Podcasts about Frailty

This episode was originally released August 3rd for Death Panel patrons. To support the show and help make episodes like this one possible, become a patron at www.patreon.com/deathpanelpod Beatrice, Artie and Phil discuss the Trump administration's proposal to shift the definition of “medical frailty” under Medicaid to explicitly redefine health as your ability to work, and how this change threatens not just the healthcare coverage of countless people, but an impending blow against the Medicaid program and the healthcare system itself. Show links: We're testing out a new Bookshop.org page (still under construction), where you can find books by past guests and book recommendations from the hosts. Find it here: https://bookshop.org/shop/deathpanel Get Health Communism here: https://bookshop.org/a/118130/9781839765179 Outro by Time Wharp: timewharp.bandcamp.com/track/tezeta

Viele ältere Patientinnen und Patienten nehmen zehn oder mehr Medikamente ein. Doch je länger eine Medikation besteht, desto wichtiger wird die Frage, ob sie noch zum aktuellen Gesundheitszustand, zur Funktionalität und zu den Therapiezielen passt. „Man kann in der Altersmedizin keine One-size-fits-all-Empfehlungen geben“, sagt Prof. M. Cristina Polidori.

In this podcast episode, James A. Davis, PharmD, BCOP, and Kelley L. Julian, PharmD, BCOP, discuss evidence-based strategies for managing smoldering and newly diagnosed multiple myeloma, including: Risk stratification and treatment selection for smoldering multiple myeloma Anti-CD38–based regimens for transplant-eligible and transplant-ineligible patients Clinical evidence supporting triplet and quadruplet therapies MRD assessment and response-adapted treatment strategies Frailty, transplant eligibility, and individualized treatment selection Subcutaneous anti-CD38 administration and premedication requirements Pharmacist-led supportive care, toxicity management, dose modification, and patient counseling Get access to all of our new podcasts by subscribing to the Decera Clinical Education Oncology Podcast on Apple Podcasts, YouTube Music, or Spotify. Presenters:James A. Davis, PharmD, BCOP Clinical Pharmacy Specialist, Myeloma/Lymphoma The Medical University of South Carolina, Hollings Cancer Center Affiliate Assistant Professor MUSC College of Pharmacy Charleston, South Carolina Kelley L. Julian, PharmD, BCOP Hematology/BMT Pharmacy Supervisor PGY2 Oncology Pharmacy Residency Program Director Huntsman Cancer Institute, University of Utah Salt Lake City, Utah Link to full program: https://bit.ly/4qaRb7n Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In the August open access episode of Chattering With iCatCare, Yaiza Gómez-Mejías is joined by veterinary nutritionist Marge Chandler to explore the critical concepts of sarcopenia, cachexia, and frailty in older cats. The conversation focuses on shifting our approach to feline geriatrics, moving beyond the simple concept of the "thin old cat" towards proactive clinical management and preserving quality of life.They explore the key clinical distinctions between sarcopenia and cachexia, why measuring frailty is vital for feline well-being, and how concepts like anabolic resistance challenge traditional dietary advice for senior cats. Marge also addresses common hurdles clinicians face when implementing muscle condition scoring and shares practical, high-impact strategies to help slow muscle loss in everyday practice. For further reading material please visit:A non-randomized pilot study to test the feasibility of developing a frailty scale for pet catsSarcopenia, cachexia and frailty in older cats: mechanisms, assessment and therapeutic considerationsHost:Yaiza Gómez-Mejías, LdaVet MANZCVS (Medicine of Cats), RCVS CertAP (Feline Medicine), iCatCare Veterinary Community Co-ordinatorSpeaker:Marjorie Chandler, DVM, MS, MANZCVS, Diplomate DACVIM (Nutrition & Internal Medicine), MRCVS, RCVS Recognized Specialist in Nutrition

As we age, one of the greatest threats to long-term health isn't just disease. It's the gradual loss of strength, muscle mass, and physical function that can ultimately lead to frailty. In this episode of the Rehab Science Podcast, I sit down with Dr. Jeremy Bettle, PhD to discuss why strength training is one of the most powerful tools we have for maintaining independence, preventing injury, and improving quality of life throughout the lifespan. We explore the relationship between strength and healthy aging, the role of exercise in reducing fall risk and osteoporosis, and why rehabilitation often falls short of preparing people to return to the activities they value most. In this episode, we discuss: • What frailty is and why it develops • Why strength is one of the strongest predictors of long-term health and function • The relationship between muscle mass, aging, and independence • How resistance training influences bone health and osteoporosis • Strategies for reducing fall risk • The connection between strength, brain health, and cognitive function • Common shortcomings in traditional rehabilitation • What "return to performance" should really look like after an injury • Practical advice for building and maintaining strength at any age Whether you're recovering from an injury, trying to stay active as you age, or simply looking to improve your long-term health, this episode provides practical insights into why strength should be a lifelong priority. Link for my first podcast with Dr. Bettle: https://open.spotify.com/episode/77Olhy3pnxICBFENDpRnTb?si=d173e3834ad843bc Dr. Bettle's website: https://vitality-collective.com/

Subscribe on Patreon and hear this week's full patron-exclusive episode here: https://www.patreon.com/deathpanelpod/posts/165668581 Beatrice, Artie and Phil discuss the Trump administration's proposal to shift the definition of “medical frailty” under Medicaid to explicitly redefine health as your ability to work, and how this change threatens not just the healthcare coverage of countless people, but an impending blow against the Medicaid program and the healthcare system itself. Runtime 1:28:52 Get Health Communism here: https://bookshop.org/a/118130/9781839765179

Pastor Ken Biggs | AM Aug 2nd, 2026 | Man's Frailty / God's Purpose

Welcome to Day 2915 of Wisdom-Trek. Thank you for joining me. This is Guthrie Chamberlain, Your Guide to Wisdom. Day 2915 – Wisdom Nuggets – Psalm 146:1-10 Daily Wisdom Wisdom-Trek Podcast Script - Day 2915 Welcome to Wisdom-Trek with Gramps! I am Guthrie Chamberlain, and we are on Day 2915 of our Trek. The Purpose of Wisdom-Trek is to create a legacy of wisdom, to seek out discernment and insights, and to boldly grow where few have chosen to grow before. The title for today's Wisdom-Trek is: The Sovereign Creator and the Frailty of Princes – Unveiling the Eternal Helper On our previous podcast, on Day Two Thousand Nine Hundred Thirteen, we reached a momentous milestone in our journey through the Book of Psalms, as we closed out Psalm One Hundred Forty-Five—the very last psalm explicitly attributed to King David in the Psalter. In that glorious acrostic hymn, we listened as the old warrior king handed off the baton of praise to every generation, exalting Yahweh's unsearchable greatness, His open-handed generosity, and His everlasting kingdom. Today, as we step onto Day Two Thousand Nine Hundred Fifteen of our trek, we enter a brand-new, breathtaking chapter in the Psalms. We are beginning what biblical scholars call the "Final Hallel"—a grand, five-psalm crescendo comprised of Psalms One Hundred Forty-Six through One Hundred Fifty. Every single one of these five concluding psalms begins and ends with the majestic Hebrew command: Hallelu-YAH—Praise the Lord! We are moving from the individual testimony of David into the unanimous, triumphant doxology of the entire redeemed assembly. Today, we step directly onto the trail of Psalm One Hundred Forty-Six, verses one through ten, discovering where true human hope must be anchored. The first segment is: The Unceasing Vow: Praise with Every Dying Breath Let us open our ears to the exuberant opening movement of this psalm, where the writer groups his initial thoughts together in verse one and verse two. Praise the Lord! Praise the Lord, O my soul. I will praise the Lord as long as I live. I will sing praises to my God with my dying breath. The psalmist begins with a passionate, double declaration of praise, commanding his own inner being: “Praise the Lord, O my soul!” He vows to pour out praise to Yahweh as long as he lives, continuing this song of adoration even with his very dying breath. To fully grasp the theological depth of these opening lines, we must view them through the Ancient Israelite divine-council worldview. In the ancient mindset, human life-breath—known as neshamah or ruach—was not merely a biological phenomenon. It was the direct, miraculous gift of life imparted into human nostrils by the Sovereign Creator Himself. The gods of the surrounding pagan nations were lifeless idols, carved from stone or wood, completely unable to breathe, speak, or grant life to their worshippers. But Yahweh is the vibrant, uncreated Source of all animated existence! Therefore, as long as divine breath fills human lungs, that breath is designed to return to its Source in continuous, grateful worship. The psalmist pledges that even when physical strength wanes, and the body approaches the grave, the final sound slipping past human lips will be an anthem of praise to the King of heaven. The second segment is: The Folly of Trusting Mortals: Princes Returning to Dust The narrative takes a stark, brilliant turn in verse three and verse four, contrasting the eternal God with the extreme frailty of human political power. Don't put your trust in human leaders; no human can save you. When their breath departs, they return to the earth; on that very day their plans come to nothing. Here, the psalmist issues an urgent, unvarnished warning: “Don't put your trust in human leaders; no human can save you.” He explains that when their breath departs, these leaders return to the dust of the earth, and on that exact day, all their grand political, economic, and military plans dissolve into absolute nothingness. To truly appreciate this warning, we must examine it through the cosmic framework of ancient history. In the ancient Near East, kings, princes, and emperors routinely claimed divine status, presenting themselves as living gods or unique representatives of powerful spiritual principalities. Subjects were tempted to place their ultimate hope, national security, and personal salvation in these powerful monarchs. But the psalmist strips away all royal pretense! He deliberately uses the Hebrew word adam for human, reminding us that even the most powerful prince is made of adamah—mere dust from the ground. When a mortal leader dies, his spirit leaves him, his body decays back into the soil, and every policy, treaty, and military campaign he engineered vanishes instantly. In a world full of shifting geopolitics, human arrogance, and ideological promises, true wisdom urges us never to anchor our ultimate trust in mortal leaders who cannot even save themselves. The third segment is: The Cosmic Creator: The Unshakeable Anchor of Hope Having exposed the futility of trusting in mortals, the psalmist points us directly to the unshakeable anchor of true joy, combining the logical thoughts found in verse five and verse six. But joyful are those who have the God of Israel as their helper, whose hope is in the Lord their God. He made heaven and earth, the sea, and everything in them. He keeps every promise forever. The text bursts forth with a glorious beatitude, declaring, “Joyful are those who have the God of Israel as their helper, whose hope is in the Lord their God.” The writer then grounds this joy in Yahweh's cosmic credentials, proclaiming that He made heaven, earth, the sea, and everything in them, and that He keeps every promise forever! This is a massive, explicit claim of supreme cosmic authority! In the ancient divine-council worldview, foreign nations believed that their localized deities ruled specific, limited domains—Baal ruled the skies and weather, Yam ruled the chaotic seas, and Mot ruled the underworld. But the psalmist declares that Yahweh, the God of Jacob, is the singular, ultimate Architect of all three cosmic tiers: heaven, earth, and the roaring oceans! While human rulers break treaties, default on promises, and pass away into dust, the Creator of the cosmos remains forever faithful. His character is unchangeable, His power is limitless, and His covenants are backed by the full, eternal authority of His heavenly throne. The fourth segment is: The King of Justice: Liberator, Healer, and Protector The psalmist now unfolds the practical, compassionate expression of Yahweh's rule on earth, weaving together the contiguous thoughts in verse seven, verse eight, and verse nine. He gives justice to the oppressed and food to the hungry. The Lord frees the prisoners. The Lord opens the eyes of the blind. The Lord lifts up those who are weighed down. The Lord loves the godly. The Lord protects the foreigners among us. He cares for the orphans and widows, but he frustrates the plans of the wicked. Look at this magnificent, nine-fold manifesto of divine justice! Yahweh gives justice to the oppressed, food to the hungry, freedom to prisoners, vision to the blind, and comfort to those weighed down by life's heavy burdens. He loves the godly, protects vulnerable foreigners, and sustains orphans and widows, while actively dismantling and frustrating the schemes of the wicked. This passage provides a staggering portrait of divine kingdom ethics. In the ancient world, pagan deities and earthly tyrants catered exclusively to the elite, exploiting the poor, the stranger, and the fatherless to build their monuments. But Yahweh proves His supreme kingship precisely by championing the most vulnerable and marginalized members of society! Notice how every single action is prefixed with the divine name: The Lord frees, The Lord opens eyes, The Lord lifts up, The Lord protects! This list directly anticipates the miracle ministry of Jesus Christ, who entered human history to fulfill these exact words—healing the blind, feeding the hungry, liberating spiritual captives, and bringing the gospel to the poor. Furthermore, while Yahweh embraces the humble, He sets Himself in direct opposition to the arrogant, ensuring that their oppressive plans will ultimately crumble into chaos. The fifth segment is: The Eternal Reign: Zion's Unending Anthem The psalm reaches its ultimate, triumphant crescendo in verse ten,...

Frailty doesn't usually begin with a dramatic fall - it often starts with subtle changes that are easy to overlook, from slowing down when getting out of a chair to avoiding stairs or walking less. Michelle Martin speaks with Associate Professor Tim Xu from the Singapore Institute of Technology about the early warning signs of frailty, why mobility loss is not an inevitable part of ageing, and what older adults and their families can do to maintain strength, balance and confidence. They also discuss new research into SIT's 12-week "Say No to Frailty" programme, how community rehabilitation is helping seniors remain independent in their own homes, and the habits we should all adopt now to help us live longer and stronger.See omnystudio.com/listener for privacy information.

In which Yer Boys talk about the best movie Presidents ever; mix up Bills; earning the audience's trust as easily as possible; and the perfect time to go pee.

Six days before he sat down for this conversation, he ran a marathon. Then he explained what the race did to his brain. When you run 26 miles and your glycogen runs out, your brain still needs energy, so it starts stripping the fatty myelin off its own neurons and burning it for fuel. MRI scans caught a 20% drop in myelin up to two months after a marathon, and cognitive testing showed real impairment for about a month. In this episode, Louisa sits down with Brady Holmer, exercise physiologist, 2:24 marathoner, and author of VO2 Max Essentials, for one of the most practical conversations on aerobic fitness, brain health, and longevity the show has recorded. They cover why "marathon brain" is real but temporary, the menopause parallel where a starved brain catabolizes its own white matter, and whether pre-loading ketones or omega-3s can protect your myelin through a hard endurance effort. Then Brady breaks down VO2 max the way almost nobody does: not as a heart-and-lung number, but as a five-step oxygen cascade running from your lungs to your mitochondria, and why the bottleneck moves from your heart to your muscles as you age. You will learn the exact VO2 max floor below which everything becomes a maximal effort, the "50 at 50" target, and why women should aim for 40 to 50. Brady also lays out how the brain itself gates your fitness through myokine signaling, why the one to two hours after training may matter more than sleep for adaptation, and the truth about "non-responders" and the IGF binding protein biology behind trainability. Then the protocols: why the Norwegian 4x4 beats Tabata for VO2 max, how sauna and post-exercise ketones amplify the same session, why sleep consistency beats sleep duration, and the single weekly workout Brady says everyone should be doing for both VO2 max and brain health over the next decade. Reduce your risk of Alzheimer's with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. TOPICS DISCUSSED 00:00 Intro: Marathon Brain and the Number That Predicts How Long You Live 00:40 Does Running a Marathon Really Damage Your Brain? 01:04 The Study: 20% Myelin Loss on MRI After a Marathon 02:16 Impaired Cognition for a Month, Then Full Recovery 03:28 Why It Happens: The Brain Burns Its Own Myelin for Fuel 04:44 The Menopause Parallel: Brain Glucose Starvation and White Matter 05:57 Can Ketones and BHB Protect the Brain During a Marathon? 06:42 How Marathon Runners Should Fuel to Protect Cognition 08:22 VO2 Max: The Strongest Predictor of Mortality and Longevity 09:00 The Oxygen Cascade: What VO2 Max Actually Measures 11:08 Why VO2 Max Matters More As You Age 12:10 The VO2 Max Floor for Frailty and Daily Living 13:11 VO2 Max as a Brain Metric: Averages by Age and Sex 14:20 The "50 at 50" Target and What Women Should Aim For 15:09 The Female Masters Athlete Study and the VO2 Max Bank Account 16:01 How Your Brain Knows It Is Getting Fitter: Myokines 17:41 Mouse Studies: Block the Brain Signal, Lose the Adaptation 18:37 The Post-Workout Recovery Window That Drives Adaptation 19:53 What Kind of Rest Actually Works After Training 20:50 KetoneIQ: Clean Fuel for the Brain 21:50 Qualia Magnesium: Recovery and Deep Sleep 22:45 The Mission: Why Science Is the New Breaking News 27:25 Attacking VO2 Max From a Different Angle: What Is Your Bottleneck? 28:06 Central vs Peripheral: Heart, Muscle, and Mitochondria 30:20 Spotting Mitochondrial Dysfunction With a Simple Lactate Test 33:18 Training Each Link in the Oxygen Cascade 34:41 Targeting the Lungs: Inspiratory Muscle Training 36:19 Iron, Hemoglobin, and Heat as an Altitude Mimic 38:56 Exercise Hemolysis: Why Runners Break Down Red Blood Cells 39:59 Why Investors and CEOs Are Chasing VO2 Max 40:42 What Is Good for the Heart Is Good for the Brain 42:02 Exercise Snacks vs Deliberate Training as You Age 44:41 HIIT for Stroke Volume: Why the Norwegian 4x4 Works 45:43 4x4 vs Tabata and the 2 to 8 Minute Interval Sweet Spot 46:57 Using Heart Rate and Exertion to Train VO2 Max 48:02 Where AI Is Entering Endurance Coaching 49:14 Timeline Mitopure: Powering Your Mitochondria 50:16 Cozy Earth: Better Bedding, Better Sleep 51:04 Responders vs Non-Responders and the IGFBP Biology 55:35 How to Amplify Adaptation From the Same Training Load 56:39 Heat, Post-Exercise Ketones, and Getting the Basics Right 58:14 Sleep Consistency Beats Sleep Duration 01:00:24 The One Weekly Workout for VO2 Max and Brain Health Thank you to our sponsors KetoneIQ: https://ketone.com/NEURO for 30% OFF Qualia: https://qualialife.com/NEURO for 50% off Timeline: https://timeline.com/NEURO for Mitopure Cozy Earth: https://cozyearth.com use code NEURO for 20% off I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0  Instagram: https://www.instagram.com/louisanicola_/  Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices

The longevity world has convinced a generation of women that protein is shortening their lives. The science says they've got it backwards and the people hurt most are the ones who need protein most.In this episode, Dr. Gabrielle Lyon breaks down the protein-and-longevity fear, steelmans the strongest case against protein, then walks through what the evidence shows:The RDA (0.8 g/kg) is a deficiency floor, not a target, the intake one camp calls "dangerously high" is what federal guidelines and expert groups now recommend (1.2–1.6 g/kg)The IGF-1–cancer link is tiny (a 3–11% risk bump vs. smoking's 1,000–2,000%), and the IGF-1–mortality curve is U-shaped: the lowest levels carry ~40% higher death riskSarcopenia roughly doubles death risk (3.5× with frailty) and perimenopause stacks anabolic resistance on top, exactly when women are told to fear the foods that defend themBy the end, you'll understand the mTOR and IGF-1 science well enough that nobody online can scare you off your own dinner, plus a simple Monday-morning plan: adequate protein, front-loaded, built on minimally processed foods, with heavy lifting to match.Thank you to our sponsors:BodyHealth - Use the code LYON20 to get 20% off your first order https://bit.ly/4f7ZqM5 Our Place - Upgrade your kitchen with Our Place today. Visit https://bit.ly/4vT4cEr and use code DRYLON for 10% off sitewide. That's F-R-O-M-O-U-R-P-L-A-C-E DOT COM / D-R-L-Y-O-N and use code DRLYON for 10% off sitewide. With a 100-day trial, you can try it completely risk-free.Lucy Get 20% off your next order with code DRLYON at https://lucy.co/, or find yours in store at https://bit.ly/4ybQCxH Explore More from Dr. Gabrielle LyonPremium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.comWeekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/Apply to become a patient: Personalized care with Dr. Lyon's clinical team https://drgabriellelyon.com/new-patient-inquiry/Connect with Dr. Gabrielle Lyon:Instagram: https://www.instagram.com/drgabriellelyon/TikTok: https://www.tiktok.com/@drgabriellelyon X (Twitter): https://x.com/drgabriellelyonFacebook: https://www.facebook.com/doctorgabriellelyon Chapters00:00 - Introduction: Is Protein Really Shortening Your Life?02:30 - Who the Protein Fear Hurts Most03:29 - What mTOR Is (Two Complexes)07:29 - The RDA Deception: High vs Low Protein12:00 - The Falcone Reanalysis of Levine 201416:00 - The Strongest Case Against Protein21:00 - Why Rodent Data Isn't Human Data26:08 - The IGF-1 Cancer Story, Link by Link29:00 - The U-Shaped Mortality Curve32:00 - Insulin, Carbs, and Active IGF-134:30 - Sarcopenia, Frailty, and Death Risk35:55 - Perimenopause and Anabolic Resistance38:00 - Red Meat, TMAO, and Plant Protein Myths39:51 - The Honest Verdict: Processed Meat44:00 - How Much Protein and Your Monday PlanIf you found this episode valuable, share it with someone who would benefit from it.Disclaimers: This episode includes paid sponsorships. The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

A new sermon is available:Professor Roger Lewis' sermon for July 12, 2026.Scripture Reading - 1 Peter 1:22-25, Psalm 103:15-18 Frailty Professor Roger Lewis

In this episode of the Optimal Body podcast, Doctors of Physical Therapy Doc Jen and Doctor Dom explore the critical link between walking speed and overall health in older adults. They discuss research showing that resistance training can significantly improve gait parameters, emphasizing that muscle power is the most important modifiable factor influencing walking speed. The hosts highlight key exercise like calf raises, hip abduction, and squats, stressing the need for progressive overload to stimulate real muscle adaptation and improve gait. They encourage listeners of all ages to prioritize strength training to reduce fall risk, support cognitive health, and improve longevity. Ultimately, the episode underscores health tips on how targeted exercise can improve gait and overall quality of life. Zulu Weighted Vest: Upgrade your everyday movement with the ZULU Weighted Vest — designed to increase calorie burn, naturally engage your core, and improve posture with every step. Perfect for walks, workouts, and daily errands. Use code OPTIMAL for 20% off at checkout. Needed Discount: Jen trusted Needed Supplements for fertility, pregnancy, and beyond! Support men and women's health with vitamins, Omega-3, and more. Used by 6,000+ pros. Use code OPTIMAL for 20% off at checkout! We Think You'll Love: Free Longevity Webinar Jen Health Discount Jen's Instagram Dom's Instagram YouTube Channel For full show notes and resources visit https://jen.health/podcast/468 What You'll Learn: 2:01 Gait Speed as the Sixth Vital Sign 4:43 Why Walking Speed Matters 6:16 Gait Speed and Longevity 8:50 The Importance of Muscular Power 9:37 Preventing Age-Related Muscle Loss 11:05 Key Findings from the Research 12:42 The Importance of Progressive Overload 15:30 Most Effective Exercises for Gait Speed 16:10 How to Progress Exercises Safely 19:20 Applying These Principles to Daily Life 20:14 Starting a Strength Training Routine 21:41 Training to Failure Explained 23:27 The Value of Supervised Training Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

—Sermon text:Psalm 90

7/1/26. Five Minutes in the Word scriptures for today: Galatians 4:13. God Uses Paul's Frailty. Resources: copilot; biblehub.com; logos.com; Blog for this lesson: https://minutesword.blogspot.com/2026/07/historical-connection-between-pauls.html Podcast website: https://www.hwscott.net/podcast.php YouTube: https://m.youtube.com/@hhwscott Listen daily at 10:00 am CST on https://kingdompraiseradio.comLISTEN, LIKE, FOLLOW, SHARE! #MinutesWord; @MinutesWord; #dailybiblestudy #dailydevotional #Christian_podcaster #CommissionsEarned Pulpit Commentary (this is an D) https://amzn.to/40XhL83

It's been said that desperate conditions make for strong petitions. When we find ourselves facing a serious illness, and death comes knocking at our door, our perspective on life tends to change. Next time on The Bible Study Hour with Dr. James Boice we'll be looking at Psalm 102, the cry of a desperate man seeking refuge in a mighty God. To support this ministry financially, visit: https://www.oneplace.com/donate/81/29?v=20251111

Jacob Chacko – Genesis 35

We are on an abbreviated summer show schedule and this week we have questions from a person recovering from a break up and feeling emotionally fragile and another writer asking if GLP 1s can treat addiction. Join our patreon!Listen ad-free, get the show a day early and enjoy the pre-show hang out on the same app you're using RIGHT NOW at www.Patreon.com/Therapy where you can also access our vast library of deep dives, interviews, skill shares, reviews and rants as well as our live discord chat!If you are an Apple user please rate us!If you are a Spotify user, please rate us!Submit a question to the show!Help us reach #1 on Goodpods!Interested in Nick's mental health approach to fitness? Check out www.MentalFitPersonalTraining.comCheck out Dr. Jim's book "Dadvice: 50 Fatherly Life Lessons" at www.DadviceBook.comGrab some swag at our store, www.PodTherapyBaitShop.comPlay Jim's Neurotic Bingo at home while you listen to the show, or don't, I'm not your supervisor.Submit questions to:www.PodTherapy.netPodTherapyGuys@gmail.comFollow us on Social Media:FacebookInstagramTwitterResources:Suicide Prevention Lifeline - 1-800-273-8255.Veterans Crisis Line - 1-800-273-8255.Substance Abuse & Mental Health Services Administration (SAMHSA) National Helpline - (1-800-662-HELP (4357)OK2Talk Helpline Teen Helpline - 1 (800) 273-TALKU.S. Mental Health Resources Hotline - 211

In this episode, I'm joined by friend of the show Logan to discuss the complexity of faith and family dynamics in Frailty. We're also discussing Old Testament themes, Bill Paxton's career and the great state of Texas! Listen: Ghoulish UniversityWatch:The Making of FrailtyRead:Dread Central With Brent Hanley and David Blocker

In this episode, I'm joined by friend of the show Logan to discuss the complexity of faith and family dynamics in Frailty. We're also discussing Old Testament themes, Bill Paxton's career and the great state of Texas! Listen: Ghoulish UniversityWatch:The Making of FrailtyRead:Dread Central With Brent Hanley and David Blocker

Happy Father's Day as we get together with Bill Paxton and an ax! We're finally covering Frailty! We'll talk about how the ax got named Otis, try to keep our cool with all the Matthew McConaughey sexiness, and try to be more assertive while getting an oil change!Grab our TCTGY Pride Merch, with proceeds benefiting River City Pride in Evansville, IN!www.ComingtoGetYouMerch.com

In this episode of Popcorn & Catch-Up, we continue the 2026 season with a discussion of Frailty.We'll be discussing the film in depth, so be sure to watch it before listening to the episode. And don't forget to let us know what you think on X/Facebook/Bluesky!Tell your friends about Popcorn & Catch-Up!Thanks for listening!

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As we age, fragility, frailty, and mobility become crucial aspects of our well-being. Understanding these challenges helps us navigate ageing with dignity, strength, and independence. In this insightful episode of Ageing Gracefully, Fr. Juventius Andrade hosts a discussion with two distinguished experts:

In Part 2, we dive deeper into the themes of fragility, frailty, and mobility, exploring how they intersect with the aging process. This episode features insightful discussions with experts Fr. Juventius Andrade, Dr. Pratibha, and Dr. Ravindran. Together, they shed light on the physical and emotional challenges that arise as we age, offering advice on maintaining strength, resilience, and independence. From strategies to improve mobility to understanding the nuances of frailty, this episode is a thoughtful resource for those seeking to age gracefully, with dignity and health in mind.

In this insightful episode of Ageing Gracefully, we continue our conversation on the challenges and realities of ageing, focusing on fragility, frailty, and mobility. Fr. Juventius Andrade, along with esteemed medical experts Dr. Pratibha and Dr. Ravindran, discuss the physical and emotional aspects of ageing, addressing key concerns such as maintaining strength, preventing falls, and enhancing mobility in later years.With a compassionate and practical approach, our panel explores strategies to promote independence, resilience, and quality of life as we age. Whether you're a senior looking for guidance, a caregiver supporting a loved one, or simply interested in understanding the ageing process, this episode offers valuable insights and encouragement to embrace ageing with grace and dignity.Join us for this engaging discussion, as we continue to explore how faith, medicine, and mindful living can help navigate the golden years with wisdom and hope.

Why Candace Owens is in Russia http://americanfinancing.net/craig Selena Studio Art https://www.etsy.com/shop/selenastudioart/?etsrc=sdt Jupiter Joe YouTube Channel Radio Show and Podcast https://www.youtube.com/@jupiterjoemoneyshow/videos https://www.jupiterjoe.com TV Insiders https://open.spotify.com/show/6AtTqqfoJNj1yHYLNCz80c?si=d7287583b8484d7b&nd=1&dlsi=801babeb79b847f4 The One https://www.amazon.com/dp/B0H321BQ4N?ref_=cm_sw_r_ffobk_cp_ud_dp_6H1T3P8D9RS159N6JD2T&bestFormat=true A Chicken was There Celebrate America https://www.amazon.com/dp/B0H1MQL1W6?ref_=cm_sw_r_ffobk_cp_ud_dp_F0E0XDY35X7VVDTM5EDX&bestFormat=true Frailty of Fact https://www.amazon.com/dp/B0G6V5TXSS?ref_=cm_sw_r_ffobk_cp_ud_dp_Q1A70AGYH7W157EN71BW&bestFormat=true Kindred https://www.amazon.com/dp/B0GQJ7CR3T?ref_=cm_sw_r_ffobk_cp_ud_dp_CB4014ARFP9K4EFCAVQ8&bestFormat=true Save up to 80% off Top MyPillow Prodcuts with our Promo Code KANE at Checkout https://www.mypillow.com/kane Thank you to our Top Patreon Supporters! Andrew and Connie, Cristine, ETW, Chuck, Pamela, Nick, Wesley,  Heather, David, Maria in Texas, Alice, LeeZep, Shawana, George, Brandon, John S, Frank, Dale,David,Laura B, Rob L. SFjr. Irene Support the show and become a Patreon Supporter! https://www.patreon.com/realbriancraigshow https://briancraigshow.com LaPorta Roofing  https://www.laportaroofing.com    

At just 16, Ellyse Perry was the youngest person to ever debut for the Australian International Cricket team. 13 days later, Ellyse debuted for the Matildas.

The True History of Graham Platner http://americanfinancing.net/craig Selena Studio Art https://www.etsy.com/shop/selenastudioart/?etsrc=sdt Jupiter Joe YouTube Channel Radio Show and Podcast https://www.youtube.com/@jupiterjoemoneyshow/videos https://www.jupiterjoe.com TV Insiders https://open.spotify.com/show/6AtTqqfoJNj1yHYLNCz80c?si=d7287583b8484d7b&nd=1&dlsi=801babeb79b847f4 The One https://www.amazon.com/dp/B0H321BQ4N?ref_=cm_sw_r_ffobk_cp_ud_dp_6H1T3P8D9RS159N6JD2T&bestFormat=true A Chicken was There Celebrate America https://www.amazon.com/dp/B0H1MQL1W6?ref_=cm_sw_r_ffobk_cp_ud_dp_F0E0XDY35X7VVDTM5EDX&bestFormat=true Frailty of Fact https://www.amazon.com/dp/B0G6V5TXSS?ref_=cm_sw_r_ffobk_cp_ud_dp_Q1A70AGYH7W157EN71BW&bestFormat=true Kindred https://www.amazon.com/dp/B0GQJ7CR3T?ref_=cm_sw_r_ffobk_cp_ud_dp_CB4014ARFP9K4EFCAVQ8&bestFormat=true Save up to 80% off Top MyPillow Prodcuts with our Promo Code KANE at Checkout https://www.mypillow.com/kane Thank you to our Top Patreon Supporters! Andrew and Connie, Cristine, ETW, Chuck, Pamela, Nick, Wesley,  Heather, David, Maria in Texas, Alice, LeeZep, Shawana, George, Brandon, John S, Frank, Dale,David,Laura B, Rob L. SFjr. Irene Support the show and become a Patreon Supporter! https://www.patreon.com/realbriancraigshow https://briancraigshow.com LaPorta Roofing  https://www.laportaroofing.com    

Nutritionist Leyla Muedin discusses research showing simple strength tests—grip strength and a five-rep sit-to-stand chair test—predict longevity in older women. In a University at Buffalo study of over 5,000 women ages 63–99 followed for eight years, stronger grip and faster chair-stand times were linked to lower mortality; every additional 7 kg of grip strength corresponded to a 12% reduction in death risk, and faster chair-stands were also associated with improved survival, even after adjusting for activity, cardiovascular fitness, and inflammation. She emphasizes prioritizing muscle-strengthening alongside aerobic exercise and suggests accessible resistance options (weights, bodyweight moves, or household items) with professional guidance as needed. She then cites UK Biobank data linking long-term statin use to declines in grip strength and appendicular lean mass, urging discussion with physicians and added vigilance, especially for those also using GLP-1 drugs that may reduce protein intake and muscle mass.

Contact us and share your opinionIn this episode…GP Collective Action Month 2 - Medication Optimisation SoftwareA “hyper focus” on GP access at the expense of frailty management is discussed at the Public Accounts Committee at WestminsterGPCE Committee funding at risk as GPDF debate motion to cease funding in favour of an alternative  way to secure a “Plan B” dentistry like model for General PracticeBoost your triage skills with our dynamic 5-session live webinar course, tailored for primary care clinicians. Led by Dr. Gandalf and Dr. Ed Pooley, this comprehensive training covers all facets of remote patient triage—digital, on-call, and more. Gain practical knowledge, exclusive tips, and direct access to our experts through open Q&A sessions. Elevate your ability to manage primary care challenges effec Join Dr Mike as he shares how to get started and fly using EMIS to make your life easier with this clinical systembit.ly/EMIScourse

This week, we’re honored to welcome back a dear friend of the show—the iconic artist, singer, and GRAMMY winner Amy Grant. Amy joins us to share her heart about her first album of original material in thirteen years, the deeply personal project titled “The Me That Remains.” In this moving interview, Amy opens up about the profound life events that inspired her new music—navigating the tender journey of aging and caring for her parents at the end of their lives, her ongoing recovery from a serious bike accident, and the enduring joy of creating music that she feels grateful to share with the world. Later in the episode, we’ll hear from Andrew Osenga, a Nashville-based musician, writer, and podcaster. Andrew spent years trapped in the tension between his private doubts and the crushing expectation of performing as a Christian artist. Growing up, image was everything, and he struggled under the pressure to appear “put-together”—even when he felt broken inside. It took devastating loss—including his home flooding, displacing his family, and his wife’s grueling cancer journey—for him to finally break free from performance-driven faith. Links, Products, and Resources Mentioned: Jesus Calling Podcast Jesus Calling Jesus Always Jesus Listens Past interview: Diane Chew Upcoming interview: Annie Bosko Amy Grant The Me That Remains - Album by Amy Grant The Book of Forgiving - Book by Desmond Tutu and Mpho Tutu The 6th Of January (Yasgur's Farm) - Song by Amy Grant Andrew Osenga How to Remember: Forgotten Pathways to an Authentic Faith - Book by Andrew Osenga Caedmon’s Call Young Life Interview Quotes: “Don't ever be afraid to speak the truth of what is right now.” - Amy Grant “Life is happening to all of us all the time, and we have to be gentle with ourselves and gentle with each other.” - Amy Grant “I feel like the arts are good medicine for everybody.” - Amy Grant “We are all part of humanity and we all experience good, hard and unresolved unrest; how do we sit in it and find our way forward?” - Amy Grant “When [accidents or illnesses] come, you need people in your life to remind you what matters: you are loved by God, and if you’re still breathing, the adventure continues.” - Amy Grant “Jesus doesn’t want us to pretend. He wants us to be the people He created. He doesn’t love a fake image of me. He loves me.” - Andrew Osenga “There have been a number of experiences in my life that have helped redirect me towards a more quiet and grounded way of being with God, moving from performance towards presence.” - Andrew Osenga “The wonderful thing is Jesus doesn’t meet us in our perfection, He meets us in our suffering. Jesus is introduced to us in the Bible as a man of sorrows. And so, it’s not that we have to stay there all the time, knowing that is a part of our story. Being able to be honest about that allows us this freedom to be people of joy rather than having to sort of put on a happy face.” - Andrew Osenga “We can say that we can hold suffering and joy in both hands at the same time, and I think those are the people that we’re drawn to. And that’s when we can start to speak with an authentic voice. That takes time to learn how to do that, and that takes, honestly, walking through seasons of both suffering and joy to be able to learn how to do that.” - Andrew Osenga “We live in a culture that prizes things like novelty, speed, and constant reinvention. I think these practices like lament, confession, shared prayer, and silence can be a form of resistance, pushing back against this speed, the hectic life, against the doom scroll.” - Andrew Osenga ________________________ Enjoy watching these additional videos from Jesus Calling YouTube channel! Audio Episodes: https://bit.ly/3zvjbK7 Bonus Podcasts: https://bit.ly/3vfLlGw Jesus Listens: Stories of Prayer: https://bit.ly/3Sd0a6C Peace for Everyday Life: https://bit.ly/3zzwFoj Peace in Uncertain Times: https://bit.ly/3cHfB6u What’s Good? https://bit.ly/3vc2cKj Enneagram: https://bit.ly/3hzRCCY ________________________ Connect with Jesus Calling Instagram Facebook Twitter Pinterest YouTube Website TikTok Discover more Christian podcasts at lifeaudio.com and inquire about advertising opportunities at lifeaudio.com/contact-us.

Contact us and share your opinionVote for your winner here: https://us22.list-manage.com/survey?u...Join the TPP conference: https://mailchi.mp/tpp-uk/tpp-systmon...Join DrGandalf and Team GP in primary care as they show off how to use TPP SystmOne to innovate care and support Neighbourhoods with the chance to win £1000 for each award.00:00 TPP Awards intro01:13 Previous Award WINNERS02:30 Meet the Nominees04:16 CLAS by Countesthorpe Health Centre15:56 Majic NAV by Kings Medical Practice27:30 Cancer workflow by Parkside Medical Centre38:29 INT with Spen Health PCN48:35 Frailty and CGA by Pathfields Medical Group56:40 Vote and Major newsBoost your triage skills with our dynamic 5-session live webinar course, tailored for primary care clinicians. Led by Dr. Gandalf and Dr. Ed Pooley, this comprehensive training covers all facets of remote patient triage—digital, on-call, and more. Gain practical knowledge, exclusive tips, and direct access to our experts through open Q&A sessions. Elevate your ability to manage primary care challenges effec Join Dr Mike as he shares how to get started and fly using EMIS to make your life easier with this clinical systembit.ly/EMIScourse

"We want to make sure that we discuss the details of the treatment and what treatments there are, whether it's an oral drug, whether it's a subcutaneous injection or an IV injection, [the patient's] potential for responding, whether this treatment is curative or supportive, and what the number of visits are. All of those different pieces of information that go into the decision-making process are really important," ONS member Sara Tinsley-Vance, PhD, APRN, AOCN®, nurse practitioner and quality-of-life researcher at Moffitt Cancer Center in Tampa, FL, told Lenise Taylor, MN, RN, AOCNS®, TCTCN™, oncology clinical specialist at ONS, during a conversation about myelodysplastic syndrome (MDS) treatment considerations. Music Credit: "Fireflies and Stardust" by Kevin MacLeod Licensed under Creative Commons by Attribution 3.0  Earn 0.5 contact hours of nursing continuing professional development (NCPD) by listening to the full recording and completing an evaluation at courses.ons.org by May 15, 2027. The planners and faculty for this episode have no relevant financial relationships with ineligible companies to disclose. ONS is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation. Learning outcome: Learners will report an increase in knowledge about the treatment considerations for MDS. Episode Notes  Complete this evaluation for free NCPD.  ONS Podcast™ episodes: Episode 411: An Overview of Myelodysplastic Syndrome for Oncology Nurses Episode 256: Cancer Symptom Management Basics: Hematologic Complications ONS Voice articles: FDA Approves Luspatercept-Aamt for Anemia in Adults With MDS Infection Prevention for Oncology Nurses Manage Cancer-Associated Anemia With Erythropoietin-Stimulating Agents Whole-Genome Sequencing May Guide Treatment Choices for AML and MDS Clinical Journal of Oncology Nursing articles:  Reducing Effects of Hospital-Associated Deconditioning in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation Resilience in Older Adults Diagnosed With Cancer and Receiving Chemotherapy Targeted Drug Therapies: Beyond Blood Counts and Chemistries Oncology Nursing Forum article: Frailty in Patients With Hematologic Malignancies and Those Undergoing Transplantation: A Scoping Review ONS books:  BMTCN™ Certification Review Manual (second edition) Hematopoietic Stem Cell Transplantation: A Manual for Nursing Practice (third edition) ONS course: Hematopoietic Stem Cell Transplantation™ ONS Learning Library: Hematology, Cellular Therapy, and Stem Cell Transplantation ONS Symptom Intervention resources: Prevention of Infection: General Prevention of Infection: Transplant Aplastic Anemia and MDS International Foundation: MDS Drugs and Treatments Blood Cancer United: MDS Treatment HealthTree Foundation Myelodysplastic Syndromes Foundation To discuss the information in this episode with other oncology nurses, visit the ONS Communities.  To find resources for creating an ONS Podcast club in your chapter or nursing community, visit the ONS Podcast Library. To provide feedback or otherwise reach ONS about the podcast, email pubONSVoice@ons.org. Highlights From This Episode "The goals that I try to consolidate to make sure they're consistent with the patient's goals are to improve their counts, especially the anemia or cytopenias. If they're getting blood transfusions, we want to reduce the number of transfusions that they receive because we know that's linked to reduced overall survival, and it really impacts quality of life. ... And then for high-risk patients, it's a more serious discussion because we know that they are the ones who can progress to acute myeloid leukemia (AML). And we're trying to delay progression to AML. That means we're trying to improve their survival and we're also trying to manage their cytopenias and decrease their infection risk." TS 2:28 "If we look at approvals for low-risk disease and high-risk disease, those were really made based on the Revised International Prognostic Scoring System (IPSS-R) and sometimes the International Prognostic Scoring System (IPSS). Under those classification systems, when we think of lower-risk MDS, we think of patients who are primarily anemic but don't have increased blasts in their bone marrow. ... For higher-risk MDS, we want to have that discussion with those patients because their life expectancy is much shorter than patients with lower-risk MDS. We want to see if hematopoietic stem cell transplant would be something that they would be interested in if they don't have a lot of comorbidities and are relatively healthy." TS 11:41 "There are a lot of things to consider—[patients'] blood counts, comorbidities, whether they're frail, and what their goals are. There are some patients where there's no way they would want to go through transplant. And some patients want to be cured, so it just depends on your patient." TS 14:22 "I think of hematopoietic allogeneic transplants as a treatment for more of the patients with higher-risk MDS. ... With the Molecular International Prognostic Scoring System (IPSS-M), a patient can have pretty good blood counts and not have increased blasts in the bone marrow. You could send them for a transplant referral upfront without having to give them additional treatment. ... There is a recent publication that said if a patient doesn't have more than 10% blast, you could refer to transplant as a first option. ... Also, if you had a lower-risk patient who is relatively young and doesn't have any other treatment options, this would also be a patient that you could refer to transplant to see if we could care for them, and then they wouldn't have to be getting transfused all the time." TS 21:12 "I think that we often think low-risk, no treatment needed, but it depends on the person. They often need ongoing supportive care to manage their symptoms even if they're not getting treatment. And just because we're not treating them, active observation, bringing them in to see how they're doing, if they've had infections, if their blood counts are changing, that is paying attention to them and doing something. Just because they're low-risk doesn't mean they don't need anything and we can just schedule for a one-year follow-up." TS 26:30

What if every "non-compliant" patient was actually a signal that the system isn't working for them? In this episode, Jamie sits down with Jaclyn Taylor, Clinical Strategy Director at Your Health and a nurse practitioner who started her career as a home-based provider in 2020 — thrown straight into the fire of COVID, isolated patients, and a healthcare world rewriting itself in real time. What she saw inside patients' homes — medications scattered on tables, food insecurity, missing transportation — changed how she thinks about every chart she's ever read. You'll hear: Why a nurse-first pathway gives nurse practitioners a fundamentally different lens than a medical school pathway — and why patients feel it What working across home care, telehealth, trauma, and wellness teaches you about treating the whole human, not just the diagnosis Why trauma surgery turned Jacqueline into a believer in proactive, longitudinal care — and what gets missed when we only meet patients after something has already gone wrong The two words she uses to describe what's most broken in traditional healthcare: fragmentation and misalignment How empathy stops being a poster and starts being operational — built into the design of care itself If you've ever felt invisible inside the healthcare system, or if you're the one trying to fix it, this conversation reframes the whole game. Press play. www.YourHealth.Org

Dr. Hope Rugo and Dr. Peter Lee discuss frailty, geriatric assessments, and personalized care for older adults with genitourinary cancer. They highlight screening guidelines, treatment considerations, multidisciplinary interventions, and the emergence of AI and digital health tools in geriatric oncology. LINK TO FULL TRANSCRIPT    

Ecclesiastes 5:8–6:12 - exposes the emptiness of trusting in government, money, possessions, or achievement to give lasting meaning. Solomon shows that wealth and success often increase anxiety rather than peace, and a life spent chasing more can still leave the soul unsatisfied. Even under God's sovereignty, human choices still matter, and people remain responsible for how they live and what they pursue. Instead of building life around endless striving, Solomon points toward a quieter rhythm of flourishing: enjoy meals with others, work faithfully, accept your limits, and practice gratitude. True joy is found not in prestige or accumulation, but in receiving everyday life as a gift from God, marked by contentment, meaningful work, shared community, and thankfulness toward the Giver of every good thing.

Episode 249: Deja vu hits us pretty hard this week as we review yet another film named Good Boy about a dog, but this one is from 2022 and Norwegian. Does it have the same bark or bite? Find out.Make sure to check back with us next week as we reveal all our sins, with 2001's Frailty.Become a supporter of this podcast: https://www.spreaker.com/podcast/a-cut-above-horror-review--6354278/support.

Episode 250: This week we have an axe to grind for Bill Paxton's 2001 hidden gem Frailty.With axe expert and podcast demon Charlie of Give Me Back My... the Podcast , on to give us aid in the fight against pure evil.Don't forget to come back next week, to celebrate 4/20 with 2006's Evil Bong.Become a supporter of this podcast: https://www.spreaker.com/podcast/a-cut-above-horror-review--6354278/support.

Frailty isn't just something that happens “later”; it's a gradual loss of resilience that can begin much earlier than most people think. Katy Bowman and Dr. Jeannette Loram unpack what frailty and pre-frailty mean biologically. They explore the five key hallmarks used to identify frailty, including walking speed and grip strength, and how a large proportion of people in their 30s and 40s already fall on the spectrum of pre-frailty.The conversation also explores the muscle–gut connection, explaining how frailty is influenced by exercise, diet, and the health of your microbiome. Katy and Jeannette also discuss the potential for rapid-onset frailty linked to the use of GLP-1 medications.Most importantly, frailty can be reversed and this episode focuses on what you can do. From simple ways to improve resilience through movement, nutrition, and rest, to understanding how your attitude toward aging might influence your resilienceEnhanced Show Notes and Full Transcript00:00 – Intro + Sponsors  01:30 – What Is Frailty (and Pre-Frailty)  03:00 – The 5 Hallmarks of Frailty  10:50 – How Pre-Frailty Can Start in Your 30s  12:40 – Muscle–Gut Connection & the Microbiome  19:40 – Exercise as “Fuel” for Your Microbiome  27:30 – Supplementation and the Psychology of Change  29:50 – GLP-1 Medication & Rapid-Onset Frailty  42:20 – Listener Question: Finding Glute Strength (Sponsored by Peluva)Resources and Books Mentioned:Joyspan by Kerry Burnight Frailty Sets In Far Earlier Than You'd Expect But You Can Reverse It, by David Cox in the New Scientist Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 biobank participants by Hanlon et al 2018Evidence For The Contribution Of Gut Microbiota To Age-Related Anabolic Resistance by Watson et al 2021Semaglutide Therapy and Accelerated Sarcopenia in Older Adults With Type-2 Diabetes: A 24-Month Retrospective Cohort Study by Ren et al 2025Connect, Move & Learn:Join Our Newsletter: Movement Colored GlassesFollow Katy on SubstackTry Katy's Virtual Studio Free for 7 days!Made Possible By Our Wonderful Sponsors:.My Happy Feet: Toe-spacing socks that gently realign toes for comfortable recovery—take 20% off with code MYDNAIkaria Design: The Soul Seat® offers height-adjustable, multi-position sitting—get 10% off new chairs and desks with code DNA10Venn Design: Beautifully upholstered ball-shaped Air Chairs that encourage dynamic sittingPeluva: Five-toe minimalist shoes that move like you do—take 10% off with code NUTRITIOUSMOVEMENTSmart Playrooms: Beautiful playroom design and movement-rich equipment—save 10% on monkey bars and rock-wall items with code DNA10Movemate: Active standing boards with smoothly articulating wooden slats. Designed to keep you moving without interrupting your focus.Thoughts/questions email us at podcast@nutritiousmovement.comYour Voice on the Podcast: Read The Credits 

In this episode, Sidney breaks down a movie with not one, but two unexpected twists, Frailty (2001).

Leyla Muedin, a registered dietitian nutritionist, discusses a UK Biobank analysis published in the Journal of Cachexia, “Sarcopenia and Muscle” (Nov 2025) linking continuous long-term statin use (e.g., Lipitor, Zocor, Crestor) to accelerated declines in grip strength and appendicular lean mass compared with never-users. Among 35,557 with follow-up data, grip strength declined by a mean 0.315 kg/year and appendicular lean mass by 0.057 kg/year in statin users; findings persisted after adjustment for age, sex, BMI, comorbidities, and a pharmacogenomic statin-response score. Leyla notes possible mechanisms (CoQ10/mevalonate pathway effects, mitochondrial dysfunction, apoptosis, calcium disruption, insulin resistance) and advises monitoring musculoskeletal health, supporting diet and regular physical activity, while not interpreting results as a reason to stop prescribing statins.

Joseph Mikhael, MD, MEd, FRCPC, FACP, FASCO, chief medical officer with the International Myeloma Foundation and professor in the Applied Cancer Research and Drug Discovery Division of the Translational Genomics Research Institute, has spent more than 25 years advancing the treatment of multiple myeloma. In this episode, he breaks down how improved survival, evolving frailty assessments, and the rise of therapies like CAR T and bispecific antibodies are reshaping care for an aging population, and he highlights the growing emphasis on quality of life, caregiver support, and expanding clinical trial access.

Why has Darwin's theory of evolution succeeded so dramatically? The official story, of course, is that it provides a sweeping and complete explanation of the development of life on Earth, with the claim that it's rock solid because it's grounded in an abundance of evidence. But when we take a closer look at that official story, we see that it actually resembles more of a myth, a legendary origin story that has been championed and propped up successfully for over 160 years. On this ID The Future, host Andrew McDiarmid treats you to a reading from False Messiah, a book by Neil Thomas recently published by Discovery Institute Press. The book provides valuable insight around the mythology of Darwinism as well as the mythical figure of Charles Darwin himself. To help us understand why Darwinism has persisted for so long, it's helpful to take a closer look at the forces that moved it forward and upheld it, lest we be tempted to think it has succeed purely on the strength of its scientific arguments. Source

Kevin and Erin discuss the horror "Classic": Frailty. Spoilers aplenty! Like and share this episode, and check us out at https://linktr.ee/TPodcastTWDie. TJ from http://introoutrobed.com custom-made our music! Use my special link https://zen.ai/OPqxxQiaqgDLKVIziDbCE-bL9F-GRRqYLBJ5f6qmlwU to save 30% off your first month of any Zencastr paid plan.

We welcome Joe Begos, Josh Ethier, and Matt Mercer on the show to chat Frailty, the Collateral soundtrack, and many more tangents.

As our patients' age progresses, so should our definition of 'recovery'. In this episode of BackTable OBGYN, Dr. Mary Ackenbom, associate professor of urogynecology and reconstructive pelvic surgery at the University of Michigan, is welcomed by host Dr. Amy Park to discuss improving outcomes for older surgical patients. --- SYNPOSIS Dr. Ackenbom shares her journey from studying finance at Ohio State to ultimately specializing in urogynecology. The conversation mainly focuses on perioperative cognitive health, particularly in aging populations, and how conditions like frailty and comorbidities impact surgical risk and recovery. Dr. Ackenbom highlights the importance of individualized patient care, early mobility, enhanced recovery protocols, and prehabilitation in improving postoperative outcomes. The episode also explores the prevalence of postoperative cognitive decline and offers practical insights on counseling and managing older patients undergoing urogynecologic surgery. --- TIMESTAMPS 00:00 - Introduction02:18 - Dr. Ackenbom's Journey to Urogynecology04:47 - Research on Brain Fog06:18 - Personal Support and Hobbies09:54 - Age vs Frailty in Surgery13:05 - Procedures with Perioperative Complexity16:11 - Counseling on Operative Risk20:10 - ERAS and Earlier Discharge23:35 - Patient Goals and Tradeoffs27:53 - Surgical Clearance and Preop Consults33:30 - Prehabilitation Basics36:24 - Minimally Invasive Surgery Benefits37:15 - Surgical Cognitive Complications with Age41:42 - Finding the Surgery Window46:05 - Cognitive and Frailty Screening50:01 - Guidelines for Perioperative Care52:52 - Future Research 54:07 - Conclusion --- RESOURCES Incidence of postoperative cognitive dysfunction in older women undergoing pelvic organ prolapse surgeryhttps://pubmed.ncbi.nlm.nih.gov/32827107/ ACS NSQIP/AGS Optimal Perioperative Care of the Geriatric Patienthttps://www.facs.org/media/y5efmgox/acs-nsqip-geriatric-2016-guidelines.pdf

Mommie dearest, the worst video ever produced, a truly great Kennedy, Abraham Lincoln and ecstasy, a vile word, don't fuck with my eye drops, a Guns N' Roses disaster, get Ruffalo some Ex-Lax, a kind of a boring day at the movies, a Nick Nolte sighting, a really enjoyable random Richard Gere movie, the cool as hell Will Patton, my favorite Carradine, a somewhat despicable woman, some streaming selections, and the sweet smell of success. Stuff mentioned: Secretary Kennedy and Kid Rock's Rock Out Workout (https://www.instagram.com/reel/DU33MUgiWo5/?hl=en), Cobra (1986),  Airplane (1980), Guns N' Roses "Welcome to the Jungle" (1987), Crime 101 (2026), Safe Men (1998), Heat (1995), The Mothman Prophecies (2002), The Butterfly Effect (2004), Coma (1978), Revenge of the Nerds (1984), 8 Million Ways to Die (1986), Frailty (2002), Blow Out (1981), Shocker (1989), Dragged Across Concrete (2018), and Unlawful Entry (1992), and Magnum, P.I. (1980-1988).

CardioNerds (Dr. Jenna Skowronski [Heart Failure Council Chair], Dr. Shazli Khan, and Dr. Josh Longinow) are joined by renowned leaders in the field of AHFTC (Advanced Heart Failure and Transplant Cardiology) and mechanical circulatory support, Dr. Jeff Teuteberg and Dr. Mani Daneshmand to continue the discussion of advanced heart failure therapies by taking a deep dive into the world of durable LVADs (Left Ventricular Assist Devices). In this episode, we will review the history of ventricular assist devices, the basics of LVAD function, selection criteria for LVAD therapy, and surgical nuances of LVAD implantation. Audio Editing by CardioNerds intern, Joshua Khorsandi. Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. CardioNerds Heart Success Series PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls There have been significant advances in the field of MCS/LVAD therapy since the first implanted LVAD in the 1960s, to the first FDA approved device in the early 2000's, to now the HM3 LVAD, with the most important change being a centrifugal flow/magnetically levitated design that led to minimized hemocompatibility-related adverse events (HRAE's) (MOMENTUM 3 trial comparing HM2 and HM3).  The REMATCH trial in 2001 was a pivotal trial for LVAD therapy, demonstrating that in a population of patients with advanced HF (70% IV inotrope dependent), LVAD therapy significantly improved survival at both 1 and 2 years as compared to medical therapy alone.    MOMENTUM 3 trial was a landmark trial for the HM3 device, showing that in a population of end stage HF patients (86% inotrope dependent, 32% INTERMACS 1-2, and 60% DT strategy), 5-year survival with HM3 was 58% and HM3 had lower HRAE's compared with HM2.  There are both patient-specific factors and surgical considerations when it comes to candidacy for LVAD therapy.  RV function prior to LVAD is a key determinant for success post-LVAD  Many patients being considered for LVAD may not have robust RV function, however, predicting RV failure after LVAD is exceedingly difficult.   In general, it doesn’t matter how bad the RV may look on imaging; we care more about the pre-LVAD hemodynamics (look at the PAPi and RA/wedge ratio).   What happens in the OR may be the most important determinant of how the RV will do with the LVAD!  Notes Notes drafted by Dr. Josh Longinow.  1. Historical background of heart pumps and LVADs  LVAD Evolution   FDA approval year  2001  2008  2012  2017  Pump  HeartMate XVE   HeartMate II  Heartware HVAD  HeartMate III  Flow/Design Features  Pulsatile Technology   Continuous flow Axial design  Continuous flow  Centrifugal design  Continuous flow   Full MagLev + Centrifugal design  The 1960's ushered in the first ‘LVADs', when the first air-powered ‘LVAD' was implanted. It kept the patient alive for four days before the patient expired.   The first generation of LVADs were pulsatile pumps   The first nationally recognized, FDA approved LVAD was the HeartMate XVE (late 1990s to early 2000s, REMATCH trial). The XVE pump used compressed air (pneumatically driven) to power the pump.   Prior to the XVE, OHT was the standard of care for patients with advanced, end-stage heart failure.   The second and third generations of LVADs were non-pulsatile, continuous flow devices and included the HVAD, HM2, and HM3 devices.   MOMENTUM 3 was a landmark trial for the HM3 device, showing that in a population of sick patients with end stage HF (86% inotrope dependent, 32% INTERMACS 1-2, and 60% DT strategy), 5-year survival with HM3 was 58% and HM3 had lower HRAE's compared with HM2.   The only pump that is currently FDA approved for implant is the HM3, although other pumps are in clinical trials (BrioVAD system, INNOVATE Trial).  2. What are LVADs, and how do they work?   In simplest terms, the LVAD is a heart pump comprised of several key mechanistic components:   Inflow cannula  Mechanical pump   Outflow cannula  Driveline  Controller/Power source  The HM3 differs from its predecessors (HM2 and HVAD) in several key ways;   HM3 is placed intrapericardial whereas the HM2 was placed pre-peritoneal.   Perhaps most importantly, the HM3 is a fully magnetically levitated, centrifugal flow pump, whereas the HM2 is an axial flow device.  Axial flow pumps are not magnetically levitated, leading to more friction produced between the ruby bearing's contact with the pump rotors, and higher rates of hemocompatibility related adverse events (HRAEs, i.e. pump thrombosis) and the HM2 was ultimately discontinued in favor of the HM3 (MOMENTUM 3 trial).  3. What do the terms ‘Destination Therapy' (DT) or ‘Bridge to Transplant' (BTT) mean when it comes to LVADs?   When LVADs first came on the stage, EVERYONE was a BTT; these early pumps weren't designed for long term use (I.e. REMATCH Trial, Heartmate XVE)  Destination therapy means the LVAD was placed in leu of transplant because there are contraindications to transplant   REMATCH trial brought about the concept of “Destination therapy”, comparing outcomes in patients (with contraindications for transplant) who received an LVAD vs optimal medical therapy  Bridge to transplant means we are placing the LVAD in a patient who may not be a transplant candidate at this moment in time (is too sick, or conversely, not sick enough), but may be down the line   Bridge to recovery is another term used when the LVAD is being placed for a patient we think may have a recoverable cardiomyopathy  4. What are some factors we should consider when assessing a patient’s candidacy for LVAD, in general, and from a surgical perspective?   Patient factors   Older age might push us towards thinking LVAD rather than transplant  In general, age > 70 is the cutoff for transplant, but this is not a hard cut off and varies institution to institution    In general, think about things that help predict recovery after a major surgery; Frailty and Nutritional status are important, we try to optimize these prior to LVAD implant   Right ventricular function remains the Achilles heel of LV support  We know that needing temporary RV support post LVAD puts you on a different survival curve than patients who don’t need RVAD support  Studies have not been able to successfully predict who will develop RV failure after LVAD implantation  What happens in the time between when the patient goes to the OR and when they get back to the ICU is an important determinant who might develop RV failure post LVAD   Surgical techniques such as implanting the HM3 in the intra-thoracic cavity, rather than intra-pericardial may help maintain LV/RV geometry to help optimize the RV post LVAD   Surgical considerations for LVAD candidacy  Small, hypertrophied LV: HM3 inflow cannula is small, but small hypertrophied ventricles tend towards chamber collapse during systole causing suction, needing to run slower with lower flow rates  Chest size/diameter: pumps have gotten so small now, that for adults, these have become less of a consideration  BMI: low BMI used to be more of a concern with the older pumps due to where they were placed, and the relative size of the pump itself, not so much now with the smaller HM 3 pumps  Calcified LV apex: would increase risk of stroke, bleeding   Driveline tunneling becomes a concern in the super obese population, higher risk for driveline infections (might tunnel these driveline's shorter, and to a less fatty region of the abdomen, could even tunnel out the thoracic cavity in the super obese to limit skin motion)    5. Is there a role for MCS (i.e. temporary LVAD such as Impella) in pre-habilitation of patients prior to LVAD surgery?   The theory of being able to improve systemic perfusion, decongest the organs, and make the patient feel better prior to surgery makes sense, but becomes problematic due to the lack of a hard end point/time for prehabilitation which might risk delays in surgery   More likely that it can lead to delay in the surgery, with less-than-optimal benefit; you don't want to prolong the wait for surgery and increase the risk for complications prior to surgery    An Impella 5.5 is currently FDA approved for 2 weeks of support, not 2 months so timing is important to keep in mind  It’s unlikely that you will take a patient and convert them from a malnourished, cachectic person in 2 weeks’ time   6. Is there a role for LVAD therapy in the younger patient population? Should we be thinking of LVAD up front for these patients, with the goal of transplanting down the line?   Recovery may be more likely in certain populations, particularly younger females with smaller LV's; in those populations, perhaps bridge to recovery should be the focus, optimizing them on GDMT etc.   The replacement of transplant, with MCS (LVAD) in young patients has become a topic of discussion, because these pumps have become better and better, with the thinking that an LVAD could bridge a patient for 10 years or so, and they could get a transplant later   It is still a big unknown, but several concerns exist  Patients who get LVADs might end up with complications that become contraindication to transplant down the line (stroke, sensitization etc)   Patients and providers are more hesitant because of the more recent iteration for the UNOS criteria for OHT listing which no longer gives patients with an uncomplicated LVAD higher priority, and therefore they could end up waiting a longer time for a heart after undergoing LVAD  References Rose EA, Gelijns AC, Moskowitz AJ, et al. Long-term use of a left ventricular assist device for end-stage heart failure. N Engl J Med. 2001;345(20):1435-1443. doi:10.1056/NEJMoa012175  Mehra MR, Uriel N, Naka Y, et al. A Fully Magnetically Levitated Left Ventricular Assist Device – Final Report. N Engl J Med. 2019;380(17):1618-1627. doi:10.1056/NEJMoa1900486  Mancini D, Colombo PC. Left Ventricular Assist Devices: A Rapidly Evolving Alternative to Transplant. J Am Coll Cardiol. 2015;65(23):2542-2555. doi:10.1016/j.jacc.2015.04.039  Mehra MR, Goldstein DJ, Cleveland JC, et al. Five-Year Outcomes in Patients With Fully Magnetically Levitated vs Axial-Flow Left Ventricular Assist Devices in the MOMENTUM 3 Randomized Trial. JAMA. 2022;328(12):1233-1242. doi:10.1001/jama.2022.16197  Rose EA, Moskowitz AJ, Packer M, et al. The REMATCH trial: rationale, design, and end points. Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure. Ann Thorac Surg. 1999;67(3):723-730. doi:10.1016/s0003-4975(99)00042-9  Kittleson MM, Shah P, Lala A, et al. INTERMACS profiles and outcomes of ambulatory advanced heart failure patients: A report from the REVIVAL Registry. J Heart Lung Transplant. 2020;39(1):16-26. doi:10.1016/j.healun.2019.08.017  Mehra MR, Netuka I, Uriel N, et al. Aspirin and Hemocompatibility Events With a Left Ventricular Assist Device in Advanced Heart Failure: The ARIES-HM3 Randomized Clinical Trial. JAMA. 2023;330(22):2171-2181. doi:10.1001/jama.2023.23204  Mehra MR, Nayak A, Morris AA, et al. Prediction of Survival After Implantation of a Fully Magnetically Levitated Left Ventricular Assist Device. JACC Heart Fail. 2022;10(12):948-959. doi:10.1016/j.jchf.2022.08.002  Bhardwaj A, Salas de Armas IA, Bergeron A, et al. Prehabilitation Maximizing Functional Mobility in Patients With Cardiogenic Shock Supported on Axillary Impella. ASAIO J. 2024;70(8):661-666. doi:10.1097/MAT.0000000000002170