Podcasts about ndea

In this fascinating episode, we dive deep into the race towards true AI intelligence, AGI benchmarks, test-time adaptation, and program synthesis with star AI researcher (and philosopher) Francois Chollet, creator of Keras and the ARC AGI benchmark, and Mike Knoop, co-founder of Zapier and now co-founder with Francois of both the ARC Prize and the research lab Ndea. With the launch of ARC Prize 2025 and ARC-AGI 2, they explain why existing LLMs fall short on true intelligence tests, how new models like O3 mark a step change in capabilities, and what it will really take to reach AGI.We cover everything from the technical evolution of ARC 1 to ARC 2, the shift toward test-time reasoning, and the role of program synthesis as a foundation for more general intelligence. The conversation also explores the philosophical underpinnings of intelligence, the structure of the ARC Prize, and the motivation behind launching Ndea — a ew AGI research lab that aims to build a "factory for rapid scientific advancement." Whether you're deep in the AI research trenches or just fascinated by where this is all headed, this episode offers clarity and inspiration.NdeaWebsite - https://ndea.comX/Twitter - https://x.com/ndeaARC PrizeWebsite - https://arcprize.orgX/Twitter - https://x.com/arcprizeFrançois CholletLinkedIn - https://www.linkedin.com/in/fcholletX/Twitter - https://x.com/fcholletMike KnoopX/Twitter - https://x.com/mikeknoopFIRSTMARKWebsite - https://firstmark.comX/Twitter - https://twitter.com/FirstMarkCapMatt Turck (Managing Director)LinkedIn - https://www.linkedin.com/in/turck/X/Twitter - https://twitter.com/mattturck(00:00) Intro (01:05) Introduction to ARC Prize 2025 and ARC-AGI 2 (02:07) What is ARC and how it differs from other AI benchmarks (02:54) Why current models struggle with fluid intelligence (03:52) Shift from static LLMs to test-time adaptation (04:19) What ARC measures vs. traditional benchmarks (07:52) Limitations of brute-force scaling in LLMs (13:31) Defining intelligence: adaptation and efficiency (16:19) How O3 achieved a massive leap in ARC performance (20:35) Speculation on O3's architecture and test-time search (22:48) Program synthesis: what it is and why it matters (28:28) Combining LLMs with search and synthesis techniques (34:57) The ARC Prize structure: efficiency track, private vs. public (42:03) Open source as a requirement for progress (44:59) What's new in ARC-AGI 2 and human benchmark testing (48:14) Capabilities ARC-AGI 2 is designed to test (49:21) When will ARC-AGI 2 be saturated? AGI timelines (52:25) Founding of NDEA and why now (54:19) Vision beyond AGI: a factory for scientific advancement (56:40) What NDEA is building and why it's different from LLM labs (58:32) Hiring and remote-first culture at NDEA (59:52) Closing thoughts and the future of AI research

In this episode of Gradient Dissent, host Lukas Biewald sits down with Mike Knoop, Co-founder and CEO of Ndea, a cutting-edge AI research lab. Mike shares his journey from building Zapier into a major automation platform to diving into the frontiers of AI research. They discuss DeepSeek's R1, OpenAI's O-series models, and the ARC Prize, a competition aimed at advancing AI's reasoning capabilities. Mike explains how program synthesis and deep learning must merge to create true AGI, and why he believes AI reliability is the biggest hurdle for automation adoption.This conversation covers AGI timelines, research breakthroughs, and the future of intelligent systems, making it essential listening for AI enthusiasts, researchers, and entrepreneurs.Mentioned Show Notes:https://ndea.comhttps://arcprize.org/blog/r1-zero-r1-results-analysishttps://arcprize.org/blog/oai-o3-pub-breakthrough

Send me a DM! ILY All!I know you will all be just as excited as I am to have back on the show one of our most requested and beloved guests: Top tier MONARCH operator and whistleblower, Founder of ‘Organize Safety', podcast host of ‘The Grey Area', anti-child abuse and survivor advocate, former GATE kid, all around badass warrior, and the absolute love of my life: Grey!A little bit about Grey if you're new here or missed his first episode where he shared his harrowing and inspiring testimony: Grey was born in New York into a multi-generational occult bloodline family and from a very young age, was groomed and programmed by his family, family acquaintances, and eventually the government and military to become a top tier skilled assassin and operator through MONARCH and other mind control experimentation projects funded by the CIA. After a traumatic event occurred when he was 8, his family relocated from New York to Tennessee where his abuse continued unbeknownst to him, and It wouldn't be until Grey was 25 that the two paths of the double life he was living would violently and suddenly collide, revealing every repressed memory from a tortured, painful, and horrific past. As his programming shattered, so did his life. Grey found himself facing time in prison after staged imprisonment charges were dropped on him, and at the same time, his family and loved ones were attacked and tortured as collateral damage to his awakening and first attempt at blowing the whistle on what his memories revealed. After working behind te scenes for over a decade, Grey decided to once again go public a year ago and has touched the hearts and minds of thousands through his whistleblowing journey and through the roll-out of Organize Safety, which is a revolutionary way to corroborate and cross-reference anonymous or public tips regarding perpetrators, abuse locations, and events. Today, Grey is back for Part 2 of an episode series we started a couple months ago on gifted and talented programs and their relationships to the CIA, NDEA and MK ULTRA. Unbeknownst to most, MK ULTRA was right in our face within our school systems as GATE, TAG and other gifted and talented programs were rolled out and marketed to parents as a prestigious educational opportunity for their children who were recognized as having attributes such as a high IQ and heightened spiritual gifts - and what we found out on Pt 1 is that these programs that appear benign are actually a sinister way for the CIA to scout for gifted children to place in MK ULTRA and related experimental programs while portraying them as benevolent. A commonality of MK ULTRA and SRA survivors that we see on ‘The Imagination' is their placement in these gifted programs in their formative school years, and it's a consistency of many others who were enrolled in GATE and related programs to have very little or no memory recollection of what happened to them while in these classes. CLICK HER FOR 15% OFF YOUR RIFE TECHNOLOGIES ORDER: Rife Technology – Real Rife TechnologyCONNECT WITH GREY:YouTube:  The Grey Area - YouTubeTwitter: Grey (@GreyAreaMonarch) / X (twitter.com)Rumble: GreyAreaOperator (rumble.com)Reddit: GreyAreaOperator (u/GreyAreaOperator) - RedditSubstack: The Grey Area | SubstackCONNECT WITH 'THE IMAGINATION':All linkSupport the Show.

Send me a DM! ILY All!This is a fun (and impromptu!) episode I did to outline a thread I've been constructing on Twitter that went viral on GATE (Gifted and Talented Education), TAG (Talented and Gifted), and related programs and the different conspiracies surrounding these government programs. Inspired by my incredible partner,  @greyareaoperator - who did an absolutely mind-bending episode on GATE and it's relationships to the NDEA and MK ULTRA, I took to Twitter / X and started asking questions. And the result was both staggering and shocking. The thread got shared hundreds of thousands of times and thousands of comments poured in from all over the world about people who have experiences in GATE / TAG programs. And would you believe that the most common demoninator of GATE kids is... that they don't remember what happened to them in GATE? In order to get the full scope of what I discuss in this episode, please watch the presentation Grey brilliantly put together for us on this episode: S4E47 | “‘Grey' - Gifted and Talented Education (GATE) Programs, the NDEA & Connections to MK ULTRA” : https://www.youtube.com/watch?v=7E53uxsgEbwAnd a little teaser that GATE Pt 2 with Grey will be coming soon! For now, enjoy this fun and whimsical episode where we use our imaginations together and dive into the dark side of gifted and talented programs...VIRAL GATE POST ON TWITTER / X : https://twitter.com/TheEmmapreneur/status/1774217292529680484CONNECT WITH THE IMAGINATION:EMAIL: imagineabetterworld2020@gmail.com    My Substack: https://emmakatherine.substack.com/BUY ME A COFFEE: https://www.buymeacoffee.com/theimaginationAll links: https://direct.me/theimaginationpodcastWebsite: https://standbysurvivors.com/Support the Show.

On this date in 1908, the Grand Forks Herald's front page blared the following headline: “VALLEY CITY GETS NEXT MEETING OF THE EDUCATIONAL ASSOCIATION.”

I know you will all be just as excited as I am to have back on the show for a second time: Top tier MONARCH operator and whistleblower, military veteran, Founder of ‘Organize Safety', podcast host and content creator, anti-child abuse advocate, someone who has had a massive and positive impact on my own life and on this project, and the first male mind slave survivor (now of many!) to step up to be featured on my podcast, Grey!Grey was born into a multi-generational occult bloodline family and from a very young age, was groomed and programmed by his family, family acquaintances, and eventually the government and military to become a top tier skilled assassin and operator through MONARCH and other mind control experimentation projects funded by the CIA. After a traumatic event occurred when he was 8, his family relocated to Tennessee where his abuse continued unbeknownst to him and It wouldn't be until Grey was 25 that the two paths of the double life he was living would violently and suddenly collide, revealing every repressed memory from a tortured, painful, and horrific past. As his programming shattered, so did his life. Grey found himself facing time in prison after staged imprisonment charges were dropped on him, and at the same time, his family and loved ones were attacked and tortured as collateral damage to his awakening and first attempt at blowing the whistle on what his memories revealed. And now, ten years later, Grey is back and speaking out for the second time. You don't have to watch Grey's first episode on ‘The Imagination' before listening to this episode, but I highly recommend listening to his incredible testimony he did on his first appearance on this podcast, and also would recommend an even deeper dive he has curated for all of us on his new podcast, ‘The Grey Area' that you can find on YouTube and Rumble along with other platforms that I'll link in the shownotes. This time around, Grey is going to take us down a rabbit hole of epic proportions on a subject that has been a hot button topic and a consistency in many survivor stories: The Gifted and Talented Education program - also known as the GATE program, and its affiliations with the government, MK ULTRA, and other sub-programs. A participant in the GATE program himself, Grey, has done extensive research on this topic and was the first person who came to mind to present on these mind control recruitment sub-programs when this topic first started being requested to present on this podcast.  Before I finish introducing this week's guest, I wanted to give a reminder that if you are a survivor or whistleblower who wants to share your story on the podcast or wants to share any information privately with me, you can now email me at IMAGINEABETTERWORLD2020@GMAIL.COM! Please send me a briefing of who you are and how I can support you whether it's through podcasting or sharing information. I also recently started a Substack that I'd love to have your support on that you can find at Emma's Substack | Emma Katherine | Substack CONNECT WITH GREY: YouTube:  The Grey Area - YouTubeTwitter: Grey (@GreyAreaMonarch) / X (twitter.com)Rumble: GreyAreaOperator (rumble.com)Reddit: GreyAreaOperator (u/GreyAreaOperator) - RedditSubstack: The Grey Area | SubstackCONNECT WITH 'THE IMAGINATION': All links: Emma Katherine on Direct.meSupport the show

Bon vendredi (ou bon lundi, si je suis honnête, léger retard dans la publication, on s'en excuse)! Cette semaine, on a reçu Mélissa St-Louis, de Kändea, pour jaser douance et TDA/H dans le monde du travail. Mélissa a eu la gentillesse de démystifier tout ça pour nous et de nous expliquer comment, concrètement, ça amène des défis pour les employés. Elle nous a aussi exposé sa vision, selon laquelle les personnes neurodivergentes sont un réel bassin de talent, et qu'il n'en tient qu'aux entreprises d'adapter légèrement leur marque employeur et leurs pratiques de gestion pour bénéficier de leur talent. Un épisode pertinent, positif, jovial... comme Melissa :)   Pour suivre Mélissa sur LinkedIn. https://www.linkedin.com/in/melissastlouis/ Pour en savoir plus sur son entreprise : https://kandea.ca/ Pour écouter Les Neurodivertissantes : https://lesneurodivertissantes.com/ -----   Pour nous laisser cinq étoiles et un commentaire sur iTunes: http://apple.co/3aWCq1D   Pour suivre La Talenterie : Site web: https://www.latalenterie.com/ Boîte à idées: https://www.latalenterie.com/idees Chaîne YouTube : https://www.youtube.com/channel/UCeuRuB8iUdRBB4Ri0pFIERA?view_as=subscriber LinkedIn : https://www.linkedin.com/company/42738397/admin/ Instagram : https://www.instagram.com/la_talenterie/   Et mon profil personnel sur LinkedIn : https://www.linkedin.com/in/sarah-jodoin-houle-cebs-crha-735b2049/   Un GRAND Merci à Charles «Chuck» Thompson-Leduc à la production, à la réalisation et au montage:)   Pour suivre Chuck : LinkedIn : https://www.linkedin.com/in/berlingot/ Instagram : https://www.instagram.com/chuckischuck/ Facebook : https://www.facebook.com/charles.tleduc

Shange was born Paulette L. Williams on October 18, 1948 in Trenton, New Jersey to an Air Force surgeon and an educator/psychiatric social worker. She graduated cum laude with her BS degree in American studies from Barnard College in New York City. In 1973 she changed her name after a failed marriage and suicide attempts. Her new name is from the Xhosa language, Ntozake, meaning “she who comes with her own things,” and Shange, meaning “she who walks among lions.” She then graduated from the University of Southern California in 1973. After joining a dance company she created the Choreo poem: “For colored girls who have considered suicide/when the rainbow is enuf.” The work was first produced off-Broadway and then premiered on Broadway at the booth theater in 1976. The play went onto win the OB award, the outer critics Circle award, and the a UTELCO award. Originally conceived as a Choreo poem, it has been published in book form, and adapted into a stage play. In 2010, Tyler perry wrote, produced, and directed the film adaptation, for colored girls, starring Whoopi Goldberg, Phylicia Rashad, Janet Jackson, and Loretta Devine. In 1978, she released nappy edges, a collection of 50 palm celebrating the voices of independent woman. In 1979 she produced the trilogy three pieces of poems, which won the LA Times book prize. In 1982 she released her first novel, sassafras, Cypress, and indigo, which he followed with Betsy Brown in 1985 and little Lane: resurrection of the daughter in 1994. Her work appeared in the black scholar, yard bird, miss magazine, essence magazine, the Chicago tribune, vibe, and third – world women. In addition to poetry, novels, essays and screenplays, she published four books for children. She also served on the faculty of the department of drama at the University of Houston. And Emmy, Tony, and Grammy award nominee, she received an NDEA fellowship in 1974, two Obie awards, Guggenheim fellowship in 1981, the Paul Robeson achievement award in 1992, the Living legend award from the national Black theater festival in 1993. She was inducted into the St. Louis Walk of fame. She passed away on October 27, 2018 at the age of 70. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/katherine-hutchinson-hayes/support

Have you heard the term non-destructive excavations? Well me neither before this interview but Kim's business NDEA is a leading supplier of this service to Tier 1 construction companies all over NSW. What's super impressive about Kim is that she's built up a sizeable business filled with lots of plant and equipment single handedly.Kim is the Sydney EO president for FY22 and clearly she loves getting involved with bsuiness and the community as she's also Vice-President of her industry body, the Civil Contractors Federation.More Infowww.ndea.com.au 

Hello, Again & again with another convo. This one is chicken soup served straight to you by the lovely & wonderful N'Dea Davenport. She gives so many jewels and gems in this ep its almost unbelievable. We go over what her experience with the past year has been like and all the work she has been taking the time to do. And not necessarily artistic work, but the work a person needs to do on themselves. There's also the appearance of a rare, semi-sentimental Late. Almost cut from the episode! There's been a LOT going on and we talk about the effect it has had on all of us and the opportunities than can still be found. Learn how to fish. THINGS JUST GET BETTER 2021

N’dea Jones joins the Tidal League Podcast to tell us her story, starting with WNBA Draft Night 2021 where she was chosen 23rd overall by the Seattle Storm and the big differences between being drafted in the WNBA and the NBA. We talk about the mental game and the things that keep her grounded, the power of prayer and her faith, the story of when she fell in love with the game - like real life, the ups and downs of that romance. An exceptional young woman - she’s finishing her second degree, a Masters of Jurisprudence - N’dea shares her thoughts on the path her life has taken, what’s it’s been like to play with the Storm and superstars Sue Bird, Breanna Stewart, and Jordin Canada, the scrimmages, the opportunity to play overseas, the players that have been her inspiration and what she hopes her legacy will be.

Ain't Nobody Rufus & Chaka Khan For Free To Blow The Whistle DJ Khaled ft Drake & Too Short Tap In Saweetie Complete DJ Teddy O and Jay Moore Slide OZI Bang Boogie Ill Blu feat Mostack Go DJ Strizzo feat Zone and Javon Black Scandalous Mis-Teeq feat Twista What About Your Friends TLC For The Love Of Money The O'Jays Money In The Grave Drake f. Rick Ross Loved By You Justin Bieber Ft. Burna Boy Forever Gyakie Ft. Omah Lay The Humpty Dance digital Underground Same Song Digital Underground ft 2Pac Doowutchyalike Digital Underground I Get Around Tupac Digital Underground Trust Me Guru ft N'Dea Davenport Stay Eternal Stay Down Lil Durk f. 6LACK & Young Thug Kiss It Better x Sunshine Rihanna vs Fat Joe Never Too Much Sunshine Luther Vandross, Fat Joe, Amorphous Pour It Up Rihanna Gettin Jiggy With It Will Smith The Greatest Dancer Sister Sledge vs Will Smith My Forbidden Lover Chic I Want Your Love Chic Smooth Operator Sade Caribbean Queen Billy Ocean I Hear Music In The Streets Unlimited Touch New Rules Dua Lipa What's Your Name Dillon Francis & Calvin Harris I Can't Wait Nu Shooz Real McCoy - Come And Get Your Love R No Plans for Love D-Nice ft Snoop Dogg, Ne-Yo, & Kent Jones Don't Fight The Feeling One Way

Hola a toda la comunidad educativa de la NEA, esperamos que estén muy bien. Estoy muy contenta de presentar la tercer emisión de este hermoso proyecto institucional de radio en la escuela. Para este encuentro la tematica es nuestra ciudad y su 138 aniversario, la utopía de la ciudad ideal imaginada por Julio Verne resiste al paso del tiempo. La Plata, heredera de ese diseño, tiene el formato exacto de France-Ville, descripta en la novela de Verne "Los quinientos millones de la Begún" (1879) En NEA abordando esta temática con una fuerte impronta institucional, que me enorgullece como secretaria académica del nivel secundario. Nos acompaña en esta tercera emisión la secretaria del nivel inicial Mariela Camou, con quien vamos a conversar sobre varios aspectos. Hola Mariela, qué lindo poder llegar a nuestra comunidad desde radio NdEA. Felicitaciones a las secretarias académicas por esta hermosa emisión , agradecer a los alumnos de inicial por los spot, especialmente a Nico y la participación en la narración de la Princesa Gokul a cargo de una alumna egresada de nuestra escuela en el 2013.- Excelente trabajo ;)

Note: This Broadcast is licensed via Live 365 and covers listeners in the USA (through SoundExchange, ASCAP, BMI, and SESAC) In Canada through (SOCAN and Re-Sound) and the UK through ( PPL and PRS for Music) The special guest on today's show is a chart busting artist, singer, songwriter, dancer, and DJ probably best known for her beautiful vocal stylings as the lead singer of the Brand New Heavies. Acid Jazz, Neo Soul, House Music, R&B, there is no box to put her talents in. She is amazing! She is N'Dea Davenport and she's having Brunch in the Basement with JaVonne & Terez

Edición especial que dedicamos a la vocalista N'Dea Davenport, repasando su disco como solista y sus colaboraciones junto a artistas como Dave Sereny, Michael Paulo, The Headhunters, Mondo Grosso, Louie Vega y José Padilla. Evidentemente también suenan varios temas de sus participaciones en discos de la banda británica The Brand New Heavies.

Agradece a este podcast tantas horas de entretenimiento y disfruta de episodios exclusivos como éste. ¡Apóyale en iVoox! Edición especial que dedicamos a la vocalista N'Dea Davenport, repasando su disco como solista y sus colaboraciones junto a artistas como Dave Sereny, Michael Paulo, The Headhunters, Mondo Grosso, Louie Vega y José Padilla. Evidentemente también suenan varios temas de sus participaciones en discos de la banda británica The Brand New Heavies.Escucha este episodio completo y accede a todo el contenido exclusivo de Cloud Jazz Smooth Jazz. Descubre antes que nadie los nuevos episodios, y participa en la comunidad exclusiva de oyentes en https://go.ivoox.com/sq/27170

This week on the show Chauncey and Dixon are discussing TI and his consistent fuckery, Disney Plus, Alexis Crawford and the importance of sex in relationships. We also want to thank our special guests Charles, Darin, and Ndea for blessing the mic this week! We want to shout out Juice who produced our new intro and outro music. Their social media will be linked below! If you'd like to ask FPBPodcast a question, send an email to: askfpb@gmaill.com Follow us on Twitter and Instagram at: Twitter: @fpbpodcast @chaunceybe_ @ddmcnasty Instagram: @fpbpodcast @chaunceybe @cousinwaynehead @chuckuniversity @_aimtoinspire @ndea.st Juice the Producer: Instagram: Juice_5210 https://soundcloud.com/search?q=juice%20323 Thanks for all of your support and make sure you rate comment and subscribe to the show!

RADIO TERAPIAS es una Emisora ​​Online perteneciente a la COMUNIDAD DE TERAPEUTAS HISPANOAMERICANOS UNIDOS y sirve como un espacio de Encuentro, Unión y Comunicación entre todos los Terapeutas del Continente y la Comunidad en general. En En RADIO TERAPIAS ponemos a disposición de la Comunidad Hispanoamericana este espacio para fomentar una mejor calidad de vida y la posibilidad de alcanzar un estado de conciencia con el Universo infinito. www.RadioTerapias.com/es

In this episode Ken and N'Dea sit down outside and talk about all the music we've missed including Chance's Big Day! We also talk about what it means to go pop followed by Euphoria and Lion King!! Stonedcation Podcast Season Episode 2-3. Curated by Ken & N'Dea Follow us at: @whokilledken @ndeajai

In this episode Ken and N'Dea sit down on Memorial Day with our good friends and guests Kendra and Maya to catch up about the week's news including why you shouldn't climb Mount Everest any time soon, Iggy Azalea's leaked photos, and our Netflix/ Hulu suggestions! We even answer some risky relationship questions!!! Tune in! Stonedcation Podcast Season Episode 2-2. Curated by Ken & N'Dea Follow us at: @whokilledken @ndeajai

SPOILER WARNING!!! In this episode Ken and N'Dea sit down with our guest and good friend Andy to talk about our impressions from Avengers: Endgame, an update on the NBA Finals, Our favorite music of right now and more! Stonedcation Podcast Season Episode 2-1. Curated by Ken & N'Dea Follow us at: @whokilledken @ndeajai

On the latest episode of "Women's Hoops Spotlight", Tom Turbiville chats with sophomore guard Kayla Wells and sophomore forward N'dea Jones.

Yes yes yes! Super special episode this week with the Grammy nominated, legendary, brilliant and powerful, N'Dea Davenport! N'dea has had a long and illustrious career in the music industry. We talk about a lot of stuff. From the underground creative community in Los Angeles to working with Guru to her success with the Brand New Heavies to her solo career and current creative endeavors here in Japan. N'dea has always found ways to express herself while staying true to her sense of artistic integrity. Balancing the past with the future. Being electric. Living in Japan and starting her newest creative outlet project, "Celectrixx." Theres really far too much to mention here so check out this episode to hear more about the ridiculous amazing life of N'dea Davenport. Her Wikipedia page is bullshittin! Weather Reports: Mega : Heather Victoria - Japan Guru & Ndea Davenport - Trust Me N'Dea Davenport - Whatever You Want (Jay Dee Remix) *************LINKS************ Megalateshow /on twitter, Facebook and Instagram faturl.com/megalateshow/?selected=0 paypal.me/megalateshow Weather Forecast calendar of upcoming dope culture shows going on in Tokyo! ↓↓↓↓↓↓↓↓ goo.gl/SmRW9u If you want your show in the Weather Forecast make sure to hit us at: mlsweatherforecast@gmail.com

This Talk Radio show aired Sunday, August 6, 2017Topic: A Conversation With N'Dea Davenport.It was an interesting and insightful conversation as N'Dea shared with us her start and love of music.We wish N'Dea Davenport continued success and thank her for extending her time to us. Thanks to everyone who listened in, who are still listening and continuous support of the show.Until next time, continue to...#ROCKon#RealChicksRock#RCR #RealDiscussions #StatusNetwork Check out the show replay here! https://youtu.be/zrvJeobdRGE Join us every 1st and 3rd Sunday, as we get together to discuss topics and issues that impact US. Listen or view us LIVE: 2 pm - 4 pm EST on www.StatusNetwork.net   Call in to the show (470) 251-4343 Join in on the conversation - We love to hear what's on your heart and mind!   Thank you for taking your time to listen to this podcast. For further details, please visit our Facebook page at https://www.facebook.com/RealChicksRock1   Stay Connected!   Subscribe to YouTube: https://www.youtube.com/c/realchicksrock Facebook - https://www.facebook.com/RealChicksRock1 Twitter - https://twitter.com/RealChicksRock1 Instagram - https://www.instagram.com/realchicksrock Pinterest - https://www.pinterest.com/rcr012/ Website: www.RealChicksRock.com Radio Station: www.StatusNetwork.net

N'Dea Flye discusses her first year basketball experience at University of New Mexico. In the this conversation, she expounds on: Communication between coach and athlete Advice for young female basketball athletes Pros & Cons of collegiate basketball life Her training/coach relation with Leland Johnson Why she decided to transfer Who's recruiting her now Future basketball aspirations "I want to first start off by saying, thank you UNM for a great freshman year...Thank you to my teammates for not just being there for me on the basketball court, but also off the court. You guys became my family. I also want to thank God for giving me the opportunity to play this sport and grow as a human being within this year, which has taught me a lot. With all that being said, I'd like to announce that I'll be transferring from UNM and re-opening my recruitment." Truly, Thank you New Mexico

Nick Archuleta is on leave from the faculty at Century High School in Bismarck where he taught Spanish I and II. He was elected as President of NDEA in June 2013, and is serving as the first-ever President of North Dakota United. Archuleta also served on the NDEA Board of Directors and is former Vice Chairman of the Education Standards and Practices Board having been appointed by former Governor John Hoeven as well as by Governor Jack Dalrymple.Resources:www.ndplaylist.orgwww.ndunited.org/thecuttingedTwitter:@thecuttinged@NDUNick

In this Episode of Stonedcation Podcast Ken and N'Dea connect with their roommate to talk about the Solar Eclipse and the Charlottesville marches.

Neben den anerkannten Risikofaktoren Alkohol und Rauchen gewinnt die individuelle Suszeptibilität, als zusätzlicher Risikofaktor für die Entwicklung von Kopf-Hals-Tumoren zunehmend an Bedeutung. Eine genetische Disposition zur DNA-Instabilität oder präformierte Defizite im Bereiche der DNA-Reparaturmechanismen begünstigen das Auftreten und die Persistenz kritischer Mutationen. Durch diese „endogenen“ Risikofaktoren wird eine Tumorenstehung begünstigt, so dass manche Personen, bei gleicher Expositionsstärke und -dauer gegenüber exogenen kanzerogenen Einflüssen, leichter ein Karzinom entwickeln, als andere. In der vorliegenden Arbeit sollte untersucht werden, ob Unterschiede in der Mutagensensitivität und/oder der DNA-Reparaturkapazität zwischen einer Versuchsgruppe aus Patienten mit einem Karzinom des oberen Aerodigestivtraktes und einer gesunden Probantengruppe feststellbar sind. Die beiden Gruppen wurden nach Geschlecht, Alter, Tabak- und Alkoholkonsum abgeglichen. Das Kollektiv der Karzinompatienten umfasste 20 Personen, die an einem oropharyngealen Karzinom erkrankt waren. Der Kontrollgruppe gehörten ebenfalls 20 Personen an, die jedoch alle frei von einem Tumorleiden waren. Perioperativ wurden zur Testung jeweils 20 Schleimhautproben gewonnen. an Lymphozyten standen aus beiden Gruppen jeweils 15 Proben zur Verfügung. Die anerkannt karzinogenen Inhaltsstoffe des Tabakrauchs Benzo[a]pyren, BPDE, NDEA, NNN, NNK, NDEA wurden als Testsubstanzen verwendet, um Schäden an der DNA zu induzieren. MNNG und die Lösungssubstanz DMSO dienten als Positiv- und Negativkontrolle. Schleimhautzellen und Lymphozyten wurden jeweils für 60 Minuten mit den genannten Fremdstoffen inkubiert. Der Reparaturversuch wurde ausschließlich mit NDEA durchgeführt. Nach Auswaschung des Fremdstoffes wurde den Schleimhautzellen 15 und 30 Minuten und den Lymphozyten 15, 30 und 60 Minuten Zeit zur Reparatur entstandener DNA-Schäden gewährt. Zur quantitativen Darstellung der fremdstoffinduzierten DNA-Schädigungen und Reparaturleistung wurde der Comet Assay benutzt. Alle getesteten Substanzen zeigten im Vergleich zur Kontrollsubstanz DMSO ein signifikantes Schädigungsniveau. Die Ergebnisse der Versuche zur Mutagensensitivität zeigten eine signifikant höhere Schädigung der Schleimhautzellen der Tumorgruppe durch NNN. In den weiteren Versuchen zur Mutagensensitivität konnte durch keine weitere Substanz, weder in Schleimhautzellen, noch in Lymphozyten, eine Schädigung ausgelöst werden, die einen signifikanten Unterschied zwischen Tumor- und Kontrollgruppe aufzeigt. Für Schleimhautzellen und Lymphozyten konnte ein Ansteigen der DRC im zeitlichen Verlauf von 0 bis 30, bzw. 0 bis 60 Minuten erfasst werden. Ein signifikanter Unterschied zwischen Versuchs- und Kontrollgruppe bestand nicht. Alle benutzen Testsubstanzen verursachen nachweisbare DNA-Schäden in unterschiedlicher Stärke und Homogenität. Sowohl in Lymphozyten, als auch Epithelzellen fand unter den eingesetzten In-vitro-Bedingungen eine zeitabhängige zunehmende Reparatur der geschädigten DNA statt. In der statistischen Auswertung der Ergebnisse konnte ausschließlich für das Agens NNN (p = 0,04) eine erhöhte Sensitivität der Schleimhautzellen von Karzinompatienten nachgewiesen werden. Zur Bestätigung dieses Ergebnisses müssen weitere Versuche folgen. Insgesamt ließ sich die Hypothese einer unterschiedlichen Mutagensensitivität und DNA-Reparaturkapazität beim Vergleich von Patienten mit einem Karzinom des Kopf-Hals-Bereiches und in der Population der vorliegenden Arbeit nicht bestätigen.

Recently I came across a more soulful production of J Dilla than I'm used to on a vinyl called "Jay Deelicious: The Delicious Vinyl Years (95-98)". Most of the songs featured on here are remixes of The Pharcyde songs but there are a couple of soul/R&b songs with The Brand New Heavies and N'Dea Davenport. Dilla's music lives on.

Die Schleimhaut des nasalen Raums stellt das primäre Kontaktorgan für inhalierte Stoffe dar. Um den Körper vor toxischen Wirkungen zu schützen und den Geruchssinn zu unterstützen, besitzen die Epithelzellen der respiratorischen Anteile erhebliche metabolische Kompetenz. Interindividuelle Unterschiede im Fremdstoffmetabolismus können in Verbindung mit einer beruflichen Exposition gegenüber inhalativen Karzinogenen zur Entstehung von Malignomen des sinonasalen Raums führen. Um gefährliche Stoffe und gefährdete Populationen anhand von in-vitro-Versuchen identifizieren zu können, wurde ein dreidimensionales Kultursystem humaner nasaler Mukosa vorgestellt, das die Verhältnisse in vivo möglichst realistisch abbildet. Dazu wurden Resektate humaner nasaler Mukosa in 1 mm3 großen Fragmenten unter optimierten Umweltbedingungen kultiviert. Innerhalb einer Woche bildeten sich daraus vollständig epithelisierte Miniorgane mit physiologischen histomorphologischen und funktionellen Eigenschaften. Um die Leistungsfähigkeit der Miniorgane zu evaluieren, wurden sie ein- oder mehrfach gegenüber den bekannt genotoxischen Substanzen Natriumdichromat, N-Nitrosodiethylamin (NDEA) und N-Methyl-N’-nitro-N-nitrosoguanidin (MNNG) exponiert. Parallel dazu wurden zum Vergleich Einzelzellsuspensionen mit diesen Stoffen inkubiert. Die induzierten genetischen Schäden wurden mit Hilfe der alkalischen Version des Einzelzell-Mikrogelelektrophorese-Assay quantifiziert. Der Anteil apoptotischer Vorgänge an hohen DNS-Schäden im Einzelzell-Mikrogelelektrophorese- Assay wurde durch den Annexin-V-Affinitätstest erfasst. Um den Erhalt der metabolischen Kompetenz der Zellen der Miniorgane im Verlauf der Kultivierung zu belegen, wurde die Konzentration von Cytochrom P450 2A6, einem Schlüsselenzym im Metabolismus zahlreicher inhalativer Giftstoffe, durchflusszytometrisch bestimmt. Die Miniorgane blieben über den Kulturzeitraum strukturell und funktionell intakt. Die einmalige Exposition gegenüber Natriumdichromat und MNNG verursachte erhebliche genetische Schäden, die bei wiederholter Inkubation trotz 48stündiger Reparaturphasen weiter zunahmen. Im Falle von Natriumdichromat stieg analog dazu der Anteil apoptotischer Zellen rasant an. Bei MNNG war dagegen keine erhöhte Apoptoserate nachweisbar. Die wiederholte Inkubation der Miniorganen mit NDEA ergab weder einen signifikanten genotoxischen Effekt, noch einen Anstieg der Apoptoserate, obwohl das für die Aktivierung von NDEA entscheidende Apoenzym Cytochrom P450 2A6 über den gesamten Untersuchungszeitraum in den Zellen nachgewiesen werden konnte. Im Vergleich der DNS-Fragmentierung erwiesen sich die in Suspension inkubierten Einzelzellen als empfindlicher gegenüber der Wirkung von Natriumdichromat und MNNG. Miniorgane nasaler Mukosa sind für toxikologische Studien optimal geeignet, da sie Untersuchungen an humanem Zielgewebe über einen längeren Untersuchungszeitraum erlauben. Dies eröffnet vielfältige Versuchsanordnungen hinsichtlich Expositionsfrequenz und Reparaturintervallen. Zudem erscheinen die Kulturen ausreichend robust, um zukünftig verschiedene realistische Expositionsmodelle, wie Begasungsanlagen und komplexe Mischungen, einzusetzen.

Umwelt- und Arbeitsstoffe stellen wichtige Faktoren bei der Kanzerogenese im menschlichen Körper dar. In der vorliegenden Arbeit wurden einige Vertreter von Umweltstoffen ausgewählt und auf ihre kanzerogene Wirkung hin untersucht: N-Nitrosodiethylamin (NDEA) für die Nitrosamine, Natriumdichromat (Na2Cr2O7) für die Chromverbindungen, Mono(2-Ethylhexyl)-Phthalat (MEHP) für die Phthalate und Benzo[a]pyren-Diolepoxid (BPDE) für die polyzyklischen Kohlenwasserstoffe. Als Negativkontrolle diente Dimethylsulfoxid (DMSO) und als Positivkontrolle N-Methyl-N‘-Nitro-N-Nitrosoguanidin (MNNG). Da viele dieser Stoffe über die Atemwege aufgenommen werden, ist die Schleimhaut des oberen Aerodigestivtraktes besonders exponiert. Als Untersuchungsmaterial diente deshalb humane nasale Schleimhaut. Um möglichst lebensnahe Bedingungen zu schaffen, wurden aus dieser ca. 1mm3 große Miniorgane gewonnen, die über eine Woche kultiviert wurden, was zu einer vollständigen Epithelialisierung führte. Die im natürlichen Zellverband verbliebenen Zellen konnten daraufhin mehrmals mit Fremdstoffen inkubiert werden. Die dazwischenliegenden Zeitintervalle ließen Reparaturvorgänge zu. Die Schädigungsmuster von Miniorganzellen wurden auch mit denen von Einzelzellen verglichen, die vor der Inkubation separiert worden waren. Dabei wurden sowohl Einzelzellen aus Frischbiopsaten und als auch Einzelzellen aus Miniorganen nach 7-tägiger Kultivierung getestet. Zur quantitativen Schädigungsanalyse wurde die alkalische Einzelzell-Mikrogelelektrophorese (Comet Assay) angewandt, bei der es zu einer Wanderung von gelösten DNA-Bruchstücken im elektrischen Feld kommt. Diese Wanderung konnte durch anschließende Anfärbung unter dem Fluroszenzmikroskop sichtbar gemacht werden. Die Ergebnisse zeigten unterschiedliche Fragmentierungen der DNA nach einmaliger und dreimaliger Fremdstoffinkubation: Die DNA-Schädigungen der Miniorgane blieben nach ein- und dreimaliger Inkubation mit NDEA und MEHP auf gleichem Niveau. Dagegen traten bei jeder Inkubation mit Na2Cr2O7, BPDE und MNNG zunehmende DNA-Fragmentierungen auf. Die aus Frischbiopsaten gewonnenen Einzelzellen zeigten bei jeder der getesteten Substanzen eine erhöhte Empfindlichkeit. Der direkte Vergleich zwischen Einzelzellen und Miniorganen nach 7 Tagen ergab eine gleich hohe Schädigung für NDEA. Bei den anderen getesteten Stoffen wiesen die Einzelzellen höhere DNA-Fragmentierungen auf. Es konnte gezeigt werden, dass alle getesteten Stoffe Schädigungen an der Erbsubstanz in Form von Einzelstrangbrüchen hervorrufen. Im Vergleich zwischen Miniorganen und Einzelzellen wiesen Einzelzellen überwiegend eine höhere Empfindlichkeit gegenüber Fremdstoffen auf als die im epithelialen Strukturverband belassenen Zellen der Miniorgane. Das Miniorganmodell bot mehrfache Inkubationsmöglichkeiten und ließ so Reparaturphasen zu. Durch die Verwendung von Miniorgankulturen können lebensnahe Bedingungen geschaffen werden, die die Vorgänge im menschlichen Körper besser widerspiegeln als ein Einzelzellmodell. Die Verwendung von Miniorgankulturen eignet sich somit zur Untersuchung der metabolischen Kompetenz von Zellen und der DNA-Reparaturmechanismen. Dadurch kann die hier vorgestellte Methode zur Prävention von malignen Tumoren des oberen Aerodigestivtraktes einen wichtigen Beitrag leisten. Auch die hier erstmals in Verbindung mit Miniorganen eingesetzte alkalische Einzelzell-Mikrogelelektrophorese (Comet Assay) erwies sich als geeigneter Kurzzeittest zur Schädigungsanalyse. Das gezeigte Modell ermöglicht die Weiterentwicklung einer Screeningmethode für die Genotoxizität von Umweltstoffen unter Berücksichtigung individueller Empfindlichkeiten.

Genotoxic effects of xenobiotics are a possible step in tumor initiation in the mucosa of the upper aerodigestive tract. Using the comet assay, detecting genotoxicity in human tissue has been restricted to single incubations in vitro, but in vivo most xenobiotics harm their target in a repetitive or chronic manner. Therefore, we propose a model, which provides repetitive incubations in human upper aerodigestive tract mucosa cultures. Samples of human inferior nasal turbinate mucosa (n = 25) were cultured according to a modified version of a technique originally described by Steinsvag. On day 1 fresh samples and on days 7, 9 and 11 organ cultures were incubated with N-nitrosodiethylamine (NDEA), sodium dichromate (Na2Cr2O7) and N'-methyl-N-nitro-N-nitrosoguanidine(MNNG). Mucosa samples and organ cultures, respectively, underwent a modified comet assay on days 1, 7 and 11. Genotoxicity could be shown for NDEA, Na2Cr2O7 and MNNG on days 1, 7 and 11. Duration of tissue culture and repetitive incubations did not significantly influence the results for NDEA. Nevertheless, Na2Cr2O7 and MNNG caused higher genotoxic effects on cultures subjected to the comet assay on day 11. This model may help to assess genotoxic hazards posed by environ mental pollutants that have a cumulative character in repetitive or chronic exposure in vivo. Copyright (C) 2001 S. Karger AG, Basel.