Podcasts about Frailty

No Soul Is Safe. "Giving Thanks Month" continues! A whole month of Patron-picked movies! Next up is Bill Paxton's 2001 directorial debut FRAILTY from longtime patron "James B"! In an FBI office, a man recounts a disturbing childhood tied to his father's divine mission to destroy evil. As his story unfolds, the present and past collide. Also this week: Traffic woes, Meatballs franchise trivia, and tryting to remember who the heck is in Tombstone? All this--and a whole lot more--on this week's episode of NEON BRAINIACS!! "Only demons should fear me... You're not a demon, are you?" ----- Check out our Patreon for tons of bonus content, exclusive goodies, and access to our Discord server! ----- Frailty (2001) Directed by Bill Paxton Written by Brent Hanley Starring Bill Paxton, Matthew McConaughey, Powers Boothe, Matt O'Leary, Jeremy Sumpter, Derk Cheetwood, and Missy Crider ----- 00:00 - Intro & Opening Banter 37:11 - "The Shpiel" 01:00:11 - Film Breakdown 01:51:25 - Stump The Brainiac & Outro

We're tantalizing ALL of your senses with our newest theme – RAW and Un-SENSE-ored: Horror Movies about the Senses – brought to you by Lucas! His first pick… maybe stretches the boundaries of the horror realm but we have a good time anyway tickling our olfactories with a discussion on PERFUME: STORY OF A MURDERER!   Go to patreon.com/SHUDcast where you can sign up for all kinds of extra goodies! 00:00 - 9:40ish -  Intros: Lucas went on an odyssey, Tron: Ares, Good Morning America   9:40ish - 1:08:00ish - The other stuff we watched this time!   Lucas - Skinamarink, Christmas Bloody Christmas, One Battle After Another, Perfect Neighbor, LOTR: The Two Towers, Uncut Gems   Cody - One Battle After Another, Sleepy Hollow, Primate, Exhuma, Here for Blood, Night of the Reaper, Bone Lake, Dust Bunny, Deathstalker, Death of a Unicorn, Frankenweenie, This Night I'll Possess Your Corpse, The Devil's Rejects, The Strange World of Coffin Joe, A Nightmare Before Christmas, Freaked!, Scream, Blink, Cape Fear, Ouija: Origin of Evil   Austin - Primate, Dust Bunny, Deathstalker, 28 Years Later, The Boy Behind the Door, Black Phone 2, K-Pop Demon Hunters, Presence, VHS Halloween, The Monkey, Sinners   Curtis - One Battle After Another, Primate, Dust Bunny, Deathstalker, Black Phone 2, Presence, VHS Halloween, No Other Choice, Chungking Express, The Furious, A Bittersweet Life, Pumpkinhead, At the Drive-In, Gonjiam: Haunted Asylum, Ernest Scared Stupid, Cronos, The Devil's Backbone, Mimic, 10 Cloverfield Lane, Lake Mungo, The Descent, Frailty, The Texas Chain Saw Massacre   1:08:00ish - 1:42:00ish - PERFUME: THE STORY OF A MURDERER - SHUDdown and discussion!   1:42:00ish - End - Movie #2 of “Raw and Un-SENSE-ored: Horror Movies about the Senses” brought to you by Lucas!

Has life knocked the wind out of your faith? Are you struggling when evil seems to gain the upper hand in the life of those you love? Focus on Jesus.

Welcome to Day 2730 of Wisdom-Trek. Thank you for joining me. This is Guthrie Chamberlain, Your Guide to Wisdom Day 2760 – Wisdom Nuggets – Psalm 90:10-17 – Daily Wisdom Wisdom-Trek Podcast Script - Day 2730 Welcome to Wisdom-Trek with Gramps! I am Guthrie Chamberlain, and we are on Day 2730 of our Trek. The Purpose of Wisdom-Trek is to create a legacy of wisdom, to seek out discernment and insights, and to boldly grow where few have chosen to grow before. The title of today's Wisdom-Trek is: The Wisdom to Number Our Days – A Prayer for Satisfaction and Significance Today, we reach the conclusion of the oldest psalm in the Psalter, Psalm Ninety, also known as the timeless Prayer of Moses, covering its remaining verses, ten through seventeen, in the New Living Translation. In our last conversation, we explored the sobering first half of this psalm. Moses established the immense chasm between the eternal God—our “home” and refuge who predates the mountains—and the transient life of man, who vanishes like a “dream” or “grass” that is withered by evening. We acknowledged that our fleeting years are often spent under the cloud of God's righteous anger against sin, as He sets our “secret sins in the light of [His] presence” (Psalm Ninety, verse eight). Now, Moses moves from somber theological reflection to a fervent, practical prayer. Recognizing the brevity and the sorrow of a life lived under divine displeasure, he prays for wisdom, mercy, and ultimate significance. This concluding segment is the mature response to our mortality: since our days are numbered, how can we ensure they are counted for something eternal? So, let us open our hearts to this ancient and vital prayer, learning how to redeem the time God has given us. The first segment is: The Frailty of Life and the Plea for Wisdom Psalm Ninety: verses ten through twelve Seventy years are given to us! Some even live to eighty. But even the best years are filled with pain and trouble; soon they disappear, and we fly away. Who can comprehend the power of your anger? Your wrath is as awesome as the fear you deserve. Teach us to realize the brevity of life, so that we may grow in wisdom. Moses begins by stating the typical limit of human lifespan, a stark number based on his long experience with the dying generation in the wilderness: "Seventy years are given to us! Some even live to eighty." This lifespan, while a gift, is often limited, but Moses acknowledges that longer life isn't always better: "But even the best years are filled with pain and trouble; soon they disappear, and we fly away." This speaks to a universal truth: even the healthiest and most prosperous years have their share of hardship—a reality that the ancient Israelites knew...

Frailty, once thought to be irreversible, is now recognized as a condition that can be improved through consistent outdoor movement, restoring strength, balance, and independence in older adults Research from Canada's GO-OUT studies shows that even simple walking programs — whether guided park walks or weekly reminders — measurably reduce frailty and boost mobility in as little as 10 weeks Confidence, not just time spent walking, proved to be the strongest predictor of improvement, as older adults who practiced in supportive outdoor groups felt safer and more capable continuing on their own A Hong Kong trial found that pairing a smartphone app with outdoor fitness equipment helped older adults stay active, build exercise confidence, and improve mental well-being far beyond structured classes You don't need a gym to rebuild vitality — start with short, daily walks outdoors, add small balance or strength challenges, and work toward one hour a day to strengthen muscles, circulation, and confidence naturally

Dr Mian discussed why frailty should be understood as a dynamic, evolving clinical state rather than a fixed baseline characteristic

This episode covers: Cardiology this Week: A concise summary of recent studies Lp(a) - What to expect in the very near future Myocardial infarction in older and frail adults Mythbusters: is beetroot good for your heart? Host: Rick Grobbee Guests: JP Carpenter, Vijay Kunadian, Erik Stroes Want to watch that episode? Go to: https://esc365.escardio.org/event/2177 Want to watch that extended interview on Lp(a), go to: https://esc365.escardio.org/event/2177?resource=interview   Disclaimer  ESC TV Today is supported by Bristol Myers Squibb and Novartis through an independent funding. The programme has not been influenced in any way by its funding partners. This programme is intended for health care professionals only and is to be used for educational purposes. The European Society of Cardiology (ESC) does not aim to promote medicinal products nor devices. Any views or opinions expressed are the presenters' own and do not reflect the views of the ESC. The ESC is not liable for any translated content of this video. The English language always prevails.    Declarations of interests Stephan Achenbach, Yasmina Bououdina, Rick Grobbee, Nicolle Kraenkel, Vijay Kunadian and Erik Stroes have declared to have no potential conflicts of interest to report. Carlos Aguiar has declared to have potential conflicts of interest to report: personal fees for consultancy and/or speaker fees from Abbott, AbbVie, Alnylam, Amgen, AstraZeneca, Bayer, BiAL, Boehringer-Ingelheim, Daiichi-Sankyo, Ferrer, Gilead, GSK, Lilly, Novartis, Pfizer, Sanofi, Servier, Takeda, Tecnimede. John-Paul Carpenter has declared to have potential conflicts of interest to report: stockholder MyCardium AI. Davide Capodanno has declared to have potential conflicts of interest to report: Bristol Myers Squibb, Daiichi Sankyo, Sanofi Aventis, Novo Nordisk, Terumo. Konstantinos Koskinas has declared to have potential conflicts of interest to report: honoraria from MSD, Daiichi Sankyo, Sanofi. Steffen Petersen has declared to have potential conflicts of interest to report: consultancy for Circle Cardiovascular Imaging Inc. Calgary, Alberta, Canada. Emma Svennberg has declared to have potential conflicts of interest to report: Abbott, Astra Zeneca, Bayer, Bristol-Myers, Squibb-Pfizer, Johnson & Johnson.

In the quiet corridors of a seaside care home, on an ordinary weekday afternoon, a 92-year-old man sat confused in his wheelchair, gripping a butter knife he'd been using to eat his lunch. Within minutes, two police officers would arrive at his door after being alerted that it was vital for them to attend the scene quickly, as someone's life had been threatened…*** LISTENER CAUTION IS ADVISED *** This episode was researched and written by Eileen Macfarlane.Edited by Joel Porter at Dot Dot Dot Productions.Script editing, additional writing, illustrations and production direction by Rosanna FittonNarration, additional audio editing and mixing, and script editing by Benjamin Fitton.To get early ad-free access, including Season 1, sign up for They Walk Among PLUS, available from Patreon or Apple Podcasts.More information and episode references can be found on our website https://theywalkamonguspodcast.comMUSIC: Falling Skies by Louis Lion Darker Days by Alternate Endings Pursuit Of Wonder by Caleb Etheridge Road To Nowhere by Caleb Etheridge To What End by Caleb Etheridge Rampant by CJ0 Bane by Cody Martin Far From Home by Cody Martin Final Moments by Cody Martin Outer Rim by Cody Martin Rising Sun by Colossus Distant Water by Chelsea McGough Siege by Hill Creeper by Hill The Plot Thickens by Joshua Spacht Ancient Ground by Moments The Way Back by Moments Onward by Chelsea McGough SOCIAL MEDIA: https://linktr.ee/TheyWalkAmongUsSupport this show http://supporter.acast.com/theywalkamongus. Hosted on Acast. See acast.com/privacy for more information.

Ab 60 Jahren in die Muckibude? Häufiger ein Frühstücksei im Alter? Zurückhaltung bei der Blutdruckregulation? Persönlich wie auch fachlich besprechen Markus M. Lerch und Cornel Sieber die Besonderheiten bei Prävention und Therapien im Alter. Und was es eigentlich bedeutet, gebrechlich – also frail – zu sein.

Commentary by Dr. Xin Zhou.

Commentary by Dr. Mert Kaskal.

Blastober barrels forth with 2001's creepy psychological horror FRAILTY! FRAILTYDIRECTED BY: Bill PaxtonRELEASED: April 12, 2002STARRING: Bill Paxton, Matthew McConaughey, Powers Boothe, Luke Askew, Jeremy Sumpter BUDGET: $11mBOX OFFICE: $17,4mESTIMATED LOSS: $2mNEXT EPISODE: We wrap up Blastober with the third and final feature from a Master of Horror. SHOW NOTESAuto shop angelhttps://imgur.com/a/6Q7J43sScenes of Meat, TXhttps://imgur.com/a/g1kxxFn0:00 Intro 3:45 Show & tell8:30 This week's movie

Jade Greenfield • Psalm 77:1–77:20 • Steadfast

Jade Greenfield • Psalm 77:1–77:20

Welcome to The B-Side! Here we talk about movie stars! Not the movies that made them famous or kept them famous, but the ones that they made in between. Today we talk about a performer that we lost far too soon: Bill Paxton. Our B-Sides today include Brain Dead, Indian Summer, Traveller, and Frailty. Our guest is Billy Ray Brewton, and we cover a lot of ground. We dive into Paxton's Roger Corman origins (Crazy Mama getting reamed out by legend Stella Adler in New York, his ultimate move to Los Angeles, James Cameron, etc.), his love of movie-making and being on set, his tragic death, and much, much more. We mention his first directing gig (“Fish Heads” by Barnes & Barnes on SNL), his last directed feature (The Greatest Game Ever Played), and his recent podcast appearances before his death. There is also this charming late night appearance.

Targeting the biology of aging offers a path to stronger resilience and longer health. John C. Newman, M.D., Ph.D., explains that aging arises from measurable cellular processes, often called hallmarks of aging, including changes involving mitochondria, stem cells, cellular senescence, inflammation, and protein quality control. Newman describes how basic science in model organisms reveals mechanisms that can be manipulated to extend healthy lifespan and guide therapies. Emerging approaches aim either to strengthen stress responses that make cells more resilient or to address downstream consequences. Many clinical studies across the country now test interventions that target aging, supported by national efforts to standardize methods and expand training. Newman also investigates ketone bodies as energy sources that influence inflammation, muscle preservation, and other processes relevant to frailty and recovery. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40961]

Targeting the biology of aging offers a path to stronger resilience and longer health. John C. Newman, M.D., Ph.D., explains that aging arises from measurable cellular processes, often called hallmarks of aging, including changes involving mitochondria, stem cells, cellular senescence, inflammation, and protein quality control. Newman describes how basic science in model organisms reveals mechanisms that can be manipulated to extend healthy lifespan and guide therapies. Emerging approaches aim either to strengthen stress responses that make cells more resilient or to address downstream consequences. Many clinical studies across the country now test interventions that target aging, supported by national efforts to standardize methods and expand training. Newman also investigates ketone bodies as energy sources that influence inflammation, muscle preservation, and other processes relevant to frailty and recovery. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40961]

Targeting the biology of aging offers a path to stronger resilience and longer health. John C. Newman, M.D., Ph.D., explains that aging arises from measurable cellular processes, often called hallmarks of aging, including changes involving mitochondria, stem cells, cellular senescence, inflammation, and protein quality control. Newman describes how basic science in model organisms reveals mechanisms that can be manipulated to extend healthy lifespan and guide therapies. Emerging approaches aim either to strengthen stress responses that make cells more resilient or to address downstream consequences. Many clinical studies across the country now test interventions that target aging, supported by national efforts to standardize methods and expand training. Newman also investigates ketone bodies as energy sources that influence inflammation, muscle preservation, and other processes relevant to frailty and recovery. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40961]

Targeting the biology of aging offers a path to stronger resilience and longer health. John C. Newman, M.D., Ph.D., explains that aging arises from measurable cellular processes, often called hallmarks of aging, including changes involving mitochondria, stem cells, cellular senescence, inflammation, and protein quality control. Newman describes how basic science in model organisms reveals mechanisms that can be manipulated to extend healthy lifespan and guide therapies. Emerging approaches aim either to strengthen stress responses that make cells more resilient or to address downstream consequences. Many clinical studies across the country now test interventions that target aging, supported by national efforts to standardize methods and expand training. Newman also investigates ketone bodies as energy sources that influence inflammation, muscle preservation, and other processes relevant to frailty and recovery. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40961]

Targeting the biology of aging offers a path to stronger resilience and longer health. John C. Newman, M.D., Ph.D., explains that aging arises from measurable cellular processes, often called hallmarks of aging, including changes involving mitochondria, stem cells, cellular senescence, inflammation, and protein quality control. Newman describes how basic science in model organisms reveals mechanisms that can be manipulated to extend healthy lifespan and guide therapies. Emerging approaches aim either to strengthen stress responses that make cells more resilient or to address downstream consequences. Many clinical studies across the country now test interventions that target aging, supported by national efforts to standardize methods and expand training. Newman also investigates ketone bodies as energy sources that influence inflammation, muscle preservation, and other processes relevant to frailty and recovery. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40961]

BUFFALO, NY — October 14, 2025 — A new #research paper was #published in Volume 17, Issue 9 of Aging-US on August 30, 2025, titled, “Glycocalyx-targeted therapy prevents age-related muscle loss and declines in maximal exercise capacity.” In this study, led by Daniel R. Machin from the University of New Mexico School of Medicine and the University of Utah, researchers found that protecting a fragile layer lining blood vessels, known as the glycocalyx, can prevent muscle deterioration and help maintain physical performance during aging. They also discovered that a supplement containing high-molecular-weight hyaluronan (HMW-HA), a key component of the glycocalyx, enabled older mice to preserve muscle mass and exercise capacity. These findings suggest that targeting the glycocalyx may offer a new approach to reduce frailty and support mobility in older adults. As this layer degrades with age, it contributes to cardiovascular and muscular decline by impairing blood flow and vascular health. The study examined how preserving the glycocalyx using a therapy called Endocalyx™ affects physical function in aging mice. Researchers first studied genetically modified mice lacking Has2, the enzyme responsible for producing HMW-HA. These mice had a thinner glycocalyx, reduced exercise performance, and lower mitochondrial function in their muscles, even though muscle size remained normal. This indicated that glycocalyx damage alone can directly impair physical performance. The team then gave older mice a diet containing Endocalyx™ for 10 weeks. Compared to untreated controls, these mice maintained muscle mass and performed better on treadmill tests. Notably, the treated mice did not show the typical age-related decline in muscle strength and endurance. While the supplement did not fully restore youthful performance, it significantly slowed physical deterioration, suggesting a protective benefit. In contrast, untreated older mice lost both body mass and muscle volume during the same period. “Taken together, these findings provide direct evidence of a role for HMW-HA in the modulation of exercise capacity.” This research builds on prior evidence that the glycocalyx is essential for healthy blood vessel function. Since muscle health depends on proper blood flow and oxygen delivery, restoring the glycocalyx may help maintain strength and mobility with age. While more research is needed to confirm these results in humans, the findings point to a potential therapeutic approach to promote healthier aging. DOI - https://doi.org/10.18632/aging.206313 Corresponding author - Daniel R. Machin — dmachin@salud.unm.edu Abstract video - https://www.youtube.com/watch?v=S7HjCeXT8fU Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206313 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, glycocalyx, hyaluronan To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

I. Pastoral Humility. II. Pastoral Integrity. III. Pastoral Proximity.

Think strength training is just about building muscle? Think again. Your workouts activate myokines that positively influence nearly every organ in your body. In this episode, Amy Hudson and Dr. James Fisher break down the world of myokines--the powerful messengers released during exercise that can fight disease, sharpen your brain, and even slow aging. Expect to learn how strength training floods your body with health-boosting signals, why myokines are called “magic,” and ways strength protects both your lifespan and healthspan. Tune in to discover why muscle is the most underrated organ in your body—and how to tap into its hidden power. Dr. Fisher starts by describing why we need to think of muscle differently: It's not just tissue that moves your body, it's a chemical messenger system that sends positive signals all over the body.  Amy and Dr. Fisher cover why exercise is medicine. Each contraction releases myokines that calm inflammation, boost immunity, and even protect against cancer and neurological decline.  For decades, scientists knew muscles released “something,” but the name myokines wasn't coined until 2003. Now we know muscles are the largest endocrine organ in our bodies. Dr. Fisher explains the endocrine connection: Your muscles talk to organs the way your thyroid or pancreas does, constantly sending and receiving instructions.  According to Amy, you don't need six months of training before myokines start working. Just one resistance session floods your body with signals that improve energy, mood, and metabolism. How to fight belly fat naturally. According to Dr. Fisher, a myokine called interleukin-15 literally shrinks fat cells, making them store less. At the same time, it activates immune cells that protect you against tumors and infections. Amy compares myokines to magic. Science shows that training creates chemical changes that feel almost supernatural. The “magic” is your body healing itself from the inside out. Learn how exercise boosts your brain: Myokines like BDNF (Brain-Derived Neurotrophic Factor) act like fertilizer for your brain cells. They help you think sharper, learn faster, and protect against cognitive decline. Dr. Fisher explains why muscle growth isn't accidental. There's a molecule called myostatin that tries to limit your muscle growth. Resistance training shuts it down—so your muscles can grow instead of being held back. Amy explains the anti-aging effects of strength training.  Dr. Fisher highlights the consequences of aging without strength: Frailty, injuries, and dependence. Building strength is the single best insurance policy against that future. According to Amy, life is not about how long you live—it's about how long you can thrive. Myokines help you extend the years you can stay active, engaged, and vibrant. Amy and Dr. Fisher discuss how every squat, push, or pull unlocks healing compounds you can't get from a pill.  Amy's parting thoughts: Your body is wired to reward strength, that's why each workout delivers an immediate chemical payoff that makes you feel good.     Mentioned in This Episode: The Exercise Coach - Get 2 Free Sessions! Submit your questions at StrengthChangesEverything.com     This podcast and blog are provided to you for entertainment and informational purposes only. By accessing either, you agree that neither constitute medical advice nor should they be substituted for professional medical advice or care. Use of this podcast or blog to treat any medical condition is strictly prohibited. Consult your physician for any medical condition you may be having. In no event will any podcast or blog hosts, guests, or contributors, Exercise Coach USA, LLC, Gymbot LLC, any subsidiaries or affiliates of same, or any of their respective directors, officers, employees, or agents, be responsible for any injury, loss, or damage to you or others due to any podcast or blog content.

  WITH AN AXE!!!

BUFFALO, NY — October 3, 2025 — A new #research perspective was #published in Volume 17, Issue 9 of Aging-US on August 26, 2025, titled “Analysis of the current state of frailty indexes and their implementation for aging intervention studies.” In this work, led by first author Oliver G. Frost from Loughborough University alongside corresponding authors Abdelhadi Rebbaa and Amit Sharma, from the Lifespan Research Institute, the authors explore growing concerns about the lack of standardization in how frailty is measured in rodent aging studies, which may limit the development of effective interventions targeting age-related decline. Frailty, a key indicator of deteriorating health in older adults, is increasingly assessed in preclinical models using frailty indexes (FIs). These indexes quantify health deficits, such as reduced mobility, cognitive decline, or physical weakness. However, this perspective highlights that FI methodologies vary significantly across studies, from the selection of parameters to the cut-off thresholds used, resulting in inconsistent outcomes that affects reproducibility and translational value. The authors reviewed 18 rodent studies and found substantial variation in how frailty is defined and measured. Some FIs rely on clinical observations, such as appearance or beahaviour, while others focus on physical performance metrics like grip strength or locomotion. In several cases, applying different FIs to the same group of animals produced contradictory results, underscoring the importance of harmonized protocols. To illustrate these issues, the researchers applied an 8-item FI to mice of different ages and found that even young mice were sometimes scored as frail, depending on the scoring method and reference values. This finding emphasizes the need for consistent baselines and controlled environments, especially when comparing across studies. The authors recommend using each animal as its own baseline in longitudinal studies, a strategy that enhances reliability without adding significant cost. “Sex as a biological variable in FIs is an important consideration, as there is a known difference between male and female frailty onset and progression.” The authors also discuss emerging automated tools, such as video-based open-field testing, which can reduce observer bias and improve reproducibility. In the future, broader health indicators, such as cognition, circadian rhythms, social behavior, and body composition, may further enhance frailty assessments. Overall, this work underscores the urgent need for standardized, transparent, and reproducible methods for evaluating frailty in preclinical aging studies. Improved consistency in frailty scoring will better inform the development of healthspan-extending therapies and enhance the translational relevance of animal models. DOI - https://doi.org/10.18632/aging.206307 Corresponding authors - Abdelhadi Rebbaa - rebbaa@gmail.com, and Amit Sharma - amit.sharma@sens.org Abstract video - https://www.youtube.com/watch?v=eha3XA9LyWA Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206307 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, frailty, rodents, frailty index, phenotype To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

"Gain muscle mass and you will live longer.” ~ Dr. Jeff Gross. Dr Gross opens this episode with a simple truth backed by decades of clinical insight. Strategic exercise adds muscle, builds bone density, and prevents frailty. No marathon workouts required. In this conversation we unpack his weekly routine... short intervals, and one set to failure strength work. And then we explore how natural killer cell exosomes may support immune surveillance against cancer and zombie cells while protecting healthy tissue.

Join host Alex Crespo, MD as he chats with author Michael Weaver, MD about the Journal of Orthopaedic Trauma article on the Frailty Index as a possible stratification tool in the CMS hip fracture bundle. To access the abstract, click here. For additional educational resources visit OTA.org

This week we watched the 2001 psychological horror film Frailty. Directed by Bill Paxton, in his directorial debut, the plot focuses on the strange relationship between two young brothers and their father who believes that he has been commanded by God to destroy demons disguised as people. The film stars Paxton, Matthew McConaughey and Powers Boothe. Come join us!!! Website : https://tortelliniatnoon.com/ Instagram: https://www.instagram.com/tortelliniatnoonpodcast/ Facebook: https://www.facebook.com/TortelliniAtNoon Twitter: https://twitter.com/PastaMoviePod

Commentary by Dr. Jian'an Wang.

Just read the latest from NEJM? The PIpELINe Trial

Send us a textThe better than Van Helsing boys have spent their lives under the strict rule of their producer. Unaware of his dark past, they struggle to understand his increasingly erratic behavior. But when they begin to uncover the violent truths behind his mixing board, their world unravels, forcing them to confront having to produce the show without him. On Episode 683 of Trick or Treat Radio we discuss the film Abraham's Boys: A Dracula Story based on the short story from Joe Hill and directed by Natasha Kermani! We also talk about the upcoming Deathstalker film, isolationism and gaslighting from those you trust, and plenty of Dracula lore. So grab your monster hunting handbook, subvert any and all expectations, and strap on for the world's most dangerous podcast!Stuff we talk about: Steven Kostanski, The Void, Psycho Goreman, Frankie Freako, Deathstalker, Astron-6, practical FX, violence, sword and sorcery films, Jerry “The King” Lawler, f*ck WWE, The Incubus, Needful Things, the 13th Warrior, Eaters of the Dead, House of 1000 Corpses, Hunt for the Blood Orchid, Suspect Zero, Lets Scare Jessica to Death, The Last Exorcism, The Candyman, Watchmen, this day in horror history, Alexa Vega, bloody birthdays, The Tomorrow People, Machete Kills, Mothers Day, Psycho III, Zodiac, John Kassir, Rock and Shock, The Three Stooges, Benny and Joon, Will and Grace, Caveman, Todd Browning's Freaks, Rocket Ship XM, Invaders from Mars, Slash, Tim Seeley, Red Sonja, Rose McGowan, Deathwatch, The Dreadites, boomsword, Lucio Fulci, Conquest, covering the lens in vaseline, Sabrina Siana, Planet of the Gapes, Joe Hill, Abraham's Boys, Natasha Kermani, Titus Welliver, Jocelin Donahue, Frailty, Bill Paxton, PCU, Dogtooth, Yorgos Lanthimos, “the severed heads looked really good”, no style nor substance, Vanhelsing, movie of the week, “It's Better than Vanhelsing”, Batman, Monster: The Ed Gein Story, Wisconsin represents, Menendez Brothers, Brute 1976, Joe Knetter, Marcel Walz, Frute Brute, Countess Caramella, Brute 1976, Brut By Faberge, Mammoth, Robert Rodriguez, Greg Nicotero, Michael Jackson, Wolfgang Van Halen, Peter's Polar Bear Paradox, The Serial Killer Lookbook, Conquest and Divide, and The Ballad of Oswalt Patton.Support us on Patreon: https://www.patreon.com/trickortreatradioJoin our Discord Community: discord.trickortreatradio.comSend Email/Voicemail: mailto:podcast@trickortreatradio.comVisit our website: http://trickortreatradio.comStart your own podcast: https://www.buzzsprout.com/?referrer_id=386Use our Amazon link: http://amzn.to/2CTdZzKFB Group: http://www.facebook.com/groups/trickortreatradioTwitter: http://twitter.com/TrickTreatRadioFacebook: http://facebook.com/TrickOrTreatRadioYouTube: http://youtube.com/TrickOrTreatRadioInstagram: http://instagram.com/TrickorTreatRadioSupport the show

Feel like your midlife body has betrayed you? Stiffer joints, mysterious aches, less energy—these aren't just inconveniences, they're warning signals about your future independence. Dr. Vonda Wright, orthopedic surgeon, and author of "Unbreakable," returns to the show with a science-backed blueprint to prevent the broken hips, osteoporosis, and frailty plaguing too many women. As the country's leading voice on menopause's musculoskeletal impacts, she reveals why 70% of women experience debilitating joint pain and muscle loss. Plus, what are the six "time bombs" of aging you can control? How does your "unbreakable score" predict independence at 90? Why is muscle your literal longevity factory? Get the tools to stay strong, mobile, and unbreakable for decades ahead, beauties! FOLLOW A CERTAIN AGE: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠LinkedIn⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ GET INBOX INSPO: Sign up for our newsletter ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠AGE BOLDLY⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ We share new episodes, giveaways, links we love, and midlife resources Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Hoffman continues his conversation with Dr. Robert Silverman, author of "Immune Reboot: Maximizing Immunity, Restoring Gut Health, and Optimizing Vitality."

Dr. Robert Silverman, author of "Immune Reboot: Maximizing Immunity, Restoring Gut Health, and Optimizing Vitality," provides a comprehensive primer on the immune system. He explains how lifestyle factors—diet, sleep, exercise, and stress—impact immune resilience. He offers specific protocols for optimizing resistance to Covid, what to do if you come down with it, and how to treat Long Covid, as well as how to prepare for vaccines. 

In our update this month: For Wales:Preparing for the Senedd elections in 2026: https://www.rcslt.org/wales/#section-2 Work has begun on a Welsh language version of CAUK training, funded by the National Lottery. (See original CAUK training: https://communication-access.co.uk/) What's happened following the launch of the State of the Nation report (See here: https://www.rcslt.org/wales/#section-2 ) in January.Opportunities to get involved:Frailty task and finish group.Capturing evidence on the impact of Additional Learning Needs legislation for a Senedd committee inquiry.New survey for independent members.Around the UK:Behind the scenes on SEND reform and workforce matters.News about waiting list levels (people coming off) and graduate guarantee for nurses and midwives – AHP concern.Co-signed a letter to PM on oracy, Oracy 21.BSL plan for English education; Guernsey communication boardsBook your place at the RCSLT Conference 2025: https://www.rcslt.org/news/book-your-place-at-rcslt-conference-2025/  This interview was conducted by Victoria Harris, Head of Learning at The Royal College of Speech and produced and edited by freelance producer Jacques Strauss.Please be aware that the views expressed are those of the guests and not the RCSLT. Please do take a few moments to respond to our podcast survey: uk.surveymonkey.com/r/LG5HC3R     Please be aware that the views expressed are those of the guests and not the RCSLT.Please do take a few moments to respond to our podcast survey: uk.surveymonkey.com/r/LG5HC3R

On this episode of the Family Docs Podcast, we talk with Dr. Alex McDonald about vaccines – what family docs need to know now about vaccines, trends in vaccination rates, breaking and addressing vaccine myths, having vaccine conversations with patients, and how you can start getting involved in advocacy.  Guests: Alex McDonald MD, FAAFP, CAQSM is a former professional triathlete, Family and Sports Medicine physician and Associate Program Director  of the Kaiser Permanente Fontana Family Medicine Residency Program. Dr. McDonald is an AAFP and CAFP media spokesperson and social media ambassador with a passion for family physicians to raise their voice for their patients. Dr. McDonald regularly writes for the Physician's Weekly and contributes to the Physician's Weekly podcast. Dr. McDonald is a recipient of the 2025 AAFP Vaccine Science Fellowship and recently was awarded the California Immunization Coalition's 2025 Ronald P. Bangasser, Immunization Leadership Award. Resources: “Vaccine Misinformation, Pseudoscience, & the Frailty of Community Health” by Alex McDonald, MD, CAQSM, FAAFP - Dr. McDonald explores how vaccine misinformation and pseudoscience undermine public health and calls for a return to trust, truth, and evidence-based care. (https://www.physiciansweekly.com/post/vaccine-misinformation-pseudoscience-the-frailty-of-community-health) Family Medicine POP: Prism of Practice conference, September 5-7, 2025 (San Diego) - www.familydocs.org/pop CAFP's All Member Advocacy Meeting (AMAM), March 14-16, 2026 (Sacramento) - www.familydocs.org/amam  Information: The Family Docs Podcast is hosted by Rob Assibey, MD, FAAFP and Cynthia Chen-Joea, DO, FAAFP.  The Family Docs podcast is developed, produced, and recorded by the California Academy of Family Physicians. The views and opinions expressed in this program are those of the speakers and do not necessarily reflect the views or positions of any entities they represent or the California Academy of Family Physicians. More information at www.familydocs.org/podcast. Visit the California Academy of Family Physicians online at www.familydocs.org. Follow us on social media: Twitter - https://twitter.com/cafp_familydocs  Instagram - https://www.instagram.com/cafp_familydocs  Facebook - https://www.facebook.com/familydocs  LinkedIn - https://www.linkedin.com/company/california-academy-of-family-physicians 

On this episode, Aaron and Derek tackle 2001's psychological horror film "Frailty" directed by and starring Bill Paxton. They talk about Bill Paxton's creepy earnestness, how the writing cleverly handles multiple twists and reveals, and what makes this an effective horror movie without any jumpscares. They also get into McConaughey's proto-True Detective mannerisms, this flick's place between late 90s and aughts horror, and many other aspects of the movie. Aaron and Derek know that destroying demons is good. Support us on Patreon: https://www.patreon.com/WatchIfYouDare We are on PodBean, Apple Podcasts, Podchaser, Goodpods, Amazon Music, Spotify, iHeartRadio and CastBox. Please rate, review, subscribe, and share our show. Also, check out our Spotify Music playlist, links on our Twitter and Podbean page. Our socials are on Bluesky and Facebook and Twitter @WatchIfYouDare

On the podcast this week we focus our attention on vocal and instrumental trios – a subject we haven't featured before. We'll hear selections from The Carolina Chocolate Drops, Nightingale, The Jeremiahs, The Malvinas, The Wailin' Jennys and many more. Three scoops make a triple decker … this week on The Sing Out! Radio Magazine.Pete Seeger / “If I Had A Hammer”(excerpt) / Songs of Hope and Struggle / Smithsonian FolkwaysOld New England / “Scotty O'Neil-Jane's March-The Isle of Mull” / Old New England / Great MeadowCarolina Chocolate Drops / “Why Don't You Do Right” / Genuine Negro Jig / NonesuchMartin Simpson-Andy Cutting-Nancy Kerr / “The Sheffield Apprentice” / Big Bend Killing / Great Smoky Mountains AssociationNightingale / “Eric and the Angels-Jenny's Welcome to Charlie-Mariposa” / Trois / Self-producedSutton, Holt & Coleman / “Travelin' Man” / Ready for the Times / High Windy AudioThe Wailin' Jennys / “Wildflowers” / Fifteen / Red HouseBrace, Cooper & Jutz / “My Sally” / Profiles in Courage, Frailty & Discomfort / Red BeetOld New England / “The Kitchen-The Chicago Reel” / Old New England / Great MeadowThe Malvinas / “Somewhere off the Foot of the Mountains” / God Bless the Grass / Soona SongsGrisman-Hartford-Seeger / “When I'm Sixty-Four” / Retrograss / Acoustic DiscThe Jeremiahs / “Plough and Stars” / The Femme Fatale of Maine / Self-producedThe Loose Acoustic Trio / “Pinball Wizard” / Sorrow Be Gone / Big BookThe Skirtlifters / “Fire Bell Galop” / A Ragtime Episode / Self-producedKallet-Epstein-Ciccone / “Farthest Field” / Heartwalk / Self-producedPete Seeger / “If I Had A Hammer”(excerpt) / Songs of Hope and Struggle / Smithsonian Folkways

With one in two women expected to have an osteoporotic fracture in their lifetime, orthopaedic surgeon Dr Vonda Wright reveals the steps to take now to protect ourselves from this reality - and instead age with power.Liz and Vonda discuss how we can invest in both our physical and mental resilience to avoid osteoporosis, immobility, joint pain and bone fractures in later life, plus how motherhood, menopause, vaping and smoking impact our bones.Vonda shares the major exercise change to make to improve our strength, and the foods to prioritise to ensure you're getting enough calcium and protein (plus other essential nutrients you need) for your bones and muscles.This episode is currently only available to subscribers of The Liz Earle Wellbeing Show+. Subscribe via Apple for ad-free listening and 24 hour early access to each weekly episode.Links mentioned in the episode:Unbreakable: A Woman's Guide to Ageing with Power by Vonda WrightFollow Vonda Wright on InstagramOestrogen Matters by Avrum BlumingWhat is oestrogen and why it matters, with Professor Avrum BlumingThe midlife muscle crisis, with Dr Gabrielle LyonRoyal Osteoporosis SocietyA Better Second Half by Liz EarleHave a question for Liz? Send a WhatsApp message or voicenote to 07518 471846, or email us at podcast@lizearlewellbeing.com for the chance to be featured on the showPlease note, on some occasions, we earn revenue if you click the links and buy the products, but we never allow this to bias our coverage and always honestly review. For more information please read our Affiliate Policy. Hosted on Acast. See acast.com/privacy for more information.

It's no secret in 2025 that stronger muscles lead to longer life. If you're a woman in perimenopause, postmenopause or anything in between, this is no surprise to you. I think we are very aware of it, but let's unpack how weight lifting treats and prevents chronic diseases. Women, at any age, need stronger muscles for a longer life. Not just for aesthetics, but for functionality and independence.   My Guest: A longtime Vanity Fair contributing editor, Michael Joseph Gross has published investigative reporting, essays, and books about culture, technology, politics, religion, and business. He was raised in rural Illinois and lives in New York City.   Questions We Answer in This Episode: [00:04:31] How did this become a topic of interest to you personally?  [00:07:54] Let's connect strength training to prevention and treatment of illnesses often associated - even accepted - with aging? [00:20:17] Weight training has been shown to decrease anxiety and to have positive effects on risk of Alzheimer's or type 3 diabetes, can you explain for the listeners?  [00:26:31] How has the work of Dr. Maria Fiatarone Singh showed that weight training may reduce the risk of Alzheimer's? [00:33:13] Why is lifting heavy important? Do you worry that leading with “lift heavy” intimidates women? What did you uncover as evidence that it is never too late to start progressive strength training?   Why Strength Training? Strength training changes more than just your body—it's internal too. It's not about looking stronger—it's about being stronger. Adolescence and menopause are both times when women feel their bodies are changing without their consent. Strength training gives back a sense of control, capability, and power.   Stronger Muscles Longer Life At Any Age   Strong Youth: Peak bone mass forms in youth—strength training in adolescence builds lifelong health. A 10% increase in bone mass reduces future fracture risk by more than 50%.   Strong in Midlife: Dr. Maria Fiatarone Singh, geriatrician and professor in Sydney, Australia, found that even 90+ year-olds can gain muscle mass with high-intensity training. Weight training can treat and prevent nearly all chronic diseases.   Stronger Muscles Through Weight Lifting Treats and Prevents These Diseases: Type 2 Diabetes Heart Disease Osteoporosis Depression and Anxiety Insomnia Osteoarthritis Frailty Dementia & Alzheimer's Blood Pressure and Cholesterol Fall Risk   Periodization & Smart Strength Training: Periodization: Cycles of high effort, deloading, and rest. Women (especially Type A) tend to push too hard—leading to burnout or injury. Strength training should energize you, not exhaust you. Part of lifting heavy is lifting light. The goal: Live better, not just lift more.   Ancient Greek Lesson: The Right Time to Train Greek word kairos = the “opportune moment” for action. Good training is about doing the right thing at the right time. Don't blindly follow a plan. Train for your body today.   Connect with Michael: Michael's Website Twitter - DuttonBooks   Other Episodes You Might Like: Previous Episode - 5 Things I Would Do If I Were Tired All the Time  More Like This - What's Best Total Body or Split Routine in Menopause   Resources: Tune in to the upcoming Flipping 50 Masterclass. Don't know where to start? Book your Discovery Call with Debra.  

What if your greatest battles are within? Today's devotion invites you to uncover hidden weaknesses and guard your heart with wisdom and grace. Don't ignore the entanglements; face them with God's help.This was first aired on Radio HCI Today via the WeLove Radio App

The tension between faith and delusion builds to a thrilling climax in FRAILTY, the Bill Paxton-directed y2k crime drama with Christian themes. Matthew McConaughey, who we recently reviewed as a cast member of 1994's ANGELS IN THE OUTFIELD, stars as a man recounting his troubled childhood as the son of a religiously-motivated murderer (Bill Paxton) to a detective (Powers Boothe) who is trying to solve the case of the God's Hand killer. This killer, who McConaughey's character Fenton believes is his own brother Adam, targets seemingly random victims who are allegedly demons in human form. According to Fenton, his brother Adam is carrying out the legacy of their father, who experienced religious psychosis that led to a series of murders carried out with an axe the man believed to be a magical weapon provided by God. Young Fenton and Adam react to their father's passion for God and murder in different ways; Adam's naive admiration for his father foils Fenton's teenage skepticism. The two boys are possibly a metaphor for the human journey of faith and doubt, a reading supported by a surprising twist revealing the true nature of God's prophecy. FRAILTY does a great job of exploring Christian themes in an edgy way that condemns blind faith while still understanding the importance of faith itself. View our full episode list and subscribe to any of our public feeds: http://boysbiblestudy.com Unlock 2+ bonus episodes per month: http://patreon.com/boysbiblestudy Subscribe to our Twitch for livestreams: http://twitch.tv/boysbiblestudy Follow us on Instagram: http://instagram.com/boysbiblestudy Follow us on Twitter: http://twitter.com/boysbiblestudy

The profitable conveyor belt of osteoporosis—from bone density screening to powerful medications; Study reveals heart hazards of new bone-building drugs; Carbo-loading before endurance events—are we overdoing it? Barbie gets a CGM; Swallowable sensor in a pill reveals secrets of gut health; Dr. Jeffrey Bland introduces Himalayan Tartary Buckwheat as a hedge against age-related immune decline. 

Patricia Mae Santos is an assistant professor in the Department of Radiation Oncology at Emory University School of Medicine. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. P.M.G. Santos, R. Jagsi, and C.I.A. Oronce. Who Will Care for America? Immigration Policy and the Coming Health Workforce Crisis. N Engl J Med 2025;393:105-107.

AotKP is picking up the Bill...Paxton, that is! We're celebrating the cult icon with Frailty, Mortuary, and Aliens on this episode of Attack of the Killer Podcast! Listen & subscribe wherever you get your podcasts or go to http://www.aotkp.com Enter our contest: http://contest.aotkp.com/  Connect with the show: Become an Official Attacker: http://jointheattackers.com/ Visit our website: http://www.attackofthekillerpodcast.com/ Like us on https://www.facebook.com/attackofthekillerpodcast Follow us on https://twitter.com/AotKP Follow us on https://tiktok.com/@attackofthekiller  Follow us on https://www.instagram.com/attackofthekillerpodcast/ Follow us on https://www.threads.net/@attackofthekillerpodcast Subscribe on https://www.youtube.com/attackofthekillerpodcast Join us on https://www.aotkp.com/discord  Support the show at https://www.patreon.com/aotkp/posts Lastly, check out all the amazing shows at http://thepfpn.com

This month, on the WHOOP Podcast Longevity Series, WHOOP SVP of Research, Algorithms, and Data, Emily Capodilupo sits down with Dr. Linda Fried. Dr. Fried is a geriatrician, Dean of Columbia University's Mailman School of Public Health, and Founder of Experience Corps, a nationwide volunteer program for adults over the age of 50 to become literacy tutors in elementary schools. Emily and Dr. Fried discuss the effects of frailty, how to prevent it, and ways to take control of the aging process. Dr. Fried also discusses her path to public health, the lifestyle changes that promote longevity, and the powerful role of purpose and intergenerational connection in healthy aging.(00:30) Dr. Fried on Defining and Researching Frailty(05:44) Identifying Frailty & Frailty Prevention(07:57) Manifestations of Aging in 20 & 30 Year Olds(08:58) How Much of The Aging Process Is Within Our Control?(11:34) Dr. Fried's Journey to Public Health(13:58) Positive Lifestyle Impacts on Longevity(16:10) Experience Corps: Influence of Volunteer Work on The Aging Population(24:27) What Society Is Missing To Support Healthy Aging(25:44) Re-connecting Across Generations(34:02) The Starting Points for ChangeDr. Linda Fried:LinkedInExperience CorpsSupport the showFollow WHOOP: www.whoop.com Trial WHOOP for Free Instagram TikTok YouTube X Facebook LinkedIn Follow Will Ahmed: Instagram X LinkedIn Follow Kristen Holmes: Instagram LinkedIn Follow Emily Capodilupo: LinkedIn