Podcasts about new machine

WEEK IN GEEK: Andrew finishes up Cobra Kai, while D. Bethel finds a wonderful world to explore in Prince of Persia: The Lost Crown. BRAVE NEW CAPTAIN: D. Bethel rounds out the episode discussing his (mostly spoiler-free) thoughts of Captain America: Brave New World. On the whole, he liked it! TOPICS: (00:00) Intro - February's over, suddenly! (01:45) Andrew's WiG: The end of Cobra Kai (31:51) D. Bethel's WiG: Prince of Persia: The Lost Crown (45:20) Outro - D.'s thoughts of Captain America: Brave New World (mild spoilers) (52:21) Outtakes RELEVANT EPISODES: "Too Many Johnnies" (5 February 2021): Where our hosts have their first big sit-down conversation about Cobra Kai. "Full Frasier" (16 September 2022): Where Andrew discusses the fifth season of Cobra Kai. "New Machine, New Problems" (29 November 2024): Where Andrew shares his thoughts on the first part of Cobra Kai, season 6. INFO: Visit our website at forallintents.net and leave your thoughts as comments on the page for this episode. Join our Facebook page Social: Andrew - Mastodon, D. Bethel - Instagram Subscribe to our YouTube channel. FEATURED MUSIC: "Disco Medusae" by Kevin McLeod Link: https://incompetech.filmmusic.io/song/3652-disco-medusae "District Four" by Kevin McLeod Link: https://incompetech.filmmusic.io/song/3662-district-four Tracks are licensed under Creative Commons BY Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/

In this episode of the Levership Podcast, Chris Johnson and Matt Symes discuss the importance of building a sellable business, the various types of investments entrepreneurs can make, and the critical role of process improvement in maximizing returns. They emphasize the need for entrepreneurs to be intentional about their investments, particularly in processes and people, to create a sustainable business that serves their best life. The conversation also touches on preparing for business exit and the importance of normalizing financials to attract potential buyers.   Takeaways: Every aspiring entrepreneur should have a sellable business. Investing in process improvement is often overlooked. You can gain more from investing in processes than equipment. Investing in skills is crucial for growth. Normalizing your P&L can provide better insights into investments. Investing 20 cents on the dollar is essential for growth. You can have both a thriving business and a fulfilling life. Stop subjecting yourself to the tyranny of your business. Get intentional about the engine of your business. Building a business that serves your best life is possible.

Moving applications and data to a new machine isn't hard; it's just a fair amount of work.

01. Husky & Sydney Jo Jackson - Get Down (Birdee Extended Remix) 02. Kisch - Dive Deep (Extended Mix) 03. Ferreck Dawn x New Machine x Maverick Sabre - For The Weekend (Extended Mix) 04. Kevin McKay, NYLA - 2 On (Kevin McKay & Ludo Lacoste Extended VIP) 05. Milk & Sugar, James Hurr - I Love Music (Extended Mix) 06. Mercer - In My Arms (Extended Mix) 07. spacemen - High On The Feeling (Club Mix) 08. LewRaz, Yasmin Jane - Ownin' The Night (Extended Mix) 09. Yung Bae, axxa - Arrival (Extended Mix) 10. LP Giobbi - Carolyn (Original Mix) 11. Kira Divine feat. Marques Toliver & PNAU - Archaeology 12. JOEZI feat. Cali Bee - Give Me Tonight (Extended Mix) 13. Jersey - Ghost Of What Could Be (Original Mix) 14. Rommii - All Night On My Own (Extended)

For more information on John Antal and his work:+ https://madsciblog.tradoc.army.mil/497-the-dictators-dream-a-conversation-with-col-john-antal-usa-ret/+ https://www.youtube.com/watch?v=yoktqS7aWgo+ https://www.youtube.com/watch?v=rSKRH_UqSko Hosted on Acast. See acast.com/privacy for more information.

TOM HANKSGIVING: Andrew bought a new Mac, so he decides to play No Man's Sky while D. Bethel is Tom Hanksful for the delightful retro-stylings of the indie RPG, Beyond Galaxyland. GRIPESGIVING: With all the thanks out of the way, our hosts decide to complete the holiday by complaining about things. Andrew is mad at the new season of Cobra Kai while D. Bethel becomes irrationally furious with the new Wicked movie. TOPICS: (00:00) Intro: It's American Thanksgiving (03:34) Andrew buys a Mac Mini and plays No Man's Sky (17:59) D. Bethel loves Beyond Galaxyland (25:19) Outro: Gripesgiving #1 - Cobra Kai season 6 is interminable (28:27) Gripesgiving #2 - the 3-hour Wicked adaptation is only PART ONE?! (32:13) Outtakes RELEVANT EPISODES: "Chekhov's Honk" (22 January 2021): Where our hosts discuss The Karate Kid, The Karate Kid Part 2, and The Karate Kid Part 3, briefly. "Too Many Johnnies" (5 February 2021): Where our hosts dive into Cobra Kai. "Nomanski" (24 November 2023): Where our hosts talk about No Man's Sky. INFO: Subscribe to our YouTube channel. Visit our website at forallintents.net and leave your thoughts as comments on the page for this episode. Join our Facebook page Social: Andrew - Mastodon, D. Bethel - Instagram FEATURED MUSIC: "Disco Medusae" by Kevin McLeod Link: https://incompetech.filmmusic.io/song/3652-disco-medusae "District Four" by Kevin McLeod Link: https://incompetech.filmmusic.io/song/3662-district-four Tracks are licensed under Creative Commons BY Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/

The crew finds safety to figure out how to survive Night City. https://linktr.ee/clashofkrits   Support us on https://patreon.com/ClashofKrits to get access to our after show "Late Night Traffic" and More!

Réécoutez FG Chic Mix Urbana by David Penn du vendredi 4 octobre 2024 Tracklist : 1.cantos - Pocket Lint 2.Ferreck Dawn x New Machine x Maverick Sabre - For The Weekend - defected3.Paul Adam - desire - jackies music4.Urban Soul ft. Roland Clark - Alright (Mellow Man's Deeper Soul Mix) - 5.J Paul Getto - the vibe -6.Fedde Le Grand x Todd Terry ft. Rowetta - Baby Can You Reach - armada music7.David Penn & Rober Gaez - Deep Inside (Jay Vegas Remix) - urbana recordings8.Riordan - As The Beat Goes Onnn - 9.Milk & Sugar, James Hurr - i love music - toolroom10.Yero ft. 9 - After Hours - kryteria records11.kpd - Living My Dream - total freedom12.Calvin Harris & Rag'n'Bone Man - Giant (Riva Starr Tribe Vibe Extended Remix)

Urbana Radio Show By David Penn Chapter #659 01. Cantos - Pocket Lint 02. Ferreck Dawn x New Machine x Maverick Sabre - For The Weekend - Defected 03. Paul Adam - Desire - Jackies Music 04. Urban Soul Feat. Roland Clark - Alright (Mellow Man's Deeper Soul Mix) 05. J Paul Getto - The Vibe 06. Fedde Le Grand x Todd Terry Feat. Rowetta - Baby Can You Reach - Armada Music 07. David Penn & Rober Gaez - Deep Inside (Jay Vegas Remix) - Urbana Recordings 08. Riordan - As The Beat Goes Onnn 09. Milk & Sugar, James Hurr - I Love Music - Toolroom 10. Yero Feat. 9 - After Hours - Kryteria Records 11. KPD - Living My Dream - Total Freedom 12. Calvin Harris & Rag'n'Bone Man - Giant (Riva Starr Tribe Vibe Remix) Thanks to all the labels and artist for their music. All tracks selected and mixed by David Penn DJDAVIDPENN.COM FACEBOOK DJDAVIDPENN INSTAGRAM @DJDAVIDPENN INGENIUM BOKINGS EUROPA MUSIC MANAGEMENT Encoded by MUSICZONE PODCAST SERVICES.

The Martin Garrix Show #523Mix 11. Ferreck Dawn x New Machine x Maverick Sabre - For The Weekend [DEFECTED]2. ELYX - Free Your Mind [ACTUATION]3. Alterboy - What About Me [EXPERTS ONLY]4. Danny Rhys - Switch [TOOLROOM]5. Beyond Chicago - Need You feat. Janai [SOLOTOKO]6. Mason Flint - Power feat. Jasmine Knight [CLUB SWEAT]7. Martin Ikin - Everybody's Got To Learn Sometime [ULTRA]8. Ian Asher x Joe Stone - Never Leave You [MUSICAL FREEDOM]9. Vintage Culture - Pleasure Chasers (Joris Voorn Remix) [VINTAGE CULTURE]Mix 210. Meduza x Hayla - Another World [UMG]11. Tiësto, Swimming Paul - VHS RAVE [MUSICAL FREEDOM]12. Rain Radio, Cat Dealers - Eyes [SOUNDON]13. KLIPTO & GRX - Express Yourself [STMPD RCRDS]14. Tujamo x Toby Romeo x Lady Leshurr - Day In Day Out [CITY STARS RECORDS]15. Julian Jordan & Nouni - Never Stoppin' [STMPD RCRDS]16. Martin Garrix & Dyro - Latency [STMPD/SONY]17. Martin Garrix feat. Mike Yung - Dreamer (Nicky Romero Remix) [STMPD/SONY]A weekly selection of tracks that I love to listen to at home or play out at a party. New episodes uploaded weekly.

01. Husky & Sydney Jo Jackson - Get Down (Birdee Extended Remix) 02. Kisch - Dive Deep (Extended Mix) 03. Ferreck Dawn x New Machine x Maverick Sabre - For The Weekend (Extended Mix) 04. Kevin McKay, NYLA - 2 On (Kevin McKay & Ludo Lacoste Extended VIP) 05. Milk & Sugar, James Hurr - I Love Music (Extended Mix) 06. Mercer - In My Arms (Extended Mix) 07. Swedish House Mafia feat Alicia Keys - Finally (Extended Mix) 08. Steff Da Campo & Robbie Mendez - People (Extended Mix) 09. Mr. Belt & Wezol, Shift K3Y - Promises (Extended Mix) 10. Soul Heads - I'll Be Here (Extended Mix) 11. Cherry Tooth - Wanna Get High (Extended Mix) 12. Illyus & Barrientos - D.A.N.C.E (Extended Mix) 13. SHEE - Close My Eyes (Extended Mix) 14. Noise Cans - On Your Face (Extended Mix)

Urbana Radio Show By David Penn Chapter #656 1. David Penn - The Heat (James Mac Remix) - Club Sweat 2. Ferreck Dawn, New Machine, Maverick Sabre - For The Weekend - Defected 3. Junior Sanchez, Mike Dean - Weekend Vibes feat. Lee Wilson - D4 D4nce 4. Moon Boots - Hypnotizin' - Jackies Music 5. Soulsearcher - Can't Get Enough (Prunk Remix) - Defected 6. Alan Dixon - Nothing But Happiness - Glitterbox 7. Definite Grooves - Shake You Loose 8. Waze x Life On Planets - Bang 9. KPD - Money & Fame - Freakin909 10. Wh0 & Cassimm - Samba - Golden Recordings 11. Marco Lys & Ango Tamarin - Really In Love - Sbjkt 12. Robbie Rivera, Rivaz, Gambafreaks - Magalenha - D:Vision 13. Milk & Sugar, James Hurr - I Love Music - Toolroom Thanks to all the labels and artist for their music. All tracks selected and mixed by David Penn DJDAVIDPENN.COM FACEBOOK DJDAVIDPENN INSTAGRAM @DJDAVIDPENN INGENIUM BOKINGS EUROPA MUSIC MANAGEMENT Encoded by MUSICZONE PODCAST SERVICES.

Thank you to our Poly Podcast sponsor WL Plastics.

01. KC Lights - Turn Around 02. Gamuel Sori x Izzy Bizu - Messing With My Heart 03. Ferreck Dawn x New Machine x Maverick Sabre - For The Weekend 04. Hayden James - All In 05. Morgan Page, MorganJ & CloudNone - Water 06. Öwnboss x Dino Warriors - Can You Dig It 07. James Hype ft. Shamiya Battles - 7 Seconds 08. Max Styler & Oscar L - Addiction 09. Tita Lau & Chocolate Puma - I Wanna Be U 10. Crusy - Hey Girls, B-Boys 11. Tiësto - Drifting (KREAM Remix) 12. Riordan - As The Beat Goes Onnn 13. IDRIS & Shermanology - Shake Body 14. MOGUAI x Pizzata&Klein x Salvatore Mancuso - Free Your Mind 15. deadmau5 - Strobe (Layton Giordani Remix) 16. Benny Benassi ft. The Biz - Satisfaction (Zamna Soundsystem & Andro Remix) 17. Jax Jones x Joel Corry x Jason Derulo - Tonight (D.I.Y.A) [VIP Mix] 18. Mr. Belt & Wezol x Shift K3Y - Promises 19. Swedish House Mafia feat. Alicia Keys - Finally 20. Nathan Dawe x Joel Corry x SACHA - Higher

1. Ferreck Dawn x New Machine x Maverick Sabre - For The Weekend 2. Morgan Page, MorganJ & CloudNone - Water 3. Chico Rose - Chan Chan 4. Inner City x Anton Powers - Pennies From Heaven 5. (SR) Tita Lau, Chocolate Puma - I Wanna Be U 6. Croatia Squad - Get On The Floor 7. Tiësto, Swimming Paul - VHS RAVE 8. Lucas & Steve - Renegade Master 9. (AOW) Sander van Doorn - Take Yo' Praise 10. Tiësto, Lucas & Steve, SĀN-Z - ZENLESS 11. Mr. Belt & Wezol, Shift K3Y - Promises 12. Bingo Players, Disco Fries, Fatman Scoop - Our House 13. MOGUAI x Pizzata&Klein x Salvatore Mancuso - Free Your Mind 14. Lucas & Steve - Are You Ready 15. ROBBIE MENDEZ - HOME 16. Jonasu - Healing 17. HEDEGAARD, Martin Jensen, Victoria Nadine - Favorite Mistakes (HEDEGAARD VIP Mix) 18. Bassjackers, Yves V - Alibi

1. Ferreck Dawn x New Machine x Maverick Sabre - For The Weekend 2. Morgan Page, MorganJ & CloudNone - Water 3. Chico Rose - Chan Chan 4. Inner City x Anton Powers - Pennies From Heaven 5. (SR) Tita Lau, Chocolate Puma - I Wanna Be U 6. Croatia Squad - Get On The Floor 7. Tiësto, Swimming Paul - VHS RAVE 8. Lucas & Steve - Renegade Master 9. (AOW) Sander van Doorn - Take Yo' Praise 10. Tiësto, Lucas & Steve, SĀN-Z - ZENLESS 11. Mr. Belt & Wezol, Shift K3Y - Promises 12. Bingo Players, Disco Fries, Fatman Scoop - Our House 13. MOGUAI x Pizzata&Klein x Salvatore Mancuso - Free Your Mind 14. Lucas & Steve - Are You Ready 15. ROBBIE MENDEZ - HOME 16. Jonasu - Healing 17. HEDEGAARD, Martin Jensen, Victoria Nadine - Favorite Mistakes (HEDEGAARD VIP Mix) 18. Bassjackers, Yves V - Alibi

SPONSOR: www.mycomputerexorcist.com SPONSOR: www.mycomputerexorcist.com PRE-ORDER HERE: https://tentontradingco.com/collections/burn-my-eyes-30th-anniversary-us In the August 8th edition of CAP News, Chris dives into the highly anticipated release of *Diamonds in the Rough*. Set to drop on September 4th, 2024, this album is already generating buzz in the rock community. Chris breaks down the tracks, giving you an in-depth look at what to expect from this upcoming release. If you're a fan of rock music, you won't want to miss this review. Chris offers his honest take on the album's sound, lyrics, and overall impact. Tune in to find out if *Diamonds in the Rough* lives up to the hype. #CAPNews #DiamondsInTheRough #ChrisAkin #AlbumReview #RockMusic #NewRelease #September2024 #MusicReview #RockAlbum #UpcomingAlbums #MusicBuzz #AlbumBreakdown NOTE: Everything said here, and on every episode of all of our shows are 100% the opinions of the hosts. Nothing is stated as fact. Do your own research to see if their opinions are true or not. Please SUBSCRIBE, click the notification bell, leave a comment or a like, and share this episode!

Join the guys as they chat with Tay Whiteside and Walker Hooper of Lift Arc Studios. Tay, renowned for his expertise in salvage and fabrication, gained fame on the DIY Network's Salvage Dawgs, working with his father, Mike Whiteside, co-owner of Black Dog Salvage. At Lift Arc Studios, Tay showcases his artistic talent, creating remarkable metal sculptures and designs.   Also in this episode, ShopSabre announces the release of their new TC (Tube Cutter) machine, and they discuss the upcoming IWF 2024 event in August.   Weekly featured segments include "Internet is Broken," "Customer Questions," "Motivational Quote of the Week," and "Question for the Audience." Question for the Audience:If Money, space, or time was not a constraint to your decision for one thing - What would you do right now for your business or life & why?  Learn More and Follow Us: https://www.instagram.com/shopsabre https://www.facebook.com/shopsabre

Mon, 01 Apr 2024 20:30:00 GMT http://relay.fm/upgrade/506 http://relay.fm/upgrade/506 Legacy When? Legacy Now? 506 Jason Snell and Myke Hurley We often cite anonymous reports about Apple's future, but where do those reports come from? We discuss of the value and ethics of Apple rumor coverage. Also, we've seen the latest Vision Pro immersive video and have strong opinions. We often cite anonymous reports about Apple's future, but where do those reports come from? We discuss of the value and ethics of Apple rumor coverage. Also, we've seen the latest Vision Pro immersive video and have strong opinions. clean 6050 Subtitle: Let's Go Snell!We often cite anonymous reports about Apple's future, but where do those reports come from? We discuss of the value and ethics of Apple rumor coverage. Also, we've seen the latest Vision Pro immersive video and have strong opinions. This episode of Upgrade is sponsored by: Sanebox: Clean up your inbox in minutes. Sign up for a two-week free trial and a $25 credit. Ooni Pizza Ovens: Bring restaurant quality pizza to your home. Discount automatically applied at checkout. ExpressVPN: High-Speed, Secure & Anonymous VPN Service. Get an extra three months free. Links and Show Notes: Get Upgrade+. More content, no ads. Check out Upgrade merch! Submit Feedback The Amazing Spider-Man (2018 - 2022) | Comic Series | Marvel All of the Marvels: A Journey to the Ends of the Biggest Story Ever Told – Wolk, Douglas: Amazon Here's What Apple Retail's New Machine to Update iPhones in the Box Looks Like - MacRumors WWDC24 - Apple Developer Apple Developer - YouTube What Will the European Commission Do With the Money It Receives From DMA Related Fines? – Perplexity When Is the New iPad Pro, iPad Air Coming Out? Apple Plans Early May Launch - Bloomberg Apple Sues Former Employee for Leaking iPhone's Journal App and More - MacRumors Michael Gartenberg's question on Leaks MacWEEK - Wikipedia MacRumors Buyer's Guide Apple's Immersive Video problem – Six Colors MLS on Vision Pro, The Vision Pro's Missing Content, The Vision Pro's DRI – Stratechery by Ben Thompson PSA: The MLB app doesn't work on the Mac anymore – Six Colors MLB for visionOS strikes out on Opening Day – Six Colors The Talk Show ✪: Ep. 397, With Jason Snell

Mon, 01 Apr 2024 20:30:00 GMT http://relay.fm/upgrade/506 http://relay.fm/upgrade/506 Jason Snell and Myke Hurley We often cite anonymous reports about Apple's future, but where do those reports come from? We discuss of the value and ethics of Apple rumor coverage. Also, we've seen the latest Vision Pro immersive video and have strong opinions. We often cite anonymous reports about Apple's future, but where do those reports come from? We discuss of the value and ethics of Apple rumor coverage. Also, we've seen the latest Vision Pro immersive video and have strong opinions. clean 6050 Subtitle: Let's Go Snell!We often cite anonymous reports about Apple's future, but where do those reports come from? We discuss of the value and ethics of Apple rumor coverage. Also, we've seen the latest Vision Pro immersive video and have strong opinions. This episode of Upgrade is sponsored by: Sanebox: Clean up your inbox in minutes. Sign up for a two-week free trial and a $25 credit. Ooni Pizza Ovens: Bring restaurant quality pizza to your home. Discount automatically applied at checkout. ExpressVPN: High-Speed, Secure & Anonymous VPN Service. Get an extra three months free. Links and Show Notes: Get Upgrade+. More content, no ads. Check out Upgrade merch! Submit Feedback The Amazing Spider-Man (2018 - 2022) | Comic Series | Marvel All of the Marvels: A Journey to the Ends of the Biggest Story Ever Told – Wolk, Douglas: Amazon Here's What Apple Retail's New Machine to Update iPhones in the Box Looks Like - MacRumors WWDC24 - Apple Developer Apple Developer - YouTube What Will the European Commission Do With the Money It Receives From DMA Related Fines? – Perplexity When Is the New iPad Pro, iPad Air Coming Out? Apple Plans Early May Launch - Bloomberg Apple Sues Former Employee for Leaking iPhone's Journal App and More - MacRumors Michael Gartenberg's question on Leaks MacWEEK - Wikipedia MacRumors Buyer's Guide Apple's Immersive Video problem – Six Colors MLS on Vision Pro, The Vision Pro's Missing Content, The Vision Pro's DRI – Stratechery by Ben Thompson PSA: The MLB app doesn't work on the Mac anymore – Six Colors MLB for visionOS strikes out on Opening Day – Six Colors The Talk Show ✪: Ep. 397, With Jason Snell

Drs. Shaalan Beg and Travis Osterman discuss a machine learning model, recently featured in JCO Clinical Cancer Informatics, that uses electronic health record data to accurately predict the effectiveness and toxicity of treatment with immune checkpoint inhibitors. The new AI model can be used to provide a personalized risk-benefit profile, inform therapeutic decision-making, and improve clinical trial cohort selection.   TRANSCRIPT Dr. Shaalan Beg: Hello, and welcome to the ASCO Daily News Podcast. I'm Dr. Shaalan Beg, your guest host for today. I am an adjunct associate professor at UT Southwestern's Simmons Comprehensive Cancer Center.  Cancer immunotherapy has transformed the treatment landscape by providing new and effective treatment options for many solid and hematologic malignancies. But while many patients experience a remarkable response to immune checkpoint inhibitors, other patients can suffer life-threatening immune checkpoint toxicities. Today, we will be discussing a machine learning solution that can assess a patient's immune checkpoint inhibitor risk-benefit profile based primarily on routinely collected structured electronic health record data. This novel AI solution was recently featured in JCO Clinical Cancer Informatics, and I am delighted to welcome one of the report's authors, Dr. Travis Osterman. He is an associate vice president for research informatics and associate professor in the Department of Biomedical Informatics and the Division of Hematology Oncology at Vanderbilt University Medical Center in Nashville, Tennessee. Dr. Osterman also serves as the director of cancer clinical informatics at the Vanderbilt Ingram Cancer Center.  Our full disclosures are available in the transcript of this episode, and disclosures related to all episodes of the podcast are available at asco.org/DNpod.  Dr. Osterman, it's great to have you on the podcast today.   Dr. Travis Osterman: Thanks, Shaalan. It's great to be here. Thank you for the invitation.   Dr. Shaalan Beg: Congratulations on your recently published article in the JCO CCI titled "Prediction of Effectiveness and Toxicities of Immune Checkpoint Inhibitors Using Real World Patient Data." Why did you decide to address this specific problem?   Dr. Travis Osterman: I am a practicing medical oncologist at Vanderbilt, I specialize in thoracic malignancies. Immunotherapy has been a significant part of my practice from the beginning. And I think for all of us, we have patients in our practices that are tremendous responders. I have stories of my patients, a few of which, at least, are able to get years of benefit even after stopping therapy, and potentially some even stage 4 patients that are amazingly seemingly cured after their treatments. But I also have patients that experience severe toxicities, some of those are life-threatening or life ending, but many of those carry morbidity. In my population, I see a lot of pneumonitis, and that really alters patients' quality of life. And the biggest conversation I have with patients is: “How do I know which of these outcomes I'm going to have, if I'm going to get benefits from these therapies or am I going to get one of these side effects or toxicities?” And we set out to try to answer that question with data.   Dr. Shaalan Beg: When electronic medical records started to make their way into the clinic, I remember all of us thinking about the wonderful applications where we could use the data to help guide the clinical care, assign the right treatment for the right patient at the right time, and learn from other patients' experiences to improve the care of the person who's in front of us. And my personal opinion is that we haven't realized our electronic medical records' potential to that extent. And efforts like the one you published in JCO CCI is the culmination of one of the efforts, and I can only imagine how much time and effort it must have taken to develop that and we're hoping is the first of many more to come. For our listeners, can you talk us through the steps required to develop such a tool, and why now is the right time, and why we're starting to see these evolve?   Dr. Travis Osterman: This project would not have been possible 20 years ago. It relies on having what we would call structured data available for our patients that are receiving cancer care, so that's vital signs, laboratory values, and diagnoses, all of the things that we routinely collect in the electronic health record. So that is step 1. This project required that those systems be not just in place at academic centers but be widely available because our goal is to set up systems that will be able to transform cancer care, not just at academic institutions, but for the entire practice of oncology.  The second piece is you need enough data to be able to train these models. And so, we needed to be practicing with checkpoint inhibitors long enough to see patients that had toxicities, to see patients that had benefit, and then to jump into the data science of actually trying to learn from them. And so this really was the culmination of systems put in place by a lot of people before us and then really the right time [when] we started to have now enough data to really start to learn from.   Dr. Shaalan Beg: The publication discusses the steps of how you validated your tool. Talk me through how you see this being applied to the point of care for the next time you are about to start an immune checkpoint inhibitor for your lung cancer patient?   Dr. Travis Osterman: I think there are two different primary lanes that these types of models can be applied. In the drug development space, I think many of us are familiar that many assets, many drugs that are in the development pipeline are halted because of adverse events in toxicity profiles, but we also realize that not everyone gets those toxicities. And so we envision a future where before a drug that's in the drug development pipeline is taken out of the development pipeline, potentially, you could screen patients that are at lowest risks of actually having side effects from that immunotherapy and only screen those patients into the trial and that would potentially make more drugs available to more patients going forward. So I think that that's 1 lane.  I think the other lane in clinical practice is, let's say that I'm treating a patient who we determine has an increased risk for colitis. Instead of only seeing that patient back in 3 weeks, potentially, now, what if I had one of our nurse navigators, call the patient at weekly check-ins between visits to check in and see whether or not they were having any episodes of diarrhea and trying to intervene earlier. That might allow us to keep patients both out of the hospital, out of the emergency department to treat their symptoms more quickly to decrease the severity of their toxicity and keep them on treatments, especially if they're receiving benefit from it. So, I think there's an opportunity to improve both drug development and making more drugs available to patients and then also to identify patients that are at risk for toxicity, and then to do interventions to help mitigate those risks. Really, the idea of precision risk mitigation.   Dr. Shaalan Beg: One of the problems with electronic medical record-based tools in the past has been that they don't evolve with time. We develop it, we set it, we deploy it, and it almost feels, to the users at least, that it stops evolving after that. With novel therapeutic agents coming into the clinic, we're seeing new ADCs, new novel checkpoint inhibitors entering the market. How do you envision tools such as yours to be refreshed so they can stay relevant with the modern armamentarium of medications which are being used?   Dr. Travis Osterman: So, if you ask any data scientist, the most requested item they will ask for is more data. And so, this initial set of models that we've described in this publication were trained exclusively on a single institution's data at Vanderbilt University Medical Center as we continue both to see more patients here, and then ideally look forward to collaborations with other centers. We expect that these models will continue to be refined and that the performance will improve as we increase the amount of training data, and we hope that that will do 2 things. One, it will counteract the kind of model drift that you described. But then two, it will allow us to ask some more specific questions that honestly, we weren't really powered to answer in our study here. For instance, we didn't look at cardiac toxicity, which is a concern if you're giving a CTLA-4 along with a PD-1 or PD-L1 inhibitor more so than single agent immunotherapy. We just don't have enough events to be able to train models on that. But with future collaborations, that would be a question we would love to tackle as well.  One of the things that's interesting about the implementation of these models is that we found many of the features that I would have expected to find as a practicing oncologist. For instance, when we're trying to predict the toxicity of pneumonitis inflammation of the lung, I as an oncologist would think that many of my patients that have COPD or interstitial lung disease at baseline seem to be at a higher risk. And so that's one of the features that I was looking to come out in the model. And that's exactly what we found. That was one of the contributing features that helps us predict a higher risk of pneumonitis. But what's interesting is that's certainly not the only feature; there end up being about a dozen features that are in that space that help predict that toxicity.   Similarly, for colitis, we found that the combination of receiving a CTLA-4 inhibitor in addition to a PD-1 or PD-L1 inhibitor, that combination together, which would increase risk for colitis, which is well-documented in our literature. So these models are not entirely black boxes. We've published the top features of these models that contribute to our predictions. And I think clinically the challenge for me has always been if I have a patient who has COPD, but it's pretty well-controlled and their O2 sat is normal, how does that patient's risk bring pneumonitis compared to someone who has poorly controlled COPD with low O2 sat at baseline, etc.? And so these models are really designed to help tease out some of those nuances.   Dr. Shaalan Beg: There are so many wonderful applications to use preexisting data that can improve the lives of our patients and frankly that can improve the work experience for clinicians. They can be used for risk stratification using these preexisting data. Can you talk a little bit about what are the barriers that people face or that your team faced in developing these tools, and what has changed or what's expected to change in the coming years to allow people to continue developing tools such as what was described?   Dr. Travis Osterman: I think it's important to realize that we are not unique in addressing this problem. This is a problem that I think has been a focal point of our cancer informatics community for the better part of the last, probably, decade. I think one of the things that distinguishes the work that we've done here is really this idea of clinical utility. And what I mean is we focused on data that would be collected at any routine oncology visit in the U.S., and I would argue worldwide, to use as features in our model. So, we're not running complex genetic testing that may or may not be paid for. We're not asking for new laboratory values to be sent or for extensive questionnaires that aren't already in clinical practice. We're using pieces that are already being connected into the pipeline of oncology practices, and I think that's one of the differentiators of this project versus many others in this space.  Right now, these are only EHR data. We have a part of our project that's looking at imaging data and whether that adds value. But one of the pieces that I always advocate for, if we're going to ask practices for instance to upload these imaging files or to send a CD to a central location to improve the outcome, that's harder to work into an oncologist workflow than if all the data are already there in the health record and you can click a button and calculate this person's risk profile. And so, we've really tried to be pragmatic about our approach as we've entered this realm and that's been a real focus of our team.   Dr. Shaalan Beg: Many of the listeners of today's podcast are busy clinicians, and you talked about how the idea for this project came from the problem you witnessed in your clinic. How can clinicians continue to be involved in such initiatives or drive these initiatives at their own institutions, in office situations where they may not have the resources that your team has? Can you speak to national efforts or collaborations in this regard?   Dr. Travis Osterman: Yeah. So, first of all, I would invite really anyone to reach out to our team, if they're in a position where they'll be interested in validating our models at their local institutions. We would be happy to work with them to provide the models to see how they perform on their data sets. I think that that's an important part of the academic review and informatics is to see how these models translate into other health care settings. And we also are interested to make sure that what I said in the prior discussion is correct, that we're only incorporating things that other institutions already have. So I think that that's certainly one.  The second is a part of a large National Cancer Data standard project called mCODE, the Minimal Common Oncology Data Elements, I chair that executive committee. And one of the pieces of that is trying to find a way to make all of these kinds of structured data interoperable between health records. And so I would just encourage all of my colleagues to always advocate for interoperability and, when there's an option, to store data in a way that makes that data more easily shared in the same formats between institutions. I think that that will pay many dividends for our field going forward. And I just want to plug all the team at mCODE for their work in this and maybe there'll be an integration and connection between mCODE and our project in the future.   Dr. Shaalan Beg: Thank you very much Dr. Osterman for sharing your insights with us today on the ASCO Daily News Podcast.   Dr. Travis Osterman: Thanks, Shaalan. Have a great day.   Dr. Shaalan Beg: And thank you to all our listeners for your time today. You'll find a link to Dr. Osterman's article in the transcript of this episode. And if you value the insights that you hear on the ASCO Daily News Podcast, please take a moment to rate, review, and subscribe wherever you get your podcast.   Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity or therapy should not be construed as an ASCO endorsement.   Find out more about today's speakers: Dr. Shaalan Beg @ShaalanBeg Dr. Travis Osterman @TravisOsterman   Follow ASCO on social media:  @ASCO on Twitter  ASCO on Facebook  ASCO on LinkedIn    Disclosures: Dr. Shaalan Beg: Employment: Science 37 Consulting or Advisory Role: Ipsen, Array BioPharma, AstraZeneca/MedImmune, Cancer Commons, Legend Biotech, Foundation Medicine Research Funding (Inst.): Bristol-Myers Squibb, AstraZeneca/MedImmune, Merck Serono, Five Prime Therapeutics, MedImmune, Genentech, Immunesensor, Tolero Pharmaceuticals   Dr. Travis Osterman: Stock and Other Ownership Interests: Faculty Coaching Honoraria: Amazon Web Services Consulting or Advisory Role: eHealth, AstraZeneca, Outcomes Insights, Biodesix, MD Outlook, GenomOncology, Cota Healthcare, Flagship Biosciences, Microsoft, Dedham Group, Oncollege Research Funding: GE Healthcare, Microsoft, IBM Watson Health Travel, Accommodations, Expenses: GE Healthcare, Amazon Web Services

Antidepressants changed my life. I have OCD and antidepressants did what nearly a decade of therapy, meditation, and supplements couldn't: they allowed me to live my life without being in a 24/7 spiral. (Bonus: they actually made therapy and meditation far more helpful once they started to work.) I think antidepressants are seriously misunderstood. Yes, they blunt negative emotions. But they also operate on personality and sense of self: they can make you bolder, less sensitive to failure, and less risk-averse. In short: they are a technology that changes how we see ourselves and the world. That's why I invited Dr. Peter D. Kramer on my show. Dr. Kramer is a psychiatrist and the author of eight books, including Listening to Prozac, which is an international bestseller. He has practiced psychiatry and taught psychotherapy at Brown University for nearly four decades. Listening To Prozac is one of my favorite books, and it documents Dr. Kramer's experiences as a psychiatrist seeing how antidepressants like Prozac changed his patients' sense of self and personality. Now, you might be wondering why have him on a show about ChatGPT? Well, technology can change who we are even if it comes as a software product rather than a pill. It's undoubtedly true that as generations of humans learn to live with AI, it will change what it means to be human—and how we see ourselves and the world. I think that can be a good thing, but it could also be scary. I wanted to talk to Dr. Kramer about his book, and see if we could apply some of his insights in Prozac to ChatGPT. It was an incredible conversation, and I was honored to talk to him. Want even more? Sign up for Every to unlock our ultimate guide to prompting ChatGPT. It's usually only for paying subscribers, but you can get it here for free. To hear more from Dan Shipper: Subscribe to Every: https://every.to/subscribe  Follow him on X: https://twitter.com/danshipper  To learn more about the topics in this episode: Listening to Prozac by Peter D. Kramer ChatGPT and the Future of the Human Mind by Dan Shipper SSRIs by Scott Alexander Timestamps: Introduction: 00:50 How technology changes the way we see ourselves and the world: 08:24 Antidepressants and their impact on our personality and sense of self: 21:25 How the availability of a technological solution prompts us to see the problem everywhere: 26:35 Technology alters the categories we have divided the world into: 34:06 How I use ChatGPT in my writing process: 40:05 Experimenting with ChatGPT to get relationship advice: 45:41 Prompting ChatGPT to be more specific: 51:16 Clearly indicate the tone you want ChatGPT to take: 55:11 Dr. Peter D. Kramer's final thoughts on ChatGPT as a therapist: 1:02:27 Links to resources mentioned in the episode: Dr. Peter D. Kramer: https://twitter.com/PeterDKramer  ChatGPT and the Future of the Human  Mind by Dan Shipper: https://every.to/chain-of-thought/chatgpt-and-the-future-of-the-human-mind  Listening to Prozac  by Dr. Kramer: https://www.amazon.com/Listening-Prozac-Landmark-Antidepressants-Remaking/dp/0140266712  Should You Leave? by Dr. Kramer: https://www.amazon.com/Should-You-Leave-Psychiatrist-Autonomy/dp/0140272798  Against Depression by Dr. Kramer: https://www.amazon.com/Against-Depression-Peter-D-Kramer/dp/0143036963  Ordinarily Well by Dr. Kramer: https://www.amazon.com/Ordinarily-Well-Antidepressants-Peter-Kramer/dp/0374536961  Pierre Menard, Author of the Quixote by Jorge Luis Borges: https://raley.english.ucsb.edu/wp-content/Engl10/Pierre-Menard.pdf  The Soul of A New Machine by Tracy Kidder: https://www.amazon.com/Soul-New-Machine-Tracy-Kidder/dp/0316491977  Making Hay by Verlyn Klinkenborg: https://www.amazon.com/Making-Hay-Verlyn-Klinkenborg/dp/0941130185  Oranges by John McPhee: https://www.amazon.com/Oranges-John-McPhee/dp/0374512973 

Transferring installed software to a new machine isn't as easy as we might like. I'll list the options.

Welcome to a new episode of Dug By Us.Chris: Fanny Lumsden - You'll Be Fine, listen, get it, watch it here Cassie: CLAUDE - Paul Rudd, get it hereConnect with Dug By Us on Instagram hereFollow our Songs Only Playlist on Spotify hereDug By Us is made on the lands of the Wurundjeri people of the Kullin Nation. we pay our respects to elders past, present and emerging.Sovereignty was never ceded. Alway was, always will be Aboriginal Land. Hosted on Acast. See acast.com/privacy for more information.

Welcome to the first ever episode of the Liquid Weekly Podcast! A podcast all about Shopify Development. In this episode, Karl and Taylor introduce themselves and talk about how they got started in coding and eventually Shopify. Karl also shares more about the vision for Liquid Weekly and the purpose of the podcast. Taylor explains how he went from being a social worker to a self-taught full-time freelancer and Shopify Expert customizing Shopify themes. Talking about a failed dropshipping store and freelancing "diaper money" to full-time work and building up a business. Karl talks about how he started with computers from a very young age and being inspired by the web and what all could be done. This led to starting his education in computer programming but Karl jumped into the freelancing and web development world quickly while still getting his education. Karl went on to work through various freelancing and full-time engineering positions before moving into consulting and specializing in Shopify. Both Karl and Taylor talk about the benefit of niching down and how focusing on Shopify has helped their careers. // Resources and Links // *some links are affiliate links and it's possible that by purchasing through the link we may earn a small commission Shopify Theme Customization with Liquid by Ivan Djordjevic (book): https://www.amazon.com/Shopify-Theme-Customization-Liquid-state/dp/1801813965 (affiliate link: https://amzn.to/3Oc6aeo) Shopify Dev Changelog Scheduled: https://shopify.dev/changelog/scheduled Changes to Asset URLs: https://changelog.shopify.com/posts/changes-to-asset-urls Shopify Dev Changelog, merchant asset URLs: https://shopify.dev/changelog/changes-to-merchant-asset-urls Shopify Liquid File URL Filter: https://shopify.dev/docs/api/liquid/filters/file_url The Soul of a New Machine by Tracy Kidder (book): https://www.amazon.com/Soul-New-Machine-Tracy-Kidder/dp/0316491977 (affiliate link: https://amzn.to/3YhUqMi)

Nick, Rakeman, Donkey and Randy are in the studio this week. The crew discusses what they look at when purchasing a new ATV.

In this episode:Mike and Ed continue their discussions on what the original Avengers are doing in their post-Avengers lives. For instance, Thor now seems to be working for the American military in Vietnam. Was he drafted? Or did he consider deserting to move back to Asgard? Will super-powered individuals become the next weapon of war? Will heroes sell their services to the highest bidding country? Is there a way to stop the escalation, or is this just the new way of the world?Behind the issue:Stan had Thor appear in Vietnam, but never had him coordinating with the US military. Comic books in the 1940s were practically US-propaganda, and the heroes were expected to be fighting against Hitler. But in the 1960s, the writers mostly kept the heroes out of real-world conflicts. It wasn't until the modern era that writers considered the possibility of heroes fighting in Vietnam.In this issue:Thor is spotted in Vietnam and shot by a hunter. The hunter then comes across an ancient temple and, through the machinations of Loki, the hunger takes over the Destroyer armour with his mind. The hunter pilots the Destroyer in a fight with Thor. Meanwhile on Asgard, Loki is imprisoned.This episode takes place:While people are still adjusting to “Cap's Kooky Quartet” - and missing their “old” Avengers.Assumed before the next episode:People are wondering what Thor was doing in Southeast Asia.Full transcript:Edward: All right, Mike. Continuing our, where are they now? Series. We now know where Thor has been for the last couple of months.Michael: Yeah. He's decided to take his retirement to Vietnam.Edward: Vietnam, you'd think with his hair like that, he would've been a conscientious objector, but no Siri, don't stereotype Thor. He is right there with the military. Right in the thick of things.Michael: All kidding aside, it's pretty wild that this man, or this being Thor, who's associated with, the American military and the military industrial complex has gone to Vietnam, clearly on behalf of the Americans, and intervened in international affairs. Clearly as an agent of America, or at least on America's interest. Yeah, for sure. Doesn't that make it a little more complicated over there? Is that what we wanna,Edward: I think it makes it less complicated. ANCO was clear before that the Avengers were an American superhero organization that had American interest at heart. Their leader was Captain America. It's pretty clear that they were into America and hey, they were supported and run by, stark Corp, who are like basically a big American company. They're an American team now, Thor leaves the American team that he leaves the Avengers.What does he do next? He doesn't go back up to Asgard. He goes and works for American interests in a non Avengers way.Michael: It seems a little, isn't it? I don't know. I find it uncomfortable that we would entrust, international diplomacy to, well, it's costume adventures.Edward: Well, it's not diplomacy. He's not negotiating peace treaties. He's swinging his hammer and like on a hitting North Vietcong.Michael: But this. But there's consequences to that though. Like aren't you worried that that's gonna lead to say, other Superpowered beings that might be drafted in by the Vietcong to fight American soldiers overseas in,Edward: do the Viet Cong have a superhero?Michael: Not yet. Well, there you go. Not yet, but there you go. But you don't think the Chinese might have an interest in this. Have a say in it.Edward: That's, that, that is true. We know the Chinese do have their own superheroes. Radioactive man. Radioactive man. So, you're saying it's an escalation of the conflict. And maybe this means China sends in radioactive man, but China is not like US is directly involved in that war. China is only indirectly involved, right? They have plausible deniability. If they send in radioactive man, there goes their plausible deniability.Michael: Well first of all, there hasn't been a military briefing or any kind of official report in that Thor is going there on the direction or in service of the United States. So, I think the United States is trying to do this if they're doing it under some kind of plausible deniability scenario, and China could do the same thing, like we don't control radioactive man.He's just a guy who believes in our values and that's why he is fighting. He's just showing up and fighting. Showing up and fighting, and that's why he is fighting the Americans in Vietnam.Edward: But there's no Chinese soldiers in the vie, they're supplying them with weapons and stuff, but they're not supplying them with people I don't think. Here's the question. That's an ex escalation though. Here's, here's the question. Was Thor just drafted? Maybe he was just part of the draft.Michael: I don't know. Well, he might have been, but thatEdward: his number came up and he off he went.Michael: He, had to go.Edward: He had to go. He had no choice.Michael: He was gonna fly away to Asgard. But No, but I'm still thinking about deescalation,Edward: other deserters run to. Canada, but not Thor. He heads to a whole intervention, flies to another, another realm, a mystical realm. Yeah. But he knew he wanted to come back to America. So he knew that if he abandoned us, we weren't gonna let him back in.Michael: So if I look at it and you look at it, the Vietnamese will probably look at it and the Chinese look at it that America has sent a superpowered individual to fight a battle on their behalf.Clearly that what has happened. So I would think that the natural response would be that the Vietnamese through some kind of connection have one of their own. And then now we have, are we having our superpowered heroes and villains or people fighting each other?Not just fighting each other, but fighting regular powered humans? Well, I think so. It's like if they think if they we're getting to a different era, I guess,Edward: but I think, these people have powers and they're outta capabilities. It's almost like, if we had a really good tank, let's not use it because the other guys might bring in a big tank.We have airplanes, let's not use airplanes cuz the other guys might have airplanes. We have an advantage over the Vietnamese right now because we have superheroes and they don't. Not using them, I think would be irresponsible. Americans would die if not for Thor. Thor is probably saving American lives right as we speak.Michael: Yeah, but Ed, right now, America could use nuclear bombs in Vietnam, but they're not gonna, they're not, not,Edward: we're not gonna use nuclear. But nuclear bombs have all sorts of like side effects that a lightning bolt from Thor, there's no radiation when he fires a lightning bolt and blows up a, nothing like a depot.Michael: Lightning, basically Radiation?Edward: No, it's, no, it's not radiation any more than the light is radiation.Michael: Not basically, but I'm sure there is radiation that comes off of, there's certainly the light part of it and that part of the spectrum.Edward: Yeah, but there's no radiation. It's not radioactive.When you get hit by lightning, you're not gonna cause cancer when you get hit by lightning. Now you may die when you get hit by lightning, but it's not gonna cause future cancers.Michael: But my point is that America could use nuclear weapons, but they don't because they don't, they know that that could lead to an escalation.So isn't sending a superhero in kind of similar thing?Edward: It's more than an escalation response. Yes. Yes. I think it's a big, we should not be using nuclear weapons. We don't want to go down that route. But a superhero is not a nuclear weapon. We use superheroes all the time. We use superheroes all the time for, we use superheroes when stilt man attacks New York City, we're not gonna drop a nuclear weapon on Stilt Man.Michael: No, but the difference is that there's a difference between fighting crime in the city and then going to another nation. To affect foreign policy through, excessive force similar to a nuclear bomb sending, I think a superpower person's gonna do the, achieve the same result.Edward: I feel that the Vietnam War is already at the excessive force stage. We're, we're not like, this is devastating. Let's have a, let's have a very stern conversation with them. Like there's people shooting at each other there there's war happening, there's helicopters and bombs and Tanks and so why shouldn't Thor be involved to, to help put an end to this thingMichael: But this is a devastating next step. I mean the fact that you say it's irresponsible for them not to use Thor means, cuz you know, he's gonna be particularly effective. Much like individuals are bombed. Yeah, I think so. Why don't, so doesn't this lead to other nations around the world saying like, well better get some more superpowered individuals and then it gets into a bidding war. We've already talked about how the Avengers used to be a bunch of strangers who kind of got together very powerful and they've basically disbanded. And now it's like a bunch of former villains, you know, who are now with Captain America, which is pretty bizarre to say that they,Edward: Maybe this makes even more sense now, right? If you have these people like. Quicksilver and the witch and the Hawkeye. And your choice is, hey, bring them onto the Avengers and make them part of our team. Or let them become free agents and join the Soviets. Maybe that makes the most sense that we brought them onto the team.Michael: Maybe, but are we not getting to an era? Mercenaries, the superheros turning to mercenaries. What keeps them loyal to one particular ideology over another? I don't know, like is the American structure better than, the American democracy better than other forms of political philosophies in governments? You talk to every American I've ever spoken with, they'd say, no, it's the best. But other nations have different approaches to, policy, politics, and governments and structures and say, no.Edward: We had this in World War ii, right? We were the most attractive there was a lot of scientists that said, oh, you know what? Let's help the US build the atomic bomb because we want them to have it not the other guys. And those, a lot of those scientists came from Germany, but they said, no. Mm-hmm We wanna work for America. Or they came from Soviet Russia with, no, we wanna work for America because we think that you guys. We are freedom loving and as problematic as the US has been over the years doing many, many things they probably shouldn't have.The alternatives seem to be a lot worse and superhero superheros are lining up behind that. They're realizing that better to work for America than work for the other guysMichael: for now. But what happens if , For instance, let's just pick our neighbor to the north, let's say in Canada. They just decide to say up the ante to get a superpowered individual that could lead to say, battling other nations. So they became more war monering because you know that America's, you know, mightEdward: Canada becomes the, the war Moner. Yes, the war moner. You can call me either their hockey sticks, you can call me captain. Boring. That'sMichael: not boring captain, but they go. But my point is that, is that any nation.If they for the right price could get a superpowered individual who might think, you know, I like their philosophy too and we know that American might has led to American, financial benefits as well, right? I mean they, people don't just think America's great and that's why America does so well financially.No, we're great because they make great movies. Make great movies and actually use their money and their might to influence world markets. And so who's to say that the long plan might be like, say, great Britain might just start building up their SUPERPOWERED individuals so that they can basically go and effect world affairs through the superheroes.That that would then lead to increasing their financial, um, that's, that'sEdward: okay with that. Take America with that. They're not gonna take out Amer London is gay. This is not the American Revolution. America. If Britain, Britain, Britain is our ally, if Britain is more successful, now's good. That's good.Michael: Thor just, Thor just got sent into Vietnam. I'm just saying that we're on the prey, I think of changing how, international affairs are structured and how disputes are resolved if we're getting into sending superheroes to other nations. To fight on a base, on an ideological basis against other nationsEdward: superheroes, adjust the next technology.I feel like Mike, you'd be against using the airplane in World War I. You'd be like, no. If we use the airplane, maybe they'll use the airplane. Oh no. That'd be terrible. That'll be planes flying everywhere. That'll be the end of world order. No, as long as we make more airplanes than they do, we'll be fine.And we're making more superheroes than everybody else in the world combined.Michael: But I think one of the main things that came out, the difference between World War Well, sorry. World War I, what was a game changer was the machine gun, right? The mechanized instruments of slaughter and death and destruction.Edward: Well, now you're just giving the machine gun a bad name.Michael: I. Who would, right. But like, and it, andEdward: it, it think of all the good the machine gun did, could like, butMichael: it affected the world. It definitely affected the world and you might say, well, it's better. I don't know if it is, but it certainly changed it. I'm saying that we're the press p where we might be getting outta control because now wars are, so, the reason why we don't get into a war with the U S S R right now, is because it'll be so destructive. Because we've evolved our technology to the point that we could just destroy the world many times over.Are we not just pivoting towards superheroes where we could destroy the world many times over through them? Frightened dead. I'm frightened.Edward: All right. Well, I think it is what it is though, Mike. I feels, it feels like, just like we couldn't hold back the machine gun in World War I, I don't think we hold back superheroes anymore.I feel like the cat's outta the bag or the Thor is out of the. Helicopter.Michael: The hammers outta the clasp towards bellsEdward: the hammers outta the clasp. It's the new catchy phrase, and you heard it here first.Michael: Kids. Kids these days and their sayings. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.superserious616.com

Tracy Kidder is the author of eleven books, including The Soul of a New Machine and Mountains Beyond Mountains. His latest is Rough Sleepers. “I do think it's an interesting challenge to try to write about virtue, with all that's always mixed with it. Some writers have said it's virtually impossible … but it's not impossible. … People who are really trying, struggling against the odds, I think they're worth writing about.” Show notes: tracykidder.com Kidder on Longform Kidder's Atlantic archive 01:00 “‘You Have to Learn to Listen': How a Doctor Cares for Boston's Homeless” (The New York Times • Jan 2023) 06:00 “The Good Doctor” (New Yorker • July 2000) 06:00 Mountains Beyond Mountains (Random House • 2009) 19:00 Good Prose (Kidder and Richard Todd • Random House • 2013) 21:00 House (Houghton Mifflin • 1985) Learn more about your ad choices. Visit podcastchoices.com/adchoices

Author Tracy Kidder has been described as a “master of narrative nonfiction.” Kidder won the Pulitzer Prize and National Book Award for his 1981 book, “The Soul of a New Machine,” about the development of cutting edge computers. He is the author of more than a dozen books including the acclaimed 2003 New York Times bestseller, “Mountains Beyond Mountains,” about the late global health pioneer Dr. Paul Farmer, co-founder of Partners In Health. The book is often assigned as required reading in colleges.The Washington Post says that Kidder writes about “the moral value of small victories in a world of big problems.”Homelessness is the focus of Kidder's latest bestselling book, “Rough Sleepers: Dr. Jim O'Connell's Urgent Mission to Bring Healing to Homeless People.” Kidder spent five years following Dr. O'Connell as he worked the streets of Boston. Kidder was moved by the people he met who were experiencing homelessness in Boston and wanted to tell their stories. “If you get to know them, to really look at them — and a lot of people never do — you realize that they're every bit as human as you and I, and that old adage, There but for the grace of God go I.”“The engine of every good story is human character,” said Kidder. His work has appeared in the New Yorker, Atlantic, and the New York Times but he insisted, “I'm a storyteller more than I am a journalist.”“I stopped thinking of myself as a journalist around the time of the Iraq War. I didn't want to be associated,” he explained. “Because there were so many lies told and so much bad reporting… it starts to taint the term. And then you have Fox News. …It's a wonderful profession, journalism. I believe in it utterly. But I want to see it practiced better.”Kidder says of his craft that “the techniques of storytelling don't belong exclusively to fiction.” Good writing should “be like a pane of glass. The writing itself should be interesting but it doesn't have to be flashy. I believe in immersion in the story that I've discovered.”

Dave Mengebier, the President and CEO of the Grand Traverse Regional Community Foundation, drops in to discuss the Community Development Coalition of Northwest Michigan, the Foundation's DEI work and how his team manages so many advisory groups.Please reach out to emergentcf@gmail.com if you have an idea for a guest or topicMentions Include:Dave MengebierGrand Traverse Regional Community Foundation (The Foundation)Community Development Coalition of Northwest MichiganBooks, Podcast and Music recommendations- Demystifying Disability: What to Know, What to Say, and How to Be an Ally by Emily Ladau- Braiding Sweetgrass: Indigenous Wisdom, Scientific Knowledge and the Teachings of Plants by Robin Wall Kimmerer - The Soul of A New Machine by Tracy KidderEvents/Learning OpportunitiesList of All upcoming conferencesAssociationsNational Association of Charitable Gift Planners (CGP)Advancement Network (AdNet)CEONetProNetCommACouncil on FoundationsAiPAmerican College of Financial ServicesMusicThanks to Andy Eppler for our intro MusicThanks to David Cutter Music for "Float Away

Using sophisticated brain imaging methods, scientists have observed that DMT enhanced the connectivity and communication between different brain regions and systems.Hyperconnectivity is having a profound impact on our lives. It is changing the way we work, the way we learn, the way we interact with each other, and the way we think. What happens, when the DMT experience goes Mega Cosmic?LIVE ON Digital Radio! http://bit.ly/3m2Wxom or http://bit.ly/40KBtlW http://www.troubledminds.org Support The Show! https://rokfin.com/creator/troubledminds https://patreon.com/troubledmindshttps://www.buymeacoffee.com/troubledminds https://troubledfans.comFriends of Troubled Minds! - https://troubledminds.org/friends Show Schedule Sun-Mon-Tues-Wed-Thurs 7-10pst iTunes - https://apple.co/2zZ4hx6Spotify - https://spoti.fi/2UgyzqMStitcher - https://bit.ly/2UfAiMXTuneIn - https://bit.ly/2FZOErSTwitter - https://bit.ly/2CYB71U-----------------------------------------------------------https://troubledminds.org/the-new-the-machine-elves-hyperconnectivity-of-all-things/https://bigthink.com/neuropsych/dmt-hyperconnects-brain/https://happymag.tv/what-are-machine-elves/https://bigthink.com/hard-science/4-different-types-multiverse/https://en.wikipedia.org/wiki/Indra%27s_nethttp://dharmateacherorder.org/indras-web/https://non-aliencreatures.fandom.com/wiki/Machine_Elfhttps://realitysandwich.com/machine-elves-dmt-entities/https://www.dailymail.co.uk/news/article-2521132/DMT-spirit-molecule-drug-used-Shamanic-ceremonies-sweeping-country.htmlhttps://www.livescience.com/54813-ayahuasca.htmlhttps://www.polygon.com/23668486/ai-furby-chatgpt-eldritch-horrorhttps://botanicalshaman.com/2018/03/15/the-full-and-comprehensive-history-of-dmt/

The time has come to reveal the new machine to everyone! It's here! I am so excited for this episode of the podcast. Let's check it out!   Thanks for listening. Please give the podcast a 5 star rating and review in Apple Podcasts.   I would love to hear your feedback. Send me an email with your feedback at lansinglawnservice@gmail.com Podcast Website: https://www.mowinginthedarkpodcast.com/ https://anchor.fm/mowinginthelight   12 Month Contract Template Editable Download https://www.mowinginthedarkpodcast.com/product-page/12-month-contract-for-lawn-snow-combined-100-editable   Follow your host Aaron Sutter on… Instagram @lansinglawnservice Youtube: www.youtube.com/lansinglawnservicellc and check out my business website: www.lansinglawnservice.com   Want to be on our Sticker Wall? Send your stickers to: Lansing Lawn Service LLC P.O. Box 454 Potterville, MI 48876   Check out My Favorite Lawn Care Gear: Werner, AC78, Quickclick Stabilizer, Aluminum https://amzn.to/2OTOfMf Wonder Grip WG318L Liquid-Proof Double-Coated/Dipped Natural Latex Rubber Work Gloves 13-Gauge Seamless Nylon, Large, Large https://amzn.to/2Ytjml6 Hodenn Zero Turn Lawn Mower Hitch - Fits Ariens & Gravely ZT-X: https://amzn.to/3jJmEua ECHO Black Diamond Trimmer Line: https://amzn.to/2GBEL7d   #lawncare #landscaping #mowinginthedark #lawnservice #lawncarebusiness #lawncarepodcast #greenindustry #mowing #lawnmowing #landscapingpodcast #lawnpodcast #greenindustrypodcast #fullertonunfiltered #greengrindpodcast

How can you turn a decades-old planter into an up-to-date planter? Talk to Precision Planting. Bryce Baker of Precision Planting was at Commodity Classic, at Orlando, Florida, earlier this month to discuss how you can upgrade your older equipment, and turn it into something more modern, for about half the price of a new implement.... Read More

New machine will allow Ashland law enforcement to drug test confiscated materials in minutes: https://www.richlandsource.com/news/new-machine-will-allow-ashland-law-enforcement-to-drug-test-confiscated-materials-in-minutes/article_32534402-c8e5-11ed-b3f7-df954e856c0a.html Today – When law enforcement in Ashland County confiscates a small amount of suspected narcotics, it can take weeks or months to get results back. But soon, that wait time will be reduced to minutesSupport the show: https://www.sourcemembers.com/See omnystudio.com/listener for privacy information.

Backing up your new machine on arrival can be an important safety net. But there are degrees of safety.

An airhacks.fm conversation with Dave Johnson (@snoopdave) about: PDP-8 with a paper tape reader, airhacks.tv questions and answers, TRS-80, playing asteroids, asteroids, Defender and Battlezone were based on vector graphics, learning Pascal and C, Data General Eclipse MV/8000, Geographic Resources Analysis Support System (GRASS GIS), working for University of Kingston, working on jfactory for Rouge Wave, HAHT Software, The Soul of a New Machine, distributed Visual Basic application server, using xdoclet to generate EJB, using castor for persistence, Apache Roller started as sample application, Sun hires dave, working on Lotus Notes social, starting at wayin, Roller supports Pingback, Lotus is using roller, using Rightscale to deploy Java software to AWS, using Jenkins and CloudFormation, episode with Scott McNealy "#19 SUN, JavaSoft, Java, Oracle", Roller uses Apache Velocity, working on RSS parser Rome, switching from MongoDB to Apache Cassandra, UserGrid data store, Oracle acquires apiary , starting at CloudBees, episode with Kohsuke Kawaguchi "#143 How Hudson and Jenkins happened", starting at Apollo, several thousand blogs on roller Dave Johnson on twitter: @snoopdave

Tracy Kidder has won the Pulitzer Prize, the National Book Award, and the Robert F. Kennedy Award, among other literary prizes. His books include Mountains Beyond Mountains, Strength in What Remains, The Soul of a New Machine, House, Among Schoolchildren, Old Friends, Hometown, and A Truck Full of Money. Learn more about your ad choices. Visit megaphone.fm/adchoices

Brandon transitioned from Honda to Yamaha a year ago. This is a whole new game since Brandon is trying to come from a Honda-backed program.Yamaha is the main part of the program so the people that make the program stable was key. Developing, growing, and moving forward Brandon's inner strength is the glue that keeps it together. Growth in education to not only develop his machine but his mind and body.Join us in this episode as Brandon talks about development, mind, and machine. Don't forget to share if you like this episode.

In today's episode of Category Visionaries, we speak with TJ Jermoluk, CEO of Beyond Identity, a passwordless authentication platform that's raised over $200 Million in funding, about why it's time to address the fundamental flaw in the way we've all been running our security. We all know that sharing passwords is a no-no, but it's built into the alphanumeric system on which our traditional security systems have been based for decades. By combining identity management and security infrastructure, Beyond Identity are carving out a new market category, and successfully bringing investors and clients along for the ride. We also spoke about TJ's legacy in Silicon Valley and the companies which helped to make him a legend there, why it's such a uniquely great place for starting a startup, and how it's changed over the decades. Leading the way in a new market space means confronting a whole host of unique challenges, foremost among which is educating your market about exactly why what you're offering is something they need, and how it's going to change their whole world. Topics Discussed: TJ's time in Silicon Valley, and why a unique combination of innovation and investment means its still a uniquely special place to do business Why most existing security solutions are just a ‘band aid on a gaping wound,' and how Beyond Identity is taking a totally different approach How seamless, password-free authentication can save a business time and money in the medium-long term How the .com crash changed the silicon valley ecosystem, and why some of the strongest companies emerged on the other side Why selling a unique vision to your customers might mean selling what seems impossible, and making it worth their money to support How Beyond Identity carved out a new market category by combining identity and security as twin priorities   Favorite book:  The Soul of A New Machine

Today's is a little more hardware-related (and Jim get's his nerd on BIG TIME) as Dave has bought a Mac Mini, and Jim has some great advice about moving to a new machine.  JOIN THE SCHOOL OF PODCASTING Join the School of Podcasting worry-free using the coupon code " ask" and save 20%. Your podcast will have you sounding confident, sound great (buying the best equipment for your budget), and have you syndicated all over the globe. There is a 30-day worry-free money-back guarantee Go to  https://courses.schoolofpodcasting.com/ask Sponsor: PodcastBranding.co If you need podcast artwork, lead agents or a full website, podcastbranding.co has you covered. Mark is a podcaster in addition to being an award-winning artist. He designed the cover art for the School of Podcasting, Podcast Rodeo Show, and Ask the Podcast Coach. Find Mark at  podcastbranding.co Mugshot: Based on a True Story Podcast Ever wonder how much of those "Based on a true story" movies are real? Find out at www.basedonatruestorypodcast.com Jim Steps For Migrating to a New Computer 1. Get rid of bloatware 2. Get the updates 3. Get familiar with the operating system 4. Run both systems for a while 5. Do you install Antivirus? 6. Backing up your computer 7. What do you do with your old PC? Become an Awesome Supporter Get Bonus Content Live Group Coaching www.askthepodcastcoach.com/awesome or consider a one-time donation. Mentioned In This Episode Featured supporter: Indie Drop In Network Synergy Software to share a mouse over two computers Backblaze Backup Your Computer Cigar Authority Podcast TOPICS and TIMELINE 2:52 The plot to every Christmas special.   6:28 What to do with your old hard drive.   10:51 How to get familiar with the operating system.   16:01 The magic word: learning curve.   20:22 What to do if you don't have any virus.   24:43 Dave's storage strategy.   29:33 What do you do with your old pc right now?   34:13 Do you have a problem outing a company?   39:26 The importance of visibility for brands that affiliate with a show that may be safe but the host is not.   43:43 What is errors and omissions insurance?   49:03 What's the consensus on fellow podcasters who reach out to be on your podcast?   53:30 How to get on other people's podcasts.   59:16 When you get a high-profile guest on your show, it makes it easier to get other guests.   1:03:56 The only time I ever get slightly upset is if somebody bumps me twice.   1:09:49 You never know who will agree to be on your show until you ask.   1:14:56 Is this type of podcast needed or not?   1:21:39 How Bruce Springsteen reinvented himself in the 80s.   Dave Garoppolo's business model.  

➤ Jimmy Soni, author of 'The Founders' joins Rob Maurer to discuss the early days of Elon Musk, the story of x.com and PayPal, where Twitter may be headed, and more. The Founders: https://amzn.to/3V7oGWZ The Soul of A New Machine: https://amzn.to/3jcqGzY Find Jimmy Soni on Twitter @jimmyasoni 0:00 Jimmy Soni & The Founders 0:41 Backstory on the book 4:38 Understanding Elon 10:22 Elon's early days and Twitter motivation 14:25 A vision unfulfilled 16:57 Being wrong 20:20 Organizational change 22:06 Speed 24:02 Elon forced out of PayPal 34:22 Elon's mindset and overcoming challenges 39:55 Elon's motivation & character 47:08 Engineering vs. the world 50:31 Filtering out the noise 53:08 Misconceptions Shareloft: https://www.shareloft.com Twitter: https://www.twitter.com/teslapodcast Patreon: https://www.patreon.com/tesladailypodcast Tesla Referral: https://ts.la/robert47283 Executive producer Jeremy Cooke Executive producer Troy Cherasaro Executive producer Andre/Maria Kent Executive producer Jessie Chimni Executive producer Michael Pastrone Executive producer Richard Del Maestro Executive producer John Beans Disclosure: Rob Maurer is long TSLA stock & derivatives. Product links may earn additional revenue for the channel.

As many New Zealanders prepare to hit the road for summer, the Waka Kotahi's getting ready for its regular holiday schedule of road resurfacing. Work will be carried out on about 10 percent of the country's state highways this summer. But what happens to the old road seal when new asphalt is laid on? Fulton Hogan has a new machine to deal with the leftovers in a more environmentally friendly way. Our reporter Tom Taylor and camera operator Nick Monro have the story.

This week's podcast is about the arrival of ChatGPT, which is stunning people everywhere with its content generation.You can listen to this podcast here, which has the slides and graphics mentioned. Also available at iTunes and Google Podcasts.Here is the link to the Asia Tech Tour.Here is the link to ChatGPTHere is the past article on Conversation AI at JD:3 Lessons in Conversational AI from JD's Head of the Deep Learning (1 of 2)——What is Elon Musk's Plan to 10x Twitter? (2 of 2) (Tech Strategy – Daily Article)From the Concept Library, concepts for this article are:AI as Cheap and Fast PredictionAI: NLPFrom the Company Library, companies for this article are:OpenAI———-Support the show

Diagnosing and containing a disease outbreak, or the health effects of a disruptive event like a natural disaster, can be a huge task. A study out Friday from New York University suggests that a new machine learning model could improve health officials’ ability to respond to future pandemics and other public health crises. The research was done in partnership with Carnegie Mellon University and New York City's Department of Health and Mental Hygiene. Marketplace’s Kimberly Adams speaks with Daniel Neill, a computer science professor at NYU and the director of its Machine Learning for Good Laboratory, which released the study. He explains how this machine learning model works.

Diagnosing and containing a disease outbreak, or the health effects of a disruptive event like a natural disaster, can be a huge task. A study out Friday from New York University suggests that a new machine learning model could improve health officials’ ability to respond to future pandemics and other public health crises. The research was done in partnership with Carnegie Mellon University and New York City's Department of Health and Mental Hygiene. Marketplace’s Kimberly Adams speaks with Daniel Neill, a computer science professor at NYU and the director of its Machine Learning for Good Laboratory, which released the study. He explains how this machine learning model works.

Rick Ptak joins Dominic Rubino to discuss the complicated topic of new machines. More people? Better process? I help you make sure you make the right decision when troubleshooting your workflow problems.

Today on the podcast we've got two guests who are each packing a lot of firepower. Known as Anonymous Bob and Rapid Fire Rachel in SASS (Single Action Shooting Society) circles, this father-daughter duo comes from a family of gun-loving Americans who wants to share their love for firearms with you. Today on the podcast Bob, Rachel, and I talk about how they each got into firearms, what they enjoy about firearms in their personal life, and also about an upcoming hopeful successor to the recently ended Knob Creek Machine Gun Shoot. Details on the machine gun shoot will be coming soon so if you're interested in possibly attending and participating in something like that be sure to keep tabs on both Bob's and Rachel's social media pages for more information on that event this fall. In the meantime, enjoy the show! 

It's A Wonderful Podcast is the home of MACHINE MONDAYS hosted by the Movie Trivia Schmoedown's Jeannine "The Machine"; the best place for Schmoedown fans to start their week!! This first Singles Title Match of the Schmoedown season was a battle of the old vs the new; as Samm Levine, fresh after making his impressive return to competition on last week's Friday Night Titans, went right into getting another title shot on a PPV this weekend!! Jeannine is here to break down that whole PPV, which also included a massive undercard with William Bibbiani facing Chance Ellison and as always this season, some very intriguing story developments!! The Machine Theme by David B. Music: https://open.spotify.com/artist/3qH2S05rz1fSP7geaYTxSl?si=rKN_y5a6T5KtbgrjQD8Kow Produced & Edited by Morgan Robinson for It's A Wonderful Podcast Join our Patreon: https://www.patreon.com/ItsAWonderful1 The Schmoedown Entertainment Network: https://www.youtube.com/channel/UCMVCs1F_XGueuaD9AfgTWmg IT'S A WONDERFUL PODCAST STORE: https://www.teepublic.com/user/g9design Sub to the feed and download now on Anchor, Apple Podcasts, Spotify, Stitcher & more and be sure to rate, review and SHARE AROUND!! Keep up with us on Twitter: Podcast: https://twitter.com/ItsAWonderful1 Jeannine: https://twitter.com/JeannineDaBean Schmoedown: https://twitter.com/TheSchmoedown XOXO Machine --- Send in a voice message: https://anchor.fm/itsawonderfulpodcast/message Support this podcast: https://anchor.fm/itsawonderfulpodcast/support

There are many ways to get Python installed on your computer. If you were going to start fresh, what tools would you use? What if you need to manage multiple versions of Python and virtual environments? What about all the additional tools that make your coding workflow complete? This week on the show, Calvin Hendryx-Parker is here to talk about bootstrapping your Python environment.

This week hosts Jim DeRogatis and Greg Kot share their favorite songs defined by their backing vocals, much like Merry Clayton left her mark on The Rolling Stones' song "Gimme Shelter." Plus they review the new album from Eleventh Dream Day and learn what they're missing in Brockhampton.Join our Facebook Group: https://bit.ly/3sivr9TBecome a member on Patreon: https://bit.ly/3slWZvcMake a donation via PayPal: https://bit.ly/3dmt9lURecord a Voice Memo: https://bit.ly/2RyD5Ah Featured Songs:The Rolling Stones, "Gimme Shelter," Let It Bleed, Decca, 1969BROCKHAMPTON, "BUZZCUT (feat. Danny Brown)," Roadrunner: New Light, New Machine, RCA, 2021BROCKHAMPTON, "THE LIGHT," Roadrunner: New Light, New Machine, RCA, 2021BROCKHAMPTON, "THE LIGHT PT. II," Roadrunner: New Light, New Machine, RCA, 2021BROCKHAMPTON, "DEAR LORD," Roadrunner: New Light, New Machine, RCA, 2021Eleventh Dream Day, "Since Grazed," Since Grazed, Comedy Minus One, 2021Eleventh Dream Day, "Tyrian Purple," Since Grazed, Comedy Minus One, 2021Eleventh Dream Day, "A Case to Carry On," Since Grazed, Comedy Minus One, 2021R.E.M., "Superman," Lifes Rich Pageant, I.R.S., 1986Stereolab, "French Disko," (Single), Duophonic, 1994The Beach Boys, "Sloop John B," Pet Sounds, Capitol, 1966Sam Cooke, "Bring It On Home to Me," (Single), RCA, 1962Billy Joel, "The Longest Time," An Innocent Man, Columbia, 1983The Turtles, "Elenore," The Turtles Present the Battle of the Bands, White Whale, 1968Laura Nyro and Labelle, "I Met Him on a Sunday," Gonna Take a Miracle, Columbia, 1971Ray Charles, "(Night Time Is) The Right Time," The Genius Sings the Blues, Atlantic, 1961David Bowie, "Young Americans," Young Americans, RCA, 1975Eric B. & Rakim, "Paid in Full," Paid in Full, Island, 1987