Podcasts about Zdenka

Domišljavi plastični obešalnik je vseskozi žalil lesene obešalnike … Pripovedujeta: Judita Zidar in Boris Ostan. Napisal: Zdenek Sverak. Avtor prevoda: Zdenka Škerlj Jerman. Posneto v studiih Radia Slovenija 2001.

Gibanje Pot in Vinko Kobal, s katerim se je srečala že v gimnazijskih letih, je pomembno zaznamovalo njeno življenje in ga bogati še danes – 50 let kasneje. In zanimivo, da ji tudi hoja zelo veliko pomeni in so pohodi: blizu in daleč pravzaprav njen vsakdan. Zdenka Žigon, raziskovalka dežel in usod ljudi – kot etnologinja in zgodovinarka, pa tudi socialna delavka, je predvsem predana knjigam in branju. Svojčas je bila direktorica Lavričeve knjižnice v Ajdovščini, knjigam in branju pa zavezana prej in potem – še zdaj. Njena prizadevanja za razvijanje bibliotekarske stroke so prepoznali tudi v Zvezi bibliotekarskih društev Slovenije in leta 2009 je za svoje delo prejela Čopovo diplomo. Tudi po upokojitvi je izredno dejavna; med drugim v društvu Most, kjer z najrazličnejšimi študijskimi krožki bogatijo življenje ljudem v tretjem življenjskem obdobju. Zdenka Žigon je strastna bralka, ki je s številni bralnimi projekti svoj zanos delila na vse generacije in različne, tudi ranljive skupine.

Je starko skrbelo za Snežico ali je bila samo zelo radovedna. Tako radovedna, da je prelomila obljubo. Kaj se je zgodilo, izveš v japonski pravljici Beli žerjav. Še nekaj morda neznanih besed: Žerjav je velika ptica z dolgim vratom, dolgimi golimi nogami in navadno sivim perjem, v tej pravljici pa ima snežobelo perje. Snop je večji šop povezanega požetega žita sli slame v tej pravljici pa je to šop vej kolikor jih lahko neseš. Statve so priprava za tjanje blaga iz preje Preja je nit, spredena iz krajših ali daljših vlaken naravnega ali umetnega izvora: Prisluhni. Vir: Zlata ptica, Najlepša pahljača, japonske pravljice, prevedla Zdenka Škerlj Jerman, Mladinska knjiga 1996, Ljubljana, bere Nataša Holy

V Den české státnosti se opět uskutečnil v Areálu čs.opevnění v bunkru Alej v Darkovičkách pietní akt za Jana Poláška, nestora československé bunkrologie, velkého vlastence. Hold a úctu mu přišel vzdát mezi jinými i jeho syn Jan či manželé Zdenka a Vladan Pfefferovi.Všechny díly podcastu Odpolední interview můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

V Den české státnosti se opět uskutečnil v Areálu čs.opevnění v bunkru Alej v Darkovičkách pietní akt za Jana Poláška, nestora československé bunkrologie, velkého vlastence. Hold a úctu mu přišel vzdát mezi jinými i jeho syn Jan či manželé Zdenka a Vladan Pfefferovi.

Víte, co se skrývá pod pojmem společenská odpovědnost organizací nebo co dělá manažer kvality? Do zákulisí tzv. neviditelné profese nás zavede vysokoškolská pedagožka Zdenka Hofbruckerová z VŠB-TUO.Všechny díly podcastu Odpolední interview můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

The Dean's List with Host Dean Bowen – In an eye-opening conversation with Zdenka Alexova, she recounts her experiences growing up under the oppressive grip of Communism in Czechoslovakia. From government control to the suppression of creativity and thought, Zdenka's story sheds light on the dark realities of life behind the Iron Curtain and the enduring impact of Marxist ideology on society.

MHD zdarma jako poděkování za službu v uniformě. Chrudim zavedla nový benefit pro válečné veterány. Bývalí vojáci můžou bezplatně cestovat hromadnou dopravou. Radnice se tak snaží aspoň symbolicky ocenit jejich práci.

Ihr Name ist heute vor allem unter Gesangsstudierenden eine Institution für sich. Nicht wenige Sopranistinnen hat sie in der Berliner Universität der Künste hervorgebracht und ihnen zu einer erfolgreichen Sängerkarriere verholfen, die sie selbst einst innehatte. Ihren deutschsprachigen Wurzeln folgend wagte sie jung den Weg von Amerika nach Europa, um sich auf dem hart umkämpften Sängermarkt zu etablieren. Der Weg sollte kein leichter werden, doch nicht wenige Zweifler belehrte sie bald eines Besseren. Die Bayerische Staatsoper in München wurde ihr künstlerisches Zuhause, wo sie in Partien wie Despina, Zdenka, Sophie, Musetta und Susanna Maßstäbe setzte und die sie schließlich auch auf den großen, internationalen Bühnen verkörpern durfte. Zeitgenössische Komponisten wie Aribert Reimann wissen ihre Kunst auch als Konzertsängerin zu schätzen und widmen ihr maßgeschneiderte Werke. Wieso man beim Studieren neuer Werke manchmal eine Woche an nur zwei Takten übt, wie schwer es sein kann, im Vorsingen sein volles Potential zeigen können und was Singen und Betrunkensein gemeinsam haben, davon berichtet die amerikanische Sopranistin und erfolgreiche Gesangsprofessorin Julie Kaufmann.

Předposlední část série Ladies nabízí v talkshow No filteru rozhovor se Zdenkou Michalkovou. Na její život, práci i rodičovství se z pozice moderátora neptá její manžel Milan, ale někdo docela jiný.

Z hromadné dopravy na autobus nebo vlak na jednu jízdenku. To je hlavní změna, která čeká cestující, kteří využívají MHD v Chrudimi. Zhruba za dva měsíce se zapojí do systému IREDO, který sdružuje přepravce v Pardubickém a Královéhradeckém kraji.

Piše Katarina Mahnič, bereta Lidija Hartman in Matjaž Romih. Barbara Cerar, odlična gledališka in filmska igralka, prvakinja ljubljanskega Slovenskega narodnega gledališča Drama, je v svojem prvem pisateljskem poskusu Pretežno jasno. tako suverena kot na odru – vsebinsko in jezikovno briljantna, sveža in inovativna, neznansko smešna, sočutno ganljiva in pišmeuhovsko razbrzdana, z velikim uvidom v vse, kar je človeško. Končno je nekdo na Slovenskem napisal kratkočasno knjigo o spopadanju z banalnostmi življenjskega vsakdana, ne da bi bili protagonisti zafilozofirani intelektualci, blodnjavi uživalci droge ali raznorazni socialni problemi z neozdravljivimi travmami iz otroštva. Čeprav se Cerarjeva ves čas sprehaja po tanki meji med lahkotnim plažnim branjem in posrečeno različico razvojnega romana, to teže njenega dela nikakor ne zmanjša. Glavno junakinjo, disleksično tridesetinnekajletno Olgo Vrabec Golob, je zapustil mož in tako je na vsem lepem spet svobodno prepuščena svoji neukrotljivi miselni akrobatiki in precej posebni domišljiji, ki v njen obup vnašata pretiravanje, samoironijo in sproščujoč humor. Brez pridiganja, zgražanja in zavor najbližjih – starši so ji tragično umrli že v gimnaziji, teta Zdenka, ki ji je bila določena za skrbnico, živi v Parizu, mož Tom jo je popihal z drugo – priplava na površje njen edinstveni samoohranitveni nagon, pa tudi zmožnost za sprejemanje vtikljivih sosedov, s katerimi se prej niti v sanjah ne bi družila, pravzaprav so ji bili celo zoprni. Tukaj so Karla, polna dobronamernih nasvetov, ki poleg vedeževanja obvlada vrtnarjenje, manikuro, pedikuro, mimogrede kakšnega “spoha” in je za povrh še teta Tomove ljubice Karoline, pa Rezka, starejša gospa, ki s svojimi pečenimi dobrotami hodi v bolnišnico tolažit čakajoče, in butasti blebetač Roki, na katerega Olga sploh ne gleda kot na moškega. Šopek posebnežev, ki ga dopolnjuje še kup drugih akterjev, bi lahko ob manj spretnem peresu hitro zapadel v karikaturo, vse kar se dogaja z njimi, pa v burkaško farso, namenjeno smehu in ničemur globljemu. Tako pa se ob branju sicer zavedaš, da takšni empatični, vedno na pomoč in akcijo pripravljeni sosedje ne obstajajo, a jim vendarle verjameš do zadnje pičice, tako kot otrok noče nehati verjeti v Božička. Pestijo jih vsem znane tegobe, le da so namesto tarnanja iz njih naredili “žur”. To je v bistvu glavni adut romana Pretežno jasno – da je kljub neverjetnosti čisto verjeten in kljub neresnosti še kako zaresen. Seveda poleg živahno nagnetenega jezika in unikatnih primer: “misel jo je napadla kot roj lačnih tigrastih komarjev v mraku, ko greš zalivat vrt” ali “ena sama sosedina govorna diareja je razblinila vse čudovite prizore” ali “črke so preskakovale ena drugo, kot da pri telovadbi skačejo čez kozo” … Posebno barvitost mu dajejo nenavadni in slikoviti, skoraj dramaturško naštudirani prizori – prispodobe, s katerimi si Olga v svoji disleksični maniri začini in lajša težke trenutke ali neprijetne misli. Kot na primer tista, ko se odloči zmetati stran stvari prešuštnega moža. “V tem filmu je bila ona glavna junakinja, ki pleše po stopnicah, imela je s kano poslikane roke in nakit v obliki trikotnika od leve nosnice do levega ušesa. Okoli nje so plesali stasiti mladci golih torzov in gladkih hrbtov, saj kosmatih res ni marala. Trzajoč z zadnjicami so priplesali na dvorišče, ona je v sredini – pojoč refren – zagrabila težko vrečo in jo odvlekla do smetnjaka. Mladci so kot v šamanskem obredju poskakujoč okoli nje dvignili vrečo in jo vrgli v smetnjak. Seveda v sosedovega, saj ni neumna.” Ob tem početju jo zagleda soseda Rezka, ki kar ne more nehati buljiti v prepoteno sosedo v spodnjih hlačah, zgornjem delu pižame s srčki in supergah, sploh ker je bila že pozna jesen. In ravno na tem mestu me je obšlo, da je Olga Vrabec Golob s svojo prostodušnostjo in nerodnostjo podobna Bridget Jones, ki jo je upodobila pisateljica Helen Fielding, prav tako pa sem se ob branju spomnila kultnega postmodernističnega romana Dubravke Ugrešić Štefica Cvek v krempljih življenja in romana Panika Dese Muck. Samih žlahtnih ženskih pripovedi torej. Pa vendar Barbara Cerar, ki je svojemu izjemnemu učitelju slovenščine obljubila, da bo nekoč napisala roman, in se obljube tudi držala, ostaja prepoznavno svoja. Dragocena knjiga o iskanju sebe, ljubezni in pristnih medčloveških odnosih skozi humorne zaplete predstavi tudi grenkejšo plat človekovega bivanja: drugačnost, osamljenost, bolezen, smrt … in tisto, česar se naučimo, ko že nekaj doživimo – zmožnost razumevanja in odpuščanja. Ob branju se počutiš, kot da gledaš skozi kalejdoskop, kjer barvna ogledalca nenehno spreminjajo podobe, na katerih se med svetle barve mešajo tudi temne. A skozi ene in druge vedno preseva svetloba. Pretežno jasno je, kljub pretežni vremenski napovedi v naslovu, sončna knjiga.

Da dobrota in poštenost vedno zmagata, je pomembna značilnost ljudskih pripovedk. Tudi japonska pravljica Čez poštenje ga ni pripoveduje o tem, da se grdi naklepi sprevržejo v posmeh tistemu, ki slabo misli. Poštenjak je sanjal, da mu bogovi z neba pošiljajo zlatnike. In kako prav je imel! Zlata ptica, Najlepša pahljača, japonske pravljice, prevedla Zdenka Škerlj Jerman, Mladinska knjiga 1996, Ljubljana, bere Nataša Holy

"Killer stuff! Sounds huge! " Paul Yee, Engineer/Producer/Musician, Stereobus Recording "Spectacular production. Breathtaking!" Michael Gillespie "The album was always world-class, but the restoration is beautiful. I was literally overcome. The album is sooooo good!!!." Laurie Mackenzie "What an amazing band!!! Well done." Gord Osland "BRAVO!, Stellar Sound, Unbelievable Voice, Heartfelt Lyrics. Wonderful Memories." LA "Bob's voice riding on top of these amazing pieces of music. Great playing Glen, Danny, Greg, Steve, Brian and Bob. Sounds great Glenn A. A Gem!." Sandy Chochinov "I do a lot of listening and am somewhat of an audiophile and the album I heard is as good and generally better than some very highly regarded current "audiophile" quality pop albums." Greg Black. "One of Canada's truly best musical units." Daniel Joseph Casavant "Spent many an enjoyable and very late night at Roade Recording with these fine musicians. Ahead of the curve, inventive and definitely worth listening to." Howard Gurevich "I'm loving the sound production and it's such a thrill to hear these wonderful songs again.", Terry Read "It is a very interesting and bold collection of music." Danny Pelfry "Sounds fabulous! I'm hearing stuff in the tracks I didn't even know where there!" Steve Hegyi​

V zadnji epizodi sklopa predvajanja nagrajenih literarnih prispevkov na natečaju Od solz do smeha z demenco, bomo slišali pesem Alferije Bržan. dr. Zdenka Čebašek Travnik jo bo opremila s strokovnimi komenatarji in mislimo o pomenu literarnega ustvarjanja, ko se naših življenj dotakne demenca.

Liberecká výtvarnice a bývalá rozhlasová redaktorka Zdenka Schovánková používá na svých barevných obrazech nezvyklou techniku. Spojuje titěrnou kresbu s malbou. Výstavu jejich nejnovějších prací hostí Malé divadlo v Liberci.Všechny díly podcastu Vybrali jsme pro vás můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

Liberecká výtvarnice a bývalá rozhlasová redaktorka Zdenka Schovánková používá na svých barevných obrazech nezvyklou techniku. Spojuje titěrnou kresbu s malbou. Výstavu jejich nejnovějších prací hostí Malé divadlo v Liberci.

Jak vypadají inspirativní knihovny dneška? Cyklus nahlíží za dveře institucí, které získaly ocenění Bibliotheca inspirans 2023, protože ukázaly, že jsou nejen půjčovnou literatury, ale bezpečným přístavem, místem setkání a upevnění komunity.Všechny díly podcastu Mozaika můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

Nikdy nevíte, na které stránce se vám Paříž otevře, s kým z živých nebo mrtvých se tam potkáte. Já se v ní před několika dny setkala se svojí babičkou. Byla jsem tam na otočku, záminkou byl večírek česky hovořících „kulturních pracovníků“ na velvyslanectví v rue Charles Floquet, ve stínu Eiffelovy věže.

Nikdy nevíte, na které stránce se vám Paříž otevře, s kým z živých nebo mrtvých se tam potkáte. Já se v ní před několika dny setkala se svojí babičkou. Byla jsem tam na otočku, záminkou byl večírek česky hovořících „kulturních pracovníků“ na velvyslanectví v rue Charles Floquet, ve stínu Eiffelovy věže.Všechny díly podcastu Ranní úvaha můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

Zdenka Koláriková vyrastala v rodine, ktorá už od tridsiatych rokov minulého storočia verila myšlienkam komunizmu. S manželom Michalom v roku 1968 verejne prejavili nesúhlas s okupáciou Československa a následne sa stali obeťami normalizácie: stratili zamestnanie i možnosť pracovať vo svojom odbore, boli vylúčení z komunistickej strany, ich synovia mali problémy s prihláškami na stredné i vysoké školy. Napriek tomu svoj postoj nikdy nezmenili a pohybovali sa v slovenskom disidentskom prostredí.

Zdenka Bergrová, básnířka a překladatelka, se narodila 10. března 1923. Básně jsou ze sbírky Praha je pečeť, vydalo nakladatelství ASTRA v roce 1990. Podcast "Báseň na každý den" poslouchejte na Spotify, Apple, Google, YouRadio, České Podcasty nebo Audiolibrix. Domovská stránka podcastu je na ⁠https://www.poetickyklub.cz⁠. Odebírejte novinky Poetického klubu do e-mailu.

Dramatický príbeh lásky z obdobia druhej svetovej vojny, ktorého rozuzlenie siaha až do súčasnosti... Viac povie autorka Zdenka Beckerová. Kniha Už bude pol dvanástej: https://www.bux.sk/knihy/668073-uz-bude-pol-dvanastej.html 

Energie, čas a důslednost jsou tři základní důležité věci, aby rodina tvořila tým, který táhne za jeden provaz. Více praktických rad i zkušeností nabídnou manželé Zdenka a Roman Neumannovi v podcastu Štafeta. Nad to je důležitý pozitivní postoj navzdory "těžkým časům". Všechno vychází ze vztahu manželů, to je základ rodinného týmu. Děti v něm ale mají důležitou roli, mají mít svá práva i povinnosti. Potřebují bezpečné láskyplné prostředí, ve kterém se mohou dobře rozvíjet a zároveň potřebují disciplínu.

The town of Longyearbyen in the high Arctic is the world's northernmost settlement. Here, climate change is happening fast. It is clearly seen and sensed by the locals; with higher temperatures, more rain and permafrost thaw. At the same time, the town is shifting from state-controlled coal production to tourism, research, and development, rapidly globalizing, with numerous languages spoken, cruise ships sounding the horn in the harbor, and planes landing and taking off. Zdenka Sokolíčková lived here between 2019-2021, and her research in the community uncovered a story about the conflict between sustainability and the driving forces of politics and economy in the rich global North. A small town of 2,400 inhabitants at 78 degrees latitude north on the Norwegian archipelago of Svalbard, Longyearbyen provided a unique view into the unmistakable relationship between global capitalism and climate change.  The Paradox of Svalbard: Climate Change and Globalisation in the Arctic (Pluto Press, 2023) looks at both local and global trends to access a deep understanding of the effects of tourism, immigration, labor, and many other elements on the trajectory of the climate crisis, and whether anything can be done to reverse them. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

The town of Longyearbyen in the high Arctic is the world's northernmost settlement. Here, climate change is happening fast. It is clearly seen and sensed by the locals; with higher temperatures, more rain and permafrost thaw. At the same time, the town is shifting from state-controlled coal production to tourism, research, and development, rapidly globalizing, with numerous languages spoken, cruise ships sounding the horn in the harbor, and planes landing and taking off. Zdenka Sokolíčková lived here between 2019-2021, and her research in the community uncovered a story about the conflict between sustainability and the driving forces of politics and economy in the rich global North. A small town of 2,400 inhabitants at 78 degrees latitude north on the Norwegian archipelago of Svalbard, Longyearbyen provided a unique view into the unmistakable relationship between global capitalism and climate change.  The Paradox of Svalbard: Climate Change and Globalisation in the Arctic (Pluto Press, 2023) looks at both local and global trends to access a deep understanding of the effects of tourism, immigration, labor, and many other elements on the trajectory of the climate crisis, and whether anything can be done to reverse them. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/world-affairs

The town of Longyearbyen in the high Arctic is the world's northernmost settlement. Here, climate change is happening fast. It is clearly seen and sensed by the locals; with higher temperatures, more rain and permafrost thaw. At the same time, the town is shifting from state-controlled coal production to tourism, research, and development, rapidly globalizing, with numerous languages spoken, cruise ships sounding the horn in the harbor, and planes landing and taking off. Zdenka Sokolíčková lived here between 2019-2021, and her research in the community uncovered a story about the conflict between sustainability and the driving forces of politics and economy in the rich global North. A small town of 2,400 inhabitants at 78 degrees latitude north on the Norwegian archipelago of Svalbard, Longyearbyen provided a unique view into the unmistakable relationship between global capitalism and climate change.  The Paradox of Svalbard: Climate Change and Globalisation in the Arctic (Pluto Press, 2023) looks at both local and global trends to access a deep understanding of the effects of tourism, immigration, labor, and many other elements on the trajectory of the climate crisis, and whether anything can be done to reverse them. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/environmental-studies

The town of Longyearbyen in the high Arctic is the world's northernmost settlement. Here, climate change is happening fast. It is clearly seen and sensed by the locals; with higher temperatures, more rain and permafrost thaw. At the same time, the town is shifting from state-controlled coal production to tourism, research, and development, rapidly globalizing, with numerous languages spoken, cruise ships sounding the horn in the harbor, and planes landing and taking off. Zdenka Sokolíčková lived here between 2019-2021, and her research in the community uncovered a story about the conflict between sustainability and the driving forces of politics and economy in the rich global North. A small town of 2,400 inhabitants at 78 degrees latitude north on the Norwegian archipelago of Svalbard, Longyearbyen provided a unique view into the unmistakable relationship between global capitalism and climate change.  The Paradox of Svalbard: Climate Change and Globalisation in the Arctic (Pluto Press, 2023) looks at both local and global trends to access a deep understanding of the effects of tourism, immigration, labor, and many other elements on the trajectory of the climate crisis, and whether anything can be done to reverse them. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/anthropology

The town of Longyearbyen in the high Arctic is the world's northernmost settlement. Here, climate change is happening fast. It is clearly seen and sensed by the locals; with higher temperatures, more rain and permafrost thaw. At the same time, the town is shifting from state-controlled coal production to tourism, research, and development, rapidly globalizing, with numerous languages spoken, cruise ships sounding the horn in the harbor, and planes landing and taking off. Zdenka Sokolíčková lived here between 2019-2021, and her research in the community uncovered a story about the conflict between sustainability and the driving forces of politics and economy in the rich global North. A small town of 2,400 inhabitants at 78 degrees latitude north on the Norwegian archipelago of Svalbard, Longyearbyen provided a unique view into the unmistakable relationship between global capitalism and climate change.  The Paradox of Svalbard: Climate Change and Globalisation in the Arctic (Pluto Press, 2023) looks at both local and global trends to access a deep understanding of the effects of tourism, immigration, labor, and many other elements on the trajectory of the climate crisis, and whether anything can be done to reverse them. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/geography

"Vděčnost a radost jsou první indikátory toho, jak na tom jsme", uslyšíte ve zbrusu nové sérii pořadu Štafeta, které se pro tento školní rok chopili manželé Zdenka a Roman Neumannovi /nojmanovi/, kazatelský pár Církve bratrské v Pardubicích. Jejich představení i plán témat tohoto podcastu rozvinout v dnešní části.

Včasih je izgovarjanje besede hudič tako zelo resno, da lahko prikliče pravega hudiča In potem je lahko vse narobe. Ali pa prav, kakor se vzame. Kako je s hudičem opravil tesar, izveš v japonski pravljici Tesar in hudič. Zlata ptica, Najlepša pahljača, japonske pravljice, prevedla Zdenka Škerlj Jerman, Mladinska knjiga 1996, Ljubljana, bere Nataša Holy

Nachrichten, Tagesthema, Magazin - EU-Parlament nahm Bericht über strengere Regeln für sich selbst an. Selige Zdenka Schelingová: Vergebung ist das Größte im Leben.

"Nikdy tě neopustím a nikdy se tě nezřeknu." Můžeš si i ty přivlastnit tento Boží slib? Hovoří: Zdenka Prosnerová, ptá se: Kateřina Hodecová

On today's episode, I talk to musician Lindsay Olsen AKA Salami Rose Joe Louis. Originally from San Diego, Lindsay worked in the sciences as a lab tech and made music on the side until Flying Lotus' label Brainfeeder released her third album Zdenka 2080 in 2019, which gave her the courage to pursue music professionally. This was followed up by Chapters of Zdenka the next year, and her most recent, Akousmatikous, was released in May, and it's great! This is the website for Beginnings, subscribe on Apple Podcasts, follow me on Twitter. Check out my free philosophy Substack where I write essays every couple months here and my old casiopop band's lost album here! And the comedy podcast I do with my wife Naomi Couples Therapy can be found here!  

CMM Theology, Bachelor 2023 candidate Zdenka Alexova presents her final work,  "He is Worthy."Going through the beautiful healing process of overcoming fear and discouragement during reading the book of Revelation.  Getting new spiritual eyes and being able to see the glory of Christ and the eternal flame of his victory shining through this book.  Probably the most misunderstood book in the Bible.  Many people has approached the book of Revelation with fear of reading it, because of the fear of the future; not understanding it and causing a false interpretation of this message and causing an inverted view of Jesus Christ himself.Zdenka Alexova invites us to not avoid this book because of it's complexity and to not leave the weightier matter of end times only to biblical scholars and theologians.

S manipulátory se setkáme všude - doma, v práci, ve škole i mezi přáteli. Zajímá Vás, jak je poznat, a jak se jim účinně bránit? Zdenka Tmějová je lektorka, psychoterapeutka a koučka. Absolvovala úspěšně Filozofickou fakultu Univerzity Karlovy v Praze a v oboru pracuje dodnes. Provozuje soukromou terapeutickou praxi a vede semináře zaměřené na osobní rozvoj. Je spoluautorkou knihy ONA a zároveň realizátorkou programu Od manipulace ke svobodě.

Žena v polární noci. To je název nové Četby na pokračování na Dvojce z deníku svérázné umělkyně Christiane Ritterové. „Setkání s autorkou by mě určitě hodně zajímalo. A to nejen proto, že Špicberky se od té doby, kdy ona tam přezimovala, velmi proměnily,“ uvádí antropoložka Zdenka Sokolíčková. Jaký výzkum na Severu prováděla a na jakém projektu pracuje teď? Je milovnicí audioknih? Na co by se Christiane Ritterové zeptala, kdyby žila? Jak se její děti cítily na Špicberkách?Všechny díly podcastu Blízká setkání můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

Umělkyně i teoretička s neobvyklou energií, všestranností a hlubokým vzděláním, ale také s nezměrnou touhou šokovat a provokovat. Ovlivnila mnoho mužů své doby. Některé dokonce podporovala finančně. V dokudramatu účinkují Eva Kodešová, Apolena Veldová či Jan Hofman. Hovoří historička Milena Lenderová.Všechny díly podcastu Osudové ženy můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

In this deeply moving episode from 2020 the New York Times bestselling author Ariana Neuman told her father's extraordinary story for the very first time. Hans Neumann was a young Jewish man from Prague who managed to outwit the Nazis and survive the Holocaust. Ariana Neumann grew up in the Venezuela of the 1970s and 1980s. This was a land of possibility and progress. Her father Hans Neumann - a hugely successful industrialist and patron of the arts – epitomised both these characteristics. But while Hans was outwardly a paragon of success and strength, there were parts of his private self that were unsettling to his close family. He would wake at night screaming in a language his daughter did not understand. He hardly ever mentioned his childhood in central Europe. He never said that he was Jewish. ‘Life,' he would tell his daughter, ‘was to be lived in the present.' On his death in September 2001, Ariana discovered a box of papers and photographs that her father had left her. They became the starting point for a personal investigation into her father's European family and an unspoken history of horrific persecution and enthralling survival during the Holocaust. This episode of Travels Through Time was recorded on the 75th anniversary of the liberation of the Auschwitz death camp in Poland. During the course of this conversation Ariana guides us back to the drama and tragedy of the year 1944: a defining year for the Neumann family of Prague. To see Hans's doll, Zdenka ring and the Jan's identity card – some of the objects discussed during the course of this conversation – please visit our website. When Time Stopped was published internationally in February 2020. It was an instant New York Times Bestseller. Show notes: Scene One: June 23 1944, Red Cross Visit to the Camp of Terezín, CZ. The place is beautified. Thousands are sent to Auschwitz to ease overcrowding and a charade is enacted to fool the International Red Cross inspectors. Scene Two: September 29/30 1944, The arrival of transport EI in Auschwitz, Poland. Scene Three: October 9 1944, Berlin Germany. Hans Neumann has been hiding in plain sight and using a fictitious identity. He receives a summons (issued October 5th) to appear in the Nazi District Court in Prague. Going back to Prague and appearing in court would, almost certainly, mean death. Memento: The sound of Otto Neumann humming the folk song Golem. People/Social Presenter: Peter Moore Guest: Ariana Neumann Producer: Maria Nolan

Herečka a také konferenciérka Laterny magiky Zdenka Procházková si získala publikum doma i v německy mluvících zemích. Znala prkna proslulého vídeňského Burghtheatru, hrála ve filmech, za nejlepší herecký výkon v rozhlasové hře Obchod na korze získala cenu Thálie. O kouzlu její osobnosti v Úžasných životech vypráví její dlouholetý přítel Václav Žmolík.

Še preden vzamemo zalet za skok v naslednje leto, se dajmo za pol urice ustavit še pri letošnjem zadnjem podkastu iz družine Strašno hudi. Mogoče bo tokrat še najbolje, da se usedemo kar za obloženo mizo in se skupaj s Tilnom Travnikom mastimo s pečenko, kakršno ustvarja. Dobesedno ustvarja.Tako da če še iščete ideje za novoletno pojedino … le prisluhnite. Tilen je sicer diplomirani tehnolog živilstva, pa poznavalec konceptov agilnega vodenja in vitkega podjetništva, dolgo javnosti najbolj znan kot soustanovitelj v razvojnem podjetju DLabs. Potem pa se je kot podjetniški mentor pred leti pridružil Luki Sinčku in Maju Hrovatu pri razvoju veganskih pleskavic. Ob prihodu tuje konkurence so to zamisel opustili in se lotili priprave stroja za proizvodnjo mesa iz rastlin, Gre za napravo, s katero sojino moko spremenijo v vlakna in ta vlakna so podobna pustemu govejemu mesu. Od tu naprej recepta ne izdajajo več. “Kako iz pustega mesa pridemo do dobro izgledajočega, dobro dišečega in dobro aromatičnega stejka, to pa je poslovna skrivnost,” se ni dal prepričati Tilen. Povsem razumljivo. Danes namreč želijo v podjetju Juicy Marbles postati globalni igralec na področju rastlinskih različic mesa, kakršna je njihova pljučna pečenka Fillet mignon. Ugriznimo vanjo s Tilnom in poglejmo, kako sočno je njeno stvarjenje.V podkastu se nam je pridružila tudi Tilnova mama, psihiatrinja, po statusu upokojenka, po trenutnih dejavnostih pa svetovalka, Zdenka Čebašek Travnik, ki se še kako dobro spomni poskusov, ki so jih fantje opravljali kar pri njih doma.

Madagaskar je název místa, které rezonuje v dnešní době hlavně ve spojení s animovanou produkcí stejnojmenného filmu pro děti. Skutečný Madagaskar, Malgašsko, je ostrov u afrického kontinentu s tak unikátní faunou i florou, že neustále přitahuje cestovatele z celého světa.  Ale cestovat je jedna věc, trvale zde žít je věc zcela jiná. I na tomto ojedinělém místě, jsem našla velmi zajímavého krajana, který mi nastínil, jak se v tamnější exotice skutečně žije.  Ing. Zdeněk Metelák, úspěšný ředitel francouzské společnosti Société Générale, sídlící v hlavním městě Antananarivo, žije na Madagaskaru se svou rodinou již několik let, proto mi nabídl objektivní pohled na tamnější kraj.O čem jsme hovořili:-       proč se rozhodl pro Madagaskar a prvotní dojmy-       nejznámější krajan Madagaskaru Móric Beňovský-       školský a zdravotní systém v jedné z nejchudších zemí světa-       specifický folklor Madagaskaru-       doporučení a varování pro cestovatele-       co Zdenka naučil život v zahraničí a obzvlášť na Madagaskaru-       co by změnil, kdyby měl možnostPřeji příjemný poslech. :) Jako vždy se budu těšit na vaše komentáře. Sdílejte a pište doporučení na další hosty :)   Buzzsprout - Let's get your podcast launched! Start for FREEDisclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the show Podpořte tvorbu krajanského podcastu přímo v Čechách na této skvělé platformě PICKEY RSS Nebo mi můžete svou podporu prokázat zakoupením kávy v zahraničí na BUYMECOFFEE Připojte se, komentujte, sdílejte a sledujte na Facebooku, Instagramu, Linkedinu, nebo TikToku Chcete mi napsat? Klikněte zde - email

i haven’t forgotten about the math. do you want to do some quick calculations with me?okay, let’s say i listen to 50 albums per week but i accumulate an additional 40 albums every week that i add to the end of the queue. i currently have 6,450 albums in my queue. how many years will it take for me to catch up and start listening to music as it comes out?is this the correct math?: 50x = 6,450 + 40x ; x = 645 weeks / 52 weeks per year = 12.4 years.well, fart. and listening to 50 per week is a high estimate. dang, i guess maybe i need to be more selective?DOWNLOAD/STREAM RECORDING00:00 (intro by omar)00:20 Butter Boys “Let’s Go!” Butter Boys03:57 Hydropark “Calling” Circuit 206:13 SLOUCHER “Be True” Be True09:41 Ruth Garbus “Grey Sweatshirt” Kleinmeister13:06 Sun Organ “HOLE IN MY HEART” SUN ORGAN16:50 Campfires “Candle Park ” Fare Trax19:10 Tundrastomper “How Very Nice” Clean It Up22:35 Inland Island “Happy Birthday Everyone” Salbum II25:50 anxiety machine “manic impressive” sometimes i am overcome by the idea that everything is ruined29:18 Tweens “Cold Shoulder” Incomplete33:28 Emily’s Sassy Lime “Would-Be Saboteurs” Take Heed Desperate, Scared, But Social34:59 salami rose joe louis “Suddenly” Zdenka 208036:45 Sunny Slopes “Keep” Last Exit For Human Kindness33:39 Indira Valey “Haci Te Vas” Yemas42:24 DUMP HIM “Unimportant” Dykes To Watch Out For44:23 Surfin Serf “On The Run” Surface Terminus47:33 Small Axe “hreem” morning drones51:06 Dadweed “I’m Gonna Live Forever” Mighty, Always53:19 Tim The Mute “Scotland” Welcome To The Sad Cafe57:46 Zach Burba “Love Going Wrong” Your Music60:36 Dreamin Wild “Tova” Heaven in Thirty-Eleven63:42 Future Teens “Alone At A Party” Breakup Season67:35 The Groans “Garden Cat” Earth Dweller69:33 TYLER HOLMES “Everything (Will Be Destroyed)” Devil73:49 boy scouts “In Ya Too” Free Company76:32 False Advertising “You’re Too Slow” Brainless79:20 Fountain “Puffed Up” Laughing Through Traffic82:12 Meh “Cycles” Red Kite Crane83:57 Planted “To Music” Pop Music87:23 BOY HARSHER “Westerners” Country Girl Uncut

Hosť podcastu: ZDENA STUDENKOVÁ, herečka Rozprávame sa o jej novej knihe Aj varenie je umenie, v ktorej nájdete vyše 200 receptov a rôzne herecké príbehy, historky a spomienky. Spomienka na prvý kuchársky pokus. Ktoré suroviny nemusí ako kuchárka...ani ako stravníčka? Pani Zdenka je závislá od nakupovania. Tipy, ako zužitkovať zvyšky z chladničky a špajze. Ako jej partner Braňom Kostka chodí nakupovať :-) Spomíname na televízne pondelky. Tiež hovoríme o aktuálnej hre Shirley Valentine. O Poledňákovej filme S tebou mně baví svet, či o Anděl s ďáblem v těle. Druhá časť knihy je plná receptov – celkovo 240 receptov pekne rozdelených. 2 recepty sme vyskúšali a jeden výsledok aj priniesli ochutnať – ako zhodnotí naše mrkvové mafiny Zdena Studenková? Aký je Braňo Kostka stravník? Knihu dopĺňajú úžasné fotografie pani Zdenky v kuchyni + fotky receptov. Pomedzi recepty sú herecké historky – Eva Krížiková, Marína Kráľovičová, Zuzka Kocúriková, Ladislav Chudík, Emil Horváth...a najradšej má pani Zdenka historky s Jožom Vajdom. Ďalšie knižné tipy: Robin Cook exkluzívne o svojej knihe Vírus + úryvok číta Vlado Kobielsky skutočný príbeh Nacisti vedeli, ako sa volám + úryvok číta Zuzana Jurigová Kapráliková Fredrik Backman a jeho Víťazi, záver Hokejovej trilógie Dmitry Glukhovsky a Stanovište 2, postapokalyptický román Beata Balogová o svojej kronike dediny a rodiny Kornélie historická romanca Lisy Kleypasovej Diabol v prestrojení Sezóna zemolezu o starobylom sídle a rodinných tajomstvách Neuveriteľné príbehy z futbalových majstrovstiev sveta Svet podľa fyziky od kvantového fyzika a autora bestsellerov nové vydanie hitu Veľká panda a malý drak detská ilustrovaná knižka Tajomné jazero Tajomstvá slávnych výrokov pre deti a mladých Harry Potter a Fénixov rád - ilustrované vydanie (Jim Kay)  

CD Available at: http://borealnight.com/zdenka.html Zdenka is an eclectic conflux of musical styles that will excite and challenge you with influences as varied as King Crimson, McCoy Tyner, Brian May, Tony Williams, Karlheinz Stockhausen, the Beatles, John Mayall, Weather Report, John Coltrane, Steely Dan and Todd Rundgren. The music encompasses biting social satire, spiritual yearning, and explorations of love, desire and longing while featuring improvisations that range from rock, funk and jazz to the experimental. 

Zdenko Badovinac, nekdanjo dolgoletno ravnateljico Moderne galerije v Ljubljani, so na začetku leta izbrali za novo ravnateljico Muzeja sodobne umetnosti v Zagrebu. Položaj je prevzela v začetku marca s programom, ki ga je upravni svet Muzeja opisal kot visoko strokovnega, ambicioznega in hkrati realističnega. Badovinčeva se je takoj po prihodu v Zagreb odločila, da mora obuditi bogato zbirko Muzeja sodobne umetnosti, ki dve leti ni bila razstavljena. Napoveduje tudi razstave mednarodno znanih in uspešnih hrvaških sodobnih avtorjev, ki doslej niso razstavljali v MSU. Pričakovanja so velika, o svoji viziji zagrebškega Muzeja sodobe umetnosti in umetniškem povezovanju Slovenije in Hrvaške pa je Zdenka Badovinac več povedala v pogovoru z našo zagrebško dopisnico Tanjo Borčić Bernard. Foto: Žiga Živulovič jr. BOBO

This week, please join author Zdenka Pausova and Associate Editor Svati Shah as they discuss the article "Circulating Metabolome and White Matter Hyperintensities in Women and Men." Dr. Carolyn Lam: Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. We're your cohosts. I'm Dr. Carolyn Lam, Associate Editor from the National Heart Center and Duke National University of Singapore. Dr. Greg Hundley: And I'm Dr. Greg Hundley, Associate Editor, Director of the Pauley Heart Center at VCU Health in Richmond, Virginia. Dr. Carolyn Lam: Greg, have you ever wondered what white matter hyperintensities in a brain are made of? Well, guess what? The feature discussion is going to give us a little clue. Believe it or not from the circulating metabolome, interesting, huh? Well, I'm going to keep you in suspense, as we first discuss other papers in the issue. And I want to go first, may I? Dr. Greg Hundley: Absolutely, but let's all grab a cup of coffee. Dr. Carolyn Lam: All right. You got yours. And here goes. This first paper reviews the results of endovascular aneurysm repair in patients from the Japanese Committee for Stent Graft Management registry, to determine the significance of persistent type II endoleak and the risk of late adverse events, including aneurysm sac enlargement. Dr. Greg Hundley: Ah, Carolyn, a very clinically relevant question. So what did this study show? Dr. Carolyn Lam: Of more than 17,000 patients who underwent endovascular aneurysm repair for abdominal aortic aneurysm from 2006 to 2015, 29% had persistent type II endoleak. The cumulative incidence rates of abdominal aortic aneurysm related mortality, rupture, sac enlargement, and reintervention were higher in patients with persistent type II endoleak. Specifically, the cumulative incidence rates of rupture and abdominal aortic aneurysm related mortality increased to 2% at 10 year follow up, which is dissimilar to the previously reported frequency of only about 1%. Cox regression analysis revealed older age, female sex, proximal neck diameter, and chronic kidney disease as independent, positive correlates of sac enlargement. Dr. Carolyn Lam: So these wonderful results are from Dr. Hitoshi Matsuda and colleagues from the National Cerebral and Cardiovascular Center in Osaka Japan, and really suggests that persistent type II endoleaks are not always benign. Dr. Greg Hundley: Beautiful summary, Carolyn. Well, my paper comes from the world of pre-clinical science. And Carolyn, in most eukaryotic cells, the mitochondrial DNA is uniparenterally transmitted and present in multiple copies derived from the clonal expansion of maternally inherited mitochondrial DNA. All copies are therefore, nearly identical or, as we would call homoplasmic. Dr. Greg Hundley: Now Carolyn, the presence of more than one mitochondrial DNA variant in the same cytoplasm can arise naturally or as a result from new medical technologies aimed at preventing mitochondrial genetic diseases and improving fertility. The latter is called divergent non-pathological mitochondrial DNA heteroplasmy, or DNPH. Dr. Greg Hundley: Now Carolyn, these investigators led by Professor Jose Enriquez from the Centro Nacional de Investigaciones Cardiovasculares hypothesized that DNPH is maladaptive and usually prevented by the cell. Dr. Carolyn Lam: Wow, that's really interesting, investigations from the world of preclinical science. What did the investigators find? Dr. Greg Hundley: Right, Carolyn. So, the investigative team engineered and characterized divergent non-pathological mitochondrial DNA heteroplasmy, or DNPH, as we've talked about before, mice throughout their lifespan. The authors found that DNPH impair mitochondrial function with profound consequences in critical tissues that did not resolve heteroplasmy, particularly within cardiac and skeletal muscle. Progressive metabolic stress in these tissues led to severe pathology results, including pulmonary hypertension and heart failure, skeletal muscle wasting, frailty, and premature death. And finally, Carolyn, symptom severity was strongly modulated by the nuclear context. Dr. Greg Hundley: So in conclusion, Carolyn, these findings suggest that medical interventions that could generate divergent non-pathological mitochondrial DNA heteroplasmy, or DNPH, so to address potential incompatibility between donor and recipient mitochondrial DNA. Dr. Carolyn Lam: Oh wow. That is fascinating. Well guess what? My next paper is also about mitochondria, but this time looking at the role of the mitochondrial calcium uniporter. So we know that calcium is a key regulator of energy metabolism and impaired calcium homostasis damages mitochondria, resulting in cardiomyocyte death, pathological hypertrophy, and heart failure. Dr. Carolyn Lam: This study by Dr. Wang from University of Washington and colleagues investigated the regulation and the role of the mitochondrial calcium uniporter in chronic stress induced pathological cardiac remodeling. In a series of elegant experiments in the mitochondrial calcium uniporter knockout or transgenic mice infused with isoproteronol, the authors found that the mitochondrial calcium uniporter is up regulated in the stressed heart to orchestrate mitochondria sarcoplasmic reticulum, and cytosolic calcium handling, preventing cytosolic calcium overload induced cardiomyocyte death. Dr. Carolyn Lam: Lack of mitochondrial calcium uniporter mediated mitochondrial calcium uptake is detrimental. Whereas, transgenic over expression is beneficial to the heart during chronic beta adrenergic stimulation. The nuclear translocation of calcium/ calmodulin kinase II delta beta via calcineurin mediated dephosphorylation of serine 332 activates CAMP response element binding protein to promote mitochondrial calcium uniporter gene expression in adult cardiomyocytes. Dr. Greg Hundley: Well, Carolyn, what's the take home here? What are the clinical implications? Dr. Carolyn Lam: Ah, thought you might ask. Well, this study indicates that enhancing mitochondrial calcium uptake could be a new approach to prevent chronic beta adrenergic stimulation induced heart remodeling. Targeting this cam kinase two delta beta KREB mitochondrial calcium uniporter pathway could be a therapeutic option for pathologic cardiac remodeling associated with chronic adrenergic stress. Dr. Greg Hundley: Excellent description, Carolyn, and thank you for walking us through that wonderful paper. Well, we've got some other papers in the issue and from the mail bag, Professor Lusis has a Research Letter entitled Identification of DNA Damage Repair Enzyme, ASK II as Causal for Heart Failure with Preserved Ejection Fraction. And Carolyn there's a cardiovascular case series from Professor Barrett entitled, “The Unrepairable Infant Mitral Valve, an Unexpected Case of Decompensated Heart Failure.” Dr. Carolyn Lam: Interesting. There's an exchange of letters between Doctors Matrougui and Wang regarding the article, “Integrated Stress Response Couples Mitochondrial Protein Translation with Oxidative Stress Control” and a Perspective piece by Dr. Fatkin on “Fishing for Links between Omega-3 Fatty Acids and Atrial Fibrillation.” Wow. Super cool. Greg, let's go on now to a feature discussion, shall we? Dr. Greg Hundley: You bet. Dr. Carolyn Lam: For our feature discussion today, we are talking about white matter hyperintensities. Now that's the most common brain imaging marker of small vessel disease. That may be known, but there's a lot more to it. For example, what are they made of? Well, you're going to so enjoy today's feature paper, and I'm so proud to have the corresponding author with us, Dr. Zdenka Pausova from Hospital for Sick Kids in Toronto, Canada, as well as our associate editor, Dr. Svati Shah from Duke University. So welcome ladies. And Zdenka, if I could start with, could you explain the rationale for your study and what you did?   Dr. Zdenka Pausova: Yeah. Thank you. Thank you for having me. Well, we were thinking that it is important to know what the metabolic variables that associate with white matter hyperintensities might be, simply because we know that there are other studies that have shown that whatever circulates in blood is in some way related to brain health. For example, different lipids associated with Alzheimer Disease, cognitive functioning and with structural properties of the brain. So we were wondering what the metabolics that are associated with white matter hyperintensities might be, simply because we would like to know a little bit more about the pathogenesis of the disease, because that's what metabolomic profiling can provide. And also if one can identify biomarkers that potentially could be used in the clinical setting. Dr. Carolyn Lam: Wow. Thank you. And Zdenka, this may be a very basic question, but we hear a lot about the metabolome and sometimes it's not very clear what metabolome profiling actually is. And could you just say a little bit about the technique and your study population and then your findings? Thanks. Dr. Zdenka Pausova: Yes. Sure. So we actually studied over 9,000 individuals from eight different population based studies and all of those individuals had metabolomic assays done with two main platforms. It's mass spectrometry and nuclear magnetic spectroscopy. Mostly these platforms are actually commercially available and altogether across all platforms, there were over 2,200 different metabolites. And from those we could study about 1200 that we had at least in two populations. And what the metabolites are, these are different metabolites of lipids, sugar, proteins, amino acids that people put on those platforms or that designers put on the platforms, in order to test some of their hypotheses, that they were actually these metabolites of interest for different sorts of diseases, including cardiovascular and cerebrovascular disease. Dr. Carolyn Lam: Wow. So this is really large scale, massive, big data, if I may, and if I'm not wrong, it's the first large scale study to identify circulating metabolomic measures associated with white matter hyperintensities. So could you please summarize the main findings? Dr. Zdenka Pausova: Well, overall we actually found that there were 416 metabolites that were nominally associated with white matter hyperintensities, but as it is in epidemiology, you have to correct for multiple comparisons. So when we did DR correction, there were only 30 variables associated with white matter hyperintensities. And when we wanted to check whether those associations are independent of the risk factors for white matter hyperintensities, such as hypertension, type two diabetes, smoking, obesity, we actually ended up with seven markers, seven metabolites that were significantly associated in the fully adjust model. Dr. Zdenka Pausova: And the main one was actually a derivative of amino acid hydroxyphenol that probably is a marker of ischemia in the brain. And what actually I am coming to is, and one of the main findings was, that many of those metabolites were associated with white matter hyperintensities in a sex specific manner. That is that they were detected in the pool sample, but essentially the signal came from only one of the sexes. And so this one that was the most significant was detected only in males essentially, and not really in females. Dr. Zdenka Pausova: And that I think is an interesting, one of the most interesting findings that we can expect that there are really sex specific pathways, biochemical pathways, that accompany white matter hyperintensities. Dr. Carolyn Lam: Wow. Zdenka, thank you so much. I have to bring Svati in right now to share some perspective, Svati, especially to put these findings into context, please. Dr. Svati Shah: Yes. Dr. Pausova, really wonderful paper. This is an incredible study, if you think about it. The largest scale study that really is trying to understand metabolic by biomarkers, but the biomarkers actually tell us about the potential biology of what's going on with these white matter hyperintensities. We know that these hyperintensities in the brain are associated with increased risk of stroke, increased risk of cognitive decline, but we don't really understand stand what the risk factors are. There's been some studies suggesting that there's genetic risk factors, but this is really the first large scale study to say, "Hey, what's in the blood that we can measure?" And just to be clear, these technologies are measuring these biomarkers that are very, very, very low levels in the blood, really granular snapshot of what's going on with the human being. Dr. Svati Shah: And by looking at these blood markers that the authors were able to find biomarkers that are associated with these brain abnormalities, but really highlighting some of the important biology as Dr. Pausova started to talk about. So I think what it gets us to is we get to have our cake and eat it too. We get to learn about biomarkers that might have clinical utility, but we also have discovered, they've discovered new biology that could lead to new therapies, for example, and a better understanding of the mechanisms of why some people develop these hyperintensities as they age. And some people do not. Dr. Carolyn Lam: Wow, Svati, you put that so eloquently and just to put it out there for everyone, that significant metabolite hydroxyphenol pyruvate explain 14% of the variants of white matter hyperintensity volumes in males. Whereas, the proportion of variants explained by hypertension is only 1% or type two diabetes is only 1 to 3%, or smoking is even less than 0.1%. So this is, as you said, Svati, it's a significant discovery as well. Zdenka, though, how do we apply this clinically? Dr. Zdenka Pausova: Well, it could be a marker that is measured in circulation and it is a marker that can be measured in blood and can indicate early stages of white matter hyperintensities. But I think before we get there, it would be of high value to actually carry out some longitudinal studies, because it would be really interesting to know if it is an early marker before the white matter hyperintensities extent is enlarged. And so that would one thing. But other than that, I think if that would be the case, we can just measure it in blood and see how predictable it is. Dr. Carolyn Lam: Can I ask what about the women? Did anything predict it in women? Dr. Zdenka Pausova: That's a good question. There was only actually one variable. To our surprise, only one variable that was significantly associated with white matter hyperintensities in women. And it is really surprising because the sample size was the same. The extent, the volume of white matter hyperintensities was quite similar. They were of similar age, similar adiposity. So there were no huge differences, yet we could not actually detect too many metabolized associated with white matter hyperintensities in women. Really surprising. And I don't have a good answer for it now. Dr. Carolyn Lam: Wow. Thank you. Svati, did you have further thoughts on the clinical applications and implications of these tremendous data? Dr. Svati Shah: Yeah. I think the ability to have a biomarker as Dr. Pausova nicely articulated that would potentially prevent people from having to get an MRI. And we would be able to identify people hopefully at an earlier stage in the process. In this lovely study, they were looking at biomarkers in people who already had the hyperintensities. I think the next step as Dr. Pausova outlined to be able to identify whether these predict high risk people who will develop them in the future and then try to target therapies. A potential advance in precision medicine in the neurologic space, that we could use this biomarker to say, "You need this particular medication." Dr. Svati Shah: Some of the biomarkers that Dr. Pausova's group discovered were actually just cholesterol measures. So maybe we need to be instituting more aggressive cholesterol therapies in these patients who are at high risk. I'm not saying we can do that yet, but these provocative results suggest that this could lead to a more personalized approach to high risk individuals who may have consequences and develop these white matter hyperintensities. Dr. Carolyn Lam: And Zdenka, did you have anything to add to that? Dr. Zdenka Pausova: Perhaps one interesting aspect of the study that I actually was nicely surprised at the end of the study that the markers, one could the different lipids or the different derivatives of amino acids, the literature provided actually a possible pathways, how those could be involved in the development of white matter hyperintensities. Some of them actually, we could possibly link to impairment of myelination of a neuronal axons, or actually the axons themselves could be the metabolized could reflect damage of those axons.     Dr. Zdenka Pausova: And also, one suspicious pathway or one pathway that is suspected to be big part of the development of white matter hyperintensities is the disruption of blood brain barrier and some of the markers could be actually linked to that vascular dysfunction. Dr. Carolyn Lam: Aw, that's wonderful. Thank you so much, Zdenka, for publishing this beautiful work with us in Circulation. And thank you, Svati, for taking this paper through and inviting this beautiful editorial. In fact, it quite summarizes our discussion. It's entitled, What Turns White Matter White? Metabolic Clues to the Origin of Age-Related White Matter Hyperintensities and it's by Dr. Eric Smith from University of Calgary and I invite everyone to read this. Dr. Carolyn Lam: So thank you once again for joining us today on Circulation on the Run. From Greg and I, it's been wonderful having you. Don't forget to join us again next week. Dr. Greg Hundley: This program is copyright of the American Heart Association 2022. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more, please visit ahajournals.org.

Young adults entering the workforce experience many natural stressors. Add in a pandemic, and our fast-paced digital culture, it is understandable that many young people are facing a variety of mental health issues. Today we are joined by Zdenka Goralikova who is a Gestalt trained psychotherapist who works with young adults to support them during life transitions and reduce the anxiety that many of them are facing. Zdenka shares valuable insight that will not only support our young adult audience but also those who have a young person in their life. She provides many useful tips for productivity, like building your own calendar, starting your day with the task you are avoiding, and taking the breaks to regain focus. We also talk about the importance of being present, serving others, and how that supports your mental health.  Although our conversation was geared towards young professionals, the concepts apply to all adults who are wanting to level up their mental health, boost their self-confidence and walk in their power to self-heal.    Topics Discussed: Practical tips to regain focus during the workday Strengthening self-esteem and inner confidence Mentoring ourselves and being intentional with our self-talk   Connect with Zdenka : https://thepresenttherapy.squarespace.com/ --   SUBSCRIBE: iTunes: https://podcasts.apple.com/us/podcast/self-heal-with-dr-irene/id1561226627 Spotify: https://open.spotify.com/show/1pxldTJY5MZmneyz8IpSvm Youtube: https://www.youtube.com/channel/UCFTN-EU3umbz_0d0GFwk_Bw Stitcher: https://www.stitcher.com/show/selfheal-with-dr-irene TuneIn: https://tunein.com/podcasts/Health--Wellness-Podcasts/Self-Heal-(with-Dr-Irene)-p1421793/ Google Podcasts: https://podcasts.google.com/feed/aHR0cDovL3NlbGZoZWFsaW5nLm1pbmRzaGFyZWNvbGxhYm9yYXRpdmUubGlic3lucHJvLmNvbS9yc3M Deezer: https://www.deezer.com/show/2461592   Connect with us! Website: https://drirenecop.com/ LinkedIn: https://www.linkedin.com/in/drirenecop/ Facebook: https://www.facebook.com/drirene.health180/ Instagram: https://www.instagram.com/dr.irenec/?hl=en Youtube: https://www.youtube.com/channel/UCFTN-EU3umbz_0d0GFwk_Bw  

Jar a jeseň je na očistu tela ideálne obdobie, prečo je to tak? Ako by sme si mali v tomto období prispôsobiť jedálničiek a ako vplýva jedlo na naše emócie a prežívanie odpovie Zdenka Havettová. Absolvovala štúdium výživy v Nemecku, Holistickú školu a školu Tradičnej čínskej medicíny v Brne. V priebehu štúdia založila projekt Ide o Tvoje zdravie, ktorý je zameraný na podporu zdravia bežne dostupnými potravinami. Fascinovalo ju, že podľa Číňanov neexistuje jasná hranica medzi liekom a jedlom a väčšina chorôb môže byť zmiernená či vyliečená aj vďaka vhodne zvolenej strave.  O výživu sa začala zaujímať po ťažkých alergických záchvatoch, z ktorých sa dostala a dnes pomáha na ceste za zdravím ďalším ľuďom.

Hosty devátého dílu podcastu Taste of Prague česky jsou Zdenka a Martin Záhumenští, kteří provozují malou agenturu, jež zprostředkovává pobyty a zážitky v Toskánsku. Bavíme se o tom, jak budují vztahy s místními farmáři a vinaři, zda by bylo možné stejnou agenturu provozovat i v Česku nebo na Slovensku a co pro ně znamená skvělá hospitality.