Podcasts about CTD

A 52-year-old man presents for an initial primary care visit at the nurse practitioners practice period he has not seen any health care providers since age 38, stating that he has been in good health. Social history, drinking approximately 2 beers per night over the weekend, two nights per week, has a 5 pack year cigarette smoking history, having taken up smoking when he was in college, and quit at age 22. He reports feeling well and without chief complaint or chronic health problems.  He asks about what kind of cancer screening he should have. The NP advisors which of the following?A. Colonoscopy B. Prostate specific antigen (PSA) C. Low dose chest CTD. Given his history, no routine cancer screening is advised. ---YouTube: https://www.youtube.com/watch?v=qnKPe2EHgl4&list=PLf0PFEPBXfq592b5zCthlxSNIEM-H-EtD&index=115Visit fhea.com to learn more!

In this episode, Jeffrey Allen, a passionate advocate for rare disease awareness and a dedicated father to Lucas, who has creatine transporter deficiency. (CTD is also referred to as SLC6A8 Deficiency, CRTR, and X-linked Creatine Transporter Deficiency.Mutations in the SLC6A8 gene result in CTD.While patients with CTD have the necessary AGAT and GAMT enzymes to form creatine, the creatine transporter does not function properly. This results in creatine in the bloodstream, but not in the brain and muscles.) Jeffrey shares his journey of parenting a child with a rare disease, the life lessons he has learned from Lucas, and his experiences participating in the Ruck for Rare and the Beast Games. He emphasizes the importance of community support, advocacy, and the beauty found in challenges. The conversation highlights the significance of genetic testing and awareness for rare diseases, as well as the need for connection and communication among parents in similar situations.

The ASX 200 kicked another 93 points higher to 8238 (1.1%) as China appears to often its tactics. A big kick in US futures on the news helped. Banks led the way higher for a change. The Big Bank Basket up to $269.96 (+1.6%) ahead of the results kicking off next week. CBA up 1.4% and WBC playing some catch-up up rising 1.9%. MQG finally joined in, and other financials did ok with the exception of XYZ, which cratered 26.7% on a downgrade and disappointing earnings. REITs continued higher led by GMG up 1.4% and SCG up 0.6%. Industrials continued to find strength, WOW up 2.3% and COL up 2.1% with WES up 1.2%. Retail took a breather, but tech was mixed with WTC looking at a potential US acquisition up 0.7%. The All-Tech Index down 0.9% as CPU weighs. Off 4.1%. Travel stocks sold down after CTD issued a warning, off 10.0% dragging WEB down 4.2%. Resources initially languished buy bucked up as China news came through, BHP up 0.7% and FMG rallying 1.1%. Gold miners also picked up with news that GOR had gone into a halt pending a takeover offer potentially, NST finding a base up 0.7% and EVN up 2.9% on copper rallies too. MIN rallied 0.8% with LYC under a little pressure still on Ukraine moves and China holding a olive branch. Oil and gas better, WDS up 2.0% ahead of OPEC+ meeting Monday, uranium stocks continue to push ahead as shorts cover, PDN up 2.8% and BOE up 5.3%. In corporate news, CSC jumped 2.8% on record revenues. On the economic front, retail trade rose 0.3% MoM. Asian markets rose, Japan up 1.2%, HK up 1.6% and China closed for a holiday. 10-year yields steady at 4.22%Want to invest with Marcus Today? The Managed Strategy Portfolio is designed for investors seeking exposure to our strategy while we do the hard work for you. If you're looking for personal financial advice, our friends at Clime Investment Management can help. Their team of licensed advisers operates across most states, offering tailored financial planning services.  Why not sign up for a free trial? Gain access to expert insights, research, and analysis to become a better investor.

The ASX 200 closed up 74 to 8071 in another strong day pushing to a two-month high. Up 0.9%. All sectors firing, the banks did well with NAB up % and WBC up % as the Big Bank Basket crept to $261.14 (0.4%). Financials also in demand, PNI up 2.3% PPT up 3.1% and MQG up 0.8%. AMP continues to push higher, up another 3.6%. Insurers and REITS firmed, GMG up 1.6% and SCG rising 0.9% with SUN better by 0.7%. Industrials better across the board, BXB bounced back 1.5% with CPU up 1.9% and ORG rising 3.2%. Retail stocks also in demand again, JBH up % and TPW rising %. Travel stocks also better, CTD up 4.3% leading the pack. Healthcare pushed back up too, PME up 2.7% and TLX recovering a little. In resources, iron ore miners gained with FMG quarterly and a broker upgrade helping it rise 5.8% with S32 up 2.6%. The gold sector recovered some of its recent losses with GMD up 5.1% and BGL rising 4.0%. NST quarterly disappointed on production guidance and fell 4.7%. Heavily shorted resource company also squeezed a lot higher, MIN up 13.2% after its quarterly, uranium stocks continue to power ahead, PDN up 8.5% with BOE up 14.3%. Lithium plays also in demand, LTR up 5.6%.  WDS rallied 1.5% on its big US LNG project FID. In corporate news, EDV got a new CEO, WHC rose on quarterly production report, AIA fell as it announced it would delay a second runway. Nothing on the economic front. Asian market better, Japan up 0.4%, China down 0.1% and HK up 0.1%. 10-year yields 4.19%.Want to invest with Marcus Today? The Managed Strategy Portfolio is designed for investors seeking exposure to our strategy while we do the hard work for you.If you're looking for personal financial advice, our friends at Clime Investment Management can help. Their team of licensed advisers operates across most states, offering tailored financial planning services.  Why not sign up for a free trial? Gain access to expert insights, research, and analysis to become a better investor.

CTD has a new album coming out very soon, and we are going to do our best to help him get it on vinyl !!!

The ASX 200 shook off early losses as banks pushed ahead. The index closed down 2 points at 7800 (0.03%), with CBA hitting a record high! Up 4.2% The strength here has masked underlying index weakness.  Other banks trailed in its wake with the Big Bank Basket up to $260.87 (+2.5%). Other financials were mixed, GQG up 2.9% with CGF also doing well, IFL dropped 4.3% on a broker downgrade, PNI fell 2.4% and XYZ off 5.5%. REITs also fell hard, GMG down 1.6% and CHC falling 1.2%. Industrials also fell with tech under serious pressure, WTC down 2.4% and the Index down 2.0%. Retail fell too, LOV off 1.6% and APE down 1.6%. Travel stocks fell, FLT off 4.1% and CTD falling 2.9%. In resources, gold miners were the stars again, NST up 3.0% and EVN pushing 4.9% ahead as copper hit a two-week high. GMD up 1.4% and OBM rose 3.0%. Lithium miners fell as CATL is pushing ahead with sodium-ion technology. Uranium stocks trounced as DYL paused its Namibian operations, falling 8.2% and PDN down 12.5%. Iron ore miners steady, despite the fall in iron ore in Singapore. In corporate news, MQG rose 0.6% as it sold is asset management business to Nomura. BGL fell 7.1% after more detail on its hedge book emerged. ILU and REE joined forces to bid for a Kenyan Rare earth project. Nothing on the economic front. Asian markets were better than expected with 10-year yields at 4.23%.Want to invest with Marcus Today? The Managed Strategy Portfolio is designed for investors seeking exposure to our strategy while we do the hard work for you.If you're looking for personal financial advice, our friends at Clime Investment Management can help. Their team of licensed advisers operates across most states, offering tailored financial planning services.  Why not sign up for a free trial? Gain access to expert insights, research, and analysis to become a better investor.

The ASX 200 fell 32 points to 7828 (0.4%) after a failed rally attempt petered out. Losses across the board with the banks under pressure again, the Big Bank Basket slipping to $234.26(-0.7%). MQG down again off 0.9% with other financials sliding lower, PNI down 5.4% and MFG off 1.8%. REITs down led by GMG off 1.6% and SCG down 1.5%. Industrials also under pressure, ALL off 1.6%, QAN falling 2.7% with tech stocks falling, WTC down 2.3% on the governance update. Utilities also gave up some recent gains, ORG down 1.9% and AGL off 2.0%. Retail was mixed, LOV down 3.3% but JBH found friends on a broker note, up 3.6%. Travel stocks dropped, WEB down 2.9% and CTD off 2.8%.Resources fared slightly better in places, BHP unchanged, RIO off 0.7% and FMG falling 1.0%. Gold miners were mixed despite a push above $3000, EVN off 0.9% and GOR off 4.0%, falling again. SPR fell 1.4% and GMD off 1.1%. NEM up 1.0%. Lithium stocks bid higher but lost momentum, LTR up 2.1% and MIN smashed 3.9% on another accident on its haul road. Well off its lows. Uranium stocks doing well today as shorts continue to cover, DYL up 4.5% and BOE up 3.3%. In corporate news, MYR dropped 1.3% on flat sales. DDR dropped down 1.4% as David Dicker sold down his holding, CMM off 4.2% as it unwound its hedge book.Nothing locally on the economic front, the BoJ kept rates unchanged. Fed to come. Asian markets firm but uninspiring, Japan up 0.6%, China down 0.1%, HK up 0.2%. 10-year yields steady at 4.41%.Want to invest with Marcus Today? The Managed Strategy Portfolio is designed for investors seeking exposure to our strategy while we do the hard work for you. If you're looking for personal financial advice, our friends at Clime Investment Management can help. Their team of licensed advisers operates across most states, offering tailored financial planning services.  Why not sign up for a free trial? Gain access to expert insights, research, and analysis to become a better investor.

The ASX dropped hard and bounced a little closing down 72 points at 7890 (0.9%) after touching 7818. Banks were the turnaround story with the Big Bank Basket down to $240.73 (0.2%). MQG suffered as US investment banks have sunk. Other financials were also sold down hard, GQG off 3.2% and XYZ falling 6.3% with insurers slipping lower as government warns on Alfred issues. REITs fell back to earth, DGT dropped 7.4% on a broker downgrade, as HMC fell 9.7% too, SCG off 0.9%. Industrials slipped across the board, QAN fell 8.9% with it ex-dividend too, SGH down 3.2% and CPU falling 3.6%. Retail under pressure, JBH down 2.5% and TPW sliding 3.7%. Travel stocks took their cue from Delta Airlines, CTD off 0.5% and FLT falling 3.6%. Tech was also on the nose for obvious reasons, WTC down only 1.9% after bouncing hard off the lows, XRO saw no real bounce with the All-Tech Index down 4.0%. Resources was an interesting space. BHP and RIO both rallied hard, gold miners fell hard despite bullion prices picking back up. NST fell 1.9% and NEM dropped 2.6%. Lithium stocks under pressure as usual, oil and gas stocks better, WDS up 1.2% and uranium remains under a toxic cloud. In corporate news, NIC saw a large block trade causing a drop of 19.9% combined with possible tax changes. ASB in a trading halt as it seeks $200m at 380c together with a founder partial sell down. PNV lost its CEO and more value, GYG fell 2.2% on details of recently released escrow stock. In economic news, consumer confidence rose in March. In Asia, Japan down 1.3%, HK off 0.8% and CSI China off 0.6%. 10-year yields 4.36%. Want to invest with Marcus Today? The Managed Strategy Portfolio is designed for investors seeking exposure to our strategy while we do the hard work for you.If you're looking for personal financial advice, our friends at Clime Investment Management can help. Their team of licensed advisers operates across most states, offering tailored financial planning services.  Why not sign up for a free trial? Gain access to expert insights, research, and analysis to become a better investor.

The other gamelines in the World of Darkness rarely engaged with Changeling very deeply, but now and then, a book would have a chunk of pages illuminating some new corner of the lore. We're looking to Vampire this week, and in particular the first Dark Ages corebook and the original Dark Ages Companion. This first edition of Dark Ages, using the second edition Vampire ruleset, was contemporaneous with early Changeling—and it shows. These two books show glimpses into fae conceptions that didn't quite make it into the deep history, let alone Dark Ages: Fae when that finally dropped, but we're curious about how they might still be of use. And beyond that, the rich setting information in this line is useful for anyone looking to set up a medieval Europe game that is more CtD than DA:F. We promise this is not a deep readthrough of 500 Vampire pages! That being said, as promised, the Fishmalk: Even mad vampires can use a friend once in a while! The two books in question are available for purchase at https://www.storytellersvault.com/product/2672?affiliate_id=3063731 and https://www.storytellersvault.com/product/100?affiliate_id=3063731, respectively. We are available but not for purchase at: Discord: https://discord.me/ctp Email: podcast@changelingthepodcast.com Facebook: https://www.facebook.com/profile.php?id=100082973960699 Mastodon: https://dice.camp/@ChangelingPod Patreon: https://www.patreon.com/changelingthepodcast YouTube: https://www.youtube.com/@ChangelingThePodcast your hosts Josh Hillerup (any pronoun) rolls Chimerical Alchemy to distill dreamstuff into heraldic tinctures impossible for human eyes to discern. Pooka G (any pronoun/they) has successfully used the Ride Skill only once and on a camel. Uns ist in alten maeren  | wunders vil geseit von heleden lobebaeren  |  von grozer arebeit von vroevden hohgeciten  |  von weinen und von klagen von chvener recken striten  |  muget ir nu wunder hoeren sagen. (We have been told in ancient tales many marvels / of famous heroes, of mighty toil, / joys and high festivities, of weeping and wailing, / and the fighting of bold warriors – of such things you can now hear wonders unending!) —The Nibelungenlied, tr. A.T. Hatto

 The ASX 200 finished down around 11 points at 8241(0.1%) with CPI coming in as expected. Once again results were the focus, banks found buyers with the Big Bank Basket up to $253.05 (+1.1%) with CBA leading the way up 1.3%. MQG rose 0.6% and insurers flat. REITs were weaker, GMG falling 1.6% and SCG off 3.3% on results. Industrials mixed again, WTC rose 2.1% as White became Chair and results showed no further surprises, the All-Tech Index still fell 1.3% with TLS under pressure off 1.9% and QAN down 2.3%. Retail stocks mixed, JBH off 0.6% with LOV finding friends in all the right places up 5.7%. Travel stocks arrived jet lagged as FLT touched down 10.2% and CTD fell 3.6%. DMP hit another 3.7% with LNW better by 7.8% on results. Resources were back in the doghouse as iron ore fell, FMG dropped 6.2% as it went ex-div, BHP off 1.5% and RIO down 3.4%. Gold miners ran out of luck, NST down 2.8% and EVN off 1.7%. NEM off just 2.0%. LYC fell 1.7% after results showed the effects of low REE prices. Uranium stocks showed more fall out with PDN results bringing no joy and coal down too. WDS gained 3.4% after broker comments. STO going nowhere. In corporate news, WOW fell 3.0% after cutting its dividend, PBH had an abundance of bid interest around the 106c level, up 32.5%. BAP rose 13.4% and WOR up 10.3% on results whereas APX crashed 33.3% on disappointment. PTM also suffering as results were nasty, off 20.0%. KLS was another casualty today, maybe just a flesh would, but down 15.2%. In economic news, the CPI came in as expected and hardly moved the dial. Asian markets mixed, Japan down 0.8% and HK up 2.8% with China up 0.6%.  10-year yields at 4.37%. Want to invest with Marcus Today? The Managed Strategy Portfolio is designed for investors seeking exposure to our strategy while we do the hard work for you. If you're looking for personal financial advice, our friends at Clime Investment Management can help. Their team of licensed advisers operates across most states, offering tailored financial planning services.  Why not sign up for a free trial? Gain access to expert insights, research, and analysis to become a better investor.

VOV1 - Các ngân hàng liên tục tung gói ưu đãi lãi suất vay mua nhà ngay từ đầu năm nhưng giá nhà quá cao đang là rào cản- Các giải pháp ưu đãi lãi suất và tăng nguồn cung nhà ở. - Liên danh CTD, FCN, CC1 trúng thầu 3.100 tỷ đồng sân bay Long Thành- Thị trường chứng khoán tăng điểm tích cực phiên cuối tuần trước

Another nasty day as the ASX 200 fell 96 points to 8323 (1.2%) as results and bank falls dominated. WBC fell another % and ANZ joined in too falling 3.1% with the Big Bank Basket down to $251.27 (-2.4%). MQG dropped 1.0% with financial sunder a little pressure. REITs fell as GMG returned to trade down 5.0% after the $4bn capital raise. Industrials were mixed, ALL dropped 4.3% despite a new buy back, WES rose 1.3% on good results, TLS also did well, up 5.6% after announcing a buy back. Retail stocks suffered, JBH down 4.2% and BRG falling 3.0%. CTD continued the positive vibes from the results up 4.7%. UNI did very well on results up 9.7%. In healthcare, PME dropped 3.7% and CSL down 2.3%. Resources suffered as RIO cut its dividend, falling 1.5% and BHP fell 2.0% as FMG were savaged on results, down 6.2%. Lithium stock surprisingly rose after PLS results, up 6.0% and oil and gas stocks rose, WDS up 1.0% and STO rising 2.1%. Coal stocks gained 8.9% on WHC results. Uranium stocks were mildly lower. In corporate news, MAF rose 8.7% on good numbers, WTC in a trading halt on governance issues. MP1 had stellar gains on beating expectations. Casualties included, SUL, MFG, and MGH. On the economic front, jobs data came in as expected at 4.1% unemployment and record participation. Asian markets fell, Japan under pressure on proposed car tariffs. Down 1.5%, HK off 1.4% and China down 0.4%. 10-year yields steady at 4.53%. Want to invest with Marcus Today? The Managed Strategy Portfolio is designed for investors seeking exposure to our strategy while we do the hard work for you.If you're looking for personal financial advice, our friends at Clime Investment Management can help. Their team of licensed advisers operates across most states, offering tailored financial planning services.Why not sign up for a free trial? Gain access to expert insights, research, and analysis to become a better investor.

The ASX took another beating down 62 points to 8419 (-0.7%) as NAB cratered 8.1% and the Big Bank Basket came undone, down to $257.57 (-2.8%). MQG held up well considering, other financials came under some pressure, GQG off 3.2% and HMC down 3.9%. REITs were weighed down by the giant $4bn capital raise from GMG to fund its data centre push. DXS off 2.3%, and SGP fell 3.7% on results. Industrials were mainly weaker, WES off 1.8%, WOW and COL eased, retail fell, JBH down 2.3%, and SUL 2.9% cheaper. Travel stocks did well after CTD cheered the sector, up 10.3%. WEB up 4.4%, and FLT up 3.4%. LNW powered 9.6% ahead on an acquisition and ALL joined in the fun up 1.0%. Tech better, with CPU up 1.4% and WTC off 1.4% and the All-Tech Index gained 0.7%. Resources were patchy again, BHP flat and FMG down 0.6% on legal issues, gold miners rose, NEM up 0.5% and NST up 2.1%. Lithium stocks on the nose, MIN crashed 20.7% as it cancelled the dividend and announced a big loss. Energy stocks sold down again, WDS off 2.0% and STO falling 4.5% on results.  On the corporate front, NAB the biggest disappointment on margin compression and rising impairments. CBA was ex-dividend today, NGI rose 15.5% on results, and SXE jumped 14.2% after very positive results. VNT also out today marched 7% ahead. Nothing on the economic front. Asian markets eased, Japan down 0.3% and HK off 0.2%, with China up 0.6%. 10-year yields at 4.52%.Want to invest with Marcus Today? The Managed Strategy Portfolio is designed for investors seeking exposure to our strategy while we do the hard work for you.If you're looking for personal financial advice, our friends at Clime Investment Management can help. Their team of licensed advisers operates across most states, offering tailored financial planning services.Why not sign up for a free trial? Gain access to expert insights, research, and analysis to become a better investor.

 A quiet cautious session as the ASX 200 gave back 9 points to 8411. Down 21 points for the week after a torrid start. Banks were solid ahead of CBA results next week. The Big Bank Basket rose to $268.42 +0.2%) MQG slipped slightly with GQG down 1.3% with insurers steady. REITs better on lower 10-year yields, GMG up 0.6% and CHC up 0.5%. Industrials were mixed, and REA kicked 2.8% on broker upgrades. WES slid 1.1% with retail firm, PMV up 1.2% and SUL up 2.6%. Travel stocks also in demand, WEB up 2.6% and CTD rising 3.3%. DMP rose 21.3% like a cheesy crust as store closures were announced in Japan. Finally. Healthcare on the nose as RMD continues to stagger around after quarterly, down another 2.6%. CSL off 1.1% and PME falling 1.5%. Resources were generally weaker, though iron ore miners rose, BHP up 0.6% and FMG up 1.9%. Gold miners saw some profit taking, NST down 2.4% and WGX off 2.0%. Rare earths LYC up 6.1% on Chinese fears, and lithium stocks walloped as CATL rumoured to be reopening a lepidolite mine. PLS down 4.3% and LTR off 4.4%. Energy stocks fell, STO down 0.9% and WHC down 3.9% with uranium under pressure. In corporate news, MMS fell 10.4% on a broker downgrade, and NCK rose 10.5% on better-than-expected results. SIG guided up and rose 3.2%. Nothing locally on the economic front. Asian markets mixed, Japan down 0.6% and HK up 1.5% and China up 1.7%. 10-year yields slightly higher at 4.36%.Why not sign up for a free trial? Get access to expert market insights and manage your investments with confidence. Ready to invest in yourself? Join the Marcus Today community.

In this interview, Drs. Scali and Spratt discuss how the historical norms are being challenged for connective tissue disease patients (CTD) and endovascular repair.

Listen to the show and this will make sense. What kind of punishment did Sean subject us to? Well Dr. Suess is involved. Also Wicked is Porn, brothel strange requests and Xmas trees going away Plus FREE MONKEYS and Shotgun Stories Check out our social media pages: YouTube: https://www.youtube.com/@ctdpodcast FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off

Listen to the show and this will make sense. We can you hear about fake bears causing real damage, hamsters on a plane and can I do that drunk? Plus T-day foods ranked, Toy HOF and Shotgun Stories Check out our social media pages: YouTube: https://www.youtube.com/@ctdpodcast FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off

Listen to the show and this will make sense. What's the Best Xmas movie of all time? Who is the best pop star of this century? Can I get a job to break into your house for Xmas? Find out all answers on this episode. Plus details on a real treasure hunt and Shotgun Stories Check out our social media pages: YouTube: https://www.youtube.com/@ctdpodcast FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off

Listen to the show and this will make sense. We review the year in porn, name the worst Xmas songs, and talk about a hall pass for Christmas. Plus we Raise our Glasses and Shotgun Stories Check out our social media pages: YouTube: https://www.youtube.com/@ctdpodcast FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off

Listen to the show and this will make sense. It's the 1st show of the new year and we talked about the things that make you unlikable to others, the greatest actors of the 21st century and a new edition of the Fanny Pack Chronicles. Plus a round of Sunshine State and Shotgun Stories Check out our social media pages: YouTube: https://www.youtube.com/@ctdpodcast FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off

Welcome to this OncoAlert Session Round Up during ASH24, focusing on Multiple Myeloma pharmacologic therapies.GMMG-HD7 Trial (JCO Publication)This phase 3 trial evaluated adding isatuximab (Isa) to the standard RVd (lenalidomide, bortezomib, dexamethasone) regimen in transplant-eligible patients with newly diagnosed multiple myeloma. Part 1 randomized 662 patients to Isa-RVd or RVd, followed by autologous stem cell transplantation and a second randomization to lenalidomide or Isa-lenalidomide maintenance. Isa-RVd showed higher minimal residual disease (MRD) negativity rates post-transplant (66% vs 48%) and improved progression-free survival (PFS) with a hazard ratio of 0.70 (P = .0184). Isa-RVd plus lenalidomide maintenance further improved PFS (P = .016), underscoring Isa's role in prolonging MRD negativity and PFS.IMROZ Trial (Phase 3)This trial analyzed Isa-VRd (isatuximab, bortezomib, lenalidomide, dexamethasone) versus VRd in transplant-ineligible patients with newly diagnosed multiple myeloma. Isa-VRd led to significant improvements in PFS and deeper, sustained MRD negativity, with 68.6% achieving MRD negativity by month 36 compared to 50.8% in the VRd group. Isa-VRd also resulted in lower MRD loss rates during maintenance and improved conversion from MRD positivity to negativity, leading to longer PFS. These findings highlight Isa-VRd's potential for faster, durable responses and support its use to improve long-term outcomes in these patients.UK MRA Myeloma XI+ TrialThe phase 3 UKMRA/NCRI Myeloma XI+ trial compared KRdc (carfilzomib, lenalidomide, dexamethasone, cyclophosphamide) to sequential triplet therapies (CRd, CTd) in newly diagnosed multiple myeloma patients. After a median follow-up of 102 months, KRdc improved PFS (56 vs 37 months, hazard ratio 0.69, P < 0.001) across cytogenetic risk groups, with higher MRD negativity rates. Early MRD negativity correlated with better PFS. While overall survival was similar in contemporaneously randomized patients (76% vs 71% at 60 months), non-contemporaneous controls showed an overall survival benefit with KRdc (76% vs 68%, hazard ratio 0.80, P = 0.011). These results emphasize the depth of responses with KRdc, particularly for high-risk patients, and the importance of early MRD negativity for improved PFS and survival.DREAMM-7 Trial (Phase 3)This trial compared belantamab mafodotin (BVd) versus daratumumab (DVd), both combined with bortezomib and dexamethasone, in relapsed/refractory multiple myeloma. BVd demonstrated a significant PFS benefit (36.6 vs 13.4 months, hazard ratio 0.41, P < 0.00001), with higher complete response and MRD negativity rates (25% vs 10%). BVd also showed a longer response duration (35.6 vs 17.8 months) and early trends favoring overall survival (84% vs 73% at 18 months). Median overall survival was not reached, but projections estimate 84 months for BVd versus 51 months for DVd. BVd's safety profile included manageable ocular events, positioning it as a promising option for relapsed/refractory multiple myeloma after first relapse.AQUILA Trial (NEJM Publication)This phase 3 trial evaluated subcutaneous daratumumab as monotherapy versus active monitoring in high-risk smoldering multiple myeloma. Among 390 patients, daratumumab reduced the risk of progression or death by 51% compared to monitoring (hazard ratio 0.49, P < 0.001) after a median follow-up of 65.2 months. At five years, PFS was 63.1% in the daratumumab group versus 40.8% in the monitoring group. Overall survival was higher with daratumumab (93.0% vs 86.9%). Daratumumab was well-tolerated, with hypertension being the most common grade 3 or 4 adverse event (5.7%), and no new safety concerns emerged. Daratumumab significantly delayed progression to active multiple myeloma and improved survival in high-risk patients.Disclosure: Supported by Sanofi.

Our Carrier Connections program features a different X-linked condition each month with the goal to increase awareness of X-linked conditions and how they impact the lives of women and girls. This month, we are featuring creatine transported deficiency, or CTD. We are partnering with ⁠Association Xtraordinaire⁠ to bring you interviews and educational graphics on our social media pages. Our guests for this episode is Carole Chehowah, Vice President of Association Xtraordinaire. She is a mom of a 34-year-old daughter with CTD who diagnosed after 16 years after years of wondering. Carole is fighting for girls' recognition in X mutation syndromes. Carrier Connections is sponsored by Kyowa Kirin and Amgen. For more information about our organization, check out ⁠⁠⁠⁠⁠⁠⁠rememberthegirls.org⁠⁠⁠⁠⁠⁠⁠.

Our Carrier Connections program features a different X-linked condition each month with the goal to increase awareness of X-linked conditions and how they impact the lives of women and girls. This month, we are featuring creatine transported deficiency, or CTD. We are partnering with Association Xtraordinaire to bring you interviews and educational graphics on our social media pages. Our guests for this episode are Bonnie, an 18-year-old tennis player living with CTD and her mother, Andrea. Carrier Connections is sponsored by Kyowa Kirin and Amgen. For more information about our organization, check out ⁠⁠⁠⁠⁠⁠rememberthegirls.org⁠⁠⁠⁠⁠⁠.

This week on the Circling the Drain Podcast in addition to the usual nonsensical stuff, we interviewed Andrew Graziosa who worked on the horror film Terrifier 3. We get some backstage info and news about the Terrifier Universe. As for the nonsensical stuff, we talked about peanut butter and jelly M&M's, Male and female AI fighting and the Fanny Pack Chronicles continue. All that and a game of Law of the Land and Shotgun Stories. Listen to the show and it will all make sense. Check out our socials and like, review, subscribe: YouTube: https://www.youtube.com/@ctdpodcast FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off If you give us a chance, we'll give you a laugh

This week on the Circling the Drain Podcast we found out that cassettes may be worth something, how a vacuum can be racist and Thanksgiving pizza is back All that and a game of Hangman News and Shotgun Stories. Listen to the show and it will all make sense. Check out our socials and like, review, subscribe: YouTube: https://www.youtube.com/@ctdpodcast FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off If you give us a chance, we'll give you a laugh

If you give us a chance, we'll give you a laugh Why not to piss off a forklift operator, Can you name these 1 hit wonders and , Why isn't the balloon in the Toy Hall of Fame Those topics and 124 yr old chocolate, Canadian purple apples and Shotgun Stories Listen to the show and it will all make sense. Check out our social media pages: YouTube: https://www.youtube.com/@ctdpodcast FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off

If you give us a chance, we'll give you a laugh We learned you can get an award for breathing out your butt, you can hire someone to bust up your wedding and how someone got to live on a prayer. Also we celebrated Redheads, Bald heads and Cheeseburgers oh and Shotgun stories. Listen to the show and it will all make sense. Check out our social media pages: YouTube: https://www.youtube.com/@ctdpodcast FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off

If you give us a chance, we'll give you a laugh We re-cast Dancing with the Stars, we learned what we didn't know about Carolina's baby shower, we learned what BAM? is, Sean assigned us homework and get paid to taste pumpkin foods. Also a round of Sunshine State and of course Shotgun Stories. Listen to the show and it will all make sense. Check out our social media pages: YouTube: https://www.youtube.com/@ctdpodcast FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off

If you give us a chance, we'll give you a laugh From Celebs you can't hate to Krabby Patties to Sean's old age activities we covered alot. Also The World Gravy Wrestling Championship and Shotgun Stories Listen to the show and it will all make sense. Check out our social media pages: YouTube: https://www.youtube.com/@ctdpodcast FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off

We had a stories about snakes (real and human) and how much damage they can do. A mantra for riding a roller coaster when you're scared and pets having weird accidents. (BTW They're all ok) Oh and can you tell which story is fake in a round of 2 News and a Lie plus Shotgun Stories. Hey they make meth in pineapple flavor now! Listen to the show and it will all make sense. Check out our social media pages: YouTube: https://www.youtube.com/@ctdpodcast FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off If you give us a chance, we'll give you a laugh

We know what Snoop got paid at the Olympics, where the McRib may have originated, the perfect Relaxation Day and what's the most useless thing you can't forget. Plus can you guess my Mt Rushmore's and Shotgun Stories. Listen to the show and it will all make sense. heck out our social media pages: YouTube: https://www.youtube.com/@ctdpodcast FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off If you give us a chance, we'll give you a laugh

If you give us a chance, we'll give you a laugh Not sure why or how but we covered the following: The New ABC's, Fanny Pack Chronicles, A Pop Tart Party, AI robots are coming to help?, What you forget while traveling and Thrifting Disney style. Plus our bonus Shotgun Stories Listen to the show and it will all make sense. Check out our social media pages: YouTube: https://www.youtube.com/@ctdpodcast FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off

Our friend Larry from The Retro Gamers Podcast showed up to talk about his appearance at The Long Island Retro Gamers Expo - Go to LIRETRO.com for info. We also talked about What Men Want, problems on land, sea and air and movie reviews. Don't worry we didn't forget to play a round of Law of the Land and Shotgun Stories. Listen to the show and it will all make sense. Check out our social media pages: YouTube: https://www.youtube.com/@ctdpodcast FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off If you give us a chance, we'll give you a laugh

If you give us a chance, we'll give you a laugh Wait What?!? Hello Kitty isn't a cat?!? Do we or don't we want Olympians having sex? JoJo breaks a record, The Kelce's have a cereal and can money buy you happiness? Also a game of Hangman News and Shotgun Stories Listen to the show and it will all make sense. heck out our social media pages: YouTube: https://www.youtube.com/@ctdpodcast FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off

 In this episode of The Digital Executive Podcast, host Brian Thomas welcomes Projjal Ghatak, founder of OnLoop, to discuss his innovative approach to collaborative team development (CTD) and the future of work. Projjal shares his journey from leading roles at Uber and Accenture to creating OnLoop in response to the inefficiencies in traditional performance management systems.He delves into how OnLoop addresses the unique challenges of hybrid and remote teams by fostering intentionality and continuous feedback using advanced AI tools. The conversation explores the seismic shifts in the workplace driven by hybrid work, AI ubiquity, and immersive VR, highlighting OnLoop's role in enabling optimal productivity and team cohesion in this new era. Projjal's insights offer a compelling vision for leveraging technology to transform workforce management and drive significant improvements in team development and collaboration.

We were all over the place this week: she bought a replica sex doll, he had an x rated margarita and she's got the Oneyun. Plus we learned about mystery travel, paying people to attend a wedding, a round of Sunshine State and Shotgun Stories. Listen to the show and it will all make sense. Check out our social media pages: FB: https://www.facebook.com/groups/395003747727423 YouTube: https://www.youtube.com/@ctdpodcast IG: ttps://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off If you give us a chance, we'll give you a laugh

We learned that there's someone for everyone, even if that person for you, IS YOU. Sologamy Who's wand is worth the most from the Harry Potter series? Also we wondered why wives choose murder over divorce. This and weird food news and Shotgun Stories Listen to the show and it will all make sense. YouTube: https://www.youtube.com/@ctdpodcast Check out our social media pages: FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off If you give us a chance, we'll give you a laugh

This week on the Circling the Drain Podcast: We played our annual round of Sex Toy or Firework, but since it's Shark Week we added the rules to a themed drinking game. We found out the rise of AI started with a sexbot and well Bleed for Weed was a giant hit. Oh we didn't forget Shotgun Stories. YouTube: https://www.youtube.com/@ctdpodcast Listen to the show and it will all make sense. Check out our social media pages: FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off If you give us a chance, we'll give you a laugh

Can we get Sean on the Hollywood Walk of Fame? Does your GF let you do these 5 things? What lame world record can you break? Also a bday AITA, a round of Law of the Land and our Shotgun Stories. Listen to the show and it will all make sense. Check out our social media pages: FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast YouTube: https://www.youtube.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off If you give us a chance, we'll give you a laugh

Life lessons from this week's show: Go ahead and order from the kid's menu. Sure go to the foot fetish nail salon. Hey I know it's a lemon, but $400 sounds fair. Plus a judge rules on taco's and Shotgun Stories Listen to the show and it will all make sense. Check out our social media pages: FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast YouTube: https://www.youtube.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off If you give us a chance, we'll give you a laugh

Which celeb do you hate the most this year? I'm going to the library and check out a person. You heard right? The strangest OnlyFans accounts are out there. Plus a game of 2 News and a Lie and Shotgun Stories Listen to the show and it will all make sense. Check out our social media pages: FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast YouTube: https://www.youtube.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off If you give us a chance, we'll give you a laugh

Can you spell the most mis-spelled words? Can I go to summer camp for adults? Can I run a Blockbuster out of my house? Yes to all plus Disney adults live longer and Shotgun Stories. Listen to the show and it will all make sense. Check out our social media pages: FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast YouTube: https://www.youtube.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off If you give us a chance, we'll give you a laugh

It was a well rounded show: Well.. yuck...Sean punished us. bleeech, with Sour Patch Oreo's. Food news that's sad, cheesy and from the bottom of Grandma's purse Would you rather be better looking, smarter or richer (choose carefully) Plus we played the Summer Blockbuster Trilogy Game and Shotgun Stories Listen to the show and it will all make sense. Check out our social media pages: FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast YouTube: https://www.youtube.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off If you give us a chance, we'll give you a laugh

Find out if you have Rizz or are you Ohio. Gen Alpha speak Are you good enough to play on our Pop Culture Jeopardy team? Be a better person and do the things that don't require talent to do. Plus I'll be blunt for $ and Shotgun Stories Listen to the show and it will all make sense. Check out our social media pages: FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast YouTube: https://www.youtube.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off If you give us a chance, we'll give you a laugh

How to take care of your kid's school bully. How women can make $ doing something they already do Why can't Snoop Dogg ride in the HOV lane Plus overrated celebs and Shotgun Stories Listen to the show and it will all make sense. Check out our social media pages: FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast YouTube: https://www.youtube.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off If you give us a chance, we'll give you a laugh

Can you tell the difference between a Master Class and Master Bait? A job for you if you like wieners and balls and is it a raccoon or a rabbit? Plus Old and young crime and Shotgun Stories Listen to the show and it will all make sense. Check out our social media pages: FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast YouTube: https://www.youtube.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off If you give us a chance, we'll give you a laugh

Would you rather smell like Peeps or Pot? Old School Music makes a comeback (not what you would guess). Plus food news and Shotgun Stories Listen to the show and it will all make sense. Check out our social media pages: FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast YouTube: https://www.youtube.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off If you give us a chance, we'll give you a laugh

Sean and Ira decided to just talk while we wait for everybody. It was different, but is it good? You tell us. Welcome to The Sink Listen to the show and it will all make sense. Check out our social media pages: FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast YouTube: https://www.youtube.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off If you give us a chance, we'll give you a laugh

This week we handle balls while bowling, what could be a perfect marriage and where did all the bugles go. Plus pet peeves and Shotgun Stories Listen to the show and it will all make sense. Check out our social media pages: FB: https://www.facebook.com/groups/395003747727423 IG: https://www.instagram.com/circlingthedrainpodcast/?hl=en TikTok: https://www.tiktok.com/@ctdpodcast YouTube: https://www.youtube.com/@ctdpodcast Check out Cake Chick's site: https://www.instagram.com/cakechick1217/?hl=en At Cake Chick you get what you want. Use promo code CTD for 20% off If you give us a chance, we'll give you a laugh

We are joined tonight with CTD to gab about music and a whole lot more! Russia don't get to go to the Olympics nanny nanny boo boo!!!