes corruptos; e o antigo e pobre mensageiro Miqueias, viu a Sentença sobre Samaria e Jerusalém (Mateus 11:20-24/Lucas 10:12-16; 19:41-44). (Mateus 10:28-38/Lucas 12:35-53). Miqueias 4:1-12; 5:2-9,15; 6:2-16; 7:1-14Apocalipse 10:1-3; 18:4-5; 13:16-18; 6:12-17; 20:1-2,12-15; 22:16,14-15 Art. 22. Compete privativamente à União legislar sobre: I – direito civil, comercial, penal, processual, eleitoral, agrário, marítimo, aeronáutico, espacial e do trabalho; II – desapropriação;III – requisições civis e militares, em caso de iminente perigo e em tempo de guerra;IV – águas, energia, informática, telecomunicações e radiodifusão; V – serviço postal; VI – sistema monetário e de medidas, títulos e garantias dos metais; VII – política de crédito, câmbio, seguros e transferência de valores; VIII – comércio exterior e interestadual; IX – diretrizes da política nacional de transportes; X – regime dos portos, navegação lacustre, fluvial, marítima, aérea e aeroespacial; Constituição Federal - Edição STF
ANGELA'S SYMPOSIUM 📖 Academic Study on Witchcraft, Paganism, esotericism, magick and the Occult
Across three millennia, the goddess Astarte was recast as the demon Astaroth: a transformation that reveals more about humanity's fear of the sacred feminine than any real change in divinity. This episode traces that metamorphosis from ancient Mesopotamian goddess to grimoire demon and modern occult archetype. Drawing on sources from biblical polemics and Renaissance demonology, as well as feminist and queer reimaginings, this exploration examines how Astaroth embodies the persistence of forbidden knowledge, gender fluidity, and spiritual defiance. Was Astaroth truly a fallen angel or the suppressed face of divine wisdom, buried under centuries of theological sabotage? CONNECT & SUPPORT
Summary of the Message: “Kingdom, Power, Glory: Quietness + Confidence = Strength” by Pastor Bryan Hudson, D.Min. I. INTRODUCTION: THE DISCIPLE'S REQUEST AND THE KINGDOM CONTEXT A. The Request: “Lord, Teach Us to Pray” (Luke 11:1; Matthew 6:9–13) Jesus models prayer for His disciples—not the Lord's prayer, but our prayer. The prayer closes with a reminder of divine ownership and sovereignty: “For Yours is the Kingdom, and the Power, and the Glory forever.” B. Meaning of the Three Realms of God Kingdom – God's rule and authority. Power – God's ability to accomplish His will. Glory – God's majesty and divine presence. These belong to God alone; not to governments, politicians, or human systems. Believers operate in a higher kingdom, with higher power, for the glory of God. II. THE KINGDOM IS LIGHT IN A DARK WORLD A. The Bright Light of God's Kingdom (Matthew 5:14) Jesus said, “You are the light of the world; a city on a hill cannot be hidden.” Christ has transferred His light to His followers. Application: You are already visible—so shine. Others are already watching, so be the light. “You may as well shine!” III. THE KINGDOM IS TRANSFORMATIVE A. The Call of the Disciples (Matthew 4:18–20) Jesus said, “Follow Me, and I will make you fishers of men.” Transformation begins when we follow; God makes us. The Kingdom changes identity and purpose. B. Cooperation with God's Transforming Power Transformation requires yielding, not striving. God's kingdom forms new purpose, power, and personhood. IV. THE KINGDOM IS FULL OF STRENGTH (Isaiah 30:15–16) “In returning and rest you shall be saved; In quietness and confidence shall be your strength; But you would not…” A. The Prophetic Context Judah sought political alliances (Egypt) instead of trusting God. God rebuked them: “You take counsel, but not of Me.” The warning: reliance on worldly systems leads to weakness and dependence. B. Worldly Systems vs. God's Kingdom Earthly systems concentrate power and wealth among a few. God's kingdom strengthens, uplifts, and liberates people. True strength is found only in God's rule. V. THE FALSE STRENGTH OF SPEED AND STRIVING A. The Futility of Running Faster “We will flee on swift horses…” — but “those who pursue you shall be swift.” You cannot outrun anxiety, distraction, or fear. The faster you run, the faster your troubles seem to chase you. Principle: The answer is not speed but stillness. B. Modern Application People try to fix weakness by posturing strength—pretending to be powerful. Strength doesn't come from acting strong but from quietness of heart and confidence in God. VI. TRUE STRENGTH ILLUSTRATED: HARRIET TUBMAN A. Example of Spiritual Strength Physically small (about 5 feet tall), formerly enslaved, but mighty in faith. Escaped 90 miles to freedom and returned to rescue ~70 others. Served as a scout and spy during the Civil War and later as an activist. B. The Source of Her Strength Quote: “I prayed to God to make me strong and able to fight.” Her strength came from God, not size or status. True strength is moral, spiritual, and rooted in trust and courage. VII. RETURNING, RESTING, AND KNOWING GOD A. Returning and Rest (Isaiah 30:15) Returning = repentance — turning back to God. Rest = tranquility and settledness. Deliverance comes through surrender, not striving. Rest is not inactivity—it is trusting the power of another (God). B. Quietness and Confidence Quietness: Calm heart; stillness of spirit. Confidence: Assurance in God's character and promises. “Be still and know that I am God” (Psalm 46:10). You know only after you be still. Stillness allows God's presence to fill the heart. C. Results of Quiet Confidence “The work of righteousness will be peace” (Isaiah 32:17). When God is with you, you can move without fear. If you are still fearful—sit back down until peace returns. VIII. THE HUMAN TENDENCY TO MOVE FASTER A. God Says: “Rest.” Humanity Says: “No.” Israel said, “We will flee on swift horses.” Principle: The human reflex is to move faster rather than trust deeper. Lesson: You need stillness, not speed. B. Trust in God, Not in Systems “Some trust in chariots, and some in horses, but we will remember the name of the Lord our God.” (Psalm 20:7) Wealth, systems, and networks can change—but God remains faithful. Even abundance (money, success) is no substitute for trust in the Lord. IX. THE POWER OF STILLNESS A. Stillness Is Productive, Not Passive God's kingdom is productive—just not busy. Stillness reorders priorities and aligns you with God's presence. It helps you reframe life's situations through faith: “It's bad, but God's got it.” “It's chaotic, but God's got me.” B. Illustration: Captain “Sully” Sullenberger During the “Miracle on the Hudson,” he acted calmly under pressure. His stillness allowed his training—and God's grace—to work. Lesson: You can't perform CPR, pilot a plane, or save a life while frantic. Stillness lets knowledge, faith, and grace operate effectively. X. THE INVITATION TO REST IN CHRIST (Matthew 11:28) “Come to Me, all you who labor and are heavy laden, and I will give you rest.” A. God's Offer vs. Humanity's Resistance Many hear this call but refuse it—choosing “swift horses” instead. Jesus invites us to stop striving and receive His rest. XI. APPLICATION AND RESPONSE 1. Return to God Daily Repent, realign, and rest—make it a daily rhythm. Don't wait for crisis to return; stay aligned continuously. 2. Seek Strength Through Quiet Time Prayer and meditation on God's Word. Meditate—turn truth over and over until it shapes your heart. 3. Value Stillness with God Over Speed Without Him Resist the culture of hurry. Strength grows in quiet confidence, not constant motion. 4. Trust That When You Stop Striving, God Starts Moving Let surrender activate divine strength. Faith rests, and rest becomes power. XII. CONCLUSION AND PRAYER Summary Statement: “Quietness + Confidence = Strength.” God's kingdom is not built on noise, speed, or display—but on returning, resting, and trusting. Closing Prayer Highlights: Thank God for His kingdom, power, and glory. Ask for grace to practice stillness, repentance, and confidence. Celebrate examples of spiritual strength (like Harriet Tubman). Reaffirm trust in God's rule: “Yours is the Kingdom, the Power, and the Glory, forever.”
LinksQuotes to get right. #runx · GitHub“People aren't supposed to look back.”Reconcilable Differences #270: We Inflated Our Pants - RelayValley Girl (1983 film) - WikipediaYork Steak House - WikipediaThe Awards for Advertising American Ads - YouTubeMerlin's Happy Place - YouTubeEdward Elgar - Enigma Variations, Op.36: IX. (Nimrod) - YouTubeDon Henley - The Boys Of Summer - YouTubeThe Ataris - The Boys of Summer - YouTubeDuck Soup (1933 film) - WikipediaAFI Movie Club: DUCK SOUP | American Film InstituteSqueeze - Is That Love? (Official Music Video) - YouTubeDeadspin | The GookieRufus T Fireflys introduction - YouTubeThe Lemonade Vendor - YouTube"This Country's Going to War" - YouTubePre-Code Hollywood - WikipediaHays Code - WikipediaAnti-Catholicism in the United States - WikipediaThe Very Weird Rules of Golden Age Hollywood: The Hays Code and the effect it still has today! - YouTubePolitics and the Star Persona of Katharine Hepburn - YouTubeGroucho Marx Dick Cavett 1969 - YouTubeSqueeze - Is That Love? (Official Music Video) - YouTube
Urmăriți un frumos material ce ne prezintă un poem de mare adâncime, scris de un poet anglo-saxon din secolul IX, Cynewolf, poem ce are ca temă Înălțarea Domnului.Vizionare plăcută!Pentru Pomelnice și Donații accesați: https://www.chilieathonita.ro/pomelnice-si-donatii/Pentru mai multe articole (texte, traduceri, podcasturi) vedeți https://www.chilieathonita.ro/
This week we're discussing every album by ...And You Will Know Us by the Trail of Dead. Led by core members Conrad Keely and Jason Reece (who both trade off between drums, guitars and vocals), Trail of Dead is one of the most fun and ambitious post-hardcore bands around. And although they have a trademark sound, they've continued to evolve and expand their sound in countless ways. Dig it. Intro 00:00 (The Episodes Are Back Up Now) 13:31 Band Overview 17:46 ...And You Will Know Us by the Trail of Dead 25:16 Madonna 38:21 Source Tags & Codes 49:24 Worlds Apart 1:03:47 So Divided 1:18:00 The Century of Self 1:29:40 Tao of the Dead 1:41:16 Lost Songs 1:49:23 IX 2:00:04 X: The Godless Void and Other Stories 2:09:04 XI: Bleed Here Now 2:20:26 Outro 2:34:50 ---------------------------------------------------------------------------------------------------------- Patreon https://www.patreon.com/everyalbumever Merch https://pandermonkey.creator-spring.com/ Mike's EP: Pander Monkey on Bandcamp, Spotify, Apple, Mike on Instagram @pandermonkey Alex on Bluesky @octatron3030 Tom on Instagram @tomosmansounds History Tom's stuff: Music on Spotify, Apple Podcast on Spotify, YouTube Substack Website ---------------------------------------------------------------------------------------------------------- Mike's Picks: ...And You Will Know Us by the Trail of Dead (1998) -- Best Album, Personal Favorite So Divided (2006) -- Worst Album X: The Godless Void and Other Stories (2020) -- Least Favorite Alex's Picks: Worlds Apart (2005) -- Best Album, Personal Favorite IX (2014) -- Worst Album, Least Favorite
En la segunda conferencia del ciclo “Una historia del dinero y la moneda en el mundo antiguo”, Manel Ollé, profesor titular de Historia y cultura de la China moderna y contemporánea de la Universidad Pompeu Fabra, explica la evolución de la moneda en China, así como su producción, su circulación y su función dentro del circuito económico y fiscal. Las monedas se realizaban a partir de metales fundidos, y, posteriormente, a inicios del IX d. C., se inventó en China el papel moneda.Más información de este acto
Budzący wiele emocji w Czechach i poza nimi miliarder Andrej Babiš wygrał właśnie zdecydowanie wybory parlamentarna w swoim kraju. I wszystko wskazuje na to, że po czteroletniej przerwie wróci do fotela premiera. Odcinek ten jednak nie dotyczy bieżącej czeskiej polityki.Razem z Wojciechem Stobbą, korespondentem Polskiego Radia w Pradze przedstawiamy sylwetkę pochodzącego ze Słowacji lidera ruchu ANO - akcji niezadowolonych obywateli, bądź też - tłumacząc sam skrót - po prostu TAK.Opowiadamy o spędzonym w Szwajcarii dziecińskie syna komunistycznych dygnitarzy, o tym co wiadomo o jego możliwej współpracy z bezpieką i o tym, jak z przedstawiciela handlu zagranicznego CSSR w Maroku po przemianach ustrojowych przedzierzgnął się w czeskiego biznesmena.Z odcinka nie dowiecie się, tak jak nikt się dotychczas nie dowiedział, skąd dokładnie pochodził milion dolarów, który pozwolił Andrejowi Babišowi położyć fundamenty pod największy obecnie w Czechach koncern rolno-spożywczy - konglomerat ponad 200 firm, zatrudniających kilkadziesiąt tysięcy ludzi i produkujący wszystko co z rolnictwem i żywnością związane: od nawozów i środków ochrony roślin, po biopaliwa i kurczaki i chleb tostowy.Jest oczywiście też o politycznej karierze oligarchy, o jego społecznym słuchu i wyjątkowej umiejętności, która pozwala inteligentnemu, wychowanemu na zachodzie poliglocie z powodzeniem zjednywać sobie ludzi w trudnej sytuacji ekonomicznej.Odcinek w bardzo niewielkim stopniu odnosi się do bieżącej sytuacji politycznej w Czechach. Ale jeśli kogoś interesuje, dlaczego dotychczas rządząca koalicja przegrała wybory z kretesem i co może oznaczać wybór Andreja Babiša, może sięgnąć po niedawne rozmowy o startujących w czeskich wyborach komitetach:O partiach systemowychO partiach antysystemowychO polskiej i czeskiej polityce ostatnich 30 latJeśli podcast Wam się podoba i chcecie pomóc go rozwijać, możecie zostać Patronami lub Patronkami Czechostacji w serwisie Patronite. W tym tygodniu zdecydowali się na to:Beata, Gosia, Iza i SzymonBardzo Wam dziękuję
In this episode, Jeff is joined by his writing partner, Dialogue Doctor Coach JP Rindfleisch the IX. Jeff and JP talk about the book The Hidden Tools of Comedy by Steve Kaplan. They discuss Kaplan's theory of comedy, talk about the comedic equation, and then discuss the 8 tools of comedy. Find Steve Kaplan's book here: https://www.amazon.com/Hidden-Tools-Comedy-Serious-Business/dp/1615931406 Check out JP's work here: https://shop.jprindfleischix.com/ Check out Jeff and JP's Kickstarter here: https://www.kickstarter.com/projects/jprindfleischix/nrds-queer-paranormal-comedy-seasons-1and2-special-editions For more on the craft of writing, go to https://dialoguedoctor.com/
Esta semana, falamos do anel de Iffland e da morte de Sigurd Eysteinsson, Jarl das ilhas Orkney, no séc. IX.Sugestões da semana1. António Araújo - O Essencial sobre Sidónio Pais. INCM, 2025. Disponível online: https://imprensanacional.pt/?w3n_livros_pdf=o-essencial-sobre-sidonio-pais2. Amélia Polónia (coord) - Construtoras de Impérios. Vozes de Mulheres na Expansão Portuguesa. Temas e Debates, 2025.----Obrigado aos patronos do podcast:André Silva, Bruno Ricardo Neves Figueira, Cláudio Batista, Gustavo Fonseca, Isabel Yglesias de Oliveira, Joana Figueira, Manuel Prates, Miguel Vidal, NBisme, Oliver Doerfler;Alessandro Averchi, Alexandre Carvalho, Andre Oliveira, Carla Pinelas, Carlos Castro, Cláudia Conceição, Daniel Murta, David Fernandes, Domingos Ferreira, É Manel, Francisco, Hugo Picciochi, João Cancela, João Carreiro, João Pedro Tuna Moura Guedes, Jorge Filipe, Jose Carlos Bicudo, Luís André Agostinho, Patrícia Gomes, Pedro Almada, Pedro Alves, Pedro Ferreira, Rui Roque, Tiago Pereira, Vera Costa; Adriana Vazão, Ana Gonçalves, Ana Sofia Agostinho, André Abrantes, Andre de Oliveira, André Silva, António Farelo, António Silva , Bruno Luis, Carlos Afonso, Carlos Ribeiro, Carlos Ribeiro, Catarina Ferreira, Civiforum, Lda., Diogo Camoes, Diogo Freitas, Eugenia Capela, Fábio Videira Santos, Francisco Fernandes, Gn, Gonçalo Pedro, Hugo Palma, Hugo Vieira, Igor Silva, João Barbosa, João Canto, João Carlos Braga Simões, João Diamantino, João Félix, João Ferreira, Joao Godinho, João Pedro Mourão, Joel José Ginga, Johnniedee, José Beleza, José Santos, Luis Colaço, Miguel Brito, Miguel Gama, Miguel Gonçalves Tomé, Miguel Oliveira, Miguel Salgado, Nuno Carvalho, Nuno Esteves, Nuno Silva, Parte Cóccix, Paulo Silva, Pedro, Pedro Cardoso, Pedro Oliveira, Pedro Simões, Ricardo Pinho, Ricardo Santos, Rui Curado Silva, Rui Rodrigues, Simão, Simão Ribeiro, Sofia Silva, Thomas Ferreira, Tiago Matias, Tiago Sequeira, Tomás Matos Pires, Vitor Couto.-----Ouve e gosta do podcast?Se quiser apoiar o Falando de História, contribuindo para a sua manutenção, pode fazê-lo via Patreon: https://patreon.com/falandodehistoria-----Música: "Hidden Agenda” de Kevin MacLeod (incompetech.com); Licensed under Creative Commons: By Attribution 4.0 License, http://creativecommons.org/licenses/by/4.0Edição de Marco António.
Kiinalaiset automerkit jatkavat maihinnousuaan Suomeen, ja tällä kertaa tarjolla on GAC-konsernin sähköauto Aion jopa kahdella mallillaan. Perinteisempien voimalinjojen ystäville Arttu Toivosen testissä Toyota Proace Cityn uusin versio, jonka kulutuslukemat lyövät ällikällä. Alustavaa tuntumaa otetaan myös BMW:n iX:n tuoreimpaan toteutukseen. Toivosen kanssa studiossa tuttuun tapaan Henri Posa.
Hey there folks, this week... we live through hell with all our friends. Next week, we're onto the END of the series, finishing up part IX. Beyond that, please be sure to follow us or subscribe on your podcatcher of choice, and leave a review on iTunes, Stitcher, or wherever. It goes a long way to helping the podcast grow. You can also check out our Patreon at Patreon.com/Wordsandwhiskey Check it out! Another way you could help us out? Refer us to your friends. We love a good referral, don't we folks? Send us ANY questions to our twitter account, Instagram, or to our email. Link: https://wordsandwhiskey.show/episode/274-the-wisdom-of-crowds-part-viii
The boys finish off the story in Final Fantasy X by defeating Yu Yevon and watching how the ending scene unfolds! After, they give their ratings on various categories to put the final nail in X's coffin. It has been a very long journey and the future looks bright as Final Fantasy XII: The Zodiac Age approaches!If you're searching for the beginning of the Final Fantasy X or IX series, check the quick info below!Start of the Final Fantasy X series is episode 43Start of the Final Fantasy IX series is episodes 6
durée : 00:10:46 - Le Fil de l'histoire - par : Stéphanie Duncan - La croisade des Albigeois s'est achevée en 1229 avec beaucoup de sang versé, mais sans que l'hérésie ait pu être éliminée du Languedoc. Par la voix du nouveau pape Grégoire IX, l'Église qui n'entend rien lâcher, met en place une nouvelle stratégie qui va se révéler payante : l'Inquisition. - invités : Arnaud Fossier - Arnaud Fossier : Historien français - réalisé par : Claire DESTACAMP Vous aimez ce podcast ? Pour écouter tous les autres épisodes sans limite, rendez-vous sur Radio France.
Questions & Answers IX - Rev. 3:14-17
Entre los siglos IX y X, numerosas ciudades mayas sufrieron una crisis repentina y acabaron siendo abandonadas. Entre las causas del llamado colapso maya se cuentan la sobreexplotación de los recursos y la espiral de guerras y conflictos intestinos.
Send us a textIn this episode, we cover the last few years of John Vatatzes' reign, and the crazy events that surrounded them. The Seventh Crusade was kicked off by King Louis the IX, and just like the 5th crusade, they attacked the city of Damietta, and then overextended their armies and ultimately lost everything to the Ayyubids, but we also cover the rise of the Mamluks, and the final battle in the life of Frederick II. The rise of the Empire of Nicaea is about to take a turn as its allies crumble, and the Laskarid Dynasty enters its final years.The History of Modern Greece Podcast covers the events from Ancient Greece, the Roman Empire, and the fall of Constantinople in 1453, to the years under the Ottoman Empire, and 1821 when the Greeks fought for independence... all the way to the modern-day.Website: www.moderngreecepodcast.comSOCIAL MEDIA: Go here to chat with us. https://www.instagram.com/historyofmodern%20greece/https://www.facebook.com/profile.php?id=61578023316172Music by Mark Jungerman: www.marcjungermann.comCheck out our 2nd Podcast: www.antecedors.com
Do dnešnej epizódy podcastu Flešbeky si moderátor Ivan pozval Jána „Honzíka“ Goroľa, herca a lídra kapely GPS, ktorý je aktívne zapojený do gréckokatolíckej rómskej misie. Ján opisuje, ako sa z vyrastania v takmer neveriacej rodine v rómskej osade dostal k živej viere v Ježiša, a spomína moment, keď ako malý chlapec takmer prišiel o život. Hovorí aj o svojej ceste k profesionálnemu herectvu a o hudobných začiatkoch kapely GPS, v ktorej pôsobí ako spevák. V podcaste sa dotýka aj tém gréckokatolíckej misie, spomína zážitok zo spevu pred pápežom Františkom na Luníku XI. a rozpráva o svojom hudobnom pôsobení na Godzone tour.0:00 Úvod a predstavenie2:06 Miska otázok2:37 Čo by si odkázal svojmu mladšiemu ja?3:13 Aký film alebo seriál by najvernejšie opísal tvoj minulý týždeň?3:55 Aká maličkosť ti naposledy spravila radosť?4:32 Aké je tvoje najobľúbenejšie jedlo?5:56 Súťaž o knihu Prežívať Otcovo objatie: https://www.godzoneshop.sk/produkt/prezivat-otcovo-objatie-nove-vydanie-jack-frost/6:28 Úryvok z knihy Prežívať Otcovo objatie8:30 Honzíkov príbeh obrátenia17:47 10 minút mŕtvy?! 22:53 Divadelná kariéra30:12 Honzíkova cesta k hudbe a vznik kapely GPS 34:49 Čím sú výnimočné rómske chvály?37:40 Ako prebieha evanjelizácia v rómskych osadách?41:19 Ako funguje Gréckokatolícka rómska misia?45:36 Spev pred pápežom Františkom na Luníku IX. 48:54 Prvá skúsenosť s Godzone tour52:16 Služba na turné58:11 Poďakovanie a rozlúčenie
The Apostles IX - Philip - Acts 22:16
Head to https://squarespace.com/jonsolo to save 10% off your first purchase of a website or domain using code JONSOLO! Thanks to Squarespace for sponsoring the show!
¡Juega y gana gratis con Descifrando a León!Entérate antes de todos de lo que pasa dentro del Vaticano en www.descifrandoaleon.com, ¡Regístrate gratis! Sigue a Inés San Martín a Javier Martínez Brocal y a José Manuel De Urquidi.Segmentos de hoy:La Voz del Papa Las 5 Noticias de la Semana por Javier, más el bonus Análisis de la Semana por InésEl Archivo de los Leones (León IX) por Javier¿Qué tanto saben los expertos de los santos?La Comunidad de León (¡Juega aquí!)La Recomendación Online de la Semana Homilía Remix ++++++++++++++++++++++++++++Este episodio es posible gracias a Amen Apps, la plataforma en la que puedes obtener consejos y ayuda espiritual de sacerdotes y religiosos 24x7.Descarga el app gratis en:AndroidiPhonePágina AmenUn podcast de Juan Diego Network
Mark and Alex are back with their second-to-last episode in Final Fantasy X! With all of the side content and story just about finished, the boys make their way back into Sin, past the point of no return. The party finally comes face to face with Jecht and everyone knows what must be done...If you're searching for the beginning of the Final Fantasy X or IX series, check the quick info below!Start of the Final Fantasy X series is episode 43Start of the Final Fantasy IX series is episodes 6
hour one: "sweet georgia brown" (live excerpt of private jam from joe brazil's basement in detroit on sep 25, 1958) john coltrane "the mallard variations - cut and dissolve" david gerard "the mallard variations - variation VII" david gerard "an irrational root - r13 - the triangled" church of the annihilation "kontrast" contrastz "its all a bit of a blur" tim holehouse "stupid" (part 2 of 5) bogdan raczynski "fuerza 03" frente abierto "the mallard variations - variation IX" david gerard hour two: "the mallard variations - variation III" david gerard "stables" dave gerard and the watchmen "klee doll" (excerpt) victoria shen "where" torpedo "certified guitar pedal" (prelude) david gerard "the mallard variations - echosphere" david gerard "love" (excerpt) latex "I did not mean to turn you on" (dub you on - candy bomber version) re-201 ft. peter heppner & mika bajinsky "the mallard variations - cinematic counterpoint" david gerard hour three: "the mallard variations - variation V" david gerard "days of rain" it's ok! "abstract deductions" immr "prelude - topographic" david gerard "the temporal nature of things" david gerard "the red trickle" eugene chadbourne "random canyon" (live in detroit 1965) the holy modal rounders "delta jig d'agadir" muskeg mudsuck "we'll all go to heaven when the devil goes blind" up around the sun "untraveled" david gerard & keith richie
Dr. Pedro Barata and Dr. Rana McKay discuss the integration of innovative advances in molecular imaging and therapeutics to personalize treatment for patients with renal cell and urothelial carcinomas. TRANSCRIPT Dr. Pedro Barata: Hello, I'm Dr. Pedro Barata, your guest host of By the Book, a podcast series featuring insightful conversations between authors and editors of the ASCO Educational Book. I'm a medical oncologist at University Hospitals Seidman Cancer Center and an associate professor of medicine at Case Western Reserve University in Cleveland, Ohio. I'm also an associate editor of the ASCO Educational Book. Now, we all know the field of genitourinary cancers (GU) is evolving quite rapidly, and we have new innovations in molecular imaging as well as targeted therapeutics. Today's episode will be exploring novel approaches that are transforming the management of renal cell and urothelial carcinomas and also their potential to offer a more personalized treatment to patients. For that, joining for today's discussion is Dr. Rana McKay, a GU medical oncologist and professor at University of California San Diego. Dr. McKay will discuss her recently published article titled, “Emerging Paradigms in Genitourinary Cancers: Integrating Molecular Imaging, Hypoxia-Inducible Factor-Targeted Therapies, and Antibody-Drug Conjugates in Renal Cell and Urothelial Carcinomas.” Our full disclosures are available in the transcript of this episode. And with that, Rana McKay, great to have you on the podcast today. Dr. Rana McKay: Oh, thank you so much, Dr. Barata. It's really wonderful to be here with you. So, thanks for hosting. Dr. Pedro Barata: No, thanks for taking the time, and I'm looking forward to this conversation. And by the way, let me start by saying congrats on a great article in the Educational Book. Really super helpful paper. I'm recommending it to a lot of the residents and fellows at my own institution. I would like to first ask you to kind of give our listeners some context of how novel approaches in the molecular imaging as well as targeted therapeutics are actually changing the way we're managing patients with GU, but specifically with renal cell carcinoma and urothelial carcinoma. So, what are the areas you would call out as like being big areas for innovation in this context, and why are they important? Dr. Rana McKay: Very good question. And I think this is really what this article highlights. It highlights where are we going from an imaging diagnostics standpoint? Where are we going from a therapeutic standpoint? And I think if we have to step back, from the standpoint of diagnostics, we've seen PET imaging really transform diagnostics in prostate cancer with the advent of PSMA PET imaging, and now PSMA PET imaging is used as a biomarker for selection for theranostics therapy. And so, we're starting to see that enter into the RCC landscape, enter into the urothelial cancer landscape to a lesser extent. And I think it's going to potentially be transformative as these tools get more refined. I think when we think about therapeutics, what's been transformative most recently in the renal cell carcinoma landscape has been the advent of HIF2α inhibition to improve outcomes for patients. And we have seen the approval of belzutifan most recently that has reshaped the landscape. And now there's other HIF2α inhibitors that are being developed that are going to be further important as they get refined. And lastly, I think when we think about urothelial carcinoma, the greatest transformation to treatment in that context has been the displacement of cisplatin and platinum-based chemotherapy as a frontline standard with the combination of enfortumab vedotin plus pembrolizumab. And we've seen antibody-drug conjugates really reshape treatment and tremendously improve outcomes for patients. So, I think those are the three key areas of interest. Dr. Pedro Barata: So with that, let's focus first on the imaging and then we'll get to the therapeutic area. So, we know there's been a paradigm shift, really, when prostate-specific targets emerged as tracers for PET scanning. And so, we now commonly use prostate-specific membrane antigen, or PSMA-based PET scanning, and really transform how we manage prostate cancer. Now, it appears that we're kind of seeing a similar wave in renal cell carcinoma with the new radiotracer against the target carbonic anhydrase IX. What can you tell us about this? And is this going to be available to us anytime soon? And how do you think that might potentially change the way we're managing patients with RCC today? Dr. Rana McKay: First, I'll step back and say that in the context of PSMA PET imaging, we have actually been able to better understand RCC as well. So, we know that PSMA is expressed in the neovasculature of tumors, and it can actually be used to detect renal cell carcinoma tumors. It has a detection rate of about 84% when used for detection. And so, you know, I don't think it's just restricted to carbonic anhydrase IX, but we will talk about that. So, PSMA expressed in the neovasculature has a detection rate of around 84%, particularly if we're looking at clear cell RCC. CAlX is overexpressed in clear cell RCC, and it's actually used in diagnosing renal cell carcinoma when we think of CAlX IHC for diagnosing clear cell RCC. And now there are CAlX PET tracers. The first foray was with the ZIRCON study that was actually an interestingly designed study because it was designed to detect the likelihood of PET imaging to identify clear cell RCC. So, it was actually used in the early diagnostics setting when somebody presents with a renal mass to discriminate that renal mass from a clear cell versus a non-clear cell, and it was a positive study. But when I think about the potential application for these agents, you know, I think about the entire landscape of renal cell carcinoma. This is a disease that we do treat with metastasis-directed therapy. We have certainly seen patients who've undergone metastasectomy have long, durable remissions from such an approach. And I think if we can detect very early onset oligometastatic disease where a metastasis-directed therapy or SABR could be introduced - obviously tested in a trial to demonstrate its efficacy - I think it could potentially be transformative. Dr. Pedro Barata: Wonderful. It's a great summary, and I should highlight you are involved in some of those ongoing studies testing the performance of this specific PET scanning for RCC against conventional imaging, right? And to remind the listeners, thus far, for the most part, we don't really do FDG-PET for RCC. There are some specific cases we do, but in general, they're not a standard scanning. But maybe that will change in the future. Maybe RCC will have their own PSMA-PET. And to your point, there's also emerging data about the role of PSMA-PET scanning in RCC as well, as you very elegantly summarized. Wonderful. So, let me shift gears a little bit because you did, in your introduction, you did highlight a novel MOA that we have in renal cell carcinoma, approved for use, initially for VHL disease, and after that for sporadic clear cell renal cell carcinoma. We're talking about hypoxia-inducible factor 2-alpha inhibitors, or HIF2α inhibitors, such as belzutifan. But there's also others coming up. So, as a way to kind of summarize that, what can you tell us about this breakthrough in terms of therapeutic class, this MOA that got to our toolbox of options for patients with advanced RCC? Tell us a little bit what is being utilized currently in the management of advanced RCC. And where do you see the future going, as far as, is it moving early on? Is it getting monotherapy versus combinations? Maybe other therapies? What are your thoughts about that? What can you tell us about it? Dr. Rana McKay: Belzutifan is a first-in-class HIF2α inhibitor that really established clinical validation for HIF2α as a therapeutic target. When we think about the activity of this agent, the pivotal LITESPARK-005 trial really led to the approval of belzutifan in patients who were really heavily pretreated. It was patients who had received prior IO therapy, patients who had received prior VEGF-targeted therapy. And in the context of this study, we saw a median PFS of 5.6 months, and there did seem to be a tail on the curve when you looked at the 12-month PFS rate with belzutifan. It was 33.7% compared to 17.6% with everolimus. And then when we look at the response rate, it was higher with belzutifan on the order of 22-23%, and very low with everolimus, as we've previously seen. I think one of the Achilles heels of this regimen is the primary PD rate, which was 34% when used in later line. There are multiple studies that are testing belzutifan in combination across the treatment landscape. So, we have LITESPARK-011, which is looking at the combination of belzutifan plus lenvatinib in the second-line setting. We've got the MK-012 [LITESPARK-012] study, which is looking at belzutifan in various combinations in the frontline setting. So there is a combination with IO plus belzutifan. And so this is also being looked at in that context. And then we also have the LITESPARK-022 study, which is looking at pembrolizumab with belzutifan in the adjuvant setting. So there's a series of studies that will be exploring belzutifan really across the treatment landscape. Many of these studies in combination. Additionally, there are other HIF2α inhibitors that are being developed. We have casdatifan, which is another very potent HIF2α inhibitor. You know, I think pharmacologically, these are different agents. There's a different half-life, different dosing. What is going to be the recommended phase 3 dose for both agents, the EPO suppression levels, the degree of EPO suppression, and sustainability of EPO suppression is very different. So, I think we've seen data from casdatifan from the ARC-20 trial from monotherapy with a respectable response rate, over 30%, primary PD rate hovering just around 10%. And then we've also seen data of the combination of casdatifan with cabozantinib as well that were recently presented this year. And that agent is also being tested across the spectrum of RCC. It's being looked at in combination with cabozantinib in the PEAK-1 study, and actually just at the KCRS (Kidney Cancer Research Summit), we saw the unveiling of the eVOLVE-RCC trial, which is going to be looking at a volrustomig, which is a PD-1/CTLA-4 inhibitor plus casdatifan compared to nivo-ipi in the frontline setting. So, we're going to see some competition in this space of the HIF2α inhibitors. I think when we think of mechanism of action in that these are very potent, not a lot of off-target activity, and they target a driver mutation in the disease. And that driver mutation happens very early in the pathogenesis. These are going to be positioned much earlier in the treatment landscape. Dr. Pedro Barata: All these studies, as you're saying, look really promising. And when we talk about them, you mentioned a lot of combinations. And to me, when I think of these agents, it makes a lot of sense to combine because there's not a lot of overlapping toxicities, if you will. But perhaps for some of our listeners, who have not used HIF2α inhibitors in practice yet, and they might be thinking about that, what can you tell us about the safety profile? How do you present it to your patients, and how do you handle things like hypoxia or anemia? How do you walk through the safety profile and tolerability profile of those agents like belzutifan? Dr. Rana McKay: I think these drugs are very different than your traditional TKIs, and they don't cause the classic symptoms that are associated with traditional TKIs that many of us are very familiar with like the rash, hand-foot syndrome, hypertension, diarrhea. And honestly, these are very nuanced symptoms that patients really struggle with the chronicity of being on a chronic daily TKI. The three key side effects that I warn patients about with HIF2α inhibitors are: (1) fatigue; (2) anemia; and (3) hypoxia and dysregulation in the ability to sense oxygen levels. And so, many of these side effects - actually, all of them - are very dose-dependent. They can be very well-managed. So, we can start off with the anemia. I think it's critically important before you even start somebody on belzutifan that you are optimizing their hemoglobin and bone marrow function. Make sure they don't have an underlying iron deficiency anemia. Make sure they don't have B12 or folate deficiency. Check for these parameters. Many patients who have kidney cancer may have some hematuria, other things where there could be some low-level blood loss. So, make sure that those are resolved or you're at least addressing them and supplementing people appropriately. I monitor anemia very closely every 3 to 4 weeks, at least, when people start on these medications. And I do initiate EPO, erythropoietin, should the anemia start to worsen. And I typically use a threshold of around 10g/dL for implementing utilization of an EPO agent, and that's been done very safely in the context of the early studies and phase 3 studies as well. Now, with regards to the hypoxia, I think it's also important to make sure that you're selecting the appropriate individual for this treatment. People who have underlying COPD, or even those individuals who have just a very high burden of disease in their lung, lymphangitic spread, pleural effusions, maybe they're already on oxygen - that's not an ideal candidate for belzutifan. Something that very easily can be done in the clinic before you think about initiating somebody on this treatment, and has certainly been integrated into some of the trials, is just a 6-minute walk test. You know, have the patient walk around the clinic with one of the MAs, one of the nurses, put the O2 sat on [measuring oxygen saturation], make sure they're doing okay. But these side effects, like I said, are very dose-dependent. Typically, if a patient requires, if the symptoms are severe, the therapy can be discontinued and dose reduced. The standing dose is 120 mg daily, and there's two dose reductions to 80 mg and 40 mg should somebody warrant that dose modification. Dr. Pedro Barata: This is relatively new, right? Like, it was not that we're used to checking oxygen levels, right? In general, we're treating these patients, so I certainly think there's a learning curve there, and some of the points that you highlight are truly critical. And I do share many of those as well in our practice. Since I have you, I want to make sure we touch base on antibody-drug conjugates as well. It's also been a hot area, a lot of developments there. When I think of urothelial carcinoma and renal cell carcinoma, I see it a little bit different. I think perhaps in urothelial carcinoma, antibody-drug conjugates, or ADCs, are somewhat established already. You already mentioned enfortumab vedotin. I might ask you to expand a little bit on that. And then in renal cell carcinoma, we have some ADCs as well that you include in your chapter, and that I would like you to tell us what's coming from that perspective. So, tell us a little bit about how do you see ADCs in general for GU tumors, particularly UC and RCC? Tell us a little bit about the complexity or perhaps the challenges you still see. At the same time, tell us about the successes. Dr. Rana McKay: Stepping back, let's just talk about like the principles and design of ADCs. So, most ADCs have three components. There's a monoclonal antibody that typically targets a cell surface antigen, which is conjugated by a linker, which is the second component, to a payload drug. And typically, that payload drug has been chemotherapy, whether it be topoisomerase or whether it be MMAE or other chemotherapeutic. We can start in the RCC space. There's been multiple antibody-drug conjugates that have been tested. There's antibody-drug conjugates to CD70, which is expressed on clear cell RCC. There's been antibody-drug conjugates to ENPP3, which is also expressed on RCC. There's antibody-drug conjugates to CDH6. And they have different payloads, like I said, whether it be topoisomerase I or other microtubule inhibitors. Now, when we think about kidney cancer, we don't treat this disease with chemotherapy. This disease is treated with immunotherapy. It is treated with treatments that target the VEGF pathway and historically has not been sensitive to chemo. So, I think even though the targets have been very exciting, we've seen very underwhelming data regarding activity, and in some context, seen increased toxicity with the ADCs. So, I think we need to tread lightly in the context of the integration and the testing of ADCs in RCC. We just came back from the KCRS meeting, and there was some very intriguing data about a c-Kit ADC that's being developed for chromophobe RCC, which is, you know, a huge unmet need, these variant tumors that really lack appropriate therapeutics. But I just caution us to tread lightly around how can we optimize the payload to make sure that the tumor that we're treating is actually sensitive to the agent that's targeting the cell kill. So, that's a little bit on the ADCs in RCC. I still think we have a long way to go and still in early testing. Now, ADCs for UC are now the standard of care. I think the prototypical agent, enfortumab vedotin, is a nectin-4-directed ADC that's conjugated to an MMAE payload and was the first ADC approved for advanced urothelial, received accelerated approval following the EV-201 trial, which was basically a multicenter, single-arm study that was investigating EV in cisplatin-ineligible patients with advanced urothelial carcinoma, and then ultimately confirmed in the EV-301 study as well. And so, that study ended up demonstrating the support superiority of EV from an overall survival standpoint, even PFS standpoint. Building on that backbone is the EV-302 study, which tested EV in combination with pembrolizumab versus platinum-based chemotherapy in the frontline setting. And that was a pivotal, landmark study that, like I said, has displaced platinum therapy as a frontline treatment for people with advanced urothelial carcinoma. And when we think about that study and the median overall survival and just how far we've come in urothelial cancer, the median OS with EV-pembro from that trial was 31 and a half months. I mean, that's just incredible. The control arm survival was 16 and a half months. The hazard ratio for OS, 0.47. I mean this is why when this data was presented, it was literally a standing ovation that lasted for several minutes because we just haven't seen data that have looked that good. And there are other antibody-drug conjugates that are being tested. We've all been involved in the saga with sacituzumab govitecan, which is a trophoblast cell surface antigen 2 (Trop-2) targeted ADC with a topoisomerase I payload. It was the second ADC to receive approval, but then that approval was subsequently withdrawn when the confirmatory phase 3 was negative, the TROPiCS-04 trial. So, approval was granted based off of the TROPHY-U-01, single-arm, phase 2 study, demonstrating a response rate of around 28% and a PFS of, you know, about 5 and a half months. But then failure to show any benefit from an OS standpoint. And I think there's a lot of controversy in the field around whether this agent still has a role in advanced urothelial carcinoma. And I think particularly for individuals who do not have molecular targets, like they're not HER2-amplified or have HER2-positivity or FGFR or other things like that. Dr. Pedro Barata: Fantastic summary, Rana. You were talking about the EV, and it came to mind that it might not be over, right, for the number of ADCs we use in clinical practice in the near future. I mean, we've seen very promising data for ADC against the HER2, right, and over-expression. It also can create some challenges, right, in the clinics because we're asking to test for HER2 expression. It's almost like, it's not exactly the same to do it in breast cancer, but it looks one more time that we're a little bit behind the breast cancer field in a lot of angles. And also has vedotin as a payload. Of course, I'm referring to disitamab vedotin, and there's very elegant data described by you in your review chapter as well. And it's going to be very interesting to see how we sequence the different ADCs, to your point as well. So, before we wrap it up, I just want to give you the opportunity to tell us if there's any area that we have not touched, any take-home points you'd like to bring up for our listeners before we call it a day. Dr. Rana McKay: Thank you so much. I have to say, you know, I was so excited at ASCO this year looking at the GU program. It was fantastic to see the progress being made, novel therapeutics that really there's a tremendous excitement about, not just in RCC and in UC, but also in prostate cancer, thinking about the integration of therapies, not just for people with refractory disease that, even though our goal is to improve survival, our likelihood of cure is low, but also thinking about how do we integrate these therapies early in the treatment landscape to enhance cure rates for patients, which is just really spectacular. We're seeing many of these agents move into the perioperative setting or in combination with radiation for localized disease. And then the special symposium on biomarkers, I mean, we've really come a long, long way. And I think that we're going to continue to evolve over the next several years. I'm super excited about where the field is going in the treatment of genitourinary malignancies. Dr. Pedro Barata: Oh, absolutely true. And I would say within the Annual Meeting, we have outstanding Educational Sessions. And just a reminder to the listeners that actually that's where the different teams or topics for the Educational Book chapters come from, from actually the educational sessions from ASCO. And your fantastic chapter is an example of that, right, focusing on advanced GU tumors. So, thank you so much, Rana, for taking the time, sharing your insights with us today on the podcast. It was a fantastic conversation as always. Dr. Rana McKay: My pleasure. Thanks so much for having me, Dr. Barata. Dr. Pedro Barata: Of course. And thank you to our listeners for your time today. You will find the link to the article discussed today in the transcript of this episode. I also encourage you to check out the 2025 ASCO Educational Book. You'll find an incredible wealth of information there. It's free, available online, and you'll find, hopefully, super, super important information on the key science and issues that are shaping modern oncology, as we've heard from Dr. McKay and many other outstanding authors. So, thank you, everyone, and I hope to see you soon. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Follow today's speakers: Dr. Pedro Barata @PBarataMD Dr. Rana McKay @DrRanaMcKay Follow ASCO on social media: @ASCO on X (formerly Twitter) ASCO on Bluesky ASCO on Facebook ASCO on LinkedIn Disclosures: Dr. Pedro Barata: Stock and Other Ownership Interests: Luminate Medical Honoraria: UroToday Consulting or Advisory Role: Bayer, BMS, Pfizer, EMD Serono, Eisai, Caris Life Sciences, AstraZeneca, Exelixis, AVEO, Merck, Ipson, Astellas Medivation, Novartis, Dendreon Speakers' Bureau: AstraZeneca, Merck, Caris Life Sciences, Bayer, Pfizer/Astellas Research Funding (Inst.): Exelixis, Blue Earth, AVEO, Pfizer, Merck Dr. Rana McKay: Consulting or Advisory Role: Janssen, Novartis, Tempus, Pfizer, Astellas Medivation, Dendreon, Bayer, Sanofi, Vividion, Calithera, Caris Life Sciences, Sorrento Therapeutics, AVEO, Seattle Genetics, Telix, Eli Lilly, Blue Earth Diagnostics, Ambrx, Sumitomo Pharma Oncology, Esiai, NeoMorph, Arcus Biosciences, Daiichi Sankyo, Exelixis, Bristol Myers Squibb, Merck, Astrazeneca, Myovant Research Funding (Inst.): Bayer, Tempus, AstraZeneca, Exelixis, Bristol Myers Squibb, Oncternal Therapeutics, Artera
Devotion IX - Choices - Josh. 24:15
Our hosts have plenty of energy and stuff to talk about following Benjamin's road-trip vacation. After Benjamin's discussion of hot dog prices and charitable clowns, this weeks show starts off with a review of the 2026 BMW iX xDrive60. With over 350 miles of range on tap, this EV should have been the perfect chariot for a road trip, but Benjamin did have a few issues along his trip. Additionally, the guys go into a deep discussion about carbon fiber, clamshell hoods, and other premium EVs. Then Sami goes nuts over news following this year's Monterey Car Week and Pebble Beach Concours. From Lexus to Infiniti to Nissan and BMW, there's all kinds of fun news to pour over, and laugh about. Thanks for listening!
La pimienta es hoy un condimento muy común y de precio asequible, esencial en cocinas de todo el mundo, pero no siempre fue así. Proviene de la región de Malabar, en el sur de la India y se convirtió en un importante motor de la economía y el comercio durante miles de años. Desde la antigüedad, la pimienta fue un producto valioso y muy demandado. En el Egipto de los faraones se usaba en la cocina, pero también en ritos de momificación tal y como los arqueólogos pudieron comprobar cuando encontraron dos granos de pimienta en las fosas nasales de la momia de Ramsés II. De Egipto pasó a otras zonas del Mediterráneo. En Grecia era bien conocida, pero su alto coste limitaba su consumo a los que eran muy ricos. Debía ser tan cara que no aparece ni siquiera mencionada en el antiguo testamento Su escasez se debía a que había que traerla desde la India mediante una ruta muy larga que iba por el mar Rojo y el mar Arábigo. Se desconocía, además, de que planta en concreto provenía. En tiempos del Imperio Romano ese comercio se expandió como nunca antes. Los romanos, que habían creado una gran zona comercial en el Mediterráneo, importaron durante siglos grandes cantidades de pimienta que transformó su gastronomía y la economía del imperio. La conquista romana de Egipto en el 30 a.C. les abrió el mar Rojo de par en par. Eso les facilitaba el acceso directo a la India. De como las flotas romanas llegaban hasta la India da fe un diario de viaje del siglo I, el "Periplo del mar eritreo", en el que el autor detalla las rutas comerciales, los puertos de recalada y los productos con los que había que comerciar. La pimienta siguió siendo costosa, pero su preció descendió, lo que hizo de esta especia un condimento muy popular en la Roma imperial. Tras la caída del imperio romano, bizantinos, persas y árabes se fueron sucediendo en el control del comercio con la India. En el siglo IX, los árabes ya eran los dueños de la ruta entre los puertos indios de Malabar y los del golfo Pérsico y el mar Rojo. La pimienta se integró en la cocina islámica y fue incluso elogiada por eruditos como Avicena. Una vez en las costas del Mediterráneo, venecianos y genoveses monopolizaban su distribución. Su escasez la convirtió en uno de los símbolos de riqueza más visibles de la Europa medieval. Los reyes y aristócratas la empleaban en la cocina y trataban de que sus existencias de pimienta fuesen muy visibles en los banquetes. Cualquiera con dinero estaba dispuesto a pagar por ella, algo que hizo prosperar a las repúblicas marítimas italianas que se encargaban de traerla desde los puertos del Levante. La caída de Constantinopla en 1453 encareció aún más el producto porque los otomanos elevaron los peajes. Eso empujó a los portugueses, que ya estaban explorando la costa africana, a buscar rutas alternativas. En 1498 Vasco da Gama llegó a Calicut acabando así con el monopolio que durante siglos habían tenido árabes y venecianos. Durante más de un siglo los portugueses establecieron en la India factorías fortificadas como la de Goa, desde donde controlaban el comercio de pimienta ahuyentado a los competidores. Eso redujo sustancialmente los precios en Europa ya que se eliminaban los intermediarios. Se llevaron también su cultivo a Brasil, lo que redundó en un incremento de la oferta. Pero seguía siendo interesante desde el punto de vista comercial, por lo que otras potencias como los Países Bajos, Inglaterra y Francia entraron en el mercado con sus compañías de las Indias Orientales. En sólo unas décadas consiguieron que llegase tanta pimienta a los mercados europeos que su precio descendió hasta convertir la otrora deseada especia en una commodity más. En el siglo XVIII la pimienta ya era algo cotidiano, pero había conseguido cambiar el mundo. Gracias a ella prosperaron ciudades como Lisboa y Ámsterdam, los beneficios obtenidos por su venta financiaron todo tipo de innovaciones y fue la palanca que los europeos utilizaron para establecerse en Asia hasta bien entrado el siglo XX. En El ContraSello: 0:00 Introducción 4:21 El imperio de la pimienta 1:08:49 Vlad Tepes "el empalador" 1:17:51 ¿Qué sabían los alemanes del Holocausto?" Bibliografía: “Las especias: Historia de una tentación” de Jack Turner - https://amzn.to/3HWOGng “Especias” de Roger Crowley - https://amzn.to/4n2GqB5 “Historia de las especias” de Román Hereter - https://amzn.to/3JFekxk “El origen de las especias” de Thomas Reinerstensen - https://amzn.to/4209GQR #FernandoDiazVillanueva #pimienta #especias Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals
Customer service used to be seen as a cost center. Something to manage, streamline, and, if possible, outsource or automate. But what happens when AI shifts that narrative entirely? In this episode of Tech Talks Daily, I sat down with Ryan Peterson, Chief Product Officer at Concentrix, to unpack how customer service is being reimagined as a revenue-driving engine. With 430,000 advisors handling millions of calls for brands across every major industry, Concentrix isn't theorizing about the future. They're building it. Ryan shares how blending human empathy with AI efficiency is creating faster resolutions, stronger loyalty, and in some cases, serious bottom-line results. One example saw upsell revenue rise from $500,000 to $1.6 million per month simply by supporting human agents with smart, context-aware AI assistants. We also talk about the evolution of the agent's role. Far from replacing jobs, AI is creating a new class of specialists called agent engineers. These are people responsible for maintaining, optimizing, and guiding AI systems that now work alongside human teams. This shift is opening doors for deeper personalization, real-time translation, and richer customer engagement across channels and geographies. Ryan also gives us a behind-the-scenes look at Concentrix's award-winning IX...Low Platform, which was recently named Intelligent Personal Assistant of the Year. Supporting over 7,000 AI agents and offering robust security and integration capabilities, the platform is designed for scale and resilience. It's not just handling simple FAQs. From legal contract analysis to proactive service interventions, these AI agents are transforming how enterprise support works. We close with a forward-looking conversation about hyper-personalization, ethical AI integration, and the long-term role of trust in CX strategy. Ryan's optimism is clear, but it's grounded in metrics, use cases, and a deep understanding of what businesses actually need to deliver meaningful customer experiences. If you're curious about what customer service looks like when AI and humans collaborate effectively, or what it takes to move from handling complaints to driving conversion, this is the conversation you'll want to hear.
Desde Montserrat, el macizo montañoso que fascina y embruja, la montaña mágico sagrada de Cataluña, marcada por la leyenda, el hallazgo de una Virgen Negra tras la aparición de unas extrañas luces en los cielos en el siglo IX, la Virgen de Montserrat, La Moreneta, hoy en La España Mágica de Más de Uno nuestro compañero Fran Contreras nos desvela, junto al escritor y periodista Javier Sierra, las claves y secretos de su nueva novela: El Plan Maestro, publicado por la Editorial Planeta, cuatrocientas ochenta y cinco páginas, que nos invita a descubrir los secretos del arte.
La leyenda de la papisa Juana cuenta la historia de una mujer que, en el siglo IX, habría ascendido al papado bajo el nombre de Juan VIII, disfrazada de hombre. Según el relato, Juana, nacida en Maguncia, destacó desde joven por su inteligencia y ansias de conocimiento. En una época donde la educación estaba reservada a los hombres, se dice que se disfrazó para ingresar a un monasterio y luego estudiar en Atenas. Su erudición la llevó a Roma, donde, bajo apariencia masculina, escaló en la jerarquía eclesiástica hasta ser elegida papa. La historia culmina con un desenlace trágico: durante una procesión, Juana dio a luz, revelando su verdadera identidad. Indignada, la multitud la habría ejecutado. Aunque fascinante, esta historia carece de sustento histórica. Los primeros registros aparecen en crónicas del siglo XIII, como la de Martín de Opava, y muchos historiadores consideran que es un mito creado para satirizar a la Iglesia o reflejar tensiones políticas de la época. · Canal de Telegram: https://t.me/lacontracronica · “Contra la Revolución Francesa”… https://amzn.to/4aF0LpZ · “Hispanos. Breve historia de los pueblos de habla hispana”… https://amzn.to/428js1G · “La ContraHistoria de España. Auge, caída y vuelta a empezar de un país en 28 episodios”… https://amzn.to/3kXcZ6i · “Lutero, Calvino y Trento, la Reforma que no fue”… https://amzn.to/3shKOlK · “La ContraHistoria del comunismo”… https://amzn.to/39QP2KE Apoya La Contra en: · Patreon... https://www.patreon.com/diazvillanueva · iVoox... https://www.ivoox.com/podcast-contracronica_sq_f1267769_1.html · Paypal... https://www.paypal.me/diazvillanueva Sígueme en: · Web... https://diazvillanueva.com · Twitter... https://twitter.com/diazvillanueva · Facebook... https://www.facebook.com/fernandodiazvillanueva1/ · Instagram... https://www.instagram.com/diazvillanueva · Linkedin… https://www.linkedin.com/in/fernando-d%C3%ADaz-villanueva-7303865/ · Flickr... https://www.flickr.com/photos/147276463@N05/?/ · Pinterest... https://www.pinterest.com/fernandodiazvillanueva Encuentra mis libros en: · Amazon... https://www.amazon.es/Fernando-Diaz-Villanueva/e/B00J2ASBXM Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals