Podcasts about act ii

Ricky Ian Gordon has written a cycle of songs about flowers. In this episode, we hear one of them. Rachmaninoff wrote a song called “Lilacs.” We hear that, too. Bach opens his Goldberg Variations with an aria (and closes the work with that same aria). Tchaikovsky's wrote a couple of blockbuster arias in The Queen of Spades. And on we go. Gordon, “We should not mind so small a flower” Rachmaninoff, “Lilacs” Bach, Goldberg Variations Tchaikovsky, Lisa's Aria from Act III of “The Queen of Spades” Tchaikovsky, Prince Yeletsky's Aria, Act II, “The Queen of Spades” Tchaikovsky, “It was in early spring” Shostakovich, Prelude in D-flat major Bach-Kempff, Siciliano

" I went to see CATS about five times with notebooks and took notes throughout the performance." This episode features Caesar Samayoa who performed as the Rum Tum Tugger in an "illegal" high school production of CATS in New Jersey and is currently performing as Don Kirshner and many more characters in Just In Time on Broadway. Hear Caesar dive into his fascinating journey from performing in multiple Cats productions, including the alleged 'illegal' high school version, to his current role as Don Kirschner in the hit Broadway show Just In Time. Cesar shares amusing anecdotes, behind-the-scenes stories, and insights into the immersive world of theater. They also discuss the deep relationships between characters on stage casting CATS into the world of Just In Time. Whether you're a CATS aficionado or new to the theater world, this episode offers a delightful mix of nostalgia, humor, and genuine passion for performance. 01:01 Illegal High School Production of Cats 04:28 Regional and Broadway Auditions 07:56 Performing in CATS 13:31 The Depth of CATS Characters and Relationships 22:04 Just In Time on Broadway 23:08 Just In Time Immersive Theater and Audience Reactions 27:02 Casting CATS Characters in Just In Time 33:24 Rapid Fire Check out Caesar on Instagram: @caesarsamayoa Check out Just In Time on Social Media: @justintimebway Check out Just In Time on Broadway: justintimebroadway.com Produced by: ⁠⁠⁠⁠Alan Seales⁠⁠⁠⁠ & ⁠⁠⁠⁠Broadway Podcast Network⁠⁠⁠⁠ Social Media: @⁠⁠⁠⁠TheWrongCatDied Learn more about your ad choices. Visit megaphone.fm/adchoices

Vi sitter på Åbytravet med Dun Ringill.Bandet bildades 2017. Bandet spelar progressiv doom metal.Den 14 mars så släppte dom Act II av plattan "Where The Old Goods Play".

Author's note: This is my apparently-annual "I'll put a post on LessWrong in honor of LessOnline" post. These days, my writing goes on my Substack. There have in fact been some pretty cool essays since last year's LO post. Structural note: Some essays are like a five-minute morning news spot. Other essays are more like a 90-minute lecture. This is one of the latter. It's not necessarily complex or difficult; it could be a 90-minute lecture to seventh graders (especially ones with the right cultural background). But this is, inescapably, a long-form piece, à la In Defense of Punch Bug or The MTG Color Wheel. It takes its time. It doesn't apologize for its meandering (outside of this disclaimer). It asks you to sink deeply into a gestalt, to drift back and forth between seemingly unrelated concepts until you start to feel the way those concepts weave together [...] ---Outline:(02:30) 0. Introduction(10:08) A list of truths and dares(14:34) Act I(14:37) Scene I: How The Water Tastes To The Fishes(22:38) Scene II: The Chip on Mitchell's Shoulder(28:17) Act II(28:20) Scene I: Bent Out Of Shape(41:26) Scene II: Going Stag, But Like ... Together?(48:31) Scene III: Patterns, Projections, and Preconceptions(01:02:04) Interlude: The Sound of One Hand Clapping(01:05:45) Act III(01:05:56) Scene I: Memetic Traps (Or, The Battle for the Soul of Morty Smith)(01:27:16) Scene II: The problem with Rhonda Byrne's 2006 bestseller The Secret(01:32:39) Scene III: Escape velocity(01:42:26) Act IV(01:42:29) Scene I: Boy, putting Zack Davis's name in a header will probably have Effects, huh(01:44:08) Scene II: Whence Wholesomeness?--- First published: May 29th, 2025 Source: https://www.lesswrong.com/posts/TQ4AXj3bCMfrNPTLf/truth-or-dare --- Narrated by TYPE III AUDIO. ---Images from the article:

India's renewable energy capacity has reached 220 GW, but can the country stay on track for its 2030 targets? In this episode of Unusual Suspects, Saurabh Kumar, VP–India at the Global Energy Alliance for People and Planet (GEAPP), talks about what it will take to scale clean energy, unlock capital for startups, and drive the next wave of innovation. From the rise of ENTICE 2.0 to the challenges of climate tech funding, this is a ground-level view of India's clean energy moment, and what could define the decade ahead. Tune in.

In this episode Rachel is joined by her friend Hannah! Hannah has had a lifetime full of dating stories. Hannah tells Rachel the story of how she met her late husband and about the beautiful marriage that they shared. Hannah then tells Rachel the stories of her dating adventures as a widow, and we thought the first time around was bad enough! We are just waiting for the day that the stories end and Hannah gets her chance at an Act II! This is definitely and episode you don't want to miss! Shticky Situations is sponsored by CoronaCrush. To find out more information about CoronaCrush visit their website and coronacrush.co. Also join the CoronaCrush Facebook group and sign up for speed dating events!Remember to like the Shticky Situations page on Facebook, follow @shtickysituationspod on Instagram, and follow @shtickysituationspod on Tiktok! And make sure to join the Shticky Situations Loop Group:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://loopmein.app.link/invite?uuid=7bd5252c-c1ff-47fc-938b-1c319c57354e⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Want to be a guest and hang out with Rachel and discuss your own dating stories? Apply today https://forms.gle/FhwZs74JBTJgGpw8A! Want to try your luck at dating Rachel or any of her guests? Also apply today https://forms.gle/J31HUQ5aYTzjz5Bv6! You can also send an email too shtickysituationspod@gmail.com or DM @shtickysituationspod on Instagram. Serious inquiries only.Shticky Situations is sponsored by Primrose Flower Shoppe! Primrose is located at 2922 Avenue M, Brooklyn, phone number 929-376-9815, and follow them on Instagram @primroseny.

Another fantastic chat with Wayne Shields-Hogue from Playhouse in the Park. We explore deep conversations about the summer productions and the Penguin Project. And this time, he nails the Lighting Round!

Orlando, from the play As You Like It, talks about church bells knolling, and later in that same play, the Duke talks about how we “have with holy bell been knoll'd to church.” There's a conversation in Act II of Pericles where two fishermen discuss a parish getting swallowed by a whale, and they refer to the parish as “The whole parish, church, steeple, bells, and all.” These references demonstrate the important cultural place of bells in England for Shakespeare's lifetime. While Moses is credited with introducing bells to Jewish religion, Italian monks are given credit for introducing bells to Europe, with Saint Bede bringing them specifically to England when he introduced their use in funerals around 700 AD. By the time of William Shakespeare, metallurgy and construction had experienced a metamorphosis, with churches in Europe adopting not only intricate design, but seeking to increase both the size and the sound of their church bells. Here this week to tell us about the history, size, shape, sound, and technical process of building a church bell in Shakespeare's lifetime, is our guest Guthrie Stewart  Get bonus episodes on Patreon Hosted on Acast. See acast.com/privacy for more information.

In the show's 35th episode, we are super electrified to have designer Kaleb Wentzel-Fisher join us and to talk about Power Vacuum and so much more. The stories here might shock you! The puns I force Kaleb to make might make your hair stand on end! That's all a part of the guarantee that you are in for a more fun time than a stroll down the aisle of your local appliance store.But in all seriousness, this is a great episode. You already knew that.Check out Kaleb's work:WebsiteBlue SkyPower Vacuum (purchasable through Keen Bean Studio)[The intro kind of forgot the number initially, making things sound a little funky–but that was corrected shortly after–lol.]NEW SHOW NOTES FEATURE–Google Doc of Games Mentioned this EpisodePrologue (0:00)Several fun introductory anecdotes, and Kaleb is set up with a task that will help “set the scene” for each of the following acts.Act I (18:30)Exploring Kaleb's backgrounds in film and sound in order to see how they have made their way into Kaleb's board game design thoughts. Kaleb and Malachi Ray Rempen (Keen Bean Studio) have a very interesting backstory, and Kaleb reflects on that here as well.Act II (48:11)Some quotes taken from The Death of Stalin, an inspiration for Power Vacuum, and some random questions based on those quotes.Act III (1:15:16)What constitutes an appliance?How did Power Vacuum come to exist?What is the meaning of life?Two of those three questions are answered.Probably.Epilogue (1:41:26)A text on Kaleb's mind and things to look out for from him in the future.-----------------------------------------------------------------------------------------If you like this show, liking it on whatever platform you listen to and writing a review would mean so much! Furthermore, it's as independent as it gets, so any financial support would help with the subscriptions that make this project go smoothly. That can be done here: Buy Me a Coffeevodthepod@gmail.comBlueskyInstagramTikTokOversized Sandwich BGGOversized Sandwich (to purchase)

After some quick news bits this episode is all about Clair Obscur: Expedition 33 and some of our issues, things we love, and spoilers up to after the first Axon fight in Act II.Here are the timestamps:Intro News Bits- 00:20 Clair Obscur: Expedition 33 Updated Sales- 04:19 Split Fiction Sales Figures- 04:43 Switch 2 Game News - 08:22 Alien: Rogue Incursion Non-VR Release- 09:22 Gears Of War Reloaded Coming To PS5- 13:21 Fallout Season 2 Wraps Filming- 14:56 CD Projekt Red CEO Speaks Out For Physical ReleasesWhat We're Playing- 27:15 Clair Obscur Spoiler Talk Up To The First Axon.

I. The Act II. The Motivation III. The Defense Scripture Reading: John 11:55-12:19 Text: John 12:1-8 Psalter Numbers: 251, 392, 113, 311

Beyoncé kicked off her Cowboy Carter Tour here in Los Angeles this week, and I had the opportunity to attend the opening night and the second show! Let's recap everything from costumes, visuals, set lists and the artist paying tribute to those who came before her. Support me on Instagram @jamir_smith and jamirsmith.comfor the latest events and experiences.

In this episode, Dave and Andrew talk about a curious winner for the year 2000 since it was originally composed 25 years earlier! What will they think about this blast from the past? It's also the first opera to win the Pulitzer Prize in many decades.   If you'd like more information about Lewis Spratlan, we recommend: This video of Spratlan talking about the origins of the opera before the full premiere by the Santa Fe Opera. This video of Spratlan detailing the opera's history with the Massachusetts Cultural Council. A. Robert Lauer's article "The Santa Fe Opera's Life Is a Dream" Bulletin of the Comediantes, Volume 63, Number 2 (2011): 155-60.

Former champion boxer John Duddy from Derry and one-time construction worker Newry's own Ciaran Byrne share their unlikely paths to acting on stage and in film in part two of our first live podcast recording for Origin Theatre's 1st Irish Festival.The two friends delve into how their life experiences inform their performances, personal traumas from The Troubles, and the critical role of theater in post-conflict healing and education. Sharing compelling narratives throughout, Ciaran and John underscore the significance of their Northern Irish roots and the transformative power of storytelling, but don't stint on the Irish craic.Massive thanks to Origin's Theatre's artistic director Mick Mellamphy (who we featured in this 2023 episode) for envisioning our live podcast event and curating our stellar guest list, to the Northern Ireland Bureau for their generous support, to Bill Schultz for recording and editing the episodes, and to Jimmy and the crew at Ryan's Daughter for their above-and-beyond hospitality.LinksCiaran ByrneWebsiteIMDbXInstagramLinkedInFacebookJohn DuddyIMDbInstagramFacebookLinkedInOrigin TheatreWebsiteThe Northern Ireland BureauWebsiteEpisode Details: Season 7, Episode 15; Total Episode Count: 118

Send us a textNancy is in wrapping up "Act II" of her life journey. Act I was living in Ohio and working in HR in the corporate world. Act II brought her to the beaches of NC to become a CTE teacher at Jacksonville High School. With a few decades of teaching under her belt and only a few years left until retirement (Act III), Nancy has been gazelle intense, working on having her financial house in order as she gets ready to ride off into the sunset and travel the world as a part of her final act. Nancy first appeared on FIT last year on episode 159 (check that out to hear more about her personal story). Since then, she has officially become a net worth millionaire and is helping others along the way! 

Off the Golden Path... We re-join Rozhok and Dr. Ziggy huddled in the wreckage of a House Borgene vessel, desperate to survive a Coriolis Storm… Spoiler warning - this story is set between the first and second Dune novels, so if you haven't read Dune or seen the film bear in mind you're going to encounter some HEAVY spoilers. This is also the SECOND EPISODE so make sure you listen to Act I first! If you enjoyed this and are interested in more Dune content, check out Gom Jabbar wherever you listen to podcasts! Music by Noah Perito & Lisa Condemi Sound Effects: "wind-blowing-and-howling-in-a-barbed-fence-on-the-ground-desert-chile" - felixblume “Gut-a-blastix” - rolandseer “Battle with Monsters and Magic” - Michaël Ghelfi All sound effects from ⁠Freesound.org⁠, unless otherwise linked. Additional sound effects by Noah Perito.

They say everyone gets their day in court. For Big Tech, it's looking more like a reckoning. Kait from the Refresh reports on this weeks news. This Week's Breakdown: Meta on trial — Zuck, Sandberg, and Mosseri take the stand as the FTC argues Meta bought Instagram to “neutralize” a competitor. Old emails. Big receipts. Google found guilty — A federal judge rules Google's ad tech stack (DFP + AdX) violated antitrust laws. Remedy phase is next… and yes, Chrome's on the table. The stakes? Massive. Think forced divestitures, self-preferencing bans, and a playbook rewrite for AdTech. History rhymes — This is the biggest antitrust heat since Microsoft in '98. But the market's bigger, the stakes are higher, and the FTC isn't backing down. Future watch — If Google and Meta are Act I, who's Act II? OpenAI? Apple? The next decade's already heating up. Kait's closing note? “Get a good lawyer.” (T. Swift said it best.) Learn more about your ad choices. Visit megaphone.fm/adchoices

In Shakespeare's play, Antony and Cleopatra, Cleopatra declares “It is my birth-day: I had thought to have held it poor: but, since my lord Is Antony again, I will be Cleopatra.” Indicating that she was relieved to be marking the occasion in a better way. Julius Ceasar, similarly declares in Act V, “This is my birth-day; as this very day was Cassius born.” In Pericles, the First Fisherman says “he hath a fair daughter, and to-morrow is her birth-day;” (Act II).  In Shakespeare's Hamlet, Marcellus talks about celebrating our Savior's birth with singing. Other references to the day of one's birth show up in Henry VI Part II the Earl of Suffolk talks about having a cunning old man calculate the day of his birth (Act IV), and later in that same act, Jack Cade talks about how his father was ignorant of both his birth and parentage. All of these mentions of birth days, their calculations, and their celebrations, has me wondering what exactly birthdays were like for Shakespeare's England. We always celebrate Shakespeare's birthday in style in around here, but would the bard have celebrated his own day of birth? To find out, we've invited one of the authors of the article “Debating the Birthday: Innovation and Resistance in Celebrating Children” Peter Stearns, to the show to day, to help us explore the history of marking a birthday with cakes, gifts, and a gathering of friends. Would this have occurred for Shakespeare's lifetime? Let's find out right now, on That Shakespeare Life.   Get bonus episodes on Patreon Hosted on Acast. See acast.com/privacy for more information.

This week, Donald Macleod charts the highs and lows of the composer's last five years, from veneration to humiliation and back again. We hear how Mozart coped with all that life threw at him and somehow managed to compose many of the works he's most loved for today.Music featured:Requiem Ein musikalischer Spass (4th mvt, Presto) Symphony No 38 “Prague” (3rd mvt, Presto) Canon: Ach zu kurz ist unsers Lebenslauf String Quintet in G minor, K515 (2nd mvt. Adagio, arr. for piano) Serenade in G, K525 "Eine Kleine Nachtmusik" (1st and 2nd mvts) Don Giovanni, Act I, Madamina (Catalogue aria) Contredance in C major “La Bataille” Symphony No 40 (3rd mvt, Menuetto) Divertimento in E flat major, K 563 (1st mvt, Allegro) Piano Sonata No 16 in C major, K545 “Facile” (2nd mvt, Andante) Symphony No 41 “Jupiter” (1st and 2nd mvts) Kleine Gigue in G minor, K574 Vado, ma dove? Oh dei! K583 Piano Concerto No 26 "Coronation" (2nd mvt) Cosi fan tutte, Act 1, Un' aura amorosa “Prussian” String Quartet No 1 in D, K575 (2nd mvt) Clarinet Quintet in A, K581 (1st and 2nd mvts) Cosi fan tutte Overture Cosi fan tutte, Act II, Una donna Adagio and Allegro in F minor (originally for organ), K594 String Quintet in D, K593 (1st and 2nd mvts) La clemenza di Tito (Marcia) The Magic Flute Overture Piano Concerto in B flat, K595 (2nd mvt, Largo) Ave verum corpus, K618 Adagio for Glass Harmonica, K617a The Magic Flute, Act II, Scene 5, Ein Mädchen oder Weibchen Clarinet Concerto in A, K622 (1st mvt)Presented by Donald Macleod Produced by Amelia Parker for BBC Audio Wales & WestFor full track listings, including artist and recording details, and to listen to the pieces featured in full (for 30 days after broadcast) head to the series page for Mozart's Last Years https://www.bbc.co.uk/programmes/m0029psw And you can delve into the A-Z of all the composers we've featured on Composer of the Week here: http://www.bbc.co.uk/programmes/articles/3cjHdZlXwL7W41XGB77X3S0/composers-a-to-z

Cyndi Lauper is a multi-award winning singer and songwriter. She has sold more than fifty million records, won an Emmy for acting and her musical Kinky Boots earned her a Tony and an Oliver award. Born in 1953, Cyndi grew up in a blue collar neighbourhood in New York. Her mother loved music and art and took her children to free exhibitions in New York which inspired Cyndi. As a very young girl, Cyndi listened to her mother's extensive record collection and mimicked the voices she heard from musicals and operas.After a difficult family home life due to her mother's turbulent marriages, Cyndi found solace in music and began writing songs when she was ten. She left home at seventeen determined to make it in the music industry. She started out as a singer in bands, whilst supporting herself doing a series of jobs. Early in her career, she lost her voice for almost a year after trying to make herself heard over amps which were too loud. Success eventually came when she released her debut solo album She's So Unusual in 1983 – the first album by a female artist to spawn four consecutive US Top 5 singles.Cyndi lives in New York with her husband, David who is an actor. They met on a set of a film and rock legend Little Richard officiated their wedding.DISC ONE: Prelude to the Afternoon of a Faun. Composed by Claude Debussy and performed by The Orchestre National de Lyon DISC TWO: All That Meat and No Potatoes - Louis Armstrong And His All-Stars DISC THREE: Puccini, “Un bel di, vedremo” (“One fine day, we shall see”) from Act II of Madame Butterfly. Performed by Maria Callas with Orchestra del Teatro alla Scala di Milano, conducted by Herbert von Karajan DISC FOUR: Getting to Know You - Marni Nixon DISC FIVE: I Want Hold Your Hand - The Beatles DISC SIX: A Sailboat in the Moonlight - Billie Holiday And Her Orchestra DISC SEVEN: One Way or Another - Blondie DISC EIGHT: Hound Dog - Big Mama ThorntonBOOK CHOICE: Me Talk Pretty One Day by David Sedaris LUXURY ITEM: A luxury hotel CASTAWAY'S FAVOURITE: Puccini, “Un bel di, vedremo” (“One fine day, we shall see”) from Act II of Madame Butterfly. Performed by Maria Callas with Orchestra del Teatro alla Scala di Milano, conducted by Herbert von KarajanPresenter: Lauren Laverne Producer: Sarah Taylor

Bromance: How Dumb & Dumber and When Harry Met Sally are the Same Screenplay (21:42)   Up to 48% off your first subscription or 20% off one time purchases with code VALERIE20 at checkout You can claim it at: https://magicmind.com/VALERIE20 #magicmind #mentalwealth #mentalperformance PATREON: Thank you to our existing patrons for believing in our work offline and here in the podcast.  Become a patron of the arts at Patreon.com/valerieihsan for books, writing instruction, coaching, and planning. Go to Patreon.com/strangeairstories for short stories in the paranormal mystery genre.   Segment 1 (Announcements/Author Updates): Unlocking the Hearth of Your Memoir (Wordcrafters) Aligned Author: A Workshop in Intuitive Planning and Strategy (last weekend on Anderson Island)   (Erick) Spring Break, busy, marketing, When can I slot in phone calls?, less writing What are you reading? Valerie:  In the Dream House (Carmen Maria Machado) The Girl from the Grand Hotel (Camille Aubray) (Not ready to give up on them, but struggling to finish them:) Four Thousand Weeks: Time Management for Mortals by Oliver Burkeman; The Year of the Puppy (Alexandra Horowitz) ;  The Teller of Small Fortunes Julie Leong    Erick:   Stephen Brust's The Book of Jhereg (Vlad Taltos) Segment 2 (Resources/Tips/Tidbits): Tidbit #1: simplyscripts.com to read screenplays (not the bound screenplays in bookstores); Drew's Script-o-Rama; Scott Myers' Go Into the Story (Read scripts you've watched before and ones you haven't.) Tidbit #2:  Segment 3 (Mindset-Craft-Biz Check):    Segment 4 (Main Topic):   Romcom 90-100 pages Same beats in every story (might take longer to reach the beat.) Buddy comedies and romantic comedies reach beats at the same time. 1) Characters always odd couple. (Internal push/pull.) Emotional bonding early on. D&Dumber (Harry and Lloyd) WHMS (Harry and Sally) 2) Meet Cute (sparks the long term relationship/Will they survive as friends? Will they/Won't they tension at beginning of the movie--by page 5 (within 5-8 minutes) when the theme of the story is stated.  3) Page 12 is where story diverges and real problem starts. 12-25 emotional bonding is depicted. Quirky side characters introduced (opposite of main characters). 4) Page 25 is start of Act II. (25-30 central theme is tested. Page 30-55 Fun and Games, tested in fun ways (with minimal risk) 5) Midpoint (something happens and fun and games has more risk, stakes are different). Now antics are pointed towards each other. (Pages 55-70) 6) Page 75 (the dark night of the soul sequence starts here) characters hit rock bottom, how do the characters deal with it. 7) Ending (emotional payoff and repair what's broken).      And don't forget: Get 48% off the Magic Mind : https://magicmind.com/VALERIE20 and use Valerie20 at checkout. #magicmind #mentalwealth #mentalperformance   Next episode: Guest H.H. Rune on Letting Your Story Go Out into the World.

Every disciple of the straight and narrow way that leads to life (Matthew 7:13-14) must inevitably experience the afflictive consequences of their former actions. The question becomes if they do so with resignation, acceptance, and perseverance, so that by consciously and patiently paying what one owes before the divine law, spiritual debts are reconciled and wisdom is cultivated. However, the process is a prolonged and grueling one, designated by some authors as “dark nights of the soul.” In such moments of despair, loneliness, and abandonment, the practitioner lacks inner illumination to guide them forward in the psychological work, or as Christ exclaimed on the cross: “My God, My God, why hast Thou forsaken Me?” (Matthew 27:46). While spiritual nights are painful and experienced by everyone in the Gnostic path, they are a necessary step towards self-realization, for ordeals and tests are fundamental for proving one's candidacy in the mysteries. As Beethoven demonstrated in his life and his only opera, the initiate can overcome the punishment of the law through tenacity, negotiation, forgiveness, and supreme faith in divinity. See how in the conclusion of Beethoven's only opera, whereby Florestan seeks his liberation from the prison of karma with the help of his courageous wife Leonora, the divine soul that descends like an angel from heaven to redeem the fallen Sophia.

This week is fully stacked! Join  ⁨@tiddly⁩   ⁨@Eseipha⁩   ⁨@samikat⁩   ⁨@EpicDan⁩  &  ⁨@danfinitygg⁩  as they talk about the Heresy Act II Reveal, Guardian Games return, Rushdown, Ultimatum and so MUCH MORE!Listen to Destiny Digests:Spotify: https://open.spotify.com/show/51utOpaycri2x7WotgVlFXApple: https://podcasts.apple.com/us/podcast/destiny-digest/id1638939545On Bluesky? Follow our Guest Starter Pack: https://bsky.app/starter-pack/danfinity.gg/3lbrtal4y7c2rFollow Bona: https://bsky.app/profile/bonafidehiro.bsky.socialFollow Danfinity: https://danfinity.ggFollow EpicDan: https://linktr.ee/epicdan22Follow Eseipha: https://bsky.app/profile/eseipha.bsky.socialFollow Sami: https://linktr.ee/samikatplaysFollow Tiddly: https://bsky.app/profile/tiddly.bsky.social

Join us this week for our massive breakdown of all the latest Bungie livestream info, going over the new activity; Court of Blades and the rest of the Act 2 & 3 details for Episode Heresy. We detail all the latest changes with the upcoming Guardian Games event coming this Tuesday at reset, including the new boss-rush mode Rushdown. We chat about the welcome improvements to the Trials of Osiris and Comp game modes. Respawn gets all emotional about the Sundered Doctrine Dungeon weapons and Monster Hunter for the 5 minutes we let him. Plus we have a few tips and tricks to help.   00:00:00 – Opening & Monster Hunter Chat 00:03:56 - More Monster Hunter Ramblings 00:04:49 - Introductions 00:06:03 - Moments of Triumph 2024 00:08:10 - Vault Space 00:17:51 - Trials of Osiris & Redrix's Estoc 00:31:08 - 14th Dregen Title Reset & Sundered Shenanigans 00:43:48 - Barrow-Dyad & Other Exotic Submachine Guns 00:50:24 - Moments Again 00:52:54 - Exo Body, Yes Please 00:54:03 - Heresy Act 2 Livestream Breakdown 01:01:02 - Dungeon Weapon Diversion 01:08:12 - Heresy Act 2 Weapon Breakdown 01:29:38 - Artifact Update & This Week at Bungie: March 6th 2025 01:29:38 - Heresy Act 3 Preview 01:40:53 - Rite Of The Nine Information 01:44:45 - Rite Of The Nine Weapons 01:52:57 - Guardian Games 2025 Information 01:55:25 - Guardian Games Weighting Issues In The Past 01:59:17 - Rushdown - New Boss Rush Mode 02:00:58 - Guardian Games Weapons 02:01:58 - Guardian Games Warning 02:03:17 - Guardian Games Glows 02:08:12 - Guardian Games Eververse 02:10:24 - Guardian Games Skimmer 02:12:05 - Guardian Games Cards & Rewards 02:15:09 - Guardian Games Rushdown Roulette 02:18:33 - Heresy Act 2 Crucible Update 02:28:06 - Trials This Week & Account Update 02:31:15 - Bungie Store Sale 02:32:30 - More Fashion Feedback 02:33:21 - Daylight Savings 02:34:18 - Account Recovery & Cheating 02:35:55 - Peroty's Player Support 02:43:34 - End Of The TWAB 02:44:38 - This Week In Destiny: Heresy Act 2 - Week 6 02:55:56 - Respawn Report Round-Up 02:59:49 - Tips, Tricks & Guides & Builds 03:08:16 - Patreon Thanks & End of the Show 03:11:47 - End Two Titans and a Hunter YouTube Channel Two Titans and a Hunter Twitch Two Titans and a Hunter Discord Two Titans and a Hunter - Patreon Two Titans and a Hunter Ko-Fi The100 io – GH/GD/2TAAH Group Email: twotitansandahunter@hotmail.com Two Titans and a Hunter Twitter Two Titans and a Hunter – Facebook Artwork by @Nitedemon Xbox Live: Nitedemon, Peroty, Not Arf & No1RespawnsInRL End credits theme song by Elsewhere - YouTube Channel Plus as always, thank you to Alexander at Orange Free Sounds & www.freesound.org for all the sound effects used in our podcast.  Required Stuff: Bungie - This Week at Bungie March 6th 2025 360GameTV - Old Season Pass Access Daltnix - 0.43 TTK Hunter PvP Build Spade - The Most Terrifying Prismatic PvP Hunter Build Aztecross - Unkillable Titan PvE Build Esoterickk - Solo GM Titan Sword Build Duddits II - Crazy Kinetic Tremors/Elemental Honing Mactics - Best Meta Titan PvE Build Jackeddidge - 27 Free Raid Chest For Solo's Maven - It's Better Than You Think: Titan Build Esoterickk - YouTube Channel Twitch - GuardianDownBot Raid Checkpoints Twitch - IceBreakerCatty. Pluderthabooty Channel Mactics Channel Engram.Blue Link

Linktree: ⁠https://linktr.ee/Analytic⁠ In this segment of Notorious Mass Effect, Analytic Dreamz reacts to the DAWN BREAKS // Waylay Agent Trailer - VALORANT. Exploring the reveal of Waylay, VALORANT's new Thai Duelist, Analytic Dreamz dissects her light-bending abilities and dynamic gameplay. Launched with Season 25: Act II on March 5, 2025, Waylay's prismatic powers promise to shake up the meta. Analytic Dreamz offers in-depth analysis on her kit, from dashes to hindering effects, and what it means for players. Tune in for expert insights and reactions to this dazzling addition from Analytic Dreamz.Support this podcast at — https://redcircle.com/analytic-dreamz-notorious-mass-effect/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

This is second episode of the KRZ deep dive series and community playthrough. We cover Act II of the game — the Bureau of Reclaimed Spaces, The Zero, Random Access Self Storage, The Museum of Dwellings, and the Forest — and the second interlude, an interactive play entitled 'The Entertainment'.Thanks to everyone in the patron Discord who submitted comments and questions! Join them in supporting the show, and play along with us: http://patreon.com/gaminginthewild.Hop over and sub to the YouTube for more GITW stuff, including the Next Fest roundup coming later this week: http://youtube.com/gaminginthewild.And thanks for listening!

In this episode, Michaela Ayers explores the transformative power of love, creativity, and community care. Reflecting on her journey through the Seeda School for Black feminist worldbuilding, Michaela shares how the recovery of her creative spirit has shaped her latest offering—The Art of Black Love, a collage and memory workshop. Join us inside Wa Na Wari, a historically Black home turned cultural space, where participants gather to reflect on love in all its forms. Listen as workshop attendees, including Rachel Chapman, bring their memories to life through creative writing and collage. Resources: Sign up for Michaela's Creative Moments newsletter to learn more about her offerings. To listen to Act II, join BHS on Substack. Discover the work of Rachel Chapman, Associate Professor of Cultural Anthropology. Learn more about Ayana Zaire Cotton and Seeda School, a liberatory space that explores Black feminist worldbuilding and creative actualization. Check out Wa Na Wari's work advancing belonging through Black arts and Culture in Seattle. 

President Trump's first month in office (Act II) has been a whirlwind of executive orders, controversial cabinet picks, and precedent-breaking calls to take over foreign countries. But since the most important issue to voters in 2024 was the economy, the team discusses why new polling suggests many Americans are questioning the administration's priorities.Then, another Trump action -- calling for all remaining records of the assassinations of JFK, RFK, and MLK be released -- got us thinking about how prevalent conspiracy theories are in America. So, we went back in the archives to see how Americans' beliefs in conspiracy theories have and haven't changed over the decades.Finally, Trump's call for the US to take Greenland from Denmark is NOT unprecedented. Indeed, it was an idea in post-war America that gained enough traction to have a poll question asked about it!

In this College Deep Dive, Lauren Haughton, BFA Director at FSU and MTCA Director Charlie Murphy Discuss: 

Curtain-up on the life of 19th-century opera star Giacomo Meyerbeer, with Donald MacleodWith smash hits including 'Robert le diable', 'Les Huguenots' and 'Le Prophète', Giacomo Meyerbeer was one of the most performed composers on the 19th-century stages: (re)discover the celebrated King of Grand Opera, in his own quasi-operatic life of sparkling successes, plot twists and travelling adventures, but also of prejudice and hardship.Music Featured:Robert le diable (excerpts) Le pardon de Ploërmel, Act I, "Ce tintement que l'on entend" L'Africaine, Act IV, No 15 Entr'acte, Entrée de la Reine, Marche indienne Der Fischer und das Milchmädchen (excerpts) Der Admiral Overture Gott und die Natur (No 7, "Es geht aus seinem Strahlentor") arr D. Salvi for voice, strings & piano Das Brandenburger Tor (Einleitung) Jephtas Gelübde Overture (arr D. Salvi for piano and strings) Il nascere e il fiorire d'una rosa Le Prophète, Act I (No 1a: Prélude et chœur pastoral. "La brise est muette") Gli amori di Teolinda (IV. Allegro moderato) Romilda e Costanza Overture Emma di Resburgo, Act I, Scene 1: "Sulla rupe triste, sola...Ah questo bacio" Il crociato in Egitto (excerpts) Margherita d'Anjou, Act II, "Che bell'alba!" A une jeune mère An Mozart Struensee, Act II: Entr'acte, Der Ball Les Huguenots (excerpts) Fantasie for clarinet & string quartet Ein Feldlager in Schlesien (excerpts) Psalm 91 Le Prophète (excerpts) Pater Noster L'Étoile du Nord, Act III, Scène 8. "Quel trouble affreux" (Danilowitz)Presented by Donald Macleod Produced by Julien Rosa for BBC Audio Wales & WestFor full track listings, including artist and recording details, and to listen to the pieces featured in full (for 30 days after broadcast) head to the series page for Giacomo Meyerbeer (1791-1864) https://www.bbc.co.uk/programmes/m0027bqw And you can delve into the A-Z of all the composers we've featured on Composer of the Week here: http://www.bbc.co.uk/programmes/articles/3cjHdZlXwL7W41XGB77X3S0/composers-a-to-z

Let's talk about the Heist arc (or the Jailbreak arc? No, the Heist arc!) with Ben and Phil. And stay tuned at the end for a very important announcement! And a sneak preview!

- More attempts at ASMR from Ryan - When Airplanes Get Hungry - The worst place to watch Act II of Oklahoma - The Mystery of the Abandoned Retirement Community Car - Katie vs. Biker Gang vs. Cops vs. Katie - Sewage Pump Missile Keys - May God grant you the confidence of a lady who brings her bird wherever she pleases - Forklifts: The Ultimate Revenge Tool - Bring Him Home (him is a gun)- This week's theme song arranged and performed by Michael Surber with Metallica- Listen to Ryan's other, less harrowing show, We're Not All Like This, and check out his narrative podcast with Steven Godfrey, Who Killed College Football? https://www.wkcfb.com - Check out Jason's free newsletter and other work: https://www.jasonkirk.fyi/ - Find Holly and Spencer writing and chirping at https://channel-6.ghost.io/ - Purchase only the finest Fullcast gear at sunny https://preownedairboats.com/

In this College Deep Dive Robert Hoyt the Director of Admissions & Recruitment for NYU Tisch Drama and MTCA Director Charlie Murphy chat about: Early decisions submission strategy  Fill out your FAFSA, even if you do not like you will qualify  Authenticity versus strategy  Multi-hyphenates NYU cultivates  Visit @thefund4collegeaudition to learn about the Fund and relief efforts.  If you have any questions about the college audition process, feel free to reach out at mailbag@mappingthecollegeaudition.com. If you're interested in working with MTCA for help with your individualized preparation for your College Audition journey, please check us out at mtcollegeauditions.com, or on Instagram or Facebook.  Follow Us!  Instagram: @mappingthecollegeaudition YouTube: @MTCA (Musical Theater College Auditions)  TikTok: @mtcollegeauditions  Charlie Murphy:@charmur7  About MTCA:  Musical Theater College Auditions (MTCA) is the leader in coaching acting and musical theater students through the college audition process and beyond with superlative results. MTCA has assembled a roster of expert artist-educators who can guide students artistically, organizationally, strategically, and psychologically through the competitive college audition process. MTCA provides the tools, resources, and expertise along with a vast and strong support system. They train the unique individual, empowering the artist to bring their true, authentic self to their work. MTCA believes that by helping students reveal their potential it allows each school to connect with those who are truly right for their programs, which in turn guides each student toward their best college fit.  About Charlie Murphy:  Charlie is a proud graduate of Carnegie Mellon University's BFA program. As an Actor he has performed with theaters such as: NY Public Theatre's “Shakespeare in the Park”, The Pearl Theatre Company, Hudson Valley Shakespeare Festival, Chautauqua Theatre Company, Kinetic Theatre Company, and the Shakespeare Theatre of DC. With MTCA [Musical Theater College Auditions -- mtca.nyc], he has been helping prospective theatre students through the college process for over 15 years. As a Teacher and Director, he is able to do a few of his favorite things in life: help students to find their authentic selves as artists, and then help them find their best fit for their collegiate journey. Through this podcast, he hopes to continue that work as well as help demystify this intricate process. This episode was produced by Kelly Prendergast. Episode theme music is created by Will Reynolds with Additional Vocals from Elizabeth Stanley Learn more about your ad choices. Visit megaphone.fm/adchoices

The Holidays are a time for watching movies, and we need an entire episode to catch you all up on what we've caught up on… including The Brutalist, Babygirl, A Real Pain & over 40 movies. These reviews are mostly Spoiler Free. HOWEVER, we do discuss some mid-Act II events for a few movies like The Brutalist, Y2K and Juror No. 2. NEW FILMS REVIEWED: The Brutalist - 1:26 Oscars & Globes Betting Odds Updated For The Brutalist, etc - 14:36 All We Imagine As Light then reviewing (September 5) Nowon East Village - 24:05 Babygirl - 28:47 The Lord of the Rings: The War of the Rohirrim, La Cocina & Y2K - 34:40 The People's Joker - 39:15 A Real Pain - 41:32 Bird - 45:18 The Six Triple Eight - 47:14 Small Things Like These - 49:21 Out Of My Mind- 51:13 Juror No. 2 - 54:17 Red One, Sweethearts, Late Bloomers, Coup!, Lonely Planet - 59:03 Rewatches of Will & Harper, My Old Ass, Conclave, etc - 1:03:11 OLDER FILMS: Family Movie Nights: Hombre, The Shootist, The Crimson Pirate - 1:05:46 Christmas Movies: The Feast of the Seven Fishes, It's A Wonderful Life, A Christmas Vacation, A Christmas Story, The Holdovers - 1:07:12 Mike's Tour of the film year of 1967 continues: In The Heat of the Night & Guess Who's Coming For Dinner, The Graduate, In Cold Blood, Bonnie & Clyde, Cool Hand Luke, Wait Until Dark, The Producers, The Dirty Dozen, Point Blank - 1:08:08 OUTRO: Let us know your thoughts (especially with all the opinions we have to lay down in this episode). Plus, what's coming next might involve some radio time and words of wisdom.

Watch The Muppet Christmas Carol with commentary from Mike Flanagan and Brian Henson. Stream it on Disney+ , Amazon or anywhere you can find it. Go physical media! This signal has been transmitted by SpectreVision Radio Featuring Brian Henson Hosted by Mike Flanagan | @flanaganfilm Edited by Graham Reznick | @grahamreznick Learn more about your ad choices. Visit megaphone.fm/adchoices

Pastor Omar delved deeper into the book of Jasher, offering profound insights into the extraordinary story of Abraham and Isaac. We explored the untold details of Satan's challenge to God, where he questioned Abraham's faithfulness, accusing him of only serving God because of His blessings. Pastor Omar unpacked Satan's bold claim that humanity often turns away from God after receiving their blessings, only returning when faced with trouble. In this powerful message, we learned how the kingdom of darkness operates with a frightening level of organization, discipline, and strategic focus. Pastor Omar contrasted this with the tendency of the church to sometimes lack unity, struggle with following leadership, or get distracted by internal conflicts. The message was a call to action for believers: we must stand together, aligned in purpose, and fully committed to spreading the Gospel of Jesus Christ. Above all, Pastor Omar reminded us of the importance of gratitude—never forgetting the goodness of God in our lives, especially during times of blessing. Let this message inspire us to reflect, unify, and press forward in our faith journey.

Dr. Van Morris presents the new evidence-based guideline on systemic therapy for localized anal squamous cell carcinoma. Dr. Morris discusses the key recommendations from the Expert Panel, including recommended radiosensitizing chemotherapy agents, dosing and schedule recommendations, the role of induction chemotherapy and ongoing adjuvant chemotherapy, and considerations for special populations. He emphasizes the importance of this first guideline from ASCO on anal squamous cell carcinoma for both clinicians and patients with stage I-III anal cancer, and ongoing research the panel is looking to for the future. Read the full guideline, “Systemic Therapy for Stage I-III Anal Squamous Cell Carcinoma: ASCO Guideline” at www.asco.org/gastrointestinal-cancer-guidelines. TRANSCRIPT This guideline, clinical tools, and resources are available at http://www.asco.org/gastrointestinal-cancer-guidelines. Read the full text of the guideline and review authors' disclosures of potential conflicts of interest in the Journal of Clinical Oncology, https://ascopubs.org/doi/10.1200/JCO-24-02120 Brittany Harvey: Hello and welcome to the ASCO Guidelines podcast, one of ASCO's podcasts, delivering timely information to keep you up to date on the latest changes, challenges and advances in oncology. You can find all the shows, including this one at asco.org/podcasts. My name is Brittany Harvey and today I'm interviewing Dr. Van Morris from MD Anderson Cancer Center, co-chair on “Systemic Therapy for Stage I-III Anal Squamous Cell Carcinoma: ASCO Guideline.” Thank you for being here today, Dr. Morris. Dr. Van Morris: Thank you for having me. On behalf of our committee who put together the guidelines, I'm really excited to be here and talk with you today. Brittany Harvey: Great. Then, before we discuss this guideline, I'd like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO Conflict of Interest Policy is followed for each guideline. The disclosures of potential conflicts of interest for the guideline panel, including Dr. Morris, who has joined us here today, are available online with the publication of the guideline in the Journal of Clinical Oncology, which is linked in the show notes. So then, to jump into the content of this guideline, Dr. Morris, can you provide an overview of both the purpose and the scope of this guideline on stage I to III anal squamous cell carcinoma? Dr. Van Morris: So anal cancer is considered a rare malignancy for patients in the United States and across the world as well. Even though it's not something we see as commonly, for example, as the adjacent colorectal cancer, this still is a cancer that is rising in incidence every year in the United States. And really, despite the presence of the preventative HPV vaccines, which we hope will ultimately prevent and eradicate this cancer, we still expect the incidence to continue to rise in the coming decades before we really start seeing numbers begin to decrease as a result of the vaccine. So this is an alarming trend for which oncologists will continue to see likely more and more cases and new diagnoses every year. So we wanted to review the most recent literature and provide oncologists up to date recommendations for how they can best take care of patients with a new diagnosis of localized anal cancer. Brittany Harvey: Absolutely. I appreciate that background and context to set the stage for this guideline. So then next I'd like to review the key recommendations of this guideline. So starting from the first clinical question, what are the recommended radiosensitizing, doublet or single chemotherapy agents for patients with stage I to III anal cancer? Dr. Van Morris: It's true that really the standard treatment for patients with localized anal cancer has not changed over the last literally half century. When the Nigro regimen was first reported back in 1974, 50 years ago, the standard of care for patients with a new diagnosis of localized anal cancer centers around concurrent chemotherapy and radiotherapy. And we looked at the various randomized control trials and the highest level of evidence which has been reported over the past decades, and really for most patients, the standard of care continues to remain doublet cytotoxic chemotherapy in combination with radiation. We reported that the most commonly, and I think most accepted, regimen here is a combination regimen of 5-FU, intravenous 5-fluorouracil with mitomycin C. And this most commonly is given on a week 1 to 5 regimen. The 5-FU, we recommended a dose of 1000 milligrams per meter squared per day on days 1 to 4 and then on days 29 to 32 of the radiation treatment. And then the mitomycin C, looking at various trials, has been given at a dose of 10 milligrams per meter squared on day 1 and day 29, or alternatively a single dose of mitomycin C at 12 milligrams per meter squared on day 1. I think that the thing that's important for clinicians and patients alike to remember is that this chemotherapy can be very toxic in patients who are undergoing a curative-intent therapy for this diagnosis of localized anal cancer. I think it's just important for oncologists to be watching closely the blood counts for the patients to make sure that the myelosuppression doesn't get too bad. And then in select cases, if that is the case, when the oncologist opts to go for the day 1 and day 29 dosing, it may be prudent, if the myelosuppression is too excessive, to consider withholding that day 29 dose. Brittany Harvey: Great. Thank you for providing those recommendations along with some of those dosing and the schedule recommendations from the expert panel. So are there any other alternate dose or schedule recommendations from the expert panel? Dr. Van Morris: Yeah, but I think that we saw with the ACT II data that was a randomized trial that was done out of the UK that compared 5-FU mitomycin with 5-FU cisplatin as two different doublet cytotoxic regimens, that overall outcomes were very similar between the two regimens in terms of curative outcomes for patients treated whether 5-FU mitomycin or 5-FU cisplatin. So certainly there is evidence supporting the use of cisplatin as a second cytotoxic agent with 5-fluorouracil. In the ACT II study that was given at a dose of 60 milligrams per meter squared on days 1 and 29 along with the 5-FU at the regimen I talked about previously. There is other lower level of evidence data suggesting that even the 5-FU and cisplatin can be given on a weekly schedule and that that can be safe. Actually, at my institution at MD Anderson, that is our standard practice pattern as well. There's also the option when we're thinking about giving pelvic radiation for patients with lower GI cancers, many oncologists in the treatment of localized rectal adenocarcinoma are accustomed to using capecitabine as a chemosensitizer in patients with localized rectal cancer. If I'm giving chemoradiation for a patient with localized anal cancer, can I substitute the intravenous 5-FU with oral capecitabine? And although the evidence is not as strong in terms of available data with regards to randomized controlled trials, there certainly is data that suggests that capecitabine may be an acceptable alternative in lieu of intravenous 5-fluorouracil that would be given at a dose of 825 milligrams per meter squared on days of radiation. But certainly, I think that that's a feasible approach as well and maybe even associated with less hematologic toxicity than intravenous 5-FU would be. Brittany Harvey: Great. It's important to understand all the options that are out there for patients with early-stage anal squamous cell carcinoma. So in addition to those chemoradiation recommendations, what is recommended from the expert panel regarding induction chemotherapy or ongoing adjuvant chemotherapy for this patient population? Dr. Van Morris: When we think about treating patients with lower GI cancers with curative intent therapies, when we think about the more common rectal adenocarcinoma, oncologists may be used to giving chemoradiation followed by subsequent cytotoxic chemotherapy. But actually when you look at the data for anal cancer, really there's not any data that strongly supports the use of either induction chemotherapy prior to chemoradiation or adjuvant post-chemoradiation chemotherapy. The RTOG 98-11 study was a trial which evaluated the role of induction 5-fluorouracil prior to chemoradiation and did not show any survival benefit or improved outcomes with the use of induction chemotherapy in a randomized control trial setting. The ACT II trial, which I referenced earlier, was a 2 x 2 design where patients were either randomized to concurrent chemoradiation with 5-FU mitomycin C or concurrent chemoradiation with 5-FU cisplatin. But then there was a second randomization after chemoradiation where half of the study participants received adjuvant cisplatin 5-fluorouracil after completion of their chemo radiation, or the other half were randomized to the standard of care, which of course would be observation. And what that trial showed was that there was no added benefit with the addition of post-chemoradiation cytotoxic chemotherapy. So we look at these data and say that in general, for the general population of patients with localized stages I to III anal cancer, there really is no supporting data suggesting benefit of either induction chemotherapy or adjuvant chemotherapy. And to that end, really it's concurrent chemoradiation remains the standard of care at this time for patients with a new diagnosis of localized anal cancer. Brittany Harvey: Absolutely. It's just as important to know what is not recommended as it is to know what is recommended for these patients. And so I thank you for explaining the evidence behind that decision from the panel as well. So then, are there any other considerations for special populations that oncologists should consider? Dr. Van Morris: I think so. I think that anal cancer is a disease where we don't see that many patients being diagnosed earlier at a younger age, especially in relation to the alarming trend of early onset colorectal cancer that we're currently seeing right now. So there may be patients who come with a new diagnosis of localized anal cancer who are an octogenarian at an advanced age or may have other significant medical comorbidities. And if that is the case, we get called about this quite frequently from outside institutions. I have an 85 year old who is coming to my clinic with this diagnosis. I don't feel comfortable giving this patient doublet cytotoxics, what options do I have? Especially given other organ dysfunction that may precede this diagnosis. And I think that in that case, there are times when it's okay safely to drop the mitomycin C and opt for single agent 5-fluorouracil as a single cytotoxic agent. So I think that that would be something that we've certainly incorporated into our practice at our institution. There's also an association between various autoimmune disorders, patients on immunosuppression, even persons living with HIV being at higher risk for this virally associated cancer. So I think that, again, if the patient is coming with baseline immunosuppression for these reasons prior to treatment, certainly kind of being in tune to the potential for hematologic toxicity. And watching these patients very closely as they're getting chemoradiation remains really important. Brittany Harvey: Definitely. So, you've just discussed some of those comorbidities and patient characteristics that are important for clinicians to consider when deciding which regimens to offer. So in addition to those, in your view, what is the importance of this guideline and how will it impact clinical practice for clinicians who are reading this guideline. Dr. Van Morris: Chemoradiation remains a very effective option and most patients will be cured with this diagnosis and with this treatment. So it's important to make sure that these patients are able to safely get through their treatment, minimizing treatment delays due to toxicities which may come about because of the treatment, and really help to carry them over the finish line so that they have the best likelihood for achieving cure. So we really hope that these data will provide oncologists with a readily available summary of the existing data that they can refer to and continue to help as many patients as possible achieve and experience a cure. Brittany Harvey: Absolutely. So then to build on that, it's great to have this first guideline from ASCO on anal squamous cell carcinoma. But how will these new recommendations affect patients with stage I to III anal cancer? Dr. Van Morris: I certainly hope it will allow patients and oncologists to know what their options are. It certainly is not a one size fits all treatment approach with regards to the options which are available. Depending on the patient, depending on the various medical conditions that may accompany them, these treatments may need to be tailored to most safely get them through their treatment. Brittany Harvey: I appreciate you describing the importance of this guideline for both clinicians and patients. So what other outstanding questions and future research do you anticipate seeing in this field? Dr. Van Morris: It's a really good question and I think that there is a lot coming on the horizon. Even though the standard treatment has really not changed over the last half century, I think it still remains true that not all patients will achieve cure with a chemoradiation treatment. So a recent trial has completed enrollment in the United States, this is the EA2165 trial led by one of our committee members, Dr. Rajdev and Dr. Eng as well, that's looking at the use of nivolumab anti PD-1 immunotherapy after completion of concurrent chemo adiation. So in that trial, patients were randomized to concurrent chemoradiation followed by either observation or six months of adjuvant anti PD-1 therapy. We're really awaiting the results of that. Hopefully if we see an improvement with the addition of nivolumab following concurrent chemoradiation, our hope would be that more patients would be able to achieve a cure. So we're certainly looking forward to the outcomes of that EA2165 study. And then I think one question that we often get from our patients in the clinics is, “What is the role of circulating tumor DNA in the management of my disease?” And really, to date there have been some series which have shown that we can assess patients or circulating tumor DNA after completion of their concurrent chemo radiation that may need to start about three months after to give time for the radiation to wear off and most accurately prognosticate that. But I think that this will be a powerful tool moving forward, hopefully, not only in the surveillance to identify patients who may be at high risk for recurrence, but ultimately to translate that into next generation clinical trials which would treat patients at higher risk for recurrence by virtue of a detectable circulating tumor DNA result. In doing so, hopefully cure even more patients with this diagnosis. Brittany Harvey: Yes, we'll look forward to these developments and hope to add more options for potential treatment and surveillance for patients with anal cancer. So, I want to thank you so much for your work to develop these guidelines and share these recommendations with us and everything that the expert panel did to put this guideline together. Thank you for your time today, Dr. Morris. Dr. Van Morris: Thank you. And thank you to ASCO for helping to keep this information out there and ready for oncologists for this rare cancer. Brittany Harvey: Absolutely. And finally, thank you to all of our listeners for tuning in to the ASCO Guidelines podcast. To read the full guideline, go to www.asco.org/gastrointestinal-cancer-guidelines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines app, which is available in the Apple App Store or the Google Play Store. If you have enjoyed what you've heard today, please rate and review the podcast and be sure to subscribe so you never miss an episode.   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity or therapy should not be construed as an ASCO endorsement.    

Today, Pastor Kyle takes a close look at the various people (aka “characters”) in the Christmas story in light of the culture at that time. This aspect of the Christmas story shows us that God keeps His promises. Part 2 (Act II) continues next week. There is also a video (the audio track only), within Pastor Kyle's message, that portrays Zechariah and his wife Elizabeth. Only Elizabeth is talking in the audio, Zechariah is writing (refer to Luke chapter 1).

Joel, and Stephen discuss Act II, and Act III, the final episodes of Arcane. Joel has been playing around in the FICS*MAS holiday event in Satisfactory, and Stephen has some handy, productive apps to share.Show notes for The Citadel Cafe are here:http://www.thecitadelcafe.com/2024/12/10/the-citadel-cafe-487-arcane-season-2-finale/Join The Citadel Cafe Discord community!http://Patreon.com/TheCitadelCafeThe Citadel Cafe YouTube:https://youtube.com/thecitadelcafe Hosted on Acast. See acast.com/privacy for more information.

The panel discusses the the play's contrasts of public and private settings, its parallelism of scenes and characters (especially Calphurnia and Portia), and how Caesar's hubris, confidence, and superstition ultimately prove to bend the hinge of fate.Continue reading

Act II builds on the suspense and burgeoning relationship between Rodolfo and Mimi, newfound neighbors and bohemian lovers in the Latin quarter of Paris. Their spark of divine love is juxtaposed with the contrasting passion and suffering of Marcello and Musetta, the latter whose adulterous liaison serves as the locus of lustful competition, jealousy, and spite. Such destructive tendencies are representative of our collective humanity's consequent obsession with carnal desire and adultery, symbolized in Revelations as the scarlet whore who entices the multitudes with false prophecy and blind promises that lead to intense affliction. See how spiritual initiates like Puccini warned against following blind passion and the ways to recognize salvation within oneself: the path of chastity or sexual purity within the perfect matrimony.

What is This Feeling? I think its... the need to chit chat! Quick, we only have One Short Day to head to Dear Old Shiz and discuss the immensely Popular (and overwhelmingly amazing) WICKEEEEED! On the way we discuss our complicated relationships with musical theater, the almost absurd magnetism of Jonathan Bailey, and all that's to come in Act II next year. Subscribe to our PATREON for ad-free eps, video eps, weekly bonus eps, and more! Insta & TikTok: @filmbrospod

Way before Dorothy Gale landed in Oz, The Wicked Witch of the West wasn't wicked at all! The origin story to The Wizard of Oz is all laid out in this season's most spectacular book to stage to screen adaptation, Wicked. Nick and Sophia, along with special returning guests Connor and Dylan MacDowell from the DRAMA. podcast start by discussing their relationships with the stage musical and how that informed their first viewings of the new film.Then, they dive into their thoughts on the casting, including some favorites from the stage musicals, before highlighting Cynthia Erivo, Ariana Grande, and Jonathan Bailey, amongst many others (32:28). How do they feel about their singing live on set? They debate if comparisons to other series, remakes or two-parters, like Dune, Harry Potter or West Side Story, are valid. Then they get into some spoilers from the movie and Act II (what's to come in Part Two) later on along with sharing their favorite dance numbers (58:00). Of course they discuss the movie's Oscar potential and share which one Oscar they would award the film (1:14:04). They also answer some fun listener questions to help wrap up the episode! Let us know what you think of Wicked (Part One).Follow DRAMA. at @thedramapodcastFollow Connor MacDowell @ConnorMacDowellFollow Dylan MacDowell @dylanmacdowellFollow us on Twitter, Instagram, Bluesky, and TikTok @oscarwildpodFollow Nick @sauerkraut27Follow Sophia @sophia_cimMore content including updated nomination predictions @ oscarwild.squarespace.comMusic: “The Greatest Adventure” by Jonathan Adamich

Watch Pig with commentary from Mike Flanagan and Michael Sarnoski. Stream it on Hulu, Amazon, or anywhere you can find it. Go physical media! This signal has been transmitted by SpectreVision Radio Featuring Michael Sarnoski Hosted by Mike Flanagan | @flanaganfilm Edited by Graham Reznick | @grahamreznick You can now join Directors Commentary with Mike Flanagan on Patreon! https://www.patreon.com/directorscommentarypod Learn more about your ad choices. Visit megaphone.fm/adchoices

This week the crew is back for episode 406!00:00:01 Watts, Briar, Myelin and Fran Return00:02:31 Destiny 2: Tomb of Elders, Revenant Act 2 Story & More00:12:58 Bomb Cyclone Hits Northwest & Bungie HQ00:15:46 Stalker 2 Impressions with Briar00:31:40 The Game Awards Nominees & Elden Ring DLC00:59:00 Black Myth: Wukong So Far… Fran About 80% In1:09:34 Stellar Blade is Stellar Reminder from Watts1:11:00 Sony May Buy Kadokawa (Crunchyroll… From Software…)1:20:15 The Last Faith1:22:30 Pokemon Trading Card Game (TCG) Pocket1:30:15 Supervive1:35:42 Halo: Infinite - Returning with Myelin1:42:14 Questions from Social--------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel!https://www.twitch.tv/dcp_live/Our Patreon is now LIVE!https://www.patreon.com/dcp_liveJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel! https://www.twitch.tv/dcp_live/Our Patreon is now LIVE! https://www.patreon.com/dcp_liveJoin our DCP Discord Server! https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP" https://scufgaming.com/--------------------------------------------------------

In this episode of Decoding TV, David Chen and Patrick Klepek discuss everything that's happening in the world of TV, including Netflix's wildly popular fight between Jake Paul and Mike Tyson. Then, they dig into the season premiere of Dune: Prophecy and Act II of Arcane Season 2.What did we think of Netflix's big Paul vs. Tyson fight? Are we excited for Conan O'Brien to host the Oscars? Is Dune: Prophecy the type of prequel that fills in the details we care about? And is there any way Arcane season 2 can stick the landing? Listen to hear us discuss all these questions and more.Homework for next week:Silo Eps 1-2 (Apple TV+)Arcane Season 2 Act III (Netflix)Possible Bonus Ep: Interior Chinatown (Hulu)Shownotes:01:30 - Netflix Claims 108M Viewers Worldwide for Jake Paul-Mike Tyson Boxing Match20:30 - Conan O'Brien Will Host the Next Academy Awards23:40 - Comcast Plans Massive Cable Spin-Off, Separating USA, MSNBC and More From NBC, Theme Parks28:00 - ​​HBO Says ‘Harry Potter' Series Will ‘Benefit' From J.K. Rowling's Involvement: She ‘Has the Right to Express Her Personal Views'41:13 - Dune: ProphecyEp 1 - The Hidden Hand1:09:48 - Arcane Season 2 Act IILinks:Listen to Patrick's videogame podcast, Remap RadioSubscribe to Patrick's newsletter, CrossplaySubscribe to this podcast on YouTubeFollow this podcast on InstagramFollow this podcast on TiktokSubscribe to David's free newsletter, Decoding EverythingFollow David on InstagramFollow David on Tiktok Hosted on Acast. See acast.com/privacy for more information.

Watch The First Omen with commentary from Mike Flanagan and Arkasha Stevenson. Stream it on Hulu, Apple TV or anywhere you can find it. Go physical media! This signal has been transmitted by SpectreVision Radio Featuring Arkasha Stevenson Hosted by Mike Flanagan | @flanaganfilm Edited by Graham Reznick | @grahamreznick You can now join Directors Commentary with Mike Flanagan on Patreon! https://www.patreon.com/directorscommentarypod Learn more about your ad choices. Visit megaphone.fm/adchoices

Happy Halloween! Pierre and Sesali are in costume to talk about the rap girls taking over Homecoming season, Caresha's Hood Oprah tribute, but mostly Megan Thee Stallion's Act II. Purse First is the only podcast exclusively about female and queer rap, hosted by Sesali Bowen @badfatblackgirl and "Prince" Pierre Phipps @princecharmingp.  Watch a video recording of this episode on the Purse First YouTube channel! Join our Patreon for early access and exclusive bonus content! Follow #pursefirstshow on Instagram @PurseFirstShow.

Watch The Invisible Man with commentary from Mike Flanagan and Leigh Whannell. Stream it on Amazon, Apple or anywhere you can find it. Go physical media! Featuring Leigh Whannell Hosted by Mike Flanagan | @flanaganfilm Edited by Graham Reznick | @grahamreznick You can now join Directors Commentary with Mike Flanagan on Patreon! https://www.patreon.com/directorscommentarypod This signal has been transmitted by SpectreVision Radio Learn more about your ad choices. Visit megaphone.fm/adchoices