Podcasts about jakob l

Fimmtudagur 15. maí Trump, Vesturbugt, kvíði, Starmer, skoðanakúgun og kynjaþing Eiríkur Bergmann prófessor ræðir áhrif Trump á stjórnmálin utan Bandaríkjanna við Gunnar Smára. Gunnar Smári ræðir hverfið sem byggja á vestan við Slippinn við Reykjavíkurhöfn við Ástu Olgu Magnúsdóttur, íbúa á svæðinu og verkefnastjóra, Egil Sæbjörnsson, myndlistarmann og aðgerðasinna í byggingarlist og Pál Jakob Líndal, doktor í umhverfissálfræði og stofnanda Envalys. Sigurður Eyjólfur Sigurjónsson, íþrótta- og æskulýðsfulltrúi og rithöfundur ræðir við Oddnýju Eir um nýútkomna bók sína ,,Ég er ekki fullkominn” þar sem hann fjallar á persónulegan og skemmtilegan hátt um viðureign sína við kvíða. Gunnar Smári slær á þráðinn til Guðmundar Auðunssonar hagfræðings í London og ræðir við hann um stöðuna í breskum stjórnmálum, ekki síst hraðleið Verkamannaflokks Keir Starmer til hægri. Allt snýst um tengsl og klíkur á Íslandi er kemur að störfum og tækifærum segir nemi í félagsráðgjöf og ljósmyndari, Sigga Svanborgardóttir, sem býr í Danmörku. Björn Þorláks ræðir við hana. Oddný Eir ræðir við Auði Önnu Magnúsdóttur, framkvæmdastýru Kvenréttindafélags Íslands, um nýliðið kynjaþing, norræna kvennasamstöðu og stöðuna á kvennasamstöðunni.

Audun Kjus joins Jana Byars to talk about Adventures in the Play-Ritual Continuum (Utah State Press, 2025), eds. Audun Kjus, Jakob Löfgren, Cliona O'Carroll, Simon Poole & Ida Tolgensbakk. Utah State Press, 2025). The junctions between play and ritual are many and complex. Play is for fun and joy, but it also demands a total commitment and serious respect for rules. Rituals involve nearly endless varieties of social arrangements and can truly transform people, but they also include improvisation, testing, and pretending. Adventures in the Play-Ritual Continuum explores the connectivity between the playful and the ritualized through a fresh theoretical perspective, highlighting the creative messiness and the cultural paradoxes such intersections allow. The chapters span topics such as hen parties, marriage proposals, ash scatterings, extreme sports races, football fans, computer game festivals, celebrations of fandom, migration heritages, and antiracist protests. While the case studies are selected to show a range of diversity with various mergings of play, game, ritual, ceremony, rite, and ritualizing, the introductory and concluding discussions offer sharpened perspectives on common aspects. Following these excursions through the play-ritual continuum will be enjoyable for readers interested in how people make sense of their own existence and profitable for scholars in folklore, anthropology, religion, pedagogy, cultural studies, and social sciences and humanities more generally. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

Audun Kjus joins Jana Byars to talk about Adventures in the Play-Ritual Continuum (Utah State Press, 2025), eds. Audun Kjus, Jakob Löfgren, Cliona O'Carroll, Simon Poole & Ida Tolgensbakk. Utah State Press, 2025). The junctions between play and ritual are many and complex. Play is for fun and joy, but it also demands a total commitment and serious respect for rules. Rituals involve nearly endless varieties of social arrangements and can truly transform people, but they also include improvisation, testing, and pretending. Adventures in the Play-Ritual Continuum explores the connectivity between the playful and the ritualized through a fresh theoretical perspective, highlighting the creative messiness and the cultural paradoxes such intersections allow. The chapters span topics such as hen parties, marriage proposals, ash scatterings, extreme sports races, football fans, computer game festivals, celebrations of fandom, migration heritages, and antiracist protests. While the case studies are selected to show a range of diversity with various mergings of play, game, ritual, ceremony, rite, and ritualizing, the introductory and concluding discussions offer sharpened perspectives on common aspects. Following these excursions through the play-ritual continuum will be enjoyable for readers interested in how people make sense of their own existence and profitable for scholars in folklore, anthropology, religion, pedagogy, cultural studies, and social sciences and humanities more generally. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/folkore

Audun Kjus joins Jana Byars to talk about Adventures in the Play-Ritual Continuum (Utah State Press, 2025), eds. Audun Kjus, Jakob Löfgren, Cliona O'Carroll, Simon Poole & Ida Tolgensbakk. Utah State Press, 2025). The junctions between play and ritual are many and complex. Play is for fun and joy, but it also demands a total commitment and serious respect for rules. Rituals involve nearly endless varieties of social arrangements and can truly transform people, but they also include improvisation, testing, and pretending. Adventures in the Play-Ritual Continuum explores the connectivity between the playful and the ritualized through a fresh theoretical perspective, highlighting the creative messiness and the cultural paradoxes such intersections allow. The chapters span topics such as hen parties, marriage proposals, ash scatterings, extreme sports races, football fans, computer game festivals, celebrations of fandom, migration heritages, and antiracist protests. While the case studies are selected to show a range of diversity with various mergings of play, game, ritual, ceremony, rite, and ritualizing, the introductory and concluding discussions offer sharpened perspectives on common aspects. Following these excursions through the play-ritual continuum will be enjoyable for readers interested in how people make sense of their own existence and profitable for scholars in folklore, anthropology, religion, pedagogy, cultural studies, and social sciences and humanities more generally. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/anthropology

Audun Kjus joins Jana Byars to talk about Adventures in the Play-Ritual Continuum (Utah State Press, 2025), eds. Audun Kjus, Jakob Löfgren, Cliona O'Carroll, Simon Poole & Ida Tolgensbakk. Utah State Press, 2025). The junctions between play and ritual are many and complex. Play is for fun and joy, but it also demands a total commitment and serious respect for rules. Rituals involve nearly endless varieties of social arrangements and can truly transform people, but they also include improvisation, testing, and pretending. Adventures in the Play-Ritual Continuum explores the connectivity between the playful and the ritualized through a fresh theoretical perspective, highlighting the creative messiness and the cultural paradoxes such intersections allow. The chapters span topics such as hen parties, marriage proposals, ash scatterings, extreme sports races, football fans, computer game festivals, celebrations of fandom, migration heritages, and antiracist protests. While the case studies are selected to show a range of diversity with various mergings of play, game, ritual, ceremony, rite, and ritualizing, the introductory and concluding discussions offer sharpened perspectives on common aspects. Following these excursions through the play-ritual continuum will be enjoyable for readers interested in how people make sense of their own existence and profitable for scholars in folklore, anthropology, religion, pedagogy, cultural studies, and social sciences and humanities more generally. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/sociology

Paulus regnes ofte som den første teolog. Samtidig ser mange ham som en slags skurk som ødela Jesu gode budskap. De siste tiåra har mennesker langt utenfor kirke og religion fattet interesse for den store apostelen og nytestamentlige brevskriveren. Er han kanskje ikke skurk likevel? Og er det ok å lese Paulus helt ukristelig?Gjest i podkasten Dokka er Ole Jakob Løland, professor i KRLE ved Universitetet i Sørøst-Norge. Han er teolog og forfatter, og har blant annet skrevet boka En apostel for ateister. Paulus i moderne filosofi. Tenkere som refereres i episoden: Paulus, Friedrich Nietzsche, Sigmund Freud, Jacques Derrida, Giorgio Agamben, Jacob Taubes, Alain Badiou, Julia Kristeva, Slavoj Zizek, Krister Stendahl. Hosted on Acast. See acast.com/privacy for more information.

13 kvindelige musikere stiller sig frem og fortæller om krænkelser, upassende beskeder, uønskede berøringer og ulige spilleregler i DR-dokumentarserien 'Sexisme i musikbranchen'. Samtidig viser rapporter fra Analyse & Tal og KVINFO, DR og Bandakademiet, at kvindelige musikere ikke har de samme karrieremuligheder som deres mandlige kolleger, og selv etablerede kunstnere oplever chikane, og derfor vælger flere kvinder at forlade musikbranchen. Hvorfor oplever selv etablerede musikere at blive udsat for chikane, og hvad kan branchen gøre for at ændre på det? Og hvilken betydning har det, at det meste musik, der bliver spillet, er af mænd? Du kan blande dig i debatten ved at ringe ind fra 12:15-13:30 på 7021 1919 eller send en sms til 1212. Medvirkende: Nanna Øland, Oh Land, Lasse Lindholm, direktør for kommunikation i IFPI, Rikke Andersen, bestyrelsesleder i Dansk Live, Emma Winther, sangerinde, Gustav Lützhøft, fra Danmarks Radio, du ledende redaktionschef i DR Kultur, Debat & Musik, Jakob Løkkegaard-Friese, founder og direktør i WAS Entertainment, Mikkel Xavier, musikchef SmukFest og Anders Wahrén, programchef Roskilde Festival. Vært: Mathias Pedersen.

13 kvindelige musikere stiller sig frem og fortæller om krænkelser, upassende beskeder, uønskede berøringer og ulige spilleregler i DR-dokumentarserien 'Sexisme i musikbranchen'. Samtidig viser rapporter fra Analyse & Tal og KVINFO, DR og Bandakademiet, at kvindelige musikere ikke har de samme karrieremuligheder som deres mandlige kolleger, og selv etablerede kunstnere oplever chikane, og derfor vælger flere kvinder at forlade musikbranchen. Hvorfor oplever selv etablerede musikere at blive udsat for chikane, og hvad kan branchen gøre for at ændre på det? Og hvilken betydning har det, at det meste musik, der bliver spillet, er af mænd? Du kan blande dig i debatten ved at ringe ind fra 12:15-13:30 på 7021 1919 eller send en sms til 1212. Medvirkende: Nanna Øland, Oh Land, Lasse Lindholm, direktør for kommunikation i IFPI, Rikke Andersen, bestyrelsesleder i Dansk Live, Emma Winther, sangerinde, Gustav Lützhøft, fra Danmarks Radio, du ledende redaktionschef i DR Kultur, Debat & Musik, Jakob Løkkegaard-Friese, founder og direktør i WAS Entertainment, Mikkel Xavier, musikchef SmukFest og Anders Wahrén, programchef Roskilde Festival. Vært: Mathias Pedersen.

13 kvindelige musikere stiller sig frem og fortæller om krænkelser, upassende beskeder, uønskede berøringer og ulige spilleregler i DR-dokumentarserien 'Sexisme i musikbranchen'. Samtidig viser rapporter fra Analyse & Tal og KVINFO, DR og Bandakademiet, at kvindelige musikere ikke har de samme karrieremuligheder som deres mandlige kolleger, og selv etablerede kunstnere oplever chikane, og derfor vælger flere kvinder at forlade musikbranchen. Hvorfor oplever selv etablerede musikere at blive udsat for chikane, og hvad kan branchen gøre for at ændre på det? Og hvilken betydning har det, at det meste musik, der bliver spillet, er af mænd? Du kan blande dig i debatten ved at ringe ind fra 12:15-13:30 på 7021 1919 eller send en sms til 1212. Medvirkende: Nanna Øland, Oh Land, Lasse Lindholm, direktør for kommunikation i IFPI, Rikke Andersen, bestyrelsesleder i Dansk Live, Emma Winther, sangerinde, Gustav Lützhøft, fra Danmarks Radio, du ledende redaktionschef i DR Kultur, Debat & Musik, Jakob Løkkegaard-Friese, founder og direktør i WAS Entertainment, Mikkel Xavier, musikchef SmukFest og Anders Wahrén, programchef Roskilde Festival. Vært: Mathias Pedersen.

Tauche ein in eine inspirierende Episode von Stark im Sturm, in der Moderator Jens Alsleben gemeinsam mit den visionären Köpfen der MIT – Hans-Dieter Tenhaef, Marco Tenhaef, Jakob Löwenstein, Louisa Vauth und Karusch Galstjan, auch bekannt als die „jungen Wilden“ – tief in die Geheimnisse einer erfolgreichen Unternehmensnachfolge und die Dynamiken der Zusammenarbeit zwischen Generationen eintaucht. In dieser packenden Folge öffnen die Protagonisten für dich die Tür zu ihrer Welt und teilen ungeschminkt die entscheidenden Momente, die die „jungen Wilden“ ins Steuer des Unternehmens brachten, und enthüllen, wie diese mutige Entscheidung das Gesicht der Firma für immer veränderte. Erfahre aus erster Hand, wie eine systematische Führungsausbildung nicht nur das Spektrum an Kompetenzen erweitert, sondern auch tiefgreifende persönliche Einsichten freisetzt, die jeden Einzelnen und das gesamte Team stärken. Die Episode enthüllt die Schichten der Herausforderungen, die gemeinsam gemeistert werden mussten, zentriert um das essenzielle Element des Vertrauens, das ihre Zusammenarbeit definiert. Lass dich von ihren Ängsten, Erfahrungen und der gewonnenen Weisheit leiten, um die Brücke zwischen den Generationen mit Authentizität, Mut, Zielstrebigkeit und einer offenen Netzwerkmentalität zu schlagen. Erlebe hautnah: • Wie die Integration der „jungen Wilden“ in die Führungsebene den Weg für eine florierende Zukunft ebnete. • Die transformative Kraft der Führungsausbildung und des Coachings, die nicht nur Führungsqualitäten schärft, sondern auch persönliches Wachstum fördert. • Die unerlässliche Bedeutung der Akzeptanz durch Mitarbeiter und des teamübergreifenden Vertrauens für den Unternehmenserfolg. • Authentische Einblicke in die Herausforderungen und Erfolgsstrategien der Nachfolge. Bereite dich darauf vor, von dieser tiefgründigen Diskussion inspiriert zu werden, die nicht nur Einblicke in die Erfolgsgeheimnisse eines Familienunternehmens bietet, sondern auch universelle Lektionen über Führung, Vertrauen und den unaufhaltsamen menschlichen Geist offenbart. Verpasse nicht diese Episode von Stark im Sturm, die eine Schatzkiste an Erfahrungen und Ratschlägen bereithält, um dein Familienunternehmen mit Integrität, Innovation und Inklusivität in die Zukunft zu führen. Schalte ein, um die Stimmen zu hören, die das Morgen prägen. Viel Spaß beim Reinhören! Hier geht es zu den Profilen von Hans-Dieter und den jungen Wilden: https://www.linkedin.com/in/hans-dieter-tenhaef-6377bba2/ https://www.linkedin.com/in/marcotenhaef/ https://www.linkedin.com/in/jakob-löwenstein-38b09a22a/ https://www.linkedin.com/in/louisa-vauth-458137219/ https://www.linkedin.com/in/karusch-g-9b7ba022b/ Jens holt immer wieder sturmerprobte Gäste vors Mikrofon, die dir Einblick geben in ihre Gedankenwelt und Impulse, wie sie erfolgreich Herausforderungen bewältigt und sprichwörtlich den Sturm gemeistert haben. Jens erläutert dir außerdem immer wieder spannende wissenschaftlich fundierte Führungsmodelle und -methoden und gibt dir inspirierende Managementliteratur an die Hand, die dir und Deinen Mitarbeitenden helfen, stark im Sturm zu bleiben und eure Herausforderungen mit einer größeren Leichtigkeit, viel positiver Energie und Kreativität zu bewältigen. Jens ist neben seiner Autorentätigkeit erfolgreicher Führungsberater, Aufsichtsrat, Investor und begleitet als Positive Leadership- und Stärkencoach Unternehmer bei der erfolgreichen Implementierung stärkebasierter Führung. Vernetze Dich mit Jens auf LinkedIn: https://www.linkedin.com/in/jens-alsleben-stark-im-sturm/ Folge Jens Blog: https://www.starkimsturm.com/blog Hier geht's zu Jens' Webseite: www.starkimsturm.com

Við kynntumst verkefninu hundavinir í þættinum, það er hluti af vinaverkefnum Rauða krossins. Markmið þeirra er að sporna gegn félagslegri einangrun. Hundavinir er verkefni þar sem sjálfboðaliðar kíkja í heimsóknir á stofnanir eða til einstaklinga með hund, sé þess óskað. Þórdís Björg Björgvinsdóttir sjálfboðaliði kom í þáttinn í dag og sagði okkur frekar frá þessu verkefni. Því miður er fjöldi tilkynntra vinnuslysa til Vinnueftirlitsins rúmlega tvö þúsund á hverju ári, sem þýðir að meðaltali slasast sex einstaklingar í vinnuslysi á hverjum einasta degi. Í næstu viku verður forvarnaráðstefna VÍS haldin í þrettánda skiptið, hún er stærsta ráðstefna sinnar tegundar hér á landi og við fengum Helgu Rún Jónsdóttur, fulltrúa í gæða- og öryggisdeild Festis í viðtal, en hún ætlar á ráðstefnunni að fjalla um nýjar leiðir í forvarnar- og öryggismálum hjá Festi. Flestir verja stórum hluta tíma síns innandyra. Umhverfi okkar er samspil ólíkra þátta og hefur mismunandi áhrif á fólk. Þannig hefur umhverfið heima önnur áhrif en vinnuumhverfið og það er ólík upplifun að vera í skóla eða á sjúkrahúsi, í verslun eða leikhúsi. Páll Jakob Líndal er með doktorspróf í umhverfissálfræði frá Háskólanum í Sydney og hann er sérfræðingur í mati á sálfræðilegum áhrifum umhverfis á heilsu og vellíðan, hvort sem um er að ræða náttúru eða byggt umhverfi. Hann sagði okkur frá umhverfissálfræði í þættinum í dag. Tónlist í þættinum í dag: Ástarævintýri / Eyjólfur Kristjánsson (Eyjólfur Kristjánsson, Ingi Gunnar Jóhannsson og Aðalsteinn Ásberg Sigurðsson) Napur vindur / Úlfarnir (Ólafía Hrönn Jónsdóttir og Halldóra Geirharðsdóttir) Vonarströnd / Íkorni (Stefán Örn Gunnlaugsson) Three little birds / Bob Marley & The Wailers (Bob Marley) UMSJÓN: GUNNAR HANSSON OG GUÐRÚN GUNNARSDÓTTIR

Við kynntumst verkefninu hundavinir í þættinum, það er hluti af vinaverkefnum Rauða krossins. Markmið þeirra er að sporna gegn félagslegri einangrun. Hundavinir er verkefni þar sem sjálfboðaliðar kíkja í heimsóknir á stofnanir eða til einstaklinga með hund, sé þess óskað. Þórdís Björg Björgvinsdóttir sjálfboðaliði kom í þáttinn í dag og sagði okkur frekar frá þessu verkefni. Því miður er fjöldi tilkynntra vinnuslysa til Vinnueftirlitsins rúmlega tvö þúsund á hverju ári, sem þýðir að meðaltali slasast sex einstaklingar í vinnuslysi á hverjum einasta degi. Í næstu viku verður forvarnaráðstefna VÍS haldin í þrettánda skiptið, hún er stærsta ráðstefna sinnar tegundar hér á landi og við fengum Helgu Rún Jónsdóttur, fulltrúa í gæða- og öryggisdeild Festis í viðtal, en hún ætlar á ráðstefnunni að fjalla um nýjar leiðir í forvarnar- og öryggismálum hjá Festi. Flestir verja stórum hluta tíma síns innandyra. Umhverfi okkar er samspil ólíkra þátta og hefur mismunandi áhrif á fólk. Þannig hefur umhverfið heima önnur áhrif en vinnuumhverfið og það er ólík upplifun að vera í skóla eða á sjúkrahúsi, í verslun eða leikhúsi. Páll Jakob Líndal er með doktorspróf í umhverfissálfræði frá Háskólanum í Sydney og hann er sérfræðingur í mati á sálfræðilegum áhrifum umhverfis á heilsu og vellíðan, hvort sem um er að ræða náttúru eða byggt umhverfi. Hann sagði okkur frá umhverfissálfræði í þættinum í dag. Tónlist í þættinum í dag: Ástarævintýri / Eyjólfur Kristjánsson (Eyjólfur Kristjánsson, Ingi Gunnar Jóhannsson og Aðalsteinn Ásberg Sigurðsson) Napur vindur / Úlfarnir (Ólafía Hrönn Jónsdóttir og Halldóra Geirharðsdóttir) Vonarströnd / Íkorni (Stefán Örn Gunnlaugsson) Three little birds / Bob Marley & The Wailers (Bob Marley) UMSJÓN: GUNNAR HANSSON OG GUÐRÚN GUNNARSDÓTTIR

Weihnachten und Silvester sind traditionell fleischlastige Festtage: Von Fondue Chinoise über Filet und Rollschinkli landet in den nächsten Tagen und Wochen wieder viel Fleisch auf den Tellern. Rund 50 Kilogramm isst jede Schweizerin, jeder Schweizer im Durchschnitt pro Jahr. Eine neue Studie der Denkfabrik «Vision Landwirtschaft» zeigt: Fleisch essen kostet den Staat und die Allgemeinheit markant mehr als pflanzliche Kost – betreffend Klima, Pestizidbelastung, Biodiversität und Umwelt. Trotzdem buttert der Bund rund 80 Prozent der Subventionen in die Fleisch- und Milchproduktion, so die Studie. Die Sendung «Forum» diskutiert: Was wollen wir mit unseren Steuergeldern unterstützen? Braucht es mehr Subventionen für pflanzliche Lebensmittel und weniger für Fleisch und Milch? Gäste:  * Jakob Lütolf, Vorstand Schweizer Bauernverband und Landwirt * Laura Spring, Geschäftsführerin Vision Landwirtschaft und Agronomin ETH Diskutieren auch Sie mit und schreiben Sie uns Ihre Meinung per Email.

In this extra episode, our host Jakob Löwenbrand shares some insights and highlights inspired by our previous guests and episodes. By listening you take part in some snippets from episodes with Christopher Lochhead, Nancy Harhut and Geoffrey Moore. Don't forget to subscribe so you don't miss our many upcoming episodes guested by thought leaders in the fields of B2B tech marketing and sales!   If you want to know more or get in touch with Jakob, you'll find more information in the links below:   https://www.linkedin.com/in/jakoblowenbrand/ https://brightvision.com/about-us

Um helgina buðu Náttúruminjasafn Íslands og Náttúrufræðistofnun gestum og gangandi upp á aðstoðu og tæki til að greina helstu steintegundir á ÍSlandi undri dyggri leiðsögn sérfræðinga stofnananna. Bæði voru steinar á staðnum, en fólk kom líka með sína eigin. Svo virðist vera sem steinasafnarar séu víða og steinasöfn inn á mörgum heimilum. 19. nóvember er alþjóðlegur klósettdagur Sameinuðu Þjóðanna. Tæplega helmingur mannkyns býr við óviðunandi salernisaðstæður sem ógnar bæði heilsu þeirra og umhverfi. Hér á Íslandi erum við svo heppin að hafa bæði rennandi vatn og góða fráveitu en það hefur ekki alltaf verið raunin. Til okkar kemur Guðjón Friðriksson sagnfræðingur sem skrifaði fráveitusögu landsins en klukkan 5 í dag býður hann gestum í sögugöngu um ræsi miðborgarinnar. Ruslarabb - bökunarpappír. Páll Jakob Líndal, umhverfissálfræðingur verður svo með sinn pistil

Um helgina buðu Náttúruminjasafn Íslands og Náttúrufræðistofnun gestum og gangandi upp á aðstoðu og tæki til að greina helstu steintegundir á ÍSlandi undri dyggri leiðsögn sérfræðinga stofnananna. Bæði voru steinar á staðnum, en fólk kom líka með sína eigin. Svo virðist vera sem steinasafnarar séu víða og steinasöfn inn á mörgum heimilum. 19. nóvember er alþjóðlegur klósettdagur Sameinuðu Þjóðanna. Tæplega helmingur mannkyns býr við óviðunandi salernisaðstæður sem ógnar bæði heilsu þeirra og umhverfi. Hér á Íslandi erum við svo heppin að hafa bæði rennandi vatn og góða fráveitu en það hefur ekki alltaf verið raunin. Til okkar kemur Guðjón Friðriksson sagnfræðingur sem skrifaði fráveitusögu landsins en klukkan 5 í dag býður hann gestum í sögugöngu um ræsi miðborgarinnar. Ruslarabb - bökunarpappír. Páll Jakob Líndal, umhverfissálfræðingur verður svo með sinn pistil

Serie GENESIS - DAS BUCH VOM ANFANG mit Pastor Mag. Kurt Piesslinger 13.ISRAEL IN ÄGYPTEN Jakob erlebt die Erfüllung aller Träume. Merktext: 1.Mose 47,27 - So wohnte Israel in Ägypten im Lande Goschen, und sie hatten es inne und wuchsen und mehrten sich sehr. 13.2 Jakob lässt sich in Ägypten nieder Die Nachkommen Jakobs bekommen das beste Weideland in Ägypten. Wir wünschen Ihnen Gottes Segen! Für Videoaufnahme: https://vimeo.com/721727397

Serie GENESIS - DAS BUCH VOM ANFANG mit Pastor Mag. Kurt Piesslinger 13.ISRAEL IN ÄGYPTEN Jakob erlebt die Erfüllung aller Träume. Merktext: 1.Mose 47,27 - So wohnte Israel in Ägypten im Lande Goschen, und sie hatten es inne und wuchsen und mehrten sich sehr. 13.2 Jakob lässt sich in Ägypten nieder Die Nachkommen Jakobs bekommen das beste Weideland in Ägypten. Wir wünschen Ihnen Gottes Segen! Für Videoaufnahme: vimeo.com/721727397

Osnabrücks Nachtbürgermeister Jakob Lübke zieht zum Jahresende positive Bilanz +++ Was war da noch mal: unser regionaler Jahresrückblick

Aujourd'hui, Arnaud Romain lit l'article de Pascale Pascariello: Creutzfeldt-Jakob: l'Inrae freine l'expertise judiciaire sur le décès d'une de ses laborantines publié sur Mediapart le 1er août 2021.

Silja Bára Ómarsdóttir, prófessor í stjórnmálafræði við HÍ: viðhorf Íslendinga til alþjóðamála. Ný könnun leiðir ýmislegt forvitnilegt í ljós um viðhorf Íslendinga til alþjóðamála. Silja fór yfir helstu atriðin. Erla Erlendsdóttir og Kristín Guðrún Jónsdóttir: Erla og Kristín voru að gefa út nýtt rit; Á fjarlægum ströndum, tengsl Spánar og Íslands í tímans rás og fara meðal annars yfir fjölbreytt samskipti landanna í gegnum tímans rás. Páll Jakob Líndal umhverfissálfræðingur með pistil um samspil náttúru, umhverfis, bygginga og mannsins.

Silja Bára Ómarsdóttir, prófessor í stjórnmálafræði við HÍ: viðhorf Íslendinga til alþjóðamála. Ný könnun leiðir ýmislegt forvitnilegt í ljós um viðhorf Íslendinga til alþjóðamála. Silja fór yfir helstu atriðin. Erla Erlendsdóttir og Kristín Guðrún Jónsdóttir: Erla og Kristín voru að gefa út nýtt rit; Á fjarlægum ströndum, tengsl Spánar og Íslands í tímans rás og fara meðal annars yfir fjölbreytt samskipti landanna í gegnum tímans rás. Páll Jakob Líndal umhverfissálfræðingur með pistil um samspil náttúru, umhverfis, bygginga og mannsins.

Við fræddumst um hugleiðslu og núvitund í þættinum í dag. Tolli Morthens myndlistarmaður kom í þáttinn en hann hefur stundað búddisma og núvitundarhugleiðslu í hartnær tvo áratugi og t.d. kennt og leitt hugleiðslu í fangelsum landsins. Tolli hefur haldið fjölda námskeiða og fyrirlestra um hugleiðslu og fræddi okkur um núvitund í þættinum. Við veltum fyrir okkur sálfræðilegum áhrif umhverfis og bygginga á líðan fólks í dag. Páll Jakob Líndal, doktor í umhverfissálfræði og aðjúnkt við sálfræðideild HÍ heldur námskeið á vegum Endurmenntunar HÍ um þessi áhrif. Á námskeiðinu kynnir Páll, skoðar og ræðir áhrif náttúru og byggðs umhverfis á andlega, líkamlega og félagslega líðan fólks út frá umhverfissálfræði. Hann kom í þáttinn í dag og gaf okkur smá forskot á sæluna. Við fengum póstkort frá Magnúsi R. Einarssyni á Spáni í dag. Í korti dagsins var sagt frá kuldakasti sem er væntanlegt um næstu helgi. Það er mikill og vaxandi skjálfti í spænskri pólitík vegna kosninga sem hafa verið boðaðar í Madridarhéraði í byrjun maí. Það var líka sagt frá ótta Spánverja við Þjóðverjana sem nú hafa fengið leyfi til að ferðast til Spánar um páskana, en Mallorca er sem fyrr efst á vinsældalista Þjóðverja. Kórónusmit er miklu útbreiddara í Þýskalandi um þessar mundir en á Spáni og þess vegna eru Spánverjar nú á milli tveggja elda, óttans við smit og óttans vegna tekjutaps í ferðaþjónustunni. UMSJÓN GUNNAR HANSSON OG GUÐRÚN GUNNARSDÓTTIR

Við fræddumst um hugleiðslu og núvitund í þættinum í dag. Tolli Morthens myndlistarmaður kom í þáttinn en hann hefur stundað búddisma og núvitundarhugleiðslu í hartnær tvo áratugi og t.d. kennt og leitt hugleiðslu í fangelsum landsins. Tolli hefur haldið fjölda námskeiða og fyrirlestra um hugleiðslu og fræddi okkur um núvitund í þættinum. Við veltum fyrir okkur sálfræðilegum áhrif umhverfis og bygginga á líðan fólks í dag. Páll Jakob Líndal, doktor í umhverfissálfræði og aðjúnkt við sálfræðideild HÍ heldur námskeið á vegum Endurmenntunar HÍ um þessi áhrif. Á námskeiðinu kynnir Páll, skoðar og ræðir áhrif náttúru og byggðs umhverfis á andlega, líkamlega og félagslega líðan fólks út frá umhverfissálfræði. Hann kom í þáttinn í dag og gaf okkur smá forskot á sæluna. Við fengum póstkort frá Magnúsi R. Einarssyni á Spáni í dag. Í korti dagsins var sagt frá kuldakasti sem er væntanlegt um næstu helgi. Það er mikill og vaxandi skjálfti í spænskri pólitík vegna kosninga sem hafa verið boðaðar í Madridarhéraði í byrjun maí. Það var líka sagt frá ótta Spánverja við Þjóðverjana sem nú hafa fengið leyfi til að ferðast til Spánar um páskana, en Mallorca er sem fyrr efst á vinsældalista Þjóðverja. Kórónusmit er miklu útbreiddara í Þýskalandi um þessar mundir en á Spáni og þess vegna eru Spánverjar nú á milli tveggja elda, óttans við smit og óttans vegna tekjutaps í ferðaþjónustunni. UMSJÓN GUNNAR HANSSON OG GUÐRÚN GUNNARSDÓTTIR

CS:GO domination, Publicly-listed Team Astralis In this episode, Chris talks with Jakob L. Kristensen - Co-Founder at Astralis. Available on Apple Podcasts, Spotify and Anchor Show Notes Guest - Jakob L. Kristensen Astralis LinkedIn Host - Chris Smith: LinkedIn Twitter --- Send in a voice message: https://anchor.fm/big-esports/message

För en tid sedan tog ett forskarlag i Lund fram en rapport som undersökt hur virus sprids när man sjunger. Vilka låtar är säkrast ? Dessutom - Kan 13-åringar själva hantera bokningen av covid-test? För många är sång ett viktigt inslag i julfirandet, både när det gäller eventuella snapsvisor och julsånger. För en tid sedan publicerade ett forskarlag i Lund en rapport som undersökt hur corona-viruset sprids när människor sjunger. Det visade sig att det spelar roll hur starkt vi sjunger men även att en del konsonanter är värre än andra. Idag reder vi ut alla detaljer, kommer Thomas börja sjunga på ett annat sett nu? Vi gästas av Jakob Löndahl forskare i aerosolteknologi vid Lunds Universitet. I lördags berättade regeringen att man hoppas att den nya pandemilagen som var tänkt att börja gälla i mars kanske kan bli verklighet redan i januari. Hur snabbt är det möjligt att stifta en ny lag undrar vi? För att få svar på det har vi bjudit in Johan Welander, kammarsekreterare vid Centralkansliet. När en ung människa fyller tretton är han eller hon själv ansvarig för att sköta sina kontakter med vården och det här gäller även när ett corona-test ska beställas. Vad gör en förälder till en trettonåring som inte vill boka ett test? Medverkar gör Sofie Zetterström affärsområdeschef från Vårdguiden och Matilda Wallin, sjuksköterska på Gottsundaskolan. Programledare: Louise Epstein  Bisittare: Thomas Nordegren Producent: Maria Bertell Research: Deniz Merdol

Bryndís Loftsdóttir, félagi íslenskra bókaútgefenda: fyrirbærið jólabókaflóðið, áhrif þess, þróun og áskoranir samtímans, staða höfunda og vilji lesenda. Kristjana Motzfeldt: Börnin á Grænlandi og afsökunarbeiðni Dana. Páll Jakob Líndal, umhverfissálfræðingur með pistil um áhrif umhverfisins á andlega líðan.

Bryndís Loftsdóttir, félagi íslenskra bókaútgefenda: fyrirbærið jólabókaflóðið, áhrif þess, þróun og áskoranir samtímans, staða höfunda og vilji lesenda. Kristjana Motzfeldt: Börnin á Grænlandi og afsökunarbeiðni Dana. Páll Jakob Líndal, umhverfissálfræðingur með pistil um áhrif umhverfisins á andlega líðan.

Heiða María Sigurðardóttir dósent í sálfræði við Háskóla Íslands, doktor í taugavísindum og ein forsvarsmanna Rannsóknamiðstöðvar um sjónskynjun: Hvað er les- og skrifblinda? Hvers vegna hrjáir það fólk og er eðlilegt að það verði fyrir aðkasti vegna þess? Nýverið gaf Bubbi Morthens út textaverk sem hann kallar: Veggur hinna skrifblindu, en þar má sjá búta úr glósubók sem hann samdi marga af sínum frægustu textum í. Mikið er um stafsetningarvillur í textunum, enda Bubbi les- og skrifblindur, en hann segist ekki skammast sín lengur fyrir það og því fái allar villur að standa óbreyttar. Heiða útskýrir hvernig slík blinda virkar og hvort hún segi til um getu fólks á einhverju öðru sviði. Elín Agla Briem: Grannaheimsókn. Elín flutti nýlega úr strandasýslu til reykjavíkur, úr gamla kaupfélagshúsinu í norðurfirði, og í gömlu hverfisbúðina í skjólunum í vesturbæ. Páll Jakob Líndal, umhverfissálfræðingur flytur pistil um áhrif umhverfis á fólk og líðan þess.

Heiða María Sigurðardóttir dósent í sálfræði við Háskóla Íslands, doktor í taugavísindum og ein forsvarsmanna Rannsóknamiðstöðvar um sjónskynjun: Hvað er les- og skrifblinda? Hvers vegna hrjáir það fólk og er eðlilegt að það verði fyrir aðkasti vegna þess? Nýverið gaf Bubbi Morthens út textaverk sem hann kallar: Veggur hinna skrifblindu, en þar má sjá búta úr glósubók sem hann samdi marga af sínum frægustu textum í. Mikið er um stafsetningarvillur í textunum, enda Bubbi les- og skrifblindur, en hann segist ekki skammast sín lengur fyrir það og því fái allar villur að standa óbreyttar. Heiða útskýrir hvernig slík blinda virkar og hvort hún segi til um getu fólks á einhverju öðru sviði. Elín Agla Briem: Grannaheimsókn. Elín flutti nýlega úr strandasýslu til reykjavíkur, úr gamla kaupfélagshúsinu í norðurfirði, og í gömlu hverfisbúðina í skjólunum í vesturbæ. Páll Jakob Líndal, umhverfissálfræðingur flytur pistil um áhrif umhverfis á fólk og líðan þess.

Í þættinum í dag fengum við til okkar fulltrúa frá tveimur liðum í Olísdeild kvenna til þess að spjalla við okkur. Jakob Lárusson og Fanney Þóra Þórsdóttir frá FH voru hjá okkur í fyrri hluta þáttar en svo komu þau Gunnar Gunnarsson og Rakel Sigurðardóttir frá Haukum í seinni hlutann.

Hör om studien som har visat att coronaviruset kan färdas över fyra meter inomhus. Medverkande: Camilla Widebeck Vetenskapsradion, Jakob Löndahl, docent i aerosolteknik vid Lunds universitet, Staffan Normark, professor i medicinsk mikrobiologi vid Karolinska institutet samt Urban Kumlin, läkare och virolog knuten till universitetet och sjukhuset i Umeå. Katarina Sundberg  katarina.sundberg@sverigesradio.se

Stolthet, frustration och arbetsglädje. Alla känslor finns när pandemiforskningen beskrivs från några olika horisonter i forskarvärlden. Jakob Löndahl i Lund jobbar med att kartlägga virus i sjukhusmiljö. En kunskap som vården skrek efter i våras när det handlar om viruset SARS-CoV2. Han har förslag på vad som kunde ha gjorts för att resultaten skulle ha kunnat levereras snabbare. Tove Fall professor i molekylär epidemiologi efterlyser ett forum för utbyte av idéer mellan forskare och expertmyndigheter. På Vetenskapsrådet  är man nöjd med hur omställningen till pandemiforskning har fungerat i Sverige. 35 forskare med miljonbidrag från Vetenskapsrådet kunde ändra inriktning på sin forskning och satsa på covid-19. 23 fick nya bidrag från Vetenskapsrådet utifrån  specifika idéer som fötts kring pandemin. Vetenskapsrådets generaldirektör Sven Stafström tänker att regeringen borde ha en vetenskaplig rådgivare eller ett vetenskapligt råd för att fungera ännu bättre under en pandemi eller vid annan typ av kris. Hör forskningsminister Matilda Ernkrans kommentar i Vetenskapsradion Hälsa.

Dr Carolyn Lam: Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. I'm Dr Carolyn Lam, associate editor from the National Heart Center and Duke National University of Singapore. Dr Greg Hundley: And I'm Dr Greg Hundley, director of the Pauley Heart Center at BCU Health in                                                     Richmond, Virginia. Dr Carolyn Lam: So Greg, guess what? We are going to be discussing predicting the benefit of evolocumab therapy in patients with atherosclerotic disease using a genetic risk score. That's our featured paper this week coming from the results of the FOURIER trial. I bet you can't wait to discuss it, but I'm not going to let us until we talk about some of the papers in today's issue. Do you have one? Dr Greg Hundley: Yes, Carolyn, but first I'm going to get a cup of coffee because there's a lot of data in this one. This study is from the ODYSSEY trial and it involves alirocumab and it's from Dr Charles Paulding. Remember Carolyn, the ODYSSEY trial was a randomized double-blind placebo-controlled trial comparing alirocumab, a PCSK9 inhibitor or placebo in 18,924 patients with acute coronary syndrome and elevated atherogenic lipoproteins despite optimized statin treatment. And the primary endpoint of this trial comprise death from coronary artery disease, non-fatal MI, ischemic stroke, or unstable angina requiring hospitalization. Now Carolyn, this is a sub-study and it was performed an A genome wide polygenic risk score for coronary artery disease comprising 6,579,025 genetic variants. And they were evaluated in 11,953 patients with available DNA samples. Analysis of the MACE risks, all those outcomes together, was performed in placebo treated patients while treatment benefit analysis was performed across all the patients. Dr Carolyn Lam: Ooh, so what did they find? Dr Greg Hundley: Well, Carolyn, both the absolute and relative reduction of MACE by alirocumab compared to placebo was greater in high versus low PRS patients. Those genetic, polygenetic risk scores combined in the patients. There was an absolute reduction by alirocumab in high versus low PRS groups of 6% and 1.5% respectively, and relative risk reduction in the alirocumab of 37% in the high PRS group versus 13% in the low PRS group. And so Carolyn, these results suggest the possibility of an independent tool for risk stratification using sort of precision medicine by selecting those using these genetic constructs, who may be more likely to benefit from this form of therapy. Dr Carolyn Lam: Wow Greg, that is really interesting. I genuinely think that our world is moving towards precision medicine and this really, really speaks to remember that feature paper also talking about genetic risk scores, but from the FOURIER trial. But before we get to that, I've got a basic science paper. Now this one provides insights into the mechanisms underlying age related hypertension. And it's from Dr Ying Yu and colleagues from Tianjin Medical University who hypothesize that since proinflammatory cytokines increase in T lymphocytes with aging and prostaglandin D2 suppresses T helper 1 cytokines through the D-prostanoid receptor 1, that this axis in T cells may play a role in age related hypertension. Dr Greg Hundley: Ah, Carolyn. What did they find in this study? Dr Carolyn Lam: Prostaglandin D2 biosynthesis and D-prostanoid receptor 1 expression, were both markedly decline in CD4 positive T cells from older humans and aged mice. D-prostanoid receptor 1 depletion in these CD4 positive T cells, exaggerated age dependent blood pressure elevation in mice by increasing tumor necrosis factor alpha and interferon gamma secretion. Whereas its over expression showed the opposite effect and its activation suppressed TH1 cytokines. These results really indicate that D-prostanoid receptor 1 and its downstream pathway may serve as an attractive immuno-therapeutic target for age dependent hypertension. Dr Greg Hundley: Oh wow. Very insightful Carolyn. Well, I've got a basic science paper to go over and it's from professor Kinya Otsu from Kings College London. This study addresses the mechanism of ongoing inflammation within the hearts of patients with cardiomyopathy. The study involves the assessment of Regnase-1 and RNAs involved in the degradation of a set of pro inflammatory cytokine messenger RNAs in immune cells. And the study involves the role of Regnase-1 in non-immune cells such as cardiomyocytes. Dr Carolyn Lam: Wow. Dr Greg Hundley: The degradation of cytokine messenger RNA by Regnase-1 and cardiomyocytes plays an important role in restraining sterile information in failing heart. Once the inflammatory cascade gets going, this is that constant inflammation that's ongoing. In addition, the Regnase-1 mediated pathway might be a therapeutic target to treat patients with heart failure as adeno-associated virus 9 mediated cardiomyocyte targeted gene delivery of Regnase-1 or administration of anti-IL-6 receptor antibody, attenuated the development cardiomyopathy induced by severe pressure overload in wild type mice. Dr Carolyn Lam: Wow, that's really interesting. I find this whole field of inflammation in heart failure of course, of key interest, but I'm going to next tell you about the results of the FUEL trial, which is the Fontan Udenafil Exercise Longitudinal trial. Dr Greg Hundley: Tell us about the Fontan operation. Dr Carolyn Lam: Aha, I thought you may ask, Greg. Well, the Fontan operation to remind us all, really creates a total cavopulmonary connection and a circulation in which the importance of pulmonary vascular resistance is therefore magnified. Over time, the circulation needs to deterioration of cardiovascular efficiency associated with a decline in exercise performance. This FUEL trial and reported this time by David Goldberg and colleagues from the Children's Hospital of Philadelphia was a phase 3 clinical trial, which randomized 400 patients with Fontan physiology from 30 sites in North America and the Republic of Korea. The participants were randomly assigned to Udenafil at 87.5 milligrams twice daily or placebo. And the primary outcome was the between group difference in change in oxygen consumption with peak exercise. Dr Greg Hundley: Hmmm, very large important trial it seems like Carolyn. What did they find? Dr Carolyn Lam: Treatment with Udenafil did not result in a significant increase in peak oxygen consumption, which was the primary outcome, but did result in improvements in measures of exercise performance at the anaerobic threshold, which was a secondary outcome. Udenafil was well tolerated with side effects limited to those previously known to be associated with phosphodiesterase type 5 inhibitors. These results and future perspectives are discussed an editorial called FUELing the Search for Medical Therapies in Late Fontan Failure, by Doctors Gewillig and De Bruaene. Dr Greg Hundley: Very nice, Carolyn. Now how about the rest of the journal? Dr Carolyn Lam: Oh well I want to tell you about this in-depth review by Dr Rosenkranz and it's entitled, Systemic Consequences of Pulmonary Hypertension and Right-Sided Heart Failure. Very intriguingly, talking about non-cardiac features, as well as cardiac, of right heart failure, a real, real must read with beautiful figures. In the cardiovascular case series we discuss a case of left ventricular non-compaction and cardiogenic shock by Dr Shenoy. There are also two research letters I want to tell you about one by Dr Gillinov on the accuracy of the Apple watch for detection of atrial fibrillation. And this time looking at the Apple watch series 4, which interestingly employs electrodes to generate a single lead ECG and provides two mechanisms for rhythm assessment. Won't tell you more. You got to pick up this beautiful letter. The next is by Dr Mazer on the effect of empagliflozin on erythropoietin levels IN stores and red blood cell morphology in patients with type II diabetes and coronary artery disease. And this really provides evidence to suggest that SGLT 2 inhibition with empagliflozin may stimulate erythropoiesis via an early increase in erythropoietin production in people with diabetes. Dr Greg Hundley: You know Carolyn, we just keep hearing more about EMPA and DAPA and they are just going to really pave the way I think for a whole new class of agents that we're going to be using frequently. I've got a couple letters in the mailbox and one is by Sugimoto and Taniguchi regarding the article, Internal Versus External Electrical Cardioversion of Atrial Arrhythmia in Patients with Implantable Cardio Defibrillators, a randomized clinical trial. And then also there's another research letter by Dr Hiroshi Sugimoto from Kobe Red Cross Hospital with a response by Jakob Lüker from University of Cologne. What a great issue. How about we proceed to that feature article? Dr Carolyn Lam: You bet. Can a genetic risk score identify individuals who will derive greater benefit from PC SK9 inhibition? Well guess what? We're going to find out now in our feature discussion. So pleased to have with us the first and the corresponding authors of our feature paper, Dr Nicholas Marston and Dr Christian Ruff, both from the TIMI study group in Brigham and Women's Hospital and Harvard Medical School and also to have our lovely associate editor, Dr Svati Shah from Duke University in Durham, North Carolina. Welcome everyone. Nick, could I get you started with telling us about this exciting analysis that you did from the FOURIER trial? Dr Nicholas Marston: The FOURIER trial was a 27,000 patient cardiovascular outcomes trial that studied the PC SK9 inhibitor, evolocumab and it demonstrated a significant reduction in major adverse cardiovascular events in patients who had established atherosclerotic disease. And in the study, there was a 15% relative risk reduction and a 2% absolute risk reduction, which earned it a class 2 recommendation for very high-risk patients with atherosclerosis in the recent cholesterol management guidelines. And what we've done in previous lipid trials is we studied the interactions between genetic risk and treatment benefit. For example, in 2015 we showed that patients with high genetic risk, those in the top 20% of genetic risk, had the greatest benefit from statin therapy in terms of both absolute and relative risk reductions. And so now we have the opportunity with evolocumab and data from the FOURIER trial to ask the same question of PC SK9 inhibitor. That is, could a genetic risk score identify patients who will drive a greater treatment benefit and we hypothesize that like statins, there would in fact be a significant interaction between genetic risk and therapeutic benefit. Dr Carolyn Lam: That's so cool Nick. But could I ask, the question always comes, is it nature versus nurture? And so I really love the way that you dealt with the clinical risk factors as well. Could you maybe walk us through that and then tell us the results? Dr Nicholas Marston: Yes, absolutely. We for this study, kind of had two objectives. One was to look at risk prediction and then the other look at treatment benefit and using a genetic risk score for both. However, we wanted to go further than just use the genetic risk score. We wanted to incorporate clinical risk factors since that's how we would do it as physicians in the clinic. We would have not just genetic risk data in front of us but also clinical data. And so when we were grading a patient's risk using genetic risk, we also factored in if they had multiple clinical risk factors. And what we found by combining both genetic and clinical risk was that there was a significant gradient of risk across these risk categories. That is patients who were without high genetic risk and without multiple clinical risk factors actually had no benefit from evolocumab over the 2.2-year follow-up period. However, those without high genetic risk, but who did have multiple clinical risk factors, derived an intermediate benefit. About a 13% relative risk reduction and 1.4% absolute risk reduction. And then it was the high genetic risk group, independent of whether or not they had multiple clinical risk factors that had the largest benefit from evolocumab with a relative risk reduction of 31%, absolute risk reduction of 4% and the number needed to treat of 25. And that's actually a twofold greater benefit than was seen in the overall FOURIER trial population. Dr Carolyn Lam: That's really stunning results. Now I know Svati's going to have questions for us, so maybe I should invite you Svati, just put these results into context and let the audience know what we were thinking as editors when we saw this brilliant paper. Dr Svati Shah: Yeah, thanks Carolyn. And I think Nick has done a fantastic job of describing the exciting results from this paper and just kind of taking a step back to help the audience understand what we're talking about when we're talking about genetics. For decades, we've been trying to figure out the genetics of heart disease and we're not talking about the genetics of things that are really rare like long QT syndrome, but the genetics of just common complex heart diseases. And amongst the scientific community, we've tried all different ways of sort of analyzing these data and so I want to make sure that everybody who's listening understands the novelty of really looking at these polygenic risk scores. Where we have now come to understand that it's not a single gene, it's not even two genes, that it's multiple variants and multiple genes and when they're combined, that's when you really have the power to understand how it might be useful in terms of how we take care of patients. Really important with how Nick and Christian have laid out this really nice paper as well as their prior work in statins, is that not only did they show that these polygenic risk scores are associated with cardiovascular outcomes or even different amongst whether you get treated with the drug or whether you don't, but really importantly they're getting it clinical utility, not only with regards to showing that they compare it to a clinical risk score, but really showing that if you use these polygenic risk scores, you can identify patients who may derive the greatest benefit from PC SK9 inhibitors. And importantly in their paper, they show that if you have low polygenic risk score and low clinical risk score, you may not derive benefit from PC SK9 inhibitors. With all the caveats that this is a secondary prevention population, so I really applaud Christian and Nick and his team for the nice work that was done. Dr Carolyn Lam: Oh, couldn't agree more, Svati. You know what I was very struck with too, because some people go, I may have a genetic risk. Maybe I could undo it or somehow overcome it with my clinical risk factors. And that's why I really appreciated that they showed that it was additive, and genetics still matter even if you have risk factors and vice versa. That was really cool. Christian, could I ask you to maybe describe a bit, what kind of genetic risk score this was and maybe perhaps point out some of the limitations therefore of what you studied. Dr Christian Ruff: As Svati mentioned, this is really a quickly evolving field. We now have the ability to either genotype or sequence all of the variation that makes us different from one another. Our susceptibility to disease as well as our potential benefit for treatment. We had for this study, looked at several different risk scores. The one we focused on was a coronary artery disease genetic risk score that had 27 different variants that had been shown to predict having a cardiac event, both in primary and secondary populations. And we have previously identified patients who may have been at a higher risk who received greater benefit from statin therapy. And in this study, we actually compared this 27 variant genetic risk score with actually a much larger score of over six million variants. And interestingly, the two scores performed fairly similar with respect for risk prediction. One of the big questions going forward is, we have lots of ways to develop genetic risk scores, how many different variants do we need? What more information do we have with more complicated scores? And I think Svati really hit on a really critical point is that really this study is really layering in genetic risk on top of clinical risk factors, which we can easily assess at the bedside. And I think what's reassuring to patients is that not only is genetic risk able to give us much more information for prognosis, but that this risk is modifiable. People think that their genetic risk, they're sort of born with it and there's nothing that they can do about it. But in this study, as Nick pointed out, even over a very short period of time with powerful lipid lowering therapy with a PC SK9 inhibitor, we essentially reduced these patients at high genetic risk to the risk of the very low risk patients on placebo. I think this is a reassuring message that genetics plays an important role for risk prediction and it identifies patients who we might target for more intensive therapy and that we can potentially reduce that risk even though that risk is based on the DNA that they're born with. Dr Carolyn Lam: Indeed. That's a great point. And Svati, I'm sure you were thinking along those lines when you invited that beautiful editorial by Doctors Daniel Raider and Michael Levin. But Svati, would you like to comment on your thoughts on, is this ready for prime time? Dr Svati Shah: I think that's the key question. What Christian and Nick and his team have done is take us a big step forward in how we use these polygenic risk scores. I think there still are many skeptics amongst the genetic scientific community about, well great, you can look at 27 variants and some of these polygenic risk scores, you're looking at a million things. How do we actually use that to take care of patients? I actually want to turn this back, that question back around Carolyn, and I'd like to ask Christian next, what are the next steps? There are a lot of cardiologists who if you're listening to this podcast, should we all run out and get our patient's genotype to order this genetic chip so that we can figure out what their polygenic risk score is? Dr Christian Ruff: Yeah, that's a great question and I could start off and then hand off to Nick, but I think one of the key questions is obviously there are a lot of genetic risk scores and I don't think as a field that we've come up with which one we really should implement in clinical practice. There's still a lot of fine tuning and figuring out which score gives us the most amount of useful information. And then I think as something that you had mentioned that these scores are generated in both a healthy cohort population and now, we're looking at it in clinical trials and there's no sort of reference. Like when we have a blood test and we say, "If your hemoglobin A1C is above or below this number that means that you have diabetes." And we haven't figured out, what are the actual thresholds that you use for these genetic risk scores that you can implement broadly across different patient populations. There's still a lot of work that needs to be done to make these scores ready for prime time. This is really setting the stage. Is this something that we should be doing? And I think these studies and others say that the data looks great that we should be doing this, but we haven't yet figured out the logistics of which score and how do we actually reference to population. Dr Nicholas Marston: Yeah, I agree with Christian definitely that we need to figure out what's the optimal genetic risk tool and for which population and what the cut points are. And then I think another piece that's going to be very important moving forward is doing a lot of this work and studying in non-European ancestry and cohorts and populations. Because most of the work done so far in discovery has been in databases such as the UK Biobank. And that limits us in our analyses to European ancestry patients. And so, I think for this to go to prime time, we want to be able to offer it to all of our patients. And so that means making sure we have scores that fit all populations, not just primary and secondary, but also all different types of ancestry. Dr Carolyn Lam: Oh, I'm so glad you mentioned that, Nick. That was exactly on my mind coming from Asia. And the other thing of course, would be cost effectiveness of these approaches. Oh my goodness. I wish we had all the time in the world to talk about this more. The implications are enormous, but just let me thank you on behalf of all of us for publishing this remarkable paper in Circulation. Audience, you've been listening to Circulation on the Run. Don't forget to tune in again next week. Dr Greg Hundley: This program is copyright, the American Heart Association 2020.  

Varför spelar en vuxen man fantasyspel med plastråttor? Varför borde vi sluta tala om toxisk maskulinitet? Och vad händer när män får frågan: Hur var det att vara pojke? Vi dyker in i pojkarnas värld och undrar vilka förväntningarna är på dagens män.Med barn- och ungdomsforskaren Harry Lunabba (SSKH vid Helsingfors universitet) och folkloristen Jakob Löfgren (Åbo Akademi/Lunds universitet). Mer info om avsnittet: sls.fi/vetskap***Vetskap är podden där humanister och samhällsvetare berättar om sin forskning och ger nya perspektiv på både välkända ämnen och överraskande fenomen. Programvärd: Hanna Nordenswan.

Páll Jakob sagði frá uppvextinum í Reykjavík, menntaskólaárunum á Akureyri, Kiss áhuganum, söngnámi og ýmsu fleiru. Hann sagði frá fjölskyldunni áhugamálunum og ýmsu fleiru. Árelía Eydís sagði frá uppvexti, námi starfi, ritstörfum og ýmsu öðru.

Páll Jakob sagði frá uppvextinum í Reykjavík, menntaskólaárunum á Akureyri, Kiss áhuganum, söngnámi og ýmsu fleiru. Hann sagði frá fjölskyldunni áhugamálunum og ýmsu fleiru. Árelía Eydís sagði frá uppvexti, námi starfi, ritstörfum og ýmsu öðru.

Páll Jakob sagði frá uppvextinum í Reykjavík, menntaskólaárunum á Akureyri, Kiss áhuganum, söngnámi og ýmsu fleiru. Hann sagði frá fjölskyldunni áhugamálunum og ýmsu fleiru. Árelía Eydís sagði frá uppvexti, námi starfi, ritstörfum og ýmsu öðru.

Bjarna F. Einarssyni fornleifafræðingur: Við uppgröft á Stöð í Stöðvarfirði hafa fundist ýmsir gripir - meðal annarra gripa sem hafa fundist er skutull væntanlega notaður til að veiða sel og smáhveli. Ingimar Eydal skólastjóri Sjúkraflutningaskólans: Skólinn útskrifaði 147 manns í vor, af ýmsum stigum, meðal annars vettvangsliða. Konum hefur fjölgað meðal nemenda undanfarin ár. Guðrún Línberg Guðjónsdóttir: Málfarsmínútan - fjallað er um hringveginn. Páll Jakob Líndal doktor í umhverfissálfræði: Hvernig má nota sýndarveruleika til að skipuleggja byggð svo að fólki líði vel í umhverfi sínu?

Við ræddum skipulagsmál í gærmorgun við Magneu Guðmundsdóttur arkitekt þar sem hún lýsti m.a. yfir ánægju með framkvæmdir og uppbyggingu við Hafnartorg. Ekki eru allir á sama máli og í dag kom Páll Jakob Líndal doktor í umhverfissálfræði til okkar en hann hefur m.a. bent á að taka þurfi meira tillit til umhverfissálfræði við hönnun húsa og skipulag hverfa og sveitarfélaga. Stjórn Félags kvenna í atvinnurekstri gagnrýnir harðlega hvernig tekið hefur verið á málum hjá orku náttúrunnar og orkuveitu reykjavíkur þar sem yfirmenn hafa sýnt kvennkyns undirmönnum sínum óviðeigandi hegðun. Rakel Sveinsdóttir, formaður stjórnar FKA, er þeirrar skoðunar að Orkuveitumálið sé bara byrjunin og að nú þurfi að rjúfa þagnarmúrinn sem umlykur aðra vinnustaði. VIð ræddum við hana í þættinum Búast má við hraungosi á Reykjanesi hvenær sem er, en síðast gaus á því svæði árið 1879. Mikilvægt er að meta áhættuna og vinna viðbragðsáætlanir að mati Þorvaldar Þórðarsonar eldfjallafræðings við jarðvísindastofnun Háskóla Íslands. Þorvaldur heimsótti okkur og sagði okkur meira. Sævar Helgi Bragason kíkti í sitt vikulega vísinda spjall og þar var m.a. rætt um horframleiðslu og áskoranir við að vera kvefaður úti í geimnum. Tónlist: KK - Bráðum vetur. Bubbi - Foxtrot. Baggalútur - Sorrí með mig. KISS - Hard Luck Woman. Júníus Meyvant - Beat silent need. R.E.M. - Pop Song 89. GDNR - Hvað ef (ft. Auður). Ellie Goulding - Lights. Jamiroquai - Cloud 9.

Kári Aðalsteinsson, garðyrkjustjóri Kirkjugarða Reykjavíkur, Kristinn Haukur Skarphéðinsson, vist- og fuglafræðingur Náttúrufræðistofnun og Páll Jakob Líndal, doktor í umhverfissálfræði: Áhrif leiðinlegs veðurfars þetta vorið á gróður, dýr og menn. Ásbjörn Björgvinsson, forstjóri Votlendissjóðs: Úthlutanir úr votlendissjóði Málfarsmínúta Vera Knútsdóttir félag Sameinuðu þjóðanna á Íslandi og Gígja Gunanrsdóttir, verkefnistjóri heilsueflandi samfélags hjá Embætti Landlæknis: heimsmarkmið Sameinuðu þjóðanna.

Helga Birgisdóttir er hjúkrunarfræðingur, myndlistarkona, ljósmóðir, NLP meðferðar- og markþjálfi og frumkvöðull SMILER. Hún heldur bæði fyrirlestra og námskeið sem stuðla að andlegri og líkamlegri heilsu. M.a. kennir hún aðferð Byron Katie (höfund bókarinnar Elskaðu það sem er) The Work sem er áhrifarík leið til að losa sig við streitu og öðlast innri frið og hamingju. Helga sagði okkur sögu sína, hvernig hún reis upp, virkjaði sköpunarkraft sinn og fann leiðina að hamingjunni. Umhverfið og hvernig mannvirki eru hönnuð hefur áhrif á líðan og sálarlíf fólks. Samt er ekki tekið mikið tillit til þess við skipulag hverfa og hönnun mannvirkja. Fjallað var um umhverfissálfræði á heilsuvaktinni í dag Bergljót Baldursdóttir ræddi við Páll Jakob Líndal dr. í umhverfissálfræði. Stefán, Ingólfur, Kristín og Iðunn Öddu- og Steinsbörn, bjóða til kvöldvöku á morgun í Hannesarholti, sem þau nefna Tungu-mál. Systkinin úr Tungu hafa sýslað margt um dagana, á ferilskrá þeirra gefur að líta ótrúlega fjölbreytta blöndu af hinu og þessu, til að nefna örfá dæmi, ritstjórn, þýðingar, ýmsar lækningar og síldarsöltun, kennsla á öllum aldursstigum, talsíma- og sendilsstörf, sýnataka og efnagreining, verksmiðjuvinna, grafið fyrir sjónvarpsstreng, gamalmenna gætt í Danaveldi, og fleira. Þær Kristín og Iðunn komu í þáttinn í dag. Umsjón í dag, Guðrún Gunnarsdóttir og Gunnar Hansson

Intervjuer: Andreas Hoftun, John Olav Einemo, Jakob Løvstad. I denne ukas MMA-Revyen: Vi går gjennom detaljene rundt TUF-finalen, som gav oss vår første kvinnelige TUF-vinner. Både Holdsworth og Pena overbeviste, men som forventet var det Nate Diaz som stjal showet. Vi skal også høre fra instruktørene fra den første samlingen av MMA-landslaget, som fant sted på Lørenskog hos Novus Academy, samt snakke med kollega Sverre Humberset Hagen, som rapporterte fra samlingen om hans opplevelser derfra. Vi skal også se over Fight Night 33 fra Australia, der mange tungpustede heavyweights (og Shogun Rua) skal ut i aksjon, på det som ser ut som et lovende Fight Night-kort. Som vanlig starter vi med lytterspørsmål og ukas poll, der Dana White og Ronda Rousey står i fokus. Spørsmål og kommentarer til mma@srib.no

A short introduction on how to apply test-driven development methodologies to CSS and HTML using http://jakobloekke.github.io/tdcss.js/ More info at: https://fronteers.nl/congres/2013/jam-session/test-driven-css

A short introduction on how to apply test-driven development methodologies to CSS and HTML using http://jakobloekke.github.io/tdcss.js/ More info at: https://fronteers.nl/congres/2013/jam-session/test-driven-css

MMA-Revyen tar stilling til lytternes ønske for nestemann ut mot Anthony Pettis, den nye tittelholderen i lightweight, og diskuterer divisjonens fremtid. Vi diskuterer også alle pluss og minus ved enda en ny sesong av The Ultimate Fighter og trekker noen paralleller fra denne sesongen bak i historien. Det har vært uttakssamling for det nye landslaget i amatør-MMA i Oslo i helgen og Revyens reporter var på stedet. Sverre Humberset Hagen snakker med håpefulle utøvere og landslagssjefen selv: Jakob Løvstad. I andre halvdel av sendingen snakker vi gjennom de viktigste kampene i uken som gikk, og ser frem mot UFC FN 28 fra Belo Horisonte, der Glover Teixera møter Ryan Bader. Spørsmål eller kommentarer til sendingen: mma@srib.no

Gjest: Ny norsk landslagssjef i MMA, Jakob Løvstad. Revyen er endelig tilbake med prate-abstinenser klar til å knekke ned og fordøye UFC FN 26 (FOX Sports 1 lanseringen) i all herligheten den representerer. Er Matt Brown klar for en GSP-aktig utfordring? Kanskje ikke, men vi vet i alle fall nå at Travis Browne fortjener en topp 5 plassering i heavyweight. Blant andre nyheter takler Connor McGregor presset, mens Uriah Hall knakk sammen, alt dette og en inngående prat med ny Norsk landlagssjef i MMA, Jakob Løvstad i denne sesongens første utgave av MMA-Revyen.

Idag har vi hatt MMA-legende, forfatter, filosof og coach Jakob Løvstad i studio til en utrolig givende og interessant podcast. Her er noe av høydepunktene du kan glede deg til å høre om… Jakobs vei mot å vinne beltet i FinnFight to ganger Inside info om dagens største stjerner i UFC Viktigheten av inner-game i MMA-sporten […] The post Hakeslepp #25 [Gjest: Jakob Løvstad] appeared first on Morten Hake and The New Paradigm Podcast.