Podcasts about syntex

We can confirm now that Microsoft will make Microsoft 365 Copilot Chat available to use for organisational accounts without an M365 Copilot license.  It will use a Pay As You Go model, just like Syntex. But the details are not complete. How much is it? Is it the whole M365 Copilot experience? How do we limit access to it? Why has this message been updated already? Actually, at the time of writing this video description... where is the message?    We talk about this and more in our first show of the year:   - Microsoft Purview | New secure workflow to bypass legal holds and retention policies   - Add a Loop workspace tab to standard Teams channels   - Microsoft 365 Copilot | Select Microsoft SharePoint sites when writing prompts   - Microsoft 365 Copilot | Select SharePoint and OneDrive folders when writing prompts   - SharePoint Pages Flexible Sections   - Updated Microsoft 365 Copilot Chat | Set up "Pay-as-you-go billing" in Microsoft 365 admin center   - Microsoft Teams | Edit your display name in meetings   Join Daniel Glenn and Darrell as a Service Webster as they cover the latest messages in the Microsoft 365 Message Center.     Check out Darrell & Daniel's own YouTube channels at:  Darrell - https://youtube.com/modernworkmentor  Daniel - https://youtube.com/DanielGlenn   

Happiest of holidays, and welcome to 2025! December 2024 brought some great new offerings: Microsoft Syntex pay-as-you-go: Simple document processing model, Viva Connections: Power Apps card, Viva Pulse now included in Microsoft 365 Copilot, Microsoft Search for Bing retirement, Outlook.cloud.microsoft, Add external content links to Viva Learning, Microsoft 365 data residency: New Zealand, the big, upcoming SharePoint Event + AMA (Jan.29.2025 - 9 AM PST), and more. Plus, a little year in review: The top five features of 2024, a quick list of apps we said goodbye to, and a few 2025 predictions.   Read this episode's corresponding blog post.   02:11 Employee engagement SPONSOR | Upcoming SharePoint event 09:36 Top 5 SharePoint features shipped in 2024 20:40 Related technology 26:29 January 2025 teasers 32:22 AI and agents insights from Jeff Teper   SharePoint | Facebook | @SharePoint | SharePoint Community Blog | Feedback  Mark Kashman |@mkashman [co-host] Microsoft Docs - The home for Microsoft documentation for end users, developers, and IT professionals. Microsoft Tech Community Home Stay on top of Office 365 changes   Upcoming events ON DEMAND Microsoft Ignite 2024 | Incl. SharePoint "event guide"  ESPC | Dec 2-5, 2024 in Stockholm, Sweden (incl. Jeff Teper's ESPC24 keynote on demand) UPCOMING "SharePoint: From Concept to Creation to Impact + Live AMA" webinar with Jeff Teper | Jan. 29, 2025, 9:00 AM - 10:00 AM PST M365 Miami 2025 | Feb.6-7.2025 MVP Summit 2025 | March 24-27.2025 (Redmond, WA & online) Microsoft 365 Community Conference | May 5-8, 2025 (Vegas) SharePoint Intranet Festival (SWOOP Analytics) | May 21, 2025 (Online) European Collabroation Summit | May 26-28, 2025 (Düsseldorf, Germany) + always review and share the CommunityDays.org website   Discover and follow other Microsoft podcasts at aka.ms/microsoft/podcasts. Follow The Intrazone at aka.ms/TheIntrazone.

Scheduling meetings is becoming a more consistent experience across Teams and New Outlook. The new Teams Calendar will inherit Outlook on the Web capabilities. And SharePoint Design Ideas is available now, beginning with text, banner and image web parts in sections. What else does this week bring?   Daniel and Darrell now share their 365 Message Center message sorting with a live audience. Join the live stream and the chat. Contribute to the show and tell us which messages are important to you and why.

FULL SHOW NOTES https://podcast.nz365guy.com/517 Discover the transformative power of AI as Gwenael Bego, Microsoft's Group Product Manager, takes us on a journey through the innovative landscapes of AI Builder and Power Automate. This episode is a treasure trove of insights for anyone eager to harness AI's capabilities without needing to write a single line of code. Gwenael isn't all work, though; he also shares the rich tapestry of his life, weaving in stories from his Hong Kong roots to his current Parisian escapades. If you're itching for authentic Parisian culture, you're in luck! Gwenael divulges those tucked-away haunts and experiences that give the City of Lights its true luster, from its pulsing nightlife to its resplendent arts scene, with a splash of champagne wisdom for good measure.Step into the future with us as we explore the synergy between AI Builder and Syntex, peeling back the curtain to reveal how these platforms are revolutionizing business workflows. You'll be at the edge of your seat as we uncover the burgeoning world of Generative AI, spotlighting the exciting potential of GPT models and their integration within familiar business tools. And because no technological advance is complete without addressing the elephant in the room, we confront the issues of data privacy and security head-on, showcasing Microsoft's relentless commitment to responsible AI. This episode is not just about learning; it's about experiencing the vision of AI as it reshapes the digital terrain.AgileXRM AgileXRm - The integrated BPM for Microsoft Power PlatformSupport the showIf you want to get in touch with me, you can message me here on Linkedin.Thanks for listening

Welcome to 2024! A few pieces of interesting news and updates from Microsoft especially around the PAYG offering with Syntex. I'm hanging out for the remaining items in the Intune suite to drop, especially third party patching so stay tuned for more information when that becomes available. Until then here' s the latest in the Microsoft Cloud. Resources @directorcia Join my shared channel CIAOPS merch store Become a CIAOPS Patron CIAOPS Blog CIAOPS Brief CIAOPSLabs Rerun queries in query history Microsoft Datacenter Tour: Virtual Experience SharePoint Roadmap Pitstop: December 2023  Enabling Microsoft Syntex PAYG Experience AI-enhanced meetings in every Teams Room Introducing a new Copilot key to kick off the year of AI-powered Windows PCs What's New in Microsoft Teams | December 2023  Get organized at work with Microsoft Loop Copilot app for iOS Copilot app for Android Financially motivated threat actors misusing App Installer  Overview of multi factor authentication 

On today's episode, we chat with Joanne Klein - an expert on compliance in Microsoft 365. Joanne brings energy and technical expertise to real-world implementations of collaboration balanced with compliance. We spoke onsite during 365 EduCon - Chicago about records management and specific tooling (like Microsoft Purview), content lifecycle management best practices, and how to get it right from the get-go.   Read this episode's corresponding blog post.   15:52 Conversation with Joanne Klein 43:43 Upcoming Events   Joanne Klein | LinkedIn | X | Website [guest] SharePoint | Facebook | @SharePoint | SharePoint Community Blog | Feedback Mark Kashman |@mkashman [co-host] Chris McNulty |@cmcnulty2000 [co-host]   Microsoft Docs - The home for Microsoft documentation for end users, developers, and IT professionals.  Microsoft Tech Community Home Stay on top of Office 365 changes   Upcoming events: Microsoft Ignite now on-demand | from Nov. 14-17, 2023 Teams Nation 2024 | Feb. 21, 2024 | #TeamsNation + early tweet Microsoft Fabric Community Conference | March 26-28, 2024 in Las Vegas, NV AIIM | April 3-5, 2024 in San Antonio, TX North American Cloud & Collaboration Summit (NACS) | April 9-11, 2024 in Dallas, TX Microosft 365 Conference | April 28 - May 4, 2024 in Orlando, FL SharePoint Intranet Festival (Online) European Collaboration Summit | May 14-16, 2024 in Weisbaden, Germany 365 EduCon - Seattle | June 3-7, 2024 in Seattle, W   Discover and follow other Microsoft podcasts at aka.ms/microsoft/podcasts Follow the Intrazone at aka.ms/TheIntrazone.

(Disclaimer: erstellt mit Chat GPT)Hallo liebe Zuhörer:Innen, Hallo liebe Community,willkommen zurück zu einer neuen Folge von "Talk Microsoft 365"! In dieser Episode lassen Michael und Thorsten den Copilot mal Copilot sein und tauchen stattdessen in eine Welt voller Microsoft Teams, Viva und SharePoint-Abenteuer ein.

In this episode, we talk with Sesha Mani, Partner Group Product Manager at Microsoft focused on security and compliance. We spoke with Sesha about SAM - that's SharePoint Advanced Management. We cover its core benefits – helping SharePoint and IT Admins address sprawl and oversharing – mapped to what it gives you beyond the core management aspects within the SharePoint admin center. SAM expands on the principles of securing and managing content and data with advanced access policies for secure content collaboration AND advanced sites content lifecycle management.   Read this episode's corresponding blog post. Plus, click here for transcript of this episode.   08:32 Conversation with Sesha Mani 39:05 Upcoming Events   Sesha Mani | LinkedIn SharePoint | Facebook | @SharePoint | SharePoint Community Blog | Feedback Mark Kashman |@MKashman [co-host] Chris McNulty |@CMcNulty2000 [co-host]   "Microsoft Syntex – SharePoint Advanced Management (SAM) Add-on – Announcing General Availability" by Sesha Mani Learn more about SharePoint Advanced Management (SAM) on Microsoft Learn Microsoft Docs - The home for Microsoft documentation for end users, developers, and IT professionals.  Microsoft Tech Community Home Stay on top of Office 365 changes   Upcoming events: 365 EduCon - Seattle (plus PWR EduCon) | Aug.21-25.2023 SEF 2023 | Sept.11-12.2023 (Tekniska Museet – Stockholm, Sweden) Microsoft Power Platform Conference | Oct.3-5.2023 (Las Vegas) CollabDays New England | Oct.5.2023 (Burlington, MA) 365 EduCon - Chicago | Oct.30 - Nov.4, 2023 (Chicago, IL) Community Days - Mexico City | Nov.2.2023 (Juarez, Ciudad de Mexico) Microsoft Ignite | Nov. 14-17, 2023 (Hybrid: Seattle, WA and online with pre-day labs) European SharePoint Conference | Nov.27-30 in (Amsterdam, Netherlands) European Cloud Summit | Dec.4-6.2023 (Wiesbaden, Germany)   Discover and follow other Microsoft podcasts at aka.ms/microsoft/podcasts.   Follow the Intrazone at aka.ms/TheIntrazone.

Welcome to another exciting episode of our podcast series. This session is a special treat for all of you as we take a nostalgic journey with my father, Ray O'Kelly. As a seasoned sales professional from the late 70s and early 80s, he spins intriguing tales from his career transition from Robbins to Syntex, a California-based company renowned for its innovative product, Naperson. Not only did he witness Naperson's rise to become the number one arthritic drug in the US and eventually worldwide, but he also experienced the gripping three-week and three-day training offered by Syntex.Buckle up folks, because we're about to dive into the evolution of sales strategies and the integration of technology in the late 70s and early 80s. The era brought a significant shift in the pharmaceutical industry to the 'pod system', a unique approach where multiple reps sold the same product, and the advent of IBM slates for call management. Life wasn't all work though! Delight in my father's recollections of unforgettable regional sales meetings, featuring luminary entertainers like Jay Leno, Huey Lewis, and James Brown. But the roller-coaster has more in store. Engage with our discussion on Roche's landmark acquisition of Syntex, a pharmaceutical company boasting 1200 reps, for a staggering $5.3 billion. We dive deep into the changing landscape of the pharmaceutical industry, the differences between copier sales and pharmaceutical sales, and the impact of this acquisition on the sales reps. To cap off our discussion, we travel back in time to the Ford Taurus redesign and the cars my father, Ray O'Kelly, drove during his illustrious career. Stay tuned for the next chapter in the O'Kelly sales lineage!Support the showTo connect with the show: Subscribe, Download & Share!Would appreciate a 5-Star Rating if deserved on Spotify & Apple Podcasts!!!Connect with Mike:Website: Mike O'KellyMike@survivingoutsidesales.comLinkedIn: Mike O'Kelly | LinkedInIG: Mike O'Kelly - Sales Builder______________________________________________________________________Are you looking to break into outside sales?I have just launched a new community for YOU!It is called Sales Entry Plan!It is a combination of group coaching, online resources & courses and live webinars on everything about "GETTING IN" to the sales role of your dreams.If interested in joining this community, click here:Sales Entry Plan ______________________________________________________________________If you are in outside sales and have had any of the following:- New to Outside Sales- New to an industry, new product, new territory - any type of change- Experienced, but have lacked training and business development- Seasoned but feel like you have hit your ceiling and need a reboot...

On the show this week - Entra ID is the new name for Azure AD and with that news it gets some new features. But should they be part of the identity suite? Microsoft 365 Copilot pricing is announced and we explore whether this is going to be value for money in a reasonably objective manner. Bing Chat Enterprise is somewhat harder to be objective about, but we try - and Syntex Backup and Archive are more interesting than may first appear. We discuss in detail. Plus great new features on the Roadmap are highlighted that will be coming to Microsoft 365 tenants soon.Want to stay up to date on all things Practical 365? Follow us on Twitter, Facebook, and Linkedin to stay up to date on all things Microsoft!

Did the FDA destroy what could have been a non-addictive pain killer that might have staved off the opioid crisis before it ever stood a chance? Several decades ago, the agency approved the drug Toradol, the first non-addictive pain killer that had pain killing effects of morphine without the addictive potential. However, the FDA set the desired peak dosage, known as the loading dose, far higher than manufacturer Syntex desired. The company reluctantly complied. 97 people prescribed Toradol dies within the first few years as a result.  With their drug no longer used in it's original form, pharmaceutical company Syntex tried to introduce the drug in an oral form. However, the FDA overcompensated for their initial error, restricting dosage to levels not useful for medicinal applications  Today's guest, Charles L. Hooper worked at Syntex when Toradol was coming onto the market as a nonsteroidal anti-inflammatory drug. This was a time of excitement for the company says Hooper. They were eager to cooperate with the FDA for a successful launch. What went wrong? Hooper discusses how a decision on something like the “loading dose” can come down to a single person, and people are fallible. The FDA's position of final the final say had disastrous consequences, leading credence to the position that they should act as a “guiding agency. Even with all the FDA's power and authority, nothing is a certainty. On April 19, 2023, when asked about the opioid crisis, FDA Commissioner Robert Califf told the Senate Appropriations subcommittee it would help if pharma could develop a “non-addictive” pain medicine. “It is a tough job, but we are not successful in having nonaddictive pain medicines coming through the pipeline. We need to do everything we can do to push industry and make this happen.” Learn more here: FDA Commissioner Called Out for Remark on Non-Addictive PainkillersRead Charles Hooper's article in the Wall Street Journal for more: How the FDA Helped Fuel the Opioid Epidemic

Did the FDA destroy what could have been a non-addictive pain killer that might have staved off the opioid crisis before it ever stood a chance? Several decades ago, the agency approved the drug Toradol, the first non-addictive pain killer that had pain killing effects of morphine without the addictive potential. However, the FDA set the desired peak dosage, known as the loading dose, far higher than manufacturer Syntex desired. The company reluctantly complied. 97 people prescribed Toradol dies within the first few years as a result.  With their drug no longer used in it's original form, pharmaceutical company Syntex tried to introduce the drug in an oral form. However, the FDA overcompensated for their initial error, restricting dosage to levels not useful for medicinal applications  Today's guest, Charles L. Hooper worked at Syntex when Toradol was coming onto the market as a nonsteroidal anti-inflammatory drug. This was a time of excitement for the company says Hooper. They were eager to cooperate with the FDA for a successful launch. What went wrong? Hooper discusses how a decision on something like the “loading dose” can come down to a single person, and people are fallible. The FDA's position of final the final say had disastrous consequences, leading credence to the position that they should act as a “guiding agency. Even with all the FDA's power and authority, nothing is a certainty. On April 19, 2023, when asked about the opioid crisis, FDA Commissioner Robert Califf told the Senate Appropriations subcommittee it would help if pharma could develop a “non-addictive” pain medicine. “It is a tough job, but we are not successful in having nonaddictive pain medicines coming through the pipeline. We need to do everything we can do to push industry and make this happen.” Learn more here: FDA Commissioner Called Out for Remark on Non-Addictive PainkillersRead Charles Hooper's article in the Wall Street Journal for more: How the FDA Helped Fuel the Opioid Epidemic

https://www.youtube.com/embed/5_a5fzQbMMw

For this episode, I spoke with Sean McDonough (@spmcdonough), a consultant at Bitstream Foundry LLC and Microsoft MVP, and Geoff Varosky (@gvaro), a senior architect at Insight, about the latest Microsoft Planner, Syntex, and Fabric updates, and other community news. You can find more information on my guest on my blog at https://www.buckleyplanet.com/2023/07/collabtalk-podcast-episode-85-with-sean-mcdonough-and-geoff-varosky.html

June had wonderful new offerings for SharePoint and Microsoft 365: New Stream (on SharePoint) web part, Playlist view in the SharePoint List  web part, Viva Connections supports different audiences, OneDrive Home update, Loop Components sync with Planner and To Do, get ready for Microsoft 365 Copilot, and more. We also added a sneak peek of Sync Up - The OneDrive podcast (it's back!). And pulled audio of Jason Moore (VP of Lists and OneDrive) to frame the essence of OneDrive and the new Home experience. Stay to the end for a bonus snippet of the conversation between Jeff Teper and his manager Rajesh Jha - where they talk about the early days and decisions evolving BPOS > Office 365 > Microsoft 365.   Read this episode's corresponding blog post. Plus, click here for transcript of this episode.   03:18 Sync Up podcast snippet with Stephen Rice and Arvind Mishra 04:33 Employee Engagement 09:30 Jason Moore on OneDrive innovation 13:17 Teamwork 16:15 Related Technology 21:42 Teasers 23:08 Jeff Teper and Rajesh Jha (Fireside chat on Office 365 customer journey)   SharePoint | Facebook | @SharePoint | SharePoint Community Blog | Feedback OneDrive | Website | Help and learning | @OneDrive | OneDrive community blog | Feedback Mark Kashman |@mkashman [co-host] Chris McNulty |@cmcnulty2000 [co-host]   Sync Up - The OneDrive podcast with Stephen Rice and Arvind Mishra Microsoft Docs - The home for Microsoft documentation for end users, developers, and IT professionals.  Microsoft Tech Community Home Stay on top of Office 365 changes   Upcoming events: Microsoft Inspire (Partner event) | July.18-19.2023 (virtual only) 365 EduCon - Seattle (plus PWR EduCon) | Aug.21-25.2023 Microsoft Power Platform Conference | Oct.3-5.2023 (Las Vegas) 365 EduCon - Chicago | Oct.30 - Nov.4, 2023 (Chicago, IL) European SharePoint Conference | Nov.27-30 in (Amsterdam, Netherlands) European Cloud Summit | Dec.4-6.2023 (Wiesbaden, Germany)   Discover and follow other Microsoft podcasts at aka.ms/microsoft/podcasts.   Follow the Intrazone at aka.ms/TheIntrazone.

Ever wonder what makes the world of Texas drag racing tick, especially the nostalgia Modified Production class? Strap in as we drift into this high-octane universe with our guests extraordinaire, the Rollo brothers, Gary and Larry. These speed aficionados guide us through the unique requirements of this class, where only cars 30 years and older are allowed to compete, and manual shifting without electronic assistance is the rule of the day. We discuss everything from the wide range of vehicles involved - think early Camaros, Corvettes, Volkswagens, and Fords - to the types of transmissions permitted. And the cherry on top? The Rollo brothers' passionate plea to save the stick shift!In our feature segment, we review the 2024 Kia Seltos SX. This all-wheel drive beast offers five trim levels, LED lighting, acoustic glass windshields, power side mirrors, and much more. And that's just the exterior. Inside, expect Syntex seating surfaces, heated front seats, a 10.25 inch driver supervision cluster, and a massive center stack info screen. There is also the 8-speaker Bose audio system, dual-level cargo floor, multiple USB ports, and a wireless charger. And under the hood? A 1.6 liter turbo engine with 195 horsepower, delivering an economically appealing EPA rating of 25/26/27 for city/highway/combined. So whether you're a drag racing enthusiast or a Kia fan, this episode has almost something for everyone.---- ----- Want more In Wheel Time Car Talk any time? In Wheel Time Car Talk is now available on iHeart Radio! Just go to iheart.com/InWheelTimeCarTalk where ever you are.----- -----Be sure to subscribe on your favorite podcast provider for the next episode of In Wheel Time Car Talk and check out our live broadcast every Saturday, 8a-11aCT simulcasting on iHeart Radio, YouTube, Facebook, Twitter, Twitch and InWheelTime.com.In Wheel Time Car Talk can be heard on you mobile device from providers such as:Apple Podcasts, Pandora Podcast, Amazon Music Podcast, Spotify, Google Podcasts, Stitcher, iHeart Radio podcast, TuneIn + Alexa, Podcast Addict, Castro, Castbox and more on your mobile device.Follow InWheelTime.com for the latest updates!Twitter: https://twitter.com/InWheelTimeInstagram: https://www.instagram.com/inwheeltime/https://www.iheart.com/live/in-wheel-time-car-talk-9327/https://www.youtube.com/inwheeltimehttps://www.Facebook.com/InWheelTimeFor more information about In Wheel Time Car Talk, email us at info@inwheeltime.comTags: In Wheel Time, automotive car talk show, car talk, Live car talk show, In Wheel Time Car Talk

Jeremy catches up with Reid Carlberg and Marc Windle about Syntex Repository Services. They discuss this new offering currently in Private Preview that was announced at Build 2023 in May.   The official announcement Introducing Syntex repository services: Microsoft 365 superpowers for your app To learn more, please visit the Syntex repository services preview page and sign up.

https://www.youtube.com/embed/aXiCeamZ9Sc

May 2023 brought great new offerings to SharePoint and Microsoft 365: Customizable Viva Connections mobile dashboard, Syntex image tagger, Syntex prebuilt model for contracts, OneDrive: Simplified sharing, Loop components in Outlook Mobile, and more.  We also highlight public disclosures from two recent events, Microsoft 365 Conference and Microsoft Build. We also share an audio clip of Rajesh Jha, EVP for experiences and devices at Microsoft, when he spoke recently at the Microsoft 365 Conference about his first time seeing ChatGPT 4 with Bill Gates, Sam Brockman from OpenAI and others - that initial wow impact that laid the foundation for Copilot innovation at Microsoft.   Read this episode's corresponding blog post and transcript.   01:15 Two upcoming June events: 1) Viva Round the World, and 2) AMA - SharePoint, OneDrive, Lists, and Stream 04:30 Employee engagement 08:53 Audio snippet of Rajesh Jha about ChatGPT and AI (from the Microsoft 365 Conference keynote) 11:35 Teamwork 13:51 Related items 18:58 Announcements from Microsoft 365 Conference and Microsoft Build) 26:35 Teasers   SharePoint | Facebook | @SharePoint | SharePoint Community Blog | Feedback Mark Kashman |@mkashman [co-host] Chris McNulty |@cmcnulty2000 [co-host]   “Welcome to the new era of SharePoint and OneDrive in Microsoft 365” by Jeff Teper. “SharePoint in the AI Era: Introducing 'Copilot in SharePoint' and 10 more innovations for creators” by Adam Harmetz. “Experience the New OneDrive: Fast, Organized, and Personalized” by Jason Moore. “Microsoft Lists: Easier, Better, Faster, Stronger” by Lincoln DeMaris. “Enhanced Video in Microsoft 365” by Owen Paulus. “New era in content management and security in SharePoint, OneDrive, and Teams” by Sesha Mani. Microsoft Build "Book of News" (May 23, 2023) Microsoft Docs - The home for Microsoft documentation for end users, developers, and IT professionals.  Microsoft Tech Community Home Stay on top of Office 365 changes   Upcoming events: Viva Round the World | June.2.2023 CollabDays Netherlands | June.10.2023 Vianen, Utrecht 365 EduCon - DC | June.12-16 Washington D.C. - USA AMA | SharePoint, OneDrive, Lists, and Stream | June.14.2023 at 10am PT (90 minutes) CollabDays - Central Europe | June.17.2023 Technopark Zuerich European Power Platform Conference | Jun.20-22 Dublin, Ireland Microsoft Inspire (Partner event) | July.18-19.2023 (virtual only) 365 EduCon - Seattle (plus 365 PWRCon) | Aug.21-25.2023   Discover and follow other Microsoft podcasts at aka.ms/microsoft/podcasts.   Follow the Intrazone at aka.ms/TheIntrazone.

On the show this week, find out what's happening with recent changes to Exchange Online that might cause a delay if you're setting up a fresh Hybrid environment; plus security recommendations for your on-premises Exchange environment. If you're getting into Viva Sales, we discuss what the new OpenAI GPT add-in does. Creepy or useful - you decide! Plus Microsoft Syntex's PAYG model goes live and Teams gets user experience changes that your users will certainly notice.Want to stay up to date on all things Practical 365? Follow us on Twitter, Facebook, and Linkedin to stay up to date on all things Microsoft!

In this episode, we cover: Yammer > Engage rebrand, Viva Topics in Viva Engage, Stream Playlists, SharePoint Advanced Management, updated OneDrive Home and Shared, external file requests for SharePoint document libraries, export Microsoft Lists as datasets for Power BI, update to rules email notifications, and more. Plus, we talk with Sesha Mani, Principal group product manager on the SharePoint team focused on admin, security, and compliance. Sesha highlights the value of new SharePoint Advanced Management capabilities when working with proposals, contracts, invoices, and more - to help IT address sprawl and oversharing with a new set of advanced security and content management capabilities - broadly speaking advanced access policies for secure content collaboration AND advanced sites content lifecycle management. Read this episode's corresponding blog post. Click here for full transcript.  1:30 Employee Engagement 7:40 Conversation with Sesha Mani 21:10 Teamwork 28:25 Related Technology   Sesha Mani | LinkedIn | Twitter SharePoint | Facebook | @SharePoint | SharePoint Community Blog | Feedback Mark Kashman |@mkashman [co-host] Chris McNulty |@cmcnulty2000 [co-host]   "Microsoft Syntex – SharePoint Advanced Management (SAM) Add-on – Announcing General Availability" (blog post) Learn more about SharePoint Advanced Management (MS Learn) Microsoft Docs - The home for Microsoft documentation for end users, developers, and IT professionals.  Microsoft Tech Community Home Stay on top of Office 365 changes   Upcoming events: Modern Workplace Conference 2023 | March.27-29.2023 Paris, France Culturati | Apr.2-3.2023 Austin, Texas Microsoft 365 Conference | May.2-4.2023 Las Vegas, Nevada CollabDays Poland | May.13.2023 Warsaw, Poland Technorama Belgium - the Jungle Edition | May.15-17 Kinepolis Antwerp Power Automate & Power Apps Developer Bootcamp Automation Summit 2023 | May.19-20.2023 London, Paddington CollabDays Italy | May.20.2023 Milan, Italy European Collaboration Summit | May.22-24.2023 Dusseldorf, Germany   Listen and follow other Microsoft podcasts at aka.ms/microsoft/podcasts. Follow the Intrazone at aka.ms/TheIntrazone.

We hear about the age of discovery of hormones and antibiotics, from the 1930s to the 1950s. Russell Marker left Penn State to find a plant from which to synthesize progesterone, so we learn about the trials and tribulations of the Mexican firm Syntex. Carl Djerassi joined Syntex and invented norethindrone. We learn of more fungal- and bacterial-based antibiotics, from streptomycin to tetracyclines, vancomycin, and methicillin--and what MRSA is.Support the show Support my podcast at https://www.patreon.com/thehistoryofchemistry Tell me how your life relates to chemistry! E-mail me at steve@historyofchem.com Get my book, O Mg! How Chemistry Came to Be, from World Scientific Publishing, https://www.worldscientific.com/worldscibooks/10.1142/12670#t=aboutBook

https://www.youtube.com/embed/uHeAtGwKBb8

In this episode, you'll hear about all the new features and updates: Microsoft Feed, Planner integration with Viva Goals, extracting PDFs in OneDrive for Android, Microsoft Lists: Calendar week layout, Microsoft Teams @Everyone, Microsoft named a Leader in 2022 Gartner® Magic Quadrant™ for Insight Engines, Stream (Classic) sets to retire: February 15, 2024, and more. Plus, we talk with Bill Bär from the 'content AI' team focused on Search, Syntex, and a whole lot of AI. Bill shares insights into the design and value of Microsoft Feed - a smart aggregate of all sorts of things happening around - content, people, videos, reminders, actionable tasks, and more -- coming to Outlook and the Office mobile apps. Read this episode's corresponding blog post. Plus, click here for transcript of this episode. Bill Bär | LinkedIn | Twitter SharePoint Facebook | @SharePoint | SharePoint Community Blog | UserVoice Mark Kashman |@mkashman [co-host] Chris McNulty |@cmcnulty2000 [co-host] Learn about Outlook mobile search, aka - Microsoft Feed in Outlook Deploying Outlook for iOS and Android app config in Exchange Download your own complimentary copy of the 2022 Gartner Magic Quadrant for Insight Engines. Make Your Goals a Reality with OKRs and New Capabilities from Microsoft Viva Goals Panel discussion at #ESPC22 w/Jeff Teper & Suzy Dean (AddIn365): https://youtu.be/gmltQ85QM54 Timeline for Stream (Classic) retirement:  https://aka.ms/StreamClassicRetireTimeline Microsoft Docs - The home for Microsoft documentation for end users, developers, and IT professionals.  Microsoft Tech Community Home Stay on top of Office 365 changes Upcoming 2023 events: Collab365 | Three-hour Microsoft Lists workshop online with Mark Kashman Reimagine Education | Feb.9.2023 (online) WorkPlaceDudes Summit | Feb.24.2023 Holland Modern Workplace Conference 2023 | March.27-29.2023 Paris, France Culturati | Apr.2-3.2023 Austin, Texas Microsoft 365 Conference | May.2-4.2023 Las Vegas, Nevada CollabDays Poland | May.13.2023 Warsaw, Poland Technorama Belgium - the Jungle Edition | May.15-17 Kinepolis Antwerp Power Automate & Power Apps Developer Bootcamp Automation Summit 2023 | May.19-20.2023 London, Paddington CollabDays Italy | May.20.2023 Milan, Italy European Collaboration Summit | May.22-24.2023 Dusseldorf, Germany Listen and follow other Microsoft podcasts at aka.ms/microsoft/podcasts. Follow the Intrazone at aka.ms/TheIntrazone.

Welcome to 2023! I have news and update from Microsoft including previews of Syntex and Teams Premium. I'll also give you an overview of what I consider essential in any Microsoft 365 tenant, Defender for Cloud Apps. Also, let me know what I should for my upcoming episode 300? Ask Me Anything? Love to hear! his episode was recorded using Microsoft Teams and produced with Camtasia 2022. Brought to you by www.ciaopspatron.com Resources @directorcia @directorcia@twit.social Join my shared channel CIAOPS merch store Become a CIAOPS Patron CIAOPS Blog YouTube edition of this podcast Azure Storage Mover–A managed migration service for Azure Storage  Attack Simulation Training: New insights into targeted user behavior  Manage your multi-cloud identity infrastructure with Microsoft Entra Disconnected environments, proxies and Microsoft Defender for Endpoint What's New in Microsoft Teams | December 2022 SharePoint Roadmap Pitstop: December 2022 Cloud App Discovery/Security What are the differences in discovery capabilities for Microsoft Defender for Cloud Apps and Cloud App Discovery? Get started with Microsoft Defender for Cloud Apps  

Our team spent most of December 2022 refining the cloud, improving it for your return to work – whenever that may be. In this episode, you'll find details about a load of great new offerings: Microsoft Syntex Pay-as-you-go (Preview), search video transcript for Stream (on SharePoint), SharePoint Apps: Add to teams when enabling an app, OneDrive: Sensitivity labels appear on the sharing dialog, OneDrive sync reports (GA), SharePoint sites search in usage analytics, Microsoft Teams Premium (Preview), Microsoft Whiteboard mobile apps, and more. Plus, we included audio from my co-host Chris McNulty, Director of product marketing for Syntex and Viva Topics – from his recent keynote segment during the European SharePoint Conference - to provide an update on all things Microsoft Syntex. Happy holidays, and welcome to 2023. Click here for this episode's corresponding blog post. Click here for transcript of this episode. Mark Kashman |@mkashman [co-host] Chris McNulty |@cmcnulty2000 [co-host] SharePoint Facebook | @SharePoint | SharePoint Community Blog | Feedback Microsoft 365 Setup site (Getting started and deployment guides) Microsoft Docs - The home for Microsoft documentation for end users, developers, and IT professionals.  Microsoft Tech Community Home Stay on top of Office 365 changes Discover and follow other Microsoft podcasts at aka.ms/microsoft/podcasts Follow The Intrazone at aka.ms/TheIntrazone

Vandaag hebben we het over SharePoint Syntex, wat je gratis kan proberen deze maand onder de PAYG licentie. Verder hebben we het over Azure container apps en wat kleine M365 nieuwtjes. Presentatie: Barbara Forbes & Jos van Schouten Productie / edit: Nils Bloem Powered by OGD ict-diensten https://www.ogd.nl/ Benieuwd naar werken bij OGD? https://werkenbij.ogd.nl/ Syntex: https://www.microsoft.com/en-us/microsoft-365/roadmap?rtc=1&searchterms=101512%2c&filters=&searchterms=101512%2C https://learn.microsoft.com/en-us/microsoft-365/contentunderstanding/syntex-overview Azure container apps: https://azure.microsoft.com/en-us/updates/public-preview-build-and-deploy-to-azure-container-apps-without-a-dockerfile-from-the-azure-cli/ Teams stale meetings: https://office365itpros.com/2022/07/13/stale-teams-meetings/ Yammer stories: https://office365itpros.com/2022/11/18/yammer-stories/

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Carl Djerassi (1923–2014), published by Gavin on November 29, 2022 on The Effective Altruism Forum. Carl Djerassi helped invent the synthetic hormone norethindrone, one of the 500 most important medicines (actually top 50 by prescription count). A large supply is a basic requirement of every health system in the world. Norethindrone is important for two reasons. First, it treats menstrual disorders and endometriosis, together 0.3% of the global burden of disease. More famously, it was a component of The Pill. People mix up the timelines, which is why he is sometimes called the 'Father of the Pill'. But "neither Djerassi nor the company he works for, Syntex, had any interest in testing it as a contraceptive" and it was only used for birth control 12 years after. As usual in industrial chemistry, Djerassi got no royalties from the blockbuster medicine he helped develop - but, surprise ending! - he bought cheap shares in Syntex and got rich when it became one of the most important medicines in history for two reasons. He also synthesized the third-ever practical antihistamine, and applied new instruments in 1,200 papers on the structure of many important steroids. He also worked on one of the first AI programs to do useful work in science. Achievements Epistemic status: little better than a guess. Not many inventions are fully counterfactual; most simple, massively profitable things which get invented would have been invented by someone else a bit later. So the appropriate unit for lauding inventors is years saved. And if I put a number on that I'd just be making it up. Here are the numbers I made up: About 4 million US users, so maybe up to 94 million world users at present. No sense of the endometriosis / contraception split. Call it 600 million users, 10% endometriosis use case. For menstrual disorders: on the market 65 years and counting. Counterfactual: on the market 3 years before the next oral progestogen was. It was the first practical oral progestogen, so we should compare to the injectable alternatives About 1/6 of Americans hate needles so much that they refuse treatment. Attrition and missed doses for needle treatments is higher than pill treatments. Endometriosis is about 0.25 - 0.35 QALY loss. So if it's 30% effective, around $30 / QALY, an amazing deal. For easy contraception: on the market 59 years and counting. The big gains (besides autonomy) are averting unintended pregnancies, abortions, and pregnancy-related deaths. Modern cost-effectiveness in Ethiopia is $96 / QALY. There's probably some additive effect for endometriosis sufferers (who would want contraception anyway). A full account would guess the Pill's effect on the sexual revolution and cultural attitudes toward women. But I've reached my limit. (You might also consider the role of the Pill in the ongoing decline of church authority: "1980: In spite of the Pope's ruling against the Pill and birth control, almost 80% of American Catholic women use contraceptives, and only 29% of American priests believe it is intrinsically immoral.") How many years did he bring the invention forward? Call it 5. Then split the credit three ways with Luis Miramontes and George Rosenkranz. So (largely made-up numbers) it looks like millions of QALYs for the treatment overall, and tens of thousands counterfactually for Djerassi. Artist After surviving cancer, he decided to become a writer. I was very depressed, and for the first time thought about mortality. Strangely enough I had not thought about death before... I realized that who knows how long I would live? In cancer they always talk about five years: if one can survive five years then presumably the cancer had been extirpated. And I thought: gee, had I known five years earlier that I would come down with cancer, would I have led a different life during these...

On this episode, we hear from Gaia Carini and Katy Erlandson from the OneDrive engineering team. We dig into OneDrive to distinguish the value between the "Add to OneDrive" feature and general sync of team site document libraries - sometimes referred to as "Shared libraries". You'll hear more about what each capability does, the path forward by design to make it easy for you, plus guidance for today and going forward. The whole of this episode spawned from a Twitter thread request, and we think you'll like this audible response. Click here for this episode's corresponding blog post. Full transcript below. Gaia Carini (Principal GPM) | Twitter | LinkedIn  Katy Erlandson (Senior product manager) | LinkedIn Mark Kashman |@mkashman [co-host] Chris McNulty |@cmcnulty2000 [co-host] OneDrive | Website | Help and learning | @OneDrive | OneDrive community blog | Feedback SharePoint Facebook | @SharePoint | SharePoint community blog | Feedback Resources: The @RippedOrange tweet thread that started it all: "Sync vs Add Shortcut to OneDrive" "Add shortcuts to shared folders in OneDrive for work or school" (support article) Microsoft Docs - The home for Microsoft documentation for end users, developers, and IT professionals.  Microsoft Tech Community Home Stay on top of Office 365 changes Discover and follow other Microsoft podcasts at aka.ms/microsoft/podcasts Upcoming Events: European SharePoint Conference 2022 (Nov.28 - Dec. 1) Copenhagen, Denmark at the Bella Center Microsoft 365 Conference (Dec.6-8.2022) Las Vegas, NV Follow The Intrazone at aka.ms/TheIntrazone   TRANSCRIPT MARK KASHMAN: Welcome to the Intrazone, a show about the Microsoft 365 Intelligent Intranet. I'm Mark Kashman, Senior Product Manager on the Microsoft 365 marketing team. And on today's episode, we hear from Gaia Carini, Principal Group Product Manager, and Katy Erlandson, Senior Product Manager, both from the OneDrive engineering team, here to dig in to distinguish the value between Add to OneDrive, the feature, and general sync of Teams Site Document Libraries.   There's a lot that you can do, and there's some best practices. And just so you know, document libraries in this case are sometimes referred to as shared libraries, those that you share with your, or in a shared space, effectively outside of your OneDrive, your own personal work OneDrive, but you want to bring in all of those files and folders even if they're shared.   So you're going to hear about each of these capabilities, the Add to OneDrive and the common notion of sync, and the path forward—by design—to make it easier for you and pervasive. You'll hear guidance today and going forward, plus a few favorite tips and tricks—direct from the team—that designs the overall user experience of OneDrive. And the of the whole of this episode kicked off by request from our audience on a unique platform discussion, and we will share that as we kick off the episode with Gaia and Katy. Just a fun way where we heard some great feedback that turned into a great episode.   So I just have a few thoughts to share. When you actually think about the Add to OneDrive feature, it's really easy. You just locate the folder that you want to add to your OneDrive, select the circle of the Folders tile, so that you can take an action on it, and then select Add Shortcut to My Files—effectively Add to OneDrive at the top of the menu—or you just right-click a folder and select that same notion, Add Shortcut to My Files.   So this is a feature that I use, the Add to OneDrive, for all of the files in this podcast, really forever – for wherever I am in my OneDrive. Most commonly, here at my desk at home, I go into the Windows Explorer, I find the Mark-Microsoft OneDrive icon, I click into the Documents-The Intrazone folder, and there it is, even though this comes from a document library in a SharePoint site that's connected to a Teams' team that we use to help manage this podcast. It's really just a one-or-two-click-away action for me to get to those show notes and the folders, and all of the things we do per each episode across the various Microsoft Teams channel, effectively a folder in a document library.   I have access to all of that. No matter where I look across OneDrive, once I've added it to OneDrive, created that shortcut for my common My Files experience, and it takes me to wherever those files are located, without moving them, but it's a great reference with some real ease of access.   So I do this for the Intrazone, I do it for the Microsoft Lists product management that I help manage here at Microsoft, and of course with various conferences, some of which are managed by other people, which I think is one of the best possible use cases where somebody else is managing files and folders, and I go in and I add those that are most relevant to me, during that event, to my OneDrive, by just clicking on their folders and files and add to my OneDrive.   I have access, so I can do that, and then I will have access, more directly, without having to navigate to that site or that team. It's just right there in Windows Explorer, same experience, document/name of event, even if it's managed by somebody else who's invited me into that team, and then we all work on a variety of files, but then I have access to all of that, with fewer clicks and more in my own domain so I know which files are mine and which files are coming from a shared location.   That's a little bit of how it works, how I use it. I think the best thing, though, is to get clarity of what we're really here to answer, which is, how do I distinguish that Add to OneDrive feature with Team Site sync when I'm using OneDrive? And no better people to help answer that than from the product team, so let's bring in Gaia and Katy to address this and much more.   (Music.)   All right, it is enough of you hearing Chris and I speculating what this OneDrive sync and all the things you can do in this modern era of files experiences everywhere. We are here talking with Gaia and Katy from the OneDrive team, joining us on the Intrazone. Gaia and Katy, welcome.   GAIA CARINI: Thanks, Mark, we're excited to be here.   MARK KASHMAN: And I'm excited that you're here. Before we get into the why we're here, which might be obvious to everybody, but we have a really particular reason that's kind of a fun reason of the way this episode came about. But if you don't mind, both of you sharing just a little bit about what you do on the OneDrive team, and of course there – if there's more that you do here at Microsoft, people would love to know a little bit more about you.   So I thought, Katy, we would start with you.   KATY ERLANDSON: I'm a PM on the OneDrive sync team. I've been working primarily on our enterprise features, the last few years, and Add to OneDrive being one of them, so I'm happy to be here today and talk more about that.   MARK KASHMAN: Very nice, and Gaia.   GAIA CARINI: Hi, everyone. I'm Gaia. I am the Group Product Manager of the OneDrive sync team. So my team, including Katy, works on OneDrive for Windows and macOS across consumer and commercial users and scenarios. And yeah, I've been working on sync for several years now, and I love being on the OneDrive team, and it's been really fun.   MARK KASHMAN: What I thought was fun about this episode, I know you both know, but for our audience, you should know that the impetus of this episode truly came from our audience in the broadest way. There was a Twitter discussion that was going on, and the focus of that was "when do I use the Add to OneDrive feature versus sync?"   And of course, you can imagine somebody out there was thinking about who they should pull into this conversation, and we now have Gaia and Katy who are about as close to the source of answering that question, which we will address it in the exact way that you'd imagine, the OneDrive team as the accurate way.   You know, when you first saw that Twitter discussion, there was that twee threat. A. I was really happy that you said yes to joining us on the Intrazone to provide the answer. Is that a common thing that you see people asking, or as they're trying to navigate some of the feature sets and capabilities of OneDrive?   GAIA CARINI: Yeah, it is a question that we have been getting, and so I was looking forward to us coming here on the Intrazone to talk more about the two different ways to sync files from either shared libraries in SharePoint, or just a folder someone has shared with you in – from their OneDrive, or files from Teams. Since it is a common question, we're really excited to go more into the differences and what our recommendations are, and what we see the long-term plan to be.   MARK KASHMAN: So where do we start? We come off this thread and we start to stare at – you know, what is a great way to answer that, which I know you both have some nice thoughts around that. I thought Gaia, just to start with you, let's set some ground foundational elements of, when we talk about sync, maybe at the Teams Site level, you know, what is that, syncing the Teams Site and then answering in that same vein of thought, what is Add to OneDrive.   GAIA CARINI: So first, starting with just OneDrive sync as the app, OneDrive sync lets you access and edit and share files from Windows and macOS, no matter where they are, in your own OneDrive, in someone else's OneDrive or in a Teams Site, you know, or in – you know, from a channel in Teams, including if you are offline. And to sync the files that are in those shared locations, we have two models that are supported, the sync button and Add to OneDrive.   And so first, I thought I'd just share what are some of the differences between those. So the sync button is something that we've had since we started supporting with the new sync client when we were on our journey to replace Groove. We added the sync button and that syncs the folder or library to that specific device.   And so let's say I'm here on my Windows PC, and I go to, you know, our team, the folder where our team saves all of our specs. I can click the sync button and that will sync it to this PC specifically. But then if I go on my Mac, I won't see that same folder, and that's where Add to OneDrive comes in.   Add to OneDrive allows you to add that folder—let's say in this case a spec folder that's really important and I go to all the time—to your OneDrive so that it's easy to find, no matter which device you're on. And it'll start syncing, you know, on that device where you added it to your OneDrive but across all your devices too.   So now, if I go back to my Mac, I'll see that same folder also being synced, but I'll also see it on my mobile device, through the OneDrive mobile app, or on Teams if I go navigate my OneDrive files through Teams, and on the web and in Office. And so it just allows you to easily find your files in those shared locations.   MARK KASHMAN: So I've used the Add to OneDrive feature, and I – I've done it four or five times, consistently, with – the right use case—at least for me—is when I go into my Windows machine, any Windows machine and I get into my OneDrive, and I see those shared folders that I've added to my OneDrive. It's the quickest way for me to get to them, and it also is the kind of spaces that I work in, pretty much throughout the year.   I have one Add to OneDrive for my next-gen events site, so any event that I work on, I can get into the folder of the individual event, see the sessions, PowerPoints, any videos, and you know, some of the pre-material that we have for people to use for like graphics to tweet out, and stuff like that.   And I also have another one that I use for Microsoft Lists, with the Lists team. It's a place where we create a lot of different outbound presentations. We also manage, you know, the different feature sets that are upcoming, but from a content and document perspective, I just go into my Windows Explorer, click on OneDrive and then go right into the name of that team, which is either Microsoft Lists or Next-gen Events, and it's just right there, and it's – it's really easy to navigate.   I know it's there, and it just – like you said, it doesn't matter which machine I'm on, so I really do love that feature, and I think it's really important for people to understand how to leverage that in the different scenarios, which I thought, Katy, if we could get some of that insight from you, you know, whether you're thinking about sync or Add to OneDrive, or what we know, kind of into the future, what we'll get to, is what do you recommend and why, when – when you think about different ways that you would guide people to use the technology.   KATY ERLANDSON: Yeah, so we definitely recommend Add to OneDrive. It is a newer, shiny feature. From Team Site sync, as Gaia mentioned, it's kind of a more holistic OneDrive experience, so you're not just getting it on whichever device you chose to sync it on, but you're getting that content across all of your devices. And it's also more – more performant. I'm not sure how many people realize this, but with Team Site sync, we're actually also syncing all of the metadata for the whole library, even if you go and you only sync at the subfolder level, like in Gaia's case in the spec folder.   In Add to OneDrive, if you go and you add the shortcut right at the spec folder level, then we're only syncing that content. So for really, really big document libraries, this can actually be a pretty big gamechanger.   GAIA CARINI: Yeah, to add to what Katy was saying, with Add to OneDrive, we've also made several improvements to the experience where, for example, if you decide, you know, you're done with a certain project and you no longer need that folder, and so you remove the shortcut from your OneDrive, we'll go and clean that up from the device, which I know is feedback we get from the sync button experience.   So we've made improvements like that to the experience. We also have a group policy that allows removing the shortcut content if users no longer have access, for example, to the content. So we've been continuing to improve on the experience, based on feedback, in addition to all of the advantages Katy mentioned.   MARK KASHMAN: Maybe, Kattie, back to you, you – you know, thoughts around guidance. If I'm IT, and I'm thinking Microsoft is describing, you know, these different ways that I can configure for my employees, my end user, what would be some of the things that we might guide them to consider—if not even pass along—to their end user?   KATY ERLANDSON: If you know that no one in your company right now is using Teams Site sync, we recommend just guiding everybody to only using Add to OneDrive. In our documentation there is a script where you can actually turn off the sync button for your whole site, and so if you know that – that no one in your – in your organization is using Teams Site sync, I would just go ahead and turn that off now and start taking advantage of – of all the things that Add to OneDrive has to offer.   If you are in a mixed state, I would definitely stay tuned for our guidance here. We will be migrating users off of Teams Site sync and into – on to Add to OneDrive, eventually, but first, we really want to make sure that we're addressing feedback and that we can make sure that the migration will be seamless. So definitely stay tuned here but know that that's where we're heading.   MARK KASHMAN: So one thing that I've been just curious about, hearing you talk about the administrative capability to turn off the sync button in the Teams Site, from the Teams Site level, does that same sync button disappearing experience actually happen also in Microsoft Teams? If I'm in the Files tab, which effectively is that shame – same connected SharePoint document library, does the sync button also disappear in Teams?   KATY ERLANDSON: Yeah, so it will also go away in Teams. It's the setting that removes the button for the whole tenant, so – so yeah, Teams will be included in that.   GAIA CARINI: But the Add shortcut to OneDrive option that we've been talking about is already available in Teams, and so if you go to the Files tab and there is – you know, in the general channel—or whichever channel—a folder that you want to make sure you're syncing, you can still use the Add shortcut to OneDrive button from Teams.   MARK KASHMAN: Yeah, that's great, because I think a lot of people kind of ask a broader question, you know, when I'm working in SharePoint versus working in Teams, files being the – what they're talking about. It's that – sometimes that delta of experience.   I know the team is broadly working on, you know, having the capabilities be the same, and I think from a sync perspective it's really important that, if you—from an admin perspective—chose to remove the sync button, by guidance of, you know, using the Add to OneDrive more, as we go into the future, I think a lot of that is kind of comfort food for admins to go, "Okay, I changed it once and that will be adhered to these different entry points that people might be making those choices," which kind of leads me into where I at least wanted to pick your brain.   The Twitter topic was more around what we've been talking about, the sync and Add to OneDrive, how they work together and maybe, you know, a little bit more guidance on what – what to use, when. If we were to step back and just ask the OneDrive team, whether it's a sync question or broader than that, what is the long-term plan? You know, where would you tell people the – the direction that we're going, either in this space or even broader than that?   Gaia, I would start with you.   GAIA CARINI: As Katy mentioned, the long-term plan is to really use the Add shortcut to OneDrive, or Add to OneDrive functionality, to allow users to sync their files across all devices and access them really easily, no matter where they are. As part of that, we have been talking to a lot of customers, and we have heard feedback on some of the gaps in the experiences, or some of the – you know, just feedback from users interacting with Add to One Drive and comparing it to this – the way the sync button syncs files.   And so we were really focused on really understanding all of that feedback and addressing that. We also, in addition to that, need to work on making the migration from the sync button synced content to Add to OneDrive really seamless, both on Windows and Mac, and so that's another thing that we've been looking at and planning.   Eventually, the goal is to fully replace the sync button, and so stay tuned for more information and timelines on that. We don't have timelines on it right now. Again, the – the current focus is really addressing the feedback so we can really make the Add to OneDrive experience the best possible one for users across different scenarios.   MARK KASHMAN: Anything from a – a robust service like OneDrive, especially one that's been in use at scale, managing our customers, especially – you know, for giving IT the tools that they need, and obviously the awareness change management of what's coming or best practices and guidance, I – I certainly think that's a great investment area.   I know, you know, knowing a lot of change, and if it affects our customers negatively because it's a bigger impact or something that they didn't see coming, and this one sounds like it's a perfect way to both blend getting users to think about doing things a little bit differently and that impact not being something that is unmanageable by IT when we make that change.   So Katy, you know, there's probably a lot of feedback that's coming in. What would you say is the number one or top piece of feedback that we're actually working to address?   KATY ERLANDSON: The thing that we hear the most, probably, is this concept of, like confusion around me versus we. With Teams Sites, we kind of said, "Okay, if it's in your OneDrive node, you can think of it as your personal stuff; if it's in your Teams Sites node, you can think of it as shared content, but then users can still share from their OneDrive and then it's – there's a mix of shared content there.   And now, by adding shortcuts into OneDrive, it just adds a little bit more to that confusion, and so our primary focus is to clear that up. It becomes the most problematic around deletes. So if somebody deletes a file that they think is in their OneDrive, and it's just for them, and then that delete is propagated, and then now that's deleted for everybody, and then they don't find out about it until somebody else needs to work on it, and then it's missing.   So that's our top priority. We want to make sure that deletes are super clear. It's clear when it's being deleted for just you or it's being deleted for everyone, and we want users to confirm that before they actually do send that delete out to everybody.   So that's number one. We kind of had this same feedback with Teams Site sync also. It's not really a new problem to add to OneDrive, but it is definitely still there.   MARK KASHMAN: It sounds like, to me, you're going to be increasing—in a positive way—the use and value of the recycle bin and the awareness of "before you throw it away …" and of course, always the awareness of "if it's been thrown away …" you know, the recovery and – and the value there, the value for OneDrive if it's your own set of files, and certainly value if it's a shared set of files.   And it's interesting, the me/we space, I've heard both internally working with MVPs, hearing how they discuss it, and I think the way you're describing it, Katy, a lot of it is the – how does the technology work, and what are the things that, you know, are blocking people from either understanding it or, if they're using it, and they hit some of these—especially like a delete scenario—how to make it so that they do delete something effectively, or if they delete it and they're aware before they maybe accidentally do it.   KATY ERLANDSON: Exactly. We want to make sure that we can prevent it if it's not what they meant to do, and when accidents do happen, we also want to invest in making that recovery be easier.   MARK KASHMAN: Gaia, did you have a thought?   GAIA CARINI: Yeah, I think you both are spot on. On the me versus we topic, I think some of the things we're looking at is really how to surface the fact that the shortcut is from a shared location in File Explorer and Finder. You know, whether that's through the icons we use, or even where the shortcut goes by default.   And so we're exploring different potential paths there, but we know it's definitely a common theme across a lot of customers we've talked to, and so it's really top of mind for our team.   MARK KASHMAN: Do you have – because you work on OneDrive, you most likely use it as much as I do, on a daily basis – you know, if people listening to this, if there was something that's either a recent innovation or something that people, you know, might be just one or two clicks in, and they should know about it, or if it's staring them in the face and – you know, we just want to increase, we know how many times people are using it. Is there any recent or relevant tip or trick of using OneDrive, of just something that you actually use, each and every day, and – and really enjoy?   GAIA CARINI: Yeah, I can start. I have the exciting announcement, as of yesterday. We reached 100% on our file backup, also known as Known Folder Move, for macOS. This feature is something I use every day, across both my Windows PC and my Mac, basically to ensure that all my files on my desktop and my documents folder are in OneDrive, and I can access them across devices, from my phone, if I'm out.   And so it's something we've had on Windows for a long time, and we used – we're really focused on continuing to improve that experience as well. And yeah, as of yesterday, we got to 100% in production on macOS, and it's been something that our team has been working on for a while, and really excited about that.   MARK KASHMAN: Well, congratulations. KFM on Mac is not a small feature to – to build and deliver. Now, it's up to our customers to actually take advantage of it.   GAIA CARINI: Yeah, so we're really looking forward to the feedback on that.   MARK KASHMAN: That's great. Katy, any particular feature or capability that you love about OneDrive, that you use?   KATY ERLANDSON: I think mine also has to be KFM. It's not something that I think about appreciating every day, but just the fact that I don't have to worry about what files are where, on what device. I mean, I'm constantly working on multiple devices every day. I have three going, most days.   So the fact that they're all in sync with where my files are, I know that, you know, I can find a certain spec on my desktop, every time. It's easy, I like it.   MARK KASHMAN: You both keep saying this word, spec. And I'm thinking, maybe we can put all of your specs in your OneDrive for Consumer, and we can share that folder so that the world can sync all of your specs. Do you think that's a good idea?   KATY ERLANDSON: Probably not.   GAIA CARINI: I do have every single file I own—both in my personal life and in my work life—in my OneDrive. Now, of course, whether that's in my personal account or my work account is really important, but yeah, I wouldn't be able to function at all without my OneDrive.   Since you told us to go beyond just sync, I'll tell you one of my other favorite features I use a ton, especially even both at work and outside of work. I love using the PDF signing feature from the mobile app. I feel like that's something that not everyone might know about, but it's so, so useful, so you don't have to print something out and sign it.   For folks listening, if you haven't checked that out, you definitely should.   KATY ERLANDSON: And the PDF scan. I think that's my favorite one –   GAIA CARINI: Yeah.   KATY ERLANDSON: My favorite non-sync feature would be the PDF scan.   GAIA CARINI: Yeah, totally, the PDF scan and then sign, both, whether you're using them together or separate, yeah, for sure.   MARK KASHMAN: That's awesome, I – I think I'm mentioning the same feature. I was just going to say, real quickly, my favorite features is on the OneDrive mobile, and it's when using the expense tool. Sometimes you have a receipt that requires it to be in the system, and I use OneDrive religiously because I typically create a folder for each event that I attend, or each travel, and so I collect my PowerPoints and my videos, and all the – kind of the marketing stuff, but then, inevitably, I have a meal out, and I've got my – my folio from the hotel and all those things.   And I immediately as soon – much sooner than later, I will go into OneDrive, navigate through, sometimes through my Add to OneDrive for these next-gen events folder, and I go to the folder of the event, and then I just save it, and you know, I do a – basically a scan, a document scan of the receipt, and it's very easy to give it a name, put it in the right folder, and then I'm ready to put it in the expense tool when I return.   And it does a great job of cropping the receipt, no matter form the – the receipt is in, and it just puts it – you know, again, kind of in the most compliant space for me, OneDrive, and then is very then easy to upload into that expense tool for each expense report.   So thank you for – for building off of Office Lens, but I think taking it to a level of real usability. It's very easy.   GAIA CARINI: Yeah, I agree, the Clutch feature. We don't thank the mobile team enough for that one.   MARK KASHMAN: Yeah, I mean, honestly, whoever did the Office Lens integration did such a nice job because what you described, around PDF markup, the inking capabilities, you know, that's next level. If you haven't ever done that, it really is – there's a lot that you can accomplish, and it's not a hard-to-use feature. It's really friendly.   Well, thank you for giving us a lot to think about, and to kind of answer this Twitter question in a really nice long form to learn about it and more, especially, you know, kind of the – to get your head on where the team is going, and you know, the best ways to navigate through from an IT perspective, for the benefit of end users. I know that you always – you and your teammates always have the customer in mind for the experience, but also for change management. It's very, very – very important.   So thank you both for hopping off of Twitter and coming to the Intrazone.   GAIA CARINI: Yeah, thanks for having us.   KATY ERLANDSON: Yeah, thanks so much.   (Music.)   MARK KASHMAN: Now you know the difference of using the feature Add to OneDrive, what it does, bringing your shared libraries closer to home within your OneDrive domain, easy access, and how it balances the ways that you might adjust, syncing directly from a Teams Site or directly from a Teams' team. Just Add to OneDrive and then you can get all the sync goodness and more.   Always great to hear directly from the product team, and of course, it's based on that feedback that you've got that I want some clarity on how these things work and what they are. So I really appreciate having Gaia and Katy come in and share all of that insight, plus the insights into how they designed the product, going forward, which I think brings a lot of value—I hope—to you, in your use of OneDrive, going forward.   So let's talk about events. I really just have two events and then a little tickler about what I know about is coming in 2023, without some specific dates. But to round out the year, next up, very soon, at the end of November, is the European SharePoint Conference. This is from November 28th to December 1st, in Copenhagen, Denmark, at the Bella Center. There's going to be four Microsoft keynotes, one with Jeff Teper, another with Scott Hanselman. Karuana Gatimu will have a keynote, and then there will be a developer keynote with Vesa Juvonen.   Of course, there are breakout sessions with Microsoft, Microsoft MVPs and community leads. There's "Ask the Experts," which is a really great one-to-one/one-to-few, just individual chat, "I have a question … here's an answer … or here's some feedback, please listen." Those are always great, and I will be doing three of those, and I know my peers across Microsoft and a lot of our MVPs are taking that time to support the ATEs as well.   And at the European SharePoint Conference there's a really fun "Ask Microsoft Anything," with all of the Microsoft speakers in attendance to answer questions with a SharePoint Connect. This is a nice evening event, sponsored by Microsoft, and we're really pleased and privileged to be in Copenhagen to represent our teams, but also to be a part of the community, engaging in Copenhagen.   Literally the next week, in Las Vegas, is the Microsoft 365 Conference. This is from December 6th through the 8th, again, in Vegas. It's co-located with a couple of events, so you'll see a few other events in the same exact location at the MGM Hotel. There are a number of Microsoft keynotes.   You'll first hear from Scott Guthrie, followed by Jeff Teper. You can imagine the value there, with some of the broader leadership across those broad product portfolios of Azure and Microsoft 365. And similar to a lot of great events, it'll dive into then a lot of breakout sessions, workshops, differing ways to engage. There are of course booths and expo halls, and all of that, to get up to speed with what partners offer, and just a lot of time to network, across both these events.   Whether you're in Denmark, whether you're in Nevada, you have really, really nice back-to-back offerings, and the Microsoft 365 Conference is always a really nice event to plug into and get the depth of knowledge you need, and to get answers and provide feedback so that you can have that nice two-way engagement of the community.   So a little teaser ahead into 2023. These aren't really solid dates, but I know that the 365 Educon team has a number of events in 2023, in Washington, DC, in Seattle, in Chicago. There's the European Collaboration Summit. There's of course different events from the Microsoft 365 Conference team, focused on events on the Power Platform. There will be unique moments for things like Viva and Syntex, and of course, expect some of the larger first-party events that Microsoft put son, like Build, Inspire and Ignite, which has already got the data on it.   If you're interested in Ignite, that's November 15th through the 16th, 2023, which feels like a long time from now, but I can already feel that some of the engines internally are warming up into what does that event look like.   So 2023 is certainly going to be a great year for events. It's something that we, in the broad teams that I represent here, just in referencing, very much look forward to, in plugging in, to round up 2022 with ESPC22, and Microsoft 365 Conference, and then gearing up to have a great 2023, of which of course, Chris and I will always keep you informed on every episode with ones that are upcoming.   (Music.)   We want to thank our guests, Gaia and Katy, for being on the show, and for giving us insights about the value and future of Add to OneDrive. So if you haven't ever added to OneDrive, this episode is the encouragement that you needed. It's a really great feature, and we really appreciate having Gaia and Katy on to explain it, and to also give guidance and a little bit of a look ahead.   We encourage you to check out our show page for the links to all of what was discussed today, and more. You can go to aka.ms/theintrazone, and send us your questions, send us your feedback, whether it's to the SharePoint team, or the OneDrive team, or pretty much anybody here at Microsoft. I'll navigate to what it is that you're looking for, as best as I can.   Just email us at theintrazone@microsoft.com, or find us on Twitter @sharepoint, @onedrive and @mkashman with a K. Remember to rate, review and tell all your friends about the show. This really is the way that we hope to get the word even more broad, to anyone that you know, that you work with, friends, peers, partners, customers that would benefit from the knowledge that we aim to share through this show. We hope that you can encourage other people to follow, and of course, you can get this show where you get your other favorite tech podcasts. Thank you so much for listening. I'm your host, Mark Kashman. This has been The Intrazone, a show about the Microsoft 365, add to cart, Intelligent Intranet. END

To the echoes of ghostly gasps and looming, deadly fog - the spirit of Halloween cast an eerie shadow this past month. No need to fear. October 2022 brought some great new, welcome offerings: Viva Engage GA, Viva Insights: Focus mode in Teams, Stream (on SharePoint) GA, Excel Live in Teams, OneDrive: Folder backup for macOS, conditional access improvement for Lists for Android, Office app becoming Microsoft 365 app, and more. You'll hear more about Viva Engage and Yammer Storylines that both hit general availability. We also pulled audio from Marc Mroz, Principal product manager from the Stream team, to give you a sense of how video in the flow of work evolved as Stream (on SharePoint) hit general availability this past month. It's a treat full-of-new-tricks Halloween edition. Click here for this episode's corresponding blog post. Mark Kashman |@mkashman [co-host] Chris McNulty |@cmcnulty2000 [co-host] Marc Mroz | Twitter | LinkedIn SharePoint Facebook | @SharePoint | SharePoint Community Blog | Feedback Learn more about Viva Engage Learn more about Stream (on SharePoint) "Microsoft Ignite 2022 guide to Viva, Syntex, SharePoint, OneDrive, Lists, Stream, Project and more" - updated with on-demand video content links, new section with 25+ links to relevant announcements blogs, and more. "5 hidden gems from Microsoft Ignite 2022" - new Kashbox article about a few hidden gems from Ignite. Microsoft Docs - The home for Microsoft documentation for end users, developers, and IT professionals.  Microsoft Tech Community Home Stay on top of Office 365 changes Discover and follow other Microsoft podcasts at aka.ms/microsoft/podcasts Upcoming Events: KM World (Nov.7-10.2022) M365 Chicago (Nov.11.2022) Minnesota M365 Fall 2022 Workshop Day (Nov.18.2022) ESPC22 (Nov.28 - Dec. 1, 2022 | in-person Copenhagen, Denmark) Microsoft 365 Conference (Dec.6-8.2022)   Follow The Intrazone at aka.ms/TheIntrazone

On this week's show: Exchange Must Die, according to security experts. SharePoint Syntex is dead, long live Microsoft Syntex. The Metaverse isn't dead yet; AI is coming to learn your job... and Microsoft's new creative tools show a lot of promise.

Time to turn the crank on your Syntex knowledge - now an elevated brand and loads of new innovation. Every workday, Microsoft customers add 1.6 billion documents to Microsoft 365. That content is essential to your organization -- carrying knowledge, decisions, and transactions that are vital to the flow of work. Microsoft Syntex, announced this week at Microsoft Ignite 2022 (Oct.12-14.2022), brings the power of content management and AI together to transform the way we work. Join us as we chat with Ian Story, Principal GPM on the Syntex product team and Alan Pelz-Sharpe, Founder of analyst firm, Deep Analysis. This episode of The Intrazone behind the scenes of this exciting new "Content AI" category and solution. Click here for this episode's corresponding blog post. Social and Info Links: Ian Story (Principal group product manager - Syntex) Twitter | LinkedIn Analyst | Alan Pelz-Sharpe (Founder | Deep Analysis) Twitter | LinkedIn | Website Mark Kashman |@mkashman [co-host] Chris McNulty |@cmcnulty2000 [co-host] Microsoft Syntex | Website | Get started today | Resources | SharePoint Facebook | @SharePoint | SharePoint Community Blog | Feedback Resources: Microsoft Ignite 2022 announcement blog, "Welcome to Microsoft Syntex – Content AI integrated in the flow of work" New Microsoft Mechanics episode: "Introducing Microsoft Syntex | Content AI" with Omar Shahine, CVP - Product management, Microsoft, and Jeremy Chapman, Director, Microsoft product marketing Microsoft Docs - The home for Microsoft documentation for end users, developers, and IT professionals.  Microsoft Tech Community Home Stay on top of Office 365 changes Discover and follow other Microsoft podcasts at aka.ms/microsoft/podcasts Upcoming Events: Microsoft Ignite (Oct.12-14, 2022; virtual + SCC + six regional "spotlights") North American Cloud Summit (Branson, MO) South Coast Summit (Oct.14-15, 2022; Ageas Bowl, Southampton, UK) CollabDays New England (Oct.22 in-person Burlington, MA at the Microsoft MTC) ESPC22 (Nov.28 - Dec. 1, 2022 | in-person Copenhagen, Denmark) Follow The Intrazone at aka.ms/TheIntrazone

Understand and assemble content at scale, discover and reuse your content in intelligent ways, and as an admin, analyze and protect content. Microsoft Syntex content AI services integrate with your digital estate in Microsoft 365 and offer new pay-as-you-go experiences. Product Management CVP for Microsoft 365, Omar Shahine, joins Jeremy Chapman to demonstrate what's available now and what's coming soon. ► QUICK LINKS: 00:00 - Introduction 00:44 - Origins of Syntex 01:47 - IT capabilities 02:29 - Demo: Understand and assemble content 04:44 - Demo: New content creation 07:51 - Content AI 08:26 - Admin roles 11:26 - How to set up Syntex 12:07 - Wrap up ► Link References: Stay informed on Microsoft Syntex at https://aka.ms/syntex ► Unfamiliar with Microsoft Mechanics? As Microsoft's official video series for IT, you can watch and share valuable content and demos of current and upcoming tech from the people who build it at Microsoft. • Subscribe to our YouTube: https://www.youtube.com/c/MicrosoftMechanicsSeries?sub_confirmation=1 • Talk with other IT Pros, join us on the Microsoft Tech Community: https://techcommunity.microsoft.com/t5/microsoft-mechanics-blog/bg-p/MicrosoftMechanicsBlog • Watch or listen from anywhere, subscribe to our podcast: https://microsoftmechanics.libsyn.com/website • To get the newest tech for IT in your inbox, subscribe to our newsletter: https://www.getrevue.co/profile/msftmechanics ► Keep getting this insider knowledge, join us on social: • Follow us on Twitter: https://twitter.com/MSFTMechanics • Share knowledge on LinkedIn: https://www.linkedin.com/company/microsoft-mechanics/ • Enjoy us on Instagram: https://www.instagram.com/microsoftmechanics/ • Loosen up with us on TikTok: https://www.tiktok.com/@msftmechanics 

Newly minted MVP Leon Armston joins us to chat about all things SharePoint Syntex, covering what it is, what you need to use it and some real life scenarios that Leon has used.Leon's Blog SharePoint Syntex | Microsoft 365Automate document generation with SharePoint Syntex and Power Automate (preview) - SharePoint Syntex | Microsoft Docs Licensing for SharePoint Syntex - SharePoint Syntex | Microsoft DocsSharePoint Syntex Adoption – Microsoft AdoptionAI Builder Calculator | Microsoft Power AppsRegex generator – GPT Crush – Demos of OpenAI's GPT-3https://powerapps.microsoft.com/en-gb/ai-builder-calculator/(6) LinkedIn - James EcclesGet started with SharePoint Syntex - Learn | Microsoft DocsSharePoint look book (microsoft.com)PnP Syntex SamplesSyntex RoadmapPhoto by Alex Knight on Unsplash

Mindwalker is an action-packed YA sci-fi novel with one central question at its core: would you ever surrender control of your mind? DO NOT SURRENDER CONTROL. Eighteen-year-old Sil Sarrah is determined to die a legend. But with only twelve months left before the supercomputer grafted to her brain kills her, Sil's time is quickly running out. In the ten years she's been rescuing field agents for the Syntex corporation—by commandeering their minds from afar and leading them to safety—Sil hasn't lost a single life. And she's not about to start now. But when a critical mission goes south, Sil is forced to flee the very company she once called home. Desperate to prove she's no traitor, Sil infiltrates the Analog Army, an activist faction working to bring Syntex down. Her plan: to win back her employer's trust by destroying the group from within. Instead, she and the Army's reckless leader, Ryder, uncover a horrifying truth that threatens to undo all the good she's ever done. With her tech rapidly degrading and her new ally keeping dangerous secrets of his own, Sil must find a way to stop Syntex in order to save her friends, her reputation—and maybe even herself.

https://www.youtube.com/embed/sczJbqEhAUo

We're back! Kevin, Al and Garry return from their break over Christmas and New Year and pick a story each to cover before sharing the latest events.If you would like to appear on the show, we now have a Sessionize link and would love to hear from you over at https://sessionize.com/greyhatbeard/.Syntex content assembly and the content lifecycle - Microsoft Tech CommunityJanuary 2022 – Syntex Licensing Updates and New Year Reflections - Microsoft Tech CommunityGet Started - Microsoft365DSC - Your Cloud ConfigurationThe Surprising Impact of Meeting-Free Days (mit.edu)Notes from a Big Cloud (peterrising.co.uk) Events and other fun26 Jan – M365 S&C UGRegistration - Jan 2022 | MeetupCFS - https://sessionize.com/M365SandCUG/ 17 March – London Power Platform User Group23 Feb – Collab Days Bletchley23 March – Teams NationRegistration - https://www.teamsnation.online/CFS - https://sessionize.com/teamsnation2022/June 29/30 - CommsverseRegistration & CFS - https://www.commsverse.com/ 

The news firehose of Microsoft Ignite has been capped, and now it's time for the recap to re-Ignite your synapses on all that was disclosed. Join Mark and Chris as they walk though tons of announcements from Microsoft Ignite 2021 across SharePoint, OneDrive, Microsoft Viva, Loop, Syntex, Lists, admin, security and more. There's a whole lot coming in the months ahead to improve your content and collaboration, with marked enhancements for employee experiences.  Mark Kashman |@mkashman [co-host] Chris McNulty |@cmcnulty2000 [co-host]  SharePoint | @SharePoint | SharePoint community blog  Microsoft Lists | Resource center | Adoption | Posts within Microsoft 365 community blog Microsoft Loop  Resources: "Microsoft Viva is now generally available to help transform your hybrid work experience" by Seth Patton Microsoft Ignite 'Book of News' 2021 Microsoft Ignite 'ODSPV Guide' (list of related blogs, sessions, and more:  Microsoft Lists resource center Microsoft Docs - The home for Microsoft documentation for end users, developers, and IT professionals.  Microsoft Tech Community Home Stay on top of Office 365 changes Listen and subscribe to other Microsoft podcasts at aka.ms/microsoft/podcasts Upcoming Events: Microsoft Tech Community Live: Microsoft Viva Edition - a video AMA (Nov.16.2021 8am-12pm PST) Teams Day Online (Nov.17.2021) European Collaboration Summit (Nov.29 - Oct. 1.2021) Microsoft 365 Collaboration Conference - Vegas (Dec.7-9.2021) 365 EduCon - DC (formerly SP Fest) (Dec.12-16.2021) 365 EduCon - Dallas (formerly SP Fest) (Jan.31-Feb.4.2021) Follow and subscribe to The Intrazone at aka.ms/TheIntrazone

Greg Taylor brings his wealth of experience in Exchange to the show, discussing the upcoming deprecations in the Exchange online service. Links from the show: Upcoming API Deprecations in Exchange Web Services for Exchange Online - Microsoft Tech Community Basic Authentication and Exchange Online – September 2021 Update https://aka.ms/graphtapform Microsoft News Announcing SharePoint Framework 1.13 – Extending Microsoft Viva Connections Microsoft Ignite 2021 guide to SharePoint, OneDrive, Viva, Lists, Syntex, Stream, Visio and more Community Links Getting working hours/time zones for other users using Microsoft Graph API Simple Teams Tab Single-Sign-On with Microsoft Graph (@wictor) Sending e-mails with Microsoft Graph using .NET (@zimmergren) Sending Emails Using Microsoft Graph PowerShell Microsoft Graph PowerShell – Backticks vs. Splatting vs. Class Objects

Tom Resing joins Paul at SPFest in Chicago to talk about his work as a Content Designer on SharePoint Syntex. Microsoft News Microsoft Graph .NET SDK v4 now generally available with streamlined authentication and more Breaking changes to the Microsoft Graph connectors API (beta) What's Coming to OneNote Community Links Fetching Teams User Info from Microsoft Graph with TeamsFx SDK Bring external data into Microsoft 365 using Graph Connectors

This week we are joined by Paul Dredge, Senior Technical Consultant at Hable, as we discuss the latest news on Teams for Personal, Webinars, Syntex samples and more.Microsoft Teams now brings family and friends together to call, chat, and make plans Introducing Webinars in Microsoft Teams: Easy, professional webinars to engage customersFive new features enhancing Adaptive Cards in Microsoft TeamsMigration Manager: Dropbox migrationsSyntex model samplesThe benefits of deploying built-in labeling within Microsoft 365 appsThree Considerations for Azure Information Protection Deployments'Huge shortage' in digital skills says Apprentice winnerSony's PlayStation to integrate Discord chat for gamersBox as the source for Tech Community documents? EventsLearn Git on TikTok with Christos Matskas25-27 May - Microsoft BuildNext M365 Comp and Sec May 19 May 2021 | MeetupSouth Coast Summit – A Microsoft Cloud Technology ConferenceSouth Coast Summit 2021 - Security & Compliance Workshop Tickets, Fri 15 OctSouth Coast Summit 2021 - Microsoft Viva and Syntex Workshop Tickets, Fri 15 OctTech Community Awards - Commsverse | A Microsoft Teams ConferenceAgenda 2021 - SharePoint Saturday Cologne (spscgn.azurewebsites.net)How to measure Wellbeing and Productivity using Viva Insights - AlAn introduction to knowledge management with Viva Topics - KevinMicrosoft 365 Chicago Virtual Event (m365chicago.com)How to measure Wellbeing and Productivity using Viva Insights - Al

Hur hittar vi rätt information i våra dokument? Vi får hjälp av SharePoint Syntex. Visste du att Power Automate kan hjälpa dig att automatisera i dina desktopapplikationer? Lösningen heter Robotic Process Automation och är gratis om du kör Windows 10.

We're Back! Well, I'm back - Rob, that is. Kat has moved on to a new adventure and I couldn't be happier for her. This month, we learn that New Signature is now Cognizant Microsoft Business Group, The SharePoint App Bar is coming, Microsoft Viva is the Next Big Thing, and friend of the podcast Oliver Bartholdson returns to discuss how SharePoint Syntex is AI that works for you. I'll be back every month like before with a new episode, and keep listening, because the search is on for a successor to Kat.

Drag and drop emails and attachments from Outlook into SharePoint, without leaving Outlook. We talk with Microsoft partner harmon.ie, along with their customer, Bosch. We'll highlight their solution for how emails and attachments are now saved to SharePoint - readily available for future audits and e-discovery. The combined SharePoint plus harmon.ie solution helps Bosch manage millions of daily emails, including active business records that need to be accessed, shared, and worked on by numerous colleagues. Click here for this episode's corresponding blog post. SharePoint | @SharePoint | SharePoint Community Blog | UserVoice David Lavenda | LinkedIn | Twitter | harmon.ie (Twitter) [guest] Daniel Stuch | LinkedIn | Bosch (Twitter) [guest] Mark Kashman | Twitter [co-host] Chris McNulty | Twitter [co-host] Events: Microsoft Ignite (Mar.2-4.2021) Collab365 GlobalCon5 (Mar.16-17.2021) | Twitter Reimagine Project Management with Microsoft (Mar.18.2021) SharePoint’s 20th Birthday Party (Mar.27.2021) The AIIM Conference (Apr.27-29.2021) SharePoint Fest Virtual Workshops (ongoing) CollabDays events (ongoing) SharePoint Saturdays events (ongoing) Resources: Microsoft 365 Content Services Partner Program Microsoft Partner Network Microsoft Viva https://aka.ms/Viva SharePoint Syntex https://aka.ms/SharePointSyntex Content Services https://aka.ms/sharepoint-contentservices Microsoft Docs - The home for Microsoft documentation for end users, developers, and IT professionals.  Stay on top of Office 365 changes Subscribe to The Intrazone at aka.ms/TheIntrazone Listen and subscribe to other Microsoft podcasts at aka.ms/microsoft/podcasts

https://www.youtube.com/embed/ZyypqvCelq8

January 2021 brought a lot of new tech: Yammer notifications in Teams, inclusive Yammer reactions, OneDrive settings in SharePoint admin center, 250GB file uploads, Microsoft Lists app for iOS, Lists rules, Lists forms customization, and more. We, too, get a bonus chat with Dan Holme, principal product manager lead on the Yammer and Groups team, about his recent career move, new Yammer tech and his new life in Arizona. Click here for this episode's corresponding blog post. Resource and Info Links: SharePoint Facebook | Twitter | SharePoint Community Blog | UserVoice Mark Kashman | Twitter [host] Dan Holme | LinkedIn | Twitter [guest] Microsoft 365 public roadmap Microsoft Tech Community Home Microsoft Docs - The home for Microsoft documentation for end users, developers, and IT professionals.  Microsoft Tech Community Home Stay on top of Office 365 changes Subscribe to The Intrazone at aka.ms/TheIntrazone Listen and subscribe to other Microsoft podcasts at aka.ms/microsoft/podcasts

December 2020 brought many new offerings: SharePoint site header updates, send pages to Yammer, “SharePoint Success” site template, add Microsoft Teams to SharePoint team sites update (aka, Teamify), Microsoft Lists adoption center, Microsoft Graph Toolkit v2.0, and more. We share an exclusive chat with Tejas Mehta, principal program manager on the SharePoint team who owns content services integration work with Microsoft Teams. And Mark recaps The Intrazone's top episodes of 2020. Click here for this episode's corresponding blog post. Resource and Info Links: SharePoint Facebook | Twitter | SharePoint Community Blog | UserVoice Mark Kashman | Twitter [host] "Over 200 million users rely on SharePoint as Microsoft is again recognized as a Leader in the 2020 Gartner Content Services Platforms Magic Quadrant Report" Microsoft 365 public roadmap Microsoft Tech Community Home Microsoft Docs - The home for Microsoft documentation for end users, developers, and IT professionals.  Microsoft Tech Community Home Stay on top of Office 365 changes Subscribe to The Intrazone at aka.ms/TheIntrazone: Apple Podcasts Amazon Music Google Play Spotify Stitcher TuneIn Overcast RadioPublic iHeart RSS Listen and subscribe to other Microsoft podcasts at aka.ms/microsoft/podcasts

In Episode 208, Ben and Scott continue their conversation on SharePoint Syntex and discuss "form processing", how it contrasts to "document understanding", and leverages Power Automate and AI Builder to perform extraction from structured and semi-structured documents. Sponsors Sperry Software – Powerful Outlook Add-ins developed to make your email life easy even if you're too busy to manage your inbox ShareGate - ShareGate's industry-leading products help IT professionals worldwide migrate their business to the Office 365 or SharePoint, automate their Office 365 governance, and understand their Azure usage & costs Office365AdminPortal.com - Providing admins the knowledge and tools to run Office 365 successfully Intelligink - We focus on the Microsoft Cloud so you can focus on your business Show Notes Here are all the new Marvel, Star Wars, and other projects Disney announced at its investor day Episode 207 – What Is SharePoint Syntex? Introduction to Microsoft SharePoint Syntex Form processing overview Difference between document understanding and form processing models AI Builder credits AI Builder Calculator Improve business performance with AI Builder About the sponsors Every business will eventually have to move to the cloud and adapt to it. That's a fact. ShareGate helps with that. Our industry-leading products help IT professionals worldwide migrate their business to the Office 365 or SharePoint, automate their Office 365 governance, and understand their Azure usage & costs. Visit https://sharegate.com/ to learn more. Sperry Software, Inc focuses primarily on Microsoft Outlook and more recently Microsoft Office 365, where a plethora of tools and plugins that work with email have been developed. These tools can be extended for almost any situation where email is involved, including automating workflows (e.g., automatically save emails as PDF or automatically archive emails that are over 30 days old), modifying potentially bad user behaviors (e.g., alert the user to suspected phishing emails or prompt the user if they are going to inadvertently reply to all), and increased email security (e.g., prompt the user with a customizable warning if they are about to send an email outside the organization). Get started today by visiting www.SperrySoftware.com/CloudIT Intelligink utilizes their skill and passion for the Microsoft cloud to empower their customers with the freedom to focus on their core business. They partner with them to implement and administer their cloud technology deployments and solutions. Visit Intelligink.com for more info.

In Episode 207, Ben and Scott start digging into SharePoint Syntex by exploring “document understanding” capabilities of the service. Sponsors Sperry Software – Powerful Outlook Add-ins developed to make your email life easy even if you're too busy to manage your inbox ShareGate - ShareGate's industry-leading products help IT professionals worldwide migrate their business to the Office 365 or SharePoint, automate their Office 365 governance, and understand their Azure usage & costs Office365AdminPortal.com - Providing admins the knowledge and tools to run Office 365 successfully Intelligink - We focus on the Microsoft Cloud so you can focus on your business Show Notes Introduction to Microsoft SharePoint Syntex Set up SharePoint Syntex What is SharePoint Syntex and how much does it cost? Document understanding overview Form processing overview Create a content center in Microsoft SharePoint Syntex Create a classifier in Microsoft SharePoint Syntex Introduction to explanation types About the sponsors Every business will eventually have to move to the cloud and adapt to it. That's a fact. ShareGate helps with that. Our industry-leading products help IT professionals worldwide migrate their business to the Office 365 or SharePoint, automate their Office 365 governance, and understand their Azure usage & costs. Visit https://sharegate.com/ to learn more. Sperry Software, Inc focuses primarily on Microsoft Outlook and more recently Microsoft Office 365, where a plethora of tools and plugins that work with email have been developed. These tools can be extended for almost any situation where email is involved, including automating workflows (e.g., automatically save emails as PDF or automatically archive emails that are over 30 days old), modifying potentially bad user behaviors (e.g., alert the user to suspected phishing emails or prompt the user if they are going to inadvertently reply to all), and increased email security (e.g., prompt the user with a customizable warning if they are about to send an email outside the organization). Get started today by visiting www.SperrySoftware.com/CloudIT Intelligink utilizes their skill and passion for the Microsoft cloud to empower their customers with the freedom to focus on their core business. They partner with them to implement and administer their cloud technology deployments and solutions. Visit Intelligink.com for more info.

In the spirit of Halloween, the Ghost of Roadmap Past shall be your guide – helping you to avoid becoming a Roadmap Scrooge. October 2020 brought some great new offerings: SharePoint Syntex, Organization Chart web part, new IT controls for Microsoft Lists, Microsoft Lists – commenting, OneDrive widget for iPhone, Task in Teams GA, and more. Warning: this episode is “ghostly-spirited" at times – all to help answer, "What rolled out to SharePoint and related technologies in Microsoft 365 during October 2020?" Click here for this episode's corresponding blog post. Click here for transcript of this episode. Resource and Info Links: SharePoint @SharePoint | SharePoint Community Blog | UserVoice Mark Kashman | Twitter [host] Harsh Agarwal | LinkedIn [guest] Microsoft 365 public roadmap Microsoft Tech Community Home Microsoft Docs - The home for Microsoft documentation for end users, developers, and IT professionals.  Microsoft Tech Community Home Stay on top of Office 365 changes Subscribe to The Intrazone at aka.ms/TheIntrazone Listen and subscribe to other Microsoft podcasts at aka.ms/microsoft/podcasts

https://www.youtube.com/embed/ok4CMhcsq9M

Steve Sordello is the CFO of LinkedIn and serves on Santa Clara’s Board of Trustees. Prior to LinkedIn, Steve was CFO of TiVo, CFO of Ask Jeeves, and held senior management roles at Adobe Systems and Syntex (now part of Roche). Steve holds a MBA from Santa Clara and a degree in business administration. Raised in the Bay Area, Steve grew up working amid his parents’ apricot, prune and walnut orchards.In this conversation, we discuss lessons Steve learned from his CFO roles, differences between small and large companies, how LinkedIn is mapping the global economy, how Steve balances short-term shareholder obligations with long-term social impact, and what career advice Steve would give college students. See acast.com/privacy for privacy and opt-out information.

Dr. Mohammed is the Founder and President of ManaGene considered one of the most innovative leaders in the emerging personalized medicine and lifestyle genomics space.   In August 2018, ManaGene merged with Youtrients (www.youtrients.me) to form a new company known as The DNA Company. The DNA Company represents the evolution of functional genomics and is focused solely on the optimization of human health and performance.   Dr. Mohammed is widely regarded as a pioneer in medical genomics and has been the recipient of multiple academic and industry awards. He is the holder of several patents in the general fields of molecular diagnostics and genomics research and is one of the most sought-after national and international conference speakers in the genre of personalized medical genomics. In this interview, Lisa and Dr. Mansoor dive deep into the power that lies in understanding your unique genes to change the outcome of your health.   Some take the fatalistic view that if you have a bad gene or combination of genes you are powerless against them so it's best not to know but nothing could be further from the truth. Understanding your genes through DNA testing is like getting the user manual to your body and learning how best to care and treat it. The granularity with which you can start to understand processes and how these affect you and how you impact these is astounding.   This s actionable knowledge that will help you make informed decisions regarding your health in such areas as your hormones, your cardiovascular risk factors, your methylation, your detoxification processes and even your mood and behavior, why for example some have a tendency to more problems around depression or PTSD than others.    Never before in the history of the human species have we had such deep insides into the way our intricate and complex bodies work.    This episode is set to blow your mind and the work of Dr. Mohammed and his team is set to change the future of the world's health. We have the opportunity for the first time to take control of our own destinies rather than falling victim to our genes through a lack of knowledge.   Once you start to see and understand the power of functional genomics you won't be able to go back to the way you understood yourself and your body before. Your level of self-acceptance and the ability to help yourself heal and be healthy and whole will be taken to a whole new level.   If you would like to get your hormones or your whole genomic profile tested you can find out more at www.thednacompany.com    We would like to thank our sponsors for this show:   www.vielight.com   Makers of Photobiomodulation devices that stimulate the brains mitocondria, the power houses of your brains energy, through infrared light to optimise your brain function.  To get 10% off your order use the code: TAMATI at www.vielight.com   For Lisa's New Book Relentless visit the website below to order https://shop.lisatamati.com/products/relentless   When extreme endurance athlete, Lisa Tamati, was confronted with the hardest challenge of her life, she fought with everything she had. Her beloved mother, Isobel, had suffered a huge aneurysm and stroke and was left with massive brain damage; she was like a baby in a woman's body. The prognosis was dire. There was very little hope that she would ever have any quality of life again. But Lisa is a fighter and stubborn. She absolutely refused to accept the words of the medical fraternity and instead decided that she was going to get her mother back or die trying.   For more information on Lisa Tamati's programs, books and documentaries please visit www.lisatamati.com    For Lisa's online run training coaching go to https://www.lisatamati.com/page/runningpage/ Join hundreds of athletes from all over the world and all levels smashing their running goals while staying healthy in mind and body.   Lisa's Epigenetics Testing Program https://www.lisatamati.com/page/epigenetics/ Get The User Manual For Your Specific Genes Which foods should you eat, and which ones should you avoid? When, and how often should you be eating? What type of exercise does your body respond best to, and when is it best to exercise? Discover the social interactions that will energize you and uncover your natural gifts and talents. These are just some of the questions you'll uncover the answers to in the Lisa Tamati Epigenetics Testing Program along with many others. There's a good reason why epigenetics is being hailed as the "future of personalized health", as it unlocks the user manual you'll wish you'd been born with!  No more guesswork. The program, developed by an international team of independent doctors, researchers, and technology programmers for over 15 years, uses a powerful epigenetics analysis platform informed by 100% evidenced-based medical research. The platform uses over 500 algorithms and 10,000 data points per user, to analyze body measurement and lifestyle stress data, that can all be captured from the comfort of your own home   For Lisa's Mental Toughness online course visit:  https://www.lisatamati.com/page/mindsetuniversity/ Developmental strength, emotional resilience, leadership skills and a never quit mentality - Helping you to reach your full potential and break free of those limiting beliefs.    For Lisa's free weekly Podcast "Pushing the Limits" subscribe on iTunes or your favorite podcast app or visit the website  https://www.lisatamati.com/page/podcast/     Transcript of the Podcast   Speaker 1: (00:01) Welcome to pushing the limits, the show that helps you reach your full potential with your host, Lisa Tamati, brought to you by Lisatamati.com Speaker 2: (00:13) Hey team. We're this week I have an absolutely superstar, the world's number one leading functional genomic specialists, Dr. Mohammed from Toronto and Canada. Dr Mansoor, Mohammed has two guests now. He is a scientist and entrepreneur in the field of genomics and is regarded as one of the most innovative leaders in the emerging personalized medicine and lifestyle genomic space. Dr Mohammed is a PhD and president and scientific officer at the DNA company and is really considered to be a pioneer medical genomics. He's a classically trained molecular immunologist who has received academic and industry awards, published numerous papers and holds patients in the general fields of molecular diagnostics in genomics. Now functional genomics is about understanding the DNA and how it behaves in every definition and this Dr. Mentor was very different than many of the other DNA companies that I've looked at recently and that he doesn't just look at the single litters, if you like, of the DNA, but it looks in combinations of genes. Speaker 2: (01:22) And how they're playing out. And this makes him very, very different. This, he sees DNA like a language rather than a vocabulary and language that has grammar, sentence structure, Syntex and nuances. And you've got to be able to read genetic structure at the holistic level. Now I'm super excited about document's all his work and I'm studying functional genomics at the moment and it is the next level in personalized health. I'm really, really excited to bring this interview to you. It's taken me months to get documents or on this podcast and I'm hoping later on the year to get Dr. Mansoor Down to New Zealand for a lecture tour to speak to functional medicine practitioners down here as well as the public. So if you'd like to know more about that, please reach out to me and let me know. I'm just like to remind you before I hand over to Dr. Mansoor that my book launch is happening just next week over the time of this recording is the 6th of March and on the 11th of March. Speaker 2: (02:26) So by the time this recording actually comes out, my book will be live. It's called relentless and it tells the story of bringing my mum back after a major aneurism myth. You're fighting for a life and lift her in and basically not much over a vegetative state. Massive brain damage at the age of 64 and what I did to beat all the odds and bringing my mum back to health, all of the CRPS I used, the protocols, the attitude, the mindset, the obstacles that we had to overcome, the problems that I've discovered in our medical system in on it goes. So this book is really, I'm, I'm so pleased to be able to bring it out. It's taken me two years to get this together and to bring it to the public, but I really want to pay it forward and I want to help thousands and thousands of other people facing difficult challenges to take them are hit on with the right mindset to overcome great obstacles. Speaker 2: (03:18) So if you'd like to check that out, we can head over to my website. I have Lisatamati.com Hit the shop button and you'll see all of my books there and my jewelry collections. But make sure you check out the neatness. It's really going to be worth a read for anyone who has major medical problems at the moment. Or of course anyone who has a stroke aneurysm Alzheimer's dementia, and wants to know about brain rehabilitation or optimizing your brain function and who isn't interested in that as well as the whole mental attitude and mindset that it takes to do all this. So without further ado, over to Dr. Mansoor Mohammed. Well, hi everybody. Lisa Tamati here at pushing the limits. It's fantastic to have you back again. Now I am just grinning from ear to ear. I can't stop smiling because I've been waiting for this interview for weeks. I have a very, very special guest, Dr. Mansoor Mohammed, all the way from Toronto in Canada. Dr. Mansoor How are you going? Speaker 3: (04:17) I am great, Lisa. And likewise, it's been something that I've been looking forward to, to the audience. Please forgive me. I'm a little bit sleepy from Jeff blog from last night, but Lisa has been pumping me up and so we're going to have some fun of this Speaker 2: (04:31) Now. I know what it's like when you're a little bit jetlagged and you have a main very much in demand. So I'm just so excited to have a little bit of time with you now. Dr Mansoor, I do the whole introduction on a separate recording, but dr Mansoor, can you give us a little bit of background about your what you did your PhD in your, your, a little bit of a brief history of your back. Speaker 3: (04:55) Sure. genes. Genetics has always have always been my love. The study of how this operating manual, just just thinking, just, just dialing it back and thinking that the human being, we've got this operating manual that by every definition of the word it behaves like an operating manual. And to think that it's there and to think that one date might be accessible and that we could read this and we could read it intelligently and just simply understand myself much less, much less. Anyone else has always been my love. And so I started, my PhD is in applied molecular genetics and immunology. So I was looking at the genetics of the immune system. I was very, very fortunate to have an awesome mentor. She was then the chair of molecular biology at UCLA invited me to UCLA. So I had an awesome couple of postdocs there where I got deeper and deeper involved in eugenics. Speaker 3: (05:47) But a real pivotal point happened when I was done, invited to come to Baylor college of medicine and Houston, Texas. And it was that heavy time just about the human genome project, its, you know, sort of pinnacle. And I was asked because of the work that I had been doing with UCLA to come over to Baylor and start a company, the goal of this company was to begin looking at multiplex genomics. In other words, to really do the, you know, the barrage searches into the human genome. Not one gene at a time, but looking at the entire genome in pathway type manners. Now initially we applied this knowledge to cancers. We apply this knowledge to developmental disorders syndromes, Prader, Willi syndrome, autistic spectrum disorders and so on and so forth. And about 15 years ago, after many years of doing what I call disease genomics, looking at the operating manual, looking at when the operating money was broken out of what happens from a disease perspective. Speaker 3: (06:45) Then I sort of thought, okay, well that was fun. That was good. That was, but why should I not look at the operating manual? But nothing is purportedly broken, but just the operating manual. So then still we can tell presumptively healthy individuals how to stay healthy or how to get over the type of chronic illnesses. So this is what I've been doing for the last 15 years, studying, researching and applying the knowledge of the human genomic operating manual. So we've been, we can just simply understand it. How does the body work, which clearly there's an individuality to that, obviously. I mean, we are human beings. We all, our cells, our organs, our bodies, all have to accomplish the same jobs that we do. These jobs with nuance differences, some of us less optimal, more optimal, more efficient, less efficient. And when we can zone into that, when we can read this operating manual from that perspective, really Lisa miracles happened with the sort of insights that you get, the nuances that you can tease out. It really has transformed the clinicians. We train the patients, we work with the transforms, it empowers the individual to understand how their body works and what they might do to obtain that optimal health. Speaker 2: (07:59) This is, and this is a super exciting and I can feel your passion coming through despite the jet lag for this area and it's now mind you, passion is of the last maybe two months or six weeks or however long it is now that I've been diving into this world and just going, Oh my gosh. Oh my gosh, this is just, this is just the next level and the information that I've been searching for to try to understand because everything seems so generic. And this a personalized house and yeah, doctor man saw you the president and founder of the DNA company, which is offering direct to public and in conjunction with conditions. A couple of reports. So our full genomic report in a hormone report and I want to tease apart a little bit today, why should people even consider having a look at these, the sort of testing what benefits they can get out of it. Speaker 2: (08:58) And I'd like to also tease a little bit about looking at other, like I've, I've looked at a lot of gene companies and that do gene DNA testing. And you had an analogy on a Bulletproof radio that I heard you on the same show who's amazing Dave and his work that was about the most people are looking at it DNA as a vocabulary and not a language. And that just seems them light bulb up in my head where I realized, okay, so it's not the siloed genes looking at them individually, but looking at cascades and pathways and combinations of genes as we are then interpretation has been missing today. Speaker 3: (09:43) Oh, 100%. So I always say, you know, Lisa, anyone that is in the data business, regardless of whatever data you're collecting, data is really quite dumb. Data in and of itself doesn't mean anything unless you know what to ask of the data unless you know how to triage, how to approach the data. So when we use the analogy as DNA, the operating manual, the genome, it really meets all the classifications and descriptions of a language. Thus far we've been looking at DNA and genetics from a language perspective purely as a vocabulary exercise. The more words we know, the better we presume to think we know the language. And as much as that is important as per the analogy that I drew with on Dave, show a person simply knowing more vocabulary by no means mean they understand the language. And so when it comes to DNA, when it comes to genetics, when it comes to how this awesome operating manual, the architecture of it, it's not just about vocabulary, it's not just about the individual genes. Speaker 3: (10:51) So here are the two layers implicit in your question that we do a bit differently and why we need to do that differently and why it's important that it's done this way. The first is this. When you're looking at the DNA, if the person are either genetic makeup, the vast, vast majority of companies right now, they're looking at things called snips, single nucleotide polymorphisms. In other words, they're looking at places which is absolutely important. They're looking at spelling variations in this operating manual. And of course these spelling variations, these single nucleotide polymorphisms will impart to you mean Jane, Paul, Peter, the same cellular job that we all want to do. These spelling differences can impact the efficiency with which we do that job and that is important to know, but while we're at that point of spelling, you see per any language, if I wrote a paragraph, I might have spelling errors in that paragraph, but there are examples where I may have inadvertently deleted a sentence or deleted a couple of sentences in that paragraph. Speaker 3: (12:00) Now, if the analogy here is that the gene is the paragraph, so your operating manual are these 23 volumes. Think of it. Think of a 23 volume and psychopathic set these awesome, huge volumes. Now we're going to inherit two of these 23 volumes. One from mom, one from dad, and these volumes are properly arranged and when we open up any page, let's say we go to volume three from mum volume three from dad, we open up page four on each of those volumes and we look at paragraph five page four, volume three we, I see the same paragraph. We're going to see the same information from dad's gene paragraphs of genes and mom's gene. We're going to see the same information, but when we look really carefully, when we look at those paragraphs, really collect carefully, we might find that there's some spelling differences. Those are the snips. Speaker 3: (12:57) We may also find that on either dad or mom's paragraph, a sentence was missing and I just taught this over the weekend. So I was in the auditorium and I said, okay, here's an instruction that was waiting for me coming to this auditorium to give this lecture, Dr Mansoor, go to auditorium B and to the left door approach to podium from the right side, press the enter button, begin your lecture. That's an instruction. That's a paragraph. That's an instruction and that's the equivalent of a gene. Now in that paragraph they make has been a few spelling errors or changes that may have confused me a little as to what the instructions are. But when I look at it carefully, I could sort of still figure it out. Okay. But if in that paragraph, the sentence that says go to auditorium B was missing at, of course there are multiple auditoriums, all of the other parts of the instructions are there. Speaker 3: (14:03) But I can really be confused as to what is the ultimate thing that I'm supposed to do. It's called an indel. So in our genes, not only do our genes have slips, many important genes actually have places within them that I'm missing. So until we test for those type of changes, we're by no means getting the full picture of what is happening. The third thing is this, not only do we have slips, not only do we have in Dells, there are occasions where the entire gene is missing is show I'm supposed to show up. I got to the hotel where the conferences are and the instruction just telling me what it's just not even there. So here I'm in the lobby going, I don't know what I'm supposed to do. This example is a genetic phenomenon keeping the analogy, this is called this C and V copy number variation. Speaker 3: (15:03) We see because we were supposed to have two copies of that. Paragraph five page four, volume three. Sometimes believe it or not, when we go to page four we've opened up mum's volume three dad's volume three. There they are. We're going to read both of the instructions cause that's what yourself has to do at any given moment. When there's a job to be done, your cell goes and pulls the volume that has that instruction, takes down a mum's copy, takes down, dad's copy, opens up and reads the instruction. Now in the case of a CMV copying of the variation, we can open up mum's volume three page four there is paragraph one, paragraph two, paragraph three paragraph four paragraph six. Oops, wait a minute. Where's part of our five? It's gone. There's part of four. There's part of six. I look over a dad. He's got all of the paragraphs or vice versa. Speaker 3: (16:02) Sometimes Lisa, both paragraph fives are gone. Okay. So the point of the first answer to your question, why we do things a bit differently is we're not just in the business of collecting data for data's sake. We're collecting data. Are you were doing gene testing to understand a process. When we designed genetic tests, we don't begin with genes. We begin in a whiteboard saying, what is the thing in the human body that we want to study? What is the thing that we want to study? Genetics, just good old fashioned medical textbook, human physiology. Do we want to study the way the newer chemicals are produced and bonding and response? Do we want to study how the human body makes sex hormones? Something we should talk about when it comes to human performance. So how does the male and female body makes progesterones androgens Astros? And then we mapped that out. Speaker 3: (16:56) Forget genetics, which is not about how does the human body do that? No, of course, if the human body's having to do something, then it means there are genetic instructions for that film. So only when we map out the cellular, the cellular biology, the cascade, only when we met that out, then we come in and we pencil it. This gene is responsible for here. This gene is responsible for there such that at the end of the exercise, we've got a genetic test that already tells a story. The result from that genetic test is telling you the entire cascade. Step one, step two. We look at each of those genes that are telling us the story and we ask are these snips that are important? Are there entails that are important? Are the CNVs that are important because all three make a wow. And so the first part to the answer to your question is if you've been looking at genetic tests that are only reporting snips, you are dramatically limiting the variations that you and I and every other person have within our genome. So you're missing the nuances that are in your language to clarify the job to be done. Does that make sense? Speaker 2: (18:16) Absolutely. So that actually puts them together in my head because I've been starting this, I don't know, like for example, the GSTT one gene and the detox and antioxidant pathway, one of those types of genes that can be completely done. Speaker 3: (18:31) Completely. Totally said, absolutely. And of course it belongs to super family. So there are multiple G S T genes, but two minutes on that. If you're going to design the human body and you're going to say, listen, one day we're going to make this thing called human being and we're going to put him or her in this wonderful world, but mind you, he or she is going to have to deal with some toxic insults, both from without and from within. Where would you, and you know that, where would you put your detox defenses? Well, they're about four places. If you're an intelligent designer, you would put your detox, different defenses at least in four places. You would say, how and where do things get into the human body, dermal skin, the nose, nasal Bronxville lung, the GI track. Okay. So those are how things get it. Speaker 3: (19:23) And unsurprisingly you would want to make sure your detox genes and the things that you'd want to make sure there's super active in those places. And then you, you'd also say, well look, at the end of the day, things are always going to get past borders inside of the body, their waste products. So then I'm also going to put a detox organ. The liver, when we go to the human body, this is where we find these detox genes expressing themselves. And each of the GST is have sub specialties. Some of them are more important in the nasal bronchial track, some of them more important in the GI track and so on and so forth. So when you know the story that you want to read about the body, you know how to read the manual and interpret, is the GST T one gene deleted or not? This is a massive implication to the human body. Speaker 3: (20:16) Can you imagine the GSTT one gene is one of, if not the most important bio transforming antioxidizing enzymes in the body per its name and its gene and its enzyme. And if a person doesn't have it, literally it's not in mere manual. The GSTT one gene is on volume 22 and if that paragraph you have not inherited it from either mum or dad, you are missing an enzyme in your body. That is one of the most important detox. Now doesn't mean that you're not compatible with life, but it most certainly means you could not be the person who says, well you know what do you have a metals mean after all they're not that bad. Oh you know what, my uncle smoked until he was 80 years old. I'm going to smoke as well. Well you can't compare yourself to that person cause you don't have one of the most awesome detox genes. Speaker 2: (21:13) You don't have a good defense mechanism. And so like the detox is actually the first port of call before the immune system even does this job. So I'm, I'm excited to get my tests back cause I haven't gotten gotten through the reports yet. I'm, I'm suspecting that I have a problem in my GC jeans because I'm a very young age. For example, I've been the next medic as a, as a severe asthmatic, as a child, and I'm very hypersensitive to smells and anything. So I'm like a Canary one C one, which is theta. Yes, Speaker 3: (21:54) Very important in the liver. Key one PI GSTP one is the one that's really important in your nasal bronchiolar lung cavity. Individuals with a suboptimal P one are at extreme risk of early ectopic asthmas. They're the ones that if they go into the shopping mall, you know, the perfume resection, they've got to avoid the perfume resection. Right? Those are the GSTP ones. Speaker 2: (22:21) Wow. I'm obey. Fascinating to see if that's what comes back. And so if you want it deleted into them, we'll get onto hormones next because I really want to dive into there, but just to, to to look at the GST genes. If you don't have, you either have only one inherited GST, one gene, your mother or your father and you're missing the other ones or you're missing both altogether, are you more likely to have you're more likely to have toxins coming in that you can't deal with as well. And then your immune system is this way or auto-immune or part of the Speaker 3: (22:57) Brilliant, brilliant question. Just before we answer that, I had mentioned there were two layers to differentiate yourself, so just so that we close the chapter on what we do differently. So I'm going to come back and, and so now we will take it forward. We just mentioned that there you have to be mindful of the three different layers of variations, snips in Dalles with pieces of the genome missing and CNVs where the whole gene may be missing. The other quick differentiator, bringing back the analogy of a language, bringing back the story of the human body, it's this, and I told the audience this, there was an audience of clinicians in Phoenix this weekend. I said, have you ever read a really good, you know, suspense novel and not suspense novel, the novel that the author's painting the character and you're thinking he's the bad guy, you know, and he's falling around the heroin and he knows he looks a bit shady. Speaker 3: (23:51) And then until or unless you've read the entire book, you only find out that he was a protector or he was something. He was a guardian and words. He wasn't about that guy. Now what the heck does this have to do with genes? The second player, when we mentioned that we do things differently, we said that DNA is really a language by all of its definitions, with its nuances is this, there are many genes, Lisa, where if you were to look at that gene as a standalone and if you was to look at the genotype of that gene, in other words, what version do you have? You think you have either the best version or the worst version depending, and you may think you have the best version for example, but it is not until you look at a completely independent gene that has nothing to do with this gene, that the version of that independent gene wow colors, whether your actual optimal version of gene a will stay optimal or not. Speaker 3: (24:52) Or conversely, whether you thought you had the suboptimal version of a bad guy, you read the full story, something else tells you what you fought was the bad guy was not the bad guy. Wow. And this is what it's called at peace basis. You see we're all concerned about epigenetics, which is important. FP genetics. How are we reading? Are we actually going to read that paragraph on the page or are we not going to read? That's at the genetics, but nobody's talking about epi. Stacy, this is Stacy. This is often, we've read the page after we've read the paragraph. We cannot yet make a conclusion until we read 10 pages later, 15 pages later, something there. We'll bring it to life. We'll color what we read on page three. Speaker 2: (25:48) Yeah, so, so for example, if you're, if you're looking at a specific gene and it has an, that is say the faster for the sip, 79A1 gene and the hormone a kiss guide. If it's a fast one that's not in and of itself a good or a bad thing. It depends on the other things. It depends on the, so that's what you're meaning. So one of Speaker 3: (26:14) The best examples of that is this, the BDNF gene, the BDNF gene, brain derived neurotrophic factor. What are the most important genes in the brain? Well, in the whole human genome that tells the brain how to secrete this awesome thing that heals the brain. You and I were having a conversation about a loved one, so that loved ones B, D and F was going to be hugely important. And how that loved one recuperated from the challenge that she had met BDNF. Now the beating of gene has an important variation. A snip this time, which is either a G version or a version. Okay. TheG version, Jews and George as in guanine is the optimal version of BDNF, the optimal version. So if you're a GG blessed, that's good. You are naturally predisposed. You have the in Harrods, the innate ability to make more BDNF. Speaker 3: (27:13) And let me tell you that's a good thing. Any which way you slice it. Wow. An independent gene, the TPH to gene the trip to five hydroxylase gene to TPH, two gene, which is involved in how the body deals with serotonin. K two has a sip. It comes in a G version and a T version G as in George T as in Thomas. The G version is considered optimal but hold on. If you happen to be GG fatigue, pH two and GG for BDNF ostensively both those genotypes for each affair genes are optimal, but if you were GG for both, it creates a haplotype. It creates a combination that is an act risk combination and it is, it is the negative combination. It is the, it is the deleterious combination when it comes to certain aspects of human behavior. These individuals, when you're GGGG, they exhibit poor inhibition of negative emotional stimuli. Speaker 3: (28:28) In other words, when something negatively emotionally affects them, their ability to kinship, the ability to say, you know what, I'm not going to focus. I'm not going to hamster wheel constantly play that over and over over again. They haven't, they have a hard time giving up that when something gets under their skin. So to speak emotionally, they have a really hard time getting over it so they have a strong imprint. The memory imprint, very strong EMI, emotional memory imprint and of course the stronger you EMI emotionally memory imprints, the easier you emotional memory recall EMR is because the deeper something is imprinted then the smallest cue. You have a love, you have a partner and you know you love each other to bits, but like human beings, you're going to have your ups and downs. I mean it's where human beings after all, and on one particular evening you were both getting on each other's nerves and she was wearing that beautiful red dress and that was the evening that you both said things you shouldn't have said and it hurts the person who has this phenomena. Speaker 3: (29:36) Whenever he sees his wife, would that red dress down the road, everything's perfect. You, you're going up for a birthday party, you're both happy, it rises back up. He remembers that evening more than he should. It brings back to the surface and vice versa. This is that Paul, inhibition of negative emotional stimuli that lead to profound memory imprinting and therefore profound memory. Recall. The point of all of this and the reason I mentioned this is, and we're going to come back to the GSTT one, was to clarify, you see Lisa, it's not just about even the type of things you're looking for. What matters is the interpretation we sell the combination, we are reading the manual, not just flipping, picking words out. Speaker 2: (30:24) This is we have a calmer is well we are the, the apostrophes are this is someone that is what they would be more prone to PTSD Speaker 3: (30:36) 100 that's the point actually and that is further exacerbated based on the no adrenergic pathway which dramatically increases the risk of PTSD. It is exacerbated based on how quickly they are removing their dopamine and noradrenaline via content. So what happens is you begin to pixelate a picture and you've got a low resolution picture and then the more intelligence information you put in, you start to increase the resolution of that picture. You start to get a clearer picture of the person that you're looking at. But to do so, you've got to know where to pick slate. If I'm trying to get a better look at what Lisa's face look like, I don't really be pixelating your toes. I need to pick slick your face and this, this ability to read intelligently. Lisa, I stress intelligently. Riyadh, human genome. Yeah, that's what we do. We do Speaker 2: (31:35) That is absolutely insane. And they've vacations because yeah, I would have seen, Oh, you've got a G G G is good, but I've just understood that nuance, that combination of things. And now I can't wait to get my reports and my family reports so I could because this helps us also understand like the speed in which you are dopamine is processed and gotten rid off or the speed of which we're saratonin tone and all of these things have a fixed on your personality and that we're not 100% to blame for some of our differences. Speaker 3: (32:12) Oh gosh, no. Gosh, no. In fact, what this needs to do on the one hand, it creates the empathy of appreciating, look, this is how some of this is their predisposition. Now, on the other hand, it is not to create a sense of fatalism. While that's the way I am, I know I have found and I have done. The only thing that I've done, probably somewhat unique and special Lisa, is I have reviewed thousands upon thousands of profiles. In terms of my in the world, most of my peers that work at the level I do would say Dr. Mansoor Probably reviewed the most genomic profiles in the world. I don't know if that's true or not, but I certainly have reviewed several thousand meaning meeting the patient, speaking with their doctor, looking at their health profiles and looking at underlining genetic phenomena to see if we can understand what's going on. Speaker 3: (33:00) You know what I found, at least as a fellow, when you empower a person to understand a predisposition, you, you might think that leads to fatalism, but when you explain the functional reality, it actually does the opposite. It gives the person a sense of ownership and then they can finally say, you know, I have dumped with my entire life, I've been this way and I just, I didn't even know why it was that way. Now that I can even understand what's going on, it gives me some closure. Yes, but it now gives me something to appreciate. I can, I can envision how this is working, how my emotions are working. I can now go, you know what? As soon as I see that stimulus that would have got me on that slippery slope, I'm going to stop. I'm not going to go down that slippery slope because I know if I do, there's no coming back for the next two weeks. Speaker 3: (33:52) So what we've found is that this crew all around it just creates empowerment. Which brings me now to the question that you asked about GSTT one and you are, your connections are on point, Lisa, the connection between the detox mechanism of the body. Here's the threefold, and of course it's a bit more complicated, but it's also remarkable. You can take complex systems, break them down to building blocks and keep the acuity. So there are three building blocks we need to look at when we connect detoxification pathways in the body and the immune system. And the, the only thing missing is the inflammatory system. So the triangulation between toxins and immune responses goes like this. The human body's insulted with whatever. It's insulted with the intentional, the unintentional of our daily lives, those toxins enter the body or they try to enter the body. Step number one, how individually efficient is that person at negating bio transforming, neutralizing those toxins either before they can enter the body, such as in the mucosa of the lung, the alveoli lumen, the the lining of the lung, such as the GI mucosa and so on. Speaker 3: (35:16) And so what can we, can we neutralize it so the toxin doesn't even get into the bloodstream? And of course to the degree that it gets into the bloodstream, can we live a hepatic re detoxified so that at least it does not by you accumulate in the body so that at least it does not reach levels that are unsafe. First step number one now too, there are genes, there are whole gene families, their whole cellular processes, GSTs, glutathione, ionization, UGI, Ts, glucuronidation, methylation, self, phonation and acetylation. These are the major enzymatic steps linked to genetic genes that are responsible for bio transforming neutralizing things in our body, okay? So what we need to do is we say, what is the lifestyle environmental context of the person? What are they getting exposed to? I'll be living in a home that has written with mold, are they living and so on and so forth. Speaker 3: (36:17) Okay, step number one, step number two, how good are they at individually neutralizing those toxins so as to not bio accumulate them to the degree that those, whatever. The answer to that question is we're going to have an individualization and with some individuals are better at getting rid of toxins and others are not. If a person is not genetically, innately efficient, optimal at getting rid of their toxins, then what happens? Well, what do toxins do? Toxins cause cellular inflammation, okay? And they cause inflammation via any number of methodologies. They can inflame cell surface receptors, they can get into the cell and create overproduction of oxidants as they can hamper the energy modules, the mitochondria. That's one of the places you'd never want toxins getting to. And of course they can get into the nuclear eye. They can get into the libraries of the operating manual and they can start to change gene expression. Speaker 3: (37:23) So toxins do all of these things. Ultimately, you see Lisa 15 not even 15 years ago, 10 years ago, if you told that a medical conference, there's this concept of inflammation. You'd have a lot of professionals. Well, come on, you gotta be more specific than that. We actually now know that there is a phenomena called chronic inflammation, and regardless of what stimulated that inflammation, bat bacterial toxin B, it's an inorganic chemical. It be it a physical inflammation. It does not matter the way the sun looks, the way the cell begins to behave when it has been insulted with toxins, with exposures, remarkably is the same regardless of the stimulus. Because chronic inflammation has hallmarks that are similar regardless of the stimulus. Now at that juncture, when the cell is inflamed, when the machinery in the cell isn't doing the job that it's meant to do properly, that cell now starts to be like this pulsing red thing just by analogy. Speaker 3: (38:35) In other words, the body is looking at it going, something's happening in there. It's not behaving the way it should. Okay, so now we're going to have two steps. The body now has an anti inflammatory set of steps to quiet us, to bring the cell back into line cause they Whoa, Whoa, hold on. You're starting to misbehave. There's too much inflammation. This is where it's selling the process known as methylation comes in. Cellular methylation can be viewed. It's a detox reaction by the way, but it is a cellular cascade that is radically responsible for bringing your soul from that humming, inflamed, you know, ticking bomb type of modality back down to acquire essence behavior. That's cellular methylation. Now, to the degree that you're able to do that, because suddenly methylation is a multigene cascade, multiple places where things could be not as optimal as we would like. Speaker 3: (39:36) So to the degree that we then triage, we stratify the patients based on their detox potential. We then stratify them based on their anti inflammatory potential. Now, to the degree that we are not quite yessing that chronic inflammation, this is where the immune system can be activated. Immune system was meant to be activated in acute episodes, not chronic episodes. The more you ask the cell to produce antibodies, IgG, IGA is IGMs, particularly IgGs. The more you keep telling that the body pump out IgG, something's not working right, something is there, which is why chronic infections are now very well understood to be linked to autoimmune diseases. The infection did, did not go away, constantly demanded of the body to produce antibodies. And somewhere along the line those antibodies begin to forget what was the bacteria or what and what was the self. And now we just start shooting friend and foe alike. Wow. This is the triangulation that has become now a focal point of so many diseases. Some diseases being more relevant to the whole, you know, things like lying disease. Do you guys have lung disease down in New Zealand? Speaker 2: (41:05) I think, yes, we do. And I think you know we have a massive problem with like thyroid, Hashimoto's sort of autoimmune diseases, crones, IVs. So this is, this is where the body is actually going in overdrive. So the, the original detox genes haven't been able to do their job because combination. Speaker 3: (41:26) There's that one. Exactly. There's inflammation. Yup. Speaker 2: (41:33) Yes. Speaker 3: (41:33) Methylation didn't do the job that was supposed to do and now we're triggering. So there are meta-analyses meta-analyses that show the deletion of the GSTT one gene or overall poor Ghouta finalization has been strongly linked with ulcerative colitis, Crohn's disease, IBD, strongly linked with ectopic asthma, particularly GSTP one in early childhood asthma. Then of course, if you, if you double down on poor math on poor detoxification with poor methylation, you really start seeing Speaker 2: (42:10) Clinical outcome. Yes. Yeah. So, so if we then we, we, we find out all this about ourselves. We find out we've got either the good or the bad and the ugly. And these combinations are not ideal. Then how, you know, we've got this information now, now we want to know what the heck do I do about this? I can't change my DNA. Of course, all things that these reports that your company does, for example, where it can actually lead to some successful outcomes. Obviously avoiding cigarette smoke or exhaust folk tunes and things your GPS deleted. But, but beyond that, nutraceuticals, new nutrients what can be done to help people. Speaker 3: (42:52) So it starts with, so the first thing I would have to say is we take our reports only so far. So the actual report, we take it to the point of explanation of what's happening. And there are certain recommendations, but the real magic must still come from a trained population, you know? So what, so what we do is through also training a certain class of healthcare providers. We might call them the, the new modern day biohackers. The healthcare providers who are really sniff, they're no longer just, you know, pill pushers. They're looking. So I just wanted to clarify. We take the reports, we explain the systems, we explain what's happening, but we also have to be careful so that people aren't jumping to conclusions and self-treating based. So you still want to have someone who understands the bigger picture. And by the way, that's the second part of what our company does. Speaker 3: (43:47) As per my travel schedule, I'm constantly traveling, teaching people, teaching auditoriums full of doctors who are now saying, listen, if I keep practicing medicine the way that I'm practicing, I'm just dealing with a disease population. I'm not healing people. Okay, so with that minor clarification, now we come to, let me paint a picture, paints a thousand words not to be, you know, blahzay here's what I like people to picture and here's what you would want to picture for yourself. Lisa. Picture slide. Okay, so there's a slide your screen, okay, and a circle. And then picture a circle on that screen somewhere on your screen. There's a circle. Now because you're a human being, your circle is going be on the screen. In other words, this is the screen of all human beings and your circle, you, your circle is somewhere on the screen or what does the circle represents? It represents your genetic makeup, which represents a part of your genetic makeup for whatever biochemical process we were studying. So this circle is Lisa's genomic pathway. Okay. Speaker 3: (44:56) I want you to then think of an equilateral triangle that equal three sided triangle that just perfectly encompasses your circle just perfectly. Your circle is perfectly encompassed just right in that triangle. And the emphases of this triangle are labeled environment, lifestyle and nutrition. Yes. What we're learning and what we're recognizing more and more is other than extreme cases, other than extreme cases, and there are mind you extreme cases where a particular genetic combination was really just a real doozy. And in other words, we're going to see some, you know, with the best of efforts, we're going to see some probably deleterious outcomes. Fair enough. But other than those extreme cases, for the vast majority of us, the spite, any inefficiencies we might have if we find the right triangulation of lifestyle, nutrition and lifestyle, nutrition and environment. If we could figure that out and it perfectly matches, I would circle. Speaker 3: (46:08) This is optimal health. So image, the image of optimal health is when you can find your genomic makeup, your circle for whatever you're studying and contextualize it perfectly within the right for you. For Lisa Laughlin, sir, not for Joanne Felisa. What is leases? Optimal lifestyle, nutrition and environment. Now the problem is, Lisa, when we begin working with a patient, obviously and clinicians with their patients, the vast majority of individuals, they do not know their circle. They don't know what's the economic influence. So they don't, and if you don't know your circle, your triangulation, choices of lifestyle choices, nutrition choices, and environmental choices offers skewed and they are not synergistic with your circle. So first objective of this, did you get that picture? Do you know when people say, well, it depends on your genes, your genes. It depends on how you're using your body. If you are, if you took, if you took five identical individuals, they were, you know, quintuplets identical, contemplative. Speaker 3: (47:27) If such a thing exists in today, the same genes and you give those five people at 35 years old, the exact diet. But if those five, one of them was an ultra marathon runner and extreme sports enthusiasts, the other was a couch potato, I don't know, doing whatever the other was a, you know, an accountant who had a nine to five job. We can exercise worrier, but from Monday through Friday really just goes to work, comes home, eats, goes to that and so on and so forth. Even with the same jeans, you can put the nutrition and an obviously not expect the same outcome because they got to know the genomic legacy. You've got to know what is the lifestyle context, what is the nutritional context, what is the environment or context? If one of the things quintuplets moved from your gorgeous country and move to massive metropolis with, you know, air quality, that breathing for one day is the equivalent of smoking a pack of cigarettes in your beautiful country. Speaker 3: (48:36) He or she may have gotten away with a GSTT one or GSTP, one suboptimal ability. He's living in those, you know, that wonderful country views. He's practicing otherwise good, not eating foods with pesticides and herbicides and so on and so forth. And he was going about life actually, not really realizing there was any suboptimal ability until one day his job took him to a big metropolis somewhere. He lost track of the quality of his foods. He's just so busy. He's day in, day out breathing the equivalent of a pack of cigarettes and then six months into this, all things ELLs as equal, his jeans are equal, but he now starts to show symptomologies that he would never have had any different environment and a nice clean environment. Right? So this triangulation is so important. Now coming back to the specifics, once we understand the pathways, we begin first with the dose. Speaker 3: (49:31) It may seem simple, but it actually enters Lisa into, it's not just about the obvious things that you might imagine. I give the example, Lisa, and by the way, it's relevant to the GSTT one gene. Now, juice, TT. Let's focus on the T one. It's the big sister in the glue, the fine fabric. So GSTT one no, it's what's called a phase two detox pathway. Phase two detox. Because when it talks and enters the human body, we typically go through two steps. We take toxin a, we converted into an intermediate B. Yup. We take B further, convert that to C. C is what leaves the body, the B to C part of the transformation. That's where the GSTs come in. The a to B. This is where your cytochrome P four 50s come in. That's the phase one. Bio transforming enzymes. Now if I were to ask you something, when you say fiber to say, would it be a good practice for person to start drinking a nice cup of green juice? Speaker 3: (50:38) You know, like some juice, juice, broccoli and some maybe put a little bit of a baby spinach in there. A bit of ginger, maybe some cute, cute curcumin at the end of it. Would that be a really healthy drink? Yes. Something I do every day. Beautiful, beautiful. And it is healthy generally speaking. So now someone puts a blog together giving this recipe of something that's ostensibly so healthy and there's this mechanic who works in a shop all day with fuse and so on and so forth. He read this blog, she read this blog and she decides that before she goes to work, she's going to have this beautiful juice. This green juice that they read was so healthy and it was a detox juice and they feel good about themselves. Hold on, hold on. Many of the ingredients and not green juice. Many of the ingredients in that green shoes turn on certain phase one sip four 50 enzymes so as to accelerate the conversion of a to B. Speaker 3: (51:54) Now some of the toxins a that this mechanic was facing in her shop, in the, in the, in the mechanic shop that she was working at, when she converts a to B, we know that the B, the intermediate is truly more toxic than wow. And by the way, she did not know she was a GST one deleted individual. Oh, so what did we do to this young woman? We encourage the things that is that we're getting into her body. When she drove that beautiful healthy green juice, she more rapidly converted her A's into B and then ups B's and to CS very well. Wow. Even something that would ostensibly be really healthy by normal standards. Do you see that's a healthy nutrition on the triangle, but we did not ask what was the environment on the triangle and so now we have skewed her triangle away because her genetics circle, she does not have the GSTT one. Do you get that picture? This is a little bit frightening for people who are listening to this or who might be going well, what's the point being? Speaker 3: (53:16) This is weird. The reports have the super value, isn't it? That's the point. It's, it's actually not discouraging. It's, it's finally, and this is all gold. It's finally meant to unravel those nuances that there is such a thing. Have you been? How many of us, you know, we do something that 20 or the coworkers swore was the best thing since sliced bread and then we tried it and not only did it not work, we actually felt like crap or less healthy, and we, we're all aware of this until it's what is it led? It's led for most of us to become numb. We're just kind of get to that point where we're like, well, I don't know what's right for me or run for me. Plus today it says one thing tomorrow it says another thing. So creating some sanity from this confusion is what this goal is about and it can be done. Speaker 3: (54:11) Lisa, when you take your time to read things, intelligent meals, explain things. That's why we've got these epiphany moments that constantly, I like my consults with patients because I feed off of the energy. When a patient just, you see that epiphany admission and they light up and they go, Oh, that's why this hasn't been working with. That's why that was better for me. That's why I took methyl B12 because everyone's telling me methyl B12 is the best version. But every time I take methyl B is it just in my head. I get a headache every time I take micro B12 I get a, and then I go, no, actually I got one too. I can't take methyl before. That's an actual thing. I can't take methyl B12 because my methylation cascade is inconsistent with me taking methyl Beto when I take a dental Sobe 12. Oh, completely different. Speaker 2: (55:07) Wow. So this is getting really granular for each individual. And this is what makes me so excited. And, but before we go on, we have to go and cover off the hormone report. This is something that I and, and this is, you know, for me and any woman, but I wanted to focus a little bit more in on the woman. We've got very complicated hormones, households, but this was the cascade for men and women is very, very similar, isn't it? Yes Speaker 3: (55:33) It is. It's just remarkably, this is what we taught at the cost on the weekend after introducing genomics, it was the first open to eyes that the cascade, the circadian rhythm with which the human body converts progesterones into androgens, androgens to estrogens, men, we do not have a monopoly over androgens. Women, you do not have a monopoly over estrogens. In fact, your estrogens come from androgens. Men, we have estrogens. It's just a matter of the circadian rhythm. When is it happening? How quickly is it happening? And of course, ultimately how much of any of these hormones are produced. And then the final component is how responsive are you, the the woman's body, all things equal. She's designed with the estrogen receptors to be more responsive to estrogen. She responds to androgens as well. Conversely, for men. Now keep in mind something as simple as, I can't believe how many clinicians do not realize how an androgen or estrogen receptors. Speaker 3: (56:32) Now let's stop there for this cascade. We can talk about all of the things about how hormones are produced and how they're metabolized and so on and so forth. But ultimately, how is estrogen affecting your body? Lisa, you're a young woman. You're making estrogen as if you're menstruating or if you want hormone replacement, there's likely some estrogens in your body, one way or the other when estrogen binds to your estrogen receptor. And to the degree that that can happen, mind you, because there are variations to that fidelity, this complex estrogen. So the estrogen receptor androgen to Stastrom, DHT to the androgen receptor. These complexes are some of the most potent DNA transcribing complex. They go into the nucleus and the churn on genes. This is how estrogen and testosterone impacts the human body. They live. They're not just, I don't know, causing breast development or, or, or, or Andrew demise in the book. Speaker 3: (57:39) They do that by churning on the genes that cause the cells to behave in a more underutilized manner or more estrogen. So the first thing I want, our audience needs, our clinicians, we need to re re climatize reacquaint ourselves with that. These hormones potently DNA transcribing, they go into the nucleus and they turn on and off genes. That is why they are not to be dealt with trivially. Number one. Number two, in a menstruating woman. Now I just told you when estrogen enters a cell, I did binds its receptor. It's not just staying in the, in the Maloo of the South, it's going in to the volts, the nuclear volts and churning on and turning off genes. Wow. When you look at the ministerial cycle of, of a, of a relatively normal, repeatable menstrual cycle, you will notice something radically important over the course of 28 days. Speaker 3: (58:43) The human female body isn't exposed to estrogen at the same amount every day, not at all. The human female body in 20 days only has about a six day or so window in which your estrogens that are really elevated and then it comes down. In other words, what is this telling us from a human biology perspective? It's saying that the type of gene expression changes the epigenetic phenomena that estrogens cause on your operating manual. You don't want that to be consistent and constant across the month, and this is very frightening when you look at contraceptive pill or hormone replacement therapy. So it's most certainly very frightening. That is not, let me be clear. That is not to say that there isn't a place or a time for these things. You know they are absolutely a young woman has to have the right to how she treats her body and what she does. Speaker 3: (59:47) But there is a place in time you at least be equipped, at least be empowered before you make this decision as to a knowing what it's doing for you. Say, okay, look for these few months of my life, for these couple of years of my life, this is going to be a bit more important that I take these precautions, for example, but you should know that to do so indefinitely, month after month, year after year. Now they've got clinicians encouraging young woman not to even have a bleed through. There's no point for even the bleed. So just stay on the, you know, constant level, 24 seven three 65 15 years. How is this compatible with normal human physiology? When you understood what I just said? Yep. Now let's go a step further than that. You see estrogens do what we just said. They bind their receptors, they go into the cell so they go into the nucleus. Speaker 3: (01:00:47) They change gene expression as they're meant to for brief periods during the month. Fair enough. Now, once those estrogens have done what they've done for those days, then the point of it is there's a circadian rhythm. The body breaks down those estrogens metabolizes them by a transforms them so that they're no longer active. They've been neutralized, and then we hit repeat, rinse and repeat, and we start a new cycle. But here's the point. Every a woman, Lisa, every a woman, a man for that matter, but let's focus on the ladies when she made her estrogens or she took her estrogens, because even whether you take it or whether you make it innately or you take it, it doesn't matter. You've got to metabolize the estrogen. Now, every young woman can metabolize estrogens into three byproducts. I estrogen 400 Z estrogen, 16 hours for hydroxy estrogen. Every human being does this, and this is a crucial point. Speaker 3: (01:01:49) Absolutely. But these three metabolites do not impact yourselves in the same way you say. If you thought of it, you've made the estrogen small window. Now you want to neutralize it so that the body isn't under its constant influence. So you want this metabolite, this estrogen, this hub light to have lost bind to the receptor. You want it to last. It's estrogen Ising properties. Lo and behold, four estrogen, one of those three metabolites retains the ability to bind the estrogen receptor. In fact, some studies show it might be an even more potent comm when it, when it binds and it creates this, this common, a tutorial, Leiden and receptor, it's DNA. Transcribing effects are even more potent, much like the analogy between DHT and the androgen receptor versus testosterone. DHT dihydrotestosterone, which is a metabolite of testosterone, has a higher potency binding affinity to the androgen receptor. Speaker 3: (01:03:00) Four hydroxy estrogen is to the estrogen receptor as DHT is to the androgen receptor. Wow. The ability innate tendency of a young woman when she's faced with estrogens to make either the two hydroxy which is considered protective because has lost or the four hydroxy that inmate differentiation is radically genetically determinable. Now, if something as simple as that, Lisa, when you stitch these things together, when you understand, look, estrogen should be my body needs security and rhythm. I do not want estrogen is constant. When I break down those estrogens, I want my body to have had a break from them. And you did not know whether you were four hydroxy dominant or not. If you had a tendency to make more of the four hydroxy than the two and why is four hydroxy so naughty? Three reasons. A, it binds the estrogen receptor, not giving your body a break from the estrogen ization one to four hydroxy estrogen if you are not flushing it out of the body and how do you flush out for drugs, the estrogen through methylation, the comp gene, which is catechal methyl transfers an oops. Speaker 3: (01:04:29) Can you imagine if you were innately genetic info, hydroxy dominant and have the slow comps because now you're making too much four hydroxyestrone you have a tendency to do so. You do not have the enzymatic ability to get rid of it. Now you buy your stagnate, your four hydroxy Astrid. Do you know what full hydroxy estrogen does other than binding the estrogen receptor and Quinones? Quinones? Listen, my God, you're speaking more than some of the best medical biologists that I've spoken to. So the, the decompose into Quinones and do you know what Quinones do? They get into your DNA. They stick to, they are mutagens. They stick to your DNA, causing the DNA to not be able to unravel and repair itself and by the Quinones then cause accidents. So here's what you don't want to be. You don't want to be the young woman who is genetically predisposed to overly produce four hydroxy estrogen simultaneously, have a poor comp, simultaneously, have a low GSTT one GSTP one, which was the thing, Quinones, and then have a poor mitochondrial superoxide dismutase or antioxidation to get rid of the oxidants Speaker 2: (01:05:52) And add to that. You're in your forties or your 50s and you're making more EstroZen, Speaker 3: (01:05:57) Which is a breast tissue because it's not in the liver anymore. The liver organ, at least it was designed for that type of metabolism. You're doing this in the breasts, you know, God forbid. Okay, Speaker 2: (01:06:10) This is where the cancers can come in Speaker 3: (01:06:13) This is weird and just why we have the the epidemiologic rise during that shift where the woman's body shifts from doing that grunt work in her liver, which was designed for it to doing that grunt work in such as breast tissue, cervical tissue, an ovarian tissue and so on and so forth. Which of course the human body, the female body does not express estrogen receptors, the same level for every cell type. You know, when you were, we lobby at nine years old and you could have gone outside, you know, flat chested like any other boy and you know, and then when, when men awe kits and the body changed your elbows and forms didn't change, it was suitable zone. Those are the zones that have more estrogen receptors. Speaker 2: (01:07:03) And this is so this is how we can see like when you're looking at the phenotype, if we can go look like the the the hormone cascade just for people that are listening, it's going from producer owns and pregnenolone's into testosterone's which can sometimes go into DHT and which then go into the estrogen. Is thrown in your estradiol if you're pregnant when you're older you have more strokes coming in which are, that's coming from the the other top of testosterone isn't it? One on one and then it's means a lighter than these three path rates into the two hydroxy four h

In this retail podcast, meet Dhruv Toshniwal, the Vice President of Business Development at Banswara Syntex. A 43 year old family business built out of Banswara, a town in Rajasthan in India, Banswara Syntex Ltd. is a global textile manufacturer that specializes in the production of yarn, fabric and garments. They deliver the highest quality dress-up clothing to some of the best global fashion brands in the world including Ralph Lauren, GAP, Next, Levis, M&S, Raymond, Nordstrom, Arrow, Banana Republic and many others. Before he joined his family-run business, Dhruv graduated from The Wharton School in Pennsylvania, USA where he specialised in finance and information management and worked in financial services consulting at Oliver Wyman, Gentera and Banco Compartamos. Listen to The Vue Podcast to find out how he's solving retail's biggest problem - the supply chain. Tune into the Vue Podcast to find out  how production processes at Banswara are being optimised for faster lead times without compromising on quality, where the future of fashion is headed and how they plan to leverage the best technologies in the world to make effective supply chain management a reality. If you're someone with a deep interest in sustainability - this is a great episode for you! He also covers all of Banswara's sustainability efforts in depth - whether it's reducing water consumption, using recycled synthetics or making production more efficient. Here's the transcript, to make your experience easier: https://vue.ai/blog/podcast/the-vue-podcast-leaders-in-retail-dhruv-toshniwal/

Dr. Paul Cannon is the Parkinson’s Disease Program Manager at 23andMe. Paul and the team at 23andMe are working with patients, genetic data, and other self-report data to understand genetic mutations linked to Parkinson’s disease, disease risk factors, and other comorbidities experienced by people with Parkinson’s disease. Outside of work, Paul enjoys traveling to visit new places in countries or parts of countries that are not necessarily considered typical tourist destinations. He also likes to hike, watch cricket matches, and watch Premier League Soccer games. Paul received his Master’s degree in Natural Sciences from Christ’s College in Cambridge and his PhD in Medical Sciences from the University of Calgary. Afterwards, he worked as a Research Scientist at Syntex. Next, Paul spent nearly 15 years in various roles at Roche Pharmaceuticals and Genentech. He worked as a Senior Consultant for Tynan Consulting for about four years before joining the team at 23andMe. In our interview, Paul tells us more about his life and science.

In our final episode of season one, Professor Gabriela Soto Laveaga explains the central role that Mexico played in the creation of the birth control pill -- a history that has often been told about a few people in the US. From Ernesto Miramontes, a Mexican scientist whose name is on the patent for a compound used in the first oral contraceptives, to Syntex, the company co-founded by chemist Russell Marker in Mexico City, Mexico takes center stage in the history of oral contraceptives. But what about the hundreds of thousands of peasants in the South of Mexico, who dug up and even manipulated the barbasco roots from which steroid hormones were being synthesized? And are the dense jungles from which they found and dug up tons of these wild barbasco roots a laboratory? Audio credits: Thanks as always to The Overseas Ensemble, a collaboration between composer Paed Conca and Sarigama, for use of their music

After two years, Glidden abandoned production of cortisone to concentrate on Substance S. Julian developed a multistep process for conversion of pregnenolone, available in abundance from soybean oil sterols, to cortexolone. In 1952, Glidden, which had been producing progesterone and other steroids from soybean oil, shut down its own production and began importing them from Mexico through an arrangement with Diosynth (a small Mexican company founded in 1947 by Russell Marker after leaving Syntex). Glidden's cost of production of cortexolone was relatively high, so Upjohn decided to use progesterone, available in large quantity at low cost from Syntex, to produce cortisone and hydrocortisone. In 1953, Julian founded his own research firm, Julian Laboratories, Inc. He brought many of his best chemists, including African-Americans and women, from Glidden to his own company. Julian won a contract to provide Upjohn with $2 million worth of progesterone To compete against Syntex, he would have to use the same Mexican yam Mexican barbasco trade as his starting material. Julian used his own money and borrowed from friends to build a processing plant in Mexico, but he could not get a permit from the government to harvest the yams. Abraham Zlotnik, a former Jewish University of Vienna classmate whom Julian had helped escape from the Holocaust, led a search to find a new source of the yam in Guatemala for the company. Information Sourced From: https://en.wikipedia.org/wiki/Percy_Lavon_Julian Body Sourced From; https://youtu.be/KSq__sdYNNk Public Access America 
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In this episode: A friend's Friend with Benefits is dropping hints that he may want to be... actual friends? How should one respond to a completely decent proposal? Should she let this grow, or nip it in the fuckbud? The Guy Friends remind you that they have personalities, too, ya know!!! And a listener is going out of town for a few months and wants to leave her own FWB with temporarily-parting gift. But what do the Guy Friends think of the gift of pornographic materials? Would it be uncouth for our listener to expand her lover’s spank bank? Wouldn’t a nice card, or a modest Edible Arrangement suffice? Good Die Young (Kesha x Owl City ft. Carly Rae Jepsen x Flo Rida) (SYNTEX) CC BY 3.0