Podcasts about aprea

Oren Gilad, President and CEO of Aprea Therapeutics, focused on the DNA damage response pathway, specifically targeting the ATR protein. ATR is a master regulator of DNA replication and is hyperactive in cancer cells, making it a potential Achilles heel for cancer therapy. By inhibiting ATR, cancer cells can be selectively targeted, while normal cells can tolerate lower levels of ATR activity. Synthetic lethality is applied when two genetic mutations are combined, leading to cell death, specifically in cancer cells. Aprea is conducting clinical trials for their targeted treatments, focusing on solid tumors with defined genetic mutations. Oren explains, "DDR, the DNA damage response pathway, is the broader terminology for the regulation of DNA synthesis. In order for cancer to grow, cells have to duplicate. In order for them to duplicate, they have to replicate their DNA. So what happens is that cancer cells get into this DNA replication phase very early and prematurely, causing a single-strand DNA to be exposed which then activates the ATR pathway, where in normal cells, this pathway is very tightly regulated. The normal cell is not going to enter this phase and start DNA replication before the environment is ready because it's a very fragile phase of the cell cycle." "Double-strand DNA is a very stable molecule. It is found in mummies, it survives heat, and it survives freezing. When a double-strand DNA molecule is opened, the exposed single-strand DNA can easily break. That's where ATR comes into play, it protects and responds to single-strand formation. A cancer cell is hyper-sensitive to ATR inhibition, which we identify as the Achilles heel of cancer. Our work showed that normal cells can live with a reduced level of the ATR activity, so it makes it a good target for cancer therapy." #ApreaTherapeutics #CancerTreatment #TargetedTherapy #Oncology #Cancer #SyntheticLethality #DNADamageResponsePathway aprea.com Download the transcript here

Oren Gilad, President and CEO of Aprea Therapeutics, focused on the DNA damage response pathway, specifically targeting the ATR protein. ATR is a master regulator of DNA replication and is hyperactive in cancer cells, making it a potential Achilles heel for cancer therapy. By inhibiting ATR, cancer cells can be selectively targeted, while normal cells can tolerate lower levels of ATR activity. Synthetic lethality is applied when two genetic mutations are combined, leading to cell death, specifically in cancer cells. Aprea is conducting clinical trials for their targeted treatments, focusing on solid tumors with defined genetic mutations. Oren explains, "DDR, the DNA damage response pathway, is the broader terminology for the regulation of DNA synthesis. In order for cancer to grow, cells have to duplicate. In order for them to duplicate, they have to replicate their DNA. So what happens is that cancer cells get into this DNA replication phase very early and prematurely, causing a single-strand DNA to be exposed which then activates the ATR pathway, where in normal cells, this pathway is very tightly regulated. The normal cell is not going to enter this phase and start DNA replication before the environment is ready because it's a very fragile phase of the cell cycle." "Double-strand DNA is a very stable molecule. It is found in mummies, it survives heat, and it survives freezing. When a double-strand DNA molecule is opened, the exposed single-strand DNA can easily break. That's where ATR comes into play, it protects and responds to single-strand formation. A cancer cell is hyper-sensitive to ATR inhibition, which we identify as the Achilles heel of cancer. Our work showed that normal cells can live with a reduced level of the ATR activity, so it makes it a good target for cancer therapy." #ApreaTherapeutics #CancerTreatment #TargetedTherapy #Oncology #Cancer #SyntheticLethality #DNADamageResponsePathway aprea.com Listen to the podcast here

Questa settimana nuovo podcast di Propaganda Live: Space Pasta, il monologo di Valerio Aprea.

In this episode of The Workplace podcast, employment law expert Matthew Roberts and Chris Micheli, partner with Aprea & Micheli, Inc., join up again to give a second update on remaining key labor and employment-related bills that await the Governor's pen. The proposals discussed include a bill setting a workplace violence standard, SB 553 (Cortese; D-San Jose); a WARN Act expansion, AB 1356 (Haney D-San Francisco);  a notice requirement to return remote employees to the workplace, SB 731 (Ashby; D-Sacramento); a CalChamber-opposed bill setting an onerous return to work mandate, SB 723 (Durazo; D-Los Angeles); and a CalChamber-opposed bill establishing a 90-day retaliation presumption, SB 497 (Smallwood-Cuevas; D-Los Angeles).

In this episode of The Workplace podcast, employment law expert Matthew Roberts and Chris Micheli, adjunct professor at the University of the Pacific, McGeorge School of Law and a partner with Aprea & Micheli, Inc., give an update on important labor and employment-related bills that passed the California Legislature last week, including bills on discrimination in the workplace (SB 403 (Wahab; D-Hayward), CalChamber job killer bill AB 524 (Wicks; D-Oakland), CalChamber-opposed bill AB 2188 (Quirk; D-Hayward), and SB 700 (Bradford; D-Gardena)); expansion of paid sick leave (CalChamber job killer bill SB 616 (Gonzalez; D-Long Beach)); and reproductive-related bereavement leave (CalChamber “Oppose Unless Amended” bill SB 848 (Rubio; D-Baldwin Park)).

All'interno del 52 di Corso Venezia nel giardino della Fondazione Luigi Rovati apre il dehors del Caffè Bistrot Andrea Aprea. Uno spazio suggestivo sotto il cielo di Milano dove l'atmosfera estetica tipica delle corti segrete meneghine incontra una proposta gastronomica delicata che lavora sulla riscoperta di piatti della tradizione regionale italiana. Il dehors del Caffè Bistrot Andrea Aprea si pone come il perfetto rifugio en plein air dalla città dove respirare un'atmosfera senza tempo e una cucina vocata all'eccellenza, all'interno di una cornice perfetta per intendere il rapporto tra tempo e cibo.

Al Caffè Bistrot Andrea Aprea in Corso Venezia 52, presso la Fondazione Luigi Rovati, va in scena la relazione tra l'arte della mixology e piccoli piaceri gastronomici. Lo chef Andrea Aprea interpreta con la propria storia uno dei capisaldi della cultura gastronomica milanese, all'interno di una cornice perfetta per intendere il rapporto tra tempo, cocktail e cibo. Al centro, il sistema di relazioni che l'aperitivo porta con sé e tutti quei significati di una cultura che lo ha reso un momento in più, capace di dilatarsi nell'orario, nelle proposte gastronomiche e nelle funzioni.La CartaL'esperienza della mixology è affidata a Alejandro Pellejero, vincitore per due volte del campionato Pan-Americano di Barman e riconosciuto nel 2017 e 2018 tra Top 15 Best World Flairbartender, che ha pensato la carta cocktail a quattro mani con lo chef. A caratterizzare la proposta sono i cocktail “Contemporanei”, risultato di un'accurata ricerca di spirits e distillati base, che raccontano territori e tradizioni di differenti culture. Ogni drink rivede quegli archetipi classici alla luce della propria personale sensibilità e che esprimono il piacere della scoperta, il rapporto della natura, il viaggio creando inedite combinazioni di sapori per i palati più audaci.

Family-owned restaurants come with a unique set of challenges.. Rino and Teresa Aprea of Rino's in Boca and Ponte Vecchio in Brooklyn, are also former cast members of The Real Housewives of New Jersey's season six, and open up about the importance of a solid support system when running a family business. They join podcast host Jaclyn Beck for an open conversation about keeping perspective, leading by example and empowering others to thrive. Visit Rino's of Boca and Ponte Vecchio in BrooklynFollow along @tereseaapreaConnect with Jaclyn Beck on LinkedIn, follow along on Instagram @jaclynbeckconsulting and check out Jaclyn Beck Consulting for strategic advisory and/or executive coaching inquiries.

Questa settimana per l'ascolto in podcast abbiamo selezionato, dalla puntata di Propaganda Live di venerdì 10 marzo, il monologo di Valerio Aprea.

Il monologo di Valerio Aprea nella puntata di Propaganda Live di venerdì 11 novembre

Vi proponiamo l'ascolto del monologo di Valerio Aprea nella puntata di Propaganda Live di venerdì 21 ottobre

"Gli aumenti di prezzo non li fa Ota Viaggi perché non gestisce direttamente le strutture. Stiamo lavorando per cercare di mitigare gli aumenti e mantenere la qualità dei prodotti". Così Mario Aprea, cfo del tour operator, racconta ai microfoni di Gente di Viaggi il lavoro dei prossimi mesi per un'azienda che ha il suo core business nel prodotto estivo (Music credit: http://www.freesfx.co.uk)

Biennale di Viterbo Arte Contemporanea con “Il ritorno di Dalì” di e con Demian Antonio Aprea, accompagnato da Gabriele Fioritti, al violoncello.

Nuovi luoghi dell'esperienza gastronomica. Il 7 luglio apre al pubblico il nuovo Ristorante Andrea Aprea: dove gusto, memoria e tempo si incontrano.Posto all'ultimo piano della Fondazione Luigi Rovati - in un magnifico edificio storico che ospiterà il Museo d'Arte della Fondazione - il Ristorante raccoglie in una cornice estetica dalle proporzioni pure tutti i valori dell'esperienza gastronomica che Aprea ha definito in un percorso di ricerca ventennale.L'ambiente, progettato dall'architetto Flaviano Capriotti, è caratterizzato da uno spazio dal grande impatto scenografico, dove una sorprendente vetrata panoramica apre lo sguardo sul parco di Porta Venezia e sullo skyline della città.

Vi proponiamo l'ascolto del monologo di Mattia Torre "Guarda l'azione" letto da Valerio Aprea

Vi proponiamo l'ascolto del monologo sulla distopia di una guerra atomica di Valerio Aprea

Big Bands were on their way out when jazz musician Ron Aprea was ready to make his mark on the music scene.  However, that didn't deter the young saxophone player from embarking on a career in that genre.  Without a doubt the New York native had talent. His sax playing and instincts were top rate, and eventually his ability to arrange and write charts would grab the attention of his peers. So, with all that talent and a deep love for big band music, Aprea doggedly became a successful part of the final era of the great big bands.  Fittingly, his new autobiography is entitled ‘The Era I Almost Missed,' and, to borrow a phrase from Dr. Seuss, “Oh, the places he went!”…and the people he met. He has played major roles in performances with music legends such as Lionel Hampton, Louis Armstrong, Woody Herman, Tito Puente and even rocker John Lennon at the height of his post-Beatle popularity. In an interview with journalist and songwriter Robert Neil, Aprea talks about his career and how jazz seemed destined to be a part of his life. The book is available at his website, www.ronaprea.com 

Vi proponiamo l'ascolto del monologo di Valerio #Aprea: "Quelli come Te"

Dopo il successo di "Non ci resta che il crimine" sta finalmente per uscire l'atteso sequel "Ritorno al crimine". Di questo, dei suoi inizi da autore indipendente e di molto altro parleremo in questa nuova puntata!Buon ascolto!----"Ogni Maledetto Indipendente - La Finestra sul Cinema Indie"da un idea di Massimo Righetti & Vania AmitranoProdotto da Back to the Movies & MA6 StudioSigla: Joe CalabròMusiche: Joe Calabrò, Stefano SellanSponsor: GuitexGuitarsper info.e contatti: backtothemovies4@gmail.com

Clean Up Gaeta-Formia è un gruppo di ragazzi che vogliono fare la differenza sul nostro territorio organizzando raccolte rifiuti nelle spiagge per sensibilizzare a non sporcare, pulire e rispettare l'ambiente. Ne abbiamo parlato nell'ultima puntata di Generazione Umana insieme a Federica Aprea

Vi proponiamo l'ascolto del monologo di Valerio Aprea

Vi proponiamo l'ascolto del monolodo di Valerio Aprea con l'elenco di tutte, o quasi, le nuove espressioni social che nascono ogni giorno sui social, ma anche quelli di 80 anni fa

Vi proponiamo l'ascolto del monolodo di Valerio Aprea con l'elenco di tutte, o quasi, le nuove espressioni social che nascono ogni giorno sui social, ma anche quelli di 80 anni fa

#336: On this episode we are joined by our friends Betsy Parker and John Aprea. Betsy is a renowned pilates instructor, business owner & mother who operates out of Los Angeles. John Aprea is a an actor who you may recognize from roles including The Godfather Part 2, Full House as Uncle Jesse's Dad, and Bullitt with Steve McQueen. On today's episode we discuss how 9 marriages finally led to love, health, wellness, pilates, acting, and more.   To connect with Lauryn Evarts click HERE To connect with Michael Bosstick click HERE Read More on The Skinny Confidential HERE For Detailed Show Notes visit TSCPODCAST.COM To Call the Him & Her Hotline call: 1-833-SKINNYS (754-6697) This episode is brought to you by Beekeeper's Naturals Beekeeper’s Naturals is on a mission to reinvent your medicine with clean, effective products that actually work. Bee propolis delivers natural germ-fighting properties and antioxidants to defend and protect our bodies. It’s sustainably sourced and this Spray is made with just three simple ingredients. You’ll never find refined sugars, dyes, or dirty chemicals in these products. Ever. We've worked out an exclusive deal for Skinny Confidential listeners. Receive 15% off your first order. Go to www.BEEKEEPERSNATURALS.com/SKINNY or use code SKINNY at checkout to claim this deal.  This episode is brought to you by Wanu Water Wanu water (water + nutrients) is the first-to-market, best-selling nutrient-infused water packed with 10 essential vitamins including 24% of your daily fiber intake providing natural energy that boosts your metabolism, supports a healthy immune system and quenches your appetite while you hydrate. Visit www.Wanuwater.com/skinny and promo code SKINNY for 20% off all regular case orders This episode is brought to you by Phexxi Phexxi® (lactic acid, citric acid, and potassium bitartrate) Vaginal Gel 1.8%, 1%, 0.4% is a hormone-free, prescription birth control used only before sex. Phexxi works to maintain the vaginal pH level to prevent pregnancy and you only use it when you need it! Be sure to tell your healthcare provider if you have a recent history of 3 or more UTIs per year. Learn more, including all risks at Phexxi.com The episode is brought to you by AncestryHealth  Your inherited health risks don't have to stay unknown. Learn if you're at lower or higher risk for some commonly inherited conditions linked to breast cancer, colon cancer & heart disease, with AncestryHealth. Find out what your DNA says about genetic risk with AncestryHealth®. Head to Ancestry.com/SKINNY to get your AncestryHealth® kit today! Produced by Dear Media

Vi proponiamo l'ascolto del monologo "Amigdala" di Valerio Aprea a Propaganda Live

APREAポッドキャストにようこそ。今回は、森ビルの取締役副社長執行役員、森浩生氏をお迎えし、日本不動産研究所の企画部 副部長、山下誠之氏による、新春インタビューをお届けします。森副社長の人となりを伺いつつ、森ビルの都市づくりについて、その現状と展望、今後の抱負などについて語っていただきました。また、ポスト・コロナのニューノーマルへの時代に向けた課題なども伺いました。日本の働き方改革、業界の若い人々への貴重なアドバイスなども含まれております。

Quella mattina Cassandra (sua madre l'aveva chiamata così perché aveva una grande passione per la storia e la mitologia greca) si svegliò come sempre alle sette.Le piaceva alzarsi presto.Fin da quando era poco più che una bambina pensava che “il mattino avesse l'oro in bocca!”.Il volume è disponibile per il prestito presso la Biblioteca Lorenzo Lodi Roma.

Eighteen months ago, Sigrid Zialcita, CEO the Asia Pacific Real Estate Association, predicted on the pages of Institutional Real Estate Asia-Pacific that Asia’s REITs would have a banner century. We visit with the leader of APREA to get an update on that assessment, as well as to ask her what concerns her most about the Asia REIT business, and what makes her most optimistic about their continued progress. (12/2020)

In this episode Dr Aleks Marsh and Dr Alan Mullan welcome special guest, Dr Guiseppe Aprea who is an Official Veterinary Officer at the Experimental Zooprophylactic Institute of Abruzzo and Molise, Teramo in Italy. We discuss Bacteriophages and ask Giuseppe – what are bacteriophages? And why are these “good guys of the virus world” important for applications such as alternative to antibiotics or for gene therapy? Find out more about Giuseppe's research into food borne bacterial and viral pathogens and also how their Institute became involved in battling COVID-19 through the pandemic in Northern Italy. Website - http://www.izs.it/IZS/Engine/RAServePG.php/P/250010010603/L/0 LinkedIn – linkedin.com/in/giuseppe-aprea-7b869363

In this week's episode, I speak with Jennifer Aprea. Jennifer was an elementary school teacher for 12 years, currently serves at the Director of Family Engagement for The Arc of Tennessee, and offers an important perspective as the parent of a child with multiple disabilities. Her passion for education and families shines through, and I hope you enjoy our conversation as much as I did.

Na'ima Robert, Daniel Aprea & Christine Erickson join Bernardo Moya in the latest webinar series of Inspiring People, where speakers give their thoughts on persevering through the strange, chaotic times we find ourselves in.To find out about Bernardo’s latests projects get a free coaching lesson or download my book go to www.bernardo-moya.com For more information go to: www.thebestyou.co or to view the video recordings go to www.thestyou.online

George talks about his dating experience, hiking, law enforcement, and politics. 

"Serving" Teaching with Pastor Frank Aprea

OMN E042 | Get More Clients & Sell With Heart: Daniel Aprea is the Founder of Coachized, award-winning Speaker, Trainer, Coach and London-based Entrepreneur. After being a struggling life coach, becoming homeless and sleeping on three chessboards in his chess club, he spent the last 10 years of his life in the coaching and sales industry where he turned it around and developed his signature system which allowed him to sell multiple 7 figures without having to be manipulative or sales-y. He now focuses on helping coaches and heart-centred entrepreneurs get more clients and make an impact.   Don't forget to connect with me @TheJamieKeeling on Facebook & LinkedIn Let's work together to take your business to the next level - Business Accelerator Programmes: "Assisting Businesses Turning Over £500k + Struggling With Performance, Profitability & Failing Systems"  Please SHARE, SUBSCRIBE, & leave a REVIEW!  www.optimisemenow.com

Alfonso Cuaron per Roma, Rolando Ravello, Iaia Forte e Valerio Aprea, Ilaria Spada per Altri sguardi

Ascolta la lettura integrala di "Neve" letto da Valerio Aprea

Having played with some of the greats on the big band scene, saxophonist Ron Aprea has carved out a long and successful career as a jazz musician. He has also been part of rock and roll history as one of a small group of horn players to record with John Lennon on the former Beatle’s 1974 Walls and Bridges album. In this interview with Robert Neil, Aprea talks about his recent tribute album to Lennon and the Beatles as well as what it was like to record with Lennon (including a story about Lennon photocopying his face). Notably, Aprea’s album features a version of “Imagine,” where he is joined by trumpeter Steve Madaio, one of the other original musicians from the Walls and Bridges sessions. (More information about Aprea and his album can be found at RonAprea.com.) (The interview was produced and recorded at the O&F Studios, www.OandFStudios.com)

Valentina Aprea: La miglior prevenzione alla dispersione scolastica è lavorare by Lavoradio

Valentina Aprea, assessore al Lavoro della Regione Lombardia, illustra le best practice lombarde by Lavoradio

“LO S(tra)VOLGIMENTO DELLA PROFESSIONE FORENSE SENZA EQUO COMPENSO E SENZA NECESSITA’ DI ASSISTENZA TECNICA: QUALI PROSPETTIVE ? ”CONSIGLIO DELL’ORDINE DEGLI AVVOCATI DI NAPOLI - COMMISSIONE RESPONSABILITA’ CIVILE PRESSO IL COA DI NAPOLIEnte Biblioteca di Castel Capuano “Alfredo De Marsico”Napoli - Piazza E. De NicolaINDIRIZZI DI SALUTO:Avv. Armando Rossi- Presidente dell’Ordine degli Avvocati di NapoliAvv. Roberto Fiore - Presidente Ente Biblioteca di Castel Capuano “A. De Marsico”Avv. Edoardo di Natale - Coordinatore Commissione RCINTRODUCE E MODERA:Avv. Elena De Rosa - Commissione RCRELAZIONI:Prof. Avv. Francesco Sbordone - Ordinario di Istituzioni di Diritto Privato, DIPARTIMENTO di Giurisprudenza SecondaUniversità di NapoliProf. Avv. Salvatore Monticelli - Ordinario di Diritto Privato, DIPARTIMENTO di Economia e Commercio, Università di FoggiaProf. Avv. Angelo Scala - Ordinario di Diritto Processuale Civile, DIPARTIMENTO di Giurisprudenza, Università degli Studi diNapoli Federico IIINTERVENTI:Sono stati invitati alla Tavola Rotonda Tutti i Deputati ed i Senatori firmatari e co-firmatari deiDL. (C. 3854 - 3745, S. 2249 – 2281) in materia di Equo Compenso e i Presidenti degli Ordini Forensi del Distretto diCorte di Appello di NapoliComitato organizzatore: Avv. E. Di Natale, Avv. E. De Rosa, Avv. L. Canale, Avv. S. Esposito, Avv. R. Tortoriello, Avv. N. Mensitieri, Avv.F. Todisco, Avv. G. Fraticelli, Avv. A. Melillo, Avv. G. Crimaldi, Avv. O. Cataldi, Avv. M. La Duca, Avv. F. Errico, Avv. F. Muoio,Avv. G. Meo, Avv. P. Gargano, Avv. R. Locantore, Avv. N. De Angelis, Avv. N. Corcioni, Avv. R. Raio, Avv. F. D’Ambrogio, Avv. R. Giovenedi Girasole, Avv. A. Serra, Avv. I. Imparato, Avv. A. Panico, Avv. M. Cianci, Avv. G. Campolo, Avv. C. Foreste, Avv. G. Ferone, Avv.G.Iacomino, Avv. A. Valentino, Avv. L. Aprea.Parteciperanno all’evento le ss. Associazioni Forensi:AIGA NAPOLI; AIGA NAPOLI NORD; ALPHA LAWYERS; ASSOCIAZIONE FORENSE “G.PORZIO” –PORTICI-ERCOLANO;OFFICINA FORENSE; SINDACATO FORENSE DI NAPOLI-ANF; UNIONE GIOVANI CIVILISTI; ASSOCIAZIONE ENRICO DENICOLAQuesta trasmissione è possibile grazie alla sponsorizzazione di SISTEMI s.p.a. - visita il sito www.sistemiamolitalia.it

Rabbit of No Material Character by Jonathan Aprea

San Fransisco has been to the Superbowl, the World Series and the NBA playoffs in the last year or so, but nothing more exciting has happened than the advent of Mobius Trio, a new and exciting group of young Bay Area guitarists out to beat new music into the minds of the many. Matthew Holmes Linder serves as their ambassador to Big Diaper Bret's winter estate. 

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La pubblicazione delle graduatorie dei presidi in Lombardia mette fine a due anni di ricorsi e controricorsi, ma gli ex promossi, ora bocciati, non ci stanno - La Via d'acqua di expo non passerà più dai parchi milanesi, intervista a Gianni Confalonieri e microfono aperto.

La pubblicazione delle graduatorie dei presidi in Lombardia mette fine a due anni di ricorsi e controricorsi, ma gli ex promossi, ora bocciati, non ci stanno - La Via d'acqua di expo non passerà più dai parchi milanesi, intervista a Gianni Confalonieri e microfono aperto.