Podcasts about youtrients

Show notes: (1:41) Kashif's journey and discovery of genomics (10:29) Supporting mitochondrial health (12:20) APOE gene and Alzheimer's risk (18:01) Importance of taking action based on genetic insights (24:15) Methylation and holistic DNA testing approach (29:55) The role of DNA in understanding health outcomes (34:05) Common genetic issues, particularly in female hormone health (36:15) The DNA Company's approach to interpreting results (40:42) Future possibilities with gene editing technologies (44:22) Outro Who is Kashif Khan?   Kashif Khan is an entrepreneur and investor who has built, run, and scaled businesses across a range of industries. He is the co-founder of The DNA Company, an innovative provider of functional genomics solutions for personalized and preventative health and wellness.   Kashif is also the co-founder of Youtrients, a company providing personalized supplement formulations based on unique DNA analysis. Connect with Kashif: Websites: https://thednacompany.com/                   https://kashkhanofficial.com/ LinkedIn: https://www.linkedin.com/in/mrkashkhan IG: https://www.instagram.com/kashkhanofficial/?hl=en Links and Resources: Peak Performance Life Peak Performance on Facebook Peak Performance on Instagram

The host of “The Thinking Health Podcast” in this episode is Chris Irvin, an expert in the health and wellness industry. The guest for this episode is Kashif Khan, the CEO and Founder of “The DNA Company” and “Youtrients.” Kashif Khan is an entrepreneur and investor who has built, run, and scaled businesses across various industries over the last 20 years. He has made millions and experienced losses, but his experiences have prepared him for his current role as a trailblazer in personalized and preventative health and wellness. He co-founded The DNA Company, an innovative provider of functional genomics solutions, and Youtrients, a company providing personalized supplement formulations based on unique DNA analysis. Kashif Khan's qualifications and achievements include being a Certified Epigenetic Coach and having a Doctorate in Natural Medicine. He has been featured in various media outlets, including NBC, ABC, FOX, and The Huffington Post. Kashif Khan is also a sought-after speaker and has delivered keynote speeches at several international genetics and personalized medicine conferences. The podcast has invited him as a guest to provide valuable insights into personalized medicine through genomic interpretation and share his experiences as a successful entrepreneur in the industry. In this episode of “The Thinking Health Podcast,” listeners will have the opportunity to delve into the fascinating world of personalized medicine through genomic interpretation with Kashif Khan, the CEO and founder of The DNA Company. Host Chris Ervin and Kashif Khan explore a range of topics, including the connection between aging and mitochondrial function, the impact of modern environmental factors on our genetic capacity to detoxify, and the link between autoimmunity and gut health. Listeners will gain insights into The DNA Company's innovative approach to personalized medicine and DNA testing and an interesting success story about DNA testing and custom supplements. Don't miss out on discovering strategies for optimizing health and nutrition and learning to live harmoniously with your DNA. Sneak Preview: What to Expect in this Episode 00:00:00 to 00:03:07 Introduction 00:03:07 to 00:06:35 What led Kashif Khan to found The DNA Company and pursue personalized medicine? 00:06:35 to 00:09:36 What causes the average American to be diagnosed with their first chronic disease at 55 and accumulate two conditions by age 65? 00:09:36 to 00:13:10 What is the association between the decline in mitochondrial function and aging, and how can lifestyle choices help preserve it? 00:13:10 to 00:18:22 How can genetic testing provide actionable insights for individuals in making informed lifestyle choices to optimize their health? 00:18:22 to 00:21:52 How can understanding the function of genes as part of an interconnected system help improve overall health? 00:21:52 to 00:27:00 How is autoimmunity connected to gut health, and what role does genetics play in gut detoxification? 00:27:00 to 00:37:00 How has the modern environment affected our genetic capacity to detoxify, and what lifestyle changes can be made to support detoxification deficiency? 00:37:00 to 00:40:26 Has uncovering his DNA altered how Kashif collaborates with others, and how has this affected his team dynamics? 00:40:26 to 00:45:12 How has using DNA to pinpoint strengths and weaknesses impacted Kashif's company culture and extended to clinical and family dynamics? 00:45:12 to 00:52:47 What is the DNA testing process used by The DNA Company, and what information do they offer clients in their user-friendly reports? 00:52:47 to 00:56:02 What recommendations are provided with DNA test results from The DNA Company, and how are the results delivered to customers? 00:56:02 to 01:01:42 What is Kashif's opinion on the adaptability of genetic traits, and how can people manage or alter them? 01:01:42 to 01:08:11 What is an interesting success story from Kashif's company regarding DNA testing and custom supplements? 01:08:11 to 01:13:21 Where can people learn more about Kashif and The DNA Company, and how can they collaborate?  

There's a lot of talk about DNA testing, but how effective and accurate is it really in addressing health concerns like chronic poor sleep? This week Dr. Porter sits down with Harris Khan from The DNA Company to discuss how using intelligent DNA testing can help build a precision-based approach to addressing chronic conditions, including poor sleep, by focusing on outcomes rather than genes and building in behavioral change to initiate sustainable, long-term health and wellness optimization. Harris holds a Bachelor of Science in Honors Biomedical Sciences from the University of Waterloo. After completing his undergraduate studies, he pursued post-graduate studies in Pharmaceutical Research and Development, before gaining employment at Apotex, Canada's largest generic pharmaceutical company, in the Formulations Development department. Harris was a key member of the team that would test initial formulations for billion-dollar drugs in their infancy stages. He left Apotex to co-found Youtrients, now The DNA Company, where he established an ISO-7, GMP-compliant nutraceutical compounding facility. As The Director of Product Development for The DNA Company, Harris oversees the entire lifecycle of The DNA Company's suite of products and services. In collaboration with industry experts and clinicians, he spearheaded the development of The DNA Company's proprietary genomic algorithms based on metanalyses of thousands of genomic data points. He is a co-author of patents in the field of functional genomics and speaks on behalf of The DNA Company at events and conferences worldwide. One of Harris's favorite health hacks includes eating dates during periods of heavy mental or physical activity. Says Harris: “They're an incredible source of nutrients and improve water retention. There's a reason they grow in arid environments like desserts! Two to three dates in the morning can be nutritionally fulfilling and provide the necessary glucose your brain needs to function throughout the day.” What you'll learn: • Why most DNA tests are confusing • How choosing the right DNA test provider can help you solve your health problems • How genetics contribute to, but do not define, a person's potential • Strategies to optimize genetic variations • How behavioral changing solves the problem of what's next after DNA testing Check out the DNA Company Here: Web: www.thednacompany.com Social: @thednaco Special Offer: Thednacompany.com/sleepwell

Bryce Wylde BSc (hons), DHMHS is a leading health expert and clinician at VennMed in Toronto, co-founder of Youtrients and The DNA Co.  Bryce is also the founder of mymmunity, a best-selling author, previous host of CTV's Wylde On Health, and regular guest health expert and medical advisor to the “The Doctor Oz” show.Connect with Bryce:Website | HereMymunnity | Here "Enter code EPOCH20 to save 20% until the end of March 2022"New Book - "Brainspanners" | HereInstagram |  HereConnect with EPOCH:Shop Our Grass Fed Whey Protein Isolate | HereA percentage of proceeds from sales will go to Youth Mental Health CanadaInstagram | @live.epochWebsite | www.yourepoch.com

Harris Khan holds a Bachelor's of Science in Honours Biomedical Sciences from the University of Waterloo. After completing his undergraduate studies, he pursued post graduate studies in Pharmaceutical Research and Development, before gaining employment at Apotex, Canada's largest generic pharmaceutical company, in the Formulations Development department. Harris was a key member of the team that would test initial formulations for billion-dollar drugs in their infancy stages. He left Apotex to co-found Youtrients, now The DNA Company, where he established an ISO-7,  GMP-compliant nutraceutical compounding facility. He currently serves as The Director of Product Development, where he oversees oversees the entire lifecycle of The DNA Company's suite of products and services. For information about ordering a test as a consumer head to www.TheDNACompany.com. If you are a provider looking to create a practitioner account, head to www.DNA.clinic.   Thanks so much for listening and you know I want to help you have a healthy business inside and out! If you have been trying to market and sell your services and things just aren't clicking for you, then we would like to help you have a MAJOR shift and feel completely confident in how you move people through a health journey.  I want to invite you to take advantage of a special FREE Health Program Discovery session where you will work together with one of our coaches to... Create an empowering vision for your health business success  Find hidden barriers that may be limiting your growth  Feel the confidence successful health providers embody in their business and grab some inspiration for yourself to have a highly converting, extraordinarily successful signature health program Head over to SarahTugender.com/workwithsarah to grab one of our limited spots.

We discussed a few things including Kashif's entrepreneurial journey, personalized medicine, functional genomics, longevity trends and the future of healthcare. Kashif is an author, speaker, visionary entrepreneur and investor based in Toronto who has built, run, and scaled numerous businesses across various industries. He is the founder and CEO of The DNA Company, a digital health company that uses precision medicine and digital therapeutics to develop genomics-based health management applications that offer patients genetic insights tailored to their unique biology. Kashif is also the co-founder and CEO of Youtrients, a company providing personalized supplement formulations based on unique DNA analysis. In his career, He has advised everyone from early-stage startups to numerous Fortune 500 clients including some of North America's biggest companies like Royal Bank of Canada and Cirque Du Soleil.

Get your unique DNA Report Here 9Exclusive Discounts): https://www.thednacompany.com/?utm_source=2371&utm_medium=affiliate&__ef_tid=3d9aba554dbc4532b6c2fd1db79fcd61 Prevent disease. Slow aging. Optimize performance. Every cellular process in your body is instructed by the 22,000 genes that make up your genetic code. Our nutrition, lifestyle and environment decisions impact our genetic function. Decode your genes so you can make the right choices. Stream this episode now to learn more about how you can hack your DNA and optimize your life. About Our Guest: Kashif's genes are an uncanny match for his personality and business acumen. He has a dizzying ability to multitask, and an unfathomable disregard for danger, all of which show up in his genetic profile. However, his genes also reveal a reduced ability to detoxify pollutants, fumes, environmental chemicals, and pesticides. Despite his steely executive function, Kashif is much more chemically sensitive than his colleagues. He recently experienced the effects of his reduced detoxification ability during the construction of Youtrients' state of the art facility. Visiting the construction site, while industrial floor sealants were still being applied, Kashif developed a severe eczema reaction within hours of exposure. Two weeks away from the facility, his eczema flare had all but disappeared. A second return to the contruction site brought his condition right back. His innate, inherited detoxification pathways could not handle this overload. Youtrients developed a personalized supplement for Kashif that included the correct dose of NAC, selenium, milk thistle, and alpha lipoic acid (ALA). These nutrients enhance his suboptimal detoxification pathway, enabling his body to deal with pollutants and chemicals, while reducing his risk of longterm illness.

Kashif Khan is an entrepreneur and investor who has built, run, and scaled businesses across a range of industries. He is the co-founder and Chief Executive Officer of The DNA Company, an innovative provider of functional genomics solutions for personalized and preventative health and wellness. Kashif is also the co-founder and CEO of Youtrients, a company providing personalized supplement formulations based on unique DNA analysis.

Dr. Mansoor Mohammed is the Founder and President of ManaGene which was acquired by The DNA Company and merged with Youtrients to launch one of Canada's most innovative lifestyle and functional genomics companies. Dr. Mohammed is widely regarded as a pioneer in medical genomics and has been the recipient of multiple academic and industry awards. He is the holder of several patents in the general fields of molecular diagnostics and genomics research. Discounts from The DNA Company for our listeners: Comprehensive Functional Genomics Profile | Female Hormone Profile | Male Hormone Profile | Infectious Disease and Response Profile | * At this crucial time in history, anyone — yes, anyone — can learn about and understand their genetically influenced outcomes to infectious diseases and precisely what they need to do to alter them. Whether you are trying to understand your body's unique genetic makeup, enhance your immune system, or anticipate how your body responds to infectious diseases such as corona viruses, then the DNA Company's one-of-a-kind Comprehensive Infectious Disease Risk Factor Report has the potential to improve your life. This report makes optimizing health straightforward: the results provide you with an organized summary of your genetic makeup as it relates to infectious diseases and a set of simple, actionable, and individualized recommendations that are tailor-made to your unique genetics. We want to let our listeners know about a special offer we have from our partnership with the DNA Company. You can order any of their amazing products at a discounted rate to include the Comprehensive Infectious Disease Risk & Response Profile, Comprehensive Functional Genomics Profile, and Male or Female Hormone Profile. Please go to our links above. Let us help you unlock your peak health! * About The Immunity Docuseries: Never has it been so critical and obvious that our health and immunity have to be a top priority. It's now up to us to make a choice: continue down a path of disease or do everything possible be to be at our peak health. Some of the questions explored in this series include: How can we be resilient to diseases and viruses to come? What actions can we take today to achieve peak immunity? What are the non-negotiables to building immunity? * This podcast wouldn't be possible without the support of Thrive Performance & Regenerative Medicine. A team prepared to go all-in with you to craft a personalized health plan to achieve your peak health. Book a free consult to start your health transformation at - https://thrivemedicineclinic.com/ * Thrive Medicine - @thrivemedicine Dr. Rhet Langley - @rhetmd Dr. Phillip Gallegos - @phillipgallegos_md Marc Champagne - @mchampagne

Get your notebook out, because today, Joe is going to geek out with functional medicine clinician price wild from Blue Scorpion venom and Spartan t to vitamin D and akinesia Bryce shares evidence-based tips and information that are part biohack part nutrition, and art plain old biology.   Bryce Wylde BSc (hons), DHMHS is a functional medicine clinician at P3 Health in Toronto with over 20 years seeing patients. As a leading health expert and co-founder of Youtrients, founder of mymmunity, author of four best selling books, previous host of CTV's Wylde On Health, and regular guest health expert / medical advisor on “The Doctor Oz” show, he is truly Wylde about health!   This episode of Spartan Up is brought to you by Orgain.  clean nutrition to help you stay healthy, active, and feeling your best? New subscribers save 30% at orgain.com/pages/spartan   LINKS: Bryce on Instagram @WyldeOnHealth More about Bryce www.wyldeonhealth.com Use Bryce's offer to save 30% at https://mymmunity.com/ with the code SPARTAN30   FOLLOW SPARTAN UP: Spartan Up on Instagram https://www.instagram.com/spartanuppodcast/ Spartan Up on Twitter https://twitter.com/SpartanUpPod   CREDITS: Producer – Marion Abrams, Madmotion, llc. Host: Joe De Sena Sefra Alexandra, Johnny Waite & Colonel Nye will be back soon, we miss them! © 2021 Spartan

Bryce Wylde BSc (hons), DHMHS is a leading health expert and clinician at P3 Health in Toronto, co-founder of Youtrients, CINO at Brain Armor Inc, author of three best selling books, previous host of CTV's Wylde On Health, and regular guest health expert / medical advisor on “The Doctor Oz” show.   His new book Brainspanners is available at Brainspanners.com. 

Today we look at how you can tell if you are predisposed to weight gain and hair loss.  Enjoy the show.  www.mikedaciuk.com

Dr. Mohammed is the Founder and President of ManaGene considered one of the most innovative leaders in the emerging personalized medicine and lifestyle genomics space.   In August 2018, ManaGene merged with Youtrients (www.youtrients.me) to form a new company known as The DNA Company. The DNA Company represents the evolution of functional genomics and is focused solely on the optimization of human health and performance.   Dr. Mohammed is widely regarded as a pioneer in medical genomics and has been the recipient of multiple academic and industry awards. He is the holder of several patents in the general fields of molecular diagnostics and genomics research and is one of the most sought-after national and international conference speakers in the genre of personalized medical genomics. In this interview, Lisa and Dr. Mansoor dive deep into the power that lies in understanding your unique genes to change the outcome of your health.   Some take the fatalistic view that if you have a bad gene or combination of genes you are powerless against them so it's best not to know but nothing could be further from the truth. Understanding your genes through DNA testing is like getting the user manual to your body and learning how best to care and treat it. The granularity with which you can start to understand processes and how these affect you and how you impact these is astounding.   This s actionable knowledge that will help you make informed decisions regarding your health in such areas as your hormones, your cardiovascular risk factors, your methylation, your detoxification processes and even your mood and behavior, why for example some have a tendency to more problems around depression or PTSD than others.    Never before in the history of the human species have we had such deep insides into the way our intricate and complex bodies work.    This episode is set to blow your mind and the work of Dr. Mohammed and his team is set to change the future of the world's health. We have the opportunity for the first time to take control of our own destinies rather than falling victim to our genes through a lack of knowledge.   Once you start to see and understand the power of functional genomics you won't be able to go back to the way you understood yourself and your body before. Your level of self-acceptance and the ability to help yourself heal and be healthy and whole will be taken to a whole new level.   If you would like to get your hormones or your whole genomic profile tested you can find out more at www.thednacompany.com    We would like to thank our sponsors for this show:   www.vielight.com   Makers of Photobiomodulation devices that stimulate the brains mitocondria, the power houses of your brains energy, through infrared light to optimise your brain function.  To get 10% off your order use the code: TAMATI at www.vielight.com   For Lisa's New Book Relentless visit the website below to order https://shop.lisatamati.com/products/relentless   When extreme endurance athlete, Lisa Tamati, was confronted with the hardest challenge of her life, she fought with everything she had. Her beloved mother, Isobel, had suffered a huge aneurysm and stroke and was left with massive brain damage; she was like a baby in a woman's body. The prognosis was dire. There was very little hope that she would ever have any quality of life again. But Lisa is a fighter and stubborn. She absolutely refused to accept the words of the medical fraternity and instead decided that she was going to get her mother back or die trying.   For more information on Lisa Tamati's programs, books and documentaries please visit www.lisatamati.com    For Lisa's online run training coaching go to https://www.lisatamati.com/page/runningpage/ Join hundreds of athletes from all over the world and all levels smashing their running goals while staying healthy in mind and body.   Lisa's Epigenetics Testing Program https://www.lisatamati.com/page/epigenetics/ Get The User Manual For Your Specific Genes Which foods should you eat, and which ones should you avoid? When, and how often should you be eating? What type of exercise does your body respond best to, and when is it best to exercise? Discover the social interactions that will energize you and uncover your natural gifts and talents. These are just some of the questions you'll uncover the answers to in the Lisa Tamati Epigenetics Testing Program along with many others. There's a good reason why epigenetics is being hailed as the "future of personalized health", as it unlocks the user manual you'll wish you'd been born with!  No more guesswork. The program, developed by an international team of independent doctors, researchers, and technology programmers for over 15 years, uses a powerful epigenetics analysis platform informed by 100% evidenced-based medical research. The platform uses over 500 algorithms and 10,000 data points per user, to analyze body measurement and lifestyle stress data, that can all be captured from the comfort of your own home   For Lisa's Mental Toughness online course visit:  https://www.lisatamati.com/page/mindsetuniversity/ Developmental strength, emotional resilience, leadership skills and a never quit mentality - Helping you to reach your full potential and break free of those limiting beliefs.    For Lisa's free weekly Podcast "Pushing the Limits" subscribe on iTunes or your favorite podcast app or visit the website  https://www.lisatamati.com/page/podcast/     Transcript of the Podcast   Speaker 1: (00:01) Welcome to pushing the limits, the show that helps you reach your full potential with your host, Lisa Tamati, brought to you by Lisatamati.com Speaker 2: (00:13) Hey team. We're this week I have an absolutely superstar, the world's number one leading functional genomic specialists, Dr. Mohammed from Toronto and Canada. Dr Mansoor, Mohammed has two guests now. He is a scientist and entrepreneur in the field of genomics and is regarded as one of the most innovative leaders in the emerging personalized medicine and lifestyle genomic space. Dr Mohammed is a PhD and president and scientific officer at the DNA company and is really considered to be a pioneer medical genomics. He's a classically trained molecular immunologist who has received academic and industry awards, published numerous papers and holds patients in the general fields of molecular diagnostics in genomics. Now functional genomics is about understanding the DNA and how it behaves in every definition and this Dr. Mentor was very different than many of the other DNA companies that I've looked at recently and that he doesn't just look at the single litters, if you like, of the DNA, but it looks in combinations of genes. Speaker 2: (01:22) And how they're playing out. And this makes him very, very different. This, he sees DNA like a language rather than a vocabulary and language that has grammar, sentence structure, Syntex and nuances. And you've got to be able to read genetic structure at the holistic level. Now I'm super excited about document's all his work and I'm studying functional genomics at the moment and it is the next level in personalized health. I'm really, really excited to bring this interview to you. It's taken me months to get documents or on this podcast and I'm hoping later on the year to get Dr. Mansoor Down to New Zealand for a lecture tour to speak to functional medicine practitioners down here as well as the public. So if you'd like to know more about that, please reach out to me and let me know. I'm just like to remind you before I hand over to Dr. Mansoor that my book launch is happening just next week over the time of this recording is the 6th of March and on the 11th of March. Speaker 2: (02:26) So by the time this recording actually comes out, my book will be live. It's called relentless and it tells the story of bringing my mum back after a major aneurism myth. You're fighting for a life and lift her in and basically not much over a vegetative state. Massive brain damage at the age of 64 and what I did to beat all the odds and bringing my mum back to health, all of the CRPS I used, the protocols, the attitude, the mindset, the obstacles that we had to overcome, the problems that I've discovered in our medical system in on it goes. So this book is really, I'm, I'm so pleased to be able to bring it out. It's taken me two years to get this together and to bring it to the public, but I really want to pay it forward and I want to help thousands and thousands of other people facing difficult challenges to take them are hit on with the right mindset to overcome great obstacles. Speaker 2: (03:18) So if you'd like to check that out, we can head over to my website. I have Lisatamati.com Hit the shop button and you'll see all of my books there and my jewelry collections. But make sure you check out the neatness. It's really going to be worth a read for anyone who has major medical problems at the moment. Or of course anyone who has a stroke aneurysm Alzheimer's dementia, and wants to know about brain rehabilitation or optimizing your brain function and who isn't interested in that as well as the whole mental attitude and mindset that it takes to do all this. So without further ado, over to Dr. Mansoor Mohammed. Well, hi everybody. Lisa Tamati here at pushing the limits. It's fantastic to have you back again. Now I am just grinning from ear to ear. I can't stop smiling because I've been waiting for this interview for weeks. I have a very, very special guest, Dr. Mansoor Mohammed, all the way from Toronto in Canada. Dr. Mansoor How are you going? Speaker 3: (04:17) I am great, Lisa. And likewise, it's been something that I've been looking forward to, to the audience. Please forgive me. I'm a little bit sleepy from Jeff blog from last night, but Lisa has been pumping me up and so we're going to have some fun of this Speaker 2: (04:31) Now. I know what it's like when you're a little bit jetlagged and you have a main very much in demand. So I'm just so excited to have a little bit of time with you now. Dr Mansoor, I do the whole introduction on a separate recording, but dr Mansoor, can you give us a little bit of background about your what you did your PhD in your, your, a little bit of a brief history of your back. Speaker 3: (04:55) Sure. genes. Genetics has always have always been my love. The study of how this operating manual, just just thinking, just, just dialing it back and thinking that the human being, we've got this operating manual that by every definition of the word it behaves like an operating manual. And to think that it's there and to think that one date might be accessible and that we could read this and we could read it intelligently and just simply understand myself much less, much less. Anyone else has always been my love. And so I started, my PhD is in applied molecular genetics and immunology. So I was looking at the genetics of the immune system. I was very, very fortunate to have an awesome mentor. She was then the chair of molecular biology at UCLA invited me to UCLA. So I had an awesome couple of postdocs there where I got deeper and deeper involved in eugenics. Speaker 3: (05:47) But a real pivotal point happened when I was done, invited to come to Baylor college of medicine and Houston, Texas. And it was that heavy time just about the human genome project, its, you know, sort of pinnacle. And I was asked because of the work that I had been doing with UCLA to come over to Baylor and start a company, the goal of this company was to begin looking at multiplex genomics. In other words, to really do the, you know, the barrage searches into the human genome. Not one gene at a time, but looking at the entire genome in pathway type manners. Now initially we applied this knowledge to cancers. We apply this knowledge to developmental disorders syndromes, Prader, Willi syndrome, autistic spectrum disorders and so on and so forth. And about 15 years ago, after many years of doing what I call disease genomics, looking at the operating manual, looking at when the operating money was broken out of what happens from a disease perspective. Speaker 3: (06:45) Then I sort of thought, okay, well that was fun. That was good. That was, but why should I not look at the operating manual? But nothing is purportedly broken, but just the operating manual. So then still we can tell presumptively healthy individuals how to stay healthy or how to get over the type of chronic illnesses. So this is what I've been doing for the last 15 years, studying, researching and applying the knowledge of the human genomic operating manual. So we've been, we can just simply understand it. How does the body work, which clearly there's an individuality to that, obviously. I mean, we are human beings. We all, our cells, our organs, our bodies, all have to accomplish the same jobs that we do. These jobs with nuance differences, some of us less optimal, more optimal, more efficient, less efficient. And when we can zone into that, when we can read this operating manual from that perspective, really Lisa miracles happened with the sort of insights that you get, the nuances that you can tease out. It really has transformed the clinicians. We train the patients, we work with the transforms, it empowers the individual to understand how their body works and what they might do to obtain that optimal health. Speaker 2: (07:59) This is, and this is a super exciting and I can feel your passion coming through despite the jet lag for this area and it's now mind you, passion is of the last maybe two months or six weeks or however long it is now that I've been diving into this world and just going, Oh my gosh. Oh my gosh, this is just, this is just the next level and the information that I've been searching for to try to understand because everything seems so generic. And this a personalized house and yeah, doctor man saw you the president and founder of the DNA company, which is offering direct to public and in conjunction with conditions. A couple of reports. So our full genomic report in a hormone report and I want to tease apart a little bit today, why should people even consider having a look at these, the sort of testing what benefits they can get out of it. Speaker 2: (08:58) And I'd like to also tease a little bit about looking at other, like I've, I've looked at a lot of gene companies and that do gene DNA testing. And you had an analogy on a Bulletproof radio that I heard you on the same show who's amazing Dave and his work that was about the most people are looking at it DNA as a vocabulary and not a language. And that just seems them light bulb up in my head where I realized, okay, so it's not the siloed genes looking at them individually, but looking at cascades and pathways and combinations of genes as we are then interpretation has been missing today. Speaker 3: (09:43) Oh, 100%. So I always say, you know, Lisa, anyone that is in the data business, regardless of whatever data you're collecting, data is really quite dumb. Data in and of itself doesn't mean anything unless you know what to ask of the data unless you know how to triage, how to approach the data. So when we use the analogy as DNA, the operating manual, the genome, it really meets all the classifications and descriptions of a language. Thus far we've been looking at DNA and genetics from a language perspective purely as a vocabulary exercise. The more words we know, the better we presume to think we know the language. And as much as that is important as per the analogy that I drew with on Dave, show a person simply knowing more vocabulary by no means mean they understand the language. And so when it comes to DNA, when it comes to genetics, when it comes to how this awesome operating manual, the architecture of it, it's not just about vocabulary, it's not just about the individual genes. Speaker 3: (10:51) So here are the two layers implicit in your question that we do a bit differently and why we need to do that differently and why it's important that it's done this way. The first is this. When you're looking at the DNA, if the person are either genetic makeup, the vast, vast majority of companies right now, they're looking at things called snips, single nucleotide polymorphisms. In other words, they're looking at places which is absolutely important. They're looking at spelling variations in this operating manual. And of course these spelling variations, these single nucleotide polymorphisms will impart to you mean Jane, Paul, Peter, the same cellular job that we all want to do. These spelling differences can impact the efficiency with which we do that job and that is important to know, but while we're at that point of spelling, you see per any language, if I wrote a paragraph, I might have spelling errors in that paragraph, but there are examples where I may have inadvertently deleted a sentence or deleted a couple of sentences in that paragraph. Speaker 3: (12:00) Now, if the analogy here is that the gene is the paragraph, so your operating manual are these 23 volumes. Think of it. Think of a 23 volume and psychopathic set these awesome, huge volumes. Now we're going to inherit two of these 23 volumes. One from mom, one from dad, and these volumes are properly arranged and when we open up any page, let's say we go to volume three from mum volume three from dad, we open up page four on each of those volumes and we look at paragraph five page four, volume three we, I see the same paragraph. We're going to see the same information from dad's gene paragraphs of genes and mom's gene. We're going to see the same information, but when we look really carefully, when we look at those paragraphs, really collect carefully, we might find that there's some spelling differences. Those are the snips. Speaker 3: (12:57) We may also find that on either dad or mom's paragraph, a sentence was missing and I just taught this over the weekend. So I was in the auditorium and I said, okay, here's an instruction that was waiting for me coming to this auditorium to give this lecture, Dr Mansoor, go to auditorium B and to the left door approach to podium from the right side, press the enter button, begin your lecture. That's an instruction. That's a paragraph. That's an instruction and that's the equivalent of a gene. Now in that paragraph they make has been a few spelling errors or changes that may have confused me a little as to what the instructions are. But when I look at it carefully, I could sort of still figure it out. Okay. But if in that paragraph, the sentence that says go to auditorium B was missing at, of course there are multiple auditoriums, all of the other parts of the instructions are there. Speaker 3: (14:03) But I can really be confused as to what is the ultimate thing that I'm supposed to do. It's called an indel. So in our genes, not only do our genes have slips, many important genes actually have places within them that I'm missing. So until we test for those type of changes, we're by no means getting the full picture of what is happening. The third thing is this, not only do we have slips, not only do we have in Dells, there are occasions where the entire gene is missing is show I'm supposed to show up. I got to the hotel where the conferences are and the instruction just telling me what it's just not even there. So here I'm in the lobby going, I don't know what I'm supposed to do. This example is a genetic phenomenon keeping the analogy, this is called this C and V copy number variation. Speaker 3: (15:03) We see because we were supposed to have two copies of that. Paragraph five page four, volume three. Sometimes believe it or not, when we go to page four we've opened up mum's volume three dad's volume three. There they are. We're going to read both of the instructions cause that's what yourself has to do at any given moment. When there's a job to be done, your cell goes and pulls the volume that has that instruction, takes down a mum's copy, takes down, dad's copy, opens up and reads the instruction. Now in the case of a CMV copying of the variation, we can open up mum's volume three page four there is paragraph one, paragraph two, paragraph three paragraph four paragraph six. Oops, wait a minute. Where's part of our five? It's gone. There's part of four. There's part of six. I look over a dad. He's got all of the paragraphs or vice versa. Speaker 3: (16:02) Sometimes Lisa, both paragraph fives are gone. Okay. So the point of the first answer to your question, why we do things a bit differently is we're not just in the business of collecting data for data's sake. We're collecting data. Are you were doing gene testing to understand a process. When we designed genetic tests, we don't begin with genes. We begin in a whiteboard saying, what is the thing in the human body that we want to study? What is the thing that we want to study? Genetics, just good old fashioned medical textbook, human physiology. Do we want to study the way the newer chemicals are produced and bonding and response? Do we want to study how the human body makes sex hormones? Something we should talk about when it comes to human performance. So how does the male and female body makes progesterones androgens Astros? And then we mapped that out. Speaker 3: (16:56) Forget genetics, which is not about how does the human body do that? No, of course, if the human body's having to do something, then it means there are genetic instructions for that film. So only when we map out the cellular, the cellular biology, the cascade, only when we met that out, then we come in and we pencil it. This gene is responsible for here. This gene is responsible for there such that at the end of the exercise, we've got a genetic test that already tells a story. The result from that genetic test is telling you the entire cascade. Step one, step two. We look at each of those genes that are telling us the story and we ask are these snips that are important? Are there entails that are important? Are the CNVs that are important because all three make a wow. And so the first part to the answer to your question is if you've been looking at genetic tests that are only reporting snips, you are dramatically limiting the variations that you and I and every other person have within our genome. So you're missing the nuances that are in your language to clarify the job to be done. Does that make sense? Speaker 2: (18:16) Absolutely. So that actually puts them together in my head because I've been starting this, I don't know, like for example, the GSTT one gene and the detox and antioxidant pathway, one of those types of genes that can be completely done. Speaker 3: (18:31) Completely. Totally said, absolutely. And of course it belongs to super family. So there are multiple G S T genes, but two minutes on that. If you're going to design the human body and you're going to say, listen, one day we're going to make this thing called human being and we're going to put him or her in this wonderful world, but mind you, he or she is going to have to deal with some toxic insults, both from without and from within. Where would you, and you know that, where would you put your detox defenses? Well, they're about four places. If you're an intelligent designer, you would put your detox, different defenses at least in four places. You would say, how and where do things get into the human body, dermal skin, the nose, nasal Bronxville lung, the GI track. Okay. So those are how things get it. Speaker 3: (19:23) And unsurprisingly you would want to make sure your detox genes and the things that you'd want to make sure there's super active in those places. And then you, you'd also say, well look, at the end of the day, things are always going to get past borders inside of the body, their waste products. So then I'm also going to put a detox organ. The liver, when we go to the human body, this is where we find these detox genes expressing themselves. And each of the GST is have sub specialties. Some of them are more important in the nasal bronchial track, some of them more important in the GI track and so on and so forth. So when you know the story that you want to read about the body, you know how to read the manual and interpret, is the GST T one gene deleted or not? This is a massive implication to the human body. Speaker 3: (20:16) Can you imagine the GSTT one gene is one of, if not the most important bio transforming antioxidizing enzymes in the body per its name and its gene and its enzyme. And if a person doesn't have it, literally it's not in mere manual. The GSTT one gene is on volume 22 and if that paragraph you have not inherited it from either mum or dad, you are missing an enzyme in your body. That is one of the most important detox. Now doesn't mean that you're not compatible with life, but it most certainly means you could not be the person who says, well you know what do you have a metals mean after all they're not that bad. Oh you know what, my uncle smoked until he was 80 years old. I'm going to smoke as well. Well you can't compare yourself to that person cause you don't have one of the most awesome detox genes. Speaker 2: (21:13) You don't have a good defense mechanism. And so like the detox is actually the first port of call before the immune system even does this job. So I'm, I'm excited to get my tests back cause I haven't gotten gotten through the reports yet. I'm, I'm suspecting that I have a problem in my GC jeans because I'm a very young age. For example, I've been the next medic as a, as a severe asthmatic, as a child, and I'm very hypersensitive to smells and anything. So I'm like a Canary one C one, which is theta. Yes, Speaker 3: (21:54) Very important in the liver. Key one PI GSTP one is the one that's really important in your nasal bronchiolar lung cavity. Individuals with a suboptimal P one are at extreme risk of early ectopic asthmas. They're the ones that if they go into the shopping mall, you know, the perfume resection, they've got to avoid the perfume resection. Right? Those are the GSTP ones. Speaker 2: (22:21) Wow. I'm obey. Fascinating to see if that's what comes back. And so if you want it deleted into them, we'll get onto hormones next because I really want to dive into there, but just to, to to look at the GST genes. If you don't have, you either have only one inherited GST, one gene, your mother or your father and you're missing the other ones or you're missing both altogether, are you more likely to have you're more likely to have toxins coming in that you can't deal with as well. And then your immune system is this way or auto-immune or part of the Speaker 3: (22:57) Brilliant, brilliant question. Just before we answer that, I had mentioned there were two layers to differentiate yourself, so just so that we close the chapter on what we do differently. So I'm going to come back and, and so now we will take it forward. We just mentioned that there you have to be mindful of the three different layers of variations, snips in Dalles with pieces of the genome missing and CNVs where the whole gene may be missing. The other quick differentiator, bringing back the analogy of a language, bringing back the story of the human body, it's this, and I told the audience this, there was an audience of clinicians in Phoenix this weekend. I said, have you ever read a really good, you know, suspense novel and not suspense novel, the novel that the author's painting the character and you're thinking he's the bad guy, you know, and he's falling around the heroin and he knows he looks a bit shady. Speaker 3: (23:51) And then until or unless you've read the entire book, you only find out that he was a protector or he was something. He was a guardian and words. He wasn't about that guy. Now what the heck does this have to do with genes? The second player, when we mentioned that we do things differently, we said that DNA is really a language by all of its definitions, with its nuances is this, there are many genes, Lisa, where if you were to look at that gene as a standalone and if you was to look at the genotype of that gene, in other words, what version do you have? You think you have either the best version or the worst version depending, and you may think you have the best version for example, but it is not until you look at a completely independent gene that has nothing to do with this gene, that the version of that independent gene wow colors, whether your actual optimal version of gene a will stay optimal or not. Speaker 3: (24:52) Or conversely, whether you thought you had the suboptimal version of a bad guy, you read the full story, something else tells you what you fought was the bad guy was not the bad guy. Wow. And this is what it's called at peace basis. You see we're all concerned about epigenetics, which is important. FP genetics. How are we reading? Are we actually going to read that paragraph on the page or are we not going to read? That's at the genetics, but nobody's talking about epi. Stacy, this is Stacy. This is often, we've read the page after we've read the paragraph. We cannot yet make a conclusion until we read 10 pages later, 15 pages later, something there. We'll bring it to life. We'll color what we read on page three. Speaker 2: (25:48) Yeah, so, so for example, if you're, if you're looking at a specific gene and it has an, that is say the faster for the sip, 79A1 gene and the hormone a kiss guide. If it's a fast one that's not in and of itself a good or a bad thing. It depends on the other things. It depends on the, so that's what you're meaning. So one of Speaker 3: (26:14) The best examples of that is this, the BDNF gene, the BDNF gene, brain derived neurotrophic factor. What are the most important genes in the brain? Well, in the whole human genome that tells the brain how to secrete this awesome thing that heals the brain. You and I were having a conversation about a loved one, so that loved ones B, D and F was going to be hugely important. And how that loved one recuperated from the challenge that she had met BDNF. Now the beating of gene has an important variation. A snip this time, which is either a G version or a version. Okay. TheG version, Jews and George as in guanine is the optimal version of BDNF, the optimal version. So if you're a GG blessed, that's good. You are naturally predisposed. You have the in Harrods, the innate ability to make more BDNF. Speaker 3: (27:13) And let me tell you that's a good thing. Any which way you slice it. Wow. An independent gene, the TPH to gene the trip to five hydroxylase gene to TPH, two gene, which is involved in how the body deals with serotonin. K two has a sip. It comes in a G version and a T version G as in George T as in Thomas. The G version is considered optimal but hold on. If you happen to be GG fatigue, pH two and GG for BDNF ostensively both those genotypes for each affair genes are optimal, but if you were GG for both, it creates a haplotype. It creates a combination that is an act risk combination and it is, it is the negative combination. It is the, it is the deleterious combination when it comes to certain aspects of human behavior. These individuals, when you're GGGG, they exhibit poor inhibition of negative emotional stimuli. Speaker 3: (28:28) In other words, when something negatively emotionally affects them, their ability to kinship, the ability to say, you know what, I'm not going to focus. I'm not going to hamster wheel constantly play that over and over over again. They haven't, they have a hard time giving up that when something gets under their skin. So to speak emotionally, they have a really hard time getting over it so they have a strong imprint. The memory imprint, very strong EMI, emotional memory imprint and of course the stronger you EMI emotionally memory imprints, the easier you emotional memory recall EMR is because the deeper something is imprinted then the smallest cue. You have a love, you have a partner and you know you love each other to bits, but like human beings, you're going to have your ups and downs. I mean it's where human beings after all, and on one particular evening you were both getting on each other's nerves and she was wearing that beautiful red dress and that was the evening that you both said things you shouldn't have said and it hurts the person who has this phenomena. Speaker 3: (29:36) Whenever he sees his wife, would that red dress down the road, everything's perfect. You, you're going up for a birthday party, you're both happy, it rises back up. He remembers that evening more than he should. It brings back to the surface and vice versa. This is that Paul, inhibition of negative emotional stimuli that lead to profound memory imprinting and therefore profound memory. Recall. The point of all of this and the reason I mentioned this is, and we're going to come back to the GSTT one, was to clarify, you see Lisa, it's not just about even the type of things you're looking for. What matters is the interpretation we sell the combination, we are reading the manual, not just flipping, picking words out. Speaker 2: (30:24) This is we have a calmer is well we are the, the apostrophes are this is someone that is what they would be more prone to PTSD Speaker 3: (30:36) 100 that's the point actually and that is further exacerbated based on the no adrenergic pathway which dramatically increases the risk of PTSD. It is exacerbated based on how quickly they are removing their dopamine and noradrenaline via content. So what happens is you begin to pixelate a picture and you've got a low resolution picture and then the more intelligence information you put in, you start to increase the resolution of that picture. You start to get a clearer picture of the person that you're looking at. But to do so, you've got to know where to pick slate. If I'm trying to get a better look at what Lisa's face look like, I don't really be pixelating your toes. I need to pick slick your face and this, this ability to read intelligently. Lisa, I stress intelligently. Riyadh, human genome. Yeah, that's what we do. We do Speaker 2: (31:35) That is absolutely insane. And they've vacations because yeah, I would have seen, Oh, you've got a G G G is good, but I've just understood that nuance, that combination of things. And now I can't wait to get my reports and my family reports so I could because this helps us also understand like the speed in which you are dopamine is processed and gotten rid off or the speed of which we're saratonin tone and all of these things have a fixed on your personality and that we're not 100% to blame for some of our differences. Speaker 3: (32:12) Oh gosh, no. Gosh, no. In fact, what this needs to do on the one hand, it creates the empathy of appreciating, look, this is how some of this is their predisposition. Now, on the other hand, it is not to create a sense of fatalism. While that's the way I am, I know I have found and I have done. The only thing that I've done, probably somewhat unique and special Lisa, is I have reviewed thousands upon thousands of profiles. In terms of my in the world, most of my peers that work at the level I do would say Dr. Mansoor Probably reviewed the most genomic profiles in the world. I don't know if that's true or not, but I certainly have reviewed several thousand meaning meeting the patient, speaking with their doctor, looking at their health profiles and looking at underlining genetic phenomena to see if we can understand what's going on. Speaker 3: (33:00) You know what I found, at least as a fellow, when you empower a person to understand a predisposition, you, you might think that leads to fatalism, but when you explain the functional reality, it actually does the opposite. It gives the person a sense of ownership and then they can finally say, you know, I have dumped with my entire life, I've been this way and I just, I didn't even know why it was that way. Now that I can even understand what's going on, it gives me some closure. Yes, but it now gives me something to appreciate. I can, I can envision how this is working, how my emotions are working. I can now go, you know what? As soon as I see that stimulus that would have got me on that slippery slope, I'm going to stop. I'm not going to go down that slippery slope because I know if I do, there's no coming back for the next two weeks. Speaker 3: (33:52) So what we've found is that this crew all around it just creates empowerment. Which brings me now to the question that you asked about GSTT one and you are, your connections are on point, Lisa, the connection between the detox mechanism of the body. Here's the threefold, and of course it's a bit more complicated, but it's also remarkable. You can take complex systems, break them down to building blocks and keep the acuity. So there are three building blocks we need to look at when we connect detoxification pathways in the body and the immune system. And the, the only thing missing is the inflammatory system. So the triangulation between toxins and immune responses goes like this. The human body's insulted with whatever. It's insulted with the intentional, the unintentional of our daily lives, those toxins enter the body or they try to enter the body. Step number one, how individually efficient is that person at negating bio transforming, neutralizing those toxins either before they can enter the body, such as in the mucosa of the lung, the alveoli lumen, the the lining of the lung, such as the GI mucosa and so on. Speaker 3: (35:16) And so what can we, can we neutralize it so the toxin doesn't even get into the bloodstream? And of course to the degree that it gets into the bloodstream, can we live a hepatic re detoxified so that at least it does not by you accumulate in the body so that at least it does not reach levels that are unsafe. First step number one now too, there are genes, there are whole gene families, their whole cellular processes, GSTs, glutathione, ionization, UGI, Ts, glucuronidation, methylation, self, phonation and acetylation. These are the major enzymatic steps linked to genetic genes that are responsible for bio transforming neutralizing things in our body, okay? So what we need to do is we say, what is the lifestyle environmental context of the person? What are they getting exposed to? I'll be living in a home that has written with mold, are they living and so on and so forth. Speaker 3: (36:17) Okay, step number one, step number two, how good are they at individually neutralizing those toxins so as to not bio accumulate them to the degree that those, whatever. The answer to that question is we're going to have an individualization and with some individuals are better at getting rid of toxins and others are not. If a person is not genetically, innately efficient, optimal at getting rid of their toxins, then what happens? Well, what do toxins do? Toxins cause cellular inflammation, okay? And they cause inflammation via any number of methodologies. They can inflame cell surface receptors, they can get into the cell and create overproduction of oxidants as they can hamper the energy modules, the mitochondria. That's one of the places you'd never want toxins getting to. And of course they can get into the nuclear eye. They can get into the libraries of the operating manual and they can start to change gene expression. Speaker 3: (37:23) So toxins do all of these things. Ultimately, you see Lisa 15 not even 15 years ago, 10 years ago, if you told that a medical conference, there's this concept of inflammation. You'd have a lot of professionals. Well, come on, you gotta be more specific than that. We actually now know that there is a phenomena called chronic inflammation, and regardless of what stimulated that inflammation, bat bacterial toxin B, it's an inorganic chemical. It be it a physical inflammation. It does not matter the way the sun looks, the way the cell begins to behave when it has been insulted with toxins, with exposures, remarkably is the same regardless of the stimulus. Because chronic inflammation has hallmarks that are similar regardless of the stimulus. Now at that juncture, when the cell is inflamed, when the machinery in the cell isn't doing the job that it's meant to do properly, that cell now starts to be like this pulsing red thing just by analogy. Speaker 3: (38:35) In other words, the body is looking at it going, something's happening in there. It's not behaving the way it should. Okay, so now we're going to have two steps. The body now has an anti inflammatory set of steps to quiet us, to bring the cell back into line cause they Whoa, Whoa, hold on. You're starting to misbehave. There's too much inflammation. This is where it's selling the process known as methylation comes in. Cellular methylation can be viewed. It's a detox reaction by the way, but it is a cellular cascade that is radically responsible for bringing your soul from that humming, inflamed, you know, ticking bomb type of modality back down to acquire essence behavior. That's cellular methylation. Now, to the degree that you're able to do that, because suddenly methylation is a multigene cascade, multiple places where things could be not as optimal as we would like. Speaker 3: (39:36) So to the degree that we then triage, we stratify the patients based on their detox potential. We then stratify them based on their anti inflammatory potential. Now, to the degree that we are not quite yessing that chronic inflammation, this is where the immune system can be activated. Immune system was meant to be activated in acute episodes, not chronic episodes. The more you ask the cell to produce antibodies, IgG, IGA is IGMs, particularly IgGs. The more you keep telling that the body pump out IgG, something's not working right, something is there, which is why chronic infections are now very well understood to be linked to autoimmune diseases. The infection did, did not go away, constantly demanded of the body to produce antibodies. And somewhere along the line those antibodies begin to forget what was the bacteria or what and what was the self. And now we just start shooting friend and foe alike. Wow. This is the triangulation that has become now a focal point of so many diseases. Some diseases being more relevant to the whole, you know, things like lying disease. Do you guys have lung disease down in New Zealand? Speaker 2: (41:05) I think, yes, we do. And I think you know we have a massive problem with like thyroid, Hashimoto's sort of autoimmune diseases, crones, IVs. So this is, this is where the body is actually going in overdrive. So the, the original detox genes haven't been able to do their job because combination. Speaker 3: (41:26) There's that one. Exactly. There's inflammation. Yup. Speaker 2: (41:33) Yes. Speaker 3: (41:33) Methylation didn't do the job that was supposed to do and now we're triggering. So there are meta-analyses meta-analyses that show the deletion of the GSTT one gene or overall poor Ghouta finalization has been strongly linked with ulcerative colitis, Crohn's disease, IBD, strongly linked with ectopic asthma, particularly GSTP one in early childhood asthma. Then of course, if you, if you double down on poor math on poor detoxification with poor methylation, you really start seeing Speaker 2: (42:10) Clinical outcome. Yes. Yeah. So, so if we then we, we, we find out all this about ourselves. We find out we've got either the good or the bad and the ugly. And these combinations are not ideal. Then how, you know, we've got this information now, now we want to know what the heck do I do about this? I can't change my DNA. Of course, all things that these reports that your company does, for example, where it can actually lead to some successful outcomes. Obviously avoiding cigarette smoke or exhaust folk tunes and things your GPS deleted. But, but beyond that, nutraceuticals, new nutrients what can be done to help people. Speaker 3: (42:52) So it starts with, so the first thing I would have to say is we take our reports only so far. So the actual report, we take it to the point of explanation of what's happening. And there are certain recommendations, but the real magic must still come from a trained population, you know? So what, so what we do is through also training a certain class of healthcare providers. We might call them the, the new modern day biohackers. The healthcare providers who are really sniff, they're no longer just, you know, pill pushers. They're looking. So I just wanted to clarify. We take the reports, we explain the systems, we explain what's happening, but we also have to be careful so that people aren't jumping to conclusions and self-treating based. So you still want to have someone who understands the bigger picture. And by the way, that's the second part of what our company does. Speaker 3: (43:47) As per my travel schedule, I'm constantly traveling, teaching people, teaching auditoriums full of doctors who are now saying, listen, if I keep practicing medicine the way that I'm practicing, I'm just dealing with a disease population. I'm not healing people. Okay, so with that minor clarification, now we come to, let me paint a picture, paints a thousand words not to be, you know, blahzay here's what I like people to picture and here's what you would want to picture for yourself. Lisa. Picture slide. Okay, so there's a slide your screen, okay, and a circle. And then picture a circle on that screen somewhere on your screen. There's a circle. Now because you're a human being, your circle is going be on the screen. In other words, this is the screen of all human beings and your circle, you, your circle is somewhere on the screen or what does the circle represents? It represents your genetic makeup, which represents a part of your genetic makeup for whatever biochemical process we were studying. So this circle is Lisa's genomic pathway. Okay. Speaker 3: (44:56) I want you to then think of an equilateral triangle that equal three sided triangle that just perfectly encompasses your circle just perfectly. Your circle is perfectly encompassed just right in that triangle. And the emphases of this triangle are labeled environment, lifestyle and nutrition. Yes. What we're learning and what we're recognizing more and more is other than extreme cases, other than extreme cases, and there are mind you extreme cases where a particular genetic combination was really just a real doozy. And in other words, we're going to see some, you know, with the best of efforts, we're going to see some probably deleterious outcomes. Fair enough. But other than those extreme cases, for the vast majority of us, the spite, any inefficiencies we might have if we find the right triangulation of lifestyle, nutrition and lifestyle, nutrition and environment. If we could figure that out and it perfectly matches, I would circle. Speaker 3: (46:08) This is optimal health. So image, the image of optimal health is when you can find your genomic makeup, your circle for whatever you're studying and contextualize it perfectly within the right for you. For Lisa Laughlin, sir, not for Joanne Felisa. What is leases? Optimal lifestyle, nutrition and environment. Now the problem is, Lisa, when we begin working with a patient, obviously and clinicians with their patients, the vast majority of individuals, they do not know their circle. They don't know what's the economic influence. So they don't, and if you don't know your circle, your triangulation, choices of lifestyle choices, nutrition choices, and environmental choices offers skewed and they are not synergistic with your circle. So first objective of this, did you get that picture? Do you know when people say, well, it depends on your genes, your genes. It depends on how you're using your body. If you are, if you took, if you took five identical individuals, they were, you know, quintuplets identical, contemplative. Speaker 3: (47:27) If such a thing exists in today, the same genes and you give those five people at 35 years old, the exact diet. But if those five, one of them was an ultra marathon runner and extreme sports enthusiasts, the other was a couch potato, I don't know, doing whatever the other was a, you know, an accountant who had a nine to five job. We can exercise worrier, but from Monday through Friday really just goes to work, comes home, eats, goes to that and so on and so forth. Even with the same jeans, you can put the nutrition and an obviously not expect the same outcome because they got to know the genomic legacy. You've got to know what is the lifestyle context, what is the nutritional context, what is the environment or context? If one of the things quintuplets moved from your gorgeous country and move to massive metropolis with, you know, air quality, that breathing for one day is the equivalent of smoking a pack of cigarettes in your beautiful country. Speaker 3: (48:36) He or she may have gotten away with a GSTT one or GSTP, one suboptimal ability. He's living in those, you know, that wonderful country views. He's practicing otherwise good, not eating foods with pesticides and herbicides and so on and so forth. And he was going about life actually, not really realizing there was any suboptimal ability until one day his job took him to a big metropolis somewhere. He lost track of the quality of his foods. He's just so busy. He's day in, day out breathing the equivalent of a pack of cigarettes and then six months into this, all things ELLs as equal, his jeans are equal, but he now starts to show symptomologies that he would never have had any different environment and a nice clean environment. Right? So this triangulation is so important. Now coming back to the specifics, once we understand the pathways, we begin first with the dose. Speaker 3: (49:31) It may seem simple, but it actually enters Lisa into, it's not just about the obvious things that you might imagine. I give the example, Lisa, and by the way, it's relevant to the GSTT one gene. Now, juice, TT. Let's focus on the T one. It's the big sister in the glue, the fine fabric. So GSTT one no, it's what's called a phase two detox pathway. Phase two detox. Because when it talks and enters the human body, we typically go through two steps. We take toxin a, we converted into an intermediate B. Yup. We take B further, convert that to C. C is what leaves the body, the B to C part of the transformation. That's where the GSTs come in. The a to B. This is where your cytochrome P four 50s come in. That's the phase one. Bio transforming enzymes. Now if I were to ask you something, when you say fiber to say, would it be a good practice for person to start drinking a nice cup of green juice? Speaker 3: (50:38) You know, like some juice, juice, broccoli and some maybe put a little bit of a baby spinach in there. A bit of ginger, maybe some cute, cute curcumin at the end of it. Would that be a really healthy drink? Yes. Something I do every day. Beautiful, beautiful. And it is healthy generally speaking. So now someone puts a blog together giving this recipe of something that's ostensibly so healthy and there's this mechanic who works in a shop all day with fuse and so on and so forth. He read this blog, she read this blog and she decides that before she goes to work, she's going to have this beautiful juice. This green juice that they read was so healthy and it was a detox juice and they feel good about themselves. Hold on, hold on. Many of the ingredients and not green juice. Many of the ingredients in that green shoes turn on certain phase one sip four 50 enzymes so as to accelerate the conversion of a to B. Speaker 3: (51:54) Now some of the toxins a that this mechanic was facing in her shop, in the, in the, in the mechanic shop that she was working at, when she converts a to B, we know that the B, the intermediate is truly more toxic than wow. And by the way, she did not know she was a GST one deleted individual. Oh, so what did we do to this young woman? We encourage the things that is that we're getting into her body. When she drove that beautiful healthy green juice, she more rapidly converted her A's into B and then ups B's and to CS very well. Wow. Even something that would ostensibly be really healthy by normal standards. Do you see that's a healthy nutrition on the triangle, but we did not ask what was the environment on the triangle and so now we have skewed her triangle away because her genetics circle, she does not have the GSTT one. Do you get that picture? This is a little bit frightening for people who are listening to this or who might be going well, what's the point being? Speaker 3: (53:16) This is weird. The reports have the super value, isn't it? That's the point. It's, it's actually not discouraging. It's, it's finally, and this is all gold. It's finally meant to unravel those nuances that there is such a thing. Have you been? How many of us, you know, we do something that 20 or the coworkers swore was the best thing since sliced bread and then we tried it and not only did it not work, we actually felt like crap or less healthy, and we, we're all aware of this until it's what is it led? It's led for most of us to become numb. We're just kind of get to that point where we're like, well, I don't know what's right for me or run for me. Plus today it says one thing tomorrow it says another thing. So creating some sanity from this confusion is what this goal is about and it can be done. Speaker 3: (54:11) Lisa, when you take your time to read things, intelligent meals, explain things. That's why we've got these epiphany moments that constantly, I like my consults with patients because I feed off of the energy. When a patient just, you see that epiphany admission and they light up and they go, Oh, that's why this hasn't been working with. That's why that was better for me. That's why I took methyl B12 because everyone's telling me methyl B12 is the best version. But every time I take methyl B is it just in my head. I get a headache every time I take micro B12 I get a, and then I go, no, actually I got one too. I can't take methyl before. That's an actual thing. I can't take methyl B12 because my methylation cascade is inconsistent with me taking methyl Beto when I take a dental Sobe 12. Oh, completely different. Speaker 2: (55:07) Wow. So this is getting really granular for each individual. And this is what makes me so excited. And, but before we go on, we have to go and cover off the hormone report. This is something that I and, and this is, you know, for me and any woman, but I wanted to focus a little bit more in on the woman. We've got very complicated hormones, households, but this was the cascade for men and women is very, very similar, isn't it? Yes Speaker 3: (55:33) It is. It's just remarkably, this is what we taught at the cost on the weekend after introducing genomics, it was the first open to eyes that the cascade, the circadian rhythm with which the human body converts progesterones into androgens, androgens to estrogens, men, we do not have a monopoly over androgens. Women, you do not have a monopoly over estrogens. In fact, your estrogens come from androgens. Men, we have estrogens. It's just a matter of the circadian rhythm. When is it happening? How quickly is it happening? And of course, ultimately how much of any of these hormones are produced. And then the final component is how responsive are you, the the woman's body, all things equal. She's designed with the estrogen receptors to be more responsive to estrogen. She responds to androgens as well. Conversely, for men. Now keep in mind something as simple as, I can't believe how many clinicians do not realize how an androgen or estrogen receptors. Speaker 3: (56:32) Now let's stop there for this cascade. We can talk about all of the things about how hormones are produced and how they're metabolized and so on and so forth. But ultimately, how is estrogen affecting your body? Lisa, you're a young woman. You're making estrogen as if you're menstruating or if you want hormone replacement, there's likely some estrogens in your body, one way or the other when estrogen binds to your estrogen receptor. And to the degree that that can happen, mind you, because there are variations to that fidelity, this complex estrogen. So the estrogen receptor androgen to Stastrom, DHT to the androgen receptor. These complexes are some of the most potent DNA transcribing complex. They go into the nucleus and the churn on genes. This is how estrogen and testosterone impacts the human body. They live. They're not just, I don't know, causing breast development or, or, or, or Andrew demise in the book. Speaker 3: (57:39) They do that by churning on the genes that cause the cells to behave in a more underutilized manner or more estrogen. So the first thing I want, our audience needs, our clinicians, we need to re re climatize reacquaint ourselves with that. These hormones potently DNA transcribing, they go into the nucleus and they turn on and off genes. That is why they are not to be dealt with trivially. Number one. Number two, in a menstruating woman. Now I just told you when estrogen enters a cell, I did binds its receptor. It's not just staying in the, in the Maloo of the South, it's going in to the volts, the nuclear volts and churning on and turning off genes. Wow. When you look at the ministerial cycle of, of a, of a relatively normal, repeatable menstrual cycle, you will notice something radically important over the course of 28 days. Speaker 3: (58:43) The human female body isn't exposed to estrogen at the same amount every day, not at all. The human female body in 20 days only has about a six day or so window in which your estrogens that are really elevated and then it comes down. In other words, what is this telling us from a human biology perspective? It's saying that the type of gene expression changes the epigenetic phenomena that estrogens cause on your operating manual. You don't want that to be consistent and constant across the month, and this is very frightening when you look at contraceptive pill or hormone replacement therapy. So it's most certainly very frightening. That is not, let me be clear. That is not to say that there isn't a place or a time for these things. You know they are absolutely a young woman has to have the right to how she treats her body and what she does. Speaker 3: (59:47) But there is a place in time you at least be equipped, at least be empowered before you make this decision as to a knowing what it's doing for you. Say, okay, look for these few months of my life, for these couple of years of my life, this is going to be a bit more important that I take these precautions, for example, but you should know that to do so indefinitely, month after month, year after year. Now they've got clinicians encouraging young woman not to even have a bleed through. There's no point for even the bleed. So just stay on the, you know, constant level, 24 seven three 65 15 years. How is this compatible with normal human physiology? When you understood what I just said? Yep. Now let's go a step further than that. You see estrogens do what we just said. They bind their receptors, they go into the cell so they go into the nucleus. Speaker 3: (01:00:47) They change gene expression as they're meant to for brief periods during the month. Fair enough. Now, once those estrogens have done what they've done for those days, then the point of it is there's a circadian rhythm. The body breaks down those estrogens metabolizes them by a transforms them so that they're no longer active. They've been neutralized, and then we hit repeat, rinse and repeat, and we start a new cycle. But here's the point. Every a woman, Lisa, every a woman, a man for that matter, but let's focus on the ladies when she made her estrogens or she took her estrogens, because even whether you take it or whether you make it innately or you take it, it doesn't matter. You've got to metabolize the estrogen. Now, every young woman can metabolize estrogens into three byproducts. I estrogen 400 Z estrogen, 16 hours for hydroxy estrogen. Every human being does this, and this is a crucial point. Speaker 3: (01:01:49) Absolutely. But these three metabolites do not impact yourselves in the same way you say. If you thought of it, you've made the estrogen small window. Now you want to neutralize it so that the body isn't under its constant influence. So you want this metabolite, this estrogen, this hub light to have lost bind to the receptor. You want it to last. It's estrogen Ising properties. Lo and behold, four estrogen, one of those three metabolites retains the ability to bind the estrogen receptor. In fact, some studies show it might be an even more potent comm when it, when it binds and it creates this, this common, a tutorial, Leiden and receptor, it's DNA. Transcribing effects are even more potent, much like the analogy between DHT and the androgen receptor versus testosterone. DHT dihydrotestosterone, which is a metabolite of testosterone, has a higher potency binding affinity to the androgen receptor. Speaker 3: (01:03:00) Four hydroxy estrogen is to the estrogen receptor as DHT is to the androgen receptor. Wow. The ability innate tendency of a young woman when she's faced with estrogens to make either the two hydroxy which is considered protective because has lost or the four hydroxy that inmate differentiation is radically genetically determinable. Now, if something as simple as that, Lisa, when you stitch these things together, when you understand, look, estrogen should be my body needs security and rhythm. I do not want estrogen is constant. When I break down those estrogens, I want my body to have had a break from them. And you did not know whether you were four hydroxy dominant or not. If you had a tendency to make more of the four hydroxy than the two and why is four hydroxy so naughty? Three reasons. A, it binds the estrogen receptor, not giving your body a break from the estrogen ization one to four hydroxy estrogen if you are not flushing it out of the body and how do you flush out for drugs, the estrogen through methylation, the comp gene, which is catechal methyl transfers an oops. Speaker 3: (01:04:29) Can you imagine if you were innately genetic info, hydroxy dominant and have the slow comps because now you're making too much four hydroxyestrone you have a tendency to do so. You do not have the enzymatic ability to get rid of it. Now you buy your stagnate, your four hydroxy Astrid. Do you know what full hydroxy estrogen does other than binding the estrogen receptor and Quinones? Quinones? Listen, my God, you're speaking more than some of the best medical biologists that I've spoken to. So the, the decompose into Quinones and do you know what Quinones do? They get into your DNA. They stick to, they are mutagens. They stick to your DNA, causing the DNA to not be able to unravel and repair itself and by the Quinones then cause accidents. So here's what you don't want to be. You don't want to be the young woman who is genetically predisposed to overly produce four hydroxy estrogen simultaneously, have a poor comp, simultaneously, have a low GSTT one GSTP one, which was the thing, Quinones, and then have a poor mitochondrial superoxide dismutase or antioxidation to get rid of the oxidants Speaker 2: (01:05:52) And add to that. You're in your forties or your 50s and you're making more EstroZen, Speaker 3: (01:05:57) Which is a breast tissue because it's not in the liver anymore. The liver organ, at least it was designed for that type of metabolism. You're doing this in the breasts, you know, God forbid. Okay, Speaker 2: (01:06:10) This is where the cancers can come in Speaker 3: (01:06:13) This is weird and just why we have the the epidemiologic rise during that shift where the woman's body shifts from doing that grunt work in her liver, which was designed for it to doing that grunt work in such as breast tissue, cervical tissue, an ovarian tissue and so on and so forth. Which of course the human body, the female body does not express estrogen receptors, the same level for every cell type. You know, when you were, we lobby at nine years old and you could have gone outside, you know, flat chested like any other boy and you know, and then when, when men awe kits and the body changed your elbows and forms didn't change, it was suitable zone. Those are the zones that have more estrogen receptors. Speaker 2: (01:07:03) And this is so this is how we can see like when you're looking at the phenotype, if we can go look like the the the hormone cascade just for people that are listening, it's going from producer owns and pregnenolone's into testosterone's which can sometimes go into DHT and which then go into the estrogen. Is thrown in your estradiol if you're pregnant when you're older you have more strokes coming in which are, that's coming from the the other top of testosterone isn't it? One on one and then it's means a lighter than these three path rates into the two hydroxy four h

I'm constantly blown away by the amount of genetic data and actionable information one can garner from a simple bit of saliva. In today's episode, you're going to get an insider glimpse into how to go way beyond something as simple as 23AndMe or Ancestry and instead learn how to get truly useful health information that you can use to enhance health, performance, sleep, gut function, neurotransmitters and cognition and much more. My guest on this podcast, , has an extremely impressive background in the field of genetics. His credentials include: -BSc. Specialized Honours in Molecular Genetics | University of Guelph | Guelph -Doctor of Philosophy with Distinction in Molecular Genetics & Immunology | University of Guelph | Guelph -Postdoctoral Clinical Cytogenetics Fellowship | University of California | Los Angeles -Postdoctoral Clinical Cytogenetics Fellowship | Baylor College of Medicine | Houston Dr. Mansoor is now the President and CSO of The DNA Company, a leading and innovative provider of comprehensive Functional Genomics testing and consulting and an industry first: individually customized supplements based on your genetics. He is widely regarded as a pioneer in medical genomics and has been the recipient of multiple academic and industry awards. He is the holder of several patents in the general fields of molecular diagnostics and genomics research and is one of the most sought-after national and international conference speakers in the genre of personalized medicine. Prior to his role at , Dr. Mansoor was: - Founder and President of ManaGene (2010-2018) - CEO of Combimatrix (Nasdaq traded leader in diagnostic genomic microarrays) (2006-2010) - Director of Genomics at Quest Diagnostics (The world’s largest reference laboratory with a market capitalization of over $10 billion US) (2003-2006) - Director of Research and Development at Spectral Genomics (one of the industry’s first commercial genomic microarray developers spun out of Baylor College of Medicine under Dr. Mansoor’s scientific leadership) Dr. Mansoor maintains an active clinical practice as a genomics consultant to some of the leading executive health clinics in Canada and abroad. During our discussion, you'll discover: -What makes each DNA test different and how to choose what's right for you...9:30 Consider the various elements of genetic testing: SNPs (pronounce "snips"; single nucleotide polymorphisms) Copy number variation (CNV) INDEL (insertion/deletion polymorphism) Understand how the various labs go about testing the elements Humans have two identical copies of the DNA code (from each parent) When testing for SNPs, the genetic paragraph is "read" and looks for variations between the two The more paragraphs you try to query simultaneously, the greater risk of error (false negatives/positives) Characteristics of a proper DNA test: Concern is for the physical manifestation of the genes, not the genes themselves Cellular function is key indicator Identify the genes that influence the desired outcome Pinpoint the specific DNA to test vs. "shotgun" approach Avoid drawing data for data's sake -A review of Ben's DNA test and how they compare to his two sons...25:00 Two different reports: Genome Pulse Report and Hormone Pulse Report (looking at the GPR) Vascular function Cells that line the vascular system receive the most wear and tear 9P21 markers (not genes) are correlated with the lining of the blood vessels; "the heart of the human genome" A alleles and G alleles The more G alleles you have, the less resilient is the endothelial lining Increase good quality vegetable matter People with multiple G alleles benefit less from vegetable matter (like red wine) than those with none Smokers are more likely to die of vascular disease than lung disease Glutathione S-Transferase (GST) pathway is one of the key pathways in the body Glutathionization: the cellular process that neutralizes toxins in the body What happens when someone doesn't have 2 copies of a gene... You sometimes have genes you didn't inherit from either parent Talking about SNPs in the gene is irrelevant; As is epigenetics (alter the expression of the genes, not the genes itself) 3 vitally important GST genes: Theta 1, Pai 1, Nu1 Should a person only have 1 copy of a gene, they will produce 50% less than someone with 2 copies Ben Greenfield has 1 copy of the GSTT1 gene (as does 60% of the population) Important to not exceed a healthy toxicity threshold Ben Greenfield does not have the GSTM1 gene at all Useless to discuss SNPs for that gene The M1 gene is a backup: it can be lost with less consequence than other genes (such as the T1) What this means is that Ben Greenfield has low to average glutathione detox capacity Must be more cognizant of diet, environment, etc. Ben's two boys are missing the GSTT1 gene completely -Personalizing diet and/or supplements based on DNA test results...57:25 Youtrients [link] Nothing compares to an optimal diet (eating whole foods) Customized based on dietary limitations (lactose intolerance) Ethnic and geographic factors, as well as the environment during weaning, affect how to interpret test results Elites of Victorian era England adjusted their lifestyle (living in Scottish highlands in the autumn months) Reduce, not promote, supplementation, to where only necessary Our bodies are not designed to accommodate many of the supplements on the market "Is there a cellular function that is dysfunctional?" Then address that through supplementation More is not always better when it comes to genetics 3 disparate aspects of cellular function: Endothelial quality Detox capacity Insulin productivity and function in response to diet -Differences between the hormone pulse report and the genome pulse report...1:18:25 BDNF (brain-derived neurotropic factor) is one of the most important genes in our body First thing looking at: How does the body (male or female) convert progesterones into androgens, into estrogens t-intersection (4 points): How efficiently converting progesterone into androgens 3 things happen when you make testosterone: Use it Convert some of it into DHT Metabolize (glucuronidation) Ben has the perfect balance of the t-intersection Ben's boys are identical, except have a higher predisposed conversion of testosterone into estrogen -About the ACTN3 gene and its relation to exercise types...1:28:50 -And much more... Resources from this episode: - Click here for testing with Youtrients through the TheDNACompany. They offer their complete functional genomics test package for $399 USD (that’s a savings of $50 from retail price), and your test package includes both Hormone and Genome Pulse panel tests as well as a clinical report for each panel, along with full access to their webinar series, which introduces the science and interpretation of your genomic results with regards to key biological systems and processes.  - Ben's Hormone Pulse results from TheDNA Company [pdf-embedder url="/wp-content/uploads/2019/06/Ben-Greenfield-HORMONE-PULSE-REPORT.pdf" title="Ben Greenfield HORMONE PULSE REPORT"] - Ben's Genome Pulse results from TheDNA Company [pdf-embedder url="/wp-content/uploads/2019/06/Ben-Greenfield-GENOME-PULSE-REPORT.pdf" title="Ben Greenfield GENOME PULSE REPORT"] Episode sponsors: -: My personal playground for new supplement formulations. Ben Greenfield Fitness listeners receive a 10% discount off your entire order when you use discount code: BGF10. -: Contains a host of anti-inflammatory, anti-obesity, and anti-allergy benefits. For this reason, I have decided to now make consumption of hydrogen-rich water an important part of my daily nutritional routine...and I highly recommend it! Enter code: BEN at checkout and get 30% off your order! -: Halo Sport revolutionized physical training by being the first-ever product that can increase your neuroplasticity by putting your brain into a state that neuroscientists called hyperlearning. The fully upgraded Halo Sport 2 was just announced and it’s pre-selling for just $279 (less than half the price of the first model) when you use code: GREENFIELD. -: Quality is our Gimmick isn’t just our slogan, it’s a commitment we honor with every stitch we sew. 100% money back guarantee. Get 10% off your order, PLUS free shipping on any order over $99 when you use discount code: BENG. Do you have questions, thoughts or feedback for Dr. Mansoor or me? Leave your comments below and one of us will reply!  

Today we look at one of the most impressive labs I have run on myself.  Enjoy the show.  www.mikedaciuk.com 

Today we look at cutting edge labs that help you uncover which supplements, medications and lifestyle changes are best for you.  Enjoy the show.  www.mikedaciuk.com

If you read this week's article "", then you are aware that I'm not a big fan of a myopic "one-size-fits-all" approach to diets. And yet, despite the enormous amount of biochemical individuality that exists from person to person, there is still a plethora of diet books published each year (particularly close to swimsuit season or the New Year) that promise to be the de facto final solution for everything from fat loss to banishing acne to beating cravings and building muscle when, in fact, the same ketogenic diet that helped your neighbor shed twenty pounds can result in rampant inflammation, brain fog and oxidized cholesterol for you. The same could be said for a vegan diet, a carnivore diet or many of the other currently popular eating approaches. In today's podcast, Part 1 of a 2 part series on customizing your diet to you, you're going to discover more about the concept of biochemical individuality, along with how to test your body to determine the perfect diet for you, and a range of dietary options to choose from that have been vetted by yours truly. Enjoy! During this solosode discussion, you'll discover: -The concept of biochemical individuality...7:35 Book: Biochemical Individuality by Roger Williams No such thing as an "average" person. Nutrition and environment can affect our outcome. Some people do not need to supplement Vitamin C, A, Riboflavin, etc. Others are resistant to things such as Vitamin D; taking the recommended amount damages their system. What worked for someone else may be damaging for you. Ketogenic Diet I used this when racing in Ironman triathlons; I still use it for days I need endurance. Some are high in cholesterol, high liver enzymes. Familial hypercholesterolemia; negative response to high intake of fats. Low amount of Alpha-Linolenic acid (ALA) is converted into usable DHA or EPA Elongation of Omega 6 fatty acids Thrifty gene hypothesis (James Neal in 1962): Why humans build fat mass Some people possess genes that cause them to accumulate fat faster than others. FTO and PPRA genes are responsible for storing fatty acids. Consider a low fat, or plant-based diet vs. a ketogenic if you have these genes. Book: Wired to Eat by Rob Wolf -Differences in methylation between individuals...30:20 Meat eaters: most meat has high amounts of methionine, which is a high methyl donor Methylation occurs when a methyl group is taken from one compound or molecule and is transferred to another. If you're undermethylated, you would benefit from a high intake of muscular meats. Folate acts as a serotonin reuptake promoter. Good for undermethylators. Overmethylation: last thing you need is a bunch of meat for every meal. Consume protein, but don't be an extreme carnivore. -How to eat according to your ancestry...35:05 Northern European: Access to fish, Vitamin D Mexicans, Hispanics, Chinese: More folate rich foods, leafy greens. Japanese, Continental Europeans: High starch consuming Lactase persistence gene If of European descent, more likely to be lactose intolerant. Genes help determine biochemical individuality -The best types of tests to figure out what diet is right for you... Get a good blood test: Wellness FX Longevity Panel Cyrex test for food allergies Stool testing: Viome Genova Diagnostics DNA testing: Youtrients (listen to , Youtrients founder) 23 and Me Genetic Genie Use Dr. Google Urine testing: Dutch test Organic amino acids test Arresting metabolic rate test -The best diets and books I've come across over the years...44:05 Regardless of the diet you follow, follow basic practices. Auto-Immune Paleo diet Good for healing inflammation and leaky gut Specific Carbohydrate Diet Breaking the Vicious Cycle by Elaine Gottschall Gut and Psychology Syndrome Diet (GaPS) Book: Gut and Psychology Syndrome Swiss Detox Diet Colorado Cleanse Elemental Diet Book: SIBO Info Book: Healthy Gut, Healthy You by Dr. Michael Ruscio Walls Protocol Plant Paradox Diet Lower carb, lower sugar Mediterranean diet Weston A. Price Diet Closest to how I and my family eat You can customize it to your ancestry  Book: The Jungle Effect by Daphne Miller (listen to ) -And much more... Episode Sponsors: - Choose your meals. Unpack your box. Create magic. Get your first 3 meals for FREE when you order using . - Order your JOOVV light using my link and get a special bonus gift. - Quality is our Gimmick isn’t just our slogan, it’s a commitment we honor with every stitch sewn. Get 10% off your order when you use code "ben" at checkout. Free shipping for orders over $99. - Bone Broth. Support skin, join and gut health. Save 15% and get free shipping on orders of 6+ cartons when you use my link. Do you have questions, thoughts or feedback for me about customizing and personalizing your diet? Leave your comments at http://bengreenfieldfitness.com/fdiets and I will reply!

Today we look at a brand new test that can determine how you process foods, supplements and your environment around you.  Enjoy the show.  www.mikedaciuk.com

Three months ago, I and my twin ten-year-old boys sent our saliva off to a lab in Canada for one of the most advanced genetic tests available. And I was blown away by what I learned. In today's podcast, I reveal the test that we took, exactly what we learned and how you can take the same test as we did. My guest is Dr. Karim Dhanani, who is the founder and Chief Medical Director at Toronto’s Centre for Biological Medicine, a clinic that is redefining North American naturopathic medicine for the 21st century. Dr. Dhanani’s clinic – a specially designed, ecologically sound facility set in pristine Canadian woodland – has become a global mecca for those seeking to live their lives at 100%. For Dr. Dhanani, the appeal of medicine was always the investigative aspect. He loves breaking down a tough problem, and systematically uncovering the root causes with diligence, discipline, and precision. After completing his education in biology, chemistry, and naturopathic medicine, he found his calling in German biological medicine, a branch of naturopathy that integrates cutting-edge science and precision with the millennia-old wisdom of natural healing techniques. But just learning in a laboratory setting wasn’t enough. Dr. Dhanani set off on a journey that took him from Canada to Europe to Africa and beyond, to understand what lies at the most advanced frontiers of Biological Medicine. Since establishing the Centre for Biological Medicine in 2002, he has transformed the lives of thousands of individuals, including athletes, scientists, and other doctors at the highest levels of their professions. His internationally renowned reputation – particularly in the naturopathic treatment of chronic degenerative disease – has led to research collaborations with Nobel Prize winners, and turned Dr. Dhanani into one of naturopathic medicine’s most sought-after speakers. During our discussion, you'll discover: -The fascinating history and world of biological medicine, and a German pioneer of medicine that Dr. Dhanani learned from...9:15 The goal is to identify the "root cause" of a symptom or problem. It's a combination of diagnostic tools and innovative thought processes. "We look to see what 'outside the box' is influencing what is 'inside the box.'" What is the relationship between biological medicine and bioregulatory medicine? Only substantive difference is that of vernacular. Both are looking at the body's capacity to heal; responses to symptoms, or "punches" to your body. Cell communication: we believe cells speak via biochemistry. : pioneer of biophotonic signaling of cells. . Energy medicine has a larger role to play than physical medicine. -The most interesting biohacks coming out of Europe, including the Mora machine for detoxification and new types of laser treatments for red blood cells...21:55 Just like we use words to communicate, certain bodies require light and sound to communicate. The Mora machine uses electronics and sound to drive specific frequencies into the system. We can increase the amount of glutathione in your body by simply giving the frequency of glutathione without injecting it. You're providing a mechanism to carry the molecule into the body energetically. Different color lights (not LED) affects communication between cells. Depth of penetration of LED lights isn't as efficacious as lasers. -Where 23andme genetic testing falls short, and what Dr. Dhanani has discovered when it comes to the truth about genetic testing and genomics...29:18 You're only as good as the technology available.  Tests must be 1) Accurate, 2) Reproducible and 3) Functionally relevant. 23andme uses "SNIPS" which are not functionally relevant; they're good for data collection and perhaps ancestry. For illustration: You don't assume the forest is unwell because one tree in it is unwell. Look at associations of SNIPS. MTHFR is one of many we can examine. Anywhere between 15-40% error rate with consumer tests like 23andme. CNV (copy number variance) D2C tests don't tell you whether you have one or two copies of a particular gene. You get a distorted view of your level of detox. The type of genetic testing is applicable for testing for illegal substances. 23andme also doesn't test for insertion/deletion genes. -Why Ben can't absorb Vitamin D from sunlight, and why he must supplement with Vitamin D instead...52:00 Vitamin D is actually a pro-hormone, more than an actual vitamin. 125 hydroxy vitamin D is the actual component. Some people are not genetically predisposed to absorb the 125 hydroxy from sunlight; it's necessary to transport it via supplements. Thorne Vitamin D and Vitamin K. -Why Ben and his twin boys now take glutathione every day (and why you must be very careful if you use any form of injectable glutathione)...57:30 Modern technology causes pollutants and stressors on the body that didn't exist 100 years ago. We're referring to utilization and recycling of glutathione, rather than the production. Many diseases can be traced to low levels of glutathione and the inability to detoxify the body. -How to increase your body's own glutathione with nutrients such as N-Acetyl Cysteine, Alpha, Lipoic Acid, Selenium and Milk Thistle...1:03:35 The best scenario is your body generating glutathione on its own; when the gene is deleted, then you seek injections. Dr. Dhanani's lab will create a customized formula, rather than trying to ingest them individually. What is preferable: a liquid or powdered injection. Parkinson's patients have been known to have their symptoms stabilized within seconds of a glutathione IV. You get optimal results beginning with a powder, then mixing it with saline before injecting. The objection of the injection is to train your body to generate glutathione on its own. -Why Ben has high natural amounts of vascular inflammation and what that has to do with high intensity exercise and HIIT training...1:05:40 9P21 gene is a pre-ordained inflammatory level that is higher than normal. Occurs independent of diet, activity, etc. High intensity exercise creates massive amounts of blood flow, then it stops; this exacerbates the issue. Folks who are uber healthy, then die suddenly have the 9P21 gene; they've actually been tested for it. People who die from chemotherapy, have the 9P21. -How to know if your pancreas is producing the proper amount of insulin in response to the diet you are eating...1:17:30 tcf7l2 gene If I was not tracking my levels and activity, I'd be at serious risk of a heart attack given my genetics. -The DMPS/EDTA Chelation Challenge for heavy metals and how it works...1:22:15 You want to look for a spike in your aluminum; it tends to be stored in the brain. If you see that spike, you're at the deepest storage level. DMSA doesn't pull lead or cadmium out of your system. -The best way to measure your endothelial health and vascular function (using a protocol called "Endo-PAT")...1:25:30 PAT = Peripheral Arterial Tone. They measure endothelial lining, the level of inflammation. They can change over time, or with changes in your diet. Always be comparing apples to apples. -The extreme importance for Brain Derived Neurotrophic Factor (BDNF) of sauna, intermittent fasting, Lion's Mane mushroom extract, and low intensity (not HIIT) cardio...1:28:45 We associate this with TBI. Reprogram neural inputs to offset the damaged pattern. Those with 9P21 gene are more susceptible to endothelial inflammation. Limit extreme activity. The 9P21 gene limits the amount of dopamine you're naturally able to produce. -Why having a "low serotonin reabsorption" issue can cause you to ruminate and dwell upon items...1:33:15 Serotonin is the "seat" of executive function: how does your body eliminate peripheral nagging in your system? Peripheral/secondary things become your focus. Mental echo: "did I actually close the garage door???" -How Ben takes notes at night without keeping himself awake for too long...1:36:45 Evernote or similar tools that sync among devices. People with low BDNF and serotonin can actually connect things like conversations and tasks better - because you're ruminating on them. I keep a and piece of paper so I can take notes as they come into my mind. Low BDNF also affects circadian rhythm; difficulty falling and maintaining sleep. Lion's Mane mushroom extract helps supplement BDNF. -The single most important reason Ben needs to limit his intake of saturated fats...1:44:00 7-10% of fat should be saturated. You can have avocados, but not coconut or MCT oils. 9P21 gene increases inflammation; which goes to your vasculature and affects your focus and concentration. Going beyond supplements: lifestyle activities such as meditation, intermittent fasting are efficacious in increasing serotonin. -Why Dr. Dhanani says: "Epigenetics can disqualify genetics - and I’ve done just that"...1:49:40 -And much more! Resources from this episode: -Click here to get $50 off a consult with Dr. Dhanani, along with $400 (instead of $920) for the test and $199/month (instead of $229/month) for the customized supplements. - - - - -Book:  - -Book:  - - - - - - - - -Book: - - is offering podcast listeners an opportunity to take charge of their health by offering Youtrients testing and supplements at over 50% discount. Regular testing price is US$920.00, now you can take advantage of the same testing for US$400.00 Along with this, the will support your ongoing health by offering consultations to detail the results of the genomic tests to tailor your food intake, lifestyle and supplements to optimum health and wellness. With the genomic test, there is a $50 discount for this consultation, should you choose to proceed. To complete and ensure your optimal on going health, we are also offering monthly supplement subscriptions to all at a $30 discount; regular monthly fee of US$229, now only US$199 per month. These supplements are tailored to your needs, based on the showings of your Youtrients test and are fully discussed during your consultation by our doctors; however, there is no obligation to opt-in for this feature. Episode Sponsors: - The best supplement line on the Internet. Don't believe me? Just ask me, and I'll tell you! Use for support for normal blood sugar levels and healthy energy metabolism, even after large, carb-rich meals. - The Organifi Green is like a salad in your glass. Use discount code "greenfield" and get 20% off your order! - Next-Level Light Therapy. See how Joovv can help you reach—and surpass—your health and fitness goals. Order with my link and get a special gift with your order! - is what I use to eat gluten without all the negative side effects. Get 10% off your order using my link. Do you have questions, thoughts or feedback for Dr. Karim or me? Leave your comments below and one of us will reply!

In today's super special episode, Michelle interview's the Canadian-based company called Youtrients. This is a revolutionary lab who specializes in mapping out genetic pathways in order to identify our weakest links and give us tools to positively influence our health. You can learn how to use specific lifestyle, food and nutrient recommendations to enhance your executive function, like focus and mood, detox pathways, hormone pathways, and a whole lot more. It's very exciting stuff! Tune in to catch the full conversation! Hosted on Acast. See acast.com/privacy for more information.