Live Longer World

Can we detect cancer so early such that we find the very first cell of cancer? Not just stage 1 cancer, but the first cell of cancer.In this episode, Dr. Michael Levin and I speak with Dr. Azra Raza. She is an oncologist pioneering early detection of cancer using electric signals. So far, our best solution to curing cancer has been to detect it early, and she wants to take this further, by nipping cancer at the very first cell.Her story with cancer is also deeply personal as she lost her husband to the disease. You can see in the episode how much she cares about solving cancer through early detection, and how aggrieved she is about the fact that not only have we made zero progress on cancer in the last 100 years, but doctors are also not focused on cancer prevention.Dr. Raza is also the author of the book The First Cell: And the Human Costs of Pursuing Cancer to the Last.Episode Show Notes: https://livelongerworld.com/p/arazaFind me: https://x.com/aasthajs My longevity products: https://www.livelongerworld.com/p/2024TIMESTAMPS:0:00 New theory of cancer1:45 What causes cancer? 5:39 Hybrid cells in cancer 11:16 Why do cancer cells become immortal?14:14 Detecting the first cell of cancer17:09 Stress causes cancer cells to fuse21:40 Cancer drugs don't work universally25:54 Personalization of early cancer detection29:29 Detect cancer early using electrics35:46 Anguish of cancer patients39:06 Cancer progress hasn't moved in 100 years44:04 Doctors don't think of cancer prevention46:54 First Cell Therapeutics - Azra's company50:55 What is the first cell stage of cancer?54:55 Advice for cancer patientsAASTHA, LIVE LONGER WORLD:Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/Instagram: https://www.instagram.com/aasthajs/LINKS:Michael Levin: https://twitter.com/drmichaellevinAzra Raza: https://azraraza.com/Azra Raza book The First Cell: https://amzn.to/4jGJzoJEpisode Show Notes: https://livelongerworld.com/p/arazaRELATED EPISODES:Keto & Metabolic Therapy for Cancer | Dr. Thomas Seyfried: https://open.spotify.com/episode/7tYdjcJ3G4tqbAx9Z6Bix2?si=gboyPAiLQrqg-y5YEKQiQQWhy Viruses Could Be the Cause of Chronic Disease | Dr. Paul Ewald: https://open.spotify.com/episode/2OdYInlzTy2zG3Mi6TgADY?si=Gnbg7efNSy21bS3q0c23jg

What if chronic diseases like cancer and Alzheimer's are caused by infections we've overlooked? We assume chronic disease is caused by genetics and / or lifestyle. However, evolutionary biologist Dr. Paul Ewald says latent viruses and pathogens play a critical hidden role in many diseases. For example, we already know that Human Papillomavirus (HPV) causes cervical cancer. And research indicates how the EBV virus shows up in Multiple sclerosis, and chlamydia pneumonia shows in Alzheimer's. Deeper investigation into viruses and disease is warranted and will help with better diagnosis and treatment.Dr. Paul Ewald is also the author of Plague Time: The New Germ Theory of Disease, and Evolution of Infectious diseases. Episode Show Notes: https://livelongerworld.com/p/pewaldFind me: https://x.com/aasthajs My longevity products: https://www.livelongerworld.com/p/2024TIMESTAMPS:0:00 Role of infection in chronic disease is neglected2:40 Role of viruses in Alzheimer's10:50 Connections between Alzheimer's, diabetes, cardiovascular disease15:57 Genes cannot explain the full reason for disease20:47 Strong association between Alzheimer's, chlamydia pneumonia, and APOE428:16 Multiple sclerosis and EBV virus35:08 Latent viruses may in fact be active & cause cancer41:41 Sexually- transmitted pathogens correlated with cancer46:50 Viruses that cause cancer (EBV & breast cancer)53:09 Hodgkin's lymphoma and virus57:15 Stanford study showing EBV as leading cause of MS1:00:19 Do viruses attack the mitochondria and cause cancer1:01:38 Glioblastoma and virus / antiviral treatment1:07:07 Virus vs. oncogenes causing cancer1:14:17 Breast cancer BRAC1 mutations & virus association1:15:59 Vaccines against viruses1:17:56 Practical steps if you test positive for infectious viruses1:24:57 Could cancer relapse be due to persistent virus1:27:48 Protect the immune system1:29:38 Areas Dr. Ewald is excited aboutAASTHA, LIVE LONGER WORLD:X: https://x.com/aasthajs Newsletter: https://livelongerworld.com/Instagram: https://www.instagram.com/aasthajs/PAUL EWALD LINKS:Plague Time: The New Germ Theory of Disease: https://amzn.to/3FXjOSuEvolution of Infectious diseases: https://amzn.to/3FYaqOvEpisode Show Notes: https://livelongerworld.com/p/pewaldALSO WATCH:Keto & Metabolic Therapy for Cancer | Dr. Thomas Seyfried: https://open.spotify.com/episode/7tYdjcJ3G4tqbAx9Z6Bix2?si=biOOH1e5RpeZduLJv2fPHw

What if our cells have memory and cognition, which changes how medicine is done?In this conversation with Dr. Pamela Lyon and Dr. Michael Levin, we discuss:- Cognition and creativity is not merely associated with the brain and nervous system- Implications of this view of cognition for regenerative medicine and longevity- Is stress response the source of our creativity?Episode Show Notes: https://livelongerworld.com/p/plyonFind me: https://x.com/aasthajs My longevity products: https://www.livelongerworld.com/p/2024TIMESTAMPS:0:00 Intro, Basal cognition1:00 Our view of cognition is incorrect8:50 What does biology have to say about cognition?12:12 Cognition in xenobots14:20 Cognition and cooperation in microbes30:03 Bioelectricity and cognition33:58 Is stress response the source of our creativity?43:27 Mike's paper: Stress-sharing as a cognitive glue47:31 Implications of cognition not only being associated with brain56:55 Cognition in AI1:02:33 View of cognition in the EastAASTHA, LIVE LONGER WORLD:Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/Instagram:https://www.instagram.com/aasthajs/LINKS:Michael Levin: https://twitter.com/drmichaellevinPamela Lyon: https://www.adelaide.edu.au/directory/pamela.lyon#Episode Show Notes: https://livelongerworld.com/p/plyonALSO WATCH:Michael Levin & Denis Noble on What Biology Needs to Advance Longevity: https://open.spotify.com/episode/49WaTa4Vl67FU4zjjX1H6F?si=x1rjzVocS2OjSVdxpzNt5g

We're only just waking up to the benefits of sunlight and red light for mitochondrial health, lowering blood glucose, and potentially treating Parkinson's disease and cancer.Dr. Glen Jeffery is at the leading edge of this research. We discuss:- Health benefits of sunlight and red light- Harmful effects of blue light & LEDs- In the 2nd half of the podcast, I ask him rapid fire practical questions that everyone wants to know about light, ranging from how much sunlight should one get to what time of day is best for infrared light exposure. Episode Show Notes: https://livelongerworld.com/p/gjefferyFind me: https://x.com/aasthajs TIMESTAMPS: 0:00 Intro0:59 Light impact on public health3:08 Light research is understudied, mitochondria is impacted by light6:05 Red and blue light impacts on mitochondria8:25 Benefits of red light - wound healing, lower glucose15:09 Are there downsides to red light?16:59 Does time of day impact red light benefits?22:05 Red light and cancer26:00 Blue light is making you pre-diabetic37:46 n=1 light experiments39:22 Mitochondria & Longevity46:21 “Sunlight offers a unique package”Rapid fire questions:53:40 Is sunlight good enough for red light?55:10 How much sunlight do we need?56:07 When should you get sunlight?56:55 Should you worry about afternoon sunlight?58:57 Can you get sunlight on cloudy days?59:38 Does sunscreen mitigate benefits of sunlight?1:00:12 Should you not wear caps and sunglasses in sunlight1:01:43 Clothing and sunlight1:05:52 Sunlight through window?1:06:16 Are blue light blocking glasses helpful? (see 1:19:31 for more context)1:08:17 Do Artificial sunlight lamps work?1:08:51 What wavelength red light is the best?1:10:56 Time in front of red light device1:12:41 Body exposure to red light1:15:37 Lighting at home at night1:19:31 Differences in blue light for mitochondria vs. circadian biology1:24:18 Stop using LEDs1:25:24 Does light impact the bioelectrics of the mitochondria?1:26:55 Mitochondria in melatonin mop up ROS1:31:29 Benefits of fire light?1:35:33 Open questions on light and health1:37:28 Support Live Longer WorldAASTHA, LIVE LONGER WORLD: X: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ DR. GLEN JEFFERY: Bio page: https://profiles.ucl.ac.uk/7465-glen-jeffery/publicationsALSO WATCH:- Keto & Metabolic Therapy for Cancer | Dr. Thomas Seyfried: https://open.spotify.com/episode/7tYdjcJ3G4tqbAx9Z6Bix2?si=rHlCwLVqQHqiOB7yTVBtgQ

Dr. Thomas Seyfried challenges the existing paradigm that says cancer is a genetic disease. He says that instead cancer is caused by damage to the mitochondria. Understanding this completely overturns the management and prevention of cancer. He is a Professor of biology, genetics, and biochemistry at Boston College. He has over 150 peer-reviewed publications and is also the author of books such as, ‘Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer'. WE DISCUSS: - Why cancer is not a genetic disease - Why cancer is a metabolic disease originating from damage to the mitochondria - How metabolic therapy, management of glucose and glutamine, can be used to manage cancer - His December 2024 paper outlining a proposal for ketogenic metabolic therapy in glioblastoma Episode Show Notes: https://livelongerworld.com/p/tseyfried Find me: https://x.com/aasthajs TIMESTAMPS: 0:00 Cancer is not a genetic disease 5:04 Origins of somatic mutation theory of cancer 8:04 Mitochondrial damage causes cancer 13:42 Is mitochondrial dysfunction involved in every cancer 16:14 Mitochondria in cancer cells ferment 21:52 Target glucose and glutamine to manage cancer 28:51 Hyperbaric Oxygen therapy for cancer 31:04 December 2024 study: Role of glutamine in cancer 33:35 Can metabolic therapy be done at any stage of cancer 36:44 Combine chemotherapy with metabolic therapy 38:05 Drugs to target glutamine 40:30 People will say “I want metabolic therapy” 44:04 “Failure to understand biology” 47:48 National Cancer Institute's take on Dr. Seyfried's theory 49:34 Why does Peter Attia think cancer is a genetic disease 53:09 “I think about this 24/7; we're right!” 55:56 Glioblastoma treatment protocol study 59:22 Resistance to breakthrough ideas in science 1:01:40 Radiation fuels cancer! 1:04:52 Current standard of care is responsible for poor survival rate in glioblastoma 1:07:14 Metabolic therapy for epilepsy, Parkinson's, Alzheimer's 1:12:22 How to prevent cancer 1:13:49 Young, healthy individuals in their 20s, 30s with cancer 1:15:05 Resources on following metabolic therapy 1:17:43 How to support Dr. Seyfried's research 1:18:51 New cancer questions Dr. Seyfried is researching 1:21:32 Closing thoughts AASTHA, LIVE LONGER WORLD: X: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ DR. THOMAS SEYFRIED: X: https://x.com/tnseyfried Bio page: https://www.bc.edu/bc-web/schools/morrissey/departments/biology/people/faculty-directory/thomas-seyfried.htmlCancer as a Metabolic disease book: https://amzn.to/3WBF31D RELATED EPISODES: The Cancer-Diet Connection & Otto Warburg - Nobel Prize Scientist under Hitler | Sam Apple, Author of Ravenous Modified Ketogenic Diet for Optimal Health & Exercise | Dr. Dominic D'Agostino Ketogenic Diet for Brain Health & Longevity | Dr. Dominic D'Agostino The Evolutionary Theory of Cancer | Charley Lineweaever Bioelectricity and Cancer w/ Michael Levin

Denis Noble and Michael Levin - two great minds in biology come together on Live Longer World. Denis Noble is a renowned biologist and pioneer in systems biology, known for his groundbreaking work on the electrical activity of the heart and his influential contributions to the understanding of biological systems. Denis is an advocate for taking a systems integrative approach to biology, as opposed to the reductionist gene-centric view that has dominated the field due to Neo-Darwinism. The gene-centric view has failed us in advancing progress on many diseases, and we need to now take a systems based approach focused on functional networks within biological systems. Michael Levin is an American developmental and synthetic biologist at Tufts University, where he is the Vannevar Bush Distinguished Professor. His research is focused on bioelectricity and he is my co-host for this podcast. We discuss: - DNA is not the blueprint of life - Why biology's reductionist approach is flawed - The errors in Neo-Darwinism - Epigenetic inheritance - How to advance the cure of diseases Episode Show Notes: https://livelongerworld.com/p/dnoble Find me: https://x.com/aasthajs TIMESTAMPS: 0:00 Denis as Mike Levin's hero 0:10 Denis's journey to systems biology; cell voltage is a global property of the cell 3:45 Advice to young researchers pursuing systems biology 7:00 “Absolutely everything is wrong with Neo-Darwinism” 14:10 Epigenetic inheritance 19:12 Genetic vs. other information used by organisms 23:48 Biology textbooks have to expand beyond DNA in 50 years 25:03 Epigenetic processes are ubiquitous 28:58 If not DNA, what is the blueprint of life 36:15 Rewriting biology textbooks is fundamental 39:57 “A lot of time has been wasted” (in biology) 46:52 Darwin on the “Origin of Species” 55:38 “Unfortunate that Philosophy and science have diverged” 1:00:31 Importance of Functional networks; DNA does not predict disease AASTHA, LIVE LONGER WORLD: Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ LINKS: Michael Levin: https://twitter.com/drmichaellevin Denis's book Dance to the Tune of Life: https://a.co/d/3hvh5JW Episode Show Notes: https://livelongerworld.com/p/dnoble Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8?si=WrQ_iI8ABbG6eibm

This interview is part of my series with Dr. Michael Levin where we interview significant people in the history of developmental bioelectricity. Dr. Mustafa Djamgoz was one of the first people to study the role of ion channels and bioelectricity in cancer, which he initially documented in a 1995 paper. His research showed that there was an uptake in voltage-gated sodium channels in all types of cancer metastasis, except prostate cancer, highlighting the significant role of studying ion channels in cancer. Simply put, the spread of cancer cells is linked to increased activity in sodium ion channels, which regulate electrical currents in our cells. Episode Show Notes: https://livelongerworld.com/p/mdjamgoz Find me: https://x.com/aasthajs Background on the bioelectricity series & 1st episode with Dr. Richard Nuccitelli: https://youtu.be/DtUqOwTRvz0?si=3OJryM0yJjzfQtfo TIMESTAMPS: 0:00 Playing with radios at age 17 to bioelectricity cancer research 4:31 Advice for young people entering bioelectricity 9:02 Biophysics and Cancer neuroscience 17:55 Role of bioelectricity in cancer 27:02 Cancer metastasis and ion channels 28:49 Sodium channel uptake and cancer invasiveness 36:59 Ranolazine, potential anti-metastatic drug 43:45 Funding for bioelectricity cancer research 50:21 Advice for cancer patients AASTHA, LIVE LONGER WORLD: Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ Michael Levin: https://twitter.com/drmichaellevin Mustafa's publications: https://profiles.imperial.ac.uk/m.djamgoz/publications Mustafa's book Beat Cancer: https://www.amazon.com/Beat-Cancer-Regain-Control-Health-ebook/dp/B00CU8QBAS Episode Show Notes: https://livelongerworld.com/p/djamgoz Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8?si=WrQ_iI8ABbG6eibm

Dr. Alfonso Martinez Arias is a development biologist and the author of the book The Master Builder: How the New Science of the Cell Is Rewriting the Story of Life. He also co-authored the biology textbook Principles of Development, which was awarded the Royal Society of Biology book prize. Episode Show Notes: https://livelongerworld.com/p/aarias OVERVIEW: Each of our cells has the same DNA. Yet they somehow differentiate into different body parts - eyes, ears, skin, and so on. There is no information in the DNA that tells our cells what to be. How then do they do it? This is just one example of how contrary to what many might think, DNA does not explain every problem state in biology. Biology has placed too much emphasis on our genes, trying to explain every disease state using genes, when the answer might not reside with them. What if answers to these questions lies with cells? Even though Dr. Martinez started off as a geneticist, he decided to pivot to understand the properties of cells better. By understanding our cells better, we can make further progress in understanding disease, longevity, and development. Towards the end, we also talk about Alfonso's fascinating work on gastruloids which are a model to unravel the mysteries of embryonic development, and understand how humans are formed. This conversation is about the cell's eye view of biology, and how the gene's eye view of biology might have mislead us. We also talk about why the popular selfish gene theory espoused by Richard Dawkins is incomplete. Looking beyond genes is instrumental to making progress in longevity. Episode Show Notes: https://livelongerworld.com/p/aarias Find me: https://x.com/aasthajs TIMESTAMPS: 0:00 Intro 1:15 DNA does not make us unique 5:28 Cells use our genes 10:42 “We have overstretched what genes can explain” 15:41 Relation between genes and cells 20:28 What about the role of epigenetics? 22:42 Cells use mechanical and chemical signals 27:34 Thoughts on bioelectricity and Michael Levin 32:28 Emergence of cells 38:10 Importance of biophysics; What is life? 42:32 Is cancer when cells lose control? 47:58 Richard Dawkins' Selfish Gene is Incomplete 54:11 But what if genes control development? 57:29 How to complete the selfish gene view? 1:02:05 Cell's eye view of biology 1:04:48 Understanding embryonic development; gastruloids 1:18:15 Questions Dr. Alfonso is pursuing1:19:47 Thoughts from Feynman AASTHA, LIVE LONGER WORLD: X: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ DR. ALFONSO MARTINEZ ARIAS: Master Builder book: https://www.amazon.com/Master-Builder-Science-Rewriting-Story/dp/1541603273 X: https://x.com/AMartinezArias Bio page: https://www.icrea.cat/Web/ScientificStaff/alfonso-martinez-arias-352001

The following is a fascinating interview with Dr. Charley Lineweaver, who worked with Paul Davies on his work on cancer which we discuss. Episode Show Notes: https://livelongerworld.com/p/clineweaver Topics include: - the evolutionary and atavistic theory of cancer - the incorrectness of the somatic mutation theory of cancer - a novel take on attacking the weakness of cancer - how embryogenesis could be viewed as cells reverting to old memory - the origins of multicellularity - “Cancer cannot do anything new” The atavistic theory of cancer states that cancer cells revert to an old memory they have from billions of years, but forget the new memory. The old memory pertains to constant cell proliferation, which happened as single-celled creatures, and in fact in embryogenesis as well. The new memory pertains to regulating cell proliferation and cells knowing when to stop cellular division. In cancer, it seems like cells forget this new memory and revert to the old memory. This theory has many interesting explanations and predictions which we dive into in the conversation. Enjoy! Episode Show Notes: https://livelongerworld.com/p/clineweaver Find me: https://x.com/aasthajs TIMESTAMPS: 0:00 Background in astrobiology 1:53 Evolutionary theory of cancer 6:22 Atavistic model: Cancer cells go back to “original state” 9:50 Atavistic theory vs. Cancer 14:44 Somatic Mutation Theory of Cancer is Wrong 22:36 Disagreement with Mike Levin's work 24:17 Attack the weakness of cancer 27:45 Vaccine for cancer 38:08 Wound healing and cancer 41:23 Why new genes are more susceptible to damage 45:26 Origins of multicellularity 48:49 Predictions of Atavistic model 53:45 Cancer cells spread 56:52 Cell proliferation, Cancer, Hayflick limit 58:54 Doctors are not trained in evolution AASTHA, LIVE LONGER WORLD: Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ DR. CHARLEY LINEWEAVER: Website: https://researchers.anu.edu.au/researchers/lineweaver-ch Papers referenced: - Cancer progression as a series of atavistic reversions: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860064/ - Targeting cancer's weaknesses, not its strengths: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282648/

This is the third in my series with Dr. Michael Levin where we interview significant people in the history of developmental bioelectricity. Ken Robinson has a long list of accomplishments in the bioelectricity field, covering the role of electric fields in guiding cell migration and more generally the function of electrogenic epithelia in embryogenesis. This is about a ~1 hour conversation in which he talks about his background, the history of the field, and his time in Lionel Jaffe's lab. Episode Show Notes: https://livelongerworld.com/p/krobinson Find me: https://x.com/aasthajs Background on the bioelectricity series & 1st episode with Dr. Richard Nuccitelli: https://www.livelongerworld.com/p/rnuccitelli TIMESTAMPS: 0:00 Intro 0:38 Ken's background - From physics to bioelectricity 6:10 Bioelectricity in the era of the “genetic code” 10:27 Ken's first experiments in ion movement using light 23:25 Proton pump and its significance 26:07 Neurons respond to electrical signals 36:26 Working in Lionel Jaffe's lab 47:39 Mike Levin as an undergrad 48:49 Membrane potential left-right asymmetry in cells 52:59 Epithelia is powerfully electrogenic 57:49 Advances for bioelectricity 59:27 Underrated people in the field AASTHA, LIVE LONGER WORLD: Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Michael Levin: https://twitter.com/drmichaellevin Mike's bibliography of bioelectricity: https://thoughtforms.life/my-reference-lists-whole-endnote-library-and-bibliography-on-bioelectromagnetics/ Episode Show Notes: https://livelongerworld.com/p/krobinson Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8?si=WrQ_iI8ABbG6eibm

This is the second of several interviews Michael Levin and I will do with significant people in the history of developmental bioelectricity. Min Zhao's work is focused on the role of ion currents and applied electric fields in cell migration and wound repair. Episode Show Notes: https://livelongerworld.com/p/mzhao Find me: https://x.com/aasthajs Background on the bioelectricity series & 1st episode with Dr. Richard Nuccitelli: https://youtu.be/DtUqOwTRvz0?si=3OJryM0yJjzfQtfo TIMESTAMPS: 0:00 Min's background from trauma surgery to bioelectricity 5:14 Bioelectricity in wound healing 13:51 Potential and challenges of bioelectricity in wound healing 21:40 Min's take on Robert Becker's work 24:53 Scientists in the field Min drew got inspired by 29:36 The era before Lionel Jaffe 32:39 Experiments in wound healing using bioelectricity 45:43 Min's current explorations AASTHA, LIVE LONGER WORLD: Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Michael Levin: https://twitter.com/drmichaellevin Min Zhao: https://health.ucdavis.edu/dermatology/faculty/zhao.html Episode Show Notes: https://livelongerworld.com/p/mzhao Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8?si=WrQ_iI8ABbG6eibm

Stephanie Seneff is the pioneer in raising concerns around glyphosate, a chemical and active ingredient in RoundUp and other pesticides, which has practically infiltrated our food system, water bodies, and soil. Glyphosate has been linked to several diseases including liver disease, autoimmunity, neurological disorders, reproductive issues, microbiome problems, and more. Dr. Stephanie Seneff has spent 10+ years researching glyphosate's harmful impact on our health, and documented her findings in her book Toxic Legacy: How the Weedkiller Glyphosate is Destroying our Health and the Environment. More recently, Stephanie has been doing research on deuterium (a hydrogen isotope in the body) and how glyphosate can cause an excess of deuterium, potentially leading to cancer and other health consequences. Glyphosate is affecting each one of us. It's worth paying attention to this toxic chemical. Episode Show Notes: https://livelongerworld.com/p/sseneff Find me (Aastha) on X: https://x.com/aasthajs DR. STEPHANIE SENEFF LINKS: Website: https://stephanieseneff.net/ X: https://x.com/stephanieseneff Book: https://www.amazon.com/Toxic-Legacy-Stephanie-Seneff/dp/1603589295/ AASTHA, LIVE LONGER WORLD: X: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ Airchat: https://www.getairchat.com/aasthajs TIMESTAMPS: 0:00 Autism in children, vaccines, glyphosate 2:30 Aluminum and fluoride in water 3:47 Glyphosate in our food and its toxicity 6:05 Celiac's link to glyphosate 8:25 Glyphosate impacting collagen in our bodies 12:55 Soil regeneration after glyphosate 15:24 Breaking down glyphosate in our waterways 16:36 Glyphosate causing sulfate deficiency; cruciferous veggies 18:43 Sulfate powers bioelectricity in our cells; Gerald Pollack 21:23 Avoid sunscreen? 22:25 Deuterium and its toxicity 25:20 How Stephanie started looking at Deuterium 26:36 Low deuterium water good for health? 29:25 Excess deuterium causing cancer 30:52 Stephanie's wild theory on curing cancer 35:19 What else causes increase in deuterium 35:38 Glyphosate in rain water 36:25 PSCSK9 inhibitors harmful with glyphosate 38:49 Solutions to avoid glyphosate 42:23 U.S. stopped Mexico banning glyphosate Episode Show Notes: https://livelongerworld.com/p/sseneff

This is the first of several interviews Michael Levin and I will do with significant people in the history of developmental bioelectricity. Richard Nuccitelli is a legend, having invented (with Lionel Jaffe, in 1974) the Vibrating Probe - a technique that allowed the non-invasive sensing of ion currents around living tissues. This is about a ~1 hour conversation in which he talks about his background, the history of the field, and his current clinical work on the bioelectrics of cancer. Episode Show Notes: https://livelongerworld.com/p/rnuccitelli Find me: https://twitter.com/aasthajs BACKGROUND: In 2022, I interviewed Dr. Michael Levin on his work on bioelectricity in cells and how that has the potential to solve cancer and aging. Since then, Mike has also appeared on Lex Fridman and many other podcasts talking about his revolutionary work. Amongst all the podcasts I did, Mike's work struck me as profound yet underappreciated. The field of biology has focused on the DNA and the relevance of the electric currents in our cells is not appreciated. Yes, the electrical energy powering our cells is what keeps us alive! Earlier this year, I decided to dive deeper into bioelectricity. I'm starting by exploring the history of the field in conjunction with Michael Levin. We're doing a series of interviews talking to scientists in the field to understand the origins of the field, bottlenecks, progress so far, and what the future could look like. Today's interview is the first in the series with Dr. Richard Nuccitelli. TIMESTAMPS: 0:00 Intro to History of Bioelectricity Series 1:09 How Rich got interested in bioelectricity 4:34 Bioelectrics didn't make it to biology literature 7:55 Vibrating probe use cases 10:20 Bioelectrics in 1970s 13:37 Why is bioelectrics underrated? 22:50 Field progression 29:02 Ultra high voltage in treating cancer 39:00 Understanding significance of bioelectrics from 1900s 44:40 Working with Lionel Jaffe 50:27 How Mike entered bioelectrics 54:02 Criticism received by bioelectrics? 57:04 Missing technology to advance bioelectrics 1:00:52 Electrical patterns in cells with age 1:03:12 Image of electrics in organisms AASTHA, LIVE LONGER WORLD: Twitter: https://twitter.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ Airchat: https://www.getairchat.com/aasthajs Michael Levin: https://twitter.com/drmichaellevin Richard Nuccitelli: https://www.linkedin.com/in/nuccitelli/ Episode Show Notes: https://livelongerworld.com/p/rnuccitelli Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8?si=WrQ_iI8ABbG6eibm

Dr. Mikkael Sekeres is the author of the book The Drugs and FDA. He served as the chair of the Oncology Drugs Advisory Committee of the FDA, and was on the jury for the controversial trial of the breast cancer drug Avastin. We discuss: - The history of the FDA, - The trial of Avastin which got FDA approval in 2008 and revoked in 2011 - FDA's funding mechanisms - FDA ties to big pharma - What can be improved about the FDA and the criticisms it receives Episode Show Notes: https://livelongerworld.com/p/msekeres TIMESTAMPS: 0:00 Surprising finding about the FDA 2:38 Why did the FDA get established in 1938? 11:48 1962 turning point in the FDA & Thalidomide 19:57 Kennedy's efficacy act on drugs approval 25:40 FDA's accelerated approval; HIV & AIDS 33:23 Avastin breast cancer drug controversy 41:13 Why was Avastin trial contentious? 45:23 Genentech's argument 50:00 Media reaction 53:21 FDA funded by big pharma 56:39 FDA vs. patient activist groups 59:50 Opioid crisis 1:03:30 Does the FDA go against advisory committee? CONNECT WITH AASTHA, LIVE LONGER WORLD: Twitter: https://twitter.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ Airchat: https://www.getairchat.com/aasthajs DR. MIKKAEL SEKERES LINKS: Website: https://www.mikkaelsekeres.com/ Twitter: https://twitter.com/MikkaelSekeres Book: https://www.amazon.com/Drugs-FDA-Safety-Efficacy-Publics/dp/0262047314 If you enjoyed the episode, please share it and leave a rating. Best, Aastha.

Dr. Jennifer Garrison is a an Assistant professor at the Buck Institute for research on aging where she studies women's reproductive aging. In today's conversation we discussed menopause and it's effect on women's health, hormone replacement therapy, and how increasing the number of quality eggs a woman has at age 40 by just 1% can be a game changer. Episode Show Notes: https://livelongerworld.com/p/jgarrison Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.com/ Find me (Aastha) on Twitter: https://twitter.com/aasthajs DR. JENNIFER GARRISON LINKS: Lab: http://garrisonlab.com/ Donate to her research: https://gcrle.org/ CONNECT WITH AASTHA, LIVE LONGER WORLD: Twitter: https://twitter.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ Airchat: https://www.getairchat.com/aasthajs TIMESTAMPS: 00:00 Intro 1:38 Jennifer Garrison Intro 2:32 Ovarian aging & health risks 5:23 Progression of Ovarian aging 8:49 Menopause and negative health effects 10:34 Hypothalamus & Mind body communication 14:40 Reproductive & Equality Initiatives 18:21 Biological Clock for Reproductive aging 20:20 Tweaking hormonal cues 22:07 Number of eggs vs. Quality of eggs 25:00 Genetics in ovarian aging 26:21 Understanding family history 27:39 Evolutionary benefit to Menopause? 32:33 Hormone Replacement Therapy (HRT) & its benefits 38:28 Narrow window for HRT 40:08 Perimenopause 42:56 Women's health funding 45:14 Average age girls start menstruating is declining 49:10 PCOS 52:42 Athletes and irregular cycles 56:36 Individualized menopause symptoms 1:00:38 Exercise and ovarian aging 1:02:00 Support Jennifer's work Episode Show Notes: https://livelongerworld.com/p/jgarrison POPULAR EPSIODES: - Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA - Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg - Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8 - Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8 - Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo Thanks for watching & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, or signing up as a premium member. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

Dr. Geoffrey West is the author of the bestselling book Scale, the Universal Laws of Life Growth and Death in Organisms, cities and Companies. He is a physicist who got fascinated by the field of aging and longevity and asked the question of why we live as long as we do and no longer. In today's episode, we dive into his research on the scaling laws in biology and longevity. Episode Show Notes: https://livelongerworld.substack.com/p/gwest Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/ Find me (Aastha) on Twitter: https://twitter.com/aasthajs DR. GEOFFREY WEST LINKS: Profile: https://www.santafe.edu/people/profile/geoffrey-west Book: https://amzn.to/3Xtl7wU CONNECT WITH AASTHA, LIVE LONGER WORLD: Newsletter: https://livelongerworld.substack.com/ Twitter: ⁠https://twitter.com/aasthajs Instagram: https://www.instagram.com/aasthajs/ Airchat: https://www.getairchat.com/aasthajs TIMESTAMPS: 1:35 Context on Dr. West's book Scale 9:00 Networks in biology & cities 22:50 Scaling laws in longevity 32:33 Upper limit to human age? 39:08 Quantifying Caloric restriction 41:52 Metabolism & Body temperature 49:05 Scaling laws in age-related damage 56:35 Scaling body sizes across species 1:01:38 Scaling laws in drug dosage (LSD & Elephants) 1:11:06 Drug dosage in children (Tylenol & babies) 1:13:44 Vaccine dosage scaling laws 1:17:51 Sleep & Aging in different organisms 1:31:22 Early stimulation for child development 1:36:35 Fasting, meal frequency & digestive time 1:39:10 Sleep demands with work & physical activity 1:43:40: Scaling laws in cities, companies & universities 2:02:00 Outro POPULAR EPSIODES: Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8 Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8 Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo Thanks for watching & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, or signing up as a premium member. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

All platforms / Episode Transcript: https://livelongerworld.substack.com/p/saustad Dr. Steven Austad is a professor in the Healthy Aging department at the University of Alabama and also scientific director of the American Federation for Aging research. He has a fascinating entry into the world of aging research - it all began with training lions! There are many open questions on the caloric restriction research for enhancing longevity and we dive into that. Further, a lot of Dr. Austad's work focuses on what long-lived animal species can teach us about living longer and healthier lives. His lab works on exotic species, like clams that live more than 500 years, and hydra that don't age at all, in order to discover aging treatments. He also tries to uncover the mysteries around why men and women respond differently to longevity therapeutics. Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/ Find me (Aastha) on Twitter: https://twitter.com/aasthajz DR. STEVEN AUSTAD LINKS: Website: https://www.stevenaustad.com/ Twitter: https://twitter.com/StevenAustad Faculty page: https://www.uab.edu/cas/biology/people/faculty/steven-n-austad CONNECT WITH AASTHA, LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/aasthajz Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/aasthajz/ TIMESTAMPS: 0:00 Training lions 7:15 Learning from Long-lived species 9:55 Bowhead whales live 200 years 12:55 House sparrows & longevity 14:40 Study "successful" animals 18:10 Naked Mole Rats 20:45 What do bowhead whales die from? 26:05 Why do ocean animals live longest? 31:05 Beyond Caloric Restriction 36:00 Intermittent Fasting & Circadian Rhythm 42:40 Caloric Restriction for Healthy people? 46:24 Will coffee shorten your life? 49:43 The Blue Zone Myth 55:50 Young Blood, I can't get you of out my Mind 1:00:26 Hormones & Health (Growth Hormones for longevity?) 1:05:18 Sex differences in longevity Episode Show Notes: https://livelongerworld.substack.com/p/saustad POPULAR EPSIODES: - Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA - Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg - Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8 - Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8 - Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo Thanks for watching & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom2 Dr. Dom D'Agostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine Cognition. This is Part 2 of a 2 part conversation with Dom. He has so much knowledge to share and in this episode we dive into the ketogenic diet for exercise performance, keto for women & children, Dom's diet & supplement routine + more! Hope you enjoy the episode! Part 1 with Dom on Ketogenic diets for Brain Health and Longevity: https://livelongerworld.substack.com/p/dom1 Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/ Find me (Aastha) on Twitter: https://twitter.com/aasthajz SUPPORT LIVE LONGER WORLD: Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld DOM D'AGOSTINO LINKS: KetoNutrition: https://ketonutrition.org/ Website: https://linktr.ee/Domdagostino Twitter: https://twitter.com/DominicDAgosti2 CONNECT WITH AASTHA, LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/aasthajz Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/aasthajz/ TIMESTAMPS: 0:00 Ketogenic diet for muscle performance 0:50 Dom's supplements & modified keto diet 3:20 Keto, NAD+, NMN 7:12 Biomarkers tracked by Dom 9:30 LDL, Triglycerides, Fatty Foods & Keto diet 14:15 Dom's routine & supplements 18:09 Melatonin benefits for anti-cancer & antioxidant 22:37 Ketogenic diet for women 30:55 Ketogenic diet for children 32:48 Genetic aspect to keto diet? 38:32 Metformin for suppressing cancer 46:30 Ketogenic diet & Alzheimer's 54:40 Exercise for mental health 55:53 Keto for exercise performance & bodybuilding 59:32 Endogenous metabolite & psychedelics 1:09:05 Connect with me (Aastha) Episode Show Notes: https://livelongerworld.substack.com/p/dom2 Thanks for watching & if you enjoy the episode, let's spread the message on longevity. If you like the podcast, please leave a review on Apple podcasts. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom1 Dr. Dom D'Agostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine Cognition. This is Part 1 of a 2 part conversation with Dom. He has so much knowledge to share and in this episode we dive into the history of ketogenic diets, keto for brain health and neuroprotective seizures, keto for longevity benefits, weight training, caloric restriction and more. Hope you enjoy the episode! Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/ Find me (Aastha) on Twitter: https://twitter.com/livelongerworld SUPPORT LIVE LONGER WORLD: Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld DOM D'AGOSTINO LINKS: KetoNutrition: https://ketonutrition.org/ Website: https://linktr.ee/Domdagostino Twitter: https://twitter.com/DominicDAgosti2 CONNECT WITH AASTHA, LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ TIMESTAMPS: 0:00 Ketogenic diet is not optimal for everyone 0:56 Dom D'Agostino Intro 1:29 Plant-based ketogenic diet 3:20 Ketogenic diet & brain protection against seizures 16:40 Ketone Esters & Salts 19:29 Does the brain need glucose? 21:37 Intermittent Ketosis & Fasting Mimicking Diet 25:17 Cyclic Ketogenic diet for longevity 28:40 Devices for tracking ketosis 30:30 Ketogenic diet for longevity vs. Caloric restriction 37:50 Keto diet for cancer prevention 41:57 Keto diet, Insulin pathway, and glucose 46:50 Time restricted eating benefits 50:17 Dom vs. Layne Norton on Joe Rogan podcast 51:40 Muscle for longevity (especially for women) 56:10 Support Live Longer World Episode Show Notes: https://livelongerworld.substack.com/p/dom1 Thanks for watching & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/sapple Sam Apple is the author of Ravenous: Otto Warburg, The Nazis, and the Search for the Cancer-Diet Connection. Otto Warburg was a Nobel-Prize winning German scientist during the era of Hitler and the Nazi's and he was the first person to put the metabolic story of cancer on the map. The famous “Warburg Effect” that shows how cancer cells have an increase in glucose uptake even in the presence of oxygen, is named after him. It was a fascinating conversation talking about how the story of cancer research has evolved - how cancer cells eat to the discovery of oncogenes to coming full circle and making the connection between the two, and what the debate still holds in the story. We also talk about how cancer cells take up a lot of glucose, feed on sugar, and the connection between obesity and cancer. I hope you enjoy the conversation! Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/ Find me (Aastha) on Twitter: https://twitter.com/livelongerworld SUPPORT LIVE LONGER WORLD: Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld SAM APPLE LINKS: Ravenous book: https://amzn.to/3yT9qpd Website: http://www.samapple.com/ Twitter: https://twitter.com/Sam_Apple1 CONNECT WITH AASTHA, LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ TIMESTAMPS: 0:00 Cancer as a disease of modern societies 1:27 Otto Warburg & the Cancer-Metabolic Connection 2:27 Warburg's research on respiration 4:02 Why was cancer skyrocketing in Western societies? 9:17 Warburg Effect: Warburg's research on cancer cells 15:00 Why do cancer cells take up so much glucose? 17:44 Cancer-Diet Connection 21:44 Cancer, Ketogenic diets & Fasting 23:43 Hibernation of the metabolic story of cancer 27:20 Hitler's connection with cancer 30:07 Warburg's arrogance 31:51 Why does cancer need glucose? 38:46 Warburg's stigma: connecting with Nazi's 40:51 Is insulin responsible for cancer? 48:00 Science is not immune from politics 50:24 Prostate cancer & obesity 52:13 Pendulum swing in cancer research 54:40 Mitochondria & Cancer Connection 57:07 Nazi's fixation on cancer Episode Show Notes: https://livelongerworld.substack.com/p/sapple Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev Dr. Vadim Gladyshev is a professor at Harvard Medical school and a Director of redox medicine at Brigham and Women's hospital, where he runs his own lab. We had a brilliant discussion which started off by talking about his work on selenium. Selenium is found is Brazil nuts and we discussed its connection to aging and cancer prevention, and also some of the harmful effects it can have. Dr. Gladyshev calls it the good, the bad, the ugly nature of selenium. Then, we discussed a fair bit on his theory of aging before and after development. Most people believe that the germline which is the reproductive cells do not age, but his lab's work has shown how the germline does in fact age. On this point, his lab also has interesting results on how rapamycin during development extended lifespan in mice. It's important to understand the basic science and understand more on the aging process in order to crack it. Dr. Gladyshev shares his views on this too and his research is certainly a step towards cracking the aging code. I hope you enjoy the conversation! Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworldOne-Time support: https://www.paypal.com/paypalme/livelongerworld Find me on Twitter: https://twitter.com/livelongerworld VADIM GLADYSHEV LINKS: Website: https://gladyshevlab.bwh.harvard.edu/2022 Rapamycin During Development extends Lifespan: https://www.biorxiv.org/content/10.1101/2022.02.18.481092v1 LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS: 0:00 Vadim Gladyshev Intro 1:28 Live Longer World 2:17 Selenium's dual role in aging (the good, the bad, the ugly) 11:27 Antagonistic Pleiotropy 13:53 Selenium & Cancer 15:58 Selenium Dosage (don't get too much!) 18:30 Reactive Oxygen Species, Antioxidants & Aging 22:30 Fundamental basis of Aging 24:09 Aging is damage 29:20 Single cell Epigenetic Clocks 34:22 Aging in the Womb 42:16 Parent's lifestyle for aging in embryo 44:14 Rapamycin during development 49:06 Other compounds 51:53 Slowing Aging vs. Rejuvenation 56:08 New projects being worked on 57:17 Confidence level in extending lifespan within 30 years 59:17 Support Live Longer World Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 Thanks for watching & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

Dr. Ethan Weiss is a cardiologist and his special interests include preventive cardiology, genetics of coronary disease, risk assessment, and heart disease in the young. In today's conversation we spoke about misconceptions people have about heart disease, genetic factors involved in heart disease, how to understand cholesterol and triglycerides in the context of heart disease, ketogenic diets for preventative cardiology and so much more. If you want to understand how to think about your risk assessment for cardiovascular disease and how to prevent it, this conversation is for you. All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/eweiss Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld ETHAN WEISS LINKS: Website: https://profiles.ucsf.edu/ethan.weiss Twitter: https://twitter.com/ethanjweiss LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS: 0:00 Welcome to Live Longer World 0:44 Misconceptions of heart disease / young people with heart disease 4:01 Predictors of heart disease 6:59 LDL vs HDL; Triglycerides 12:51 Small-dense LDL vs. Large fluffy LDL 16:09 Dietary Carbohydrates & heart disease risk 25:50 Inflammation & Cardiovascular risk 26:43 Lipoproteins, ApoB, Lp(a) 31:31 Statins, PCSK9 inhibitors 32:45 ApoB as gold standard risk marker 36:50 Triglycerides & Insulin resistance 40:00 Saturated Fat 42:42 Variation in Cholesterol measurement 46:03 Body composition as marker for heart disease risk 51:23 Ketogenic diets & heart health 56:43 Keyto breath sensor 1:01:46 Stress & heart disease 1:04:44 Growth hormone & heart disease 1:07:46 On the shortness of life 1:10:52 Support & Connect with Live Longer World Episode Show Notes: https://livelongerworld.substack.com/p/eweiss Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 Thanks for listening & if you enjoy the episode, let's spread the message on longevity. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

Dr. Michael Levin is an American developmental and synthetic biologist at Tufts University where he heads his own lab. He also directs the Tufts Center for Regenerative and Developmental Biology. His groundbreaking research focuses on bioelectrical signals that dictate the collective intelligence of cells and direct it to form tissues and organs. His work on bioelectric signals has important applications for how we understand cancer, regenerative medicine and even aging. In fact, he is collaborating with David Sinclair to see how his work can be applied to reverse aging. Michael Levin's work is fascinating and will surely leave you thinking. I hope you enjoy the conversation! All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/mlevin Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld MICHAEL LEVIN LINKS: Website: https://ase.tufts.edu/biology/labs/levin/ Twitter: https://twitter.com/drmichaellevin LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/ Live Longer World Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS: 0:40 How do cells decide what to build? 10:05 DNA is insufficient for dictating collective intelligence of cells 19:00 Anatomical Complier (End game) 22:24 History of Cellular Collective Intelligence & Ala Turing 26:30 Regenerative Medicine & Morphoceuticals 38:05 Cells forming new anatomies 44:53 Cancer as a morphogenetic problem 55:16 David Sinclair, Bioelectrics to reverse aging 57:44 Synthetic Wombs & Artificial Life 59:41 Support Live Longer World! Episode Show Notes: https://livelongerworld.substack.com/p/mlevin Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 If you enjoy my work and wish to support it, consider sharing it with a friend or two and leaving a review on Apple podcasts. And if you are further inclined to show love and support, you can donate on Patreon: patreon.com/livelongerworld Thanks for watching & if you enjoy the episode, let's spread the message on longevity. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

Dr. Richard Miller runs one of the labs for the Interventions Testing Program or the ITP, which is largely considered the gold standard for testing longevity drugs. This was one of the best conversations I've had on longevity supplements that affect lifespan and those that might me subject to mere hype. Dr. Miller is rigorous in his approach and states the data clearly. He also has opinions on lifespan vs. healthspan that are unique from those of most others and worth paying attention to. I genuinely walked away having learned so much from this conversation and feeling more awakened, and I hope it is useful to you too in parsing the data out there on longevity supplements. In today's episode, you will learn: - The 4 winning drugs that increase lifespan in mice as tested by the ITP: Rapamycin, Acarbose, 17-alpha estradiol, Canagliflozin - 3 other drugs that produce small lifespan benefits: NDGA, Glycine, Captopril - Drug combinations: Rapamycin + Acarbose, Rapamycin + Metformin - Drugs that show no lifespan increase in mice in the ITP: Resveratrol, Nicotinamide-Riboside (NR), Fisetin, Curcumin, MCT Oil, Green tea extract, Fish Oil + more - Richard's thoughts on lifespan vs. healthspan All platforms / Episode Show Notes / Timestamps: https://livelongerworld.substack.com/p/rmiller Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Summarized Show Notes: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld RICHARD MILLER LINKS: Website: http://www.richmillerlab.com/ Photography: https://richardmiller.zenfolio.com/ Interventions Testing Program: https://www.nia.nih.gov/research/dab/interventions-testing-program-itp LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS: 0:55 Richard Miller Intro 1:51 Richard Miller Wildlife photography 3:30 ITP - the gold standard for testing longevity drugs & winning drugs 10:51 Rapamycin, Rapamycin + Acarbose 18:48 Rapamycin + Acarbose Dosing Schedule 20:15 Combination of drugs, Rapamycin + Metformin 21:56 17-Alpha Estradiol 25:45 Canagaflozin 31:34 Does Richard take the 4 winning drugs? 32:46 3 Drugs that have small lifespan effects & promising 36:30 GPLD-1 & shared mechanisms in longevity drugs 44:04 Resveratrol in ITP 46:27 NR, NMN 52:34 Curcumin, Green Tea Extract, MCT Oil 54:54 Fisetin & Senolytics 56:12 Why most published research findings are false 1:00:03 Healthspan biomarkers at the ITP 1:02:38 Can you have healthspan without lifespan? 1:07:37 Fish Oil, Spermidine, Sulforophane 1:12:13 Unpublished data Richard is excited about 1:17:47 Flying Pigs & Aubrey De Grey 1:20:00 Exponential rise in aging research Episode Show Notes: https://livelongerworld.substack.com/p/rmiller Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can leave a review on Apple podcasts, subscribe and share the podcast. Aging is universal. Let's unite in this fight.

Yuri Deigin is the founder and CEO of YouthBio Therapeutics which is a company that is working on Epigenetic reprogramming or using the Yamanka factors to achieve partial reprogramming. Epigenetic reprogramming has been in the news lately because of several companies being started in the space, with some notable ones being Altos Labs funded by Jeff Bezos and NewLimit founded by Brian Armstrong, CEO of Coinbase. If you're not familiar with this trending, hyped (rightly so this time - it is pretty amazing!) research on Epigenetic reprogramming and Yamanaka factors to turn cells back to a younger state, we dive into it in today's episode! As a last point to Yuri's introduction, because I'd be remiss if I didn't mention it, you may have heard of his name recently because he was in fact one of the first people to talk about the COVID lab leak theory and wrote extensively on it. This speaks to his scientific mindset and desire to uncover the truth. In today's episode, you will learn: - The Strong Epigenetic Theory of Aging, as coined by Yuri (He calls David Sinclair's theory The Weak Epigenetic Theory of Aging) - Epigenetic Reprogramming using Yamanaka factors to turn the cell into a younger state - What is it and what are the open questions in the field - What are the cancer risks associated with it - Why Yuri believes in Cryonics - Why Yuri got interested in uncovering the COVID-19 Lab Leak theory - Pharma in Russia If you are a premium subscriber, you can also read the summarized notes of these learnings in the show notes. All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/ydeigin Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld YURI DEIGIN LINKS: Twitter: https://twitter.com/ydeigin LinkedIn: https://www.linkedin.com/in/yurideigin/ Medium: https://yurideigin.medium.com/ YouthBio Therapeutics: https://youthbiotx.com/ LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS: 00:00 "We're not crazy" 0:37 100% life extension & translation to humans 4:28 Aging is potentially an engineering problem 12:45 Strong Epigenetic Theory of Aging 19:26 Epigenetic Reprogramming 29:00 Risk of Cancer with Epigenetic reprogramming 33:00 Rejuvenation without cancer risk? 38:30 Why Cryonics Makes Sense 48:00 COVID Lab Leak Theory 53:45 Pharma in Russia 58:40 Optimism in Longevity 1:00:50 Aging is Universal. Let's Unite in this Fight Episode Show Notes: https://livelongerworld.substack.com/p/ydeigin Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can leave a review on Apple podcasts, subscribe and share the podcast. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

Dr. Peter Adams, Professor at Sanford Burnham Prebys Medical Discovery Institute, is an expert in the biology of aging and cancer. The Peter Adams Lab is focused on the Epigenetics of Cancer & Aging and their goal is to contribute to development of epigenetic-based interventions that promote healthy aging and suppression of disease, including cancer. You will hear about some of these contributions in this conversation. In today's episode, you will learn: Cellular Senescence and it's dual role in protecting against cancer but also causing tissue aging The role of senolytic drugs to protect against age-associated cellular senesence The connection between the mitochondria and cellular senescence The Developmental theory of aging (Aging begins in the womb!) If you are a premium subscriber, you can also read the summarized notes of these learnings in the show notes. All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/padams Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld PETER ADAMS LINKS: Lab Website & Bio: http://www.padamslab.org/pages/members.html Peter Adams Twitter: https://twitter.com/AdamsBioAging Peter's Recent Publications: https://www.sbpdiscovery.org/our-scientists/peter-d-adams-phd LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS & EPISODE SHOW NOTES: https://livelongerworld.substack.com/p/padams Thanks for listening & if you enjoy the episode, let's spread the message on longevity. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

My guest today is Andy Lee who is the Chief Operating Officer at Vincere Biosciences. Vincere is working to stop Parkinson's disease by creating small molecules or drugs that target mitochondrial dysfunction. There is increasing evidence that a dysfunctional mitochondria can lead to the onset of Parkinson's disease. In today's conversation, we discussed the science behind a dysfunctional mitochondria and mitophagy, the relationship between the mitochondria and Parkinson's disease, and whether certain mitochondria boosting supplements like Urolithin A and Coq10 that delay the onset of Parkinson's. We also discussed the biological simulation and computational biology platform used by Vincere - they use AI systems that can be used to screen drugs & targets and simulate cell environments. Finally, we spoke about the challenges with running a biotech company. Andy comes from a background in technology and computer science background and he combined it with biology to create Vincere Biosciences. All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/alee Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld ANDY LEE / VINCERE BIO LINKS: Vincere Website: https://vincerebio.com/ Andy Lee Twitter: https://twitter.com/andy_d_lee LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon page: https://www.patreon.com/livelongerworld Podcast All Platforms: https://anchor.fm/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://apple.co/3eZAoAp Spotify: https://spoti.fi/3eZB6O5 Google Podcasts: https://bit.ly/3HN0keG Premium Subscriber Benefits: https://www.livelongerworld.com/premium TIMESTAMPS: 0:00 Live Longer World Intro 0:34 Andy Lee & Vincere Bio Intro 1:55 Vincere & the connection between mitochondria & Parkinson's 7:39 Mitophagy & Parkinson's disease 16:29 Role of USP30 in Mitochondria & Parkinson's 22:26 Vincere small molecules testing 25:18 Other pathways affected during Parkinson's 30:53 Computation Biology Platform used by Vincere 36:50 Urolithin A & Coq10 to help with Parkinson's 39:45 Biomarkers for Mitophagy 42:46 Too much mitophagy? 44:50 Challenges running a biotech company 48:19 Path forward for Vincere 49:36 Support, share and follow Live Longer World! Want Summarized Notes on Key Points Discussed in the Podcast? Gain access by signing up as a premium subscriber. Your contribution supports my work and the advancement of longevity science! Key points summarized in the show notes for premium subscribers include: 1. The connection between Mitochondrial quality control & Parkinson's disease 2. Mitophagy and the science behind targeting the mitochondria 3. Overview of the Biological Simulation Platform used by Vincere Bio 4. Can compounds like Urolithin A & Coq10 that target the mitochondria delay Parkinson's 5. Challenges with running a Biotech Co. Learn more on Premium Subscriber Benefits: https://www.livelongerworld.com/premium Ep. Show notes: https://livelongerworld.substack.com/p/alee

My guest today is Dr. Bjorn Schumacher whose work focuses on the central role of DNA damage in the aging process. We discussed DNA damage accumulation with age, how DNA repair mechanisms play a role, how DNA damage in the reproductive cells can tell us a lot about aging, human fertility and reproductive capacity. We also discussed the role of p53 in cancer suppression, a new biological age clock being developed in his lab and how we should protect our skin from aging and thereby control DNA damage. A lot of us have heard about the link between DNA damage and aging and this conversation really dives into it. All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/bschumacher Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld DR. BJORN SCHUMACHER LINKS: Lab Website: https://www.cecad.uni-koeln.de/research/principal-investigators/prof-dr-bjoern-schumacher Twitter: https://twitter.com/schumacherbj Author of the book: The Mysteries of Human Aging: Surprising Insights from a Science That's Still Young: https://amzn.to/3LyR3JU LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon page: https://www.patreon.com/livelongerworld Podcast All Platforms: https://anchor.fm/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://apple.co/3eZAoAp Spotify: https://spoti.fi/3eZB6O5 Google Podcasts: https://bit.ly/3HN0keG Premium Subscriber Benefits: https://www.livelongerworld.com/premium TIMESTAMPS: 0:00 Live Longer World Intro 0:30 Bjorn Schumacher Intro 1:22 DNA Damage as Central to the Aging process 3:37 DNA repair with age 8:39 Premature aging; 2 distinct forms of DNA damage 14:15 How does an aging human survive with DNA damage & tamp down cancer? 18:20 Stress to reproductive cells builds up immunity in the body 24:41 Female reproduction, Menopause & DNA repair 27:46 p53 and it's role in DNA repair 35:13 BiT Clock: New Biological Age Clock 43:59 Skin Aging and DNA damage 48:06 Stress in the intestine / gut can alter the chromosome 53:00 Germ cells are immortal For links to DR. Bjorn Schumacher research discussed: https://livelongerworld.substack.com/p/bschumacher Want Summarized Notes on Key Points Discussed in the Podcast? Gain access by signing up as a premium subscriber. Your contribution supports my work the advancement of longevity science! Key points summarized in the show notes for premium subscribers include: The central role of DNA damage in the aging process What happens to our body's DNA repair mechanism with age? DNA Damage in the germ cells (reproductive cells) promotes stress resistance in the body The role of p53 in suppressing cancer and in the DNA repair process Learn more: https://www.livelongerworld.com/premium Thanks for listeni

My guest today is Dr. David Gems who runs the C. Elegans Aging lab at the University College London. We had a fascinating discussion talking about emerging paradigms in the theories of aging. We discussed the hyperfunction theory or the programmatic theory of aging which gives a better integrated understanding of the different theories of aging that have been presented such as damage accumulation, evolutionary, antagonistic pleiotropy. It has been assumed that molecular damage is always the cause of aging, but the programmatic theory of aging shows that that might not be the case. We also discussed his critique of the hallmarks of aging and how there should be a better paradigm for the aging field. Lastly, we also discussed how research from his lab on C. Elegans might explain some of the conflict around whether sirtuins affect lifespan and how C. Elegans also show versions of this programmatic theory of aging, which can give us a better understanding of how to study aging. Note: There is a point in the conversation (40:41) where David pulls up some slides to better explain the Multifactorial Model of Aging. So if you are listening to the audio version, you might want to refer to YouTube or the show notes. All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/dgems Support on Patreon: https://www.patreon.com/livelongerworld Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast DR. DAVID GEMS LINKS: Lab Website: https://www.ucl.ac.uk/~ucbtdag/DGHistory.html LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon page: https://www.patreon.com/livelongerworld Podcast All Platforms: https://anchor.fm/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://apple.co/3eZAoAp Spotify: https://spoti.fi/3eZB6O5 Google Podcasts: https://bit.ly/3HN0keG Premium Subscriber Benefits: https://www.livelongerworld.com/premium TIMESTAMPS: 00:00 Live Longer World 00:25 David Gems Intro 1:47 History of the theories of aging 12:23 Hyperfunction / Programmatic Theory of Aging 24:57 Programmatic Theory of Aging in C. Elegans 36:59 Hyperfunction theory of Aging in Humans 40:41 Multifactorial Model of Aging 50:32 Mutation in C. Elegans affecting Sirtuin research? 59:57 Sirtuin research in humans & conflicting sirtuin research 1:04:44 Metformin affects the gut microbiome 1:07:41 Critique of the Hallmarks of Aging 1:16:12 Disruption in Early Life could lead to Aging related diseases 1:24:23 Support, share, and follow Live Longer World To find links to David Gems research discussed, please refer to the show notes: https://livelongerworld.substack.com/p/dgems Thanks for listening & if you enjoy the episode, please leave a review on Apple podcasts, support on Patreon, subscribe & share! Stay in good health - Aastha.

My guest today is Dr. Bruce Ames who has received several awards and accolades for developing the Ames test which is used to detect carcinogens in commercial products. He showed how there were carcinogens in products such as hair dyes and children's pajamas! Later, Dr. Bruce Ames turned to studying micronutrients and how deficiency of important vitamins and minerals leads to accelerated aging. He came up with the Micronutrient triage theory, which says that when nutrient intake is insufficient, the body has a rationing mechanism and favors proteins needed for immediate survival at the expense of protection against future damage. Dr. Bruce Ames is 93 years old and says that he is still exercising and eating healthy greens cooked by his lovely Italian wife! However, he says his cognitive capacity has slowed down (this is why we need rejuvenation therapies, even for the brain: listen to my episode with Dr. Jean Hebert who talks about Brain Aging and his strategy to reverse aging through replacement of the body parts: https://youtu.be/oerGUepWsH8). I am grateful that I had a chance to converse with him on Vitamin D, longevity micronutrients, how micronutrient deficiency can lead to accelerated aging, his take on the science behind reversing aging, and his advice to younger people. This is a shorter episode and I hope you learn more about the importance of micronutrients! All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/bames RELATED WRITING: My newsletter post explaining the Micronutrient Triage theory: https://livelongerworld.substack.com/p/bruceames My post on Longevity Foods (Nutrition Doesn't have to be so complicated): https://livelongerworld.substack.com/p/longevityfoods Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Find me on Twitter: https://twitter.com/livelongerworld Support on Patreon: https://www.patreon.com/livelongerworld DR. BRUCE AMES LINKS: Website: http://www.bruceames.org/ LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon page: https://www.patreon.com/livelongerworld Podcast All Platforms: https://anchor.fm/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://apple.co/3eZAoAp Spotify: https://spoti.fi/3eZB6O5 Google Podcasts: https://bit.ly/3HN0keG Premium Subscriber Benefits: https://www.livelongerworld.com/premium TIMESTAMPS: 00:00 Live Longer World 00:36 Bruce Ames Intro 1:50 Micronutrient triage theory 5:40 Micronutrient deficiencies & age acceleration 9:10 Vitamin D for healthy aging 12:26 CHORI Bar 14:46 Measuring micronutrients (blood finger-prick) 16:55 Bruce Ames diet 18:19 Asthma caused by obesity / bad diet improved by CHORI bar 21:21 Dr. Ames lifestyle over the years 22:47 Importance of zinc 24:15 Nutrition is complicated 24:44 Dr. Ames last words & advice for young scientists Thanks for listening & if you enjoy the episode, please like, leave a review on Apple podcasts, subscribe & share! Stay in good health - Aastha.

My guest today is Dr. Brian Kennedy who is the Director for the Center of Healthy Aging at the National University of Singapore. He is also the former President and CEO of the Buck Institute of Research on Aging. Dr. Kennedy is well-known in the field of longevity & beyond and has been involved in critical aging research. Dr. Kennedy's lab is working on different small molecules and natural products that could boost longevity. In today's discussion, we spoke about the network concept of the hallmarks of aging, the longevity effects of natural products like Alpha-Ketoglutarate (AKG), Spermidine and Urolithin A, and why combining some of these supplements might not be prudent. We also spoke about comparing the different biomarkers of aging, what we can learn from the longevity of bats, and why basic science is important. All platforms / Episode Show Notes + Timestamps: https://livelongerworld.substack.com/p/bkennedy Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Support on Patreon: https://www.patreon.com/livelongerworld DR. BRIAN KENNEDY LINKS: Lab Website: https://medicine.nus.edu.sg/bch/faculty/brian-kennedy/ Twitter: https://twitter.com/BKennedy_aging LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon page: https://www.patreon.com/livelongerworld Podcast All Platforms: https://anchor.fm/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://apple.co/3eZAoAp Spotify: https://spoti.fi/3eZB6O5 Google Podcasts: https://bit.ly/3HN0keG Premium Subscriber Benefits: https://www.livelongerworld.com/premium DR. BRIAN KENNEDY RESEARCH DISCUSSED: 2020 Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice: https://pubmed.ncbi.nlm.nih.gov/32877690/ 2020 Aging Biomarkers: From Functional Tests to Multi-Omics Approaches: https://pubmed.ncbi.nlm.nih.gov/32084299/ 2021 The Autophagy Inducer Spermidine Protects Against Metabolic Dysfunction During Overnutrition: https://pubmed.ncbi.nlm.nih.gov/34060628/ 2021 Association between housing type and accelerated biological aging in different sexes: moderating effects of health behaviors: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436907/ 2020 The World Goes Bats: Living & Tolerating Viruses: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341951/ 2021 Yeast as a model organism for aging research: https://www.sciencedirect.com/science/article/pii/B9780128159620000081 Thanks for watching & if you enjoy the episode, please like, comment, subscribe & share! Stay in good health - Aastha.

My guest today is Dr. Collin Ewald who is a professor at the Health Sciences department at ETH Zurich. His lab focuses on understanding the extracellular matrix (ECM) and how it changes with age. Collin explains the role of the ECM in tissue repair, muscle strength, and overall longevity. In fact, Collin's lab is also working on establishing the ECM as a biomarker for health and disease risk. So, studying the ECM can indeed tell us a lot about the aging process and ways to intervene. Think of the ECM as the environment that surrounds the cell or the proteins secreted from the cell. It holds our organs and tissues in place. You've probably heard of collagen protein - it is largely found in the ECM. Why is the ECM relevant for longevity research? Turns out, the ECM changes with age. In fact, each cell has a unique ECM and cancer cells can be detected by their ECM composition type! There is also a connection between the ECM and the muscle, and damage to collagen with age results in weakening of our muscles. We discuss changes in collagen with age, how sugar impacts collagen, cancer cells & ECM, the overexpression of certain collagens with age, changes in collagen causing muscle impairment with age, and longevity interventions his lab is studying to repair the impairment damage. (This podcast can be a little technical, especially in the beginning, so I'd recommend referring to the show notes for better understanding. The video version of the podcast also contains some explanations on the video slide itself.) All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/cewald Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Support on Patreon: https://www.patreon.com/livelongerworld DR. COLLIN EWALD LINKS: Lab Website: https://www.ewaldlab.com/ Twitter: https://twitter.com/CollinEwald LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon page: https://www.patreon.com/livelongerworld Podcast All Platforms: https://anchor.fm/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://apple.co/3eZAoAp Spotify: https://spoti.fi/3eZB6O5 Google Podcasts: https://bit.ly/3HN0keG Premium Subscriber Benefits: https://www.livelongerworld.com/premium TIMESTAMPS: Episode Page: https://livelongerworld.substack.com/p/cewald YouTube: https://youtu.be/r1Y5wGSqKWA DR. COLLIN EWALD RESEARCH: The Matrisome during Aging and Longevity: https://www.karger.com/Article/FullText/504295 Collagen overexpression increasing lifespan: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352135/ Youthful and age‐related matreotypes predict drugs promoting longevity: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441316/ Doubling life near death: https://elifesciences.org/digests/71335/doubling-life-near-death Thanks for watching & if you enjoy the episode, please like, comment, leave a review, subscribe & share! Stay in good health - Aastha.

My guests in today's episode are Dr. Irina and Michael Conboy of the Department of Bioengineering at the University of California Berkeley. Their groundbreaking research focuses on tissue rejuvenation via plasma dilution and heterochronic parabiosis, where the Conboys took a young mouse and an older mouse and sutured them together, such that the animals shared blood and environment. The old mice became rejuvenated & younger. They've also pioneered a process called the Neutral Blood Exchange or Therapeutic Blood Exchange, through which dilution of old blood plasma can lead to true rejuvenation in the brain & other tissues of mice to a younger state!! Further, we touch upon Irina's work showing how decreased Oxytocin levels with age contributes to poor muscle function. Their research is incredibly exciting and we discuss all about it in today's episode. Episode Show Notes: https://livelongerworld.substack.com/p/rejuvenation-via-plasma-dilution Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast DR. CONBOY LINKS: Berkeley Lab: https://conboylab.berkeley.edu/ 2021 Paper Plasma Dilution Improves Cognition and attenuates neuroinflammation in old mice: https://pubmed.ncbi.nlm.nih.gov/33191466/ 2020 Paper Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288913/ 2014 Paper Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration: https://www.nature.com/articles/ncomms5082 LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Podcast All Platforms: https://anchor.fm/livelongerworld Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://apple.co/3eZAoAp Spotify: https://spoti.fi/3eZB6O5 Google Podcasts: https://bit.ly/3HN0keG TIMESTAMPS: 00:00 Live Longer World Intro 00:35 Irina & Michael Conboy Intro 1:08 Aging is slowdown in our repair machinery 2:55 Naked Mole Rats not extreme model for longevity 5:37 Heterochronic Parabiosis 16:00 Young Blood to Old Blood Exchange 19:19 Rejuvenation via Neutral Blood Exchange (NBE) 22:56 Old Blood Degenerates Young Mice 25:29 Rejuvenation Effects on Brain, Liver, Muscle through NBE 27:16 How long do effects of NBE last? 30:15 How is NBE working mechanistically? 2 waves of rejuvenation 33:38 Inhibiting TGF-beta & Increasing Oxytocin is rejuvenative 38:12 NBE vs. Senolytics 40:53 Unanswered Questions on NBE 43:13 Oxytocin & Muscle Functioning; Notch Signaling 48:12 Chickens & Ravens as Pets! Thanks for listening & if you enjoy the episode, please like, subscribe & share! Stay in good health - Aastha.

Dr. Nir Barzilai is well-known in the field of longevity and beyond and is the director and chair of several institutes focused on Aging research. Just to name a few, he is the director of the Institute for Aging Research at the Albert Einstein College of Medicine and of the National Institutes of Health's (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. Dr. Barzilai's research interests are in the biology and genetics of aging, so he has done extensive work studying centenarians and supercentenarians some of which he discusses in today's episode and also in his book Age Later. He is currently leading an international effort to approve drugs that can target aging. Targeting Aging with METformin (TAME) is a specific study designed to prove the concept that multi-morbidities of aging can be delayed by metformin, working with the FDA to approve this approach which will serve as a template for future efforts to delay aging and its diseases in humans. In today's episode, we discuss centenarian longevity genes, what makes centenarians live so long and the role of growth hormones in longevity. We also dive into metformin's healthspan benefits for longevity, metformin & COVID, if metformin blunts muscle mass and causes hypoglycemia, and metformin dosage. Episode Show Notes + Timestamps: https://livelongerworld.substack.com/p/snbarzilai FOLLOW NIR BARZILAI: Profile: https://einsteinmed.edu/faculty/484/nir-barzilai/ Twitter: https://twitter.com/NirBarzilaiMD Book: https://us.macmillan.com/books/9781250230867 FOLLOW LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Podcast All Platforms: https://anchor.fm/livelongerworld Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://podcasts.apple.com/us/podcast/live-longer-world/id1588806541 Spotify: https://open.spotify.com/show/2Zc65BZb02msGuF9ujBThC

The final 2021 episode of the Live Longer World podcast is a rather special one. I've compiled some of the best & most informative parts of each of my previous episodes and highlighted them in this finale episode. Think of it as a tour showcasing some of the work being done in the field of longevity. Some topics included in the clips are Inflammaging, SystemsAge Clock, Reprogramming, Atherosclerosis, Brain Aging and more. And if a particular topic or clip captures your attention, you can of course go and watch the entire podcast episode. Hope you enjoy it and wishing everyone a happy & healthy holiday season! Episode Show Notes: https://livelongerworld.substack.com/p/2021 Find the previous podcast episodes: https://www.livelongerworld.com/podcast 2021 Live Longer World podcast episodes: #01: Reason, founder & CEO of Repair Biotechnologies #02: Dr. Jean Hebert on Tissue Replacement in the Brain #03: Carolina Oliveira, the founder & CEO of OneSkin #04: Dave Gobel, founder & CEO of Methuselah Foundation #05: Dr. Matt Kaeberlein on Aging Interventions, Rapamycin, mTOR #06: Dr. Morgan Levine on Epigenetic Clocks, SystemsAge Clock FOLLOW LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Podcast All Platforms: https://anchor.fm/livelongerworld Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://podcasts.apple.com/us/podcast/live-longer-world/id1588806541 Spotify: https://open.spotify.com/show/2Zc65BZb02msGuF9ujBThC

Dr. Morgan Levine is an Assistant Professor of Pathology and Epidemiology at the Yale School of Medicine. Morgan runs the lab for Aging in Living Systems at Yale. Her labs works on Epigenetic Clocks, Epigenetic reprogramming, cellular aging trajectories, and in trying to understand the causes of Alzheimer's disease. I can't even begin to tell you how much I learned in today's conversation! We extensively discussed Morgan's work on developing a new Epigenetic clock called the SystemsAge clock, which is very cool and can test the biological age of different organs & systems in your body. We also spoke of different features of these clocks, interventions tested, what we know so far on reversing your biological age, some of the limitations of the clocks, why she is so excited about epigenetic reprogramming, and some of her work around Alzheimer's disease. Most people are interested in knowing their biological age and epigenetic clocks are a way to test it. So I'm sure you will find this conversation on epigenetic clocks fascinating and walk away understanding them much better! I hope you enjoy my conversation with Dr. Morgan Levine. Show notes + Timestamps: https://livelongerworld.substack.com/p/mlevine FOLLOW DR. MORGAN LEVINE: Morgan's Lab: https://www.morganlevinelab.com/ Twitter: https://twitter.com/DrMorganLevine FOLLOW LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Newsletter: https://livelongerworld.substack.com/ Twitter: https://twitter.com/livelongerworld Patreon: https://www.patreon.com/livelongerworld Instagram: https://www.instagram.com/longevityfuture Apple Podcasts: https://podcasts.apple.com/us/podcast/live-longer-world/id1588806541 Spotify: https://open.spotify.com/show/2Zc65BZb02msGuF9ujBThC

Dr. Matt Kaeberlein is a Professor of Pathology, Adjunct Professor of Genome Sciences, and Adjunct Professor of Oral Health Sciences at the University of Washington. His research interests are focused on basic mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. Matt has been around the field of aging for a long time and knows more about the work in the aging field than perhaps anyone else. This was a comprehensive conversation where we spoke about how Matt thinks of aging from a functional perspective, caloric restriction and aging, whether NAD+ precursors are effective in slowing aging, the role of sirtuins. We discuss quite a bit on rapamycin and how it's shown to be effective in improving the health of mice. Matt is very excited about the potential benefits of Rapamycin in reversing aging and he got me excited too. Matt is also working on the Dog Aging project and in trying to understand aging in dogs. Finally, we end the conversation by talking a bit on what good scientific practices should look like. Matt approaches his work with an unbiased lens and that's very respectable. Matt has a brilliant mind! I had such a blast talking to Matt and I hope you enjoy the conversation as much as I did! Timestamps in the YouTube version of this podcast: ttps://www.youtube.com/channel/UCcoEB1MXhkI_CFwsHRtPXUg FOLLOW LIVE LONGER WORLD: Twitter: https://twitter.com/livelongerworld Website: https://www.livelongerworld.com/ YouTube: https://www.youtube.com/channel/UCcoEB1MXhkI_CFwsHRtPXUg Patreon: https://www.patreon.com/livelongerworld Apple Podcasts: https://podcasts.apple.com/us/podcast/live-longer-world/id1588806541 Spotify: https://open.spotify.com/show/2Zc65BZb02msGuF9ujBThC Instagram: https://www.instagram.com/longevityfuture/ Store: https://www.longevitystore.co/ FOLLOW MATT KAEBERLIN: Website: https://kaeberlein.org/ Twitter: https://twitter.com/mkaeberlein Dog Aging Project: https://dogagingproject.org/

My guest today is David Gobel who is the co-founder & CEO of the Methuselah foundation. Methuselah foundation has donated several million dollars for the advancement of longevity research and regenerative medicine. Their goal is to make make 90 the New 50 by 2030. I'm definitely rooting for that! Dave was an entrepreneur before he decided to jump into the field of longevity. In my conversation with him, we discuss how he got excited about longevity research, companies funded by Methuselah including Oisin Biotechnologies, the concept of longevity escape velocity, his work with the super centenarian research foundation, how one can get involved in funding longevity companies and more. I hope you enjoy the episode! TIMESTAMPS: 0:00 Live Longer World Intro 1:30 David Gobel & Methuselah Foundation Intro 2:00 Dave's work at the TSA; Innovation at TSA 10:39 Methuselah Fund, How Dave got interested in Longevity & met Aubrey De Grey 19:14 The current healthcare system does not focus on preventative medicine; Aging is the biggest risk factor for all diseases 20:40 Methuselah Foundation mission - Making 90 the new 50 by 2030 26:56 Companies funded by Methuselah - Turnbio, Epigenetic reprogramming, Organovo 3D Tissue Printing 30: 18 Leucadia Therapeutics & working to erase Alzheimer's disease 37:20 Donating to Longevity 38:24 Investing in Longevity - how to get started 40:20 Vascular Tissue Challenge with NASA 43:05 Longevity Escape Velocity 47:28 Challenges in the Longevity Field (Money comes to winning solutions & ideas!) 51:55 Do we use money or does money use us? 57:00 Ending remarks FOLLOW LIVE LONGER WORLD: Newsletter: https://livelongerworld.substack.com/ Twitter: https://twitter.com/livelongerworld Website: https://www.livelongerworld.com/ Instagram: https://www.instagram.com/longevityfuture/ Apple Podcasts: https://podcasts.apple.com/us/podcast/live-longer-world/id1588806541 Spotify: https://open.spotify.com/show/2Zc65BZb02msGuF9ujBThC Patreon: https://www.patreon.com/livelongerworld Store: https://www.longevitystore.co/ FOLLOW METHUSELAH FOUNDATION: Website: https://www.mfoundation.org/ Twitter: https://twitter.com/mfoundation

Carolina Reis Oliveira is the founder & CEO of OneSkin Technologies. OneSkin is pioneering technologies aimed at extending human healthspan. Their first product is a topical supplement designed to extend your skinspan by improving skin health and skin strength. Their proprietary peptide, OS-01, has been shown to rejuvenate your skin on a molecular level and effectively treat the negative implications of aging. Carolina holds her Ph.D. in Immunology at the Federal University of Minas Gerais in collaboration with the Rutgers University and is an alumnus of IndieBio, the world's leading biotechnology accelerator. In 2016, Carolina relocated to Silicon Valley from Latin America to co-found OneSkin, and to lead the development of the company's disruptive rejuvenation technologies. Carolina is full of energy and I really enjoyed talking to a scientist entrepreneur! 0:00 Live Longer World Intro 1:06: Carolina & OneSkin Intro 2:25 Jokes, Pleasing Indian Mom 4:00 Skin Aging; Cellular Senescence 8:05 Skin Overlooked in Longevity Research; Concentration of Senescent Cells in Skin 11:30 OneSkin Product; OS-1 Peptide 17:35 Does the product work across ethnicities & skin types? 20:55 Results from product; elimination of senescent cells 23:42 Senomorphics (slow down progression of senescent cells) 25:50: Results from studies in C. Elegans 30:31 OneSkin vs. Fistein vs. Retinol 35:21 Recommendation if using Retinol 37:21 Senolytic Drugs vs. OneSkin 40:19 Skin aging from Sun Damage 42:17 Which age to start using OneSkin? 44:47 Human Studies for OS-1 49:08 FDA Approval for drugs 51:00 Future products 53:47 Excitement about Longevity Industry 56:47 Connect with OneSkin 58:17 Connect with Live Longer World FOLLOW LIVE LONGER WORLD: Newsletter: https://livelongerworld.substack.com/ YouTube: https://www.youtube.com/channel/UCcoEB1MXhkI_CFwsHRtPXUg Twitter: https://twitter.com/livelongerworld Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld Apple Podcasts: https://podcasts.apple.com/us/podcast/live-longer-world/id1588806541 Spotify: https://open.spotify.com/show/2Zc65BZb02msGuF9ujBThC Store: https://www.longevitystore.co/ Website: https://www.livelongerworld.com/ FOLLOW ONESKIN: Website: https://www.oneskin.co/ Instagram: https://www.instagram.com/oneskin.co/ LinkedIn: https://www.linkedin.com/company/oneskin/ Twitter: https://twitter.com/OneSkinTech

Jean M. Hébert, PhD, is a Professor of Neuroscience and Genetics at the Albert Einstein College of Medicine in New York. Dr. Hebert was fascinated from a young age by how a single cell forms the whole human body following an innate genetic program and he got excited by how knowledge of this process might be used to improve our biological fates and defeat aging. He is a molecular geneticist by training and obtained his Ph.D. from the University of California, San Francisco, before specializing in the study of how neural stem cells form the brain at Stanford University. His lab is now developing ways to use cell and tissue replacements to repair and rejuvenate the brain. More specifically, the Hébert Lab is engineering tissue that increasingly resembles normal neocortex, the part of our brain that performs our highest cognitive functions, and testing the ability of this tissue to integrate with the host brain. Jean is the author of Replacing Aging. We had an extremely interesting conversation ranging from why Dr. Hebert thinks the other methods to fight aging may not work if the goal is to beat aging, we discuss 3D organs and tissue cell replacement and we also discuss the neocortex and what it takes to replace one and lastly we talk about how plasticity in the brain works. Even if you are not associated with the field of longevity, you'll find this conversation interesting and refreshing. FOLLOW LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Newsletter: https://livelongerworld.substack.com/ YouTube: https://www.youtube.com/channel/UCcoEB1MXhkI_CFwsHRtPXUg Twitter: https://twitter.com/livelongerworld Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld Store: https://www.longevitystore.co/ FOLLOW DR. JEAN HEBERT: Twitter: https://twitter.com/Replacing_Aging Website: https://hebertlab.einsteinmedneuroscience.org/

Reason is the founder and CEO of Repair Biotechnologies. Repair Biotechnologies is a biotech company focused on developing therapies that treat medical conditions arising due to accumulation of excessive cholesterol. They have developed a unique Cholesterol Degrading Platform to reverse the damage that leads to heart disease and atherosclerosis. More than 5 million people die every year due to atherosclerosis and Repair Biotechnologies is trying to solve this problem. Reason is perhaps most well known for his popular blog Fight Aging! where he distills the latest research in aging science. For anyone looking to stay informed on aging & longevity research, I highly recommend you checking it out - it's one of the best resources out there. In today's conversation, we discuss how to think of aging simply, the differences between slowing and reversing aging, NAD+ boosters and their effectiveness, reversing aging using senolytics, how his company is working on a gene therapy to reverse artherosclerosis and cardiovascular disease, problems with Alzheimer's research, working towards aging rejuvenation therapies, how one can get involved in the aging space, and much more. Note: We discuss a fair bit on cellular senescence and senolytic therapies. For those unfamiliar with the concept, cellular senescence is a process in which cells lose their ability to divide but refuse to die. When these senescent cells don't get cleared away, they release harmful substances and damage the cells around them too. It is well known that senescent cells accumulate with age, contributing to inflammation and aging itself. Senolytics is a class of drugs that can selectively clear away these senescent cells and they have shown promise in delaying and preventing age-related diseases. FOLLOW LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Newsletter: https://livelongerworld.substack.com/ YouTube: https://www.youtube.com/channel/UCcoEB1MXhkI_CFwsHRtPXUg Twitter: https://twitter.com/livelongerworld Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld Store: https://www.longevitystore.co/ FOLLOW REASON AND REPAIR BIOTECHNOLOGIES: Fight Aging! Blog: https://www.fightaging.org/ Company Website: https://www.repairbiotechnologies.com/

"Can I really live to be 200? Can I feel like I'm 20 when I'm 70? Can aging be reversed? Hold up, what even is aging? Now I'm curious to know about aging and longevity science!" Well then, you're at the right spot! Hello and welcome to Live Longer World! The science of aging is moving rapidly and making progress at defeating age-related diseases and aging itself. We take you right where the action is happening! Through conversations with scientists, entrepreneurs, investors and other advocates revolutionizing the field of longevity science, we tell you how you can be disease-free, reverse aging, and maximize longevity in the future. To stay informed on what the future of aging and longevity looks like, make sure to subscribe to Live Longer World at Apple podcasts, Spotify, YouTube or wherever you get your podcasts. We look forward to transforming how we age in the future and bring you along on this wonderful journey.