Podcasts about new machine

Earlier this month, a new Democratic machine scored a major victory in Connecticut. First-time congressional candidate Luke Bronin won his Democratic primary by a landslide, ousting 14-term progressive incumbent Rep. John Larson (D-Conn.). Bronin's win is part of a larger, national push — funded by a secretive hedge fund manager — to elect more establishment-aligned Democrats. Who is this man pouring his millions into the fight?   Today on Lever Time, David Sirota sits down with Lever reporters Katya Schwenk and Luke Goldstein to unmask the man behind the machine. They discuss Schwenk and Goldstein's recent hit article exploring how one billionaire Democratic donor is attempting to handpick corporate-friendly candidates and crush their most progressive opponents in this year's midterms.   You can check out more of Katya Schwenk and Luke Goldstein's reporting here: How A Hedge Fund Billionaire Became The Democrats' New Kingmaker The Democratic Primary Operative With A Wall Street Side Gig The New Democratic Machine – And The Billionaires Behind It Get ad-free episodes, bonus content and extended interviews by becoming a member at levernews.com/join. To leave a tip for The Lever, click here. It helps us do this kind of independent journalism. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode we feature one of the giants of story telling and of long form journalism, Tracy Kidder. Kidder passed away at the age of 80 in March 2026, and so we are sharing this recording from 2011 as a way for us to celebrate his life and work, and all that he has given to readers. Spanning over 50 years, Kidder's career began at the Iowa Writers Workshop where he enrolled in 1974 after military service in the Vietnam war. He began with aspirations to be a novelist but soon found that he had talent for seeing the through line of the lives of the people all around him. And so for his entire storied career, Kidder wrote compellingly about ordinary people from all walks of life, including carpenters, home builders, computer programmers, Haitian doctors, schoolchildren, and nursing home residents  – just to name a few. Along the way he earned a Pulitzer, a National Book Award, and the Robert F. Kennedy Book Award, for his ground breaking books like The Soul of a New Machine and Mountain Beyond Mountains. His body of work included dozens and dozens of articles, and twelve books, which came to redefine an entire genre of nonfiction. He joined us in 2011 after the publication of a book called Strength In What Remains, and he tells the story of learning to write in Iowa, and then his apprenticeship turned life-long professional relationship with Richard Todd who was one of the Atlantic Magazine's famed editors. It's an extraordinary story in which Kidder reveals his mistakes, uncertainties, and vulnerabilities as much as his successes. And he does so with self effacing humor and quiet wisdom. This is a must-listen for every aspiring writer, and for every reader who wants deeper insight into the creative process and to understand how many of the stories that have come to define modern journalism were made. Tracy Kidder graduated from Harvard and the University of Iowa. He won the Pulitzer Prize, the National Book Award, the Robert F. Kennedy Award, and many other literary prizes. He is the author of Rough Sleepers, A Truck Full of Money, Good Prose (with Richard Todd), Strength in What Remains, My Detachment, Mountains Beyond Mountains, Home Town, Old Friends, Among Schoolchildren, House, and The Soul of a New Machine. Kidder passed away in 2026.

David Epstein is General Partner at USF Ventures, the venture fund backing companies connected to the University of San Francisco. He was previously a General Partner at Crosslink Capital and has held management and CEO roles at more than half a dozen startups. He also teaches entrepreneurship and finance, and began his career at Data General as a computer designer, on the project chronicled in Tracy Kidder's Pulitzer Prize winning The Soul of a New Machine.In this episode, Dave argues that the real AI bottleneck isn't chips, power, or capital. It's data. We get into why frontier labs backing open weight models is a defensive move rather than a principled one, where early stage startups can still win, and why he thinks jobs will disappear faster than they get created.⭐This episode is brought to you by Podcast10x. We help founders and investors turn one podcast episode into a full month of content. Strategy, production, and distribution handled end to end. Learn more at https://podcast10x.comWhat we cover:→ Why "AI company" is no longer a category, and the pitch deck claim that has become his pet peeve→ Why AI isn't a tool anymore, and what makes this cycle different from the dot com era→ The real bottleneck: why we've exhausted the internet's data and what comes next→ Money as the constraint nobody prices in, and the circularity in the current data center build out→ How Chinese open weight models pull revenue out of token charges and subscriptions→ Why big lab support for open models is defensive positioning→ Who survives if open weights take share, and why consolidation is coming→ Where early stage startups can still win: drug discovery, financial services, legal→ Why the likely exit is a sale, not an IPO→ Ethical investing as a return rather than a tax, and why it's tough to work with jerks→ Why self-regulation rarely works, and what 2008 tells us about the current AI alliance→ Why layoffs are just the beginning, and the Industrial Revolution parallel everyone forgets→ Where the jobs actually are: management, human facing care, and the trades→ What top tier VCs get right, and why VCs are also lemmings→ Quantum computing as a data center accelerator, and the password problem it creates→ Physics AI vs physical AI, and the validation problem sitting on top of both→ Five year predictions: AGI, commonplace robots, and why consciousness doesn't matterConnect with Dave Epstein:LinkedIn: https://www.linkedin.com/in/thedavee/USF Ventures: https://usfventures.comConnect with Prashant Choubey:LinkedIn: https://linkedin.com/in/choubeysahabSubscribe to VC10X newsletter - https://vc10x.beehiiv.comVC10X website - https://vc10x.comTimestamps:(00:00) - Preview(00:56) - Introduction to David Epstein and the Episode's Topics(02:48) - How the AI Startup Landscape Has Fundamentally Changed(05:08) - Comparing the Current AI Boom to the Internet Boom(06:25) - Identifying the Next AI Bottleneck: Chips, Power, or Data?(09:30) - Why Money is an Overlooked Bottleneck for AI Development(11:14) - The Cyclical Nature of AI Investments and Financing(12:46) - Analyzing Big Tech's Support for Open Source Models(15:12) - Winners and Losers: Open Source vs. Frontier Models(18:01) - How Early-Stage Startups Can Compete and Win in the AI Space(20:53) - The Role of Ethics in AI Investment Decisions(23:31) - The Challenge of Upholding Ethics in a Competitive Market(26:21) - Implications of the OpenAI Model Escaping(29:46) - The Future of AI-Driven Job Disruption(32:46) - Where to Find Employment Opportunities in the AI World(37:43) - How Top-Tier VCs Evaluate Founders and Make Decisions(40:21) - The Most Exciting Emerging Areas of Innovation(43:18) - Explaining Quantum Computing's Potential and Impact(48:39) - An Ambitious AI Prediction for the Next 5 Years(51:35) - Rapid Fire Round: USF Ventures' Investment Strategy(53:06) - Conclusion

Why This Episode MattersYuval has a rare profile in the quantum industry: an M.Sc. in physics from Tel Aviv University, an MBA from Kellogg, two decades as a CEO and CMO in deep tech before quantum, and now the commercial lead at QuEra — the company whose neutral-atom architecture is colocated with NVIDIA H100s inside Japan's ABCI-Q supercomputer and just demonstrated 96 logical qubits from 448 physical atoms in Nature. He also hosts The Superposition Guy's Podcast and has just published Quantum Bits, a comic-book guide to quantum computing.This is a crossover conversation — Sebastian's book A New Quantum Era came out the same week — so the episode reads as two practitioners comparing their explanatory strategies, their reading of the modality race, and their honest forecasts for when a quantum computer becomes genuinely non-simulatable. If you want a candid look at how the commercial side of quantum thinks about hardware timelines, error-correction overhead, and the work of translating physics into procurement, this is the episode.SponsorThis episode is brought to you by Outshift, Cisco's incubation engine. The need for computational power is rapidly increasing in every sector. From drug discovery to material innovation to complex financial modeling, classical systems are reaching their absolute limits. It's time for a paradigm shift. The answer is a scalable quantum network, built on open standards and vendor-agnostic architecture. By uniting distributed quantum devices, you unlock limitless computational power.Learn more about the Cisco Universal Quantum Switch at Outshift.com.Go deeper with the blog post The switch that quantum networking has been waiting for.What We Get IntoWhy Vladan Vuletić's confidence horizon for neutral atoms expanded from 5 years to 10 years in a single 18-month window — and what changedThe honest case for neutral atoms when wall-clock speed is the obvious weakness: parallelism, algorithmic fault tolerance, and a 2:1 physical-to-logical ratio for quantum memoryWhy "time to solution" — not gate speed — is the metric Yuval thinks the industry should be arguing aboutHow Shor's algorithm went from requiring a million qubits to roughly 30,000, and what that compression means for cryptographically relevant timelinesThe craft problem of explaining quantum without saying "zero and one at the same time" — and why both Yuval and Sebastian refused to use itWhat it took to make a quantum comic funny in German (the German is perfect, the joke is not)Sebastian's read on the modality race: neutral atoms short-term, superconducting mid-term, spin and photonics long-term — and Yuval's pushbackWhy Yuval thinks Sebastian's five-year forecast for a non-simulatable machine is pessimisticThe shift inside QuEra from "95% science, 5% everything else" to a company that has to ship serviceable systems and uptimeHow podcasting becomes a business development tool once the microphone is offResources & LinksGuest LinksThe Superposition Guy's Podcast — Yuval's interview show with quantum CEOs and technical leaders across computing, sensing, and communications.Quantum Bits Comics — Yuval's comic-book guide to quantum computing, including custom editions and multilingual versions.QuEra Computing — The neutral-atom quantum computing company where Yuval serves as Chief Commercial Officer.Yuval's published writing — Aggregated Forbes, HPCwire, and Built In bylines on quantum ROI, workforce, and commercialization.Papers & ArticlesQuEra and collaborators on Algorithmic Fault Tolerance (Nature, 2025) — The paper behind the claim that syndrome measurements can happen per algorithmic block rather than per operation.HPCwire coverage of the AFT result — Independent take on the 10–100x runtime overhead reduction.IEEE Spectrum on neutral-atom quantum computing in 2026 — Context for the AIST Gemini deployment and Yuval's time-to-solution argument.2026 Quantum Readiness Report, Part 2 — The survey of 291 stakeholders behind Yuval's "show-me phase" framing of the market.BooksA New Quantum Era by Sebastian Hassinger — Sebastian's outsider's introduction to quantum computing, referenced throughout the conversation.Quantum Bits: A Comic Book Guide to Quantum Computing by Yuval Boger — Yuval's illustrated explainer, with a glossary covering terms from superposition to QLDPC codes.Background Reading MentionedThe Soul of a New Machine by Tracy Kidder — Sebastian's inspiration for the working title of his next book.Key Quotes & InsightsOn the magic of neutral atoms: "We've got this rubidium atoms, we hold them in place using tiny lasers, they're four microns apart, we shoot lasers, and then we take a photograph and see how they're doing. It's science fiction until it isn't."On the modality timeline (Yuval, paraphrasing Vladan Vuletić): Eighteen months ago Vladan was confident about neutral atoms for the next five years. Six months ago, after recent results, that confidence horizon stretched to ten.On what actually matters: "Obviously what matters is time to solution and not clock speed." Yuval's core rebuttal to the standard critique that neutral-atom gates are slow.On the error-correction compression: A recent Harvard result showed the physical-to-logical qubit ratio for quantum memory dropping toward roughly 2:1 — not the thousand-to-one figure that dominates most public discourse.On the takeaway from his book (Yuval): "Quantum is magical, but it's not magic."Related EpisodesEpisode 18 — Neutral atom arrays with Alex Keesling of QuEra Computing — Sebastian's earlier conversation with QuEra's CEO on the foundational technology.

In this episode we feature one of the giants of story telling and of long form journalism, Tracy Kidder. Kidder passed away at the age of 80 in March 2026, and so we are sharing this recording from 2011 as a way for us to celebrate his life and work, and all that he has given to readers. Spanning over 50 years, Kidder's career began at the Iowa Writers Workshop where he enrolled in 1974 after military service in the Vietnam war. He began with aspirations to be a novelist but soon found that he had talent for seeing the through line of the lives of the people all around him. And so for his entire storied career, Kidder wrote compellingly about ordinary people from all walks of life, including carpenters, home builders, computer programmers, Haitian doctors, schoolchildren, and nursing home residents  – just to name a few. Along the way he earned a Pulitzer, a National Book Award, and the Robert F. Kennedy Book Award, for his ground breaking books like The Soul of a New Machine and Mountain Beyond Mountains. His body of work included dozens and dozens of articles, and twelve books, which came to redefine an entire genre of nonfiction. He joined us in 2011 after the publication of a book called Strength In What Remains, and he tells the story of learning to write in Iowa, and then his apprenticeship turned life-long professional relationship with Richard Todd who was one of the Atlantic Magazine's famed editors. It's an extraordinary story in which Kidder reveals his mistakes, uncertainties, and vulnerabilities as much as his successes. And he does so with self effacing humor and quiet wisdom. This is a must-listen for every aspiring writer, and for every reader who wants deeper insight into the creative process and to understand how many of the stories that have come to define modern journalism were made. Tracy Kidder graduated from Harvard and the University of Iowa. He won the Pulitzer Prize, the National Book Award, the Robert F. Kennedy Award, and many other literary prizes. He is the author of Rough Sleepers, A Truck Full of Money, Good Prose (with Richard Todd), Strength in What Remains, My Detachment, Mountains Beyond Mountains, Home Town, Old Friends, Among Schoolchildren, House, and The Soul of a New Machine. Kidder passed away in 2026.

Bookwaves/Artwaves is produced and hosted by Richard Wolinsky. Links to assorted local theater & book venues   Tracy Kidder (1945-2026):  Pulitzer Winning Non-Fiction Author Tracy Kidder (1945-2026), Pulitzer Prize winning author of literary non-fiction, in conversation with Richard Wolinsky, recorded in the KPFA studios during the book tour for “Strength in What Remains: A Journey of Remembrance and Forgiveness, ” which focuses on the extraordinary true story of Deo, a young man who arrives in America from Burundi in search of a new life. Tracy Kidder, who died of lung cancer on March 24, 2026 at the age of eighty, was best known for his literary journalism, for turning non-fiction narratives into literary masterpieces. The author of eleven books, he won the Pulitzer Prize for General Nonfiction and the National Book Award for Nonfiction in 1982 for The Soul of A New Machine, which looked at the tech environment during the birth of the modern computer. His 1990 book, Among Schoolchildren, a close look at American education, focusing on twenty students in a Massachusetts elementary school, won several literary awards. In the years after the interview, Tracy Kidder went on to write three more non-fiction books. His final book to date, Rough Sleepers: Dr. Jim O'Connell's Urgent Mission to Bring Healing to Homeless People was published in 2023. Paul Farmer, the subject of Tracy Kidder's 2003 book “Mountains Beyond Mountains”, died in February, 2022.   Joseph Kanon: Spy Thriller Novelist Joseph Kanon, in conversation with Richard Wolinsky, recorded June 17, 2017 during the book tour for the spy thriller “Defectors.” Over the course of the last thirty years, Joseph Kanon has established himself as one of the best spy novelists around, in the vein of John Le Carre, Alan Furst, Graham Greene and Eric Ambler. His latest novel, “Defectors,” is about what happens after a Soviet mole defects to Russia. What is their life like? What happens then? Set in the early 1960s, “Defectors,” through copious research, sets up what life must have been like for people like Kim Philby and other Russian spies forced to leave the West to survive. Joseph Kanon's most recent novel, “Shanghai” was published in 2024.   Review of “The Goat or Who Is Sylvia”” at Shotgun Players Ashby Stage through April 28, 2026.     Book Interview/Events and Theatre Links updated April 14, 2026 Note: Shows may unexpectedly close early or be postponed due to actors' positive COVID tests. Check the venue for closures, ticket refunds, and mask requirements before arrival. Dates are in-theater performances unless otherwise noted. Some venues operate Tuesday – Sunday; others for shorter periods each week. All times Pacific Time. Closing dates are sometimes extended. Book Stores Bay Area Book Festival  See website for highlights from the 110th Annual Bay Area Book Festival, May 31 – June 1, 2025. Book Passage.  Monthly Calendar. Mix of on-line and in-store events. Books Inc.  Mix of on-line and in-store events. The Booksmith.  Monthly Event Calendar. BookShop West Portal. Monthly Event Calendar. Center for Literary Arts, San Jose. See website for Book Club guests in upcoming months. Green Apple Books. Events calendar. Kepler's Books  On-line Refresh the Page program listings. Live Theater Companies Actors Ensemble of Berkeley.  See website for readings and events. Actor's Reading Collective (ARC).  See website for upcoming productions. African American Art & Culture Complex. See website for calendar. American Conservatory Theatre  ||: Girls :||: Chance :||: Music :||. through April 19, Strand Theatre. Hamnet, adapted by Lolita Chakrabarti, April 22 – May 24, Toni Rembe (Geary).  Awesome Theatre Company. See website for information. BATS Improv Improvised theatre. See website for schedule. BATS Bayfront Theatre, Fort Mason Center, San Francisco. Berkeley Playhouse. Cats, May 22 – June 21.  Berkeley Rep. The Monsters by Ngozi Anyanwu, March 27 – May 3, Peets Theatre. The Lunchbox, World Premiere Musical, May 17 – June 28, Berkeley Shakespeare Company See website for upcoming productions. Brava Theatre Center: See calendar for events listings. BroadwaySF: Hadestown, April 21 -26,  Orpheum.  Hells Kitchen, May 6 – 24, Orpheum. See website for complete listings for the Orpheum, Golden Gate and Curran Theaters. note: BroadwaySF is now ATG Tickets. Broadway San Jose:  Les Miserables, April 29 – May 3. Back to the Future, June 2 – 7. The Sound of Music, July 21-26, Center REP: Lost in Yonkers by Neil Simon, March 29 – April 19. Central Stage. See website for upcoming productions, 5221 Central Avenue, Richmond Central Works The Prince, Parts I & 2 by Gary Graves, July 18 – Sept. 26. Rotating. See website for schedule. Cinnabar Theatre. The Christians by Lucas Hnath, April 10-26, The Secret Garden, June 12 – 28. Club Fugazi. Dear San Francisco, ongoing. Closed Monday and Tuesday. Contra Costa Civic Theatre A Chorus Line, June 6 – 21, 2026. See website for other events and concerts. Golden Thread  Festival of Palestinian Art, April 9-19, Potrero Stage..See website for details and specifics. Hillbarn Theatre: The Play That Goes Wrong by Henry Lewis, Jonathan Sayer & Henry Shields, April 23 – May 17. Lorraine Hansberry Theatre. 2026 season: Sistahfriend by Phaedra Tillery-Boughton, Magic Theatre, May 15-17; African Stew by Dr. Lisa B. Thompson, Sept. 10-27. Magic Theatre; Soulful Christmas, December, Magic Theatre. Los Altos Stage Company. The Cherry Orchard by Anton Chekhov, adapted by Tom Stoppard, April 16 – May 10. Lower Bottom Playaz  See website for upcoming productions. Magic Theatre. A Back with Two Beasts Productions presents Shades and Shadows, a world premiere play by William Brasse, April 30 – May 3. Marin Shakespeare Company: La Comedia of Errors, April 17 – May 10, As You Like It, June 19 – July 19, Julius Caesar, August 14 – Setpember 13, See website for schedule. Marin Theatre:  60th Anniversary Gala, April 19. Pictures from Home by Sharr White, May 7-31. Masquers Playhouse, Point Richmond. The Gods of Comedy by Ken Ludwig, April 24 – May 17. Mission Cultural Center for Latino Arts Closed. SF Chronicle gift article. New Conservatory Theatre Center (NCTC) how to make an American Son By Christopher Oscar Peña, Walker Theatre, April 3 – May 10. Silent Movie written & directed by Stephanie Temple, April 24 – May 3, Tucker Theatre. New Performance Traditions.  See website for upcoming schedule Oakland Theater Project. Assassins, March 29 – extended to April 19. The House of Bernarda Alba by by Federico Garcia Lorca, adapted by Chay Yew, May 22 – June 7. The Fre by Taylor Mac, June 18-28. Odd Salon: Upcoming events in San Francisco & New York, and streaming. Palace of Fine Arts Theater.  See website for event listings. Pear Theater. Anon(ymous) an adaptation of the Odyssey, by Naomi Iizuka, April 18 – May 3, God of Carnage by Yazmina Reza, June 12 – 28. See website for staged readings and other events. Playful People Productions. See website for classes and upcoming events. . Presidio Theatre. See website for complete schedule of events and performances. Ray of Light: Mean Girls The Musical. May 1 – 30. Urinetown, July 31 – August 29. New Venue: The Barbary Stage (formerly The Gateway), Jackson Square, SF. Ross Valley Players: See website for New Works Sunday night readings and other events. San Francisco Playhouse. Flex by Candrice Jones. March 26 – May 7.. SFBATCO.  See website for streaming and in- theater shows. San Francisco Shakespeare Festival. Shakespeare on Tour: Julius Caesar, through May. See website for more information. San Jose Stage Company: See website for events and upcoming season Shotgun Players.  The Goat, or Who Is Sylvia by Edward Albee, extended to May 3, and cannot extend further. South Bay Musical Theatre:  On The Twentieth Century, April 19-20. SPARC: See website for upcoming events. Stagebridge: See website for events and productions. Storytime every 4th Saturday. The Breath Project. Streaming archive. The Marsh: Calendar listings for Berkeley, San Francisco and Marshstream. Theatre Lunatico  See website for upcoming productions.. Theatre Rhino  La Cage aux Folles, May 7 – June 7. Streaming: Essential Services Project, conceived and performed by John Fisher, all weekly performances now available on demand. TheatreWorks Silicon Valley Come from Away,  April 15 – May 10, Mountain View Center for the Performing Arts.The Employee Dharma Handbook by Geetha Ready, world premiere, July 8 – Aug 2, Lucie Stern Theatre, Palo Alto. Word for Word.  See website for upcoming productions. Misc. Listings: BAMPFA: On View calendar for Berkeley Art Museum and Pacific Film Archive. Berkeley Symphony: See website for listings. Chamber Music San Francisco: Calendar, 2025 Season. Dance Mission Theatre. On stage events calendar. Fort Mason Center. Events calendar. Oregon Shakespeare Festival: Calendar listings and upcoming shows. San Francisco Gay Men's Chorus. See schedule for upcoming SFGMC performances. San Francisco Opera. Calendar listings. San Francisco Symphony. Calendar listings. Filmed Live Musicals: Searchable database of all filmed live musicals, podcast, blog. League of Livestream Theatre: See website for streaming plays. If you'd like to add your bookstore or theater venue to this list, please write Richard@kpfa.org   . y. The post Bookwaves/Artwaves – April 2, 2026 – Tracy Kidder – Joseph Kanon appeared first on KPFA.

Tracy Kidder (1945-2026), Pulitzer Prize winning author of literary non-fiction, in conversation with Richard Wolinsky, recorded in the KPFA studios during the book tour for “Strength in What Remains: A Journey of Remembrance and Forgiveness, ” which focuses on the extraordinary true story of Deo, a young man who arrives in America from Burundi in search of a new life. Tracy Kidder, who died of lung cancer on March 24, 2026 at the age of eighty, was best known for his literary journalism, for turning non-fiction narratives into literary masterpieces. The author of eleven books, he won the Pulitzer Prize for General Nonfiction and the National Book Award for Nonfiction in 1982 for The Soul of A New Machine, which looked at the tech environment during the birth of the modern computer. His 1990 book, Among Schoolchildren, a close look at American education, focusing on twenty students in a Massachusetts elementary school, won several literary awards. In the years after the interview, Tracy Kidder went on to write three more non-fiction books. His final book to date, Rough Sleepers: Dr. Jim O'Connell's Urgent Mission to Bring Healing to Homeless People was published in 2023. Paul Farmer, the subject of Tracy Kidder's 2003 book “Mountains Beyond Mountains”, died in February, 2022. The post Tracy Kidder (1945-2026), Pulitzer Prize Winning Non-Fiction Author appeared first on KPFA.

Tech journalist Marshall Kirkpatrick joins the panel to showcase a new AI-powered tool that doesn't just summarize articles—it thinks like a journalist, flagging what's truly new and revealing the patterns that matter. If you want to stay several steps ahead in the AI race, this episode is a must-listen. Malware autodownloaded by AI agents Meta loses trial after arguing child exploitation was "inevitable" on its apps We're saying goodbye to the Sora app. To everyone who created with Sora, shared it, and built community around it: thank you. What you made with Sora mattered, and we know this news is disappointing. TurboQuant: Redefining AI efficiency with extreme compression Apple Can 'Distill' Google's Big Gemini Model Apple Plans AI Reboot With Siri App, New Look and 'Ask Siri' Button in iOS 27 Google Search referrals to the web have plummeted, AI links are 'less than 1%' of traffic A US appeals court puts on hold an earlier ruling that had blocked Perplexity from using its agentic shopping tool to shop on Amazon's marketplace A look at "tokenmaxxing", a status game where employees at a number of companies compete on leaderboards to show how much AI they're using Elon Musk Announces $20B 'Terafab' Chip Plant in Texas To Supply His Companies Jury finds Elon Musk guilty of defrauding Twitter investors [U] Tracy Kidder, Author of 'The Soul of a New Machine,' Dies at 80 AI Doc trailer reflect — Time-Travel Reflection for Obsidian Esoteric Ebb Butthole Regex Blaster Hosts: Leo Laporte, Jeff Jarvis, and Paris Martineau Guest: Marshall Kirkpatrick Download or subscribe to Intelligent Machines at https://twit.tv/shows/intelligent-machines. Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit Sponsors: outsystems.com/twit spaceship.com/twit

Tech journalist Marshall Kirkpatrick joins the panel to showcase a new AI-powered tool that doesn't just summarize articles—it thinks like a journalist, flagging what's truly new and revealing the patterns that matter. If you want to stay several steps ahead in the AI race, this episode is a must-listen. Malware autodownloaded by AI agents Meta loses trial after arguing child exploitation was "inevitable" on its apps We're saying goodbye to the Sora app. To everyone who created with Sora, shared it, and built community around it: thank you. What you made with Sora mattered, and we know this news is disappointing. TurboQuant: Redefining AI efficiency with extreme compression Apple Can 'Distill' Google's Big Gemini Model Apple Plans AI Reboot With Siri App, New Look and 'Ask Siri' Button in iOS 27 Google Search referrals to the web have plummeted, AI links are 'less than 1%' of traffic A US appeals court puts on hold an earlier ruling that had blocked Perplexity from using its agentic shopping tool to shop on Amazon's marketplace A look at "tokenmaxxing", a status game where employees at a number of companies compete on leaderboards to show how much AI they're using Elon Musk Announces $20B 'Terafab' Chip Plant in Texas To Supply His Companies Jury finds Elon Musk guilty of defrauding Twitter investors [U] Tracy Kidder, Author of 'The Soul of a New Machine,' Dies at 80 AI Doc trailer reflect — Time-Travel Reflection for Obsidian Esoteric Ebb Butthole Regex Blaster Hosts: Leo Laporte, Jeff Jarvis, and Paris Martineau Guest: Marshall Kirkpatrick Download or subscribe to Intelligent Machines at https://twit.tv/shows/intelligent-machines. Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit Sponsors: outsystems.com/twit spaceship.com/twit

Tech journalist Marshall Kirkpatrick joins the panel to showcase a new AI-powered tool that doesn't just summarize articles—it thinks like a journalist, flagging what's truly new and revealing the patterns that matter. If you want to stay several steps ahead in the AI race, this episode is a must-listen. Malware autodownloaded by AI agents Meta loses trial after arguing child exploitation was "inevitable" on its apps We're saying goodbye to the Sora app. To everyone who created with Sora, shared it, and built community around it: thank you. What you made with Sora mattered, and we know this news is disappointing. TurboQuant: Redefining AI efficiency with extreme compression Apple Can 'Distill' Google's Big Gemini Model Apple Plans AI Reboot With Siri App, New Look and 'Ask Siri' Button in iOS 27 Google Search referrals to the web have plummeted, AI links are 'less than 1%' of traffic A US appeals court puts on hold an earlier ruling that had blocked Perplexity from using its agentic shopping tool to shop on Amazon's marketplace A look at "tokenmaxxing", a status game where employees at a number of companies compete on leaderboards to show how much AI they're using Elon Musk Announces $20B 'Terafab' Chip Plant in Texas To Supply His Companies Jury finds Elon Musk guilty of defrauding Twitter investors [U] Tracy Kidder, Author of 'The Soul of a New Machine,' Dies at 80 AI Doc trailer reflect — Time-Travel Reflection for Obsidian Esoteric Ebb Butthole Regex Blaster Hosts: Leo Laporte, Jeff Jarvis, and Paris Martineau Guest: Marshall Kirkpatrick Download or subscribe to Intelligent Machines at https://twit.tv/shows/intelligent-machines. Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit Sponsors: outsystems.com/twit spaceship.com/twit

Tech journalist Marshall Kirkpatrick joins the panel to showcase a new AI-powered tool that doesn't just summarize articles—it thinks like a journalist, flagging what's truly new and revealing the patterns that matter. If you want to stay several steps ahead in the AI race, this episode is a must-listen. Malware autodownloaded by AI agents Meta loses trial after arguing child exploitation was "inevitable" on its apps We're saying goodbye to the Sora app. To everyone who created with Sora, shared it, and built community around it: thank you. What you made with Sora mattered, and we know this news is disappointing. TurboQuant: Redefining AI efficiency with extreme compression Apple Can 'Distill' Google's Big Gemini Model Apple Plans AI Reboot With Siri App, New Look and 'Ask Siri' Button in iOS 27 Google Search referrals to the web have plummeted, AI links are 'less than 1%' of traffic A US appeals court puts on hold an earlier ruling that had blocked Perplexity from using its agentic shopping tool to shop on Amazon's marketplace A look at "tokenmaxxing", a status game where employees at a number of companies compete on leaderboards to show how much AI they're using Elon Musk Announces $20B 'Terafab' Chip Plant in Texas To Supply His Companies Jury finds Elon Musk guilty of defrauding Twitter investors [U] Tracy Kidder, Author of 'The Soul of a New Machine,' Dies at 80 AI Doc trailer reflect — Time-Travel Reflection for Obsidian Esoteric Ebb Butthole Regex Blaster Hosts: Leo Laporte, Jeff Jarvis, and Paris Martineau Guest: Marshall Kirkpatrick Download or subscribe to Intelligent Machines at https://twit.tv/shows/intelligent-machines. Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit Sponsors: outsystems.com/twit spaceship.com/twit

Tech journalist Marshall Kirkpatrick joins the panel to showcase a new AI-powered tool that doesn't just summarize articles—it thinks like a journalist, flagging what's truly new and revealing the patterns that matter. If you want to stay several steps ahead in the AI race, this episode is a must-listen. Malware autodownloaded by AI agents Meta loses trial after arguing child exploitation was "inevitable" on its apps We're saying goodbye to the Sora app. To everyone who created with Sora, shared it, and built community around it: thank you. What you made with Sora mattered, and we know this news is disappointing. TurboQuant: Redefining AI efficiency with extreme compression Apple Can 'Distill' Google's Big Gemini Model Apple Plans AI Reboot With Siri App, New Look and 'Ask Siri' Button in iOS 27 Google Search referrals to the web have plummeted, AI links are 'less than 1%' of traffic A US appeals court puts on hold an earlier ruling that had blocked Perplexity from using its agentic shopping tool to shop on Amazon's marketplace A look at "tokenmaxxing", a status game where employees at a number of companies compete on leaderboards to show how much AI they're using Elon Musk Announces $20B 'Terafab' Chip Plant in Texas To Supply His Companies Jury finds Elon Musk guilty of defrauding Twitter investors [U] Tracy Kidder, Author of 'The Soul of a New Machine,' Dies at 80 AI Doc trailer reflect — Time-Travel Reflection for Obsidian Esoteric Ebb Butthole Regex Blaster Hosts: Leo Laporte, Jeff Jarvis, and Paris Martineau Guest: Marshall Kirkpatrick Download or subscribe to Intelligent Machines at https://twit.tv/shows/intelligent-machines. Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit Sponsors: outsystems.com/twit spaceship.com/twit

Tech journalist Marshall Kirkpatrick joins the panel to showcase a new AI-powered tool that doesn't just summarize articles—it thinks like a journalist, flagging what's truly new and revealing the patterns that matter. If you want to stay several steps ahead in the AI race, this episode is a must-listen. Malware autodownloaded by AI agents Meta loses trial after arguing child exploitation was "inevitable" on its apps We're saying goodbye to the Sora app. To everyone who created with Sora, shared it, and built community around it: thank you. What you made with Sora mattered, and we know this news is disappointing. TurboQuant: Redefining AI efficiency with extreme compression Apple Can 'Distill' Google's Big Gemini Model Apple Plans AI Reboot With Siri App, New Look and 'Ask Siri' Button in iOS 27 Google Search referrals to the web have plummeted, AI links are 'less than 1%' of traffic A US appeals court puts on hold an earlier ruling that had blocked Perplexity from using its agentic shopping tool to shop on Amazon's marketplace A look at "tokenmaxxing", a status game where employees at a number of companies compete on leaderboards to show how much AI they're using Elon Musk Announces $20B 'Terafab' Chip Plant in Texas To Supply His Companies Jury finds Elon Musk guilty of defrauding Twitter investors [U] Tracy Kidder, Author of 'The Soul of a New Machine,' Dies at 80 AI Doc trailer reflect — Time-Travel Reflection for Obsidian Esoteric Ebb Butthole Regex Blaster Hosts: Leo Laporte, Jeff Jarvis, and Paris Martineau Guest: Marshall Kirkpatrick Download or subscribe to Intelligent Machines at https://twit.tv/shows/intelligent-machines. Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit Sponsors: outsystems.com/twit spaceship.com/twit

Is a masterpiece still a masterpiece if no one suffered to create it? This week on The Heavy Metal Hangover, Rex and Duff are stepping back from the headlines to have a massive philosophical debate: Does human effort matter in the age of AI? We're exploring the shifting value of art in 2026 and asking what happens to our connection as listeners when the barrier to creation drops to zero. We dive into why certain genres—especially those built on "functional" sound or background vibes—are folding to the algorithm, while others are digging in their heels. Most importantly, we discuss the unique psychology of the Metal Fandom. In a genre that worships technical mastery, physical endurance, and raw emotional "blood on the tracks," is an AI-generated riff actually worth anything to us? We look at the "Authenticity Tax" and why the metal community's obsession with the human struggle might make us the last true defenders of the artist's soul. Join us for a heavy conversation about the future of what it means to be a fan.

It's episode 228 and time for us to talk about Computers and Computer Science books! We discuss technology, digital humanities, coding, and more! You can download the podcast directly, find it on Libsyn, or get it through Apple Podcasts or your favourite podcast delivery system. In this episode Anna Ferri | Meghan Whyte | Matthew Murray

In just five years, BROCKHAMPTON became a Hip-Hop comet, shooting by with seven albums and it could've been more! With those works, they went from free-wheeling Mixtape-sounding albums to more mature works lyrically and sonically. Its obvious that they couldn't have existed in previous eras but could it be done ever again?TIMESTAMPS:Weekly Music Roundup - (1:06)Ben:Don Toliver - OctaneLord Jah Monte Ogbon - As of NowLooking at Birds - Living RoomBy Storm x Injury Reserve - My Ghosts go GhostJordan Ward - BACKWARDWale the Sage - Hug Me As If We Were To Die TomorrowNafe Smallz - It's Not You It's MeThe Game x DJ Drama - Gangsta Grillz EMNTZu - Ferrum SidereumSkrillex - KoraLabrinth - COSMIC OPERA ACT ICharlie:Terrace Martin - PASSIONPJ - Why Do Feelings Matter AnywayLabrinth - COSMIC OPERA ACT ITeeZandos - STILL ODDNija - What I Didn't SayXV & MIKE SUMMERS - The Kid With The Green BackpackTopic Intro/Ben's Research House - (15:00)Saturation - (20:26)Saturation II - (26:45)Saturation III - (36:18)Iridescence - (46:00)Ginger - (53:54)Roadrunner: New Light, New Machine - (1:00:26)The Family - (1:05:41)TM - (1:09:48)Lighter Note - (1:18:34)Thanks for listening. Below are the Social accounts for all parties involved.Music - "Pizza And Video Games" by Bonus Points (Thanks to Chillhop Music for the right to use)HHBTN (Twitter & IG) - @HipHopNumbers5E (Twitter & IG) - @The5thElementUKChillHop (Twitter) - @ChillhopdotcomBonus Points (Twitter) - @BonusPoints92Other Podcasts Under The 5EPN:"What's Good?" W/ Charlie TaylorIn Search of SauceBlack Women Watch...5EPN RadioThe Beauty Of Independence

It's episode 222 and time for us to talk about books from the 1980s! Okay, I say "books" but it's really "science fiction and fantasy novels from the 1980s." You probably could have guessed that if you've listened to the podcast before. You can download the podcast directly, find it on Libsyn, or get it through Apple Podcasts or your favourite podcast delivery system. In this episode Anna Ferri | Meghan Whyte | Matthew Murray

On this urgent episode of the Hard Asset Money Show, Christian Briggs strips the hype from the AI revolution and explains what it really means for your job, your portfolio, and the broader economy. From software copilots to physical robotics, AI is now automating work across medicine, law, accounting, logistics, aviation, and the home—driving a wave of layoffs that's only just begun. Briggs breaks down why this isn't a dot-com rerun: it's a structural shift powered by massive data centers, semiconductors, and autonomous systems—with real risks, including black-box decisioning, skill erosion, and the concentration of power in a handful of platforms. Most importantly, he lays out where the economic value is likely to accrue (compute, power, metals, and secure data infrastructure), how workers can future-proof with AI-native skills, and why owning real assets can hedge the volatility of the machine age. It's not just about technology—it's about survival strategies in a world where your next boss might be an algorithm.

Is that new machine really worth the money? Just because the salesman says it'll pay for itself doesn't mean it will. In this episode, Dominic Rubino talks with Kolin Veldman from K&S Woodworks about the real ROI of large purchases in a cabinet/millwork shop. What you'll learn in this episode: 1. How to decide when your shop is ready for a CNC 2. Why “buy what you need today, not what you dream of tomorrow” is smart advice 3. The true costs behind new equipment (training, utilities, maintenance) 4. Why professional development for your team might be the best investment 5. How Kolin grew from a dairy barn shop to a $5M business without losing sleep over debt

This podcast is a little different as Katie isn't hosting. But is part of this powerful collaboration and partnership that has never been done before, so had to share across the podcast platform. We see time and time again, salons and clinics invest in machines hoping thats going to fix their business and bring in an influx of new clients. Unfortunately thats not the case. We also see people invest in machines and get the most basic of training so don't get the results. Katie Godfrey, Chelsea from Skin 13 Training academy and The Contour Group come together to solve this problem. Supporting the industry like never before. Please reach out to Katie on info@kgbusinessmentor.com or drop her a message on Instagram if you would like more info on machines so she can point you in the right direction. @kg_katiegodfrey https://www.contourgroup.co.ukSkin13 Training Academy

Guest: Rick Caccia, CEO and Co-Founder, Witness AI Topics: In what ways is the current wave of enterprise AI adoption different from previous technology shifts? If we say “but it is different this time”, then why? What is your take on “consumer grade AI for business” vs enterprise AI? A lot of this sounds a bit like the CASB era circa 2014. How is this different with AI?  The concept of "routing prompts for risk and cost management" is intriguing. Can you elaborate on the architecture and specific AI engines Witness AI uses to achieve this, especially for large global corporations?  What are you seeing in the identity space for AI access? Can you give us a rundown of the different tradeoffs teams are making when it comes to managing identities for agents?  Resources: EP226 AI Supply Chain Security: Old Lessons, New Poisons, and Agentic Dreams EP173 SAIF in Focus: 5 AI Security Risks and SAIF Mitigations EP84 How to Secure Artificial Intelligence (AI): Threats, Approaches, Lessons So Far Witness AI blog Shadow Agents: A New Era of Shadow AI Risk in the Enterprise Blocking shadow agents won't work. Here's a more secure way forward Shadow AI Strikes Back: Enterprise AI Absent Oversight in the Age of Gen AI Cloud CISO Perspectives: How Google secures AI Agents “The Soul of a New Machine” book Emoji Attack: A Method for Misleading Judge LLMs in Safety Risk Detection  

From Jorja Smith and Aitch, to Plan B and Maverick Sabre, New Machine (a.k.a. Adam Jordan) has worked with some of the biggest names in music. He told us how he got introduced to music, his first time in the studio and how he didn't and still doesn't know what's next in his career.Adam grew up between London and Wexford and he explained how that affected his music tastes and made him aware of the importance of listening to different voices and influences.He also gave us his advice for aspiring Irish musicians and explained the big shift in the UK scene that made it blow up.This episode was sponsored by Rightstyle Furniture - RIGHT PRICE, RIGHT STYLE, RIGHT NOW. Visit rightstyle.ie

In this episode, we're exploring new machine learning agents—redefining digital assistance.Try AI Box: ⁠⁠https://aibox.aiAI Chat YouTube Channel: https://www.youtube.com/@JaedenSchaferJoin my AI Hustle Community: https://www.skool.com/aihustle

The most common complaint about Windows 11 is based on a fallacy.

WEEK IN GEEK: Andrew finishes up Cobra Kai, while D. Bethel finds a wonderful world to explore in Prince of Persia: The Lost Crown. BRAVE NEW CAPTAIN: D. Bethel rounds out the episode discussing his (mostly spoiler-free) thoughts of Captain America: Brave New World. On the whole, he liked it! TOPICS: (00:00) Intro - February's over, suddenly! (01:45) Andrew's WiG: The end of Cobra Kai (31:51) D. Bethel's WiG: Prince of Persia: The Lost Crown (45:20) Outro - D.'s thoughts of Captain America: Brave New World (mild spoilers) (52:21) Outtakes RELEVANT EPISODES: "Too Many Johnnies" (5 February 2021): Where our hosts have their first big sit-down conversation about Cobra Kai. "Full Frasier" (16 September 2022): Where Andrew discusses the fifth season of Cobra Kai. "New Machine, New Problems" (29 November 2024): Where Andrew shares his thoughts on the first part of Cobra Kai, season 6. INFO: Visit our website at forallintents.net and leave your thoughts as comments on the page for this episode. Join our Facebook page Social: Andrew - Mastodon, D. Bethel - Instagram Subscribe to our YouTube channel. FEATURED MUSIC: "Disco Medusae" by Kevin McLeod Link: https://incompetech.filmmusic.io/song/3652-disco-medusae "District Four" by Kevin McLeod Link: https://incompetech.filmmusic.io/song/3662-district-four Tracks are licensed under Creative Commons BY Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/

Moving applications and data to a new machine isn't hard; it's just a fair amount of work.

01. Husky & Sydney Jo Jackson - Get Down (Birdee Extended Remix) 02. Kisch - Dive Deep (Extended Mix) 03. Ferreck Dawn x New Machine x Maverick Sabre - For The Weekend (Extended Mix) 04. Kevin McKay, NYLA - 2 On (Kevin McKay & Ludo Lacoste Extended VIP) 05. Milk & Sugar, James Hurr - I Love Music (Extended Mix) 06. Mercer - In My Arms (Extended Mix) 07. spacemen - High On The Feeling (Club Mix) 08. LewRaz, Yasmin Jane - Ownin' The Night (Extended Mix) 09. Yung Bae, axxa - Arrival (Extended Mix) 10. LP Giobbi - Carolyn (Original Mix) 11. Kira Divine feat. Marques Toliver & PNAU - Archaeology 12. JOEZI feat. Cali Bee - Give Me Tonight (Extended Mix) 13. Jersey - Ghost Of What Could Be (Original Mix) 14. Rommii - All Night On My Own (Extended)

For more information on John Antal and his work:+ https://madsciblog.tradoc.army.mil/497-the-dictators-dream-a-conversation-with-col-john-antal-usa-ret/+ https://www.youtube.com/watch?v=yoktqS7aWgo+ https://www.youtube.com/watch?v=rSKRH_UqSko Hosted on Acast. See acast.com/privacy for more information.

TOM HANKSGIVING: Andrew bought a new Mac, so he decides to play No Man's Sky while D. Bethel is Tom Hanksful for the delightful retro-stylings of the indie RPG, Beyond Galaxyland. GRIPESGIVING: With all the thanks out of the way, our hosts decide to complete the holiday by complaining about things. Andrew is mad at the new season of Cobra Kai while D. Bethel becomes irrationally furious with the new Wicked movie. TOPICS: (00:00) Intro: It's American Thanksgiving (03:34) Andrew buys a Mac Mini and plays No Man's Sky (17:59) D. Bethel loves Beyond Galaxyland (25:19) Outro: Gripesgiving #1 - Cobra Kai season 6 is interminable (28:27) Gripesgiving #2 - the 3-hour Wicked adaptation is only PART ONE?! (32:13) Outtakes RELEVANT EPISODES: "Chekhov's Honk" (22 January 2021): Where our hosts discuss The Karate Kid, The Karate Kid Part 2, and The Karate Kid Part 3, briefly. "Too Many Johnnies" (5 February 2021): Where our hosts dive into Cobra Kai. "Nomanski" (24 November 2023): Where our hosts talk about No Man's Sky. INFO: Subscribe to our YouTube channel. Visit our website at forallintents.net and leave your thoughts as comments on the page for this episode. Join our Facebook page Social: Andrew - Mastodon, D. Bethel - Instagram FEATURED MUSIC: "Disco Medusae" by Kevin McLeod Link: https://incompetech.filmmusic.io/song/3652-disco-medusae "District Four" by Kevin McLeod Link: https://incompetech.filmmusic.io/song/3662-district-four Tracks are licensed under Creative Commons BY Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/

The crew finds safety to figure out how to survive Night City. https://linktr.ee/clashofkrits   Support us on https://patreon.com/ClashofKrits to get access to our after show "Late Night Traffic" and More!

Urbana Radio Show By David Penn Chapter #659 01. Cantos - Pocket Lint 02. Ferreck Dawn x New Machine x Maverick Sabre - For The Weekend - Defected 03. Paul Adam - Desire - Jackies Music 04. Urban Soul Feat. Roland Clark - Alright (Mellow Man's Deeper Soul Mix) 05. J Paul Getto - The Vibe 06. Fedde Le Grand x Todd Terry Feat. Rowetta - Baby Can You Reach - Armada Music 07. David Penn & Rober Gaez - Deep Inside (Jay Vegas Remix) - Urbana Recordings 08. Riordan - As The Beat Goes Onnn 09. Milk & Sugar, James Hurr - I Love Music - Toolroom 10. Yero Feat. 9 - After Hours - Kryteria Records 11. KPD - Living My Dream - Total Freedom 12. Calvin Harris & Rag'n'Bone Man - Giant (Riva Starr Tribe Vibe Remix) Thanks to all the labels and artist for their music. All tracks selected and mixed by David Penn DJDAVIDPENN.COM FACEBOOK DJDAVIDPENN INSTAGRAM @DJDAVIDPENN INGENIUM BOKINGS EUROPA MUSIC MANAGEMENT Encoded by MUSICZONE PODCAST SERVICES.

The Martin Garrix Show #523Mix 11. Ferreck Dawn x New Machine x Maverick Sabre - For The Weekend [DEFECTED]2. ELYX - Free Your Mind [ACTUATION]3. Alterboy - What About Me [EXPERTS ONLY]4. Danny Rhys - Switch [TOOLROOM]5. Beyond Chicago - Need You feat. Janai [SOLOTOKO]6. Mason Flint - Power feat. Jasmine Knight [CLUB SWEAT]7. Martin Ikin - Everybody's Got To Learn Sometime [ULTRA]8. Ian Asher x Joe Stone - Never Leave You [MUSICAL FREEDOM]9. Vintage Culture - Pleasure Chasers (Joris Voorn Remix) [VINTAGE CULTURE]Mix 210. Meduza x Hayla - Another World [UMG]11. Tiësto, Swimming Paul - VHS RAVE [MUSICAL FREEDOM]12. Rain Radio, Cat Dealers - Eyes [SOUNDON]13. KLIPTO & GRX - Express Yourself [STMPD RCRDS]14. Tujamo x Toby Romeo x Lady Leshurr - Day In Day Out [CITY STARS RECORDS]15. Julian Jordan & Nouni - Never Stoppin' [STMPD RCRDS]16. Martin Garrix & Dyro - Latency [STMPD/SONY]17. Martin Garrix feat. Mike Yung - Dreamer (Nicky Romero Remix) [STMPD/SONY]A weekly selection of tracks that I love to listen to at home or play out at a party. New episodes uploaded weekly.

01. Husky & Sydney Jo Jackson - Get Down (Birdee Extended Remix) 02. Kisch - Dive Deep (Extended Mix) 03. Ferreck Dawn x New Machine x Maverick Sabre - For The Weekend (Extended Mix) 04. Kevin McKay, NYLA - 2 On (Kevin McKay & Ludo Lacoste Extended VIP) 05. Milk & Sugar, James Hurr - I Love Music (Extended Mix) 06. Mercer - In My Arms (Extended Mix) 07. Swedish House Mafia feat Alicia Keys - Finally (Extended Mix) 08. Steff Da Campo & Robbie Mendez - People (Extended Mix) 09. Mr. Belt & Wezol, Shift K3Y - Promises (Extended Mix) 10. Soul Heads - I'll Be Here (Extended Mix) 11. Cherry Tooth - Wanna Get High (Extended Mix) 12. Illyus & Barrientos - D.A.N.C.E (Extended Mix) 13. SHEE - Close My Eyes (Extended Mix) 14. Noise Cans - On Your Face (Extended Mix)

Urbana Radio Show By David Penn Chapter #656 1. David Penn - The Heat (James Mac Remix) - Club Sweat 2. Ferreck Dawn, New Machine, Maverick Sabre - For The Weekend - Defected 3. Junior Sanchez, Mike Dean - Weekend Vibes feat. Lee Wilson - D4 D4nce 4. Moon Boots - Hypnotizin' - Jackies Music 5. Soulsearcher - Can't Get Enough (Prunk Remix) - Defected 6. Alan Dixon - Nothing But Happiness - Glitterbox 7. Definite Grooves - Shake You Loose 8. Waze x Life On Planets - Bang 9. KPD - Money & Fame - Freakin909 10. Wh0 & Cassimm - Samba - Golden Recordings 11. Marco Lys & Ango Tamarin - Really In Love - Sbjkt 12. Robbie Rivera, Rivaz, Gambafreaks - Magalenha - D:Vision 13. Milk & Sugar, James Hurr - I Love Music - Toolroom Thanks to all the labels and artist for their music. All tracks selected and mixed by David Penn DJDAVIDPENN.COM FACEBOOK DJDAVIDPENN INSTAGRAM @DJDAVIDPENN INGENIUM BOKINGS EUROPA MUSIC MANAGEMENT Encoded by MUSICZONE PODCAST SERVICES.

Thank you to our Poly Podcast sponsor WL Plastics.

01. KC Lights - Turn Around 02. Gamuel Sori x Izzy Bizu - Messing With My Heart 03. Ferreck Dawn x New Machine x Maverick Sabre - For The Weekend 04. Hayden James - All In 05. Morgan Page, MorganJ & CloudNone - Water 06. Öwnboss x Dino Warriors - Can You Dig It 07. James Hype ft. Shamiya Battles - 7 Seconds 08. Max Styler & Oscar L - Addiction 09. Tita Lau & Chocolate Puma - I Wanna Be U 10. Crusy - Hey Girls, B-Boys 11. Tiësto - Drifting (KREAM Remix) 12. Riordan - As The Beat Goes Onnn 13. IDRIS & Shermanology - Shake Body 14. MOGUAI x Pizzata&Klein x Salvatore Mancuso - Free Your Mind 15. deadmau5 - Strobe (Layton Giordani Remix) 16. Benny Benassi ft. The Biz - Satisfaction (Zamna Soundsystem & Andro Remix) 17. Jax Jones x Joel Corry x Jason Derulo - Tonight (D.I.Y.A) [VIP Mix] 18. Mr. Belt & Wezol x Shift K3Y - Promises 19. Swedish House Mafia feat. Alicia Keys - Finally 20. Nathan Dawe x Joel Corry x SACHA - Higher

1. Ferreck Dawn x New Machine x Maverick Sabre - For The Weekend 2. Morgan Page, MorganJ & CloudNone - Water 3. Chico Rose - Chan Chan 4. Inner City x Anton Powers - Pennies From Heaven 5. (SR) Tita Lau, Chocolate Puma - I Wanna Be U 6. Croatia Squad - Get On The Floor 7. Tiësto, Swimming Paul - VHS RAVE 8. Lucas & Steve - Renegade Master 9. (AOW) Sander van Doorn - Take Yo' Praise 10. Tiësto, Lucas & Steve, SĀN-Z - ZENLESS 11. Mr. Belt & Wezol, Shift K3Y - Promises 12. Bingo Players, Disco Fries, Fatman Scoop - Our House 13. MOGUAI x Pizzata&Klein x Salvatore Mancuso - Free Your Mind 14. Lucas & Steve - Are You Ready 15. ROBBIE MENDEZ - HOME 16. Jonasu - Healing 17. HEDEGAARD, Martin Jensen, Victoria Nadine - Favorite Mistakes (HEDEGAARD VIP Mix) 18. Bassjackers, Yves V - Alibi

1. Ferreck Dawn x New Machine x Maverick Sabre - For The Weekend 2. Morgan Page, MorganJ & CloudNone - Water 3. Chico Rose - Chan Chan 4. Inner City x Anton Powers - Pennies From Heaven 5. (SR) Tita Lau, Chocolate Puma - I Wanna Be U 6. Croatia Squad - Get On The Floor 7. Tiësto, Swimming Paul - VHS RAVE 8. Lucas & Steve - Renegade Master 9. (AOW) Sander van Doorn - Take Yo' Praise 10. Tiësto, Lucas & Steve, SĀN-Z - ZENLESS 11. Mr. Belt & Wezol, Shift K3Y - Promises 12. Bingo Players, Disco Fries, Fatman Scoop - Our House 13. MOGUAI x Pizzata&Klein x Salvatore Mancuso - Free Your Mind 14. Lucas & Steve - Are You Ready 15. ROBBIE MENDEZ - HOME 16. Jonasu - Healing 17. HEDEGAARD, Martin Jensen, Victoria Nadine - Favorite Mistakes (HEDEGAARD VIP Mix) 18. Bassjackers, Yves V - Alibi

SPONSOR: www.mycomputerexorcist.com SPONSOR: www.mycomputerexorcist.com PRE-ORDER HERE: https://tentontradingco.com/collections/burn-my-eyes-30th-anniversary-us In the August 8th edition of CAP News, Chris dives into the highly anticipated release of *Diamonds in the Rough*. Set to drop on September 4th, 2024, this album is already generating buzz in the rock community. Chris breaks down the tracks, giving you an in-depth look at what to expect from this upcoming release. If you're a fan of rock music, you won't want to miss this review. Chris offers his honest take on the album's sound, lyrics, and overall impact. Tune in to find out if *Diamonds in the Rough* lives up to the hype. #CAPNews #DiamondsInTheRough #ChrisAkin #AlbumReview #RockMusic #NewRelease #September2024 #MusicReview #RockAlbum #UpcomingAlbums #MusicBuzz #AlbumBreakdown NOTE: Everything said here, and on every episode of all of our shows are 100% the opinions of the hosts. Nothing is stated as fact. Do your own research to see if their opinions are true or not. Please SUBSCRIBE, click the notification bell, leave a comment or a like, and share this episode!

Join the guys as they chat with Tay Whiteside and Walker Hooper of Lift Arc Studios. Tay, renowned for his expertise in salvage and fabrication, gained fame on the DIY Network's Salvage Dawgs, working with his father, Mike Whiteside, co-owner of Black Dog Salvage. At Lift Arc Studios, Tay showcases his artistic talent, creating remarkable metal sculptures and designs.   Also in this episode, ShopSabre announces the release of their new TC (Tube Cutter) machine, and they discuss the upcoming IWF 2024 event in August.   Weekly featured segments include "Internet is Broken," "Customer Questions," "Motivational Quote of the Week," and "Question for the Audience." Question for the Audience:If Money, space, or time was not a constraint to your decision for one thing - What would you do right now for your business or life & why?  Learn More and Follow Us: https://www.instagram.com/shopsabre https://www.facebook.com/shopsabre

Mon, 01 Apr 2024 20:30:00 GMT http://relay.fm/upgrade/506 http://relay.fm/upgrade/506 Legacy When? Legacy Now? 506 Jason Snell and Myke Hurley We often cite anonymous reports about Apple's future, but where do those reports come from? We discuss of the value and ethics of Apple rumor coverage. Also, we've seen the latest Vision Pro immersive video and have strong opinions. We often cite anonymous reports about Apple's future, but where do those reports come from? We discuss of the value and ethics of Apple rumor coverage. Also, we've seen the latest Vision Pro immersive video and have strong opinions. clean 6050 Subtitle: Let's Go Snell!We often cite anonymous reports about Apple's future, but where do those reports come from? We discuss of the value and ethics of Apple rumor coverage. Also, we've seen the latest Vision Pro immersive video and have strong opinions. This episode of Upgrade is sponsored by: Sanebox: Clean up your inbox in minutes. Sign up for a two-week free trial and a $25 credit. Ooni Pizza Ovens: Bring restaurant quality pizza to your home. Discount automatically applied at checkout. ExpressVPN: High-Speed, Secure & Anonymous VPN Service. Get an extra three months free. Links and Show Notes: Get Upgrade+. More content, no ads. Check out Upgrade merch! Submit Feedback The Amazing Spider-Man (2018 - 2022) | Comic Series | Marvel All of the Marvels: A Journey to the Ends of the Biggest Story Ever Told – Wolk, Douglas: Amazon Here's What Apple Retail's New Machine to Update iPhones in the Box Looks Like - MacRumors WWDC24 - Apple Developer Apple Developer - YouTube What Will the European Commission Do With the Money It Receives From DMA Related Fines? – Perplexity When Is the New iPad Pro, iPad Air Coming Out? Apple Plans Early May Launch - Bloomberg Apple Sues Former Employee for Leaking iPhone's Journal App and More - MacRumors Michael Gartenberg's question on Leaks MacWEEK - Wikipedia MacRumors Buyer's Guide Apple's Immersive Video problem – Six Colors MLS on Vision Pro, The Vision Pro's Missing Content, The Vision Pro's DRI – Stratechery by Ben Thompson PSA: The MLB app doesn't work on the Mac anymore – Six Colors MLB for visionOS strikes out on Opening Day – Six Colors The Talk Show ✪: Ep. 397, With Jason Snell

Mon, 01 Apr 2024 20:30:00 GMT http://relay.fm/upgrade/506 http://relay.fm/upgrade/506 Jason Snell and Myke Hurley We often cite anonymous reports about Apple's future, but where do those reports come from? We discuss of the value and ethics of Apple rumor coverage. Also, we've seen the latest Vision Pro immersive video and have strong opinions. We often cite anonymous reports about Apple's future, but where do those reports come from? We discuss of the value and ethics of Apple rumor coverage. Also, we've seen the latest Vision Pro immersive video and have strong opinions. clean 6050 Subtitle: Let's Go Snell!We often cite anonymous reports about Apple's future, but where do those reports come from? We discuss of the value and ethics of Apple rumor coverage. Also, we've seen the latest Vision Pro immersive video and have strong opinions. This episode of Upgrade is sponsored by: Sanebox: Clean up your inbox in minutes. Sign up for a two-week free trial and a $25 credit. Ooni Pizza Ovens: Bring restaurant quality pizza to your home. Discount automatically applied at checkout. ExpressVPN: High-Speed, Secure & Anonymous VPN Service. Get an extra three months free. Links and Show Notes: Get Upgrade+. More content, no ads. Check out Upgrade merch! Submit Feedback The Amazing Spider-Man (2018 - 2022) | Comic Series | Marvel All of the Marvels: A Journey to the Ends of the Biggest Story Ever Told – Wolk, Douglas: Amazon Here's What Apple Retail's New Machine to Update iPhones in the Box Looks Like - MacRumors WWDC24 - Apple Developer Apple Developer - YouTube What Will the European Commission Do With the Money It Receives From DMA Related Fines? – Perplexity When Is the New iPad Pro, iPad Air Coming Out? Apple Plans Early May Launch - Bloomberg Apple Sues Former Employee for Leaking iPhone's Journal App and More - MacRumors Michael Gartenberg's question on Leaks MacWEEK - Wikipedia MacRumors Buyer's Guide Apple's Immersive Video problem – Six Colors MLS on Vision Pro, The Vision Pro's Missing Content, The Vision Pro's DRI – Stratechery by Ben Thompson PSA: The MLB app doesn't work on the Mac anymore – Six Colors MLB for visionOS strikes out on Opening Day – Six Colors The Talk Show ✪: Ep. 397, With Jason Snell

Drs. Shaalan Beg and Travis Osterman discuss a machine learning model, recently featured in JCO Clinical Cancer Informatics, that uses electronic health record data to accurately predict the effectiveness and toxicity of treatment with immune checkpoint inhibitors. The new AI model can be used to provide a personalized risk-benefit profile, inform therapeutic decision-making, and improve clinical trial cohort selection.   TRANSCRIPT Dr. Shaalan Beg: Hello, and welcome to the ASCO Daily News Podcast. I'm Dr. Shaalan Beg, your guest host for today. I am an adjunct associate professor at UT Southwestern's Simmons Comprehensive Cancer Center.  Cancer immunotherapy has transformed the treatment landscape by providing new and effective treatment options for many solid and hematologic malignancies. But while many patients experience a remarkable response to immune checkpoint inhibitors, other patients can suffer life-threatening immune checkpoint toxicities. Today, we will be discussing a machine learning solution that can assess a patient's immune checkpoint inhibitor risk-benefit profile based primarily on routinely collected structured electronic health record data. This novel AI solution was recently featured in JCO Clinical Cancer Informatics, and I am delighted to welcome one of the report's authors, Dr. Travis Osterman. He is an associate vice president for research informatics and associate professor in the Department of Biomedical Informatics and the Division of Hematology Oncology at Vanderbilt University Medical Center in Nashville, Tennessee. Dr. Osterman also serves as the director of cancer clinical informatics at the Vanderbilt Ingram Cancer Center.  Our full disclosures are available in the transcript of this episode, and disclosures related to all episodes of the podcast are available at asco.org/DNpod.  Dr. Osterman, it's great to have you on the podcast today.   Dr. Travis Osterman: Thanks, Shaalan. It's great to be here. Thank you for the invitation.   Dr. Shaalan Beg: Congratulations on your recently published article in the JCO CCI titled "Prediction of Effectiveness and Toxicities of Immune Checkpoint Inhibitors Using Real World Patient Data." Why did you decide to address this specific problem?   Dr. Travis Osterman: I am a practicing medical oncologist at Vanderbilt, I specialize in thoracic malignancies. Immunotherapy has been a significant part of my practice from the beginning. And I think for all of us, we have patients in our practices that are tremendous responders. I have stories of my patients, a few of which, at least, are able to get years of benefit even after stopping therapy, and potentially some even stage 4 patients that are amazingly seemingly cured after their treatments. But I also have patients that experience severe toxicities, some of those are life-threatening or life ending, but many of those carry morbidity. In my population, I see a lot of pneumonitis, and that really alters patients' quality of life. And the biggest conversation I have with patients is: “How do I know which of these outcomes I'm going to have, if I'm going to get benefits from these therapies or am I going to get one of these side effects or toxicities?” And we set out to try to answer that question with data.   Dr. Shaalan Beg: When electronic medical records started to make their way into the clinic, I remember all of us thinking about the wonderful applications where we could use the data to help guide the clinical care, assign the right treatment for the right patient at the right time, and learn from other patients' experiences to improve the care of the person who's in front of us. And my personal opinion is that we haven't realized our electronic medical records' potential to that extent. And efforts like the one you published in JCO CCI is the culmination of one of the efforts, and I can only imagine how much time and effort it must have taken to develop that and we're hoping is the first of many more to come. For our listeners, can you talk us through the steps required to develop such a tool, and why now is the right time, and why we're starting to see these evolve?   Dr. Travis Osterman: This project would not have been possible 20 years ago. It relies on having what we would call structured data available for our patients that are receiving cancer care, so that's vital signs, laboratory values, and diagnoses, all of the things that we routinely collect in the electronic health record. So that is step 1. This project required that those systems be not just in place at academic centers but be widely available because our goal is to set up systems that will be able to transform cancer care, not just at academic institutions, but for the entire practice of oncology.  The second piece is you need enough data to be able to train these models. And so, we needed to be practicing with checkpoint inhibitors long enough to see patients that had toxicities, to see patients that had benefit, and then to jump into the data science of actually trying to learn from them. And so this really was the culmination of systems put in place by a lot of people before us and then really the right time [when] we started to have now enough data to really start to learn from.   Dr. Shaalan Beg: The publication discusses the steps of how you validated your tool. Talk me through how you see this being applied to the point of care for the next time you are about to start an immune checkpoint inhibitor for your lung cancer patient?   Dr. Travis Osterman: I think there are two different primary lanes that these types of models can be applied. In the drug development space, I think many of us are familiar that many assets, many drugs that are in the development pipeline are halted because of adverse events in toxicity profiles, but we also realize that not everyone gets those toxicities. And so we envision a future where before a drug that's in the drug development pipeline is taken out of the development pipeline, potentially, you could screen patients that are at lowest risks of actually having side effects from that immunotherapy and only screen those patients into the trial and that would potentially make more drugs available to more patients going forward. So I think that that's 1 lane.  I think the other lane in clinical practice is, let's say that I'm treating a patient who we determine has an increased risk for colitis. Instead of only seeing that patient back in 3 weeks, potentially, now, what if I had one of our nurse navigators, call the patient at weekly check-ins between visits to check in and see whether or not they were having any episodes of diarrhea and trying to intervene earlier. That might allow us to keep patients both out of the hospital, out of the emergency department to treat their symptoms more quickly to decrease the severity of their toxicity and keep them on treatments, especially if they're receiving benefit from it. So, I think there's an opportunity to improve both drug development and making more drugs available to patients and then also to identify patients that are at risk for toxicity, and then to do interventions to help mitigate those risks. Really, the idea of precision risk mitigation.   Dr. Shaalan Beg: One of the problems with electronic medical record-based tools in the past has been that they don't evolve with time. We develop it, we set it, we deploy it, and it almost feels, to the users at least, that it stops evolving after that. With novel therapeutic agents coming into the clinic, we're seeing new ADCs, new novel checkpoint inhibitors entering the market. How do you envision tools such as yours to be refreshed so they can stay relevant with the modern armamentarium of medications which are being used?   Dr. Travis Osterman: So, if you ask any data scientist, the most requested item they will ask for is more data. And so, this initial set of models that we've described in this publication were trained exclusively on a single institution's data at Vanderbilt University Medical Center as we continue both to see more patients here, and then ideally look forward to collaborations with other centers. We expect that these models will continue to be refined and that the performance will improve as we increase the amount of training data, and we hope that that will do 2 things. One, it will counteract the kind of model drift that you described. But then two, it will allow us to ask some more specific questions that honestly, we weren't really powered to answer in our study here. For instance, we didn't look at cardiac toxicity, which is a concern if you're giving a CTLA-4 along with a PD-1 or PD-L1 inhibitor more so than single agent immunotherapy. We just don't have enough events to be able to train models on that. But with future collaborations, that would be a question we would love to tackle as well.  One of the things that's interesting about the implementation of these models is that we found many of the features that I would have expected to find as a practicing oncologist. For instance, when we're trying to predict the toxicity of pneumonitis inflammation of the lung, I as an oncologist would think that many of my patients that have COPD or interstitial lung disease at baseline seem to be at a higher risk. And so that's one of the features that I was looking to come out in the model. And that's exactly what we found. That was one of the contributing features that helps us predict a higher risk of pneumonitis. But what's interesting is that's certainly not the only feature; there end up being about a dozen features that are in that space that help predict that toxicity.   Similarly, for colitis, we found that the combination of receiving a CTLA-4 inhibitor in addition to a PD-1 or PD-L1 inhibitor, that combination together, which would increase risk for colitis, which is well-documented in our literature. So these models are not entirely black boxes. We've published the top features of these models that contribute to our predictions. And I think clinically the challenge for me has always been if I have a patient who has COPD, but it's pretty well-controlled and their O2 sat is normal, how does that patient's risk bring pneumonitis compared to someone who has poorly controlled COPD with low O2 sat at baseline, etc.? And so these models are really designed to help tease out some of those nuances.   Dr. Shaalan Beg: There are so many wonderful applications to use preexisting data that can improve the lives of our patients and frankly that can improve the work experience for clinicians. They can be used for risk stratification using these preexisting data. Can you talk a little bit about what are the barriers that people face or that your team faced in developing these tools, and what has changed or what's expected to change in the coming years to allow people to continue developing tools such as what was described?   Dr. Travis Osterman: I think it's important to realize that we are not unique in addressing this problem. This is a problem that I think has been a focal point of our cancer informatics community for the better part of the last, probably, decade. I think one of the things that distinguishes the work that we've done here is really this idea of clinical utility. And what I mean is we focused on data that would be collected at any routine oncology visit in the U.S., and I would argue worldwide, to use as features in our model. So, we're not running complex genetic testing that may or may not be paid for. We're not asking for new laboratory values to be sent or for extensive questionnaires that aren't already in clinical practice. We're using pieces that are already being connected into the pipeline of oncology practices, and I think that's one of the differentiators of this project versus many others in this space.  Right now, these are only EHR data. We have a part of our project that's looking at imaging data and whether that adds value. But one of the pieces that I always advocate for, if we're going to ask practices for instance to upload these imaging files or to send a CD to a central location to improve the outcome, that's harder to work into an oncologist workflow than if all the data are already there in the health record and you can click a button and calculate this person's risk profile. And so, we've really tried to be pragmatic about our approach as we've entered this realm and that's been a real focus of our team.   Dr. Shaalan Beg: Many of the listeners of today's podcast are busy clinicians, and you talked about how the idea for this project came from the problem you witnessed in your clinic. How can clinicians continue to be involved in such initiatives or drive these initiatives at their own institutions, in office situations where they may not have the resources that your team has? Can you speak to national efforts or collaborations in this regard?   Dr. Travis Osterman: Yeah. So, first of all, I would invite really anyone to reach out to our team, if they're in a position where they'll be interested in validating our models at their local institutions. We would be happy to work with them to provide the models to see how they perform on their data sets. I think that that's an important part of the academic review and informatics is to see how these models translate into other health care settings. And we also are interested to make sure that what I said in the prior discussion is correct, that we're only incorporating things that other institutions already have. So I think that that's certainly one.  The second is a part of a large National Cancer Data standard project called mCODE, the Minimal Common Oncology Data Elements, I chair that executive committee. And one of the pieces of that is trying to find a way to make all of these kinds of structured data interoperable between health records. And so I would just encourage all of my colleagues to always advocate for interoperability and, when there's an option, to store data in a way that makes that data more easily shared in the same formats between institutions. I think that that will pay many dividends for our field going forward. And I just want to plug all the team at mCODE for their work in this and maybe there'll be an integration and connection between mCODE and our project in the future.   Dr. Shaalan Beg: Thank you very much Dr. Osterman for sharing your insights with us today on the ASCO Daily News Podcast.   Dr. Travis Osterman: Thanks, Shaalan. Have a great day.   Dr. Shaalan Beg: And thank you to all our listeners for your time today. You'll find a link to Dr. Osterman's article in the transcript of this episode. And if you value the insights that you hear on the ASCO Daily News Podcast, please take a moment to rate, review, and subscribe wherever you get your podcast.   Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity or therapy should not be construed as an ASCO endorsement.   Find out more about today's speakers: Dr. Shaalan Beg @ShaalanBeg Dr. Travis Osterman @TravisOsterman   Follow ASCO on social media:  @ASCO on Twitter  ASCO on Facebook  ASCO on LinkedIn    Disclosures: Dr. Shaalan Beg: Employment: Science 37 Consulting or Advisory Role: Ipsen, Array BioPharma, AstraZeneca/MedImmune, Cancer Commons, Legend Biotech, Foundation Medicine Research Funding (Inst.): Bristol-Myers Squibb, AstraZeneca/MedImmune, Merck Serono, Five Prime Therapeutics, MedImmune, Genentech, Immunesensor, Tolero Pharmaceuticals   Dr. Travis Osterman: Stock and Other Ownership Interests: Faculty Coaching Honoraria: Amazon Web Services Consulting or Advisory Role: eHealth, AstraZeneca, Outcomes Insights, Biodesix, MD Outlook, GenomOncology, Cota Healthcare, Flagship Biosciences, Microsoft, Dedham Group, Oncollege Research Funding: GE Healthcare, Microsoft, IBM Watson Health Travel, Accommodations, Expenses: GE Healthcare, Amazon Web Services

Antidepressants changed my life. I have OCD and antidepressants did what nearly a decade of therapy, meditation, and supplements couldn't: they allowed me to live my life without being in a 24/7 spiral. (Bonus: they actually made therapy and meditation far more helpful once they started to work.) I think antidepressants are seriously misunderstood. Yes, they blunt negative emotions. But they also operate on personality and sense of self: they can make you bolder, less sensitive to failure, and less risk-averse. In short: they are a technology that changes how we see ourselves and the world. That's why I invited Dr. Peter D. Kramer on my show. Dr. Kramer is a psychiatrist and the author of eight books, including Listening to Prozac, which is an international bestseller. He has practiced psychiatry and taught psychotherapy at Brown University for nearly four decades. Listening To Prozac is one of my favorite books, and it documents Dr. Kramer's experiences as a psychiatrist seeing how antidepressants like Prozac changed his patients' sense of self and personality. Now, you might be wondering why have him on a show about ChatGPT? Well, technology can change who we are even if it comes as a software product rather than a pill. It's undoubtedly true that as generations of humans learn to live with AI, it will change what it means to be human—and how we see ourselves and the world. I think that can be a good thing, but it could also be scary. I wanted to talk to Dr. Kramer about his book, and see if we could apply some of his insights in Prozac to ChatGPT. It was an incredible conversation, and I was honored to talk to him. Want even more? Sign up for Every to unlock our ultimate guide to prompting ChatGPT. It's usually only for paying subscribers, but you can get it here for free. To hear more from Dan Shipper: Subscribe to Every: https://every.to/subscribe  Follow him on X: https://twitter.com/danshipper  To learn more about the topics in this episode: Listening to Prozac by Peter D. Kramer ChatGPT and the Future of the Human Mind by Dan Shipper SSRIs by Scott Alexander Timestamps: Introduction: 00:50 How technology changes the way we see ourselves and the world: 08:24 Antidepressants and their impact on our personality and sense of self: 21:25 How the availability of a technological solution prompts us to see the problem everywhere: 26:35 Technology alters the categories we have divided the world into: 34:06 How I use ChatGPT in my writing process: 40:05 Experimenting with ChatGPT to get relationship advice: 45:41 Prompting ChatGPT to be more specific: 51:16 Clearly indicate the tone you want ChatGPT to take: 55:11 Dr. Peter D. Kramer's final thoughts on ChatGPT as a therapist: 1:02:27 Links to resources mentioned in the episode: Dr. Peter D. Kramer: https://twitter.com/PeterDKramer  ChatGPT and the Future of the Human  Mind by Dan Shipper: https://every.to/chain-of-thought/chatgpt-and-the-future-of-the-human-mind  Listening to Prozac  by Dr. Kramer: https://www.amazon.com/Listening-Prozac-Landmark-Antidepressants-Remaking/dp/0140266712  Should You Leave? by Dr. Kramer: https://www.amazon.com/Should-You-Leave-Psychiatrist-Autonomy/dp/0140272798  Against Depression by Dr. Kramer: https://www.amazon.com/Against-Depression-Peter-D-Kramer/dp/0143036963  Ordinarily Well by Dr. Kramer: https://www.amazon.com/Ordinarily-Well-Antidepressants-Peter-Kramer/dp/0374536961  Pierre Menard, Author of the Quixote by Jorge Luis Borges: https://raley.english.ucsb.edu/wp-content/Engl10/Pierre-Menard.pdf  The Soul of A New Machine by Tracy Kidder: https://www.amazon.com/Soul-New-Machine-Tracy-Kidder/dp/0316491977  Making Hay by Verlyn Klinkenborg: https://www.amazon.com/Making-Hay-Verlyn-Klinkenborg/dp/0941130185  Oranges by John McPhee: https://www.amazon.com/Oranges-John-McPhee/dp/0374512973 

Transferring installed software to a new machine isn't as easy as we might like. I'll list the options.

Tracy Kidder is the author of eleven books, including The Soul of a New Machine and Mountains Beyond Mountains. His latest is Rough Sleepers. “I do think it's an interesting challenge to try to write about virtue, with all that's always mixed with it. Some writers have said it's virtually impossible … but it's not impossible. … People who are really trying, struggling against the odds, I think they're worth writing about.” Show notes: tracykidder.com Kidder on Longform Kidder's Atlantic archive 01:00 “‘You Have to Learn to Listen': How a Doctor Cares for Boston's Homeless” (The New York Times • Jan 2023) 06:00 “The Good Doctor” (New Yorker • July 2000) 06:00 Mountains Beyond Mountains (Random House • 2009) 19:00 Good Prose (Kidder and Richard Todd • Random House • 2013) 21:00 House (Houghton Mifflin • 1985) Learn more about your ad choices. Visit podcastchoices.com/adchoices

➤ Jimmy Soni, author of 'The Founders' joins Rob Maurer to discuss the early days of Elon Musk, the story of x.com and PayPal, where Twitter may be headed, and more. The Founders: https://amzn.to/3V7oGWZ The Soul of A New Machine: https://amzn.to/3jcqGzY Find Jimmy Soni on Twitter @jimmyasoni 0:00 Jimmy Soni & The Founders 0:41 Backstory on the book 4:38 Understanding Elon 10:22 Elon's early days and Twitter motivation 14:25 A vision unfulfilled 16:57 Being wrong 20:20 Organizational change 22:06 Speed 24:02 Elon forced out of PayPal 34:22 Elon's mindset and overcoming challenges 39:55 Elon's motivation & character 47:08 Engineering vs. the world 50:31 Filtering out the noise 53:08 Misconceptions Shareloft: https://www.shareloft.com Twitter: https://www.twitter.com/teslapodcast Patreon: https://www.patreon.com/tesladailypodcast Tesla Referral: https://ts.la/robert47283 Executive producer Jeremy Cooke Executive producer Troy Cherasaro Executive producer Andre/Maria Kent Executive producer Jessie Chimni Executive producer Michael Pastrone Executive producer Richard Del Maestro Executive producer John Beans Disclosure: Rob Maurer is long TSLA stock & derivatives. Product links may earn additional revenue for the channel.

Diagnosing and containing a disease outbreak, or the health effects of a disruptive event like a natural disaster, can be a huge task. A study out Friday from New York University suggests that a new machine learning model could improve health officials’ ability to respond to future pandemics and other public health crises. The research was done in partnership with Carnegie Mellon University and New York City's Department of Health and Mental Hygiene. Marketplace’s Kimberly Adams speaks with Daniel Neill, a computer science professor at NYU and the director of its Machine Learning for Good Laboratory, which released the study. He explains how this machine learning model works.

Diagnosing and containing a disease outbreak, or the health effects of a disruptive event like a natural disaster, can be a huge task. A study out Friday from New York University suggests that a new machine learning model could improve health officials’ ability to respond to future pandemics and other public health crises. The research was done in partnership with Carnegie Mellon University and New York City's Department of Health and Mental Hygiene. Marketplace’s Kimberly Adams speaks with Daniel Neill, a computer science professor at NYU and the director of its Machine Learning for Good Laboratory, which released the study. He explains how this machine learning model works.