Podcasts about Frailty

What are your thoughts on Alpha-ketoglutarate for healthy aging?A treatment for warts?Am I destined to develop diabetes given my strong family history of diabetes and high blood pressure?

Consequences of weight loss with weight loss drugs...Enter myostatin inhibitor drugsMy latest HgbA1c is 5.9, and I'm doing everything right. What gives?I'm approaching 80. Could you discuss aging?

As we close out this Best of 2025, these episodes represent far more than download numbers or chart positions. They reflect the conversations that resonated most with you, the ones that challenged practice, reinforced fundamentals, and reminded us why this work matters.From Prehospital Resuscitative Thoracotomy for Traumatic Cardiac Arrest with Mike Christian, to The Evolving Nature of Major Incidents with Adam Desmond, Paediatric Assessment in Critical Care with Anna Dobbie, Frailty in Geriatric Patients with Iain Wilkinson and James Adams, and The Last Year of Life focusing on Palliative and End of Life Care; each episode speaks to a different phase of life, a different clinical challenge, and a different kind of responsibility. Together, they capture the full spectrum of pre-hospital and emergency care: from critical care decisions to thoughtful, values-based care at the end of life.They remind us that excellence in practice is not just about technical skill or clinical algorithms, but about clear communication, teamwork, and compassion, whether we are managing traumatic cardiac arrest, supporting families during major incidents, caring for critically unwell children, advocating for frail older adults, or walking alongside patients in their final year of life.Thank you for being part of our podcast community throughout 2025. Your engagement is what makes these conversations possible, and it is a privilege to continue them with you into the year ahead. Finally, thank you to PAX bags for their continued support of the podcast. You can find the best-in-class medical bags here: https://www.pax-bags.com/en/

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3233: Eric Bach makes a compelling case for strength training as the most powerful tool to extend not just lifespan but healthspan. By preserving muscle mass, boosting metabolism, and improving mobility, intelligent resistance training can help you look, feel, and move like someone decades younger, no miracle diets or gimmicks required. Read along with the original article(s) here: https://bachperformance.com/strength-training-the-ultimate-fountain-of-youth/ Quotes to ponder: "Lifting weights isn't about being jacked, ‘bro. It's about living longer and healthier, ‘bro." "Getting stronger in the gym is the compound interest of training. The more you put in earlier, the more wealth you'll accumulate over time." "Building a foundation of strength improves your ability to build muscle." Episode references: Frailty and adverse health outcomes study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2465752/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3233: Eric Bach makes a compelling case for strength training as the most powerful tool to extend not just lifespan but healthspan. By preserving muscle mass, boosting metabolism, and improving mobility, intelligent resistance training can help you look, feel, and move like someone decades younger, no miracle diets or gimmicks required. Read along with the original article(s) here: https://bachperformance.com/strength-training-the-ultimate-fountain-of-youth/ Quotes to ponder: "Lifting weights isn't about being jacked, ‘bro. It's about living longer and healthier, ‘bro." "Getting stronger in the gym is the compound interest of training. The more you put in earlier, the more wealth you'll accumulate over time." "Building a foundation of strength improves your ability to build muscle." Episode references: Frailty and adverse health outcomes study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2465752/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Popular media leverage weak study to criticize RFK Jr.'s rethink of standard recommendations for saturated fat avoidance; Poor quality plant-based diets hike cardio risk; A listener complains his lp(a) is going up with age despite his healthy diet, lifestyle; Scientists pinpoint cocoa ingredient that slows aging; Berry proanthocyanidins preserve brain power; Tattooing may promote inflammation, undermine immunity.

In the 200th episode of Health & Veritas, Harlan offers end-of-the-year reflections on medicine drawn from his editor's notes in JACC (the Journal of the American College of Cardiology), and Howie provides updates on gun violence, flu, measles, and the health benefits of yoga. Show notes: Editor's notes by Harlan Krumholz "The Day I Became a Doctor" "When Your Patient Dies" "Rethinking Physician Certification: A Call for a Modern, Meaningful Standard" Gun violence, flu, and measles "Mass shootings outnumber annual days in U.S., children are missing school due to measles, Covid-19 is peeping around the corner, and some hope" "Measles outbreaks worsen in South Carolina, Arizona and Utah" "Connecticut reports first measles case in years" "New Flu Variant May Be Triggering Spike in Severe Disease" "High-Dose Influenza Vaccine Effectiveness against Hospitalization in Older Adults" "Pfizer Reaffirms Full-Year 2025 EPS Guidance and Provides Full-Year 2026 Guidance" The benefits of yoga "Yoga for chronic non‐specific low back pain" "Yoga-based interventions may reduce anxiety symptoms in anxiety disorders and depression symptoms in depressive disorders: a systematic review with meta-analysis and meta-regression" "Effect of Yoga on Frailty in Older Adults" "Yoga in autoimmune disorders: a systematic review of randomized controlled trials" "Long-term effects of yoga-based practices on neural, cognitive, psychological, and physiological outcomes in adults: a scoping review and evidence map" "Yoga isn't just for flexibility. It may also protect brain health." In the Yale School of Management's MBA for Executives program, you'll get a full MBA education in 22 months while applying new skills to your organization in real time. Yale's Executive Master of Public Health offers a rigorous public health education for working professionals, with the flexibility of evening online classes alongside three on-campus trainings. Email Howie and Harlan comments or questions.

In this episode of GEMCast, host Dr. Christina Shenvi is joined by Dr. James Van Oppen, emergency physician and frailty expert at the University of Sheffield, to discuss the rising importance of frailty in emergency medicine. Frailty, defined as the loss of physiological resilience, is both common and clinically significant for older adults presenting to the emergency department (ED). The two discuss what frailty means, how it can be identified, and how to approach ED assessment and management in a frail patient, emphasizing the value of person-centred care. Furthermore, they highlight recent studies regarding frailty, which can be found in the resources below, and discuss the need for system-wide changes to support frailty care. Alongside his work as an emergency physician and clinical lecturer, Dr. van Oppen is the chair of the geriatric emergency medicine section of the European Society of Emergency Medicine. Tune in to this episode to expand your understanding of frailty and hear some practical tips to improve your clinical practice.

In the 200th episode of Health & Veritas, Harlan offers end-of-the-year reflections on medicine drawn from his editor's notes in JACC (the Journal of the American College of Cardiology), and Howie provides updates on gun violence, flu, measles, and the health benefits of yoga. Show notes: Editor's notes by Harlan Krumholz "The Day I Became a Doctor" "When Your Patient Dies" "Rethinking Physician Certification: A Call for a Modern, Meaningful Standard" Gun violence, flu, and measles "Mass shootings outnumber annual days in U.S., children are missing school due to measles, Covid-19 is peeping around the corner, and some hope" "Measles outbreaks worsen in South Carolina, Arizona and Utah" "Connecticut reports first measles case in years" "New Flu Variant May Be Triggering Spike in Severe Disease" "High-Dose Influenza Vaccine Effectiveness against Hospitalization in Older Adults" "Pfizer Reaffirms Full-Year 2025 EPS Guidance and Provides Full-Year 2026 Guidance" The benefits of yoga "Yoga for chronic non‐specific low back pain" "Yoga-based interventions may reduce anxiety symptoms in anxiety disorders and depression symptoms in depressive disorders: a systematic review with meta-analysis and meta-regression" "Effect of Yoga on Frailty in Older Adults" "Yoga in autoimmune disorders: a systematic review of randomized controlled trials" "Long-term effects of yoga-based practices on neural, cognitive, psychological, and physiological outcomes in adults: a scoping review and evidence map" "Yoga isn't just for flexibility. It may also protect brain health." In the Yale School of Management's MBA for Executives program, you'll get a full MBA education in 22 months while applying new skills to your organization in real time. Yale's Executive Master of Public Health offers a rigorous public health education for working professionals, with the flexibility of evening online classes alongside three on-campus trainings. Email Howie and Harlan comments or questions.

First shots fired in war against ultra-processed foods; What the big reveal of Trump's MRI really shows; Is cruelty to horses really necessary to make estrogen? Early smartphone use linked to mental harms in kids; Nutritionist sues American Diabetes Association for forcing her to promote unhealthy artificial sweeteners; Halle Berry dings California Governor Newsom for vetoing menopause awareness bill.

Nutritionist Leyla Muedin details a study on the effects of vitamins C and E supplementation in older women with sarcopenia. The study, published in the journal Medicine, found that combining 1000 mg of vitamin C and 335 mg of vitamin E with a 12-week resistance training program significantly improved muscle mass, strength, and certain blood parameters compared to a placebo group. The benefits were attributed to the alleviation of oxidative stress and inflammation. Leyla underscores the importance of adequate animal protein intake to optimize resistance training outcomes.

In the past on this podcast, we have often asked the question of whether a monster is born or are they made? This might be the episode that finally answers that question. The story that follows suggests that monsters are NOT born; they're made – often by the very people who should protect them.Have a question or comment? Text us on the Haunt Line @ 217-791-7859New Facebook page - https://www.facebook.com/troytaylorodditiesCheck out our updated website and sign up for our newsletter at AmericanHauntingsPodcast.comWant an episode every week, plus other awesome perks and discounts? Check out our Patreon pageFind out merch at AmericanHauntingsClothing.comFollow us on Twitter @AmerHauntsPod, @TroyTaylor13, @CodyBeckSTLFollow us on Instagram @AmericanHauntingsPodcast, @TroyTaylorgram, @CodyBeckSTLThis episode was written by Troy TaylorProduced and edited by Cody BeckOur Sponsors:* Check out CBDfx and use my code HAUNTINGS for a great deal: https://cbdfx.com* Check out Shopify: https://shopify.com/hauntings* Check out Uncommon Goods: https://uncommongoods.com/HAUNTINGSSupport this podcast at — https://redcircle.com/american-hauntings-podcast/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

No Soul Is Safe. "Giving Thanks Month" continues! A whole month of Patron-picked movies! Next up is Bill Paxton's 2001 directorial debut FRAILTY from longtime patron "James B"! In an FBI office, a man recounts a disturbing childhood tied to his father's divine mission to destroy evil. As his story unfolds, the present and past collide. Also this week: Traffic woes, Meatballs franchise trivia, and tryting to remember who the heck is in Tombstone? All this--and a whole lot more--on this week's episode of NEON BRAINIACS!! "Only demons should fear me... You're not a demon, are you?" ----- Check out our Patreon for tons of bonus content, exclusive goodies, and access to our Discord server! ----- Frailty (2001) Directed by Bill Paxton Written by Brent Hanley Starring Bill Paxton, Matthew McConaughey, Powers Boothe, Matt O'Leary, Jeremy Sumpter, Derk Cheetwood, and Missy Crider ----- 00:00 - Intro & Opening Banter 37:11 - "The Shpiel" 01:00:11 - Film Breakdown 01:51:25 - Stump The Brainiac & Outro

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

We're tantalizing ALL of your senses with our newest theme – RAW and Un-SENSE-ored: Horror Movies about the Senses – brought to you by Lucas! His first pick… maybe stretches the boundaries of the horror realm but we have a good time anyway tickling our olfactories with a discussion on PERFUME: STORY OF A MURDERER!   Go to patreon.com/SHUDcast where you can sign up for all kinds of extra goodies! 00:00 - 9:40ish -  Intros: Lucas went on an odyssey, Tron: Ares, Good Morning America   9:40ish - 1:08:00ish - The other stuff we watched this time!   Lucas - Skinamarink, Christmas Bloody Christmas, One Battle After Another, Perfect Neighbor, LOTR: The Two Towers, Uncut Gems   Cody - One Battle After Another, Sleepy Hollow, Primate, Exhuma, Here for Blood, Night of the Reaper, Bone Lake, Dust Bunny, Deathstalker, Death of a Unicorn, Frankenweenie, This Night I'll Possess Your Corpse, The Devil's Rejects, The Strange World of Coffin Joe, A Nightmare Before Christmas, Freaked!, Scream, Blink, Cape Fear, Ouija: Origin of Evil   Austin - Primate, Dust Bunny, Deathstalker, 28 Years Later, The Boy Behind the Door, Black Phone 2, K-Pop Demon Hunters, Presence, VHS Halloween, The Monkey, Sinners   Curtis - One Battle After Another, Primate, Dust Bunny, Deathstalker, Black Phone 2, Presence, VHS Halloween, No Other Choice, Chungking Express, The Furious, A Bittersweet Life, Pumpkinhead, At the Drive-In, Gonjiam: Haunted Asylum, Ernest Scared Stupid, Cronos, The Devil's Backbone, Mimic, 10 Cloverfield Lane, Lake Mungo, The Descent, Frailty, The Texas Chain Saw Massacre   1:08:00ish - 1:42:00ish - PERFUME: THE STORY OF A MURDERER - SHUDdown and discussion!   1:42:00ish - End - Movie #2 of “Raw and Un-SENSE-ored: Horror Movies about the Senses” brought to you by Lucas!

Welcome to Day 2730 of Wisdom-Trek. Thank you for joining me. This is Guthrie Chamberlain, Your Guide to Wisdom Day 2760 – Wisdom Nuggets – Psalm 90:10-17 – Daily Wisdom Wisdom-Trek Podcast Script - Day 2730 Welcome to Wisdom-Trek with Gramps! I am Guthrie Chamberlain, and we are on Day 2730 of our Trek. The Purpose of Wisdom-Trek is to create a legacy of wisdom, to seek out discernment and insights, and to boldly grow where few have chosen to grow before. The title of today's Wisdom-Trek is: The Wisdom to Number Our Days – A Prayer for Satisfaction and Significance Today, we reach the conclusion of the oldest psalm in the Psalter, Psalm Ninety, also known as the timeless Prayer of Moses, covering its remaining verses, ten through seventeen, in the New Living Translation. In our last conversation, we explored the sobering first half of this psalm. Moses established the immense chasm between the eternal God—our “home” and refuge who predates the mountains—and the transient life of man, who vanishes like a “dream” or “grass” that is withered by evening. We acknowledged that our fleeting years are often spent under the cloud of God's righteous anger against sin, as He sets our “secret sins in the light of [His] presence” (Psalm Ninety, verse eight). Now, Moses moves from somber theological reflection to a fervent, practical prayer. Recognizing the brevity and the sorrow of a life lived under divine displeasure, he prays for wisdom, mercy, and ultimate significance. This concluding segment is the mature response to our mortality: since our days are numbered, how can we ensure they are counted for something eternal? So, let us open our hearts to this ancient and vital prayer, learning how to redeem the time God has given us. The first segment is: The Frailty of Life and the Plea for Wisdom Psalm Ninety: verses ten through twelve Seventy years are given to us! Some even live to eighty. But even the best years are filled with pain and trouble; soon they disappear, and we fly away. Who can comprehend the power of your anger? Your wrath is as awesome as the fear you deserve. Teach us to realize the brevity of life, so that we may grow in wisdom. Moses begins by stating the typical limit of human lifespan, a stark number based on his long experience with the dying generation in the wilderness: "Seventy years are given to us! Some even live to eighty." This lifespan, while a gift, is often limited, but Moses acknowledges that longer life isn't always better: "But even the best years are filled with pain and trouble; soon they disappear, and we fly away." This speaks to a universal truth: even the healthiest and most prosperous years have their share of hardship—a reality that the ancient Israelites knew...

Frailty, once thought to be irreversible, is now recognized as a condition that can be improved through consistent outdoor movement, restoring strength, balance, and independence in older adults Research from Canada's GO-OUT studies shows that even simple walking programs — whether guided park walks or weekly reminders — measurably reduce frailty and boost mobility in as little as 10 weeks Confidence, not just time spent walking, proved to be the strongest predictor of improvement, as older adults who practiced in supportive outdoor groups felt safer and more capable continuing on their own A Hong Kong trial found that pairing a smartphone app with outdoor fitness equipment helped older adults stay active, build exercise confidence, and improve mental well-being far beyond structured classes You don't need a gym to rebuild vitality — start with short, daily walks outdoors, add small balance or strength challenges, and work toward one hour a day to strengthen muscles, circulation, and confidence naturally

Dr Mian discussed why frailty should be understood as a dynamic, evolving clinical state rather than a fixed baseline characteristic

This episode covers: Cardiology this Week: A concise summary of recent studies Lp(a) - What to expect in the very near future Myocardial infarction in older and frail adults Mythbusters: is beetroot good for your heart? Host: Rick Grobbee Guests: JP Carpenter, Vijay Kunadian, Erik Stroes Want to watch that episode? Go to: https://esc365.escardio.org/event/2177 Want to watch that extended interview on Lp(a), go to: https://esc365.escardio.org/event/2177?resource=interview   Disclaimer  ESC TV Today is supported by Bristol Myers Squibb and Novartis through an independent funding. The programme has not been influenced in any way by its funding partners. This programme is intended for health care professionals only and is to be used for educational purposes. The European Society of Cardiology (ESC) does not aim to promote medicinal products nor devices. Any views or opinions expressed are the presenters' own and do not reflect the views of the ESC. The ESC is not liable for any translated content of this video. The English language always prevails.    Declarations of interests Stephan Achenbach, Yasmina Bououdina, Rick Grobbee, Nicolle Kraenkel, Vijay Kunadian and Erik Stroes have declared to have no potential conflicts of interest to report. Carlos Aguiar has declared to have potential conflicts of interest to report: personal fees for consultancy and/or speaker fees from Abbott, AbbVie, Alnylam, Amgen, AstraZeneca, Bayer, BiAL, Boehringer-Ingelheim, Daiichi-Sankyo, Ferrer, Gilead, GSK, Lilly, Novartis, Pfizer, Sanofi, Servier, Takeda, Tecnimede. John-Paul Carpenter has declared to have potential conflicts of interest to report: stockholder MyCardium AI. Davide Capodanno has declared to have potential conflicts of interest to report: Bristol Myers Squibb, Daiichi Sankyo, Sanofi Aventis, Novo Nordisk, Terumo. Konstantinos Koskinas has declared to have potential conflicts of interest to report: honoraria from MSD, Daiichi Sankyo, Sanofi. Steffen Petersen has declared to have potential conflicts of interest to report: consultancy for Circle Cardiovascular Imaging Inc. Calgary, Alberta, Canada. Emma Svennberg has declared to have potential conflicts of interest to report: Abbott, Astra Zeneca, Bayer, Bristol-Myers, Squibb-Pfizer, Johnson & Johnson.

In the quiet corridors of a seaside care home, on an ordinary weekday afternoon, a 92-year-old man sat confused in his wheelchair, gripping a butter knife he'd been using to eat his lunch. Within minutes, two police officers would arrive at his door after being alerted that it was vital for them to attend the scene quickly, as someone's life had been threatened…*** LISTENER CAUTION IS ADVISED *** This episode was researched and written by Eileen Macfarlane.Edited by Joel Porter at Dot Dot Dot Productions.Script editing, additional writing, illustrations and production direction by Rosanna FittonNarration, additional audio editing and mixing, and script editing by Benjamin Fitton.To get early ad-free access, including Season 1, sign up for They Walk Among PLUS, available from Patreon or Apple Podcasts.More information and episode references can be found on our website https://theywalkamonguspodcast.comMUSIC: Falling Skies by Louis Lion Darker Days by Alternate Endings Pursuit Of Wonder by Caleb Etheridge Road To Nowhere by Caleb Etheridge To What End by Caleb Etheridge Rampant by CJ0 Bane by Cody Martin Far From Home by Cody Martin Final Moments by Cody Martin Outer Rim by Cody Martin Rising Sun by Colossus Distant Water by Chelsea McGough Siege by Hill Creeper by Hill The Plot Thickens by Joshua Spacht Ancient Ground by Moments The Way Back by Moments Onward by Chelsea McGough SOCIAL MEDIA: https://linktr.ee/TheyWalkAmongUsSupport this show http://supporter.acast.com/theywalkamongus. Hosted on Acast. See acast.com/privacy for more information.

Ab 60 Jahren in die Muckibude? Häufiger ein Frühstücksei im Alter? Zurückhaltung bei der Blutdruckregulation? Persönlich wie auch fachlich besprechen Markus M. Lerch und Cornel Sieber die Besonderheiten bei Prävention und Therapien im Alter. Und was es eigentlich bedeutet, gebrechlich – also frail – zu sein.

Commentary by Dr. Mert Kaskal.

Commentary by Dr. Xin Zhou.

Blastober barrels forth with 2001's creepy psychological horror FRAILTY! FRAILTYDIRECTED BY: Bill PaxtonRELEASED: April 12, 2002STARRING: Bill Paxton, Matthew McConaughey, Powers Boothe, Luke Askew, Jeremy Sumpter BUDGET: $11mBOX OFFICE: $17,4mESTIMATED LOSS: $2mNEXT EPISODE: We wrap up Blastober with the third and final feature from a Master of Horror. SHOW NOTESAuto shop angelhttps://imgur.com/a/6Q7J43sScenes of Meat, TXhttps://imgur.com/a/g1kxxFn0:00 Intro 3:45 Show & tell8:30 This week's movie

Jade Greenfield • Psalm 77:1–77:20 • Steadfast

Jade Greenfield • Psalm 77:1–77:20

Welcome to The B-Side! Here we talk about movie stars! Not the movies that made them famous or kept them famous, but the ones that they made in between. Today we talk about a performer that we lost far too soon: Bill Paxton. Our B-Sides today include Brain Dead, Indian Summer, Traveller, and Frailty. Our guest is Billy Ray Brewton, and we cover a lot of ground. We dive into Paxton's Roger Corman origins (Crazy Mama getting reamed out by legend Stella Adler in New York, his ultimate move to Los Angeles, James Cameron, etc.), his love of movie-making and being on set, his tragic death, and much, much more. We mention his first directing gig (“Fish Heads” by Barnes & Barnes on SNL), his last directed feature (The Greatest Game Ever Played), and his recent podcast appearances before his death. There is also this charming late night appearance.

Targeting the biology of aging offers a path to stronger resilience and longer health. John C. Newman, M.D., Ph.D., explains that aging arises from measurable cellular processes, often called hallmarks of aging, including changes involving mitochondria, stem cells, cellular senescence, inflammation, and protein quality control. Newman describes how basic science in model organisms reveals mechanisms that can be manipulated to extend healthy lifespan and guide therapies. Emerging approaches aim either to strengthen stress responses that make cells more resilient or to address downstream consequences. Many clinical studies across the country now test interventions that target aging, supported by national efforts to standardize methods and expand training. Newman also investigates ketone bodies as energy sources that influence inflammation, muscle preservation, and other processes relevant to frailty and recovery. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40961]

Targeting the biology of aging offers a path to stronger resilience and longer health. John C. Newman, M.D., Ph.D., explains that aging arises from measurable cellular processes, often called hallmarks of aging, including changes involving mitochondria, stem cells, cellular senescence, inflammation, and protein quality control. Newman describes how basic science in model organisms reveals mechanisms that can be manipulated to extend healthy lifespan and guide therapies. Emerging approaches aim either to strengthen stress responses that make cells more resilient or to address downstream consequences. Many clinical studies across the country now test interventions that target aging, supported by national efforts to standardize methods and expand training. Newman also investigates ketone bodies as energy sources that influence inflammation, muscle preservation, and other processes relevant to frailty and recovery. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40961]

Targeting the biology of aging offers a path to stronger resilience and longer health. John C. Newman, M.D., Ph.D., explains that aging arises from measurable cellular processes, often called hallmarks of aging, including changes involving mitochondria, stem cells, cellular senescence, inflammation, and protein quality control. Newman describes how basic science in model organisms reveals mechanisms that can be manipulated to extend healthy lifespan and guide therapies. Emerging approaches aim either to strengthen stress responses that make cells more resilient or to address downstream consequences. Many clinical studies across the country now test interventions that target aging, supported by national efforts to standardize methods and expand training. Newman also investigates ketone bodies as energy sources that influence inflammation, muscle preservation, and other processes relevant to frailty and recovery. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40961]

Targeting the biology of aging offers a path to stronger resilience and longer health. John C. Newman, M.D., Ph.D., explains that aging arises from measurable cellular processes, often called hallmarks of aging, including changes involving mitochondria, stem cells, cellular senescence, inflammation, and protein quality control. Newman describes how basic science in model organisms reveals mechanisms that can be manipulated to extend healthy lifespan and guide therapies. Emerging approaches aim either to strengthen stress responses that make cells more resilient or to address downstream consequences. Many clinical studies across the country now test interventions that target aging, supported by national efforts to standardize methods and expand training. Newman also investigates ketone bodies as energy sources that influence inflammation, muscle preservation, and other processes relevant to frailty and recovery. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40961]

Targeting the biology of aging offers a path to stronger resilience and longer health. John C. Newman, M.D., Ph.D., explains that aging arises from measurable cellular processes, often called hallmarks of aging, including changes involving mitochondria, stem cells, cellular senescence, inflammation, and protein quality control. Newman describes how basic science in model organisms reveals mechanisms that can be manipulated to extend healthy lifespan and guide therapies. Emerging approaches aim either to strengthen stress responses that make cells more resilient or to address downstream consequences. Many clinical studies across the country now test interventions that target aging, supported by national efforts to standardize methods and expand training. Newman also investigates ketone bodies as energy sources that influence inflammation, muscle preservation, and other processes relevant to frailty and recovery. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40961]

BUFFALO, NY — October 14, 2025 — A new #research paper was #published in Volume 17, Issue 9 of Aging-US on August 30, 2025, titled, “Glycocalyx-targeted therapy prevents age-related muscle loss and declines in maximal exercise capacity.” In this study, led by Daniel R. Machin from the University of New Mexico School of Medicine and the University of Utah, researchers found that protecting a fragile layer lining blood vessels, known as the glycocalyx, can prevent muscle deterioration and help maintain physical performance during aging. They also discovered that a supplement containing high-molecular-weight hyaluronan (HMW-HA), a key component of the glycocalyx, enabled older mice to preserve muscle mass and exercise capacity. These findings suggest that targeting the glycocalyx may offer a new approach to reduce frailty and support mobility in older adults. As this layer degrades with age, it contributes to cardiovascular and muscular decline by impairing blood flow and vascular health. The study examined how preserving the glycocalyx using a therapy called Endocalyx™ affects physical function in aging mice. Researchers first studied genetically modified mice lacking Has2, the enzyme responsible for producing HMW-HA. These mice had a thinner glycocalyx, reduced exercise performance, and lower mitochondrial function in their muscles, even though muscle size remained normal. This indicated that glycocalyx damage alone can directly impair physical performance. The team then gave older mice a diet containing Endocalyx™ for 10 weeks. Compared to untreated controls, these mice maintained muscle mass and performed better on treadmill tests. Notably, the treated mice did not show the typical age-related decline in muscle strength and endurance. While the supplement did not fully restore youthful performance, it significantly slowed physical deterioration, suggesting a protective benefit. In contrast, untreated older mice lost both body mass and muscle volume during the same period. “Taken together, these findings provide direct evidence of a role for HMW-HA in the modulation of exercise capacity.” This research builds on prior evidence that the glycocalyx is essential for healthy blood vessel function. Since muscle health depends on proper blood flow and oxygen delivery, restoring the glycocalyx may help maintain strength and mobility with age. While more research is needed to confirm these results in humans, the findings point to a potential therapeutic approach to promote healthier aging. DOI - https://doi.org/10.18632/aging.206313 Corresponding author - Daniel R. Machin — dmachin@salud.unm.edu Abstract video - https://www.youtube.com/watch?v=S7HjCeXT8fU Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206313 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, glycocalyx, hyaluronan To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

I. Pastoral Humility. II. Pastoral Integrity. III. Pastoral Proximity.

Think strength training is just about building muscle? Think again. Your workouts activate myokines that positively influence nearly every organ in your body. In this episode, Amy Hudson and Dr. James Fisher break down the world of myokines--the powerful messengers released during exercise that can fight disease, sharpen your brain, and even slow aging. Expect to learn how strength training floods your body with health-boosting signals, why myokines are called “magic,” and ways strength protects both your lifespan and healthspan. Tune in to discover why muscle is the most underrated organ in your body—and how to tap into its hidden power. Dr. Fisher starts by describing why we need to think of muscle differently: It's not just tissue that moves your body, it's a chemical messenger system that sends positive signals all over the body.  Amy and Dr. Fisher cover why exercise is medicine. Each contraction releases myokines that calm inflammation, boost immunity, and even protect against cancer and neurological decline.  For decades, scientists knew muscles released “something,” but the name myokines wasn't coined until 2003. Now we know muscles are the largest endocrine organ in our bodies. Dr. Fisher explains the endocrine connection: Your muscles talk to organs the way your thyroid or pancreas does, constantly sending and receiving instructions.  According to Amy, you don't need six months of training before myokines start working. Just one resistance session floods your body with signals that improve energy, mood, and metabolism. How to fight belly fat naturally. According to Dr. Fisher, a myokine called interleukin-15 literally shrinks fat cells, making them store less. At the same time, it activates immune cells that protect you against tumors and infections. Amy compares myokines to magic. Science shows that training creates chemical changes that feel almost supernatural. The “magic” is your body healing itself from the inside out. Learn how exercise boosts your brain: Myokines like BDNF (Brain-Derived Neurotrophic Factor) act like fertilizer for your brain cells. They help you think sharper, learn faster, and protect against cognitive decline. Dr. Fisher explains why muscle growth isn't accidental. There's a molecule called myostatin that tries to limit your muscle growth. Resistance training shuts it down—so your muscles can grow instead of being held back. Amy explains the anti-aging effects of strength training.  Dr. Fisher highlights the consequences of aging without strength: Frailty, injuries, and dependence. Building strength is the single best insurance policy against that future. According to Amy, life is not about how long you live—it's about how long you can thrive. Myokines help you extend the years you can stay active, engaged, and vibrant. Amy and Dr. Fisher discuss how every squat, push, or pull unlocks healing compounds you can't get from a pill.  Amy's parting thoughts: Your body is wired to reward strength, that's why each workout delivers an immediate chemical payoff that makes you feel good.     Mentioned in This Episode: The Exercise Coach - Get 2 Free Sessions! Submit your questions at StrengthChangesEverything.com     This podcast and blog are provided to you for entertainment and informational purposes only. By accessing either, you agree that neither constitute medical advice nor should they be substituted for professional medical advice or care. Use of this podcast or blog to treat any medical condition is strictly prohibited. Consult your physician for any medical condition you may be having. In no event will any podcast or blog hosts, guests, or contributors, Exercise Coach USA, LLC, Gymbot LLC, any subsidiaries or affiliates of same, or any of their respective directors, officers, employees, or agents, be responsible for any injury, loss, or damage to you or others due to any podcast or blog content.

  WITH AN AXE!!!

BUFFALO, NY — October 3, 2025 — A new #research perspective was #published in Volume 17, Issue 9 of Aging-US on August 26, 2025, titled “Analysis of the current state of frailty indexes and their implementation for aging intervention studies.” In this work, led by first author Oliver G. Frost from Loughborough University alongside corresponding authors Abdelhadi Rebbaa and Amit Sharma, from the Lifespan Research Institute, the authors explore growing concerns about the lack of standardization in how frailty is measured in rodent aging studies, which may limit the development of effective interventions targeting age-related decline. Frailty, a key indicator of deteriorating health in older adults, is increasingly assessed in preclinical models using frailty indexes (FIs). These indexes quantify health deficits, such as reduced mobility, cognitive decline, or physical weakness. However, this perspective highlights that FI methodologies vary significantly across studies, from the selection of parameters to the cut-off thresholds used, resulting in inconsistent outcomes that affects reproducibility and translational value. The authors reviewed 18 rodent studies and found substantial variation in how frailty is defined and measured. Some FIs rely on clinical observations, such as appearance or beahaviour, while others focus on physical performance metrics like grip strength or locomotion. In several cases, applying different FIs to the same group of animals produced contradictory results, underscoring the importance of harmonized protocols. To illustrate these issues, the researchers applied an 8-item FI to mice of different ages and found that even young mice were sometimes scored as frail, depending on the scoring method and reference values. This finding emphasizes the need for consistent baselines and controlled environments, especially when comparing across studies. The authors recommend using each animal as its own baseline in longitudinal studies, a strategy that enhances reliability without adding significant cost. “Sex as a biological variable in FIs is an important consideration, as there is a known difference between male and female frailty onset and progression.” The authors also discuss emerging automated tools, such as video-based open-field testing, which can reduce observer bias and improve reproducibility. In the future, broader health indicators, such as cognition, circadian rhythms, social behavior, and body composition, may further enhance frailty assessments. Overall, this work underscores the urgent need for standardized, transparent, and reproducible methods for evaluating frailty in preclinical aging studies. Improved consistency in frailty scoring will better inform the development of healthspan-extending therapies and enhance the translational relevance of animal models. DOI - https://doi.org/10.18632/aging.206307 Corresponding authors - Abdelhadi Rebbaa - rebbaa@gmail.com, and Amit Sharma - amit.sharma@sens.org Abstract video - https://www.youtube.com/watch?v=eha3XA9LyWA Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206307 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, frailty, rodents, frailty index, phenotype To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

"Gain muscle mass and you will live longer.” ~ Dr. Jeff Gross. Dr Gross opens this episode with a simple truth backed by decades of clinical insight. Strategic exercise adds muscle, builds bone density, and prevents frailty. No marathon workouts required. In this conversation we unpack his weekly routine... short intervals, and one set to failure strength work. And then we explore how natural killer cell exosomes may support immune surveillance against cancer and zombie cells while protecting healthy tissue.

Join host Alex Crespo, MD as he chats with author Michael Weaver, MD about the Journal of Orthopaedic Trauma article on the Frailty Index as a possible stratification tool in the CMS hip fracture bundle. To access the abstract, click here. For additional educational resources visit OTA.org

This week we watched the 2001 psychological horror film Frailty. Directed by Bill Paxton, in his directorial debut, the plot focuses on the strange relationship between two young brothers and their father who believes that he has been commanded by God to destroy demons disguised as people. The film stars Paxton, Matthew McConaughey and Powers Boothe. Come join us!!! Website : https://tortelliniatnoon.com/ Instagram: https://www.instagram.com/tortelliniatnoonpodcast/ Facebook: https://www.facebook.com/TortelliniAtNoon Twitter: https://twitter.com/PastaMoviePod

Just read the latest from NEJM? The PIpELINe Trial

Send us a textThe better than Van Helsing boys have spent their lives under the strict rule of their producer. Unaware of his dark past, they struggle to understand his increasingly erratic behavior. But when they begin to uncover the violent truths behind his mixing board, their world unravels, forcing them to confront having to produce the show without him. On Episode 683 of Trick or Treat Radio we discuss the film Abraham's Boys: A Dracula Story based on the short story from Joe Hill and directed by Natasha Kermani! We also talk about the upcoming Deathstalker film, isolationism and gaslighting from those you trust, and plenty of Dracula lore. So grab your monster hunting handbook, subvert any and all expectations, and strap on for the world's most dangerous podcast!Stuff we talk about: Steven Kostanski, The Void, Psycho Goreman, Frankie Freako, Deathstalker, Astron-6, practical FX, violence, sword and sorcery films, Jerry “The King” Lawler, f*ck WWE, The Incubus, Needful Things, the 13th Warrior, Eaters of the Dead, House of 1000 Corpses, Hunt for the Blood Orchid, Suspect Zero, Lets Scare Jessica to Death, The Last Exorcism, The Candyman, Watchmen, this day in horror history, Alexa Vega, bloody birthdays, The Tomorrow People, Machete Kills, Mothers Day, Psycho III, Zodiac, John Kassir, Rock and Shock, The Three Stooges, Benny and Joon, Will and Grace, Caveman, Todd Browning's Freaks, Rocket Ship XM, Invaders from Mars, Slash, Tim Seeley, Red Sonja, Rose McGowan, Deathwatch, The Dreadites, boomsword, Lucio Fulci, Conquest, covering the lens in vaseline, Sabrina Siana, Planet of the Gapes, Joe Hill, Abraham's Boys, Natasha Kermani, Titus Welliver, Jocelin Donahue, Frailty, Bill Paxton, PCU, Dogtooth, Yorgos Lanthimos, “the severed heads looked really good”, no style nor substance, Vanhelsing, movie of the week, “It's Better than Vanhelsing”, Batman, Monster: The Ed Gein Story, Wisconsin represents, Menendez Brothers, Brute 1976, Joe Knetter, Marcel Walz, Frute Brute, Countess Caramella, Brute 1976, Brut By Faberge, Mammoth, Robert Rodriguez, Greg Nicotero, Michael Jackson, Wolfgang Van Halen, Peter's Polar Bear Paradox, The Serial Killer Lookbook, Conquest and Divide, and The Ballad of Oswalt Patton.Support us on Patreon: https://www.patreon.com/trickortreatradioJoin our Discord Community: discord.trickortreatradio.comSend Email/Voicemail: mailto:podcast@trickortreatradio.comVisit our website: http://trickortreatradio.comStart your own podcast: https://www.buzzsprout.com/?referrer_id=386Use our Amazon link: http://amzn.to/2CTdZzKFB Group: http://www.facebook.com/groups/trickortreatradioTwitter: http://twitter.com/TrickTreatRadioFacebook: http://facebook.com/TrickOrTreatRadioYouTube: http://youtube.com/TrickOrTreatRadioInstagram: http://instagram.com/TrickorTreatRadioSupport the show

Feel like your midlife body has betrayed you? Stiffer joints, mysterious aches, less energy—these aren't just inconveniences, they're warning signals about your future independence. Dr. Vonda Wright, orthopedic surgeon, and author of "Unbreakable," returns to the show with a science-backed blueprint to prevent the broken hips, osteoporosis, and frailty plaguing too many women. As the country's leading voice on menopause's musculoskeletal impacts, she reveals why 70% of women experience debilitating joint pain and muscle loss. Plus, what are the six "time bombs" of aging you can control? How does your "unbreakable score" predict independence at 90? Why is muscle your literal longevity factory? Get the tools to stay strong, mobile, and unbreakable for decades ahead, beauties! FOLLOW A CERTAIN AGE: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠LinkedIn⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ GET INBOX INSPO: Sign up for our newsletter ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠AGE BOLDLY⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ We share new episodes, giveaways, links we love, and midlife resources Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Hoffman continues his conversation with Dr. Robert Silverman, author of "Immune Reboot: Maximizing Immunity, Restoring Gut Health, and Optimizing Vitality."

Dr. Robert Silverman, author of "Immune Reboot: Maximizing Immunity, Restoring Gut Health, and Optimizing Vitality," provides a comprehensive primer on the immune system. He explains how lifestyle factors—diet, sleep, exercise, and stress—impact immune resilience. He offers specific protocols for optimizing resistance to Covid, what to do if you come down with it, and how to treat Long Covid, as well as how to prepare for vaccines. 

On this episode, Aaron and Derek tackle 2001's psychological horror film "Frailty" directed by and starring Bill Paxton. They talk about Bill Paxton's creepy earnestness, how the writing cleverly handles multiple twists and reveals, and what makes this an effective horror movie without any jumpscares. They also get into McConaughey's proto-True Detective mannerisms, this flick's place between late 90s and aughts horror, and many other aspects of the movie. Aaron and Derek know that destroying demons is good. Support us on Patreon: https://www.patreon.com/WatchIfYouDare We are on PodBean, Apple Podcasts, Podchaser, Goodpods, Amazon Music, Spotify, iHeartRadio and CastBox. Please rate, review, subscribe, and share our show. Also, check out our Spotify Music playlist, links on our Twitter and Podbean page. Our socials are on Bluesky and Facebook and Twitter @WatchIfYouDare

It's no secret in 2025 that stronger muscles lead to longer life. If you're a woman in perimenopause, postmenopause or anything in between, this is no surprise to you. I think we are very aware of it, but let's unpack how weight lifting treats and prevents chronic diseases. Women, at any age, need stronger muscles for a longer life. Not just for aesthetics, but for functionality and independence.   My Guest: A longtime Vanity Fair contributing editor, Michael Joseph Gross has published investigative reporting, essays, and books about culture, technology, politics, religion, and business. He was raised in rural Illinois and lives in New York City.   Questions We Answer in This Episode: [00:04:31] How did this become a topic of interest to you personally?  [00:07:54] Let's connect strength training to prevention and treatment of illnesses often associated - even accepted - with aging? [00:20:17] Weight training has been shown to decrease anxiety and to have positive effects on risk of Alzheimer's or type 3 diabetes, can you explain for the listeners?  [00:26:31] How has the work of Dr. Maria Fiatarone Singh showed that weight training may reduce the risk of Alzheimer's? [00:33:13] Why is lifting heavy important? Do you worry that leading with “lift heavy” intimidates women? What did you uncover as evidence that it is never too late to start progressive strength training?   Why Strength Training? Strength training changes more than just your body—it's internal too. It's not about looking stronger—it's about being stronger. Adolescence and menopause are both times when women feel their bodies are changing without their consent. Strength training gives back a sense of control, capability, and power.   Stronger Muscles Longer Life At Any Age   Strong Youth: Peak bone mass forms in youth—strength training in adolescence builds lifelong health. A 10% increase in bone mass reduces future fracture risk by more than 50%.   Strong in Midlife: Dr. Maria Fiatarone Singh, geriatrician and professor in Sydney, Australia, found that even 90+ year-olds can gain muscle mass with high-intensity training. Weight training can treat and prevent nearly all chronic diseases.   Stronger Muscles Through Weight Lifting Treats and Prevents These Diseases: Type 2 Diabetes Heart Disease Osteoporosis Depression and Anxiety Insomnia Osteoarthritis Frailty Dementia & Alzheimer's Blood Pressure and Cholesterol Fall Risk   Periodization & Smart Strength Training: Periodization: Cycles of high effort, deloading, and rest. Women (especially Type A) tend to push too hard—leading to burnout or injury. Strength training should energize you, not exhaust you. Part of lifting heavy is lifting light. The goal: Live better, not just lift more.   Ancient Greek Lesson: The Right Time to Train Greek word kairos = the “opportune moment” for action. Good training is about doing the right thing at the right time. Don't blindly follow a plan. Train for your body today.   Connect with Michael: Michael's Website Twitter - DuttonBooks   Other Episodes You Might Like: Previous Episode - 5 Things I Would Do If I Were Tired All the Time  More Like This - What's Best Total Body or Split Routine in Menopause   Resources: Tune in to the upcoming Flipping 50 Masterclass. Don't know where to start? Book your Discovery Call with Debra.  

The tension between faith and delusion builds to a thrilling climax in FRAILTY, the Bill Paxton-directed y2k crime drama with Christian themes. Matthew McConaughey, who we recently reviewed as a cast member of 1994's ANGELS IN THE OUTFIELD, stars as a man recounting his troubled childhood as the son of a religiously-motivated murderer (Bill Paxton) to a detective (Powers Boothe) who is trying to solve the case of the God's Hand killer. This killer, who McConaughey's character Fenton believes is his own brother Adam, targets seemingly random victims who are allegedly demons in human form. According to Fenton, his brother Adam is carrying out the legacy of their father, who experienced religious psychosis that led to a series of murders carried out with an axe the man believed to be a magical weapon provided by God. Young Fenton and Adam react to their father's passion for God and murder in different ways; Adam's naive admiration for his father foils Fenton's teenage skepticism. The two boys are possibly a metaphor for the human journey of faith and doubt, a reading supported by a surprising twist revealing the true nature of God's prophecy. FRAILTY does a great job of exploring Christian themes in an edgy way that condemns blind faith while still understanding the importance of faith itself. View our full episode list and subscribe to any of our public feeds: http://boysbiblestudy.com Unlock 2+ bonus episodes per month: http://patreon.com/boysbiblestudy Subscribe to our Twitch for livestreams: http://twitch.tv/boysbiblestudy Follow us on Instagram: http://instagram.com/boysbiblestudy Follow us on Twitter: http://twitter.com/boysbiblestudy