Podcasts about mucosa

In today's episode, we detail the enteric nervous system and regulation of gastrointestinal motility. We discuss factors including dysautonomia, stress, microbial overgrowth, and more, with regards to potential effects upon gastrointestinal motility. We further detail symptoms of altered GI motility. Topics:1. Introduction to Gastrointestinal Motility- Orchestrated contraction of smooth muscles that propel contents along the digestive tract.  - Roles in mixing, absorption, and preventing bacterial overgrowth.- Disruptions in motility. 2. The Enteric Nervous System (ENS) and Its Role- Myenteric and submucosal plexus.- Coordinating contractions and relaxations for effective motility. - Mucosa includes epithelium, lamina propria, and muscle.  - Submucosa houses the submucosal plexus.  - Muscularis externa. - Inner circular and outer longitudinal muscle layers with the myenteric plexus in between.   3. The Role of Interstitial Cells of Cajal (ICCs)- Specialized pacemaker cells in muscular layers  - Generate slow-wave electrical activity to synchronize smooth muscle contractions  - Critical for peristalsis.- Work with neural inputs to fine-tune gut motility   4. Dysautonomia and Its Impact on Gut Motility- Dysfunction of the autonomic nervous system (ANS)  - Motility impacts- Microbial overgrowth, SIBO 5. Gastrointestinal Dysmotility- Neurological dysregulation - Structural abnormalities and smooth muscle dysfunction  - Hormonal imbalances - Microbial overgrowth - Autoimmunity  6. The HPA Axis- Hypothalamus, pituitary gland, adrenal glands  - Central to the stress response and interlinked with gut function  - The amygdala and PVN of the hypothalamus  - CRH stimulates ACTH, leading to cortisol release from adrenal glands   7. Cortisol and Gut Barrier Function- Cortisol is a glucocorticoid that modulates immune function and gut physiology  - Chronic cortisol exposure can impair tight junction (TJ) integrity  - Increases paracellular permeability and allows passage of antigens and endotoxins   8.Stress-Induced Changes in Gut Motility- Slow gastric motility - Increased colonic motility  9. Symptoms of GI Dysmotility10. Addressing Root Cause(s)Thank you to our episode sponsor:1. Shop ⁠⁠⁠⁠⁠⁠⁠Fresh Press Farms⁠⁠⁠'⁠⁠⁠⁠⁠⁠⁠⁠Peach Cider Vinegar⁠⁠⁠⁠ at Sprouts locations nationwide, and check out their full collection ⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠. Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Invitada: Dra Estefanía Retama Carranza, Patóloga bucal https://www.instagram.com/dentistaalmicroscopio/ #mucosaoral #mucosabucal #patologabucal #patologabucalsonora #patologobucalsonora #odontologia #patologiabucal #patologiaoral #odontoblog #odontoblogmx #productosdañinosparaboca

Dr. Lisa Pomeroy is a traditional naturopath with extensive training in functional medicine, lab test interpretation, and gut microbiome balancing through the Kalish Institute, The Microbiome Restoration Center, Functional Diagnostic Nutrition (FDN), and other organizations. In addition to being a graduate of the Kalish Institute Mentorship Program, Lisa is a Certified Microbiome Analyst through Dr. Jason Hawrelak. Currently, she works as a clinical consultant for Diagnostic Solutions Laboratory, and educates health practitioners on functional lab test interpretation through her business Pomeroy Institute For Functional Nutrition. In this episode, Dr. Pomeroy talks about the differences in the various gut health tests, how GI-MAP test compares to other tests and what some of the insights the DUTCH test can provide are. Learn more about Dr. Pomeroy and her training courses for health practitioners on Interpreting the GI-MAP Test and Interpreting the DUTCH Test here: https://www.pomeroyinstitute.com/ Get 15% off Peluva minimalist shoe with coupon code COACHTARA here: https://peluva.com/ CHAPTERS: 0:00 Intro 4:05 What the DUTCH test is 8:23 Phase II estrogen metabolism 12:13 Dr. Lisa's gut health background 17:30 Brain fog and gut health connection 20:20 Migraines 22:35 Mucosa lining 25:10 SIBO 28:57 Gut health testing 36:11 Gut health & hormones

In today's episode, we dive into the interplay between the gut and immune system, focusing specifically on the critical role of immunoglobulins in mucosal immunity. Immunoglobulins, specialized glycoproteins synthesized by B cells, serve as the frontline defenders within the gastrointestinal tract, where they neutralize pathogens and maintain immune homeostasis. We also explore the mechanisms by which these antibodies fortify the intestinal barrier and aid in preventing dysbiosis. We finish by going through tools for supporting immunoglobulins. Topics: 1. Introduction - Overview of the gut-immune axis and focus on immunoglobulins. - How low levels of immunoglobulins can contribute to dysbiosis. 2. What Are Immunoglobulins? - Immunoglobulins (Igs) are glycoproteins produced by B cells. - They play a critical role in recognizing and neutralizing pathogens. - Antigen-binding sites for specific targeting. - Essential for immune homeostasis and pathogen elimination. 3. Immunoglobulins' Role in the Gut - Protect mucosal surfaces exposed to antigens. - B cells differentiate into plasma cells, and secrete immunoglobulins into the gut lumen. 4. Layers of the Intestinal Lining - Intestinal lumen is covered by a protective mucus layer. - Mucosa consists of epithelial cells, including mucus-secreting goblet cells. - Lamina propria beneath the epithelium is rich in immune cells. - Submucosa beneath mucosa. 5. The Function of the Mucus Layer - Acts as a physical barrier against pathogens. - Functions as a biochemical barrier by housing antimicrobial peptides and immunoglobulins. - Primarily composed of mucins secreted by goblet cells. - Goblet cells release mucins in response to stimuli, forming gel-like mucus. 6. Introduction to Secretory Immunoglobulin A (sIgA) - sIgA is the most abundant immunoglobulin in mucosal secretions. - Forms a protective barrier in the mucus layer. - Plays a critical role in immune exclusion by trapping and neutralizing pathogens. - Helps maintain non-inflammatory defense at mucosal surfaces. 7. Production of Secretory IgA - Plasma cells in the lamina propria secrete IgA. - IgA binds to receptors on epithelial cells and is transported across to the gut lumen. - sIgA to neutralize pathogens effectively within the mucus layer. 8. Functions of Secretory IgA in the Gut - Binds to antigens like bacterial walls, viruses, and toxins. - Traps antigens in the mucus to prevent adherence to epithelial cells. - Provides immune exclusion, reducing pathogen access to the gut lining. - Maintains mucosal barrier integrity to prevent inflammation. 9. Impact of Low sIgA Levels - Contributes to dysbiosis by allowing pathogenic bacteria to proliferate. - Intestinal hyperpermeability. - Increased risk of intestinal inflammation and infections. 10. Comparison with Other Immunoglobulins: IgG and IgM - IgG is most abundant in blood. - IgM is produced early in immune responses. - IgM can also be secreted into the gut lumen in IgA deficiency. 11. Immunoglobulin Supplements - IgG supplements. - Colostrum: IgG to help neutralize pathogens. - Supports gut barrier integrity. 12. Supporting Immunoglobulin Levels - Colostrum - Probiotics, prebiotics - Vitamin A - Zinc 13. Conclusion - Immunoglobulins, intestinal health, and immune balance. Thanks for tuning in! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Espacio creado para desarrollar las diferentes vivencias y experiencias a lo largo de nuestras vidas, sensaciones, bienestar, medicina, invitados y más se mezclan en este lugar. Tema: Gastroligadura mucosa endoscópica Invitado: Dr. Fernando Vargas - Dr Ylemar Albarra Conduce Dr. Mario Ojeda COVID19​​​​​​​ #BuenVivir​​​​​​​​​ #RadioHoy​​​​​​​​​ #Chile​​​​​​​​​ Todos los Miércoles de 21:00​​​​​​​​​ a 22:00​​​​​​​​​ Hrs este y más programas en un solo lugar ingresando a www.radiohoy.cl

 In this episode, Dr. Wiegand focuses on the urethra for males and females and provides an understanding of intermittent catheterization of the bladder, associated with incomplete bladder emptying. He highlights the importance of patients remaining compliant with bladder emptying protocol. Dr. Wiegand discusses different treatment options for urinary retention including intermittent catheterization and surgical reconstruction of the urethra.  Guest bio: Dr. Luke Wiegand is a board-certified urologist with Orlando Health Medical Group Urology specializing in reconstructive urology. Sought after for second opinions and complex case referrals, he strives to communicate honestly and directly with his patients to help put them at ease and achieve their goal of returning to their normal lives.  Dr. Wiegand earned his medical degree and completed his urology residency at the University of South Florida Morsani College of Medicine in Tampa. He was chief resident in his final year. Dr. Wiegand performed his fellowship in reconstructive urology at Washington University in St. Louis, where he supervised residents in general urology and reconstructive urologic procedures. He serves as assistant editor of the Video Journal of Prosthetic Urology. He is the author of several medical textbook chapters and is a frequent contributor to peer-reviewed journals.  Dr. Wiegand is board-certified by the American Board of Urology. His professional memberships include the American Urologic Association, Florida Urological Society, and the Society of Genitourinary Reconstructive Surgeons.  Tags: ##bladder, #urology. #whydoineedtodrainmybladder, #whathappensifIskipcatheterization, #utiprevention, #compliancewithbladdercatheterizaion, #teachingcatheterization, #urinaryretention, #bladderemptying, #whyintermittentcatheterization,  

Espacio creado para desarrollar las diferentes vivencias y experiencias a lo largo de nuestras vidas, sensaciones, bienestar, medicina, invitados y más se mezclan en este lugar. Invitados: Dr. José Rojas - Dr. Freddy Febres - Dr. Fernando Vargas Tema: Ligadura Mucosa Gástrica como alternativa novedosa para manejo de la obesidad Conduce Dr. Mario Ojeda y Orlando Pulgar COVID19​​​​​​​ #BuenVivir​​​​​​​​​ #RadioHoy​​​​​​​​​ #Chile​​​​​​​​​ Todos los Miércoles de 21:00​​​​​​​​​ a 22:00​​​​​​​​​ Hrs este y más programas en un solo lugar ingresando a www.radiohoy.cl

¡Una mucosa nasal saludable es la mejor barrera contra los virus! Siguiendo algunas reglas sencillas, la nariz puede cumplir perfectamente su cometido.

L'impero del ventre e i suoi disastri

Dr Linda Baker visits the studio as we consider birth defects of the vagina... and the buccal mucosa vaginoplasty. Around 1 in 4,000 girls experience these birth defects, and using tissue from inside the mouth is less invasive than traditional repairs. We hope you can join us!

In today's episode, we will delve into a research-backed candida toolkit, exploring the cellular structure of candida microbes and presenting scientifically supported strategies to target and eliminate candida overgrowth. Thank you so much for tuning in! Topics: 1. Understanding candida - Overview of candidiasis and Candida albicans - Candida albicans as part of the body's microbiota 2. Symptoms and related conditions of candida overgrowth - Digestive symptoms (bloating, gas, diarrhea, constipation) - Fatigue and recurrent yeast infections - Cognitive and mood symptoms (brain fog, difficulty concentrating, mood swings) - Skin and nail infections, sugar cravings 3. Candida's metabolic pathways and adaptability - Fuel sources for Candida albicans (glucose, fructose, galactose) - Cell wall composition and remodeling - Moonlighting proteins and adaptability - Transition from yeast to hyphal form 4. Strategies to address candida overgrowth - Blocking fungal cell wall and immune evasion Beneficial gut bacteria (L. rhamnosus, L. johnsonii) Echinocandin antifungal medications? Caprylic acid (found in coconut oil) - Blocking fungal cell adhesion Beneficial gut microbes antagonizing candida adhesion sites Rosemary as an adhesion inhibitor LL-37 peptide as an adhesion blocker - Blocking biofilm formation or destroying biofilms Short-chain fatty acids produced by beneficial gut bacteria Carvacrol and thymol (found in oregano) - Blocking the yeast to hyphal transition Butyrate (short-chain fatty acid) - Blocking key pathways for candida albicans cell proliferation or metabolism Azole antifungal medications? Chinese skullcap Allicin (found in garlic) Low-sugar or anti-candida diet - Enhancing anti-fungal immune activity Butyrate (boosting macrophage antifungal activity) 5. Conclusion - Summary of candida strategy toolkit - Importance of a holistic approach to address candida overgrowth Thanks for tuning in! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness, or use the link: ⁠https://www.instagram.com/synthesisofwellness/⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠synthesisofwellness.com⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠linktr.ee/synthesisofwellness⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Discover groundbreaking research on bacteria therapy, probiotic therapy, microbiome transplants, and which oils and lotions have been shown to kill staph aureus overgrowth on the skin. ​ In this episode, we also cover: ​ - The benefits of lemon myrtle oil, pine tar, and colophonium into lotions. - How R.Mucosa strains can help in improve eczema symptoms - The most effective oils and lotions that kill staph auerus on the skin  - Lanolin as an allergy for many eczema patients   ​ Join the Eczema Conquerors Podcast today and take the first step towards healthier, happier skin. The key to unlocking the secret to eczema relief is just a click away!  ​ ​ ​ *Research papers mentioned:  ​ Assessing the effects of common topical exposures on skin bacteria associated with atopic dermatitis - https://onlinelibrary.wiley.com/doi/full/10.1002/ski2.41 ​ https://www.niaid.nih.gov/news-events/probiotic-skin-therapy-improves-eczema-children-nih-study-suggests ​ Exposure to isocyanates predicts atopic dermatitis prevalence and disrupts therapeutic pathways in commensal bacteria - https://www.science.org/doi/10.1126/sciadv.ade8898 ​ Association of frequent moisturizer use in early infancy with the development of food allergy - https://pubmed.ncbi.nlm.nih.gov/33678253/ ​ Assessing the effects of common topical exposures on skin bacteria associated with atopic dermatitis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555759/ ​ First-in-human topical microbiome transplantation with Roseomonas mucosa for atopic dermatitis https://pubmed.ncbi.nlm.nih.gov/29720571/

A Universidade do Minho em parceria com a Universidade Paris-Cité publicou em Março um estudo que dá conta que mesmo largos meses após os pacientes estarem curados do vírus, aqueles que apresentam ainda sintomas da doença, ou seja covid longo, têm uma deficiência imunológica, estando o vírus instalado na intestino. Até três meses após ter sofrido de covid-19, a Organização Mundial de Saúde estima que um em cada dez pacientes apresentem ainda sintomas da doença, classificando esta situação como um quadro de covid longo. Este covid pode ser caracterizado com diferentes sintomas como tosse persistente, fadiga, confusão mental ou problemas de memória entre outros.De forma a tentar procurar as causas desta doença, a Universidade do Minho, em parceria com Universidade Paris-Cité, estudou 127 doentes que já tinha acompanhado na primeira contaminação com covid-19 de forma a compreender se quem ainda apresentava sintomas tinha alguma coisa em comum, tendo encontrado o vírus na mucosa intestinal de diferentes pacientes.Ricardo Silvestre, investigador principal do Instituto de Investigação em​ Ciências da Vida e Saúde da Universidade do Minho, explicou em entrevista à RFI como levou a cabo este estudo com a sua equipa."Já em 2022 começou a perceber-se que havia um conjunto de doentes que mantinham uma série de sintomas ao longo do tempo, depois de terem a doença aguda, e isso permitiu-nos voltar a contacta-los seis meses depois, voltar a colher sangue, caracteriza-los e aí colocámos a hipótese que a existência destes sintomas de covid longo podia estar associada com uma disfunção imunológica e basicamente o nosso estudo permitiu avaliar que os doentes associados aos sintomas do covid longo têm uma disfunção imunológica que nós neste artigo associamos a uma persistência do vírus na muscosa intestinal", explicou Ricardo Silvestre.Até agora, esta é uma doença difícil de diagnosticar já que possui sintomas muito diversos que podem assemelhar-se a uma gripe, mas ir até sintomas neurológicos, sendo que até agora, os médicos têm conseguido apenas tratar os sintomas, mas não a origem deste covid prolongado. As conclusões deste estudo podem, finalmente, mostrar caminhos para curar o covid longo."O covid longo está associado a uma persistência viral nas mucosas, nomeadamente na parte intestinal e pode-se sugerir, para estudos futuros, tratar estes doentes com antivirais. A outra perspectiva é que como o diagnóstico é sempre feito por exclusão, com pacientes que tiveram covid há menos de três meses e cujos sintomas se mantêm já há dois meses ou mais e na exlusão de outros problemas, eles são caracterizados como tendo covid longo. O facto de termos encontrado biomarcados, da presença de um conjunto de anti-corpos específicos pode servir para fazer um diagnóstico não por exclusão, mas por positividade", detalhou o investigador.Ricardo Silvestre concluiu ainda que a vacina continua a ser muito importante, mesmo nos casos de covid longo, havendo menos casos quando as pessoas são vacinadas.

En el podcast de hoy os hablo de las 2 subfases que nos quedaron pendientes la semana pasada:Recuperar las secreciones digestivas mediante la suplementación de algunos alimentos y suplementos de farmacia, como el jengibre, el umeboshi, Iberogast (medicamento), la menta piperita y algunas infusiones naturales.Recuperar el complejo motor migratorio, es decir, nuestro movimientos de limpieza y vaciado que ocurren en el estómago y el intestino delgado cuando no comemos y que se ponen en marcha entre 2 o 3 horas después de haber comido. Estos movimientos tienen como objetivo limpiar el aparato digestivo de restos de comida y otras sustancias de desecho. En el podcast os explico cómo podemos favorecer el correcto funcionamiento de estos movimientos de limpieza.

Cuando realizamos el tratamiento para erradicar SIBO, no solamente hablamos de la fase de limpieza o toma de antibióticos (convencionales o herbáceos), sinó que también hacemos referencia a esa fase de recuperación de la mucosa intestinal y de la capa de moco protector. Es importante realizar correctamente todas las fases del tratamiento médico, combinado como ya sabéis con una dietoterapia baja en FODMAP's. Para esta fase de recuperación de la mucosa intestinal deberemos haber terminado la toma de antibióticos tal y como nos los haya pautado el médico especialista que esté tratando nuestro SIBO e iniciar enseguida esta nueva fase, que pasa por diferentes subfases, entre las que principalmente se encuentran la “recuperación de la microbiota intestinal” y la “reparación de la permeabilidad intestinal y la capa de moco protector” (entre otras subfases que trataremos en próximos podcast).

This month's Fast Facts: Perio Edition will be a series that Katrina refers to as... Are You Smarter Than A Dental Hygiene Student? In this episode we review the Oral Mucosa and before you move past this thinking that you won't need this refresher, let us remind you that Oral Cancer screenings should be performed on each and every patient. Knowing what is "normal" for each tissue type is super important so please give this episode a listen. If you are an educator, please share this with a friend! Resources: More Fast Facts: https://www.ataleoftwohygienists.com/fast-facts/  Katrina Sanders Website: https://www.katrinasanders.com  Katrina Sanders Instagram: https://www.instagram.com/thedentalwinegenist/   

This month's Fast Facts: Perio Edition will be a series that Katrina refers to as... Are You Smarter Than A Dental Hygiene Student? In this episode we review the Oral Mucosa and before you move past this thinking that you won't need this refresher, let us remind you that Oral Cancer screenings should be performed on each and every patient. Knowing what is "normal" for each tissue type is super important so please give this episode a listen. If you are an educator, please share this with a friend! Resources: More Fast Facts: https://www.ataleoftwohygienists.com/fast-facts/  Katrina Sanders Website: https://www.katrinasanders.com  Katrina Sanders Instagram: https://www.instagram.com/thedentalwinegenist/   

Celiac disease is of the most common auto-immune diseases in the world. The only current treatment is maintaining a strict gluten-free diet. Join host, Geoff Wall, as he discusses the results of a phase 2 study investigating a novel pharmacologic treatment of Celiac disease. The GameChangerCeliac disease is common and has a myriad of symptoms. A new drug may offer a way for patients with Celiac disease to eat gluten without issue.Show Segments00:00 - Introductions00:50 - The Effects of Celiac Disease03:45 - Why Celiac Causes Problems09:08 - Latiglutenase Study Background14:48 - The GameChanger: Latiglutenase Study Results19:11 - Connecting to Practice21:31 - Closing RemarksHostGeoff Wall, PharmD, BCPS, FCCP, CGPProfessor of Pharmacy Practice, Drake UniversityInternal Medicine/Critical Care, UnityPoint HealthReferences and ResourcesMurray JA, Syage JA, Wu TT, et al. Latiglutenase Protects the Mucosa and Attenuates Symptom Severity in Patients With Celiac Disease Exposed to a Gluten Challenge. Gastroenterology. 2022 Dec;163(6):1510-1521.e6. doi: 10.1053/j.gastro.2022.07.071. Epub 2022 Aug 2. PMID: 35931103; PMCID: PMC9707643.Redeem your CPE or CME hereCPE (Pharmacist)CME (Physician) Get a membership & earn CE for GameChangers Podcast episodes (30 mins/episode)Pharmacists: Get a membershipPrescribers: Get a membershipCE InformationLearning ObjectivesUpon successful completion of this knowledge-based activity, participants should be able to:1. Describe the extraintestinal manifestations of Celiac disease2. Discuss the Murray et al study and its implications in patients with Celiac disease0.05 CEU/0.5 HrUAN: 0107-0000-23-024-H01-PInitial release date: 01/16/2023Expiration date: 01/16/2024Additional CPE and CME details can be found here.Follow CEimpact on Social Media:LinkedInInstagramDownload the CEimpact App for Free Continuing Education + so much more!

Apesar de apresentar poucos sintomas ou até mesmo nenhum, a cor amarelada da pele e olhos, febre e mal-estar podem indicar algum tipo de hepatite

Apesar de apresentar poucos sintomas ou até mesmo nenhum, a cor amarelada da pele e olhos, febre e mal-estar podem indicar algum tipo de hepatite

Apesar de apresentar poucos sintomas ou até mesmo nenhum, a cor amarelada da pele e olhos, febre e mal-estar podem indicar algum tipo de hepatite

Es conveniente recordar que la vulva está constituida por estructuras muco cutáneas que conforman los genitales femeninos externos, abarca desde el pubis en la parte anterior hasta el periné en la posterior y esta limitada delantera lateral por los pliegues crurales.

Continuan los estudios para la lucha contra la COVID-19, en este caso sobre las vacunas que se administren como un aerosol para la nariz o unas gotas o pastillas para la boca. El doctor Elmer Huerta da más detalle.

Continuan los estudios para la lucha contra la COVID-19, en este caso sobre las vacunas que se administren como un aerosol para la nariz o unas gotas o pastillas para la boca. El doctor Elmer Huerta da más detalle.

Did you know that the pig's microbiota has more than 400 species of fungi and bacteria yielding approximately 10 times more cells than those in the pig's body? These microbes are at the nexus of health and productivity as they communicate with each other and with the pig's organs and systems. Phileo by Lesaffre is committed to pushing the boundaries of animal health, nutrition, and well-being to better nourish and feed our world. United with our partners, we are key influencers in the quest to discover, define, and manipulate the pig's microbiome to significantly improve pig lifetime health and productivity. This podcast series is provided to help increase your understanding of these exciting and thought-provoking topics.

Dr. William Oliveros. Especialista en Hematología. Tema a tratar Causas de sangrados en la mucosa y la piel de los niños.

In this episode, Dr. Jerby addresses the importance of treating the 3 M's: The Microbiome, the Mucosa, and the Modulation of the immune system. This approach is especially important when considering food and chemical sensitivities and intolerances. A good place to start for many people (but certainly not all) is with a good quality probiotic. In light of all the junk that passes as a "probiotic", Dr. Jerby lists his stringent criteria that a probiotic must meet to be added to the list of products that he recommends to his patients. If you're in need of more help, you can sign up for a free 15 minute phone consultation with Dr. Jerby to see if his treatment approach is a good fit for you. Sign up at drjerby.com.

No te pierdas nuestros vídeos en YOUTUBE: https://goo.gl/UZVh8N También puedes pedir información de las consultas ONLINE en el mail: lahorademiguelangel@solnaturaleza.es No Te pierdas nuestras Redes Sociales: TELEGRAMA --- https://t.me/joinchat/qFBH_8muGRhlNDI0

Todd's handler, Shout out Sierra Leon, Bhutan, Uganda, Howler Head Bourbon, Copperfit Socks, B.O. and pheromones, Dave's toe socks, Top Three Facts You Didn't Know You Needed to Know, 8 minute poop, Chinese Food Carton, Rainbow Shit, No principles, Paqui Chips One Chip Challenge, Cry Time Tonic, Checking In, Tikashi 69, Mucosa, Church Gigolo, Smarmy, Lawsuit Shopper App, Road Rage, Sequined Hard Body

This episode is hosted by Dr. Thomas Slavin (T.J.) and features Dr. Eduardo Vilar-Sanchez. Dr. Vilar-Sanchez is a medical oncologist at MD Anderson Cancer Center. Together they discuss “Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa,” which was published in Gut and found here: https://pubmed.ncbi.nlm.nih.gov/32641470/ This episode was recorded on March 26, 2021 and reflects expert opinion at the time of the recording.

Gracias por seguir con nosotros, hoy en conciencia curativa biológica tenemos la segunda parte de nuestro tema: Nariz y mucosa nasal desde la ccb 👃🏻Cuidados en la nariz 🤧Detectar síntomas 😷Prevenir procesos de enfermedad 🧬Sistema autogenetico

Continuamos con nuestra programación del día de hoy en ´´conciencia curativa biológica. Hablaremos sobre: Nariz y mucosa nasal desde la CCB acompáñanos a descubrir de que es trata estamos seguros que te interesara. 🩺Síndrome de dirk hamer 🩺Como ocurre el DHS La Conflictolisis 👨🏻‍⚕️Las fases de curación

On this week's episode of Fast Facts - Perio Edition your host, Katrina Sanders, RDH talks to us about cells of the Oral Mucosa!    Quotes:    “This renewal or basal layer that continues to renew, we believe, turns over approximately every 10 days, whereas skin, for example, has a turnover rate of 28 days.”   “It's important to note that there are several different types of cells located within the oral epithelium, all of which are there and built to protect the underlying structures.”   Resources:   DentistRX: https://www.dentistrx.com  More Fast Facts: https://www.ataleoftwohygienists.com/fast-facts/    Katrina Sanders Website: https://www.katrinasanders.com  Katrina Sanders Instagram: https://www.instagram.com/thedentalwinegenist/

On this week’s episode of Fast Facts - Perio Edition your host, Katrina Sanders, RDH talks to us about cells of the Oral Mucosa!    Quotes:    “This renewal or basal layer that continues to renew, we believe, turns over approximately every 10 days, whereas skin, for example, has a turnover rate of 28 days.”   “It's important to note that there are several different types of cells located within the oral epithelium, all of which are there and built to protect the underlying structures.”   Resources:   DentistRX: https://www.dentistrx.com  More Fast Facts: https://www.ataleoftwohygienists.com/fast-facts/    Katrina Sanders Website: https://www.katrinasanders.com  Katrina Sanders Instagram: https://www.instagram.com/thedentalwinegenist/

Show Summary: Many people have gut dysfunction because we live in a very harmful and antagonistic society towards our gut biome. What’s worse is some scientists say that it is totally fine when it’s not. Childhood allergies are one of the harmful effects, and it has now tripled, which is why we have to be cautious of what is detrimental to our health.Other factors contributing to gut dysbiosis are stress, which increases inflammation and makes it a hostile environment for healthy bacteria to populate. Second is antibiotics and birth control. Third are the foods containing glyphosate, mostly found in bread, pasta, or processed food that uses wheat.Learn some practical steps on how to start restoring your gut biome with Juanique, as she also discusses her top six list of most inflammatory foods on the planet. Find out what superfoods you can eat to feed the good bacteria and help them grow exponentially.Important LinksGutsy Health WebsiteProvo Health InstagramGut Restoration3 Exceptional Highlights:We need to have the good bacteria be the king of the castles, we need more of them, the bigger the army, the more damage control they can do.Those born in the 90s I think are like five times more likely to get colon cancer in their 30s.You're going to take your probiotic with food so that as it goes in and germinates its spores out. It should have food to eat because it wants to grow.Show Highlights: What is the screening age for colon cancer now? Juanique 3:45There were a lot of very triggered people, and I apologize, but it basically said that those born in the 90s I think are like five times more likely to get colon cancer in their 30s.What is a healthy gut?Juanique 9:38 A healthy gut has a nice strong lining epithelium lining so it's not broken down.How does inflammation start?Juanique 14:30When we don't have enough healthy good bacteria to protect the mucous lining, the epithelial lining starts to break down. And when it breaks down with that mucosal lining starts to kind of dry up, and vaporize. What is rebalancing?Juanique 21:32Rebalance is stress management, yoga, exercising self-care, deep breathing, meditation. How to repair and repopulate?Juanique 21:47If you have insane gut dysbiosis if you potentially have cebo you might not want to start with this one. And I'll tell you why. Because there might be a lot of competition in your gut and it might make you more bloated and gassy. Don’t forget to subscribe to Apple Podcast and Spotify and get your discount at Provo Health using the code provohealth10.Support the show (https://www.mygutsyhealth.com/gutsy-family)Support the show (https://www.mygutsyhealth.com/gutsy-family)

Ortocast #68 – Mini-implantes em Mucosa Alveolar

Mucosa bucal. Segundo semestre. Episódio 2.

Varios artículos científicos publicados por revistas arbitradas indican que el nuevo coronavirus ingresa a nuestro organismo utilizando una proteína específica que se encuentra en la superficie de algunas de nuestras células. En marzo, la revista Science publicó una investigación que menciona el papel fundamental de la denominada enzima convertidora de angiotensina tipo 2, conocida como ‘ACE2’, por sus siglas en inglés. La proteína vírica del SARS COV-2, virus que provoca la enfermedad COVID-19, encaja en la ACE2 como un sistema de “llave- cerradura”, logrando así entrar a la célula e infectarla. La ciencia mundial continúa trabajando para encontrar respuestas sobre la unión de estas proteínas, porque allí estaría la clave para encontrar una vacuna contra la enfermedad y el desarrollo de fármacos para aliviar sus síntomas. Como un ejemplo más de trabajo científico multidisciplinario frente a esta pandemia, en Uruguay se está gestando una nueva línea de investigación entre la Facultad de Odontología de la Universidad de la República (Udelar), y el Instituto de Investigaciones Biológicas Clemente Estable (IIBCE), para determinar la presencia de células en la mucosa bucal y nasal capaces de interactuar con el nuevo coronavirus.

There will always be bugs and viruses around us. Even after the COVID-19 virus, it will always be something we deal with every fall and winter. The most important thing we can do is ALWAYS protect our immune system even when there isn't a pandemic! One way we do that is by keeping our Mucosa (mucus membrane) moist. In today's podcast Dr.Martin will discuss why this is so important! He will explain what mucosa is, why it is important as well as tips on how to keep it moist! He will also discuss vitamin A, cod liver oil and how much water we should be drinking daily. If you want to protect your immune system, you don't want to miss this episode!

La amenaza de los mosquitos - Germinar semillas - Mucosa intestinal y flora bacteriana - Entrevista María Ojeda (migraña crónica). ESPACIO BIO-LÓGICO Un lugar para ayudar a sintonizar con la lógica de vida. Para amigarnos con nuestro cuerpo y nuestro medio ambiente. Con la Conducción de Nestor Palmetti.

Sepsis is a complex of life-threating organ dysfunction in critically ill patients, with a primary infectious cause or through secondary infection of damaged tissues. The systemic consequences of sepsis have been intensively examined and evidences of local alterations and repercussions in the intestinal mucosal compartment is gradually defining gut-associated changes during sepsis. In the present review, we focus on sepsis-induced dysfunction of the intestinal barrier, consisting of an increased permeability of the epithelial lining, which may facilitate bacterial translocation. We discuss disturbances in intestinal vascular tonus and perfusion and coagulopathies with respect to their proposed underlying molecular mechanisms. The consequences of enzymatic responses by pancreatic proteases, intestinal alkaline phosphatases, and several matrix metalloproteases are also described. We conclude our insight with a discussion on novel therapeutic interventions derived from crucial aspects of the gut mucosal dynamics during sepsis. Haussner F, Chakraborty S, Halbgebauer R, Huber-Lang M. Challenge to the Intestinal Mucosa During Sepsis. Front Immunol. 2019;10:891. Published 2019 Apr 30. doi:10.3389/fimmu.2019.00891. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Sections of the Abstract, Introduction, and Conclusion are presented in the Podcast. Link to the full-text article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502990/

Definitionen und Gedankengänge zu Mucosa. Erfahre einiges über Mucosa in diesem kurzen Audio Vortrags-Podcast. Eine Ausgabe des Naturheilkunde Podcasts von und mit Sukadev Bretz, Yogalehrer bei Yoga Vidya. Anmerkung: Gesundheitliche Informationen in diesem Podcast sind nicht gedacht für Selbstdiagnose und Selbstbehandlung, sondern Gedankenanstöße aus dem Gebiet der Naturheilkunde. Bei eigener Erkrankung brauchst du Arzt oder … „Mucosa“ weiterlesen

The TWiV team reveals that recent mumps virus outbreaks in the US are due to waning vaccine efficacy, and an intranasally delivered small interfering RNA that controls West Nile infection in the brain. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 ASV 2018 Microbiology Student Symposium at UC Berkeley Support Viruses & Cells Gordon Conference Waning mumps vaccinein US (Sci Trans Med) siRNA controlof West Nile virus brain infection (Cell Host Microbe) Image credit Letters readon TWiV 488 Weekly Science Picks Kathy- Peak bloom and photographing cherry blossoms Dickson- Origins of vertebrate RNA viruses Alan- Rare footage of anglerfishin the deep ocean Vincent - NIH must reduce disparities in funding Listener Picks Mariann - Eden Project and Bellyvision Apparatus and the Like Amir- Winners of ICR Science Photography and Photography Contest Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Kurzer Vortrag mit einigen interessanten Einsichten zu Mucosa. Simple und Komplexe Überlegungen rund um Mucosa in einem besonderen Spontan-Audio Podcast. Diese Audio Podcastsendung ist eine Ausgabe des Naturheilkunde Podcast. Sie ist erstellt worden als Ausgangspunkt für einen Abschnitt im Yoga Wiki Naturheilkunde Lexikon von A-Z von Yoga Vidya. Sukadev, Leiter vom Yoga Vidya e.V., spricht hier über Mucosa vom Blickwinkel der Yoga Gesundheitslehre aus. Die Grundgedanken hinter Vedanta und damit der Yoga Philosophie sind Einheit, Mitgefühl, Mitmenschlichkeit, Liebe. Dabei gibt es viele Ebenen des Lebens. Yoga bezieht dabei auch Überlegungen zu Karma und Wiedergeburtslehre mit ein. Mucosa kommt aus Themengebieten wie Prävention, Heilmittel, Heilung, Medizin. Mit Klang und Musik kann man viel für Gesundheit, Heilung und Wohlbefinden tun. Wie das geht, erfährst du in einer Klangtherapie Ausbildung. Schreibe doch in die Kommentare, was dir dazu einfällt. Anmerkung: Gesundheitliche Informationen in diesem Podcast sind nicht gedacht für Selbstdiagnose und Selbstbehandlung, sondern Gedankenanstöße. Bei eigener Erkrankung brauchst du Arzt oder Heilpraktiker.

Kurzer Vortrag mit einigen interessanten Einsichten zu Mucosa. Simple und Komplexe Überlegungen rund um Mucosa in einem besonderen Spontan-Audio Podcast. Diese Audio Podcastsendung ist eine Ausgabe des Naturheilkunde Podcast. Sie ist erstellt worden als Ausgangspunkt für einen Abschnitt im Yoga Wiki Naturheilkunde Lexikon von A-Z von Yoga Vidya. Sukadev, Leiter vom Yoga Vidya e.V., spricht hier über Mucosa vom Blickwinkel der Yoga Gesundheitslehre aus. Die Grundgedanken hinter Vedanta und damit der Yoga Philosophie sind Einheit, Mitgefühl, Mitmenschlichkeit, Liebe. Dabei gibt es viele Ebenen des Lebens. Yoga bezieht dabei auch Überlegungen zu Karma und Wiedergeburtslehre mit ein. Mucosa kommt aus Themengebieten wie Prävention, Heilmittel, Heilung, Medizin. Mit Klang und Musik kann man viel für Gesundheit, Heilung und Wohlbefinden tun. Wie das geht, erfährst du in einer Klangtherapie Ausbildung. Schreibe doch in die Kommentare, was dir dazu einfällt. Anmerkung: Gesundheitliche Informationen in diesem Podcast sind nicht gedacht für Selbstdiagnose und Selbstbehandlung, sondern Gedankenanstöße. Bei eigener Erkrankung brauchst du Arzt oder Heilpraktiker.

Do you eat all the right foods but still struggle with health concerns? Do you feel like your health recovery is characterized by forward progress, followed by inevitable setbacks? Microbiologist Kiran Krishnan explains in detail what he believes is the “ground zero” of most health disorders: a weakened mucosa layer between the skin and the cellular lining. When the mucosa layer is defective, it becomes permeable, allowing toxins into our system that wreak havoc with our health. And some of these toxins are found even in the very food we eat! When our bodies are invaded in this way, it naturally elicits an inflammatory response. And inflammation, as we know, is associated with autoimmune diseases and chronic illnesses. From his studies, Kiran is convinced that many conditions that present quite differently—such as heart disease, arthritis, Hashimoto’s and Alzheimer’s, for example—stem from the root issue of a weak mucosa layer. In today’s episode, Kiran reveals not only the problem but the solution: how to strengthen our body’s defense systems by increasing microbial activity in the mucosa layer. This episode is a great resource for anyone who has an inflammatory condition or knows someone who is struggling with one!

Por fin salmones! después de incesantes esfuerzos logramos publicar un nuevo episodio! En esta nueva edición comentaremos una película que nos voló el cerebro y nos dejo dando jugo una semana, looooogicamente no nos quedamos solamente con la película y quisimos ir un poco mas allá, por lo cual terminamos cuestionándonos puras idioteces... como siempre! Esperamos lo disfruten y no olviden compartir, comentar, dar corazoncillos y bla bla bla!

In this podcast, Mairi McLean interviews Julián Panés and Azucena Salas, both from the Department of Gastroenterology, IDIBAPS, Hospital Clínic, CIBER-EHD in Barcelona, Spain. They disuse their recent article, looking at transcription in the intestinal mucosa of patients with ulcerative colitis.read the full article online: http://tinyurl.com/n3uy6d4

Neste vídeo descrevemos as lesões fundamentais da mucosa bucal.

Dr. Yukio Nagasaki discusses his manuscript, "An Orally Administered Redox Nanoparticle That Accumulates in the Colonic Mucosa and Reduces Colitis in Mice." To view the print version of this abstract go to http://bit.ly/Sv060D.

Colorectal Cancer

Die Schleimhaut der Cardiadrüsenregion des Schweinemagens ist sehr reich an Lymphfollikeln und damit als Teil des organisierten Schleimhaut-assoziierten lymphatischen Gewebes zu betrachten. Oberhalb der in der Mucosa gelegenen Follikel unterscheidet sich das Epithel (Follikel-assoziiertes-Epithel oder Dome-Epithel) von dem umgebenden Epithel, in dem es für die Antigenaufnahme spezialisierte M-Zellen enthält. Insbesondere in den serösen Drüsenabschnitten der Cardiadrüsenzone des Schweinemagens wurden im Follikel-assoziierten-Epithel Zellen beobachtet, die die morphologischen Kriterien von M-Zellen aufwiesen. Diese Zellen wurden auf das Vorkommen der Cytokeratine 4, 5/6, 7, 8, 14, 18 und 19 sowie der Intermediärfilamentproteine Vimentin und Desmin immunhistochemisch untersucht. Lediglich der Anti-Cytokeratin-7-Antikörper stellte selektiv die M-Zellen dar und kann daher als verlässlicher Marker für die M-Zellen in der Cardiadrüsenregion des Schweinemagens gelten.

In dieser Pilotstudie wurde die orale Gabe des Photosensitizers 5-ALA zur endoskopischen Dysplasiedetektion mittels Koloskopie und spektrometischen Messungen verifiziert und gleichzeitig eine Dysplasiefrequenzbestimmung an einem Patientengut mit langandauerender chronisch entzündlicher Darmerkrankung durchgeführt. Die orale Gabe des Photosensitizers führte zu einer ausreichenden Anreicherung des Fluorophores PPIX in der Mucosa; in dem bei uns untersuchten Patientengut war die Dysplasiefrequenz niedriger als nach den bisherigen Literaturdaten erwartet.

Background. Inflammatory alterations of the gastric mucosa are commonly caused by Helicobacter pylori (Hp) infection in patients with symptomatic gallstone disease. However, the additional pathogenetic role of an impaired gallbladder function leading to an increased alkaline duodenogastric reflux is controversially discussed. Aim:To investigate the relation of gallbladder function and Hp infection to gastric mucosa inflammation in patients with symptomatic gallstones prior to cholecystectomy. Patients: Seventy-three patients with symptomatic gallstones were studied by endoscopy and Hp testing. Methods: Gastritis classification was performed according to the updated Sydney System and gallbladder function was determined by total lipid concentration of gallbladder bile collected during mainly laparoscopic cholecystectomy. Results: Fifteen patients revealed no, 39 patients mild, and 19 moderate to marked gastritis. No significant differences for bile salts, phospholipids, cholesterol, or total lipids in gallbladder bile were found between these three groups of patients. However, while only 1 out of 54 (< 2%) patients with mild or no gastritis was found histologically positive for Hp, this infection could be detected in 14 (74%) out of 19 patients with moderate to marked gastritis. Conclusion: Moderate to marked gastric mucosa inflammation in gallstone patients is mainly caused by Hp infection, whereas gallbladder function is not related to the degree of gastritis. Thus, an increased alkaline duodenogastric reflux in gallstone patients seems to be of limited pathophysiological relevance. Copyright (c) 2006 S. Karger AG, Basel.

Background: In animal models ursodeoxycholic acid (UDCA) showed a chemoprotective effect against colon cancer. To explain this, a reduced proliferation of the colorectal mucosal proliferation was suggested. We, therefore, examined the influence of UDCA on the proliferation of normal colorectal mucosa in humans. Methods: Following endoscopic polypectomy, 20 patients with colorectal adenomas were randomized to receive either UDCA (750 mg/day, n = 10, group A) or placebo (n = 10, group B) for 6 months in a double-blinded way. Colorectal biopsies were sampled before and at the end of the medication by total colonoscopy. Colorectal mucosal proliferation was measured by FACScan analysis of propidium iodine labeling. Serum was sampled, and serum bile acids were analyzed by gas chromatography. Results: The proliferation rates at the end of the study were similar in both groups (median 15.4%; range 12.0-20.9 in group A; median 16.0%, 14.0-20.2 in group B, p = 0.41). Serum lithocholic acid levels at the end of the study were significantly higher in group A (1.3 mumol/l, 0.9-1.8) than in group B (0.7 mumol/l, 0-1.7, p < 0.02), whereas serum deoxycholic acid levels were similar in both groups. Conclusions: In this study, UDCA treatment for 6 months does not seem to induce changes in the proliferative behavior of the colorectal mucosa in patients with adenomas. It seems likely that a putative chemopreventive effect of UDCA in humans is not exerted by a reduction of the colorectal proliferation. Copyright (C) 2003 S. Karger AG, Basel.

Genotoxic effects of xenobiotics are a possible step in tumor initiation in the mucosa of the upper aerodigestive tract. Using the comet assay, detecting genotoxicity in human tissue has been restricted to single incubations in vitro, but in vivo most xenobiotics harm their target in a repetitive or chronic manner. Therefore, we propose a model, which provides repetitive incubations in human upper aerodigestive tract mucosa cultures. Samples of human inferior nasal turbinate mucosa (n = 25) were cultured according to a modified version of a technique originally described by Steinsvag. On day 1 fresh samples and on days 7, 9 and 11 organ cultures were incubated with N-nitrosodiethylamine (NDEA), sodium dichromate (Na2Cr2O7) and N'-methyl-N-nitro-N-nitrosoguanidine(MNNG). Mucosa samples and organ cultures, respectively, underwent a modified comet assay on days 1, 7 and 11. Genotoxicity could be shown for NDEA, Na2Cr2O7 and MNNG on days 1, 7 and 11. Duration of tissue culture and repetitive incubations did not significantly influence the results for NDEA. Nevertheless, Na2Cr2O7 and MNNG caused higher genotoxic effects on cultures subjected to the comet assay on day 11. This model may help to assess genotoxic hazards posed by environ mental pollutants that have a cumulative character in repetitive or chronic exposure in vivo. Copyright (C) 2001 S. Karger AG, Basel.

Neuropathological changes such as dystrophic neurites and the presence of abnormal tau protein in the olfactory system, including primary sensory cells and nerve fibres have previously been demonstrated in nasal mucosa tissue of patients with Alzheimer's disease (AD). These changes were detected in autopsy-derived material from histopathologically confirmed AD cases as well as in biopsy tissue from clinical severely ill AD patients. To investigate the potential usefulness for the early diagnosis of AD, we obtained biopsy tissue from olfactory mucosa from 5 clinically mild to moderate AD patients and stained for the presence of tau or beta-amyloid by immunocytochemistry using a panel of specific antibodies. No positive staining was found in any of the cases. For comparison, post-mortem olfactory tissue from AD patients with severe neuropathological changes (widespread neurofibrillary tangles and amyloid in the brain) was investigated, in these severe cases, tau immunoreactivity was found in fine nerve fibres in the lamina propria and in a few olfactory epithelial cells. These results are consistent with other reports showing that cytoskeletal changes and tau pathology in the olfactory epithelium are not primary (or specific) features of AD and may occur predominantly in late stages of the disease.

Fri, 1 Jan 1993 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7696/1/7696.pdf Holle, F.; Eisenmenger, Wolfgang; Siewert, R.; Ringel, R.; Riedel, J.; Stiegelmeier, M.; Holle, G. E.