Podcasts about European Heart Journal

ไลฟ์ #95: Apo B Containing Lipoproteins ประเภท ขนาด หรือจำนวนกันแน่ ที่ทำนายความเสี่ยงโรคหลอดเลือดหัวใจพี่ปุ๋มพบเห็นวิดีโอ โพสต์ ในโซเชียลมีเดียมากมาย ที่พูดว่าขนาดของ Apo B Containing Lipoproteins โดยเฉพาะ LDL particles ถ้ามีขนาดเล็ก หนาแน่น (small densed LDL) นั่นคือตัวร้าย แต่ถ้ามีลักษณะใหญ่ (Fluffy LDL) และ TG/HDL

❤️ Bonjour,Bienvenue dans ce nouvel épisode d'"En plein cœur", où l'on continue notre saga sur le cholestérol ! Aujourd'hui, je vous explique pourquoi ce n'est pas tant le cholestérol le problème, mais plutôt la manière dont il circule dans votre corps.

Boire du café pour vivre plus longtemps? C'est ce que suggère une étude scientifique menée par l'université américaine de Tulane et publié début janvier dans la revue European Heart Journal. On en parle avec Thierry Favrod-Coune, médecin et addictologue aux HUG. Avec le témoignage d'Anna Possi, la barista la plus âgée d'Italie! Journaliste: Juliane Roncoroni Réalisateur: Mathieu Ballmer >> Pour aller plus loin: - "Boire du café le matin serait bénéfique pour prévenir les maladies cardiovasculaires, selon une étude", RTSinfo, 13 février 2025 (en ligne) Nous écrire ou nous proposer des questions: +41 79 134 34 70 ou pointj@rts.ch

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-426 Overview: Drinking coffee offers potential health benefits—but does timing affect outcomes? This episode dives into new research on how morning vs. all-day coffee consumption impacts cardiovascular disease and all-cause mortality risk. Gain practical insights to optimize patient recommendations based on the latest evidence. Episode resource links: European Heart Journal (2025) 00, 1–11 https://doi.org/10.1093/eurheartj/ehae871 The Journal of Clinical Endocrinology & Metabolism, 2024, 00, 1–11 https://doi.org/10.1210/clinem/dgae552 Guest: Jillian Joseph, MPAS, PA-C   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-426 Overview: Drinking coffee offers potential health benefits—but does timing affect outcomes? This episode dives into new research on how morning vs. all-day coffee consumption impacts cardiovascular disease and all-cause mortality risk. Gain practical insights to optimize patient recommendations based on the latest evidence. Episode resource links: European Heart Journal (2025) 00, 1–11 https://doi.org/10.1093/eurheartj/ehae871 The Journal of Clinical Endocrinology & Metabolism, 2024, 00, 1–11 https://doi.org/10.1210/clinem/dgae552 Guest: Jillian Joseph, MPAS, PA-C   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-422 Overview: Conflicting data on alcohol's health effects leave clinicians uncertain about patient guidance. In this episode, we review the PREDIMED trial's findings on wine and cardiovascular outcomes, explore objective biomarkers for intake, and examine the National Academy of Sciences' recent report to clarify the risks and benefits of moderate consumption, giving you confidence in counseling patients. Episode resource links: Inés Domínguez-López, Rosa M Lamuela-Raventós, Cristina Razquin, et al. Urinary tartaric acid as a biomarker of wine consumption and cardiovascular risk: the PREDIMED trial, European Heart Journal, 2024;, ehae804, https://doi.org/10.1093/eurheartj/ehae804     National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. https://doi.org/10.17226/28582   Guest: Robert A. Baldor MD, FAAFP Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-422 Overview: Conflicting data on alcohol's health effects leave clinicians uncertain about patient guidance. In this episode, we review the PREDIMED trial's findings on wine and cardiovascular outcomes, explore objective biomarkers for intake, and examine the National Academy of Sciences' recent report to clarify the risks and benefits of moderate consumption, giving you confidence in counseling patients. Episode resource links: Inés Domínguez-López, Rosa M Lamuela-Raventós, Cristina Razquin, et al. Urinary tartaric acid as a biomarker of wine consumption and cardiovascular risk: the PREDIMED trial, European Heart Journal, 2024;, ehae804, https://doi.org/10.1093/eurheartj/ehae804   National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. https://doi.org/10.17226/28582   Guest: Robert A. Baldor MD, FAAFP Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

ไลฟ์ #90: หลักฐานทางคลินิคและพยาธิวิทยา ที่สนับสนุน “The zero-LDL Hypothesis”วันจันทร์ 24 ก.พ. 2568เวลา 20.00 น.✅ จากหลักฐาน A consensus statement from the European Atherosclerosis Society Consensus Panel“Low-density Lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic. Epidemiologic, and clinical studies.ตีพิมพ์ใน European Heart Journal 24 April, 2017 ซึ่งรวบรวมการติดตามคนไข้ไป 20 million person years พบความสัมพันธ์เชิงเส้นตรงระหว่างระดับ LDL-Cholesterol กับ ความเสี่ยงของโรคหลอดเลือดหัวใจ ยิ่งลดระดับ LDL-Cholesterol ได้ต่ำเท่าไหร่ ความเสี่ยงของโรคหลอดเลือดหัวใจก็ลดลงเท่านั้น✅ ถึงแม้ว่าจะมีหลักฐานทางคลินิกที่สนับสนุนผลลัพธ์ของการลดระดับ LDL-C ในการป้องกันการเกิดโรคหลอดเลือดหัวใจมากแค่ไหนก็ตาม มันก็ยังคงน่าสนใจเป็นอย่างยิ่งที่จะศึกษาว่า การลดระดับ LDL-C ให้ต่ำอย่างยิ่งยวด มีผลกระทบต่อภาวะธำรงดุลของไขมันในเลือด (Lipid Homeostasis) หรือไม่

Uno studio, pubblicato sull'European Heart Journal, condotto dagli scienziati del Cardiac Stress Laboratory presso il Brigham and Women's Hospital e della Harvard Medical School di Boston, ha evidenziato come il grasso nei muscoli può compromettere la salute del cuore. A Obiettivo Salute il commento del prof. Furio Colivicchi, Past Presidente Nazionale ANMCO e Direttore U.O.C Cardiologia Ospedale San Filippo Neri di Roma.

In this episode of Iron Radio, hosts Phil Stevens, Dr. Mike T. Nelson, Coach Jerrell, and Lonnie Lowry dive deep into various topics surrounding fitness and sports nutrition. They kick off with a discussion on a new study from the European Heart Journal about coffee drinking habits in the US and their impact on mortality rates. This leads to a broader conversation about nutrient timing, circadian rhythms, and the importance of regularity in diet and exercise. The hosts also reflect on the evolution of male physiques in movies over the past century, questioning why leading men looked significantly different in older films compared to today's standards. Tune in for a mix of scientific insights, personal anecdotes, and engaging banter on the ever-changing world of fitness and health.00:20 Meet the Hosts01:16 Latest Science on Coffee Consumption03:09 Impact of Coffee on Health11:18 Challenges in Scientific Research20:26 Dietary Intake and Metabolism27:58 Speculative Research and Regularity in Life29:18 Feast or Famine: The Evolution of Eating Habits30:43 Temporal Nutrition and Metabolic Flexibility32:45 The Impact of Glucose Monitoring36:36 Iron Radio Updates and New Platforms39:11 Changing Physiques: From Past to Present52:29 The Influence of Social Media on Fitness Perception Donate to the show via PayPal HERE.You can also join Dr Mike's Insider Newsletter for more info on how to add muscle, improve your performance and body comp - all without destroying your health, go to www.ironradiodrmike.com Thank you!Phil, Jerrell, Mike T, and Lonnie

SpaceTime Series 28 Episode 06Formation of Pluto-Charon Binary SystemA new study reveals that the formation of the Pluto-Charon dwarf planet binary system may mirror that of the Earth-Moon system. The research, published in Nature Geoscience, suggests that both systems feature a secondary body significantly large in comparison to the primary, unlike other moons in our solar system. The findings could explain Pluto's active geology and potential subsurface ocean, highlighting the significance of giant impacts in shaping planetary bodies.BepiColombo's Final Mercury FlybyThe BepiColombo spacecraft has completed its final close flyby of Mercury, passing just 295 kilometres above the planet's surface. This manoeuvre marks the last gravity assist required for the joint ESA and JAXA mission before it enters Mercury's orbit in late 2026. The mission aims to study Mercury's magnetic field, surface composition, and interaction with the solar wind, enhancing our understanding of planets close to their host stars.Astronomy Highlights for 20252025 promises exciting astronomical events, with the Sun's solar cycle nearing its peak. Highlights include a rare edge-on view of Saturn's rings, potential brightening of comet G3 Atlas, and two lunar eclipses. The year also features significant planetary alignments, meteor showers, and opportunities to observe the Southern Cross and the centre of the Milky Way. Dr. Nick Glom provides insights into these celestial events and more.00:00 This is space Time Series 28, Episode 6 for broadcast on 13 January 202500:27 A new study suggests the formation of the Pluto Charon dwarf planet binary system04:35 BepiColombo spacecraft makes its final flyby of Mercury09:27 This is space time. We take a look at the year ahead in astronomy10:47 Mid January will be a very interesting time to look at the night sky13:05 There are two big highlights in March with the eclipse of the moon and Saturn13:46 The other big event of course is the crossing of the rings of Saturn17:03 The Southern Cross is well positioned during the month of June18:38 Venus and Jupiter are the two brightest planets in the night sky19:16 Also in August, it's a great time to have a look at Sagittarius20:35 Total eclipse of the Moon occurs when Moon moves into Earth's shadow23:06 The Australasian Sky Guide has just released its 30th edition25:05 World Meteorological Organisation confirms that 2024 was the warmest year on record29:34 It's claimed that two allegedly Celtic heads could turn you into a werewolfwww.spacetimewithstuartgary.comwww.bitesz.com

En este episodio analizamos un estudio publicado en el European Heart Journal que investigó si el momento del día en que tomamos café influye en nuestra salud. El estudio incluyó datos de más de 40,000 adultos estadounidenses obtenidos a través de la Encuesta Nacional de Salud y Nutrición (NHANES), complementados con datos del Estudio de Validación del Estilo de Vida de Mujeres y Hombres. Los investigadores identificaron dos patrones principales de consumo:Patrón matutino: consumo de café limitado a las horas de la mañana (36% de los participantes).Patrón de todo el día: consumo de café repartido a lo largo de toda la jornada (14% de los participantes).Durante un seguimiento mediano de 9.8 años, se registraron:4,295 muertes por todas las causas.1,268 muertes por enfermedades cardiovasculares.934 muertes por cáncer.Los resultados mostraron que las personas con el patrón de consumo matutino tenían un menor riesgo de mortalidad por todas las causas (reducción del 16%) y un riesgo aún más bajo de mortalidad por enfermedades cardiovasculares (reducción del 31%) en comparación con quienes no consumían café. Además, se observó que una mayor ingesta de café estaba asociada con un menor riesgo de mortalidad solo en aquellos con el patrón matutino, no en quienes bebían café durante todo el día.Sin embargo, al tratarse de un estudio observacional, es importante señalar que estos resultados muestran asociaciones, no causalidades. Aunque se ajustaron factores como horas de sueño, consumo de café con cafeína y descafeinado, y otras variables, no se puede descartar que existan otros factores que influyan en los resultados.En conclusión, el estudio sugiere que tomar café por la mañana podría ser más beneficioso para la salud que hacerlo en otros momentos del día, pero se necesitan más investigaciones, especialmente ensayos controlados, para confirmar estos hallazgos.¿Deberíamos replantearnos nuestra rutina con el café?FUENTE: https://static.primary.prod.gcms.the-infra.com/static/site/eurheartj/document/ehae871.pdf?node=9616b797bc65f23e8519Conviértete en un seguidor de este podcast: https://www.spreaker.com/podcast/comiendo-con-maria-nutricion--2497272/support.

Il mattino, oltre ad avere l’oro in bocca, sarebbe anche il momento ideale per bere il caffè. A sottolinearlo uno studio americano pubblicato sull'European Heart Journal che dimostra come la tazzulella di caffè bevuta al mattino èamica della salute del cuore. A Obiettivo Salute il commento del prof. Claudio Borghi, direttore dell'unità operativa di medicina interna al Policlinico Sant'Orsola-Malpighi di Bologna.

 In this episode of Daily Value, we examine the latest research on wine consumption and its relationship to cardiovascular health. Leveraging urinary tartaric acid as an objective biomarker, a recent study (PMID: 39689849) published in the European Heart Journal provides interesting evidence of a J-shaped association between wine intake and cardiovascular outcomes.Discussion Points:Biomarkers and Bias: The role of urinary tartaric acid in providing a reliable objective measure of wine consumption, avoiding the recall and social desirability biases inherent in self-reported dietary studies.Mechanisms of Action: The potential cardioprotective effects light to moderate wine intake (are they real?)Dose-Dependent Effects: Insights into the J-shaped curve, revealing cardiovascular benefits with light-to-moderate consumption and increased risk with heavier intake.https://pubmed.ncbi.nlm.nih.gov/39689849/ Support the show

We know the literature on mechanical CPR devices on mortality in out of hospital cardiac arrest (we DO know this literature, right?), but what about in-hospital arrest? Dr. Jarvis reviews a recent paper that uses the AHA Get With The Guidelines - Resuscitation registry to assess the association between MCDs and mortality. Citations1. Crowley C, Salciccioli J, Wang W, Tamura T, Kim EY, Moskowitz A: The association between mechanical CPR and outcomes from in-hospital cardiac arrest: An observational cohort study. Resuscitation. 2024;May 1;198.2. Rubertsson S, Lindgren E, Smekal D, Östlund O, Silfverstolpe J, Lichtveld RA, Boomars R, Ahlstedt B, Skoog G, Kastberg R, et al.: Mechanical Chest Compressions and Simultaneous Defibrillation vs Conventional Cardiopulmonary Resuscitation in Out-of-Hospital Cardiac Arrest: The LINC Randomized Trial. JAMA. 2014;January 1;311(1):53–613. Hardig BM, Lindgren E, Östlund O, Herlitz J, Karlsten R, Rubertsson S: Outcome among VF/VT patients in the LINC (LUCAS IN cardiac arrest) trial—A randomised, controlled trial. Resuscitation. 2017;June;115:155–62.4.  Perkins GD, Lall R, Quinn T, Deakin CD, Cooke MW, Horton J, Lamb SE, Slowther A-M, Woollard M, Carson A, et al.: Mechanical versus manual chest compression for out-of-hospital cardiac arrest (PARAMEDIC): a pragmatic, cluster randomised controlled trial. The Lancet. 2015;385(9972):947–55.5.  Wik L, Olsen J-A, Persse D, Sterz F, Lozano M, Brouwer MA, Westfall M, Souders CM, Malzer R, Van Grunsven PM, et al.: Manual vs. integrated automatic load-distributing band CPR with equal survival after out of hospital cardiac arrest. The randomized CIRC trial. Resuscitation. 2014;June;85(6):741–8.6. Bonnes JL, Brouwer MA, Navarese EP, Verhaert DVM, Verheugt FWA, Smeets JLRM, Boer M-J de: Manual Cardiopulmonary Resuscitation Versus CPR Including a Mechanical Chest Compression Device in Out-of-Hospital Cardiac Arrest: A Comprehensive Meta-analysis From Randomized and Observational Studies. Ann Emerg Med Annals of emergency medicine. 2016;67(3):349-360.e3.7. Gonzales L, Oyler BK, Hayes JL, Escott ME, Cabanas JG, Hinchey PR, Brown LH: Out-of-hospital cardiac arrest outcomes with “pit crew” resuscitation and scripted initiation of mechanical CPR. The American Journal of Emergency Medicine. 2019;May;37(5):913–20.8. Koster RW, Beenen LF, Van Der Boom EB, Spijkerboer AM, Tepaske R, Van Der Wal AC, Beesems SG, Tijssen JG: Safety of mechanical chest compression devices AutoPulse and LUCAS in cardiac arrest: a randomized clinical trial for non-inferiority. European Heart Journal. 2017;October 21;38(40):3006–13.9. Primi R, Bendotti S, Currao A, Sechi GM, Marconi G, Pamploni G, Panni G, Sgotti D, Zorzi E, Cazzaniga M, et al.: Use of Mechanical Chest Compression for Resuscitation in Out-Of-Hospital Cardiac Arrest—Device Matters: A Propensity-Score-Based Match Analysis. JCM. 2023;June 30;12(13):4429.10. Youngquist ST, Ockerse P, Hartsell S, Stratford C, Taillac P: Mechanical chest compression devices are associated with poor neurological survival in a statewide registry: A propensity score analysis. Resuscitation. 2016;September;106:102–7.11.  S, Sulzgruber P, Datler P, Keferböck M, Poppe M, Lobmeyr E, Van Tulder R, Zajicek A, Buchinger A, Polz K, et al.: Mechanical chest compression does not seem to improve outcome after out-of hospital cardiac arrest. A single center observational trial. Resuscitation. 2015;November;96:220–5. 12. Morgan S, Gray JJ, Sams W, Uhl K, Gundrum M, McMullan J: LUCAS Device Use Associated with Prolonged Pauses during Application and Long Chest Compression Intervals. Prehospital Emergency Care. doi: 10.1080/10903127.2023.2183294 (Epub ahead of print).13.  Levy M, Yost D, Walker RG, Scheunemann E, Mendive SR: A quality improvement initiative to optimize use of a mechanical chest compression device within a high-performance CPR approach to out-of-hospital cardiac arrest resuscitation. Resuscitation. 2015;July;92:32–7.14.  Li H, Wang D, Yu Y, Zhao X, Jing X: Mechanical versus manual chest compressions for cardiac arrest: a systematic review and meta-analysis. Scand J Trauma Resusc Emerg Med. 2016;December;24(1):10.15.  Sheraton M, Columbus J, Surani S, Chopra R, Kashyap R: Effectiveness of Mechanical Chest Compression Devices over Manual Cardiopulmonary Resuscitation: A Systematic Review with Meta-analysis and Trial Sequential Analysis. WestJEM. 2021;July 19;22(4):810–9.16.  Wang PL, Brooks SC: Mechanical versus manual chest compressions for cardiac arrest. Cochrane Database Syst Rev The Cochrane database of systematic reviews. 2018;20;8:CD007260.17.  Zhu N, Chen Q, Jiang Z, Liao F, Kou B, Tang H, Zhou M: A meta-analysis of the resuscitative effects of mechanical and manual chest compression in out-of-hospital cardiac arrest patients. Crit Care. 2019;December;23(1):100.

Our initial review of the PLATO trial, published in April 2024, was based on the data available to us at that time. We have since became aware of new information that reduces our confidence in the PLATO results. This new information has major implications for clinical practice. Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber.Despite representing only 6.9% of the total P2Y12 inhibitor prescriptions among Medicare beneficiaries in 2020, Ticagrelor accounted for nearly two-thirds of total Medicare spending on these drugs in the same year. We summarize important points below but you can refer to this investigation at BMJ for more details.1. Unexplained Regional Variation: In our original review, we highlighted the treatment effect interaction based on region of enrollment, where ticagrelor was less effective compared to clopidogrel for patients enrolled in North America. It appeared to be a strong signal and was associated with a p-value for the interaction of 0.05. However, we were cautious in our interpretation since overall, patients enrolled in North America represented a relatively small fraction of total patients and we could not think of a reasonable explanation.Information in the BMJ investigation now sheds new light on these findings. In our review, we only presented data contained in the supplement accompanying the PLATO trial manuscript, which categorized patients based on region of enrollment but did not provide country specific information. The BMJ report notes that in a separate subgroup analysis, based on country of randomization, the primary outcome was numerically higher with ticagrelor in the United States (12.6% vs 10.1%, HR: 1.27, 95% CI: 0.92 – 1.75). This subgroup represented 7.6% of the total trial participants. Overall, 9.7% of trial participants were enrolled from North America. This means the US data drove the findings from the North American subgroup.The explanation provided by AstraZeneca (the manufacturer of ticagrelor) to explain the observed treatment effect heterogeneity was that aspirin dosing in the United States was higher than in other countries. It even led the FDA to issue a black box warning to avoid an aspirin maintenance dose of >100 mg in patients taking ticagrelor. An extensive statistical analysis of the regional variation in PLATO yielded four interesting points. First what was the prior likelihood of observing a ticagrelor vs clopidogrel HR of > 1.25 in the US, when the overall HR was actually equal to 0.84? That probability is ≤ 0.01. This alone suggests more than chance. Second point: a strong US/nonUS interaction was noted for each of the 3 components of the primary endpoint—CV death, MI, stroke. Third: they found a very strong interaction between treatment and median aspirin dose, and, importantly, the aspirin interaction effect was similar in US and nonUS settings. Fourth, an analysis of contract research organization (CRO) vs sponsor monitoring of the site accounted for 61% of the treatment-by- region interaction. The authors downplayed this finding because of the four countries monitored by a CRO (Israel, US, Georgia and Russia), the US made up the majority and thus is confounded by the aspirin interaction. Noteworthy was a lack of direct analysis of CRO vs sponsor test for interaction. One problem though: the BMJ investigation found that the lead author, Kevin Carroll was the head statistician at AstraZeneca and had worked at the company for 20 years. Carroll presented the PLATO results at the FDA advisory meeting. The paper lists Carroll as having no conflicts. Carroll told the BMJ that he had disposed of all conflicts of interest before submitting that analysis. But, in our opinion, the aspirin explanation does not pass muster because of biologic implausibility. See next section: How would a higher dose of aspirin reduce the efficacy of ticagrelor?The primary composite endpoint was vascular death, MI or stroke. If the higher aspirin dose impacted this, we would hypothesize that it caused more major bleeding in the ticagrelor group with some events resulting in vascular death, type 2 MI and hemorrhagic stroke, driving the treatment effect in favor of clopidogrel. But there is no evidence of this.The figure below is from the original subgroup plots provided in the PLATO supplement. The difference in the treatment effect for the primary endpoint for North American patients is striking but there is no difference for major bleeding.In our opinion and the opinion of others, the role of supervision of the centers could be important. Most centers were monitored by the sponsor. Four countries (Israel, US, Georgia and Russia) were monitored by a contract research organization. All four of these countries had numerically higher rates of the primary outcome in the ticagrelor group. This has major implications and we do not take them lightly. Essentially, it suggests malfeasance on the part of the sponsor. So is there anything else to support such a claim? Well, yes. 2. Concerns about event adjudication. Based on a report from Victor Serebruany, an adjunct faculty member at Johns Hopkins University, and the BMJ investigation, FDA records indicated that site reports documented 504 myocardial infarctions in patients who received ticagrelor compared to 548 in patients who received clopidogrel. However, after adjudication, the count increased only for the clopidogrel group, reaching 593. There was also some imbalance among groups in adjudicating death. These imbalances raise concerns about potential unblinding and result tampering. We read many of the authors' replies and we did not find a clear explanation of why all readjudicated extra MIs were in the clopidogrel group (45 clopidogrel; ticagrelor 0). 3. There were also concerns about the accuracy of death records as sites death records did not always match the FDA records.We cite from the BMJ: The BMJ's analysis also found omissions in PLATO's landmark publication. The paper, published in NEJM and reported as an intent-to-treat analysis, reports 905 total deaths from any cause among all randomized patients. An internal company report states, however, that 983 patients had died at this point. While 33 deaths occurred after the follow-up period, the NEJM tally still leaves out 45 deaths “discovered after withdrawal of consent.” The BMJ obtained some records for patients whose deaths were not reported in NEJM (see table 1) and asked the journal for a response.NEJM editor in chief Eric Rubin told The BMJ that “for older manuscripts, correction is not necessarily appropriate unless there would be an effect on clinical practice,” concluding that “it does not appear that correcting this 15-year-old article is going to have any impact.”It is noteworthy that the United States Department of Justice launched a formal investigation into the PLATO trial in 2013; however, the probe was closed in 2014. The BMJ column cited a spokesperson for the US attorney's office who said…”we determined that the allegations lacked sufficient merit such that it was not in the best interests of the US to intervene in the suit.” 4. Mortality reduction in PLATO defies explanation: Shortly after PLATO was published, Drs. Victor Serebruany and Dan Atar wrote an editorial in the European Heart Journal titled: The PLATO trial: do you believe in magic? They noted that the overall HR for all-cause death ticagrelor vs clopidogrel was 0.78 (95% CI: 0.69 - 0.89; p< 0.001). There were 107 more lives saved with ticagrelor vs clopidogrel. To explain the surprise of this massive effect size, they compared it to the COMMIT trial of clopidogrel vs placebo in patients with acute MI. In COMMIT, 119 lives were saved with clopidogrel (vs placebo), but COMMIT had three-fold more patients than PLATO—and the gain was vs placebo. They tempt the reader to ask: how could ticagrelor fare that well against a drug that crushed placebo? We note two other reasons to be concerned about the outsized mortality reduction in PLATO. One is plausibility. The all-cause mortality benefit exceeded the reduction in MI, CV death or stroke. Given the numerically higher rate of bleeding, how else does ticagrelor reduce death vs clopidogrel? The second reason is the lack of such a signal in Phase 2 studies, such as this one. 5. PLATO results are on outlier: Multiple observational studies have failed to replicate the benefits of ticagrelor observed in the PLATO trial. While observational studies are inherently limited by confounding factors and are inferior to randomized trials, their findings warrant a re-evaluation of ticagrelor's benefits. Furthermore, two randomized trials—one conducted predominantly in Japanese patients and another in South Korea—did not demonstrate the superiority of ticagrelor, instead showing higher bleeding rates and a numerical increase in ischemic events.Ticagrelor also significantly underperformed against another new antiplatelet drug, prasugrel. In the non-industry-funded ISAR-REACT 5 trial, which enrolled patients with acute coronary syndrome, the primary event of death, MI, or stroke was 36% higher in the ticagrelor arm (9.3% vs 6.9%, HR 1.36, 95% CI: 1.09 - 1.70). Major bleeding was also numerically higher in the ticagrelor arm. 6. PLATO authors have responded to these arguments.We provide links to four of the authors responses. * Thrombosis and Hemostasis https://www.wellesu.com/10.1160/TH11-03-0162* Stroke https://www.ahajournals.org/doi/10.1161/strokeaha.111.000514* Inter J of Cardiol https://doi.org/10.1016/j.ijcard.2014.06.029* Circulation https://doi.org/10.1161/CIRCULATIONAHA.111.047498Conclusion These are vitally important revelations regarding PLATO and ticagrelor. The FDA advisory committee recommended that FDA require a confirmatory trial. This was not done. As such, ticagrelor gained serious market share in the non-clopidogrel antiplatelet market for more than a decade. Yet no other compelling evidence for its benefit over clopidogrel has come to light. It clearly underperformed vs prasugrel. These old and new revelations have changed our positive view of ticagrelor. We no longer have confidence in this drug. We strongly agree with the recommendation for another properly controlled trial. We also believe this highlights the benefits of having either two regulatory trials or a single regulatory trial combined with a mandated post-approval trial. These revelations also emphasize the benefits of robust critical appraisal and skeptical but not cynical approaches to surprising evidence. Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber. Get full access to Cardiology Trial's Substack at cardiologytrials.substack.com/subscribe

We had a great NephJC get together. We recorded the whole event and packaged it into a podcast.Musical entertainmentTim Yau (@Maximal_Change)Too Sweet by HozierFairy Tale of New York by written Jem Finer and Shane MacGowan. Hear it performed by the Pogues.Interview of Tom MuellerTom Mueller author of How to Make a KillingJade Teakall@jmteakellGraham Abra@GrahamAbraInterview of Tom MuellerTom Mueller author of How to Make a KillingJade Teakall @jmteakellGraham Abra @GrahamAbraNephMadness logo revealNephJC KidneysNephJC blog postNephJC Manuscript of the Year: Flow accepted by Meg JardineManjula Kurella Tamura, winner of the 2015 NephMadness, oh and author of NEJM manuscripts and subject of a NYT article.NephJC Visual Abstract of the Year: Corina Teodusiu, creator of the Flozinator logoNephJC Social Justice Award: ISN petition to the WHO on Kidney HealthMost Engaged Scientist Award: Michelle RheaultRookie of the Year: Milagros FloresMVP: Christina PopaNephJC Founders Award: Joshua WaitzmanNathan Hellman Social Media Project of the Year: Edgar Lerma and the ASN Visual Abstract TeamMore Music with TimSaginaw, Michigan as performed by Johny CashBetty, written by Taylor SwiftThe Kidney ConnectionFreely Filtered Kidney Week DraftPrevious drafts2021 ASN Kidney Week Draft2022 ASN Kidney Week Draft2023 ASN Kidney Week DraftList of all the simultaneous publications from Kidney Week 2024Sophia: SMART Trial (Link goes to the new KidneyCompass podcast that interview lead author Hiddo HeerspinkJordy's editorial in the European Heart Journal. LinkJosh: APPLAUSE Alternative Complement Pathway Inhibition with Iptacopan in IgA Nephropathy in the NEJMAPPLAUSE results announcement at The World Congress of Neophrology in Buenos AriesIptapocan is a factor B inhibitionJordy: POISE-3 with simultaneous publication in KIMentions she wanted to pick KAT-AKI because she worked with Perry Wilson.Per Nayan, Amit Garg is the Beyonce of NephrologyAccord Trial (NEJM)Joel: HSK21541 for PruritusCorrection link to source (graph)Nayan: FINEARTS-HF with simultaneous publication in JACCBARACH-D: Low-dose spironolactone and cardiovascular outcomes in moderate stage chronic kidney disease: a randomized controlled trial (Nature Medicine)Swapnil comes out as a SpiroStanTOPCAT funny businessPATHWAY-2 Trial (NephJC coverage)Swap: K Bath and cardiac arrhythmia with simultaneous publication in Kidney InternationalCAST: A study that rocked the cardiology world and became the poster child for evidence-based medicine (Link)Tubular SecretionsSwap: Late breaking and high impact sessionsNayan: Intro to…Joel: Student poster on blood pressure techniqueJordy: The Penguin. A couple of mentee postersSophie: Tracks her sessions on paper.Josh: Quiz and Questionaire session with JC Velez, Bea Concepcione, Anna Burgner, Roger Rodby.

Nutritionist Leyla Muedin delves into the reconsideration of alcohol consumption during the holiday season. With increasing awareness of the effects of alcohol on sleep and overall health, Leyla discusses a study from the European Heart Journal that links excessive alcohol intake to heart arrhythmias, using data from the Munich Beer Related Electrocardiogram Workup Study (MunichBREW). The episode explores the broader cardiovascular impacts of alcohol, such as elevated heart rate, atrial fibrillation, and high blood pressure. By highlighting that alcohol is a mitochondrial poison and neurotoxin, the discussion extends to its role in causing weight gain, liver disease, certain cancers, and mood disorders. Leyla encourages listeners to reevaluate their drinking habits and consider alternatives like alcohol-free beverages to achieve better health outcomes during a season known for indulgence.

In today's episode of Cardiology Digest, we look at three recent research papers that can impact your clinical practice. They're from NEJM Evidence, the European Heart Journal, and The New England Journal of Medicine. STUDY #1: Today's journey begins with a study examining the interplay between influenza and myocardial infarctions. Could the flu shot be more than just a seasonal precaution?   de Boer, AR, Riezebos-Brilman, A, van Hout, D, et al. 2024. Influenza infection and acute myocardial infarction. NEJM Evid. 7:EVIDoa2300361. (https://doi.org/10.1056/EVIDoa2300361) STUDY #2: Next, we wade into a cath lab debate over fasting protocols. Join us to explore research that flips traditional pre-procedure fasting requirements on their head. Are we on the brink of a new era?  Ferreira, D, Hardy, J, Meere, W, et al. 2024. Fasting vs no fasting prior to catheterisation laboratory procedures: The SCOFF trial. Eur Heart J. Published online. (https://doi.org/10.1093/eurheartj/ehae573) STUDY #3: Finally, we dig into the complexities of anticoagulation in transcatheter aortic-valve replacement patients. This study sheds light on the choice between interrupting or continuing anticoagulation, and has implications for everyday practice. van Ginkel, DJ, Bor, WL, Aarts, HM, et al. 2024. Continuation versus interruption of oral anticoagulation during TAVI. N Engl J Med. Published online. (https://doi.org/10.1056/NEJMoa2407794) Tune in for a captivating discussion that promises to enrich your clinical acumen!  Learn more with Medmastery's courses: Coronary Angiography Essentials (3 CME) Coronary Angiography Essentials Workshop (1 CME) ICD Essentials (4 CME) ICD Essentials Workshop (1 CME) Pacemaker Essentials (5 CME) Pacemaker Essentials Workshop (1 CME) Percutaneous Coronary Intervention Essentials (6 CME) Percutaneous Coronary Intervention Essentials Workshop (6 CME) Get a Basic or Pro account, or, get a Trial account. Show notes: Visit us at  https://www.medmastery.com/podcasts/cardiology-podcast.

A tavola non si invecchia, ma non solo. Si può proteggere anche il cuore. Quali sono i suoi gusti? A Obiettivo Salute in tavola ci occupiamo della salute del cuore. Questa è la sua giornataCon il dottor Lorenzo Menicanti, Direttore Scientifico del Policlinico San Donato e Presidente Rete Cardiologica IRCCS parliamo dello studio CVRISK-IT, un progetto di prevenzione primaria delle malattie cardiovascolari, promosso dal Parlamento italiano e finanziato dal Ministero della Salute, a cui prenderanno parte 17 IRCCS della Rete Cardiologica, coordinati dall'IRCCS Policlinico San Donato, con estensione su tutto il territorio italianoIntervengono anche il prof. Antonio Moschetta, ordinario di Medicina interna dell'Ateneo di Bari e direttore dell Unità operativa complessa di medicina interna presso la Clinica Medica Frugoni del Policlinico di Bari, per parlare di sovrappeso e giro vita e il prof. Rocco Montone, cardiologo presso la Uoc Cardiologia Intensiva di Fondazione Policlinico Universitario Agostino Gemelli Irccs - Università Cattolica, che ha coordinato un’ampia review pubblicata su European Heart Journal che prende in esame i fattori non tradizionali di rischio cardio-vascolare del terzo millennio come l’inquinamentoIn chiusura Radio 24 e Touring Club Italiano sono ancora insieme per celebrare le meraviglie nascoste del nostro paese con l'appuntamento "Caccia ai tesori Arancioni 2024", l'iniziativa di Touring Club Italiano giunta alla sua quinta edizione che si svolgerà il 6 ottobre contemporaneamente in tutta Italia. Un viaggio alla scoperta delle piccole eccellenze del nostro Paese, attraverso percorsi unici che si snodano nei 100 borghi certificati con la Bandiera Arancione. Ospite Morena Concari, Consigliera comunale (con delega a Turismo e Cultura) e curatrice del libro “Prima che si perda il capo”, edito nel 2024 dalla Proloco di Monteverdi Marittimo (Pisa) con l’obiettivo di far conoscere la tradizione culinaria italiana e la storia del territorio della Maremma, portandola avanti per preservare una parte fondamentale della nostra cultura

In this special episode titled “Lipids – Beyond Statins and LDL Cholesterol”, our host, Dr. Neil Skolnik will discuss with two expert guests the details of treatment for LDL-Cholesterol, Triglycerides, and other lipid risk markers.  This special episode is supported by an independent educational grant from Amarin. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health James Underberg, M.D. , Clinical Assistant Professor of Medicine at NYU School of Medicine and the NYU Center for Prevention of Cardiovascular Disease, Director of the Bellevue Hospital Lipid Clinic, and Past President of the National Lipid Association. Layla A. Abushamat, M.D., MPH, Assistant Professor, Department of Medicine in the Division of Atherosclerosis and Vascular Medicine, Baylor College of Medicine,  Houston, Texas   Selected references referred to the in the Podcast: 1.     Icosapent Ethyl: REDUCE-IT - N Engl J Med 2019; 380:11-22 2.     Omega-3 Fatty Acids: STRENGTH trial - JAMA. 2020;324(22):2268-2280 3.     Lipoprotein(a) Blood Levels and Cardiovascular Risk Reduction With Icosapent Ethyl. JACC. 2024 Apr, 83 (16) 1529–1539 4.     Icosapent ethyl following acute coronary syndrome. European Heart Journal 2024; 45:1173–1176 5.     Cardiovascular Disease and Risk Management: ADA Standards of Care in Diabetes—2024. Diabetes Care 2024;47(supp 1): S179–S218

Trimethylamine-N-oxide (TMAO) is a harmful compound produced by gut bacteria. Elevated TMAO levels can significantly influence the development of heart disease, type 2 diabetes, chronic kidney disease, cancer, and fatty liver disease. Listen in this week as Dee explains which foods increase the production of TMAO in the gut, and how you can optimize the health of your gut.References:Li, X. S., Obeid, S., Klingenberg, R., Gencer, B., Mach, F., Räber, L., Windecker, S., Rodondi, N., Nanchen, D., Muller, O., Miranda, M. X., Matter, C. M., Wu, Y., Li, L., Wang, Z., Alamri, H. S., Gogonea, V., Chung, Y. M., Tang, W. H., Hazen, S. L., … Lüscher, T. F. (2017). Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors. European Heart Journal, 38(11), 814–824. https://doi.org/10.1093/eurheartj/ehw582Shan, Z., Sun, T., Huang, H., Chen, S., Chen, L., Luo, C., Yang, W., Yang, X., Yao, P., Cheng, J., Hu, F. B., & Liu, L. (2017). Association between microbiota-dependent metabolite trimethylamine-N-oxide and type 2 diabetes. The American Journal of Clinical Nutrition, 106(3), 888–894. https://doi.org/10.3945/ajcn.117.157107

Die Themen in den Wissensnachrichten: +++ Weiterer Ortsteil des untergegangenen Rungholt nachgewiesen +++ Interstellare Wolke könnte Eiszeit auf der Erde ausgelöst haben +++ Die Maya opferten wohl bevorzugt Brüderpaare +++**********Weiterführende Quellen zu dieser Folge:Weiterer Ortsteil von Rungholt nachgewiesen, Uni Kiel, 12.06.2024A possible direct exposure of the Earth to the cold dense interstellar medium 2–3 Myr ago, Nature Astronomy, 10.06.2024Ancient genomes reveal insights into ritual life at Chichén Itzá, Nature 12.06.2024Xylitol is prothrombotic and associated with cardiovascular risk, European Heart Journal, 06.06.2024Mehr als ein Viertel der 25-Jährigen wohnte 2023 noch im Haushalt der Eltern, Statistisches Bundesamt, 13.06.2024**********Ihr könnt uns auch auf diesen Kanälen folgen: Tiktok und Instagram.

Artificial sweeteners are now widely used to replace dietary sugars, and to sweeten various foods and drinks. Specifically, we're considering the sugar substitute Xylitol. Recently, researchers published some of their findings in the European Heart Journal, and the results suggest a link between Xylitol and various cardiovascular risks. Our medical columnist Doctor Peter Lin joined us this morning to help fill out the picture.

Doctor Peter Lin shares his reflections on new research about some artificial sweeteners. A study published last week in the European Heart Journal suggests a link to cardiovascular risks.

In this episode, Dr. Armstrong and Corbin Bruton discuss a recent study published in the European Heart Journal titled "Body Mass Index, Waist Circumference, and Mortality in Subjects Older than 80 Years: A Mendelian Randomization Study." The hosts uncover the surprising inverse relationship between BMI and all-cause/non-cardiovascular disease mortality, challenging conventional beliefs about weight and health outcomes in older adults and explore the implications of higher BMI and its protective effect on mortality and confront the paradoxical role of waist circumference as a significant risk factor for cardiovascular mortality. The hosts highlight the significance of factors like muscle mass, cognitive function, and overall health status for… aging well. Support the Show.Have questions you want answered and topics you want discussed on the Aging Well Podcast? Send us an email at agingwell.podcast@gmail.com or record your question for us to use in an upcoming episode:https://www.speakpipe.com/AgingWellPodcast

European Heart Journal, Volume 26, Issue 7, 2005, 650–661Background  Patients with diabetes have a higher risk of death after myocardial infarction than those without diabetes. There are many possible reasons for this difference. One may be that diabetic patients have detrimental responses during the acute phase of MI. In the DIGAMI 1 trial, patients with diabetes and AMI were randomized to intensive glucose control via IV insulin or standard care. Although the primary endpoint of all-cause mortality at 3 months was not statistically significant, the 1-year mortality was reduced by 30% in the IV-insulin group.  The DIGAMI 1 trial had lower than expected mortality which led to wide confidence intervals.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber.The hypothesis of the DIGAMI 2 trial was early and continued insulin-based metabolic control is a key to mortality reduction in patients with diabetes and AMI.Patients Eligible patients with type 2 diabetes or an admission blood glucose > 198 mg/dl who were admitted to participating CCU were eligible if they had suspected AMI due to symptoms (chest pain >15 min during the preceding 24 h) and/or recent ECG signs (new Q-waves and/or ST-segment deviations in two or more leads). Exclusion criteria were inability to cope with insulin treatment or to receive information on the study; residence outside the hospital catchment area; participation in other studies.Baseline Characteristics The trial recruited 1253 patients (mean age 68 years; 67% males) with type 2 diabetes and suspected acute myocardial infarction. At hospital discharge, approximately 85% of patients fulfilled the diagnosis of MI. Nearly half of these were STEMI. The remaining patients had unstable angina. The mean duration of diabetes was 8 years but about 20% of patients had diabetes of less than one year duration. Almost a third of patients had had a previous MI. Thirty percent of patients were on some form of insulin treatment before randomization. At randomization, HbA1c was 7.2, 7.3, and 7.3% in groups 1, 2, and 3, respectively.  The three groups were well matched in most respects, however, there were significantly fewer previous Mis and trend towards fewer patients with HTN, DM and HF in group 3.Evidence-based treatments for MI was extensive in all groups. Nearly all eligible patients had acute revascularization.Trial procedures DIGAMI 2 was carried out in 44 centers in Sweden, Finland, Norway, and Denmark. It had three treatment arms: a 24 h insulin–glucose infusion followed by a subcutaneous insulin-based long-term glucose control (group 1); a 24 h insulin–glucose infusion followed by standard glucose control (group 2), and, routine metabolic management according to local practice (group 3).The authors attempted to balance randomization and simulate the DIGAMI 1 trial by communicating baseline variables before randomization—which was based on an algorithm that included prognostic markers from the first DIGAMI trial. The goal was to improve the ability to compare the two DIGAMI trials. During the first 24 h, blood glucose was followed according to the infusion protocol in groups 1 and 2 and at the discretion of the attending physician in charge in group 3 (standard care).In groups 1 and 2, glucose-lowering treatment was initiated with a glucose–insulin infusion with the objective to decrease blood glucose as fast as possible and keep it between 126 and 180 mg/dl.  The infusion lasted until stable normoglycemia and at least for 24 h. In group 1, subcutaneous insulin was initiated at the cessation of the infusion. The treatment goal for patients in group 1 was a fasting blood glucose level of 90–126 mg/dl and a non-fasting level of

Die Themen in den Wissensnachrichten: +++ Grönland erhebt sich aus dem Meer +++ Frosch-Fossil: Tod bei der Paarung +++ Höheres Herz-Kreislauf-Risiko durch HPV +++**********Weiterführende Quellen zu dieser Folge:Vertical Land Motion Due To Present-Day Ice Loss From Greenland's and Canada's Peripheral Glaciers, Geophysical Research Letters, 13.1. 2024A cretaceous frog with eggs from northwestern China provides fossil evidence for sexual maturity preceding skeletal maturity in anurans, Proceedings of the Royal Society B ,7.2. 2024Human papillomavirus infection and cardiovascular mortality: a cohort study, European Heart Journal, 7.2. 2024Antler Allometry, the Irish Elk and Gould Revisited, Evolutionary Biology, 29.1. 2024Implicit racial biases are lower in more populous more diverse and less segregated US cities, Nature Communications, 6.2.2024Alle Quellen findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: Tiktok und Instagram.

LAAO, more evidence that stable CAD is stable, CRT benefit over the long-term, and AF monitoring after stroke are the topics John Mandrola, MD, covers in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. LAAO This Week in Cardiology Podcast, Dec 15, 2023 https://www.medscape.com/viewarticle/999282 European Heart Journal paper https://academic.oup.com/eurheartj/article/45/3/214/7471675 LAAOS 3 https://www.nejm.org/doi/full/10.1056/NEJMoa2101897 II. CAD after Transcatheter Aortic Valve Implantation Cleveland Clinic Observational study https://doi.org/10.1093/eurheartj/ehae019 ACTIVATION trial  https://doi.org/10.1016/j.jcin.2021.06.041 III. Cardiac Resynchronization Therapy Original RAFT 2010 https://www.nejm.org/doi/full/10.1056/nejmoa1009540 Long-term RAFT  https://www.nejm.org/doi/full/10.1056/NEJMoa2304542 Editorial https://www.nejm.org/doi/full/10.1056/NEJMe2312419 IV. AF Monitoring After Stroke Japanese Observational Study https://www.ahajournals.org/doi/10.1161/JAHA.123.031508 ARTESIA https://www.nejm.org/doi/full/10.1056/NEJMoa2310234 NOAH https://www.nejm.org/doi/full/10.1056/NEJMoa2303062 LOOP substudy https://jamanetwork.com/journals/jamaneurology/fullarticle/2795865 CRYSTAL AF https://www.nejm.org/doi/full/10.1056/nejmoa1313600 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Una ricerca a suo modo rivoluzionaria dimostra come anche piccoli cambiamenti nel nostro stile di vita possano avere un impatto significativo sulla salute del cuore. La ricerca, supportata dalla British Heart Foundation e pubblicata sul European Heart Journal, è stata condotta da un consorzio internazionale per valutare, per la prima volta, come diversi modelli di movimento nell'arco delle 24 ore siano collegati alla salute del cuore.

In today's episode we delve into the critical topic of responder wellbeing. We are joined by Matt Walton who offers insights into the psychological support often lacking in the field and the importance of acknowledging the impact of traumatic events on responders. Among the issues we'll be discussing are the prevalence of PTSD symptoms, the effects of night shifts, and the role of leadership in protecting mental health. Our guests also share personal experiences and provide valuable tips for preserving wellbeing amidst the stress of resuscitation efforts. Additionally, we explore the Resuscitation Council Wellbeing Resource, a comprehensive guide developed to support responders. So, join us as we navigate the complex world of responder wellbeing and delve into meaningful discussions that shed light on this critical aspect of emergency medicine. Matt is a Doctor working in A+E in Newcastle with an interest in pre-hospital care and wilderness medicine. Matt has focussed most of his medical career on promoting public campaigns to support frontline staff wellbeing and resilience. He studied medicine at Cambridge University and developed amateur filmmaking skills, subsequently creating a documentary on Responder Wellbeing for the BBC. He last spoke with WEM from the COVID front line in London following the release of an academic paper for the European Heart Journal guiding support for staff mental health. Matt has just led the creation of the first ever Resuscitation Council UK Responder Wellbeing Resource, which we will discuss in the podcast. Matt also instructs on the diploma in mountain medicine and the World Extreme Medicine Expedition & Wilderness medicine courses. He has recently travelled to high altitude with WEM and Bear Grylls to make a Netflix film.

Esta semana, primero comentaremos las recientes manifestaciones en París y en toda Francia, dedicadas a condenar el creciente antisemitismo que hay en el país. Los principales partidos políticos participaron en las protestas. A continuación, discutiremos la retórica y la esencia del discurso pronunciado recientemente por el expresidente Donald Trump durante el Día de los Veteranos. En el segmento de ciencia, discutiremos un estudio pionero publicado el 10 de noviembre en el European Heart Journal, que indica cómo sustituir actividades sedentarias por cualquier tipo de movimiento, incluso por el sueño, puede beneficiar considerablemente la salud. Y, para acabar, comentaremos la salida de los pandas gigantes del Zoo de Washington, lo cual simboliza el fin de la diplomacia del panda. En la segunda parte del programa, Trending in Spain, hablaremos de música y de pintura. En la primera noticia nos trasladamos a Sevilla, donde este año se celebra la gala de los Premios Grammy Latino. En la segunda noticia comentaremos la cara oculta de algunas obras de arte. Estas han sido minuciosamente escogidas para la exposición Reversos, en el Museo del Prado de Madrid. La ultraderecha francesa se une a la manifestación contra el antisemitismo, mientras que la extrema izquierda se niega La retórica política de Donald Trump refleja la retórica usada por los dictadores Hacer cualquier actividad, incluso dormir, es mejor para la salud que estar sentado Los pandas gigantes abandonan el Zoo de Washington, marcando el fin de la diplomacia del panda Premios Grammy Latino 2023 Exposición de la cara oculta de los cuadros

Wir beginnen unser heutiges Programm mit einer Diskussion über die Demonstrationen gegen den eskalierenden Antisemitismus in Frankreich, die letzte Woche in Paris und im ganzen Land stattfanden. Wichtige politische Parteien haben sich aktiv an diesen Protesten beteiligt. Danach sprechen wir über die Rhetorik und die Kernaussage einer Rede von Ex-Präsident Donald Trump zum Veterans Day. Im wissenschaftlichen Teil geht es um eine wegweisende Studie, die am 10. November im European Heart Journal veröffentlicht wurde. Sie zeigt, dass man seine Gesundheit deutlich verbessern kann, wenn man Sitzen durch jegliche Form der Bewegung ersetzt. Und zum Schluss sprechen wir über die Rücksendung der Pandas aus dem Zoo in Washington nach China, was das Ende der chinesisch-amerikanischen Panda-Diplomatie symbolisiert. Weiter geht es jetzt mit dem zweiten Teil unseres Programms „Trending in Germany“, wo wir heute über das „Deutschland-Barometer Depression 2023“ sprechen werden. Das ist ein Bericht, der Einsamkeit als eine neue Epidemie darstellt. Jeder vierte Erwachsene in Deutschland leidet unter tiefen Gefühlen der Isolation. Wir werden außerdem das Thema Schulzeit diskutieren. Die meisten Schülerinnen und Schüler beginnen morgens um 7:30 Uhr mit dem Unterricht. Studien zeigen jedoch, dass dieser frühe Beginn nicht dem natürlichen Schlafrhythmus junger Menschen entspricht. Deshalb wird immer wieder über die Möglichkeit diskutiert, den Unterricht später zu beginnen. Frankreichs extreme Rechte demonstrieren gegen Antisemitismus, die Linke ist nicht dabei Die politische Rhetorik von Donald Trump erinnert an faschistische Diktatoren Jede Art von Aktivität, selbst Schlafen, ist besser für die Gesundheit als Sitzen Ende der Panda-Diplomatie: Pandas verlassen den Zoo in Washington Jeder vierte Erwachsene in Deutschland extrem einsam Hat Morgenstund Gold im Mund?

Welcome to the Olink® Proteomics in Proximity podcast! Below are some useful resources mentioned in this episode: Olink tools and software• Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/• Olink® Explore HT, Olink's most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity: https://olink.com/products-services/exploreht/ UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world's largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies Research articles• Dhindsa, R.S., Burren, O.S., Sun, B.B. et al. Rare variant associations with plasma protein levels in the UK Biobank. 2023 Nature, DOI: 10.1038/s41586-023-06547-xhttps://www.nature.com/articles/s41586-023-06547-x• Sun, B.B., Chiou, J., Traylor, M. et al.  Plasma proteomic associations with genetics and health in the UK Biobank. 2023 Nature, DOI: 10.1038/s41586-023-06592-6 https://www.nature.com/articles/s41586-023-06592-6• Ticau S, Sridharan G, Tsour S, et al. Neurofilament Light Chain as a Biomarker of Hereditary Transthyretin-Mediated Amyloidosis 2021 Neurology, DOI: 10.1212/WNL.0000000000011090https://n.neurology.org/content/96/3/e412.long• Zannad F, Ferreira JP, Butler J, et al.  Effect of Empagliflozin on Circulating Proteomics in Heart Failure: Mechanistic Insights from the EMPEROR Program. 2022 European Heart Journal, DOI: 10.1093/eurheartj/ehac495                https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehac495/6676779• Eldjarn GH, et al. Large-scale plasma proteomics comparisons through genetics and disease associations. Nature. 2023 Oct;622(7982):348-358. doi: 10.1038/s41586-023-06563-xhttps://www.nature.com/articles/s41586-023-06563-x#Sec44• [PREPRINT] Carrasco-Zanini et al 2023 Proteomic prediction of common and rare diseases MedRxiv https://www.medrxiv.org/content/10.1101/2023.07.18.23292811v1• Michaëlsson E, Lund LH, Hage C, et al. Myeloperoxidase Inhibition Reverses Biomarker Profiles Associated With Clinical Outcomes in HFpEF. 2023 JACC. Heart Failure, DOI: 10.1016/j.jchf.2023.03.002https://www.sciencedirect.com/science/article/pii/S2213177923001257• Girerd N, Levy D, Duarte K, et al.  Protein Biomarkers of New-Onset Heart Failure: Insights From the Heart Omics and Ageing Cohort, the Atherosclerosis Risk in Communities Study, and the Framingham Heart Study. 2023 Circulation Heart Failure, DOI: 10.1161/CIRCHEARTFAILURE.122.009694https://www.ahajournals.org/doi/abs/10.1161/CIRCHEARTFAILURE.122.009694Subscribe to the podcast on your favorite player or app:Apple Podcasts: https://apple.co/3T0YbSm Spotify Podcasts: https://open.spotify.com/show/2sZ2wxO... Google Podcasts: https://podcasts.google.com/feed/aHR0... Amazon Music: https://music.amazon.com/podcasts/d97... Podcast Addict: https://podcastaddict.com/podcast/409... Deezer: https://www.deezer.com/show/5178787 Player FM: https://player.fm/series/series-3396598 In case you were wondering, Proteomics in Proximity refers to the principle underlying Olink technology called the Proximity Extension Assay (PEA). More information about the assay and how it works can be found here: https://bit.ly/3Rt7YiY For any questions regarding information about Olink Proteomics, please email us at info@olink.com or visit our website: https://www.olink.com/Interested in a specific podcast topic or guest? Reach out to us at PIP@olink.comWHAT IS PROTEOMICS IN PROXIMITY?Proteomics in Proximity discusses the intersection of proteomics with genomics for drug target discovery, the application of proteomics to reveal disease biomarkers, and current trends in using proteomics to unlock biological mechanisms. Co-hosted by Olink's Cindy Lawley and Sarantis Chlamydas.

Wir beginnen unser heutiges Programm mit einer Diskussion über die Demonstrationen gegen den eskalierenden Antisemitismus in Frankreich, die letzte Woche in Paris und im ganzen Land stattfanden. Wichtige politische Parteien haben sich aktiv an diesen Protesten beteiligt. Danach sprechen wir über die Rhetorik und die Kernaussage einer Rede von Ex-Präsident Donald Trump zum Veterans Day. Im wissenschaftlichen Teil geht es um eine wegweisende Studie, die am 10. November im European Heart Journal veröffentlicht wurde. Sie zeigt, dass man seine Gesundheit deutlich verbessern kann, wenn man Sitzen durch jegliche Form der Bewegung ersetzt. Und zum Schluss sprechen wir über die Rücksendung der Pandas aus dem Zoo in Washington nach China, was das Ende der chinesisch-amerikanischen Panda-Diplomatie symbolisiert. Weiter geht es jetzt mit dem zweiten Teil unseres Programms „Trending in Germany“, wo wir heute über das „Deutschland-Barometer Depression 2023“ sprechen werden. Das ist ein Bericht, der Einsamkeit als eine neue Epidemie darstellt. Jeder vierte Erwachsene in Deutschland leidet unter tiefen Gefühlen der Isolation. Wir werden außerdem das Thema Schulzeit diskutieren. Die meisten Schülerinnen und Schüler beginnen morgens um 7:30 Uhr mit dem Unterricht. Studien zeigen jedoch, dass dieser frühe Beginn nicht dem natürlichen Schlafrhythmus junger Menschen entspricht. Deshalb wird immer wieder über die Möglichkeit diskutiert, den Unterricht später zu beginnen. Frankreichs extreme Rechte demonstrieren gegen Antisemitismus, die Linke ist nicht dabei Die politische Rhetorik von Donald Trump erinnert an faschistische Diktatoren Jede Art von Aktivität, selbst Schlafen, ist besser für die Gesundheit als Sitzen Ende der Panda-Diplomatie: Pandas verlassen den Zoo in Washington Jeder vierte Erwachsene in Deutschland extrem einsam Hat Morgenstund Gold im Mund?

Whole-fat dairy is bad for our health. Switch to skim milk or an alternative like almond milk. This is what we have been told for decades by nutritionists and doctors. A recent paper in the European Heart Journal, “Diet, cardiovascular disease, and mortalities in 80 countries”, however, suggests that whole-fat dairy might be a protective food. The authors, Andrew Mente et al., concluded that “a diet comprised of higher amounts of fruits, vegetables, nuts, legumes, fish, and whole-fat dairy is associated with lower [cardiovascular disease] and mortality in all world regions, especially in countries with lower income where consumption of these foods is low.” In this episode, we discuss dairy foods and the challenges seniors may face that can make it difficult for them to maintain a healthy diet for… aging well. See also:"PURE Healthy Diet Sees Advantage by Promoting Whole-Fat Dairy for Heart Health"Support the showHave questions you want answered and topics you want discussed on "Aging Well"? Send us an email at agingwell.podcast@gmail.com or record your question for us to use in an upcoming episode:https://www.speakpipe.com/AgingWellPodcast

Joanne e Fred discutem sobre o manejo de medicações no perioperatório, com foco em anti-hipertensivos e antidiabéticos - quando suspender e quando manter? Referências: 1. ESC Scientific Document Group , 2022 ESC Guidelines on cardiovascular assessment and management of patients undergoing non-cardiac surgery: Developed by the task force for cardiovascular assessment and management of patients undergoing non-cardiac surgery of the European Society of Cardiology (ESC) Endorsed by the European Society of Anaesthesiology and Intensive Care (ESAIC), European Heart Journal, Volume 43, Issue 39, 14 October 2022, Pages 3826–3924. 2. Gualandro DM, Yu PC, Caramelli B, Marques AC, Calderaro D, Fornari LS, Pinho C, et al. 3ª Diretriz de Avaliação Cardiovascular Perioperatória da Sociedade Brasileira de Cardiologia. Arq. Bras. Cardiol. 2017;109(3 suppl 1):1-104. 3. Himes CP, Ganesh R, Wight EC, Simha V, Liebow M. Perioperative Evaluation and Management of Endocrine Disorders. Mayo Clin Proc. 2020 Dec;95(12):2760-2774.

What can be done to improve our memories as we grow older? The latest longevity science suggests help could be on the way. There's also a new drug that appears to slow the progress of Alzheimer's disease, and researchers highlight what they believe to an optimum diet for longevity.Peter Allison and Peter Bowes – school friends in North East England 50 years ago – return with another conversation about the latest science that could help us achieve a longer healthspan.Topics covered in this conversation include·      The importance of memory and concerns about forgetfulness as people age.·      A study published in the European Heart Journal highlights the benefits of a healthy diet, particularly one that includes fruits, nuts, legumes, fish, and dairy.·      The study suggests that focusing on consuming protective foods rather than avoiding damaging foods may lead to better health outcomes.·      Peter and Peter discuss their own experiences with diet and how it has changed over time.·      A study in monkeys that demonstrates the cognitive benefits of the protein klotho, which is associated with lower levels in people with dementia.·      The study shows promising results in improving cognitive abilities in the monkeys, but further research in humans is needed.·      Another study highlights a new drug that shows potential in treating Alzheimer's disease by reducing brain plaque.·      The drug has shown to slow cognitive decline by one-third in human studies, but it also has potential side effects.·      The discussion touches on the financial aspects of research in dementia and Alzheimer's, as there is a growing need for effective treatments.·      The importance of collaboration and social interaction for mental health and cognitive abilities is emphasized, particularly in the context of the COVID-19 pandemic.FlexBeam red light therapyRecharge Health is offering LLAMA listeners an $80.00 discount on the purchase of FlexBeam, the wearable red light therapy device which targets key parts of the body. Use code LLAMA▸ DISCLOSURE: LLAMA derives a small commission from affiliate links here. It helps in our mission to share conversations, free of charge, about human longevity. Affiliation disclosure: This site includes affiliate links from which we derive a small commission, if you click on the product links and use the code LLAMA at checkout. This helps support the channel and allows us to continue sharing conversations like this. LLAMA is available, free of charge, wherever you get your podcasts. Our mission is to explore the science and lifestyle interventions that could help us live longer and better. Thank you for the support!Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Prashanthan Sanders, MBBS, PhD, FHRS of the University of Adelaide discusses a worldwide survey on incidence, management, and prognosis of oesophageal fistula formation following atrial fibrillation catheter ablation: the POTTER-AF study. This study recently appeared in the European Heart Journal. He is joined by guests Jonathan P. Piccini, Sr., MD, MHS, FHRS of Duke Medical Center and Han S. Lim, MBBS, PhD, FHRS of the University of Melbourne. https://www.hrsonline.org/education/TheLead Host Disclosure(s): P. Sanders: Research (Contracted Grants for PIs Named Investigators Only): Boston Scientific, Abbott, Medtronic, PaceMate, Becton Dickinson, CathRx; Advisory Committee Membership: Medtronic, Boston Scientific, PaceMate, CathRx   Contributor Disclosure(s): J. Piccini: Honoraria/Speaking/Consulting Fee: Biotronik, AbbVie, LivaNova, Boston Scientific, Phillips, Medtronic, Electrophysiology, Frontiers, Abbott, UpToDate, Inc., Sanofi, Milestone Pharmaceuticals, Bayer Healthcare Pharmaceuticals; Research (Contracted Grants for PIs Named Investigators Only): Boston Scientific, Bayer Healthcare Pharmaceuticals, AMA, Abbott, Phillips, Element Science, Inc., iRhythm Technologies, NIH H. Lim: No relevant financial relationships with ineligible companies to disclose. 

Neste episodio, cito um artigo recém publicado sobre alimentos que podem diminuir nosso risco de doenças cardiovasculares. Lembrando que 18 milhões de pessoas morrem por ano do coração. Se pudermos diminuir nosso risco, pq não?! Referência: Andrew Mente and others, Diet, cardiovascular disease, and mortality in 80 countries, European Heart Journal, 2023;, ehad269, https://doi.org/10.1093/eurheartj/ehad269

This week on Surfing NASH, co-hosts Jörn Schattenberg and Roger Green review the recently concluded Liver Forum. Joining discussion are Liver Forum Executive Director Veronica Miller and speakers Mazen Noureddin (Houston Research Institute), Michelle Long (Novo Nordisk) and Jeff McIntyre (Global Liver Institute).Roger leads this conversation by asking the panelists to pick a particular session that captured their attention in a way that could not have been predicted. Michelle first mentions how the agenda as a whole illuminated the depth of the issues surrounding drug development for the fatty liver field. Veronica points to an interactive session titled NASH Drug Development in the Era of Approved Drugs, commending friends of the podcast Manal Abdelmalek and Pamela Danagher for their brilliant moderation. She says that hosting an unscripted panel in a safe environment with engaged participants is a way to “push the envelope and move the field forward.” Jörn notes data presented from the European Heart Journal as an exciting example of exploring and utilizing literature from outside the liver field. At this point, Mazen offers a more tangible description of some content covered. He details general concepts behind a session on Cirrhosis Working Group Updates which included his presentation on Compensated Cirrhosis Risk Stratification. As the conversation winds down, Veronica reminds that the slides from the event are published on the Liver Forum website and well worth a review. If you enjoy the episode, have questions or interest around its contents and Fatty Liver disease, we kindly ask that you submit reviews wherever you download our discussions. Alternatively, you can write to us directly at questions@SurfingNASH.com.Stay Safe and Surf On!

Discover the surprising findings of the Master@Heart study, which reveals a potential link between intensive endurance exercise and increased coronary plaque risk. Learn what this means for your health.References:-Mandsager K, Harb S, Cremer P, Phelan D, Nissen SE, Jaber W. Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing. JAMA Netw Open. 2018;1(6):e183605. doi:10.1001/jamanetworkopen.2018.3605-Bosscher et al. Master@Heart Consortium, Lifelong endurance exercise and its relation with coronary atherosclerosis, European Heart Journal, 2023;, ehad152, https://doi.org/10.1093/eurheartj/ehad152VISIT OUR STOREStore: https://www.selfelements.comFOLLOW USwww.selfprinciple.orgwww. youtube.com/selfprinciplewww.youtube.com/plantbasedkidneyhealthwww.instagram.com/seanhashmimd

This week on Surfing NASH, co-hosts Jörn Schattenberg and Roger Green review the recently concluded Liver Forum. Joining discussion are Liver Forum Executive Director Veronica Miller and speakers Mazen Noureddin (Houston Research Institute), Michelle Long (Novo Nordisk) and Jeff McIntyre (Global Liver Institute). This integrative meeting aims to advance the regulatory sciences for the treatment of NAFLD/NASH and liver fibrosis by providing an independent and neutral venue for ongoing multi-stakeholder dialogue. The resulting conversations facilitate making the best science-based decisions on how to study efficacy and safety in real time as collective knowledge and experience with therapies for liver diseases develops. This year's meeting proved particularly stimulating in light of imminent drug approvals.What is The Liver Forum and First Impressions from The MeetingVeronica underscores the importance of being able to convene as a community to make advances in how drugs get researched and approved, and how patients participate in this ongoing process. Jeff notes benefits around increasing patient involvement in multiple panels with each successive year. Michelle reminds that “at the end of the day, it's about making people feel, function and survive better.” She notes that from the patient perspective, halting progression and stabilizing disease are significant quality of life components for treating NASH - a message which could see more amplification. Jörn describes how the energies of the meeting carried through to Europe where he was participating remotely. Roger, who also attended remotely, comments positively on the cohesiveness of the program. Finally, Mazen introduces specific topics explored, namely cirrhosis, the future of combination therapy and clinical trial design.Panelists Select Sessions of InterestEach share takeaways around specific sessions that captured their attention in a way that could not have been predicted. Michelle mentions how the agenda as a whole illuminated the depth of the issues surrounding drug development for the fatty liver field. Veronica points to an interactive session titled NASH Drug Development in the Era of Approved Drugs, commending the moderators and friends of the podcast Manal Abdelmalek and Pamela Danagher. She says that hosting an unscripted panel in a safe environment with brilliant participants is a way to “push the envelope and move the field forward.” Jörn notes data presented from the European Heart Journal as an exciting example of exploring and utilizing literature from outside the liver field. Mazen elaborates on scientific concepts distilled from a session on cirrhosis.Session VIII: Stretch Exercise: New Look at StatisticsVeronica describes a session dedicated to statistics and being impressed with how well it played out. In agreement, both Roger and Jeff share different perspectives as to how the session succeeded. Scott Evans of George Washington University opened with Desirability of Outcome Ranking (DOOR) Analysis. Lauren Dang of UC Berkeley followed with her talk, Hybrid Randomized/Real-World Data Designs: A Case Study of Semaglutide and Cardiovascular Outcomes. Closing CommentsAs the session winds down, the group describes takeaways that might appear in the soon-to-be published slides from the meeting. If you enjoy the episode, have questions or interest around the Liver Forum and Fatty Liver disease, we kindly ask that you submit reviews wherever you download our discussions. Alternatively, you can write to us directly at questions@SurfingNASH.com.Stay Safe and Surf On!

Full Podcast Transcript at treesmendus.com Books written by podcast host Verla Fortier:Optimize Your Heart Rate: Balance Your Mind and Body With Green Space Take Back Your Outside Mindset: Live Longer, Stress  Less, and Control Your Chronic Illness Dr. Patrycja Matusik is a physician-radiologist at University Hospital, Kraków, Poland. She completed her medicine degree and PhD at Jagiellonian University in Kraków. In her work she focuses primarily on cardiovascular imaging, lung diseases and neuroimaging.In her scientific work, one of the main directions is heart rate variability (HRV). She went to the Cardiovascular Division at the Department of Medicine at Washington University School of Medicine in St. Louis, Missouri, USA on two occasions. There she completed internships in the field of advanced methods of ECG analysis under the mentorship of Prof. Phyllis K. Stein in the Heart Rate Variability Laboratory. She is the co-author of several scientific papers published in peer-reviewed international journals, including the European Heart Journal. 1.    Please tell us a little more about your personal - why you are interested in lupus erythematosus.  First, I want to say thank you for inviting me to your podcast.As you said I'm a physician radiologist from Poland. Privately, I'm a mother of 3-year-old Julia. My husband, Paweł Matusik, is also a doctor – a cardiologist, and together we combine our passion for scientific research.  I was inspired by lupus for the first time on my internship at the Heart Rate Variability Laboratory led by Prof. Phyllis K. Stein at Washington University in St. Louis. During the course of lupus, involvement of multiple organ systems, including the cardiovascular and autonomic nervous system, occurs. Therefore, we decided to bring together and summarize current knowledge about the scientific findings and potential clinical utility of heart rate variability measures in patients with systemic lupus erythematosus. 2.     Please tell us what lupus erythematosus is and what can happen during the disease process as it relates to your publication “ Heart Rate Variability in patients with systemic lupus erythematosus: a systematic review and methodological considerations.”  Systemic lupus erythematosus is a chronicFor peer reviewed research on how your time spent in green space can change your mindset, balance your nervous system and your heart rate please go to my website https://treesmendus.com and check out my books Take Back Your Outside Mindset: Live Longer, Stress Less, and Control Your Chronic Illness and Optimize Your Heart Rate: Balance Your Mind and Body With Green Space

“The Science™” says: Inject elite athletes to save their lives. Block the Sun to save the children. Shut-down the hospitals to “flatten the curve.THE THESIS: The World's technocrats think they are gods. Their hubris is deadly and we must confront them.THE SCRIPTURE & SCRIPTURAL RESOURCES: Ezekiel 28:2“Son of man, say to the leader of Tyre, ‘Thus says the Lord God,“Because your heart is lifted upAnd you have said, ‘I am a god,I sit in the seat of godsIn the heart of the seas';Yet you are a man and not God,THE NEWS & COMMENT:The Preface . . . For 30 years, this man has been wrong about the predictions he's made in his books. Still, 60 Minutes treats him as believable. [AUDIO] - “The next few decades will be the end of the kind of civilization we're used to.” Humanity is consuming 175 percent of what the earth can regenerate. Biologist Paul Erlich says that our current way of life is unsustainable.The teaser . . .From Natural News: After DECADES of denial, corporate media admits chemtrail terraforming is happening right now to “fight climate change” . . . but, that's “just ‘Natural News' saying that . . . The focus . . . Bills safety Damar Hamlin was taken off of the field in an ambulance after collapsing mid game. Prior to 2021, Athletes collapsing on the field was NOT a normal event.Berenson: The spin is already starting. Commotio cordis? Commotio cordis is incredibly rare and happens when a ball hits a skinny 15-year-old in the chest. This is going to be a very big deal - and the media and league will do whatever they can to avoid the obvious question…More Berenson: Update on the Damar Hamlin pieceA reader pointed me to this striking 2021 paper in the European Heart Journal reporting on two cases in which rugby players suffered severe heart rhythm disturbances following blunt chest trauma. In both cases the men had histories of myocarditis which appeared to have caused or worsened the arrhythmias. In the second case, the myocarditis was undiagnosed; the player died.The authors found that the episodes could be distinguished from classic commotio cordis (trauma to the chest wall causing a sudden heart rhythm crisis) by underlying myocardial scarring. They concluded that the aftereffects of myocarditis raise “the risk of lethal ventricular arrhythmias following blunt chest trauma.”1,616 Athlete Cardiac Arrests, Serious Issues, 1,114 of Them Dead, Since COVID Injection[AUDIO] - Holy smokes… Dr. McCullough claims 1,598 suffered cardiac arrest since vaccination compared to 1,101 in prior 38 YEARS…From Died Suddenly on Twitter: BBC News reached out for comment from #DiedSuddenly Tonight. Here was our response. We've also included the archive of evidence that the media is trying to gaslight you into ignoring. Never let them tell you what you're seeing isn't real. Here's the database they sent the BBC: https://airtable.com/shrbaT4x8LG8EbvVG/tbl7xKsSUIOPAa7MxIt's not just athletes . . . ‘Died Suddenly'? More Than 1-in-4 Think Someone They Know Died From COVID-19 VaccinesLawmakers in other countries are beginning to tell the truth! [AUDIO] - 'This is the time to draw a line in the sand... Common sense tells you there's something not right about all of this.' Andrew Bridgen MP joins Mark Dolan to discuss why he's calling on the Government to suspend the rollout of the Covid-19 vaccines.. . . and the ruin the technocrats laid on the “healthcare” system is having the easily predictable outcome. [AUDIO] - Dr Tim Cooksley tells Sky News that the NHS is under the most pressure it has ever experienced, including during the peak of the COVID pandemic.[AUDIO] - Royal College of Emergency Medicine, Ian Higgison: An emergency medicine spokesperson tells Sky News that pressures on emergency services are so great that effective treatment is not possible.”[AUDIO] - France… Doctors throw down their stethoscopes in protest of a failed health system… this is a global problem from not treating patients during covid. Now hospitals worldwide can not cope with the backlogWhich brings us back to these two stories. This man hates human life. Just like so many other technocrats, we is saying that either we need “five earths” or we need to see 7.5 billion people die. On CBS "60 Minutes" w/ @ScottPelley last night, @PaulREhrlich claimed a) humans are causing a "sixth mass extinction" & b) that it would require "five Earths" for all humans to enjoy a Western standard of living. Both claims are totally & utterly false.This company has decided God was wrong when he said “Let there be light.” From MIT Tech Review: A startup says it's begun releasing particles into the atmosphere, in an effort to tweak the climate; Make Sunsets is already attempting to earn revenue for geoengineering, a move likely to provoke widespread criticism.

It has been consistently shown in research that elevated dietary sodium consumption is associated with high blood pressure and an increased risk of cardiovascular disease. In addition, low levels of dietary potassium intake are associated with these same risks. However, there is some debate on how to characterize these relationships. In a study published in European Heart Journal in July 2022, using data from the EPIC-Norfolk study, researchers attempted to answer whether the associations between potassium and both blood pressure and cardiovascular disease: 1) differ between men and women? and 2) depend on daily sodium intake. In this episode Dr. Alan Flanagan and Danny Lennon discuss the details of this study and then link it to the overall evidence base and what this may mean for potassium (and sodium) intake considerations. Access show notes Subscribe to Premium

A new study has found that potassium-rich diets were associated with lower blood pressure, particularly in women with high salt intake. Three specific foods had the most benefit. Listen in this week as Dee discusses the research, and why a high potassium diet is important for everyone.Reference:Wouda, R. D., Boekholdt, S. M., Khaw, K. T., Wareham, N. J., de Borst, M. H., Hoorn, E. J., Rotmans, J. I., & Vogt, L. (2022). Sex-specific associations between potassium intake, blood pressure, and cardiovascular outcomes: the EPIC-Norfolk study. European Heart Journal, ehac313. https://doi.org/10.1093/eurheartj/ehac313

Ancient cultures all over the world used the pulse as a diagnostic tool. And eventually, we figured out how to measure blood pressure, and hypertension came to be viewed as a disease. Research: Booth, Jeremy. “A Short History of Blood Pressure Measurement.” Proceedings of the Royal Society of Medicine. Vol. 70. Nov. 1977. https://journals.sagepub.com/doi/pdf/10.1177/003591577707001112 Elias, Merrill F. and Amanda L. Goodell. “Setting the record straight for two heroes in hypertension: John J. Hay and Paul Dudley White.” Journal of Clinical Hypertension. 9/21/2019. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8030549/#jch13650-bib-0004 Greene, Jeremy A. “Releasing the Flood Waters: Diruil and the Reshaping of Hypertension.” Bulletin of the History of Medicine, Vol. 79, No. 4, Winter 2005. https://doi.org/10.1353/bhm.2005.0153 Harold, John Gordon. “Harold on History | Historical Perspectives on Hypertension.” American College of Cardiology. 11/20/2017. https://www.acc.org/latest-in-cardiology/articles/2017/11/14/14/42/harold-on-history-historical-perspectives-on-hypertension Hay, John. “The Significance of a Raised Blood Pressure.” British Medical Journal. 7/11/1931. Johnson, Richard J. et al. “The discovery of hypertension: evolving views on the role of the kidneys, and current hot topics.” Renal Physiology. 1/2/2015. https://doi.org/10.1152/ajprenal.00503.2014 Kotchen, Theodore A. “Historical Trends and Milestones in Hypertension Research: A Model of the Process of Translational Research.” Hypertension. Vol. 58, 2011.  https://doi.org/10.1161/HYPERTENSIONAHA.111.177766 Labos, Christopher. “The Current Hypertension Controversy: There is None..” McGill. 2/8/2018. https://www.mcgill.ca/oss/article/general-science/current-hypertension-controversy-there-none Lüscher, Thomas F. “High blood pressure: new frontiers of an old risk factor.” European Heart Journal (2017) 38, 2791–2794. doi:10.1093/eurheartj/ehx544 Moser, Marvin. “Historical Perspectives on the Management of Hypertension.” Journal of Clinical Hypertension. 5/22/2007. https://doi.org/10.1111/j.1524-6175.2006.05836.x Postel-Vinay, Nicolas, editor. “A Century of Arterial Hypertension 1896-1996.” Wiley. 1996. Saklayen, Mohammad G. and Neeraj V. Deshpande. “Timeline of History of Hypertension Treatment.” Frontiers in Cardiovascular Medicine. 2/23/2016. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763852/ See omnystudio.com/listener for privacy information.

Clips : Gravitas Plus: The truth behind preserved and processed food Articles: Australia: The More “Vaccines” You've Had, The Sicker You'll Be Could certain COVID-19 vaccines leave people more vulnerable to the AIDS virus? NATIONAL PEACE RALLY BLACKLISTED BY MAINSTREAM AND SOCIAL MEDIA HEALTH NEWS: Green tea extract promotes gut health, lowers blood sugar Ohio State University, July 26, 2022New research in people with a cluster of heart disease risk factors has shown that consuming green tea extract for four weeks can reduce blood sugar levels and improve gut health by lowering inflammation and decreasing “leaky gut.”Researchers said this is the first study assessing whether the health risks linked to the condition known as metabolic syndrome, which affects about one-third of Americans, may be diminished by green tea's anti-inflammatory benefits in the gut.”There is much evidence that greater consumption of green tea is associated with good levels of cholesterol, glucose and triglycerides, but no studies have linked its benefits at the gut to those health factors,” said Richard Bruno, senior study author and professor of human nutrition at The Ohio State University.In the new study, green tea extract also lowered blood sugar, or glucose, and decreased gut inflammation and permeability in healthy people—an unexpected finding. “What this tells us is that within one month we're able to lower blood glucose in both people with metabolic syndrome and healthy people, and the lowering of bloodglucose appears to be related to decreasing leaky gut and decreasing gut inflammation—regardless of health status,” Bruno said.”We did not attempt to cure metabolic syndrome with a one-month study,” he said. “But based on what we know about the causal factors behind metabolic syndrome, there is potential for green tea to be acting at least in part at the gut level to alleviate the risk for either developing it or reversing it if you already have metabolic syndrome.” Blood vessels can actually get better with age  Study finds that arteries adapt to oxidative stress caused by agingUniversity of Missouri, July 21, 2022Although the causes of many age-related diseases remain unknown, oxidative stress is thought to be the main culprit. Oxidative stress has been linked to cardiovascular and neurodegenerative diseases including diabetes, hypertension and age-related cancers. However, researchers at the University of Missouri found that aging actually offered significant protection against oxidative stress. These findings suggest that aging may trigger an adaptive response to counteract the effects of oxidative stress on blood vessels.”Molecules known as reactive oxygen species, or ROS, play an important role in regulating cellular function,” said Steven Segal, a professor of medical pharmacology and physiology at the MU School of Medicine and senior author of the study. “However, the overproduction of ROS can help create a condition referred to as oxidative stress, which can alter the function of cells and interfere with their growth and reproduction.””We studied the endothelium from resistance arteries of male mice at 4 months and 24 months of age, which correspond to humans in their early 20s and mid-60s,” Segal said. “We first studied the endothelium under resting conditions and in the absence of oxidative stress. We then simulated oxidative stress by adding hydrogen peroxide. When oxidative stress was induced for 20 minutes, the endothelial cells of the younger mice had abnormal increases in calcium when compared to the endothelial cells of the older mice. This finding is important because when calcium gets too high, cells can be severely damaged.”  When oxidative stress was extended to 60 minutes, Segal's team found that the death of endothelial cells in the younger mice was seven times greater than those from the older mice. These findings indicated that with advancing age, the endothelium had adapted to preserve cellular integrity when confronted with oxidative stress.Our study suggests that blood vessels adapt during the aging process to regulate ROS and minimize cell death when subjected to an abrupt increase in oxidative stress. This adaptation helps to ensure that the arteries of older individuals can still do their jobs.”  Elevated tween screen time linked to disruptive behavior disorders University of California, San Francisco, July 26, 2022Tweens who spend more time on screens have a higher likelihood of developing disruptive behavior disorders, with social media having an especially strong influence, a new UC San Francisco-led study published in the Journal of Child Psychology and Psychiatry found.Social media use was most likely to be linked to conduct disorder, while other forms of screen use—such as watching videos and television, playing video games, and texting—were more likely to be associated with oppositional defiant disorder (ODD).Conduct disorder is characterized by violating others' basic rights or societal rules with actions such as bullying, vandalism and stealing, while ODD is marked by a pattern of angry or irritable mood, argumentative or defiant behavior, and vindictiveness.Researchers collected data on screen use, then evaluated for behavior disorders one year later. Each hour of social media was linked with a 62% higher prevalence of conduct disorder, while television, video games, video chat, and texting were linked with a 14% to 21% higher prevalence of ODD.In another recent study, Nagata and colleagues found that adolescents are so attached to their phones—the main vehicle for screen time—that they report losing track of time when using their phone (47.5%) and will interrupt whatever they are doing when contacted by phone (31%).The average amount of screen time was four hours per day, with the most time spent watching/streaming TV shows/movies (1.3 hours on average), playing videogames (1.1 hours), and watching/streaming videos (1 hour).  In fact, four hours a day was a threshold, with time above four hours associated with a 69% higher prevalence of conduct disorder and a 46% higher prevalence of ODD. Cocoa shown to reduce blood pressure and arterial stiffness in study University of Surrey (UK), July 26, 2022 Cocoa flavanols have previously been found to lower blood pressure and arterial stiffnessas much as some blood pressure medication. However, how effective flavanols are in everyday life in reducing blood pressure has remained unknown, as previous studies in this area have been performed in tightly controlled experimental settings. Surrey's new research reduces concerns that cocoa as a treatment for raised blood pressure could pose health risks by decreasing blood pressure when it is not raised, paving the way for it to be potentially used in clinical practice. In the first study of its kind study, researchers set out to investigate the use of flavanols, a compound found in cocoa, in lowering blood pressure and arterial stiffness in individuals outside of clinical settings. For several days, eleven healthy participants consumed, on alternating days, either six cocoa flavanol capsules or six placebo capsules containing brown sugar. Participants were provided with an upper arm blood pressure monitor and a finger clip measuring pulse wave velocity (PWV) which gauges levels of arterial stiffness. Measurements of blood pressure and PWV were taken prior to consumption of the capsules and every 30 minutes after ingestion for the first three hours, and then hourly for the remaining nine hours. Researchers found that blood pressure and arterial stiffness were only lowered in participants if it was high, and there was no effect when the blood pressure was low in the morning. Professor Heiss added, “The positive impact cocoa flavanols have on our cardiovascular system, in particular, blood vessel function and blood pressure, is undeniable. Doctors often fear that some blood pressure tablets can decrease the blood pressure too much on some days. Greater potassium intake linked to lower blood pressure in women Amsterdam University Medical Center, July 25 2022.  A study  in European Heart Journal found an association between consuming a higher amount of potassium and lower blood pressure among women with a high intake of sodium. “It is well known that high salt consumption is associated with elevated blood pressure and a raised risk of heart attacks and strokes,” noted study author Liffert Vogt, MD, PhD, of Amsterdam University Medical Center. “Health advice has focused on limiting salt intake but this is difficult to achieve when our diets include processed foods. Potassium helps the body excrete more sodium in the urine.” The study included 11,267 men and 13,696 women who enrolled in England's EPIC-Norfolk study between 1993 and 1997. Some participants were being treated for hypertension. Sodium and potassium intake were estimated from urinary levels of these minerals and categorized as low, medium or high.  Increased potassium intake was associated with declining blood pressure among women with high sodium intake. In this group, each 1 gram increase in potassium consumption was associated with a 2.4 mmHg decrease in systolic blood pressure.  During a median follow-up of 19.5 years, 54.5% of the men and women experienced cardiovascular disease events. Men whose potassium intake was among the top one-third of participants had a 7% lower risk of hospitalization or death caused by cardiovascular disease compared to men whose intake was among the lowest third. Among women whose potassium intake was highest, the risk was 11% lower.  Elderberry benefits air travelers  Griffith University, July 21, 2022 The negative health effects of international air travel are well documented but now it seems that the common elderberry can provide some relief. Associate Professor Evelin Tiralongo and Dr Shirley Wee from Griffith's Menzies Health Institute Queensland (MHIQ) have completed a clinical trial showing that an elderberry supplement can provide some protection from cold and flu-like symptoms following long-haul flights. Intercontinental air travel can be stressful and affect a passenger's physical and psychological wellbeing. Whilst jet lag and fatigue remain the best known problems, holidaymakers also often experience upper respiratory symptoms. The randomised, double-blind placebo controlled clinical trial was conducted with 312 economy class passengers travelling from Australia to an overseas destination. Cold episodes, cold duration and symptoms were recorded in a daily diary and participants also completed surveys before, during and after travel. “We found that most cold episodes occurred in the placebo group. However, the placebo group had a significantly higher number of cold episode days, and the symptom score in the placebo group over these days was also significantly higher,” says Associate Professor Tiralongo. The trial used capsules containing 300mg of a standardised, proprietary membrane-filtered elderberry extract which has shown to be effective in working against respiratory bacteria and influenza viruses.

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-276 Overview: The concerns over the use of NSAIDs have been well documented. The medications can raise blood pressure and have been linked to an increased risk of heart disease and stroke when used long term. These known risks, supported by the FDA's warning in 2005, has prompted many clinicians to prescribe acetaminophen instead. But do acetaminophen products confer a lower risk of cardiovascular effects? Join us for this episode to review the results from recent trials assessing similar blood pressure effects from regular use of acetaminophen.  Episode resource links: https://doi.org/10.1161/CIRCULATIONAHA.121.056015 Circulation. 2022;145:416–423 https://doi.org/10.1093/eurheartj/ehac059; European Heart Journal.  2,24,2022 Guest: Robert A. Baldor MD, FAAFP   Music Credit: Richard Onorato